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Down syndrome births by rurality and type of antenatal care. For rural areas, trends were stable over the entire period 1990-2004. In contrast, the annual change in rates of Down syndrome births in urban areas differed significantly between 1990-1999 and 2000-2004 (−0.8% versus −14.3%, respectively) (Box 2).. For mothers receiving antenatal care from a private obstetrician, there was a non-significant fall of 2.9% per year in Down syndrome births between 1990 and 1999, but a significant fall of 27.5% per year from 2000 to 2004. In contrast, for women receiving shared care or public hospital care, the annual change in rates of Down syndrome births over the two time periods was similar and the differences were not significant: −1.9% (1990-1999) versus −2.4% (2000-2004) for shared care and +1.0% (1990-1999) versus +2.9% (2000-2004) for public hospital care (Box 2).. Cross-sectional analyses showed that before 2000 there were small non-significant differences in the birth rates for Down ...
Looking for online definition of megacystis-microcolon-intestinal hypoperistalsis syndrome in the Medical Dictionary? megacystis-microcolon-intestinal hypoperistalsis syndrome explanation free. What is megacystis-microcolon-intestinal hypoperistalsis syndrome? Meaning of megacystis-microcolon-intestinal hypoperistalsis syndrome medical term. What does megacystis-microcolon-intestinal hypoperistalsis syndrome mean?
Continuous renal replacement therapy, Peritoneal dialysis, Kidney transplant, Kidney biopsy, Dialysis, Hemodialysis, Ho...rseshoe kidney, Membranous nephropathy, Medullary sponge kidney, Kidney infection, Protein in urine, Acute kidney injury , Minimal change disease, Kidney stone, Blood in urine, Multicystic kidney dysplasia, UTI, High blood pressure in children, Chronic kidney disease, Glomerular disease, Renal tubular acidosis, End-stage renal disease, Polycystic kidney disease, Congenital kidney disorder, Kidney cyst, Postural proteinuria, Membranoproliferative glomerulonephritis, Renovascular disease, Hemolytic uremic syndrome, Nephrotic syndrome, Renal artery stenosis, Hydronephrosis, Single kidney, Focal segmental glomerulosclerosis, Inherited cystic kidney disorder, Childhood nephrotic syndrome, IgA nephropathy. ...
Background: The prevalence of metabolic syndrome (MS) after renal transplantation has yet to be elucidated. In the present study, we investigated the prevalence of MS in Japanese renal transplant recipients.. Methods: A cross-sectional study was conducted to determine the prevalence of MS in 101 renal transplant recipients at Osaka City University Hospital. The prevalence of MS was determined using the National Cholesterol Education Program-Adult Treatment Panel III (NCEP-ATPIII) criteria (modified and original) and the International Diabetes Federation (IDF) criteria.. Results: Using the modified (Japanese) NCEP criteria, a total of 24 out of 101 patients (23.8%) had MS including 21 out of 64 male patients (32.8%) and three out of 37 female patients (8.1%). Using the modified (Asian) NCEP criteria, MS was diagnosed in 23 patients (22.8%); 19 male (29.7%) and four female (10.8%). Using the original NCEP criteria, MS was diagnosed in 15 patients (14.9%); 12 male (18.8%) and three female (8.1%). ...
Sister chromatid exchange (SCE) analysis is the most sensitive method for assessing chromosome damage induced by chemical mutagens. We report the SCE of peripheral blood lymphocytes in children with primary nephrotic syndrome (NS) treated with chlorambucil. Group I consisted of 20 normal children, group 2 of 14 children with primary NS who had never received a cytotoxic drug and group III of 7 children with primary NS who had received chlorambucil, which was discontinued 6-36 months prior to the study. Group IV consisted of 4 nephrotic children who were receiving chlorambucil therapy during the study. There was no significant increase in SCE in group III compared with group I or group II (P≫0.05). A significant rise in SCE (P|0.05) was seen in all patients in group IV.
Our group of primary SS patients showed a 19% prevalence of anti-HCV antibodies by third generation ELISA while only 10% of the patients had HCV viraemia. Several studies have considered this question and detected prevalences ranging from 0-75%.4 5Discrepancies among the studies could be caused by: (1) different clinical criteria for the diagnosis of SS, (2) analysis of anti-HCV antibodies in serum, which can lead to false positive results because of hyperglobulinaemia or gammaglobulin treatment as noted by others4 and, (3) differences in the incidence of HCV among different populations.. It is of interest to note the presence of HCV infection exclusively in primary SS patients. This result could be attributed (1) to a pathogenic role of HCV in primary SS, as has been previously suggested with other viral agents,2 or (2) to the presence of a sicca syndrome similar to primary SS leading to the misclassification of asymptomatic HCV infected patients as primary SS.5 Morphological examination of the ...
