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Head and neck squamous cell carcinoma (HNSCC) represents a major health concern worldwide. We applied the matrix-assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS) to analyze paired normal (N) and tumor (T) samples from head and neck squamous cell carcinoma as well as liquid chromatography with tandem mass spectrometry (LC-MS/MS) analysis in HNSCC cell lines to identify tumor-associated biomarkers. Our results showed a number of proteins found to be over-expressed in HNSCC. We identified thymosin beta-4 X-linked (TMSB4X) is one of the most significant candidate biomarkers. Higher TMSB4X expression in the tumor was found by N/T-paired HNSCC samples at both RNA and protein level. Overexpression of TMSB4X was found significantly associated with poor prognosis of overall survival (OS, P = 0.006) and recurrence-free survival (RFS, P = 0.013) in HNSCC patients. Silencing of TMSB4X expression in HNSCC cell line reduced the proliferation and invasion ability in vitro, as well ...
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Fairfax Media reported today that 14 players from the Cronulla Sharks NRL club may be suspended by the Australian Anti-Doping Agency (ASADA) for the alleged use of a substance called thymosin beta-4 (TB-4…
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View Notes - W3OutlineLec7 from BIOL D103 at UC Irvine. • Thymosin-Beta4 Sequesters ATP-actin Have plenty of ATP-actin BUTbut it would be
TB-500 is a synthetic fraction of the protein thymosin beta-4, which is present in virtually all human and animal cells. The main purpose of this peptide is to promote healing. It also promotes creation of new blood and muscle cells. The healing...
TMSL8 is well conserved in many mammalian species. Two isoforms, thymosin beta15a and b, exist at different locations, 1.4Mb apart, on human chromosome X, with 98% identity across the coding sequences ...
References for Abcams Human Thymosin beta 4 peptide (ab42291). Please let us know if you have used this product in your publication
TY - GEN. T1 - Neurotrophic roles of the beta-thymosins in the development and regeneration of the nervous system. AU - Sun, Woong. AU - Kim, Hyun. PY - 2007/9/1. Y1 - 2007/9/1. N2 - Beta-thymosins (Tβs) are polypeptides abundant in the cytosol, nucleus, and extracellular space of many cell types. In the nervous system, the expression of Tβs is regulated during the development of the central nervous system and following neuronal insults in cell-type and brain-region dependent manners, which may be related to the function of Tβs in the growth and regeneration of the nervous system. Supporting such a proposition, overexpression of Tβs in neurons has been shown to modify the axonal branches in vivo and neurite branches in vitro. These neurite-modifying functions have been suggested to be due to the activity of Tβs to bind actin. In addition, we recently observed that Tβs suppressed the apoptotic neuronal death in chick embryos, and these functions might be mediated by the extracellularly ...
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Severe dry eye is a debilitating ocular disease resulting in loss of vision, reduced day-to-day function and significant discomfort. Tear substitutes are an important part of the treatment of all patients, however, even with aggressive us, the corneal(ocular)surface often remains very irregular due to poor surface healing.. The agent being evaluated in this study, Thymosin Beta 4, promotes healing of the corneal surface and has been studied in patients with recalcitrant corneal ulcers and erosions with significant success (Arch Ophthalmol. 2010;128(5):636-638., Ann of the NY Acad of Sci, May, 2010).. The study hypothesis is that Thymosin Beta 4, in its role as a modulator of corneal surface healing, may be able to promote healing of the corneal surface allowing for more conventional modalities to take over and maintain a smooth and regular ocular surface. The investigators hope to be able to demonstrate an improvement in visual acuity, surface healing and a reduction in dry-eye related symptoms. ...
