3-Iodothyronamine (T1AM) is an endogenous thyronamine. T1AM is a high-affinity ligand for the trace amine-associated receptor TAAR1 (TAR1, TA1), a recently discovered G protein-coupled receptor.[1][2] T1AM is the most potent endogenous TAAR1 agonist yet discovered.[3] Activation of TAAR1 by T1AM results in the production of large amounts of cAMP. This effect is coupled with decreased body temperature and cardiac output.[4] Wu et al. have pointed out that this relationship is not typical of the endocrine system, indicating that TAAR1 activity may not be coupled to G-proteins in some tissues, or that T1AM may interact with other receptor subtypes.[3] T1AM may be part of a signaling pathway to modulate cardiac function, as the compound can induce negative inotropic effects and decrease cardiac output.[5] ...
Recent evidence suggests that the trace amine-associated receptor 1 (TAAR1) plays a pivotal role in the regulation of dopamine (DA) transmission and psychostimulant action. Several selective TAAR1 agonists have previously shown efficacy in models of cocaine addiction. However, the effects of TAAR1 activation on methamphetamine (METH)-induced behaviours are less well understood, as indeed are the underlying neurochemical mechanisms mediating potential interactions between TAAR1 and METH. Here, in a progressive ratio schedule of reinforcement the partial TAAR1 agonist, RO5263397, reduced the break-point for METH self-administration, while significantly increasing responding maintained by food reward. Following self-administration and extinction training, RO5263397 completely blocked METH-primed reinstatement of METH seeking. Moreover, when used as a substitute, unlike a low dose of METH, which sustained vigorous responding when substituting for the training dose of METH, RO5263397 was not self
The thyronamines function via some unknown mechanism to inhibit neuronal activity; this plays an important role in the hibernation cycles of mammals. One effect of administering the thyronamines is a severe drop in body temperature. Iodide is actively absorbed from the bloodstream and concentrated in the thyroid follicles. (If there is a deficiency of dietary iodine, the thyroid enlarges in an attempt to trap more iodine, resulting in goitre.) Via a reaction with the enzyme thyroperoxidase, iodine is covalently bound to tyrosine residues in the thyroglobulin molecules, forming monoiodotyrosine (MIT) and diiodotyrosine (DIT). Linking two moieties of DIT produces thyroxine. Combining one particle of MIT and one particle of DIT produces triiodothyronine. Both T3 and T4 are used to treat thyroid hormone deficiency (hypothyroidism). They are both absorbed well by the gut, so can be given orally. Levothyroxine, the most commonly used synthetic thyroxine form, is a stereoisomer of physiological ...
On Thursday, December 28th, 2017, researchers at Nanyang Technological University in Singapore announced theyd developed a skin path that delivers anti-obesity drugs to the body with a lower risk of side effect than that associated with the same drugs (including a thyroid hormone derivative) when they are administered via injection or swallowed in a pill.. However, there are similarities with an injection because the ingredients are housed in hundreds of micro-needles that embed in the skin when the slimming patch is applied and the degrade in a manner that feeds the white adipose tissue below the skin a drug that causes it to turn brown.. Researchers at Columbia University Medical Center in New York are working on something similar. The needles deliver nanoparticles that change the fat near the patch application area and, when details of the project hit the news in September 2017, it sparked a lot of interest.. Both micro-needle patches have been tested on mice. The researchers in Singapore ...
ENCODES a protein that exhibits trace-amine receptor activity (ortholog); INVOLVED IN sensory perception of chemical stimulus (ortholog); FOUND IN integral component of membrane (inferred); plasma membrane (inferred); INTERACTS WITH 17beta-estradiol; bisphenol A; 2,3,7,8-tetrachlorodibenzodioxine (ortholog)
The KOMP Repository is located at the University of California Davis and Childrens Hospital Oakland Research Institute. Question? Comments? For Mice, Cells, and germplasm please contact us at [email protected], US 1-888-KOMP-MICE or International +1-530-752-KOMP, or for vectors [email protected] or +1-510-450-7917 ...