Services provided by us. Worcester Hospital has a dedicated paediatric Down syndrome clinic open to all citizens with children who have Down syndrome. The clinic takes place every 3 months on a Friday morning and all children with Down syndrome are welcome to make use of the services available at the clinic.. Tygerberg Hospital offers a weekly Down syndrome support group, which is run by the Down Syndrome Association. It offers early developmental stimulation and support to parents.. At Red Cross War Memorial Children's Hospital, very specific services are offered for children who have Down syndrome and their families. The Toy Library, which is situated near the Developmental Clinic, attends to children with Down syndrome as well as their caregivers, from birth until they start school. Appointments are made monthly in accordance with the children's age so that the families of same-aged children meet with each other once a month when attending the Toy Library. This encourages the development of ...
TY - JOUR. T1 - Prenatal diagnosis of a transient myeloproliferative disorder in trisomy 21. AU - Baschat, A. A.. AU - Wagner, T.. AU - Malisius, R.. AU - Gembruch, U.. PY - 1998/7/1. Y1 - 1998/7/1. N2 - We report the prenatal diagnosis of a transient myeloproliferative disorder suggestive of leukaemia in a fetus with hepatosplenomegaly, hydrops and 47,XY,+21 karyotype. The initial fetal white blood cell count at 26 + 5 weeks' gestation was 190/nl with 70 per cent blast cells. Immunophenotyping of the large blasts revealed surface markers suggestive of an early stem cell differentiation arrest resulting in undifferentiated polyclonal myelopoiesis. The fetal heart tracing showed minimal beat-to-beat variability in the presence of high leukocyte counts. Serial fetal blood sampling showed decreasing blast cells in the peripheral blood and normalization of white blood cell counts. Although there was increasing hydrops, this period was marked by improvement of the fetal heart rate pattern. Finally ...
salivary gland biopsy: Find the most comprehensive real-world treatment information on salivary gland biopsy at PatientsLikeMe. 0 patients with fibromyalgia, multiple sclerosis, major depressive disorder, generalized anxiety disorder, diabetes type 2, post-traumatic stress disorder, systemic lupus erythematosus, bipolar disorder, Parkinson's disease, panic disorder, rheumatoid arthritis, high blood pressure (hypertension), myalgic encephalomyelitis/chronic fatigue syndrome, persistent depressive disorder (dysthymia), amyotrophic lateral sclerosis, epilepsy, migraine, hypothyroidism, osteoarthritis, traumatic brain injury, bipolar II disorder, attention deficit/hyperactivity disorder, asthma, social anxiety disorder, high cholesterol (hypercholesterolemia), irritable bowel syndrome, idiopathic pulmonary fibrosis, gastroesophageal reflux disease, bipolar I disorder or psoriasis currently have salivary gland biopsy.
TY - JOUR. T1 - Exchange transfusion and cytarabine for transient abnormal myelopoiesis in hydrops fetalis. AU - Okamura, Tomoka. AU - Washio, Yousuke. AU - Yoshimoto, Junko. AU - Tani, Kazumasa. AU - Tsukahara, Hirokazu. AU - Shimada, Akira. PY - 2019. Y1 - 2019. N2 - Most cases of transient abnormal myelopoiesis (TAM) in neonates with Down syndrome (DS) resolve spontaneously; however, DS-TAM neonates with hydrops fetalis (HF) show poor clinical outcomes. We report three infants with DS-TAM and HF who were treated with exchange transfusion (ET) followed by low-dose cytarabine (LD-CA). All of them survived without developing liver failure, acute leukemia, or other serious adverse events. Our results suggest that this combination treatment with ET and LD-CA would be safe, tolerable and effective as an novel approach for DS-TAM patients with HF.. AB - Most cases of transient abnormal myelopoiesis (TAM) in neonates with Down syndrome (DS) resolve spontaneously; however, DS-TAM neonates with hydrops ...
TY - JOUR. T1 - Orthostatic Intolerance and Postural Orthostatic Tachycardia Syndrome in Joint Hypermobility Syndrome/Ehlers-Danlos Syndrome, Hypermobility Type. T2 - Neurovegetative Dysregulation or Autonomic Failure?. AU - Celletti, Claudia. AU - Camerota, Filippo. AU - Castori, Marco. AU - Censi, Federica. AU - Gioffrè, Laura. AU - Calcagnini, Giovanni. AU - Strano, Stefano. PY - 2017. Y1 - 2017. N2 - Background . Joint hypermobility syndrome/Ehlers-Danlos syndrome, hypermobility type (JHS/EDS-HT), is a hereditary connective tissue disorder mainly characterized by generalized joint hypermobility, skin texture abnormalities, and visceral and vascular dysfunctions, also comprising symptoms of autonomic dysfunction. This study aims to further evaluate cardiovascular autonomic involvement in JHS/EDS-HT by a battery of functional tests.Methods. The response to cardiovascular reflex tests comprising deep breathing, Valsalva maneuver, 30/15 ratio, handgrip test, and head-up tilt test was studied in ...
