TY - JOUR. T1 - The Influence of Thyroxine and Thiouracil on Rats Fed Excess Tyrosine (34572). AU - Boctor, Amal M.. AU - Rogers, Quinton. AU - Harper, A. E.. PY - 1970/1/1. Y1 - 1970/1/1. N2 - Addition of thiouracil to a high tyrosine diet alleviated signs of tyrosine toxicity in the rat, whereas, daily injections of thyroxine aggravated them. Plasma tyrosine concentration and liver tyrosine transaminase activity were high in rats fed a high tyrosine diet; thyroxine administration increased them further, but depressed slightly the activity of liver p-hydroxyphenylpyruvate hydroxylase.. AB - Addition of thiouracil to a high tyrosine diet alleviated signs of tyrosine toxicity in the rat, whereas, daily injections of thyroxine aggravated them. Plasma tyrosine concentration and liver tyrosine transaminase activity were high in rats fed a high tyrosine diet; thyroxine administration increased them further, but depressed slightly the activity of liver p-hydroxyphenylpyruvate hydroxylase.. UR - ...

Casas, C B., Induction of hepatomas by thiouracil in inbred strains of mice. (1963). Subject Strain Bibliography 1963. 199 ...

Concerns over the liberation of indiscriminate electrophilic species during MPO-mediated oxidation of N1-substituted-6-aryl-2-thiouracils were minimized by ensuring a high partition ratio for MPO inactivation and by tethering nucleophilic functional groups in proximity of the thiouracil sulfur. Our medicinal chemistry strategy was also weighted toward the design of compounds in the lower range of lipophilicity (logD , 1.5, topologic polar surface area , 100 Å2) to minimize the potential for oxidative metabolism/bioactivation of the thiouracil motif in human liver.. Apart from peroxidases, enzymatic bioactivation of thioureas and related analogs (e.g., thiones, thiocarbamides, etc.) to electrophilic intermediates by mammalian P450 and/or FMO isoforms can also lead to toxicity (Poulsen et al., 1979; Neal and Halpert, 1982; Decker and Doerge, 1992; Onderwater et al., 1999, 2004; Smith and Crespi, 2002; Henderson et al., 2004; Ji et al., 2007). For instance, the cases of clinical hepatotoxicity ...

6-Methyl-2-thiouracil 56-04-2 NMR spectrum, 6-Methyl-2-thiouracil H-NMR spectral analysis, 6-Methyl-2-thiouracil C-NMR spectral analysis ect.

0120]In another preferred embodiment, SEQ ID NO: 1 and/or poly (I:C) can be modified. Many modified nucleotides (nucleotide analogs) are known and can be used in oligonucleotides. A nucleotide analog is a nucleotide which contains some type of modification to either the base, sugar, or phosphate moieties. Modifications to the base moiety would include natural and synthetic modifications of A, C, G, and T/U as well as different purine or pyrimidine bases, such as uracil-5-yl, hypoxanthin-9-yl (I), and 2-aminoadenin-9-yl. A modified base includes but is not limited to locked nucleic acids (LNA), 5-methylcytosine (5-me-C), 5-hydroxymethyl cytosine, xanthine, hypoxanthine, 2-aminoadenine, 6-methyl and other alkyl derivatives of adenine and guanine, 2-propyl and other alkyl derivatives of adenine and guanine, 2-thiouracil, 2-thiothymine and 2-thiocytosine, 5-halouracil and cytosine, 5-propynyl uracil and cytosine, 6-azo uracil, cytosine and thymine, 5-uracil (pseudouracil), 4-thiouracil, 8-halo, ...

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2002 (English)In: Journal of Radioanalytical and Nuclear Chemistry, ISSN 0236-5731, E-ISSN 1588-2780, Vol. 251, 409-441 p.Article in journal (Refereed) Published ...

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PP-2B inhibition by thioureylenes resulted in a repression of NFAT-dependent gene transcription and thus might influence long-term apoptotic events by limiting the expression of proapoptotic genes (Holtz-Heppelmann et al., 1998). However, NMDA receptor activation, disruption of calcium homeostasis, and PP-2B activation is most probably associated with rapid cell death initiated by proapoptotic Bad proteins (Wang et al., 1999). Thioureylenes inhibited PP-2B-dependent Bad dephosphorylation and the subsequent initiation of the intrinsic pathway of apoptosis (Yang et al., 1995). Thus, caspase-3 activity, cleavage of the cellular caspase-3 substrate PARP, and caspase-3-dependent cell death were inhibited in SK-N-SH cells and organotypic hippocampal slice cultures. These events depended on active PP-2B activation, as demonstrated by coincubation with CsA, a specific PP-2B inhibitor, and included the repression of procaspase-3 processing.. Our results suggest that thioureylenes also attenuate ...