The KOMP Repository is located at the University of California Davis and Childrens Hospital Oakland Research Institute. Question? Comments? For Mice, Cells, and germplasm please contact us at [email protected], US 1-888-KOMP-MICE or International +1-530-752-KOMP, or for vectors [email protected] or +1-510-450-7917 ...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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cdna:known chromosome:VEGA66:10:23970706:23971719:1 gene:OTTMUSG00000019210 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:Taar5 description:trace amine-associated receptor 5 ...
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Thank you for the report. I can not repeat described behavior with test data. Please provide several rows bug is repeatable with. Results with my test data: CREATE TABLE `postac_blokada` ( `id` int(11) NOT NULL auto_increment, `postac_id` int(11) NOT NULL, `opis` varchar(255) collate utf8_polish_ci NOT NULL, `data` datetime NOT NULL, `status` tinyint(1) NOT NULL, PRIMARY KEY (`id`), KEY `postac_blokada_postac_id` (`postac_id`) ) ENGINE=InnoDB DEFAULT CHARSET=utf8 COLLATE=utf8_polish_ci ; insert into postac_blokada (postac_id, opis, data, status) values(1, t1, 2008-10-03 01:01:01, 0); insert into postac_blokada (postac_id, opis, data, status) values(2, t2, 2008-10-03 01:01:02, 1); insert into postac_blokada (postac_id, opis, data, status) values(1, t3, 2008-10-03 01:01:03, 1); insert into postac_blokada (postac_id, opis, data, status) values(2, t4, 2008-10-03 01:01:04, 0); SELECT `postac_blokada`.`id`, `postac_blokada`.`postac_id`, `postac_blokada`.`opis`, `postac_blokada`.`data`, ...
The alumni circle of the Gooische Groningers is the first alumni circle founded by the Ubbo Emmius Fund (2009). The initiators of the alumni circle in t Gooi - and thus the founders of the alumni circles concept - are Frits van Bruggen, Pamela Boumeester, Rob Meuter, Bert van der Wijk, and Gerbrand Visser. The Gooische Groningers are happy to give back to the UG. That is why they jointly support Ellen Nollens research (Aging Biology, UMCG) on the genetic causes of Alzheimers, Parkinsons, and other brain disorders that arise during aging. During the meetings, she shares the latest developments in her research. In addition, the Gooische alumni invite guest speakers who have studied in Groningen. For example, Frank Hoekstra (CEO of order2cash), Frits van Bruggen (Director of ANWB), Roelof Joosten (CEO FrieslandCampina), Jan Lokin (Emeritus Professor of Roman Law and Legal History at the UG), and Harry Groen (lung specialist, UMCG) were previous guests. ...
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t Smisje Great Reserva is a Belgian Strong Dark Ale style beer brewed by Brouwerij Smisje in Oudenaarde, Belgium. 3.54 average with 38 ratings, reviews and opinions.
t Smisje Grande Reserva is a Belgian Strong Dark Ale style beer brewed by Brouwerij Smisje in Oudenaarde, Belgium. 3.7 average with 89 ratings, reviews and opinions.
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Among the many remarkable things that have happened since the COVID-19 pandemic began is that a lot of our usual medical care has simply stopped. According to a recent study, routine testing for cervical cancer, cholesterol, and blood sugar is down nearly 70% across the country. Elective surgeries, routine physical examinations, and other screening tests have been canceled or rescheduled so that p...
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perl use strict; use warnings; use Test::More; use Statistics::R; SKIP: { skip because tests hang on Win32 (bug #81159), 1 if $^O =~ /^(MS) +?Win32$/; ok my $R = Statistics::R-,new(); is $R-,run(q`a ,- 1;`), ; eval { $R-,run( qq`print(Hello);\nprint(ASDF)` ); }; #diag Diagnostic: \[email protected]\n; ok [email protected], Runtime error; is $R-,run(q`a ,- 1;`), ; ok $R = Statistics::R-,new(); eval { $R-,run( qq`print(Hello);\nprint ASDF` ); }; #diag Diagnostic: \[email protected]\n; ok [email protected], Syntax error; # Actual error message varies depending on locale is $R-,run(q`a ,- 1;`), ; use_ok t::FlawedStatisticsR; ok $R = t::FlawedStatisticsR-,new(); eval { $R-,run( qq`print(Hello);\ncolors,-c(red)` ); }; #diag Diagnostic: \[email protected]\n; ok [email protected], Internal error; # THIS IS LINE 40 !!! }; done_testing ...