What are the aims of this leaflet?. This leaflet has been written to help you understand more about blue rubber bleb naevus syndrome. It tells you what this condition is, what it is caused by, what can be done about it, and where you can find out more about it.. What is blue rubber bleb naevus syndrome?. Blue rubber bleb naevus syndrome has also been called 'Bean syndrome' after Dr William Bean, who described it. It is caused by the congenital development of multiple venous malformations in the skin, soft tissues and gastrointestinal tract (intestine).. A 'syndrome' is a group of signs and symptoms that occur together. 'Naevus' is Latin for 'birthmark'. The 'blue rubber blebs' are small areas of blue mis-shaped veins with a rubber-like feel.. In some people, blebs are only seen in the skin. They can also occur in any other part of the body, most commonly the intestine.. What causes blue rubber bleb naevus syndrome?. The cause of blue rubber bleb naevus syndrome is not known. During the ...
A prospective study was undertaken in all children under the age of 12 years presenting for the first time with nephrotic syndrome, in order to determine the causes of nephrotic syndrome and to establish clinico-pathological correlations. Data on 27 patients who were admitted between December 1984 and June 1987 are presented. The investigations included haemoglobin levels, haemoglobin electrophoresis, antistreptolysin O titre, antinuclear factor, C3, VDRL, hepatitis-B-surface-antigen, serum albumin, urea and creatinine levels, urine microscopy, qualitative and quantitative urine protein assay, skin and throat swabs, and renal biopsy in 26/27 patients with features atypical of minimal change nephrotic syndrome. The commonest cause of nephrotic syndrome was mesangial proliferative glomerulonephritis in 30 percent of patients; 26 percent had minimal change nephrotic syndrome. In 59 percent, nephrotic syndrome was thought to be secondary to infection or sickle haemoglobinopathy. Post-streptococcal ...
TY - JOUR. T1 - Posterior reversible encephalopathy syndrome. T2 - The endothelial hypotheses. AU - Marra, A.. AU - Vargas, M.. AU - Striano, P.. AU - Del Guercio, L.. AU - Buonanno, P.. AU - Servillo, G.. PY - 2014. Y1 - 2014. N2 - Posterior reversible encephalopathy syndrome (PRES) is characterised by headache, visual disorders, seizures, altered mentation, consciousness disturbances and focal neurological signs. Initially described in patients with pre and eclampsia, severe hypertension, posterior reversible encephalopathy syndrome can occur in other clinical conditions such as infection, sepsis, shock, cancer chemotherapy, autoimmune diseases and hypercalcemia. Pathogenesis of brain lesions in PRES is not full understood and two opposite theories have been proposed. Both models are based on the central role of hypertension. According to the first theory, hypertension could cause a breakdown of the autoregulatory system in cerebral circulation, leading to brain edema. The second theory ...
Posterior reversible encephalopathy syndrome is a clinico-neuroradiological entity characterized by headache, vomiting, altered mental status, blurred vision and seizures with neuroimaging studies demonstrating white-gray matter edema involving predominantly the posterior region of the brain. We report a 47-year-old Caucasian man with liver cirrhosis who developed posterior reversible encephalopathy syndrome following an upper gastrointestinal hemorrhage and who was managed with induced hypothermia for control of intracranial hypertension and continuous veno-venous hemodiafiltration for severe hyperammonemia. We believe this is the first documented case report of posterior reversible encephalopathy syndrome associated with cirrhosis as well as the first report of the use of induced hypothermia and continuous veno-venous hemodiafiltration in this setting.
Epicardial fat is true visceral fat deposited around sub epicardial coronary vessels; it has been implicated in the development of coronary atherosclerosis. Epicardial fat has been also associated with insulin resistance. Tran's thoracic echocardiography provides a reliable measurement of epicardial fat thickness. Objective: To evaluate the association between epicardial fat thickness with metabolic syndrome and anthropometric parameters of adiposity. Methods: We assessed 70 patients who underwent echocardiography; the epicardial fat thickness on the free wall of the right ventricle was measured at end-diastole from the parasternal long-axis views of 3 cardiac cycles with Aloka Alfa 6 equipment (Japan), by 2 cardiologists who were unaware of the clinical data. Metabolic syndrome was defined according with the International Diabetes Federation criteria. The association between epicardial fat thicknesses with metabolic syndrome was evaluated with the fisher exact test, whereas its correlation with body
Looking for online definition of Shwachman-Diamond syndrome in the Medical Dictionary? Shwachman-Diamond syndrome explanation free. What is Shwachman-Diamond syndrome? Meaning of Shwachman-Diamond syndrome medical term. What does Shwachman-Diamond syndrome mean?
TY - JOUR. T1 - Greater trochanteric pain syndrome negatively affects work, physical activity and quality of life: a case control study. AU - Fearon, Angela. AU - Cook, Jillianne Leigh. AU - Scarvell, Jennie M. AU - Neeman, Teresa. AU - Cormick, Wes. AU - Smith, Paul N. PY - 2014. Y1 - 2014. N2 - Musculoskeletal injury causes pain and when chronic can affect mental health, employment and quality of life. This study examined work participation, function and quality of life in people with greater trochanteric pain syndrome (GTPS, n. =. 42), severe hip osteoarthritis (OA, n. =. 20) and an asymptomatic group (ASC, n. =. 23). No differences were found between the symptomatic groups on key measures, both were more affected than the ASC group, they had lower quality of life score (p.. AB - Musculoskeletal injury causes pain and when chronic can affect mental health, employment and quality of life. This study examined work participation, function and quality of life in people with greater trochanteric ...