Severe dry eye is a debilitating ocular disease resulting in loss of vision, reduced day-to-day function and significant discomfort. Tear substitutes are an important part of the treatment of all patients, however, even with aggressive us, the corneal(ocular)surface often remains very irregular due to poor surface healing.. The agent being evaluated in this study, Thymosin Beta 4, promotes healing of the corneal surface and has been studied in patients with recalcitrant corneal ulcers and erosions with significant success (Arch Ophthalmol. 2010;128(5):636-638., Ann of the NY Acad of Sci, May, 2010).. The study hypothesis is that Thymosin Beta 4, in its role as a modulator of corneal surface healing, may be able to promote healing of the corneal surface allowing for more conventional modalities to take over and maintain a smooth and regular ocular surface. The investigators hope to be able to demonstrate an improvement in visual acuity, surface healing and a reduction in dry-eye related symptoms. ...
Cardiac failure has a principal underlying aetiology of ischaemic damage arising from vascular insufficiency. Molecules that regulate collateral growth in the ischaemic heart also regulate coronary vasculature formation during embryogenesis. Here we identify thymosin beta4 (Tbeta4) as essential for …
en] A peptide with a sequence identical to rat thymosin beta(Tb)15 was reported to be upregulated in human prostate cancer. However, in this report we provide evidence that TbNB, initially identified in human neuroblastoma, is the only Tb isoform upregulated in human prostate cancer and that the Tb15 sequence is not present herein. In addition, we demonstrate that human TbNB has a higher affinity for actin in comparison to Tb4 and promotes cell migration. In combination, this experimentally validates TbNB as functional homologue of rat Tb15 in the human organism and clarifies the current composition of the human Tb family. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved ...
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Rationale: Thymosin beta 4 (Tβ4) is a 43-amino acid factor encoded by an X-linked gene. Recent studies have suggested that Tβ4 is a key factor in cardiac development, growth, disease, epicardial integrity, and blood vessel formation. Cardiac-specific short hairpin (sh)RNA knockdown of tβ4 has been reported to result in embryonic lethality at E14.5-16.5, with severe cardiac and angiogenic defects. However, this shRNA tβ4-knockdown model did not completely abrogate Tβ4 expression. To completely ablate Tβ4 and to rule out the possibility of off-target effects associated with shRNA gene silencing, further studies of global or cardiac-specific knockouts are critical.. ...
Article by by Carmia Borek, Ph.D. /taken from Life extension/ The promise of repairing sun parched aging skin is alluring, especially if damage control may be attained by applying a substance that is abundant in our body. Thymosin beta 4 (Tb4), a molecule that accelerates wound healing in animals and cultured cells, may be valuable…
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*******www.balancedhealthtoday****/Lymplex.html The transformation of primitive or immature lymphocytes into T-lymphocytes and their proliferation in the lymph nodes is promoted by a thymic hormone called thymosin. Ocassionally the thymus persists and may become cancerous after puberty and and the continued secretion of thymosin and the production of abnormal T-cells may contribute to some autoimmune disorders. Conversely, lack of thymosin may also allow inadequate immunologic surveillance and thymosin has been used experimentally to stimulate T-lymphocyte proliferation to fight lymphoma and other cancers. 4. The spleen: The spleen filters the blood and reacts immunologically to blood-borne antigens. This is both a morphologic (physical) and physiologic process. In addition to large numbers of lymphocytes the spleen contains specialized vascular spaces, a meshwork of reticular cells and fibers, and a rich supply of macrophages which monitor the blood. Connective tissue forms a capsule and
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Thymosin β15 is a small actin-binding protein upregulated in highly metastatic rat prostate cancer cells, relative to low metastatic cells.
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Dhaese S, Jonckheere V, Goethals M, et al. (2007). "Functional and profiling studies prove that prostate cancer upregulated neuroblastoma thymosin beta is the true human homologue of rat thymosin beta15". FEBS Lett. 581 (25): 4809-15. doi:10.1016/j.febslet.2007.09.003. PMID 17888914 ...
TMSB4Y - (untagged)-Human thymosin, beta 4, Y-linked (cDNA clone MGC:26307 IMAGE:4798821), complete cds available for purchase from OriGene - Your Gene Company.
