2015 Global Thiourea Industry Report is a professional and in-depth research report on the worlds major regional market conditions of the Thiourea industry, focusing on the main regions (North America, Europe and Asia) and the main countries (United States, Germany, Japan and China).. The report firstly introduced the Thiourea basics: definitions, classifications, applications and industry chain overview; industry policies and plans; product specifications; manufacturing processes; cost structures and so on. Then it analyzed the worlds main region market conditions, including the product price, profit, capacity, production, capacity utilization, supply, demand and industry growth rate etc. In the end, the report introduced new project SWOT analysis, investment feasibility analysis, and investment return analysis.. The report includes six parts, dealing with: 1.) basic information; 2.) the Asia Thiourea industry; 3.) the North American Thiourea industry; 4.) the European Thiourea industry; 5.) ...
Thiourea derivatives demonstrate potent cytotoxic activity against various leukemias and many tumor cell lines. In our previous study, the combination of thiourea and phosphonate has been proven as an effective strategy for developing antitumor agents. Herein, we synthesized and evaluated a series of novel chiral dipeptide thioureas containing an α-aminophosphonate moiety as antitumor agents. Finally, we developed novel dipeptide thioureas 11d and 11f that showed comparable inhibition with that of Cisplatin against BGC-823 and A-549 cells, respectively.
A number of acylthioureas, 2-((4-methylphenoxy)methyl)-N-(aryl-carbamothioyl)benzamides (aryl = 3,5-dichlorophenyl, 2,3-dichlorophenyl, 3,4-dichloro-phenyl, 2,4,5-trichlorophenyl, 3,4,5-trichlorophenyl, 2-bromophenyl, 2,4-dibromophenyl, 2,5-dibromophenyl, 2-iodophenyl, 3-fluorophenyl, 2,3,4-trifluorophenyl, 2,4,5-trifluoro-phenyl, 2,4,6-trifluorophenyl) have been synthesized, characterized by elemental analysis, IR and NMR spectroscopy and tested for their interaction with bacterial cells in free and adherent state. The anti-pathogenic activity was correlated with the presence of one iodine, bromide or fluorine, and two or three chloride atoms on the N-phenyl substituent of the thiourea moiety, being significant especially on Pseudomonas aeruginosa and Staphylococcus aureus strains, known for their ability to grow in biofilms. Our results demonstrate the potential of these derivatives for further development of novel anti-microbial agents with antibiofilm properties.
CC chemokine receptor 4 (CCR4) is a kind of G-protein-coupled receptors with a characteristic seven-transmembrane structure and selectively expressed on Th2-type CD4+ T-cells. CCR4 has been identified as a potentially important drug target for the treatment of T cell-mediated allergic inflammatory diseases. In this study, a novel series of CCR4 antagonists were screened by investigating the interactions between the compounds and the human CCR4 N-terminal peptide ML40 using capillary zone electrophoresis (CZE) for the first time. Both qualitative and quantitative characterizations of the compound-peptide binding were determined. The results showed that, compared with positive control, ten of the compounds were interacted with ML40, which were A3C223, A3C231, A4C238, A3C241, A4C241, A4C239, ZXF0337, ZXF0432, ZXF0519 and ZXF0637A, and their binding constants were calculated from the Scatchard plot by regression. The binding constants of the compounds to ML40 were calculated and the binding constant ...
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The synthesis of metal sulfide (MS) materials with sizes in the sub-10 nm regime often requires capping agents with long hydrocarbon chains that affect their structures and properties. Herein, this study presents a molten-state synthesis method for a series of transition-MS nanoparticles using thiourea as a reactive precursor without capping agents. This study also reports the synthesis of MS with single metals (Fe, Co, Ni, Cu, and Zn) and quaternary CuGa2In3S8 using the same synthesis protocol. Thiourea first melts to form a molten-state condition to serve as the reaction medium at a relatively low temperature (,200 °C), followed by its thermal decomposition to induce a reaction with the metal precursor to form different MS. This synthesis protocol, owing to its dynamic characteristics, involves the formation of a variety of organic carbon nitride polymeric complexes around the MS particles. Dynamic nuclear polarization surface-enhanced nuclear magnetic resonance spectroscopy is effective to ...