TY - JOUR. T1 - Posterior reversible encephalopathy syndrome associated with hemodynamic augmentation in aneurysmal subarachnoid hemorrhage. AU - Giraldo, Elias A.. AU - Fugate, Jennifer E.. AU - Rabinstein, Alejandro A.. AU - Lanzino, Giuseppe. AU - Wijdicks, Eelco F.M.. PY - 2011/6/1. Y1 - 2011/6/1. N2 - Background: Cerebral vasospasm has become the most concerning complication in patients with aneurysmal subarachnoid hemorrhage (aSAH) seen in the neurosciences intensive care unit (NSICU). Hemodynamic augmentation is frequently used to treat cerebral ischemia from vasospasm. In the last 5 years, posterior reversible encephalopathy syndrome (PRES) has been reported in three single case reports as a complication of hemodynamic augmentation. We describe an additional three patients seen in our institution. Methods: Description of clinical course of three patients with a secured aneurysm treated with hemodynamic augmentation for cerebral vasospasm. Results: We identified three patients (two female ...
TY - JOUR. T1 - Plasma phospholipid fatty acid composition and estimated desaturase activity in heart failure patients with metabolic syndrome. AU - Lee, Seungmin. AU - Do, Hyun Ju. AU - Kang, Seok Min. AU - Chung, Ji Hyung. AU - Park, Eunju. AU - Shin, Min Jeong. PY - 2012/9. Y1 - 2012/9. N2 - Metabolic syndrome is one of the major factors to increase the incidence of heart failure. In our study, we compared plasma fatty acid compositions among heart failure patients with and without Metabolic syndrome. Fatty acid (FA) composition of plasma phospholipids was analyzed and the activities of desaturase were estimated as the ratio of substrate and product fatty acids in 85 stable heart failure patients. Fatty acid and estimated desaturase activities were further examined for their associations with Metabolic syndrome components. Heart failure patients with Metabolic syndrome showed significant changes in fatty acid composition in comparison to those without Metabolic syndrome, which had a decreased ...
The pathophysiology of fat embolism syndrome has not yet been definitively characterized. A mechanical theory holds that the embolization event results from a transient rise in pressure in a fat-containing cavity in association with torn blood vessels, allowing escape of marrow or adipose fat cells into the circulation.Two alternative biochemical theories posit explanations for fat embolism syndrome, both of which could account for the observation of the syndrome in nontraumatic settings. In one, fat droplets already in the circulation are broken down at distal sites to free fatty acids, which then exert a local toxic effect on the tissues. This theory explains the appearance of petechiae and the histologic changes in pneumocytes in association with fat-embolism-induced acute respiratory distress syndrome (ARDS).The obstructive explanation for fat embolism syndrome proposes that free fatty acids are mobilized by circulating catecholamines. Fat droplets in the circulation eventually coalesce and ...
Meibomian gland dysfunction patients with novel Sjogren's syndrome biomarkers benefit significantly from a single vectored thermal pulsation procedure: a retrospective analysis Alice T Epitropoulos,1,2 Krysta Goslin,2 Raman Bedi,3 Caroline A Blackie4 1Ophthalmic Surgeons and Consultants of Ohio, The Eye Center of Columbus, 2The Ohio State University Wexner Medical Center, Department of Ophthalmology, Columbus, OH, USA; 3Iris Advanced Eye Centre, Chandigarh, India; 4TearScience Inc., Morrisville, NC, USA Purpose: To measure the effects from a single vectored thermal pulsation treatment of the meibomian glands on dry eye signs and symptoms in patients who tested positively versus negatively for novel Sjögren's syndrome (SS) biomarkers. Methods: The retrospective study included the deidentified data of 102 eyes of 59 patients with dry eye and meibomian gland dysfunction (MGD), who were also tested for novel biomarkers for SS and underwent a single 12-minute LipiFlow thermal pulsation procedure. All
TY - JOUR. T1 - Metabolic syndrome and angiographic coronary artery disease prevalence in association with the framingham risk score. AU - Konstantinou, Dimitris M.. AU - Chatzizisis, Yiannis S.. AU - Louridas, George E.. AU - Giannoglou, George D.. PY - 2010/6/1. Y1 - 2010/6/1. N2 - Background: The association of metabolic syndrome with coronary artery disease (CAD) has been studied extensively. However, little is known about the effect of Framingham risk score (FRS) and metabolic syndrome components on the association of metabolic syndrome with angiographically significant CAD. Our aim was to investigate whether that relationship is influenced by individual's 10-year CAD risk profile as assessed by FRS. Furthermore, we sought to elucidate whether metabolic syndrome is associated with angiographically significant CAD independently of its individual components. Methods: We studied a consecutive sample of 150 patients undergoing coronary angiography for the evaluation of chest pain. Metabolic ...