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People say, \if we aren\t supposed to have Vitamin A, why do we have receptors for it?\ I have an answer that raises more questions...just …
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3,5-diiodothyronine, also known as D-O-(4-hydroxyphenyl)-3,5-diiodo-tyrosine or 3,5-diiodothyronine, (dl)-isomer, belongs to phenylalanine and derivatives class of compounds. Those are compounds containing phenylalanine or a derivative thereof resulting from reaction of phenylalanine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom. 3,5-diiodothyronine is practically insoluble (in water) and an extremely strong acidic compound (based on its pKa). 3,5-diiodothyronine can be found primarily in blood and urine, as well as in human brain tissue. Within the cell, 3,5-diiodothyronine is primarily located in the cytoplasm. Moreover, 3,5-diiodothyronine is found to be associated with hyperthyroidism, brain tumors, sepsis, and cirrhosis. 3,5-Diiodothyronine is a metabolite of thyroid hormones (thyroxine and triiodo-L-thyronine). It has specific actions and those actions do not involve thyroid hormone receptors (PMID 15807655 ...
1. Isolated livers from fed male rats were perfused for 2 h with T4 (L-thyroxine), T3 (L-3,3′,5-tri-iodothyronine) or rT3 (L-3,3′,5′-tri-iodothyronine) at different pH values (7.1-7.6) in a fully synthetic medium, whereby normal metabolic functions were maintained without addition of rat blood constituents or albumin. 2. T3 output into the medium and net T3 production reached a maximum at a pH of the medium of 7.2 and significantly decreased with alteration of the pH when livers were perfused with T4 as a substrate. 3. However, the net T4 and T3 uptake by the liver, as well as the hepatic T4 and T3 content after perfusion, were not dependent on the pH of the perfusion when livers were offered T4 or T3 as substrates respectively. 4. Determination of intracellular pH by the analysis of the distribution of the weak acid dimethyloxazolidinedione allows the conclusion that the pH optimum of iodothyronine 5′-deiodinase in the intact perfused liver corresponds to the maximum determined in vitro ...
in Journal of Clinical Investigation (1977), 60(6), 1230-9. l-Thyroxine is converted to 3,5,3-l-triiodothyronine (T(3)) as well as to 3,3,5-l-triiodothyronine (reverse T(3)). One product of further deiodination is 3,3-diiodothyronine (3,3T(2)). The serum ... [more ▼]. l-Thyroxine is converted to 3,5,3-l-triiodothyronine (T(3)) as well as to 3,3,5-l-triiodothyronine (reverse T(3)). One product of further deiodination is 3,3-diiodothyronine (3,3T(2)). The serum levels of reverse T(3) and 3,3T(2) change considerably in various physiological and disease states. We previously found that reverse T(3) and 3,3T(2) bind to the solubilized hepatic nuclear receptors for thyroid hormones. This led us to study binding and actions of these metabolites in cultured rat pituitary cells in which glucose consumption and growth hormone production are regulated by T(3) and l-thyroxine.Reverse T(3) and 3,3T(2) stimulated growth hormone production and glucose consumption and inhibited nuclear binding ...
Alterations reciprocal T3 and rT3 relationships are found in liver disease (Recenti Prog Med 1990;81:351-55), kidney disease (Ren Fail 1997; 19:129-136 Chung Kuo Chung Hsi I Chieh Ho Tsa Chih 1993;13:155-7) severe or systemic injury (Clin Endocrinol 1982;16:565) and toxic metal exposures (Comp Biochem Physiol C Pharmacol Toxicol Endocrinol 1999;123:39-44; J Appl Toxicol 1998;18:317-20; Toxicology 1997; 124:203-209; Occup Environ Med 1994;51:536-40). If we only use HRT via thyroid hormones to correct a deficiency in T3, a lot of scientific evidence tips the scales in the "false" direction with regard to this idea as the core issue of impaired T4 to T3 conversion is never addressed. The liver plays a dominant role in the metabolism of thyroid hormones via deiodination, conjugation, deamination, and decarboxylation enzymatic reactions. Correction of altered metabolism can significantly impact the quantity of thyroid hormone metabolites influencing cell function (Altern Med Rev 2000;5(4):306-33).The ...