Complete information for TMSB4Y gene (Protein Coding), Thymosin Beta 4, Y-Linked, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
Complete information for TMSB4X gene (Protein Coding), Thymosin Beta 4, X-Linked, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
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Linking the ceramide synthases (CerSs) 4 and 5 with apoptosis, endometrial and colon cancers. The newly designed Amplatzer vascular plug is undergoing clinical trials. SLY2 and SLY12 encode proteins with hydrophobic tails similar to synaptobrevins, integral membrane proteins of synaptic vesicles in higher eucaryotes. This prospective, randomized, single-blinded study examined 70 ASA III patients undergoing elective ambulatory varicose vein surgery. The effects of pharmacological treatment in asymptomatic left ventricular dysfunction Population data of 15 autosomal STR loci in Chinese Han population from Jiangsu Province, Eastern China.. Effects of lamivudine and thymosin alpha1 combination therapy on patients with chronic hepatitis B Costs of occupational asthma and of occupational chronic obstructive pulmonary disease. SAM recognition and conformational switching mechanism in the Bacillus subtilis yitJ S box/SAM-I riboswitch. The neutralizing capacity of these immune plasmas is relatively ...
1. A method is described for separating uterine epithelium that is 80% pure and connective-tissue stroma that is 60% pure. This was used to study the effects of steroid hormones on total and nuclear-protein synthesis in these tissues. 2. Oestradiol-17β given alone produces mitoses in the epithelium but not in the stroma. It stimulated incorporation in vitro of [14C]lysine into total protein, histones and acidic nuclear proteins to a greater extent in epithelium than stroma. Incorporation into acidic nuclear proteins was most markedly stimulated, reaching four to six times the normal value 4h after treatment, and then declining rapidly. This peak was only seen in epithelial preparations. 3. After pretreatment with progesterone, oestradiol-17β has the reverse effect, producing mitoses only in stroma. Progesterone alone had no effect on the amounts or rates of incorporation of [14C]lysine into stromal nuclear proteins, but changes after oestradiol-17β treatment were similar to those seen in ...
REA binding to ER is also mutually competitive with its binding to PTα, whereas PTα binds to neither ER nor SRC-1. Thus, as cellular levels of PTα increase, this protein will increasingly bind up REA and sequester it away from ER. This would allow ER to bind to SRC-1 and result in enhanced transcription. The fact that PTα selectively activates ER transcription is the result, at least in part, of the selectivity of REA binding to ER. Since REA does not bind to other nuclear receptors or repress their transcriptional effectiveness (29), its binding to PTα would be of no consequence to the activity of these receptors. The repressor of ER activity, REA, thus functions as an anticoactivator; PTα, by blocking the binding of REA to ER, is able to selectively enhance ER transcriptional activity and thus functions as an anticoactivator inhibitor. This is schematically illustrated in Fig. 11. While we know the stoichiometry of SRC-1 binding to ER (1 molecule of SRC-1 per ER dimer [9]), we do not yet ...
Human TMSB4X full-length ORF ( NP_066932, 1 a.a. - 44 a.a.) recombinant protein with GST-tag at N-terminal. (H00007114-P02) - Products - Abnova
தைமோசின்கள் (Thymosins) என்பவை பல விலங்குகளின் திசுக்களில் காணப்படும் இயக்குநீர் வகையைச் சேர்ந்த சிறிய புரதங்களாகும். தைமசிலிருந்து முதன்முதலாகப் பிரித்தெடுக்கபட்டதால்[1] தைமோசின்கள் என்ற பெயர் பெற்றாலும், தற்பொழுது இவற்றில் பெரும்பாலானவை பல்வேறு திசுக்களில் உள்ளதாகக் கண்டறியப்பட்டுள்ளது. தைமோசின்கள் பலதரப்பட்ட உயிரியல் செயற்பாடுகளில் ஈடுபட்டுள்ளது[2]. முதன்மையாக, ...