BACKGROUND AND OBJECTIVES: Optic neuritis or longitudinally extensive myelitis in Sjogren syndrome (SS) suggests a neuromyelitis optica spectrum disorder (NMOSD). However, brain abnormalities of SS remain to be elucidated for the association with neuromyelitis optica (NMO). METHODS: Twelve primary SS patients (all women, 42 +/- 13.2 years) who had recurrent central nervous system (CNS) manifestations with brain involvement were retrospectively identified. Brain MRI, and neurologic and serologic findings were analyzed with the measurement of anti-aquaporin-4 antibody (AQP4-Ab). RESULTS: All patients showed brain lesions characteristic of NMO as follows: 1) the involved sites adjacent to the third and fourth ventricles and in the posterior limb of the internal capsule, 2) unique configurations, such as the longitudinal course from the internal capsule to the midbrain, large cerebral or cerebellar lesions over 3 cm, and cavity-like formations. AQP4-Ab was positive in six of eight patients tested, and all
Minor Salivary Glands: There are over 600 minor salivary glands in the Oral Cavity. They are of 2 Types: Mucous Producing Minor Salivary Glands Serous Fluid Producing Minor Salivary Glands Location Of Minor Salivary Glands: Minor salivary glands are found in large numbers on the Cheeks on all side of the Oral cavity which cannot [&hellip
The anterior thalamic nuclei are important for spatial and episodic memory, however, surprisingly little is known about the status of these nuclei in neurological conditions that present with memory impairments, such as Down syndrome. We quantified neurons and glial cells in the anterior thalamic nuclei of four older patients with Down syndrome. There was a striking reduction in the volume of the anterior thalamic nuclei and this appeared to reflect the loss of approximately 70% of neurons. The number of glial cells was also reduced but to a lesser degree than neurons. The anterior thalamic nuclei appear to be particularly sensitive to effects of aging in Down syndrome and the pathology in this region likely contributes to the memory impairments observed. These findings reaffirm the importance of examining the status of the anterior thalamic nuclei in conditions where memory impairments have been principally assigned to pathology in the medial temporal lobe ...
Idiopathic membranous nephropathy is the most common cause of nephrotic syndrome in adults. Over the past decade, a number of studies have reported therapeutic efficacy for treatment with tacrolimus plus steroid in patients with nephrotic syndrome including patients with membranous nephropathy. This study will evaluate the safety and effectiveness of a traditional herbal extraction, Tripterygium wilfordii, plus steroid in reducing the amount of protein in the urine in patients with membranous nephropathy. A hundred patients with biopsy-proven membranous nephropathy will be recruited. They will be screened with a medical history, physical examination, blood tests, and an examination for infection, cancers, and other conditions that can cause membranous nephropathy. The investigators plan to conduct an open-label study of the efficacy and safety of Tripterygium wilfordii in the treatment of membranous nephropathy. Half of them will be treated with oral Tripterygium wilfordii plus steroids for 6 ...
Pashayan syndrome also known as Pashayan-Prozansky Syndrome, and blepharo-naso-facial syndrome is a rare syndrome. Facial abnormalities characterise this syndrome as well as malformation of extremities. Specific characteristics would be a bulky, flattened nose, where the face has a mask like appearance and the ears are also malformed. A subset of Pashayan syndrome has also been described, known as "cerebrofacioarticular syndrome", "Van Maldergem syndrome'" or "Van Maldergem-Wetzburger-Verloes syndrome". Similar symptoms are noted in these cases as in Pashayan syndrome. "OMIM Entry - 110050 - BLEPHARONASOFACIAL MALFORMATION SYNDROME". omim.org. Retrieved 4 August 2017. Bissonnette, Bruno; Luginbuehl, Igor; Dalens, Bernard J.; Marciniak, Bruno (2006). Bruno Bissonnette, ed. Syndromes: rapid recognition and perioperative management. McGraw-Hill. ISBN 978-0-07-135455-4. [page needed] Stoll (1999). "A three generations family with blepharo-naso-facial malformations suggestive of Pashayan syndrome". ...
Elevated plasma cholesterol (hypercholesterolemia) and various other plasma lipid imbalances (dyslipidemias) are major risk factors for coronary heart disease. Patients with hypercholesterolemia have elevated low-density lipoprotein cholesterol, which leads to atherosclerotic deposition of cholesterol in the arterial walls. As identified by the National Cholesterol Education Program Adult Treatment Panel III, lowering the low-density lipoprotein cholesterol plasma concentration effectively reduces cardiovascular morbidity and mortality and is essential for the prevention and management of coronary heart disease.. Currently, 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (statins) are the first-line monotherapies prescribed to reduce low-density lipoprotein cholesterol, after diet and therapeutic lifestyle change. However, low doses of statins often fail to produce the ATP III-recommended levels of low-density lipoprotein cholesterol reduction, making it necessary to increase the dose ...