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Stramrood, A. I., Huis In t Veld, E. M. J., van Pampus, M. G., Berger, L. W. A. R., Vingerhoets, A. J. J. M., Weijmar Schultz, W. C. M., van den Berg, P. P., van Sonderen, E. L. P. & Paarlberg, K. M., 2010, In : Journal of Psychosomatic Obstetrics and Gynecology. 31, 1, p. 40-49. Research output: Contribution to journal › Article › Scientific › peer-review ...
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Depending on my mood and weather and how much of a hurry I\m in, I either ride over the hill from Beaverton to downtown or I take MAX. But MAX cuts ~20 minutes off the trip, so I can\t blame people for doing it…. I work in Beaverton and live in North Portland and I\ve been playing around with going over the hill via Skyline/St Johns Bridge, but I\m still looking for a good route. Other than the fact that I had to walk part of my route today: the geometry on my bicycle prevents me from climbing steeper than certain grades if I don\t want to flip over backwards, it was actually a fairly fast trip. And #30, I actually do blame myself for that one, and that is a lot of the reason why I\m looking for a faster route that doesn\t require the train, (the other solution is to get a new job or a new house…). Until recently there was a bicycle only train from Beaverton TC to Goose Hollow that ran every 15 minutes. I mean, it wasn\t marked as such, (it actually had a big red sign that said ...
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Depending on my mood and weather and how much of a hurry I\m in, I either ride over the hill from Beaverton to downtown or I take MAX. But MAX cuts ~20 minutes off the trip, so I can\t blame people for doing it…. I work in Beaverton and live in North Portland and I\ve been playing around with going over the hill via Skyline/St Johns Bridge, but I\m still looking for a good route. Other than the fact that I had to walk part of my route today: the geometry on my bicycle prevents me from climbing steeper than certain grades if I don\t want to flip over backwards, it was actually a fairly fast trip. And #30, I actually do blame myself for that one, and that is a lot of the reason why I\m looking for a faster route that doesn\t require the train, (the other solution is to get a new job or a new house…). Until recently there was a bicycle only train from Beaverton TC to Goose Hollow that ran every 15 minutes. I mean, it wasn\t marked as such, (it actually had a big red sign that said ...
Immunogen conjugates comprising N-aminoalkyl derivatives of iodothyronines, e.g., thyroxine and its lower alkyl esters, coupled to an immunogenic carrier material, and antibodies raised against such immunogen conjugates.
A new study suggests that T cells from healthy donors recognize many neoantigens-mutant peptides on the surface of tumor cells, formed as a result of DNA damage-that are often neglected by a patients own immune system (Science 2016;352:1337-41). As such, it may be possible to "outsource" neoantigen-induced immune reactivity to donor T cells, and thereby enhance patients response to immunotherapy.. In a healthy immune system, the T-cell receptor (TCR) of each T cell has the capacity to recognize a different peptide, explains co-senior author Ton Schumacher, PhD, of the Netherlands Cancer Institute in Amsterdam: The bodys own peptides are overlooked, while foreign or mutated peptides trigger T cells to proliferate and mount an attack. However, in the weakened immune system of a patient with cancer, endogenous T cells may lose their ability to recognize tumor-expressed neoantigens as foreign. In this setting, according to this proof-of-principle study, outfitting patient T cells with TCRs from ...
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use TAP::Parser::Aggregator; my $aggregate = TAP::Parser::Aggregator-,new; $aggregate-,add( t/00-load.t, $load_parser ); $aggregate-,add( t/10-lex.t, $lex_parser ); my $summary = ,,END_SUMMARY; Passed: %s Failed: %s Unexpectedly succeeded: %s END_SUMMARY printf $summary, scalar $aggregate-,passed, scalar $aggregate-,failed, scalar $aggregate-,todo_passed ...
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Commenting on the governments proposals outlined in the Queens Speech today (Thursday), UNISON general secretary Dave Prentis said:
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