Resistance to thyroid hormone (RTH) is caused by mutations of the thyroid hormone receptor β (TRβ) gene. To understand the transcriptional program underlying TRβ mutant-induced phenotypic expression of RTH, cDNA microarrays were used to profile the expression of 11,500 genes in a mouse model of human RTH. We analyzed transcript levels in cerebellum, heart and white adipose tissue from a knock-in mouse (TRβPV/PV mouse) that harbors a human mutation (referred to as PV) and faithfully reproduces human RTH. Because TRβPV/PV mice have elevated thyroid hormone (T3), to define T3-responsive genes in the context of normal TRβ, we also analyzed T3 effects in hyperthyroid wild-type gender-matched littermates. Microarray analysis revealed 163 genes responsive to T3 treatment and 187 genes differentially expressed between TRβPV/PV mice and wild-type littermates. Both the magnitude and gene make-up of the transcriptional response varied widely across tissues and conditions. We identified genes modulated in T3

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REFERENCES. 1. Porter PMD. Westernizing Womens Risks? Breast cancer in lower-income countries. N Engl J Med. 2008;358(3):213-6. [ Links ] 2. Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, et al. Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2015;136(5):359-86. [ Links ] 3. Cheng SY. Thyroid hormone receptor mutations and disease: Beyond thyroid hormone resistance. Trends Endocrinol Metab. 2005;16(4):176-82. [ Links ] 4. Williams GR. Neurodevelopmental and neurophysiological actions of thyroid hormone. J Neuroendocrinol. 2008;20(6):784-94. [ Links ] 5. Moeller LC, Broecker-Preuss M. Transcriptional regulation by nonclassical action of thyroid hormone. Thyroid Res. 2011;4(Suppl 1):S6. [ Links ] 6. Bergh JJ, Lin H-Y, Lansing L, Mohamed SN, Davis FB, Mousa S, et al. Integrin AVB3 contains a cell surface receptor site for thyroid hormone that is linked to activation of mitogen-activated protein kinase and induction ...

I suppose transient autoimmune thyroiditis is possible, but again, TSH should Be suppressed. An RAIU would possibly help in Diagnosis, if high, or suppressed.. A TSHoma, and thyroid hormone resistance, are in theory possible, Can you get data from years ago, or on family members? Both diagnoses could be checked by a T3 suppression test, as described by Refetoff in his chapter in THYROIDMANAGER.ORG on RTH. But it seems most likely that the problem is due to some of that amazing list of meds, several of which alter TBG or alter thyroid hormone metabolism. I do not know their indication, but if possible I would gradually discontinue them one by one , until all are gone, and see what happens to her, and the tests. Keep us posted . L De Groot, MD. ...

They explain hypothyroidism and the lesser known thyroid hormone resistance, and how thyroid disease is connected to fibromyalgia…[but]…nearly alway

"Thyroid hormone resistance" . 10 façons déquilibrer les hormones naturellement. Comment équilibrer les hormones naturellement ? Le mot

A pituitary tumor in a patient with thyroid hormone resistance: a diagnostic dilemma.by Safer JD, Colan SD, Fraser LM, Wondisford FE. MiniManuscript.

View Nf1/Nf1 Tg(Wnt1-cre)11Rth/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA: phenotypes, images, diseases, and references.

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Studies on the autosomal dominant syndrome of thyroid hormone resistance have shown that affected patients have a mutant allele for one of the thyroid hormone receptor (TR) isoforms, TRβ (Refetoff et...

Leey and Cryer (1) nicely discuss a patient with a heterozygous mutation in the THRB gene and review the differential diagnosis. A normal serum TSH value with increased total and free T4 and T3 concentrations should raise suspicion that the patient may not have typical thyrotoxicosis. Family members must be assessed for the mutation once the familial proband has been identified. It is important to identify patients with a T3 receptor mutation so that inappropriate treatments can be avoided. Immunoassays for TSH measure serum TSH concentrations only and do not assess TSH biological activity. In unusual circumstances, immunoreactivity and bioactivity are discordant (2). For example, patients with pituitary or hypothalamic disorders may show a decreased ratio of TSH bioactivity to immunoreactivity. Patients with TSH-secreting pituitary tumors, conversely, may show enhanced TSH bioactivity (2). A mutation in the THRB protein is the most common form of thyroid hormone resistance; however, van Mullem ...