The patient was treated with high protein intake, dipyramidol and captopril; both right lung cysts were resected, followed by the left pulmonary cyst 4 weeks later. Hydatid cyst was confirmed histopathologically. He recovered well, the serum ELISA for echinococcus became negative, and follow-up urine examination and thoracic computerised tomography were normal 6 months after surgery, confirming good renal recovery and absence of pulmonary hydatid disease. Discussion. Renal involvement during hydatid disease is well recognised.1 The most common manifestation is proteinuria, with or without nephrotic syndrome. Several histopathological types have been demonstrated.1-3 The pathogenesis of glomerular disease in patients with hydatid disease is not well understood, with most supporting an immune complex-mediated mechanism. Echinococcal antigen and corresponding antibody in the glomeruli have been demonstrated by immunoperoxidase studies.4 The site of the hydatid cyst appears to be crucial in the ...
article{1e9e7fa6-4990-4ef4-af96-b18ff9968d5d, abstract = {,p,Anaphylaxis/anaphylactoid reactions have recently been reported after few treatments with factor IX concentrates in patients with haemophilia B at the same time as inhibitors to factor IX were demonstrated. In some of these cases nephrotic syndrome has appeared during immune tolerance induction (ITI) with high doses of factor IX concentrates. Gene deletions seem to be associated with a high risk of developing antibodies to factor IX. This report presents two brothers with deletion of 1 bp in exon f of the factor IX gene. Both showed anaphylactoid reactions and they were desensitized using slow i.v. injections of factor IX. At the time of anaphylaxis, inhibitors of factor IX in a low titre could be demonstrated. The elder brother responded well after a short time on ITI and has no spontaneous bleedings on regular prophylaxis although in a somewhat higher dose than expected. On the other hand, in spite of comparable regimens, the younger ...
TY - JOUR. T1 - Long-Term Dietary Nitrate Supplementation Does Not Prevent Development of the Metabolic Syndrome in Mice Fed a High-Fat Diet. AU - Matthews, V. B.. AU - Hollingshead, R.. AU - Koch, H.. AU - Croft, K. D.. AU - Ward, N. C.. PY - 2018/1/1. Y1 - 2018/1/1. N2 - Background. Nitric oxide (NO) is an important vascular signaling molecule that plays a role in vascular homeostasis. A reduction in NO bioavailability is thought to contribute to endothelial dysfunction, an early risk factor for both cardiovascular disease and type 2 diabetes. Dietary nitrate, through the nitrate-nitrite-NO pathway, may provide an alternate source of NO when the endogenous eNOS system is compromised. In addition to a role in the vascular system, NO may also play a role in the metabolic syndrome including obesity and glucose tolerance. Aim. To investigate the effect of long-term dietary nitrate supplementation on development of the metabolic syndrome in mice fed a high-fat diet. Methods. Following 1 week of ...
The mechanism responsible for trafficking of monocyte-derived macrophages into kidney in the puromycin aminonucleoside model of nephrotic syndrome in rats (PAN-NS), and the significance of this infiltration, remain largely unknown. CXCL10, a chemokine secreted in many T helper type 1 (Th1) inflammatory diseases, exhibits important roles in trafficking of monocytes and activated T cells. We hypothesized that induction of circulating interferon (IFN)- and glomerular tumour necrosis factor (TNF)- during PAN-NS would stimulate the release of CXCL10 by podocytes, leading to infiltration of activated immune cells and greater glomerular injury. We found that serum IFN-, glomerular Cxcl10mRNA and intra- and peri-glomerular macrophage infiltration were induced strongly during the late acute phase of PAN-NS in Wistar rats, but not in nude (Foxn1(rnu/rnu)) rats lacking functional effector T lymphocytes. Wistar rats also developed significantly greater proteinuria than nude rats, which could be ab...olished ...
Objective To establish an algorithm for first-trimester combined screening for trisomy 21 with biochemical testing from 7 to 14 weeks' gestation and ultrasound testing at 11-13 weeks. Methods This was a multicenter study of 886 pregnancies with trisomy 21 and 222 475 unaffected pregnancies with measurements of free beta-human chorionic gonadotropin (beta-hCG) and pregnancy-associated plasma protein-A (PAPP-A) at 7-14 weeks' gestation. Multiple regression modeling of log-transformed marker values was used to produce log multiples of the median (MoM) values for PAPP-A and free beta-hCG. The models included terms for the center attended and the machine used for biochemical analysis, gestational age, maternal racial origin, maternal weight, smoking status and method of conception. Bivariate Gaussian distributions were fitted to log MoM PAPP-A and log MoM free beta-hCG in trisomy 21 and in unaffected pregnancies. In each case the patient-specific risk for trisomy 21 was estimated by multiplying the ...
Menopause transition is associated with detrimental changes in physical activity, body composition and metabolic profile. Although physical activity energy expenditure (PAEE) is inversely associated with metabolic syndrome (MetS) in individuals at higher risk of CVD, the association is unknown in low-risk individuals. The aim of the study was to investigate the association between PAEE and MetS (prevalence and severity) in inactive overweight or obese postmenopausal women with a low Framingham Risk Score (FRS:, 10%). Cross-sectional data of 126 participants were divided into quartiles based on PAEE (Q1= lowest PAEE) while fat-free mass (FFM) and fat mass (FM) were measured by DXA. MetS prevalence was significantly different between Q1 and Q4 (37.9% vs 13.3%, p= 0.03). After controlling for potential confounders, MetS severity was negatively associated with PAEE (B= -0.057, p, 0.01) and positively with FFM (B= 0.038, p, 0.001). Moderation analyses indicated that a greater FFM exacerbated the ...