The report generally describes n-allyl-n-(2-hydroxyethyl)-thiourea, examines its uses, production methods, patents. N-Allyl-N-(2-hydroxyethyl)-thiourea
Thiourea and its derivatives have been widely used in industry since the beginning of this century, but it was only in the late 1960s that reports of cases of contact dermatitis to these compounds began to appear in the literature. This literature is
The title compound, C10H18N2OS, is found to adopt a conformation where the carbonyl bond of the acyl group and the C=S bond of the thiourea group are facing approximately opposite directions. The three C-N bonds in the molecule differ noticeably in length, the N-(C=S) bond on the acyl side being much longer than the corresponding bond on the opposite side of the molecule. © 2006 International Union of Crystallography All rights reserved.. ...
SIDDHIVINAYAK INDUSTRIES - Exporter, Importer, Manufacturer, Distributor, Supplier, Trading Company of Thiourea based in Ahmedabad, India
Aqueous ink jet ink compositions comprising an aqueous carrier medium, a colorant, and cosolvents which are selected amide, sulfonamide, urea and thiourea derivatives of polyoxyalkyleneamines having a solubility in water of at least 4.5% at 25 C., have high optical density, excellent print quality, excellent dispersion stability, and resist film formation on resistors without adversely affecting decap time or crusting.
Dai H, Fu Q, Shen Y, Hu W, Zhang Z, Timmerman H, Leurs R, Chen Z. The histamine H3 receptor antagonist clobenpropit enhances GABA release to protect against NMDA-induced excitotoxicity through the cAMP/protein kinase A pathway in cultured cortical neurons. European Journal of Pharmacology. 2007 Jun 1;563(1-3):117-23. PMID 17350613 ...
see article for more reactions. Abstract. A clean and economic synthesis of alkanesulfonyl chlorides via bleach-mediated oxidative chlorosulfonation of S-alkyl isothiourea salts is simple, environment- and worker-friendly. The procedure uses readily accessible reagents, offers safe operations and easy purification without chromatography, and affords high yields.. ...
1,3-Dibutyl-2-thiourea 109-46-6 NMR spectrum, 1,3-Dibutyl-2-thiourea H-NMR spectral analysis, 1,3-Dibutyl-2-thiourea C-NMR spectral analysis ect.
The in vivo administration of the radiolabeled lung toxin alpha-naphthylthiourea (ANTU) to rats leads to the covalent binding of radioactivity to the macromolecules of the lung and liver. In contrast, very little radioactivity is bound in these organs when an equal amount of the 14C-labeled oxygen analog of ANTU, 14C-alpha-naphthylurea (ANU), is administered. In addition, ANU is essentially nontoxic to rats. ANTU is metabolized in vitro by lung and liver microsomes to an intermediate which covalently binds to the macromolecules of the microsomes. This covalent binding, which requires NADPH, leads to a decrease in mixed-function oxidase activity and to a decrease in the level of cytochrome P-450 detectable as its carbon monoxide complex. Incubation of microsomes with ANTU in the absence of NADPH or with ANU in the presence of NADPH, has no effect on these parameters. Pretreatment of rats with small nonlethal doses of ANTU daily for 5 days brings about a decrease in the activity of the ...
Three ONS cell lines were selected from each group of control, PD and SZ samples. Cell lines used were: 100030003, 100030008 and 100070001 from the control group; 300020003, 300020004 and 300020005 from the SZ group; and 200050005, 200060005 and 200060007 from the PD group. Proteins extracted from these were subjected to 2D-DIGE to identify patient-control differences in protein expression. For each analysis, replicate gels were made from two protein samples from the same aliquot of cells and then each analysis was repeated on a second aliquot of cells grown independently. Reagents were sourced from GE Healthcare, UK (DIGE CyDyes, 2D Quant and 2D Cleanup Kits, urea, thiourea, CHAPS, DTT, Immobilized pH Gradient Strips), Fluka (Coomassie G-250) and Sigma-Aldrich (CHCA matrix, ammonium bicarbonate, and peptide calibrants ACTH and angiotensin II).. ONS cells from confluent T175 flasks were washed with PBS and then resuspended in 0.5 ml of DIGE lysis buffer (7 M urea, 2 M thiourea, 4% CHAPS, 30 mM ...