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Definition of hormone resistance. Provided by Stedmans medical dictionary and Drugs.com. Includes medical terms and definitions.

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1NQ0: Thyroid hormone receptor-beta mutations conferring hormone resistance and reduced corepressor release exhibit decreased stability in the N-terminal ligand-binding domain

LCC9 PR mRNA Induction. LCC9 cells were selected for resistance against ICI 182,780, which resulted in cross-resistance to Tam (20). Since LCC9 cells are positive for ER-α, antiestrogen resistant, and estrogen-independent, the PGR mRNA induction values for LCC9 cells shown in Figure 4 simulate an antiestrogen resistant patient response to breast cancer treatment. LCC9 control generated expected results, so the rest of the data shown in Figure 4 for LCC9 cells can be considered reliable. LCC9 cells treated with E2 show a marked increase in PGR mRNA induction, as is expected based upon estrogens ability to induce transcription of PGR. When treated with one of ICI 182,780, LY 294,002, or AG825, LCC9 cells did not show any estrogenic activity or significant PGR mRNA induction. This is expected since none of these drugs are known to have estrogenic effects in breast cancer cells. However, Tam is known to exhibit estrogenic effects in Tam-resistant cell lines such as LCC9. This explains why LCC9 ...

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Fanning SW, Jeselsohn R, Dharmarajan V, Mayne CG, Karimi M, Buchwalter G, Houtman R, Toy W, Fowler CE, Han R, Lainé M, Carlson KE, Martin TA, Nowak J, Nwachukwu JC, Hosfield DJ, Chandarlapaty S, Tajkhorshid E, Nettles KW, Griffin PR, Shen Y, Katzenellenbogen JA, Brown M, Greene GL. The SERM/SERD bazedoxifene disrupts ESR1 helix 12 to overcome acquired hormone resistance in breast cancer cells. Elife. 2018 11 29; 7 ...

Fanning SW, Jeselsohn R, Dharmarajan V, Mayne CG, Karimi M, Buchwalter G, Houtman R, Toy W, Fowler CE, Laine M, Carlson KE, Martin TA, Nowak J, Nwachukwu JC, Hosfield DJ, Chandarlapaty S, Tajkhorshid E, Nettles KW, Griffin PR, Shen Y, Katzenellenbogen JA, Brown M, Greene GL. The SERM/SERD Bazedoxifene Disrupts ESR1 Helix 12 to Overcome Acquired Hormone Resistance in Breast Cancer Cells. eLife. 2018. doi: 10.7554/eLife.37161 ...

Fanning SW, Jeselsohn R, Dharmarajan V, Mayne CG, Karimi M, Buchwalter G, Houtman R, Toy W, Fowler CE, Han R, Lainé M, Carlson KE, Martin TA, Nowak J, Nwachukwu JC, Hosfield DJ, Chandarlapaty S, Tajkhorshid E, Nettles KW, Griffin PR, Shen Y, Katzenellenbogen JA, Brown M, Greene GL. The SERM/SERD bazedoxifene disrupts ESR1 helix 12 to overcome acquired hormone resistance in breast cancer cells. Elife. 2018 11 29; 7 ...

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contain only one segment, and are only used with Mobile IPv6. The return value from this function is the number of bytes required to store the routing header. If the value 0 is returned then either the route header type was not recognized or another error occurred ...