Press Release issued Mar 2, 2015: Clinical trial report, 'Keratoconjunctivitis sicca (Dry Eye) Global Clinical Trials Review, H1, 2015'' provides data on the Keratoconjunctivitis sicca (Dry Eye) clinical trial scenario. This report provides elemental information and data relating to the clinical trials on Keratoconjunctivitis sicca (Dry Eye). It includes an overview of the trial numbers and their recruitment status as per the site of trial conduction across the globe. The databook offers a preliminary coverage of disease clinical trials by their phase, trial status, prominence of the sponsors and also provides briefing pertaining to the number of trials for the key drugs for treating Keratoconjunctivitis sicca (Dry Eye). This report is built using data and information sourced from proprietary databases, primary and secondary research and in-house analysis by GlobalData's team of industry experts.
Does Noonan Syndrome Increase Malignant Hyperthermia Susceptibility : Topic Does Noonan Syndrome Increase Malignant Hyperthermia Susceptibility Robert Shaw (medical student), Ari Weintraub, MD, Ronald Litman, DO
Looking for information on Dog Keratoconjunctivitis Sicca (KCS) in Salt Lake City? We have compiled a list of businesses and services around Salt Lake City that should help you with your search. We hope this page helps you find information on Dog Keratoconjunctivitis Sicca (KCS) in Salt Lake City.
There are patterns of unusual facial features that occur in recognizable syndromes. Some of these craniofacial syndromes are genetic, others are from unknown causes. In many craniofacial syndromes, the features that are unusual involve the nose, mouth, and jaw, or resting muscle tone, and put the individual at risk for OSA syndrome. Down syndrome is one such syndrome. In this chromosomal abnormality, several features combine to make the presence of obstructive sleep apnea more likely. The specific features of Down syndrome that predispose to obstructive sleep apnea include relatively low muscle tone, narrow nasopharynx, and large tongue. Obesity and enlarged tonsils and adenoids, conditions that occur commonly in the western population, are much more likely to be obstructive in a person with these features than without them. Obstructive sleep apnea does occur even more frequently in people with Down syndrome than in the general population. A little over 50% of all people with Down syndrome ...
Western diets are characterized by both dietary omega-3 fatty acid deficiency and increased fructose intake. The latter found in high amounts in added sugars such as sucrose and high fructose corn syrup (HFCS). Both a low intake of omega-3 fatty acids or a high fructose intake contribute to metabolic syndrome, liver steatosis or non-alcoholic fatty liver disease (NAFLD), promote brain insulin resistance, and increase the vulnerability to cognitive dysfunction. Insulin resistance is the core perturbation of metabolic syndrome. Multiple cognitive domains are affected by metabolic syndrome in adults and in obese adolescents, with volume losses in the hippocampus and frontal lobe, affecting executive function. Fish oil supplementation maintains proper insulin signaling in the brain, ameliorates NAFLD and decreases the risk to metabolic syndrome suggesting that adequate levels of omega-3 fatty acids in the diet can cope with the metabolic challenges imposed by high fructose intake in Western diets which is
OBJECTIVE: To assess the transactive response DNA-binding protein 43 (TDP-43) burden in familial forms of Alzheimer disease (FAD) and Down syndrome (DS) to determine whether TDP-43 inclusions are also present. DESIGN: Using standard immunohistochemical techniques, we examined brain tissue samples from 42 subjects with FAD and 14 with DS. RESULTS: We found pathological TDP-43 aggregates in 14.0% of participants (6 of 42 and 2 of 14 participants with FAD and DS, respectively). In both FAD and DS, TDP-43 immunoreactivity did not colocalize with neurofibrillary tangles. Occasionally participants with FAD or DS had TDP-43-positive neuropil threads or dots. Overall, the amygdala was most commonly affected, followed by the hippocampus, with no TDP-43 pathology in neocortical regions. A similar distribution of TDP-43 inclusions is seen in sporadic Alzheimer disease, but it differs from that seen in amyotrophic lateral sclerosis and frontotemporal dementia. CONCLUSIONS: Transactive response DNA-binding ...
Inflammatory pseudotumour is a rare condition that can affect various organs. The clinical and histologic appearance of the pseudotumour may mimic haematological, lymphoproliferative, paraneoplastic or malignant processes. A previously healthy 39-year-old man presented with nephrotic syndrome. He had a history of headaches, nausea and swollen ankles. Computed tomography of the abdomen revealed a 6-cm mass in the spleen. Following a renal biopsy, a diagnosis of membranoproliferative glomerulonephritis (MPGN) type I was made. Splenectomy was performed and the examination revealed a mixed population of lymphocytes with predominantly T-cells, B-cells and lymphoplasmacytoid cells. Immunostaining confirmed that the small cells were mostly T-cells positive for all T-cell markers including CD2, CD3, CD4, CD5, CD7 and CD8. A diagnosis of inflammatory pseudotumour was established. The removal of the spleen was followed by remission of glomerulonephritis, but it was complicated by a subphrenic abscess and ...