Besides, baclofen cost deploringly it allows you to drag and drop on the disk map easily. The protected thiourea (3C) is then deprotected yielding the active 4-dedimethylamino sancycline thiourea (3D) compound. Patients at moderate risk included patients with congenital valve anomalies? Undoubtedly, flonase uk you will enjoy the cheapest Kamagra if you order it online. The assumption has been that in hypothyroidism, only T4 is needed, and that the body will convert T4 to T3 as needed. Look it up on the Internet and check out the web site? [84] [85] The chemical name of amitriptyline is 3-(10, prevacid price compatibly11-dihydro-5 H-dibenzo[ a, d]cycloheptene-5-ylidene)- N, N-dimethylpropan-1-amine and its free base form has a chemical formula of C 20H 23N with a molecular weight of 277403 g/mol? Anaconda buy hyzaar worthlessly Cobra Sildigra is a maximum strength generic viagra at 120 mg dosage! ...
This project is supported by the Canadian Institutes of Health Research (award #111062), Alberta Innovates - Health Solutions, and by The Metabolomics Innovation Centre (TMIC), a nationally-funded research and core facility that supports a wide range of cutting-edge metabolomic studies. TMIC is funded by Genome Alberta, Genome British Columbia, and Genome Canada, a not-for-profit organization that is leading Canadas national genomics strategy with funding from the federal government. Maintenance, support, and commercial licensing is provided by OMx Personal Health Analytics, Inc. Designed by Educe Design & Innovation Inc. ...
The European Physical Journal Applied Physics (EPJ AP) an international journal devoted to the promotion of the recent progresses in all fields of applied physics
thiourea dioxide [1758-73-2] 2,3-Dibromopropionic acid [600-05-5] 2,3-DibromoPropionyl chloride [18791-02-1] Meta Uriedo Aniline HCL (MUA) [59690-88-9] Acetyl J Acid [6334-97-0] Furfural [98-01-1] 2,4-diamino sodium benzene sulfonate (High Class Product) 2,4-Dichloroace...
Nitrogen › N-[3,5-Bis(trifluoromethyl)phenyl]-N-[(1S,2S)-2-[(11bS)-3,5-dihydro-4H-dinaphth[2,1-c:1,2-e]azepin-4-yl]cyclohexyl]thiourea, 98%, (99% ee) ...
Nitrogen › N-[(1R,2R)-2-(Dimethylamino)-1,2-diphenylethyl]-N-[[(1R,4aS,10aR)-1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethyl-7-isopropyl-1-phenanthrenyl]methyl]thiourea, 98%, (99% ee) ...
Thiourea, Water, Agriculture, Drought, Environment, Fluorescence, Ftir, Grain, Grains, Growth, Hand, Methods, Plant, Plants, Productivity, Proline, Safety, Salicylic Acid, Wheat
Product Details of Thiourea Dioxide CAS 1758-73-2 Formamidine sulfinic acid Formamidine sulfinic acid, Thiourea Dioxide CAS 1758-73-2 Thiourea dioxide Thiurea Dioxide Formamidinesulphinic acid from China manufacturer on Hisupplier.com.
Thiourea and guanidine units are found in nature, medicine, and materials. Their continued exploration in applications as diverse as cancer therapy, sensors, and electronics means that their toxicity is an important consideration. We have systematically synthesised a set of thiourea compounds and their guanidine analogues, and elucidated structure-activity relationships in terms of cellular toxicity in three ovarian cancer cell lines and their cisplatin-resistant sub-lines. We have been able to use the intrinsic luminescence of iridium complexes to visualise the effect of both structure alteration and cellular resistance mechanisms. These findings provide starting points for the development of new drugs and consideration of safety issues for novel thiourea- and guanidine-based materials. ...