The cyclase-associated protein (CAP) from Dictyostelium discoideum was studied in detail regarding its structure and function relationships. The second part of the thesis describes the characterization of the novel actin-related protein filactin from D. discoideum. CAP homologs are multifunctional proteins: they are involved in signal dependent changes in the actin cytoskeleton, in vesicle transport and cell development. The binding of monomeric actin through the C-terminal domain represents a common feature of all CAPs. From four highly conserved regions in this domain the verprolin homology region of the D. discoideum CAP was analyzed in this work. Loss of this region led to a clear decrease, but not suppression of the actin-sequestering activity. In agreement to these data, stable complexes of the modified CAP-C with G-actin could be identified in chemical crosslinking experiments, and it could be shown that CAP-C is able to dimerize. Considering the high conservation of cyclase-associated ...
Protéin mah pilihan dina nangtukeun ayana di mana téh, ukur bisa kapanggih dina kaayaan aktif atawa bentuk asal dina rentang pH nu heureut sarta dina kaayaan leyuran nu kadar éléktrolitna saeutik, ogé moal kapanggih dina cai sulingan. Protéin nu leungiteun bentuk asalna disebut denatured. Protéin kitu umumna teu mibanda struktur sekundér iwal koil acak. Protéin na bentuk asalna mindeng ogé disebut minangka nilep, folded. salah sahiji papanggihan abad ka-20 nu luar biasa nyaéta yén bentuk asal jeung denatured protéin bisa dibulak-balikkeun ku cara ngatur kalawan ati-ati kaayaan leyuran (misal ku dialisis bahan kimiawi nu ngakibatkeun denaturasi), protéin nu denatured bisa balik deui jadi bentuk asalna. Bahasan ngeunaan kumaha protéin bisa aya dina bentuk asalna mangrupa salah sahiji lapang penting dina ulikan biokimia, disebutna ulikan tilepan protéin. Ngaliwatan rékayasa genetik, para panalungtik bisa ngarobah urutan (ku kituna strukturna ogé), "targeting", karentanan kana ...
Protéin mah pilihan dina nangtukeun ayana di mana téh, ukur bisa kapanggih dina kaayaan aktif atawa bentuk asal dina rentang pH nu heureut sarta dina kaayaan leyuran nu kadar éléktrolitna saeutik, ogé moal kapanggih dina cai sulingan. Protéin nu leungiteun bentuk asalna disebut denatured. Protéin kitu umumna teu mibanda struktur sekundér iwal koil acak. Protéin na bentuk asalna mindeng ogé disebut minangka nilep, folded. salah sahiji papanggihan abad ka-20 nu luar biasa nyaéta yén bentuk asal jeung denatured protéin bisa dibulak-balikkeun ku cara ngatur kalawan ati-ati kaayaan leyuran (misal ku dialisis bahan kimiawi nu ngakibatkeun denaturasi), protéin nu denatured bisa balik deui jadi bentuk asalna. Bahasan ngeunaan kumaha protéin bisa aya dina bentuk asalna mangrupa salah sahiji lapang penting dina ulikan biokimia, disebutna ulikan tilepan protéin. Ngaliwatan rékayasa genetik, para panalungtik bisa ngarobah urutan (ku kituna strukturna ogé), "targeting", karentanan kana ...
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Prot_map - a fast tool to align proteins with genome and reconstruct exon- intron structure has been developed recently and available to run at: http://sun1.softberry.ru/berry.phtml? topic=prot_map&group=programs&subgroup=xmap Prot_map program maps a set of protein sequences onto genomic sequence producing gene structures and the corresponding alignments of coding exons with the similar or identical protein queries. Prot_map uses a genomic sequence and a set of protein sequences as its input parameters. Prot_map reconstructs the gene structure on the base of identical or similar protein instead of a set of unordered alignment fragments that generated the Blast program. The program is very fast, and the produces gene structure similar with the accuracy of slow Genewise program (that practically required knowing the protein genomic location) (Table 1). You can further significantly improve the accuracy of gene reconstruction with Fgenesh+ program by using the results of Prot_map (i.e.a fragment of ...
pep:novel chromosome:VEGA66:1:86526737:86529527:1 gene:OTTMUSG00000048097 transcript:OTTMUST00000123575 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:Ptma description:prothymosin alpha ...
