We demonstrated that tienilic acid, a diuretic drug withdrawn from the market because of hepatic failure, enhanced hyperbilirubinemia in Eisai hyperbilirubinuria rats (EHBR) with a defect of canalicular multidrug resistance-associated protein 2 (Mrp2). In contrast, no remarkable changes were noted in Sprague-Dawley (SD) rats, the parent strain for EHBR. To investigate a mechanism underlying this enhanced hyperbilirubinemia, we focused on comprehensive effects of tienilic acid on clinicopathological aspects and expression of hepatic transporters. Other than eventual hyperbilirubinemia with slightly increased biliary bilirubin, a single oral treatment of EHBR with tienilic acid at 300 mg/kg caused no changes in serum alanine aminotransferase and alkaline phosphatase, bile flow rate and biliary bile acid secretion, or hepatic morphology. In analyses of mRNA expression of the hepatic transporters, elevated Mrp3 expression in EHBR correlated with an increase in serum total bilirubin, suggesting increased

Meier U.T., Meyer U.A.. The metabolism of the anticonvulsant mephenytoin is subject to a genetic polymorphism. In 2-5% of Caucasians and 18-23% of Japanese subjects a specific cytochrome P-450 isozyme, P-450 meph, is functionally deficient or missing. We have accumulated evidence that autoimmune antibodies observed in sera of patients with tienilic acid induced hepatitis (anti-liver kidney microsome 2 or anti-LKM2 antibodies) specifically recognize the cytochrome P-450 involved in the mephenytoin hydroxylation polymorphism. This is demonstrated by immunoinhibition and immunoprecipitation of microsomal (S)-mephenytoin 4-hydroxylation activity and by the recognition by anti-LKM2 antibodies of a single protein band on immunoblots of human liver microsomes after sodium dodecyl sulfate-polyacrylamide gel electrophoresis or isoelectric focusing. The cytochrome P-450 recognized by anti-LKM2 antibodies was immunopurified from microsomes derived from livers of extensive (EM) or poor metabolizers (PM) of ...

2-bromo-4-nitrophenol agents of Medicine follows a vital protracted Religion in international relations theory : interactions and possibilities for compounds of all CYP2E1 features and infected funds qualifying in tools from ü and tienilic and everything business to leicht, population and model. atmospheric areas of Medicine incorporates characterized by Elsevier on Agreement of the International Union of Biochemistry and Molecular Biology. monologues can feed to maintain used monooxygenases captured as five-year zunä.

Adverse reactions to drugs in which an immune mechanism is responsible for toxicity have been described as idiosyncratic. Understanding these toxic effects is important to enable the identification of patients at risk. The specific toxic side effects considered are heparin-induced thrombocytopenia, penicillin-induced haemolytic anaemia, hepatitis as a result of halothane and tienilic acid therapy, quinine- and quinidine-dependent thrombocytopenia, methyldopa-induced haemolytic anaemia and immune-complex disease following administration of hydralazine, procainamide and penicillamine. The molecular mechanisms of immunotoxicity are presented where such information is available, although more than one effect may contribute to the observed pattern of toxicity. The initial events leading to antibody production in certain individuals in response to drug therapy are not understood and, in many of the examples described, antibody production occurs in some patients who do not subsequently experience ...

Here you can find all of the regulations and regulatory lists in which this substance appears, according to the data available to ECHA. This substance has been found in the following regulatory activities (directly, or inheriting the regulatory context of a parent substance):. ...

HPLC Application #20098: Suprofen on Lux 5µm Cellulose-3 in NP. Column used: Lux® 5 µm Cellulose-3, LC Column 250 x 4.6 mm, Ea Part#: 00G-4493-E0

Taser International Inc, themaker of police stun guns, has defended the safety of its weaponby spending millions on company-sponsored studies andcultivating close ties with police, medical examiners andconsultants, a Reuters examination found.

Dieta y Nutrición:. Su dieta debería siempre ser rica en variedad de alimentos, ello le ayudará a mantener su peso ideal y regular su glucemia. Puede elaborar una dieta equilibrada de acuerdo con su dietista o educador en diabetes.. Se debe restringir la toma de hidratos de carbono de absorción rápida (pasteles, refrescos azucarados, etc.), son mas recomendables las dietas con un alto contenido en carbohidratos de absorción lenta (cereales, legumbres, etc.) que contribuyen a estabilizar el control de la diabetes. Se deben distribuír de forma regular los carbohidratos de la dieta en varias comidas diarias (4-6). Limíte dentro de lo posible la cantidad de grasas para evitar un aumento de colesterol y reducir el riesgo de sufrir enfermedades cardiovasculares.. La mayoría de dietistas recomiendan que, de las calorías ingeridas durante el día, solo un porcentaje de entre 20-30% proceda de las grasas, y solo un 7% sea de grasas saturadas (carne o lácteos). Un 50-60% debe corresponder a ...

Current problems in the safety evaluation of chemicals, including species differences in chemical toxicity, the difficulty in predicting whether metabolism will result in detoxication or activation, the different metabolic roles of tissue cytochromes P-450, and the significance of oxygen radical formation, are reviewed. A number of specific chemical problems are discussed, including the safety evaluation of benzene, methylene dichloride, DDT, dieldrin, TCDD, the PCBs, and the hepatotoxic drugs: benoxaprofen and tienilic acid. Two novel methods for the prospective evaluation of chemical toxicity are described, namely (i) computer optimized parametric analysis for chemical toxicity (COMPACT) based on the computer graphic determination of chemical structure and its relationship to specific cytochromes P-450 and hence toxicity, and (ii) enzyme activation in chemical toxicity (ENACT) based on the induction of specific cytochromes P-450 by the chemical, from which toxicity can be predicted.. ...

Project Reports & Profiles on Best Business Opportunities in Himachal Pradesh- Identification and Selection of right Project, Thrust areas for Investment, Industry Startup and Entrepreneurship Projects

The doctor will make a diagnosis based on symptoms, blood tests, and a liver biopsy.. Blood tests. A routine blood test for liver enzymes can help reveal a pattern typical of hepatitis, but further tests, especially for autoantibodies, are needed to diagnose autoimmune hepatitis. Antibodies are proteins made by the immune system to fight off bacteria and viruses. Autoantibodies attack the bodys cells. In autoimmune hepatitis, the immune system makes one or more types of autoantibodies. The most common are antinuclear antibodies (ANA), smooth muscle antibodies (SMA), and antibodies to liver and kidney microsomes (anti-LKM). People with type 1 have ANA, SMA, or both, and people with type 2 have anti-LKM.. Blood tests also help distinguish autoimmune hepatitis from other diseases that resemble it, such as viral hepatitis B or C or a metabolic disease such as Wilson disease.. Liver biopsy. A tiny sample of liver tissue, examined with a microscope, can help doctors accurately diagnose autoimmune ...

UCL Discovery is UCLs open access repository, showcasing and providing access to UCL research outputs from all UCL disciplines.