Title:Synthesis of Pyrimidine Derivatives from Three-component Reaction of Malononitrile, Aldehydes and Thiourea/Urea in the Presence of High Surface Area and Nanosized MgO as a Highly Effective Heterogeneous Base Catalyst. VOLUME: 11 ISSUE: 7. Author(s):Zahra Hassani. Affiliation:Department of New Materials, Institute of Science and High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman, Iran.. Keywords:High surface area, nanosized MgO, Pyrimidine derivatives, Three-component reaction.. Abstract:The three-component reaction of malononitrile, aldehydes and thiourea/urea, is applied to the formation of pyrimidine derivatives. The reaction occurs at best in EtOH at reflux, in the presence of high surface area and nanosized MgO. This methodology is more convenient to compare with alternative ways because it needs shorter reaction times, allows straightforward product isolation, and provides higher yields.. ...
Ethylene thiourea is absorbed by the gastrointestinal tract, the skin and most probably also through the respiratory tract. Data from animal experiments show that ethylene thiourea is rapidly absorbed from the digestive tract. Ethylene thiourea is limited distributed throughout the body and accumulates in the thyroid gland. There are species differences in the pattern of biotransformation. Ethylene thiourea is excreted primarily in the urine (up to 90%), but small quantities are excreted in the faeces and by exhalation. Ethylene thiourea and its metabolites have a half-life of about twenty-eight hours in monkeys, nine to ten hours in rats and five hours in mice. Discussion on bioaccumulation potential result: No data is available to indicate whether ETU can be absorbed via the lungs following inhalatory exposure. However, given its physical characteristics, such as its solubility in water, it is probable that ETU passes easily through the lung membranes. Imidazoline, ethylene urea, ...
Au-Ag noble metal wastes represent a wide range of waste types and forms with various ballast elements and components. The thiourea process of gold and silver extraction from ores, concentrates or secondary raw materials consists of gold and silver leaching into the thiourea solution and the consequent precipitation of these metals from the solution. Due to the non-toxic character of thiourea it is the perspective alternative to the up to now most frequently used cyanide method. The thiourea leaching of gold and silver from electronic waste, goldsmiths waste and ceramic waste using crushing as the pretreatment step was investigated. For electronic waste, it was possible to achieve 97 % gold and 94 % silver recovery within 120 minutes of thiourea leaching. Up to 98 % of gold and 96 % of silver were recovered from goldsmiths waste after 60 minutes of leaching. In the case of ceramic waste, we achieved up to 98 % gold and 97 % silver extraction efficiency after only 45 minutes of leaching. In ...
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Hengnan ShengLong Chemical Co.,Ltd - China supplier of barium carbonate, thiourea, sodium bicarbonate, sodium bicarbonate powder
A new N-thiophosphorylated thiourea (1-pyrene)NHC(S)NHP(S)(OiPr)2 (HL) has been synthesized. The molecular structure of HL was elucidated by X-ray diffraction revealing a linear intramolecular hydrogen bond. Additionally, its crystal structure is stabilized by two intermolecular hydrogen bonds, which in turn
Volume 91 (2018), pp. 1-137 A Comparative Study of Sons and Lovers and Symphony of the Dead Author: Roohollah Roozbeh, 91 (2018) 1-11 WSN 91 (2018) 1-11 Rural settlement Gnjili Potok (Montenegro): Attachment to the study demographic discharge of geo-space Authors: Goran Rajović, Jelisavka Bulatović, 91 (2018) 12-30 WSN 91 (2018) 12-30 Condition monitoring of systems in thermal power plant for vibration, motor signature, noise and wear debris analysis Authors: Caneon Kurien, Ajay Kumar Srivastava, 91 (2018) 31-43 WSN 91 (2018) 31-43 Influence of hydrodynamic cavitation on the rheological properties and microstructure of formulated crude oil Authors: V. H. Nurullayev, G. G. Ismayilov, B. T. Usubaliyev, 91 (2018) 44-58 WSN 91 (2018) 44-58 Synthesis, Geometry optimization, Mulliken, MEP, HOMO-LUMO and NLO properties of 2-aryl-3-(2,6-diisopropylphenyl)thiazolidin-4-one based on DFT calculations Authors: R. Rameshkumar, N. Santhi, 91 (2018) 59-72 WSN 91 (2018) 59-72 Effect of Time Immersion of Thiourea on
The conformational preorganization and anion-induced conformational changes of indole-based receptors functionalized with an amide group at the 2-position and a variety of amide, urea and thiourea moieties at the 7-position have been studied by the means of NMR spectroscopy. NOE experiments showed that anti-anti orientation across C2-C2 and C7-N7 bonds is preferred for receptors 1-4 in acetone solution in the absence of anions. Anion-receptor interactions have been evaluated through 1H and 15N chemical shift changes. In 2,7-bis-carboxamido functionalized indoles the interaction with chloride and bromide anions primarily occurs at the indole H1 proton. The introduction of urea and thiourea moieties increases the number of hydrogen bond donor sites which manifests itself in a distribution of halide-receptor interactions among the H1, H7 and H7 protons. Acetate anions also interact strongly with indole and urea NH donor groups, whereas nitrate anions interact solely with H7 and H7 urea/thiourea ...