In the present study, we elucidated whether all hTAS2R genes are expressed in gustatory tissue and, hence, whether the entire hTAS2R gene family might serve as taste receptors. Previous studies demonstrated that all functionally analyzed TAS2Rs respond to substances known to taste bitter to humans [hTAS2R4, denatonium benzoate (Chandrashekar et al., 2000); hTAS2R7, strychnine (Sainz et al., 2007); hTAS2R10, strychnine (Bufe et al., 2002); hTAS2R14, picrotoxin (Behrens et al., 2004); hTAS2R16, salicin (Bufe et al., 2002); hTAS2R38, 6-n-propyl-2-thiouracil (Kim et al., 2003; Bufe et al., 2005); hTAS2R43/44, aristolochic acid (Kuhn et al., 2004); hTAS2R47, 6-nitrosaccharin (Pronin et al., 2004); only single compounds listed for each receptor] or aversive to rodents [mouse T2R5, cycloheximide; mouse T2R8, denatonium benzoate (Chandrashekar et al., 2000); rat T2R9, cycloheximide (Bufe et al., 2002)]. These findings support the conclusion that most likely all TAS2Rs are indeed bitter sensors. However, ...

* found in: Adenosine 5-triphosphate, disodium salt, 98%, Uracil, 99%, 6-Methyl-2-thiouracil, 98%, Purine, 98%, Adenosine 5-monophosphate monohydrate, 5..

You may also wish to search for items by Chen. 54 matching references were found. Chen, J.; Chen, Y.; Jiang, Y.; Zhao, Y.F., Determinatioin of the gas-phase proton affinity of N-dipropyloxy-phosphoryl alkyl-alanine by electrospray ionization mass spectrometry with the kinetic method, Chemical J. Chinese Universities, 2003, 24, 459. [all data] Liu, H.; Chen, J.; Jiang, Y.; Zhao, Y.F., Study on the enhancement of proton affinity by N-diisopropyloxy phosphorylation of amino acid in mass spectrometry, Chinese Chem. Lett., 2003, 14, 195. [all data] Chen, J.; Liang, Y.; Ma, P., Determination of extremely-low vapor pressure of five esters by using torsion-effusion method, Huagong Xuebao, 1997, 48, 5, 622. [all data] Li, X.A.; Chen, J.; Bowen, K.H., Photoelectron spectroscopic study of the negative ions of 4-thiouracil and 2,4-dithiouracil, J. Chem. Phys., 2011, 134, 7, 074304, https://doi.org/10.1063/1.3555177 . [all data] Lambert, J.; Chen, J.; Buonaugurio, A.; Bowen, K.H.; Do-Thanh, C.L.; Wang, Y.L.; ...

We have developed a simple, rapid, selective and sensitive method for detecting the antitumour agent cis-diamminedichloroplatinum (II) (cisplatin) (CDDP) and its toxic impurities trans-diamminedichloroplatinum (II) (transplatin) (TDDP) amminetri-chloroplatinat (ATCP) anion using HPLC in one run. By using 4-methyl-2-thiouracil (MTU) as a derivatizing agent, new compounds have been formed from the Pt compounds and separated on a mu-Bondapak C-18 column with isocratic elution and detection at 315 nm. ...

Bilalbegović, Goranka; Maksimović, Aleksandar; Mohaček Grošev, Vlasta (2017) Missing Fe: hydrogenated iron nanoparticles. Monthly Notices of the Royal Astronomical Society: Letters, 466 (1). L14-L18. ISSN 1745-3933 Fabijanić, Ivana; Matković-Čalogović, Dubravka; Pilepić, Viktor; Ivanišević, Irena; Mohaček Grošev, Vlasta; Sanković, Krešimir (2017) New Investigations of the Guanine Trichloro Cuprate (II) Complex: (HGua)2[Cu2Cl6]·2H2O. Journal of Molecular Structure, 1128 . pp. 317-324. ISSN 0022-2860 (In Press) Fabijanić, Ivana; Matković-Čalogović, Dubravka; Pilepić, Viktor; Sanković, Krešimir (2017) Structural and computational analysis of intermolecular interactions in a new 2-thiouracil polymorph. Acta Crystallographica Section C: Crystal Structure Communications, 73 (12). pp. 1078-1086. ISSN 0108-2701 Gebavi, Hrvoje; Mikac, Lara; Marciuš, Marijan; Šikić, Mile; Mohaček Grošev, Vlasta; Janči, Tibor; Vidaček, Sanja; Hasanspahić, Emina; Omanović Miklićanin, Enisa; ...

In this paper the results of the influence of various metabolic inhibitors on dif- ferent periods of the vernalization process in winter wheat are provided. It was found that the initial period of vernalization is very sensitive to respiratory inhibitors such as azide and 2, 4-nitrophenol. In the middle period, the inhibitor of nucleo-acid metabolism such as 2-thiouracil significantly prolongated the process of vernalization. At the third period the protein metabolic inhibitor such as chloromycetin strongly inhibited the vernalization process. Our experiments demonstrated that a remarkable replacement of metabolic patterns is existed in the course of vernalization of winter wheat. The relative metabolic processes during the time of vernalization not only car- ried on different in rate and in action model of inhibitors but also alternatively. There- fore, we assumed that vernalization process of winter wheat may be divided into several periods (sub-processes) with different metabolic patterns. On the