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Query: 45 MSYLTKKEDPMKTSFESSDNKPLPRFTTQYTDIRKQSMDTSAKTESSVNKLYQTSDSSKFSVYSNNKKLDVLYKIGFGSLTDQVYKRAFRKGFEFNLMVVGCSGLGKSTFINSLLMSDFYNTEYLGPSKRIKKTVYIEPTTVILKENDVVLKLCLVDTPGFGDAVDNSACWDPIIEYIDNRFDEHIDNENKVNRLIFPDKRIHACIYFIQPTGHNLKPLDVEFMKRIHEKVNIIPVIGKSDTMTPEECRDFKKNVLNQLTFHKIKIYDFPES---------GAAYSASDNDGEVMDLKKCREKIPFSVIGSNIFIDKNGK----KIRGRRYPWGDVEVENAEHNDFVFLKYMIMRTHLLDLKDVTSQQLYEKYRVLKMSKIAEDSNFNVSDGKDPMMQLEAEKGEQENRIKKMEEEMKQLFEQKAEERTTKLKESEIDLEKRKEHMKVQLETQSKELEEQKAKFDLEKSQWE 1421 MS L K D ++ PL ++ +D+ + S+ + +K SS S + D +GF +L +Q+Y+R R+GFEFNLMVVG SGLGKST +NSL +S+ YN +++GPSKRIKKTVY+E TV+LKEN V L+L L+DTPGFGDAVDNS CW+P+++YID RF++H++ E KVNR D R+H +YFI PTGH LKPLD+EFMKR+H+K N++P++ K+D MT EE RDFKK +LN+L HKI++YDFPES G + +ASD+ + +K+ ++++PF+V+G+N ++ K K+RGR YPWG VEVEN EHNDF+ L+ +++RTH+ DL++ T+ YE YR LK+S IA++S F +DGKDPM Q+E EK + E +++KME EM+ +FE K +E+ KLK+SE+DL++R + M+ QLE Q EL E++ +F+ EK WE Sbjct: 1 ...

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TY - JOUR. T1 - Resistance to thyroid hormone (RTH) syndrome reveals novel determinants regulating interaction of T3 receptor with corepressor. AU - Privalsky, Martin L.. AU - Yoh, Sunnie M.. PY - 2000/1/25. Y1 - 2000/1/25. N2 - Thyroid hormone receptors (T3Rs) both repress and activate gene transcription by interacting with auxiliary factors denoted corepressors and coactivators. Resistance to thyroid hormone (RTH) syndrome in humans is manifested as a failure to respond properly to elevated circulating thyroid hormone. RTH syndrome has been mapped to T3Rβ mutations that alter the transcriptional properties of the receptor, resulting in a dominant negative phenotype. We report here a characterization of a series of RTH mutant T3Rs that exhibit unusual interactions with corepressor. Two mutations in receptor helix 11 (Δ430, Δ432) greatly enhance the ability of the mutant receptors to bind to corepressor. A distinct mutation, V264D, in an omega loop region of the receptor, impairs ...

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Abcam provides specific protocols for Anti-Thyroid Hormone Receptor beta antibody [J52] (ab2744) : Recommended IP& WB protocol with ab2743 and ab2744…

Until recently, Dr. Coates thought that cancer of the thyroid gland was essentially the only disease that could cause elevated thyroid hormone levels in dogs, but there are other elements at play. Learn how you can manage your dogs hyperthyroidism by making some simple changes.

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The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex assemblies. As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.

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Fanning, S.W.; Jeselsohn, R.; Dharmarajan, V.; Mayne, C.G.; Karimi, M.; Buchwalter, G.; Houtman, R.; Toy, W.; Fowler, C.E.; Han, R.; Laine, M.; Carlson, K.E.; Martin, T.A.; Nowak, J.; Nwachukwu, J.C.; Hosfield, D.J.; Chandarlapaty, S.; Tajkhorshid, E.; Nettles, K.W.; Griffin, P.R.; Shen, Y.; Katzenellenbogen, J.A.; Brown, M.; Greene, G.L. (2018) The SERM/SERD bazedoxifene disrupts ESR1 helix 12 to overcome acquired hormone resistance in breast cancer cells. eLife, 7, e37161. (Accompanied by a Related Insight article ...