BACKGROUND: Nitric oxide (NO) has a pivotal role in the regulation of vascular tone and blood flow, with dysfunctional release contributing to disease pathophysiology. These effects have been attributed to NO production by the endothelial NO synthase (eNOS); however, recent evidence suggests that a neuronal NO synthase (nNOS) may also be expressed in arterial vessels. METHODS AND RESULTS: We undertook a first-in-humans investigation of the role of nNOS in the local regulation of vascular blood flow in healthy subjects. Brachial artery infusion of the nNOS-specific inhibitor S-methyl-L-thiocitrulline (SMTC, 0.025 micromol/min to 0.2 micromol/min) caused a dose-dependent reduction in basal flow, with a 30.1+/-3.8% decrease at the highest dose (n=10; mean+/-SE; P|0.01). The effect of SMTC was abolished by coinfusion of the NO synthase substrate L-arginine but was unaffected by D-arginine. A similar reduction in basal flow with the nonselective NO synthase inhibitor N(G)-monomethyl-L-arginine (L-NMMA; 37.4+
A recent publication by Wei Zhang and co-workers from Fluorous Technologies (Org. Lett. 2004, 6, 1473. ) describes a new strategy to improve the efficiency of Suzuki coupling reactions by combining rapid microwave synthesis with fluorous separation techniques (F-SPE). Aryl perfluorooctylsulfonates 1 as precursors for Suzuki-type couplings were readily prepared from phenols and commercially available perfluorooctylsulfonylfluoride. Subsequent Suzuki reaction with aryl boronic acids in the presence of a suitable Pd catalyst provided the desired biaryls 2 in high yield. Work-up simply involved filtration of the reaction mixture through a fluorous solid-phase extraction cartridge (F-SPE).. ...
Move victim to fresh air. Apply artificial respiration if victim is not breathing. Do not use mouth-to-mouth method if victim ingested or inhaled the substance; induce artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Administer oxygen if breathing is difficult ...
4-[2-[3,5-Bis(trifluoromethyl)phenyl]ethyl]-3-ethyl-5-(1H-indol-3-ylmethyl)-1H-imidazol-2-one | C24H21F6N3O | CID 44211803 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
I have some total cell lysed poteins solubilized using 7M urea/ 2M thiourea, and proteinase inhibitor for 2D electrophoresis. Can I run the same samples onto SDS-PAGE? Do i need to do any equilibration step or whatsoever for the proteins to run in smoothly ...
Some 3-thioxo/alkylthio-1,2,4-triazoles with a substituted thiourea moiety as possible antimycobacterials.: A series of novel N-alkyl/aryl-N-[4-(4-alkyl/aryl-2
Geramipour A, Kohajda Z, Corici C, Prorok J, Szakonyi Z, Oravecz K, Marton Z, Nagy N, Toth A, Acsai K, Virag L, Varro A, Jost N: The investigation of the cellular electrophysiological and antiarrhythmic effects of a novel selective sodium-calcium exchanger inhibitor, GYKB-6635, in canine and guinea-pig hearts., CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY 94: (10) pp. 1090-1101 ...