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Chem Sci 2019, advance article. G A Bradshaw, A C Colgan, N P Allen, I Pongener, M B Boland, Y Ortin and E M McGarrigle* - Stereoselective organocatalyzed glycosylations - thiouracil, thioureas and monothiophthalimide act as Brønsted acid catalysts at low loadings. DOI: 10.1039/C8SC02788A Angew Chem Int Ed 2014, 53, 8190-8194. E I Balmond, D Benito-Alifonso, D M Coe, R W Alder, E…

INVOLVED IN lipid transport (inferred); lipoprotein metabolic process (inferred); FOUND IN extracellular region (inferred); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; buspirone

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Atherosclerosis was produced in dogs by feeding them thiouracil and cholesterol. The increments in cholesterol concentration at sites along the length of the aortas of these dogs Avere determined by subtracting from the value for each site the corresponding value obtained from normal dogs. After about 1 month on the experimental regimen the cholesterol increments along the length of the aorta formed a gradient. The increment was greatest in the proximal aorta and progressively less down the length of the aorta. After about 5 months on the regimen, the gradient no longer existed. Instead, the cholesterol increment in the abdominal aorta exceeded that in the thoracic aorta. Albumin is known to enter aortic wall with a gradient of rates that is similar to the gradient of cholesterol increments early in the course of experimental atherosclerosis.. The foregoing facts are consistent with the following theory: In the development of atherosclerosis, intact low-density lipoproteins containing ...

To a Christian Source4/1/12*My dear friends in Christ. Please pray for me for healing from thyroid disease (hypothyroidism), anxiety disorder including lighthea

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It is widely accepted that hyperlipidemia may lead to atherosclerosis, and hyperlipidemia has been identified as an independent risk factor for coronary heart disease and ischemic stroke [14]. Extensive epidemiologic and experimental studies have supported the conception that hyperlipidemia may cause nervous system-related diseases [15, 16]. We evaluated the hyperlipidemia model with reference to the Deepa modeling method (normal rat chow supplemented with 4% cholesterol, 1% cholic acid and 0.5% thiouracil, also called the CCT diet) [9]. In rats that were fed the CCT diet for 1 week, the levels of serum TC, TG and LDL-C increased by 2.40, 1.29 and 1.75 times,(P , 0.05), respectively, and the levels of serum HDL-C decreased by 0.26 times (P , 0.05). Factorial analysis shows that the severity of hyperlipidemia was aggravated with the extension of the CCT diet.. Brain tissue is composed of neurons and glial cells, and this tissue is a significant integration center for body movements, sensations ...

Serum sickness-like reactions (SSLRs) refer to adverse reactions that have symptoms similar to those of serum sickness (type III immune complex hypersensitivity) but in which immune complexes are not found. Agents that have been implicated in serum sickness-like reactions include cefaclor, amoxicillin, sulfonamides, tetracyclines, ciprofloxacin, nonsteroidal anti-inflammatory drugs, barbiturates, carbamazepine, propranolol, thiouracil, and allopurinol. Metabolites of these drugs might bind with tissue proteins inappropriately, eliciting an acute inflammatory response that typically develops 7-14 days after initiation of the offending agent. Acute hepatitis B will sometimes be complicated with this syndrome, often resolving as soon as the jaundice subsides. Serum sickness-like reaction is named for its clinical similarity to serum sickness, in which immune complexes are deposited in the skin, joints, and other organs. True serum sickness, a type III hypersensitivity reaction, results in fever, ...

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ENCODES a protein that exhibits collagen binding (ortholog); collagen fibril binding (ortholog); heparin binding (ortholog); INVOLVED IN cell-cell adhesion (ortholog); cell-matrix adhesion (ortholog); collagen fibril organization (ortholog); ASSOCIATED WITH congenital adrenal hyperplasia (ortholog); Congenital Adrenal Hyperplasia due to 21 Hydroxylase Deficiency (ortholog); Cyanosis (ortholog); FOUND IN extracellular matrix (ortholog); extracellular region (ortholog); extracellular space (ortholog); INTERACTS WITH 6-propyl-2-thiouracil; acrylamide; ammonium chloride

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A condition in infancy or early childhood due to an in-utero deficiency of THYROID HORMONES that can be caused by genetic or environmental factors, such as thyroid dysgenesis or HYPOTHYROIDISM in infants of mothers treated with THIOURACIL during pregnancy. Endemic cretinism is the result of iodine deficiency. Clinical symptoms include severe MENTAL RETARDATION, impaired skeletal development, short stature, and MYXEDEMA ...

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There is provided herein a membrane or film comprising one or more aromatic ionomers covalently crosslinked through aryl-aryl (--Ar--Ar--), aryl-ether-aryl (--Ar--O--Ar--), aryl-sulfide-aryl (--Ar--S--Ar--), aryl-sulfone-aryl bonds, or any combination thereof, wherein said one or more aromatic ionomers further comprises at least one electron withdrawing group adapted to improve oxidant resistance of said membrane or film.

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