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Compared with the wild-type mouse (left), the Sox9tm2Crm/Sox9tm2Crm H2afvTg(Wnt1-cre)11Rth/0 skeleton shows obvious craniofacial deformities characterized as a domed skull and short snout. However, no abnormalities are seen in the trunk or limbs ...

An optically compensating film comprising a polymer film having a retardation value Re ( &equals (nx - ny) x d) of 0 to 100 nm and a retardation value Rth (&equals {(nx + ny)/2 - nz} x d) of 70 to 500 nm, and an optically anisotropic lay ...

I dont try to connect two of them, but Ive tried activate one neuron by Exp2Syn controlled by netstim. So it works. I wouldnt like publish this model on ModelDB until it is properly tested. So you can download it from my webpage http://nisms.krinc.ru/rth/izh/izhcur.zip and test it. Ill very appr ...

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Basel, June 20, 2017 - Novartis, the global leader in Ophthalmology, today reported that RTH258 (brolucizumab) 6 mg met the primary and key secondary endpoints in two Phase III studies, HAWK and HARRIER. RTH258 3 mg, evaluated in HAWK, also met these endpoints. These pivotal studies enrolled more than 1,800 patients with neovascular age-related macular degeneration (nAMD) across 400 centers worldwide. The primary and key secondary efficacy endpoints were non-inferiority of RTH258 to aflibercept in mean change in best-corrected visual acuity (BCVA) from baseline to week 48, and average mean change over the period of week 36-48, respectively.[3],[4] Both were met with highly significant p values. RTH258 was generally well tolerated with overall ocular and non-ocular (systemic) adverse event rates comparable to aflibercept.[1],[2]. RTH258 demonstrated long-lasting efficacy versus aflibercept dosed every eight weeks. A majority of patients, 57% (HAWK) and 52% (HARRIER), were maintained exclusively ...

A popular dog food brand has recalled one of their canned food products due to the potential of elevated thyroid hormone levels.. WellPet recalled a limited amount of their 13.2 oz Wellness 95% Beef Topper for Dogs. According to the FDA, the specific products recalled will have a best-by date ranging between February 2, 2019, August 19 and 30, 2019.. The FDAs recall release stated that the three best-by date codes of one recipe have the potential to contain elevated levels of naturally occurring beef thyroid hormone.. Elevated levels of beef thyroid hormone may affect a dogs metabolism and can be associated with anxiousness, increased thirst, urinary output and weight loss, the FDA says.. With prolonged consumption these symptoms may increase in severity and may include vomiting, diarrhea, and rapid difficulty breathing, the release says. The release also noted that the majority of studies showed pets symptoms reversing once the animal stops eating products with elevated thyroid ...

0105] This example illustrates a number of important features of the present invention related to C+ optical films. First, comparing samples 42, 44, 45, and 47 which were prepared by adding Pr2O first and, after all of the Pr2O was consumed, followed by Bz2O then Pr2O, it is observed that Rth increases with increasing DSBz. That is, increasing levels of benzoate increases the absolute magnitude of Rth. Second, the order of addition of anhydrides significantly impacts the magnitude of Rth. For example, sample 41 was prepared by adding 4.5 eq Bz2O first and, after all of the Bz2O was consumed, followed by 2 eq Pr2O, Sample 41 had a DSBz=1.98 and an Rth60 of 363.2 nm. Sample 42 was prepared by adding 1 eq Pr2O first and, after all of the Pr2O was consumed, followed by 5 eq Bz2O then 2 eq Pr2O, Sample 42 had a DSBz=1.61 and an Rth60 of 495.5 nm. That is, even though sample 42 had a lower DSBz versus sample 41, the Rth60 for sample 42 was still significantly larger. Similar behavior can be observed ...

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See how others experience elevated thyroid antibodies. Join the community to connect with others like you and learn about their real-world experiences.

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