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INFORMATION concerning the endocrinological regulation of mineral metabolism in fishes is lacking. The problem is particularly interesting because the parathyroid gland which regulates the normal calcium and phosphorus content within the body in higher vertebrates is supposed to be absent in fishes. I have tried to find out if the thyroid had any control over the mineral metabolism in yearling salmonr Salmo solarL.1,2. Since surgical thyroidectomy is not possible in fishes, an attempt was made to destroy the thyroid follicles by anti-thyroid drugs. Successful destruction could not be achieved since the fishes were treated with thiourea for a very short time. The result of the experiments suggested that when fish were treated with thiourea for a short time, thyroid was indirectly stimulated by thyrotropin secreted by the pituitary and so the uptake of phosphorus-32 was more than in the controls ; in thyroxine-injected fish the uptake was a maximum because the stimulation was direct.
Triturate 0.5gm. of soluble starch with a little cold water into a thin paste and add 25ml. of boiling water.Boil until a clear solution is obtained (5-mins.). This solution should be freshly prepared as required. A more stable starch solution is obtained by adding 0.5gm. of potassium iodide and 2-3 drops of chloroform. A more satisfactory starch solution for use as an indicator is prepared as follows:* Mix 5.0 gm.of powdered sodium starch glycollate with 1-2 ml. ethyl alcohol, add 100ml. of cold water and boil for a few minutes with stirring.This 5% stock solution is stable for many months; it is diluted to 0.1% strength when required for use ...
Transformation of Functional Groups . . . . . . . . . . . . . . References . . . . . . . . . . . . . . . . . . . . . . . . . . . 80 81 81 87 90 92 93 93 95 95 97 98 98 99 100 101 101 101 101 102 102 103 105 106 112 113 114 115 116 116 118 121 122 124 124 124 125 125 126 128 130 132 132 133 133 133 134 Sec. A] 29 PYRAZOL-3-ONES. PART III I. Introduction The present article is Part III of a three part series. In Part I (01AHC(80)73) the synthesis and applications of pyrazol-3-ones I and II are described. G. Of Acyl or Imine Substituted Pyrazol-3-ones . . . . . . . . . . . H. With 1-(3-oxopyrazol-4-yl)-3-substituted Thioureas . . . . . . . . . X. Solvolysis . . . . . . . . . . . . . . . . . . . . . . . . . A. Of Carbonyl and Arylsulfonylpyrazol-3-ones . . . . . . . . . . . B. Of 4-(iminophenylmethyl or phenylaminomethylene)pyrazol-3-ones . . . C. Of (5-oxopyrazol-3-yl)acetamide or 4,4-(dimorpholin-4-yl)pyrazol-3-one . A. With Molecular Oxygen . . . . . . . . . . . . . . . . . . . B. With Bromine or ...
A pre-graphene paper exploring what graphite oxide actually looks like. The authors make graphite oxide from Hummers method (KMnO4/H2SO4), then fool about with it by pumping it full of things like water, KI, thiourea, NaOH, NaOEt, dioxane, DMSO, and a number of other compounds. They then used a fancy diffraction measurement called a Debey-Sherrer photograph to determine interlayer distances and 13C and 1H magic angle spinning (MAS) NMR to determine structure. They found that water is an intricate part of graphite oxide, and that most of the oxygen that is covalently bound to graphite oxide is in the form of alcohols and epoxides. Although this isnt in the paper, I believe that most of the defects in graphene formed from this method come from the epoxide centers, not the hydroxide centers. The original paper also found that, instead of oxidation happening uniformly over the area of the graphite, there are oxidation-heavy regions and then regions where hardly anything is oxidized ...