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Il est possible de mesurer le taux de renouvellement protéique (cinétique des protéines) à laide disotopes stables. En théorie, il existe un équilibre entre un capital dacides aminés et un capital de protéines dans lorganisme. Le capital dacides aminés est approvisionné par lalimentation ou la dégradation des protéines dans lorganisme. Les acides aminés quittant ce capital sont utilisés pour la synthèse protéique ou sont dégradés. Les éléments dégradés peuvent être piégés dans lair expiré.. LIMC des personnes âgées indépendantes et en bonne santé peut être normal (IMC : 23-25), mais avec lâge ladiposité augmente et le taux de tissu maigre diminue. Des études portant sur la cinétique des protéines ont montré que le renouvellement protéique par kg de poids corporel est moins rapide chez les personnes âgées que chez les sujets plus jeunes. Cependant, les observations du Dr Morais ont montré que le taux de renouvellement protéique exprimé par kg ...
1992 óta foglalkozom dinamikus lábnyomás méréssel. 2008-ban ebben a témában végzett kutatásaim eredményeképpen PhD fokozatot szereztem.. Tagja vagyok az EUROHIP multicentrikus csípőprotézis vizsgálati csapatnak 2003, annak alapítása óta. Az EUROHIP egy 50 európai ortopédiai osztály részvételével kialakított szervezet, német és angliai irányítással, melynek célja többek között a csípőprotézis beültetések "golden standard"-jának kidolgozása.. A magyar Arthroplasztika regiszternek tagja vagyok annak megalakulása óta. Jelenleg is a regiszter összekötője és a helyi regiszter felügyelője vagyok.. ...
Petro, T M.; Chien, G; and Watson, R R., "Alteration of cell-mediated immunity to listeria monocytogenes in protein-malnourished mice treated with thymosin fraction v." (1982). Subject Strain Bibliography 1982. 4325 ...
This study evaluated the clinical activity of RGN-259 (thymosin β4) in comparison with cyclosporine A (CsA), diquafosol (DQS), and lifitegrast (LFA) in a murine model of dry eye. The model was NOD.B10-H2b mice in a 30-40% humidified environment together with daily scopolamine hydrobromide injections for 10 days. After desiccation stress, all drugs were evaluated after 10 treatment days. RGN-259 increased tear production similar to that in the DQS- and LFA-treated mice while CsA was inactive. RGN-259 improved corneal smoothness and decreased fluorescein staining similar to that of LFA group while CsA and DQS were inactive. Corneal epithelial detachment was reduced by RGN-259, and DQS and LFA showed similar activity but the CsA was inactive. RGN-259 increased conjunctival goblet cells and mucin production comparable to that seen with CsA, while DQS and LFA were inactive. RGN-259 reduced the over-expression of inflammatory factors comparable to that with CsA and LFA, while DQS was inactive. RGN-259
OBJECTIVE The authors previous studies have suggested that thymosin beta 4 (Tβ4), a major actin-sequestering protein, improves functional recovery after neural injury. N-acetyl-seryl-aspartyl-lysyl-proline (AcSDKP) is an active peptide fragment of Tβ4. Its effect as a treatment of traumatic brain injury (TBI) has not been investigated. Thus, this study was designed to determine whether AcSDKP treatment improves functional recovery in rats after TBI. METHODS Young adult male Wistar rats were randomly divided into the following groups: 1) sham group (no injury); 2) TBI + vehicle group (0.01 N acetic acid); and 3) TBI + AcSDKP (0.8 mg/kg/day). TBI was induced by controlled cortical impact over the left parietal cortex. AcSDKP or vehicle was administered subcutaneously starting 1 hour postinjury and continuously for 3 days using an osmotic minipump. Sensorimotor function and spatial learning were assessed using a modified Neurological Severity Score and Morris water maze tests, respectively. Some of the