Here, we present a 67-year-old Japanese man who developed insidious-onset nephrotic syndrome. He had a history of occupational asbestos exposure for about 8 years during his 30s, and was found to have pleural effusion 3 years before his present illness. At that time, repeated cytology testing of his pleural effusion found no malignant cells, and pleural biopsy found fibrous pleuritis without evidence of malignant mesothelioma. Percutaneous kidney biopsy found massive deposits of AA-type amyloid in the glomeruli, small arteries, and medulla. Computed tomography showed a calcified mass in the right lower lung that was positive for 67Ga uptake, but transbronchial lung biopsy and bronchoalveolar lavage found no evidence of malignancy. He was diagnosed with rounded atelectasis and diffuse pleural thickening. As these benign asbestos-related diseases have no standard treatment, we administered low-dose angiotensin II receptor blocker to preserve kidney function. Unfortunately, his nephrotic syndrome ...
TY - JOUR. T1 - Radiologic manifestations of the systemic autoimmune diseases. AU - Primack, Steven. AU - Muller, N. L.. PY - 1998. Y1 - 1998. N2 - Advances in thoracic imaging during the past two decades, such as CT scans and MR imaging, have enhanced our understanding of the pleuropulmonary abnormalities that develop in the systemic autoimmune diseases. In this article, the thoracic radiologic manifestations of several connective tissue diseases (systemic lupus erythematosus, rheumatoid arthritis, Sjogren's syndrome, polymyositis/dermatomyositis, progressive systemic sclerosis, and anklyosing spondylitis), two granulomatous vasculitides, (Wegener's Granulomatosis and Churg-Strauss syndrome), and antiglomerular basement membrane disease are reviewed.. AB - Advances in thoracic imaging during the past two decades, such as CT scans and MR imaging, have enhanced our understanding of the pleuropulmonary abnormalities that develop in the systemic autoimmune diseases. In this article, the thoracic ...
Purpose: Farming has been previously associated with the autoimmune rheumatic diseases (ARD), including rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The exposure(s) underlying this association are not well-understood, and few studies have directly addressed the role of pesticides, including personal and residential insecticide use. Method: Using data from the Women's Health Initiative Observational Study (n=76,861, aged 50-79 years), we examined self-reported lifetime personal or commercial residential insecticide use and having lived or worked on a farm in relation to risk of incident ARD, confirmed by use of disease modifying anti-rheumatic drugs at year 3 of follow-up (n=213; 178 with RA only, 27 with SLE only, and 8 with both RA and SLE), and excluding unconfirmed cases. Hazard ratios (HR) and 95% confidence intervals (CI) were estimated by multivariate models adjusting for age and covariates, including race, region, education, occupation, history of smoking, asthma, ...
Juvenile polyposis syndrome (JPS) is a hereditary condition identified by the presence of non-cancerous polyps in the GI tract, most commonly in the colon.
Manuscript Accepted: 16 SEP 2013. Keywords: HBV; inactive carriers; metabolic syndrome; fibrosis; FibroScan. Abstract\. Background and Aim. There are few data of fibrosis development in chronic hepatitis B (CHB) patients classified as inactive carriers. The aim of this study is to determinate the prevalence of significant fibrosis and probable cirrhosis measured by FibroScan in real inactive CHB carriers and investigate the relationship with virological, epidemiological and metabolic factors.. Methods. Cross-sectional cohort study including CHB inactive carriers. Liver stiffness measurement was performed with transient elastography (FibroScan). Significant fibrosis (≥F2) was defined as stiffness ,7.5 kPa, and probable cirrhosis as ,11.8 kPa. Factors associated with significant fibrosis were explored with univariate and multivariate adjusted logistic regression analyses.. Results. 96 CHB inactive carriers were analyzed. Of them, 24 (25%) had significant fibrosis and 7 (7%) probable cirrhosis; ...
article{73612c79-faf0-4985-94ba-877f422e6fa5, abstract = {Objective: In this study we aimed to estimate the magnitude of a possible increase in risk of adverse outcome in fetuses with normal karyotype and increased nuchal translucency (NT), and to determine bow well NT measurements can distinguish between fetuses with normal and adverse outcome. Methods: We studied 16260 consecutive fetuses with normal karyotype derived from an unselected pregnant population. The following cut-offs for increased risk of adverse outcome were chosen a priori: NT >= 95(th) percentile, >= 3 mm, >= 3.5 mm, and >= 4.5 mm. The positive and negative likelihood ratios (+LR, -LR) of the risk cut-offs with regard to fetal malformation, miscarriage, perinatal death, termination of pregnancy and total adverse outcome were calculated, and receiver-operating characteristics (ROC) curves were drawn. Results: The total rate of adverse outcome was 2.7%. +LR and -LR of NT >= 3.0 mm were: for lethal or severe ...