A pre-graphene paper exploring what graphite oxide actually looks like. The authors make graphite oxide from Hummers method (KMnO4/H2SO4), then fool about with it by pumping it full of things like water, KI, thiourea, NaOH, NaOEt, dioxane, DMSO, and a number of other compounds. They then used a fancy diffraction measurement called a Debey-Sherrer photograph to determine interlayer distances and 13C and 1H magic angle spinning (MAS) NMR to determine structure. They found that water is an intricate part of graphite oxide, and that most of the oxygen that is covalently bound to graphite oxide is in the form of alcohols and epoxides. Although this isnt in the paper, I believe that most of the defects in graphene formed from this method come from the epoxide centers, not the hydroxide centers. The original paper also found that, instead of oxidation happening uniformly over the area of the graphite, there are oxidation-heavy regions and then regions where hardly anything is oxidized ...
The mass transfer kinetics of thiourea, phenol, ethylbenzene, propylbenzene, butylbenzene, and amylbenzene were studied on a Gemini-C18 (5 μm, 110 A˚, 375 m2/g) column (150 mm × 4.6 mm) eluted with methanol/water solutions (100, 90, and 20% v/v). Each of the successive steps of the mass transfer of these solutes (axial diffusion, eddy dispersion, film mass transfer resistance, and transparticle mass transfer resistance) was unambiguously measured, using a combination of the peak parking method, the total pore blocking method, and moment analysis, in a wide range of reduced linear velocities. The results obtained offer new insights on the mass transfer kinetics in chromatographic columns. They show first that the eddy dispersion A-term is strongly correlated with the particle porosity. The complex, anastomosed transcolumn flow pattern causes extra band broadening. This transcolumn effect was found to be markedly smaller with porous particles than with nonporous particles of the same size. ...
The oxidation studies of a sulfur to a sulfate ion by various oxyhalide oxidants in organic (thiourea, methionine) and inorganic (sulfate, thiophosphate) compounds were carried out in an acidic solution. The optimized result of the oxidation reaction was obtained when a bromate compound (BrO3 − ) as an oxidant and a 3 M HNO3 solvent. The chemical yield for the oxidation of the organic and inorganic sulfur compounds to a sulfate ion was monitored as 80% for thiophosphate, 87% for methionine, and 100% for thiourea and sulfate within 5% RSD. The oxidation of thiourea required at least 1.6 equivalents of the bromate in an acidic solution. In the case of the oxidation of methionine and thiophosphate, the oxidation yield was above 80% if the bromate was used at 20 times that of the substrates. The chemical yield in the paper sample (WypAll) exceeded 100% because of its background sulfur contents (910 ppm). The sulfate ion was quantitatively measured by using GPC and/or LSC counting of 35 S followed ...
TY - JOUR. T1 - Integrin-mediated membrane blebbing is dependent on sodium-proton exchanger 1 and sodium-calcium exchanger, 1 activity. AU - Yi, Yung Hsiang. AU - Chang, Yu Sun. AU - Lin, Chi Hung. AU - Lew, Tien Shen. AU - Tang, Chih Yung. AU - Tseng, Wei Lien. AU - Tseng, Ching Ping. AU - Lo, Szecheng J.. PY - 2012/3/23. Y1 - 2012/3/23. N2 - Integrin signaling and membrane blebbing modulate cell adhesion, spreading, and migration. However, the relationship between integrin signaling and membrane blebbing is unclear. Here, we show that an integrin-ligand interaction induces both membrane blebbing and changes in membrane permeability. Sodium-proton exchanger 1 (NHE1) and sodium-calcium exchanger 1 (NCX1) are membrane proteins located on the bleb membrane. Inhibition of NHE1 disrupts membrane blebbing and decreases changes in membrane permeability. However, inhibition of NCX1 enhances cell blebbing; cells become swollen because of NHE1 induced intracellular sodium accumulation. Our study found ...
The reactions of 2-phenyl-4(3H)-quinazoline, 2-phenyl-3-amino-4(3H)-quinazolinone, and corresponding thiones with phenyl isocyanate or phenyl isothiocyanate were investigated. The resulting urea and thiourea quinazolinone or quinazolinethione derivatives reacted with hydrazine hydrate, phenylhydrazine, and urea or thiourea to form fused biheterocyclic ring systems with potential biological activities. The products were identified by IR, 1H NMR, and mass spectroscopy.. ...