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Thioridazine belongs to a group of medicines known as the phenothiazine antipsychotics. It is sometimes referred to as a major tranquilliser. Thioridazine is used to treat schizophrenia and symptoms such as hallucinations, delusions, and hostility. Thioridazine can cause life-threatening irregular heartbeat. You should only take thioridazine if your schizophrenia has not responded to other medications. If you experience any of the following symptoms, call your doctor immediately: fast, irregular, or pounding heartbeat, dizziness, lightheadedness, fainting or seizures. Talk to your doctor about the risks of taking thioridazine. ...
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Thioridazine (Mellaril or Melleril) is a piperidine typical antipsychotic drug belonging to the phenothiazine drug group and was previously widely used in the treatment of schizophrenia and psychosis. The branded product was withdrawn worldwide in 2005 because it caused severe cardiac arrhythmias. However, generic versions are still available in the US. Thioridazine was voluntarily discontinued by its manufacturer, Novartis, worldwide because it caused severe cardiac arrhythmias. Its primary use in medicine was the treatment of schizophrenia. It was also tried with some success as a treatment for various psychiatric symptoms seen in people with dementia, but chronic use of thioridazine and other anti-psychotics in people with dementia is not recommended. For further information see: Phenothiazine Thioridazine prolongs the QTc interval in a dose-dependent manner. It produces significantly less extrapyramidal side effects than most first-generation antipsychotics. Its use, along with the use of ...
EL-DIDAMONY, A. M e MOUSTAFA, M. A. TWO SELECTIVE SPECTROPHOTOMETRY METHODS FOR THE DETERMINATION OF THIORIDAZINE HYDROCHLORIDE IN TABLETS AND IN BIOLOGICAL FLUIDS. J. Chil. Chem. Soc. [online]. 2012, vol.57, n.1, pp.983-988. ISSN 0717-9707. http://dx.doi.org/10.4067/S0717-97072012000100006.. Two simple, rapid and selective spectrophotometric methods have been developed for the analysis of the psychoactive drug thioridazine HCl (TRH) in tablets and in biological fluids. The first method is based on the oxidation of TRH by a known excess of N- bromosuccinimide (NBS), followed by the determination of unreacted oxidants by measuring the decrease in absorbance of two different dyes; amaranth (AM) and methylene blue (MB) at a suitable λmax 520 and 660 nm, respectively. Beer-Lambert plots showed good correlation in the concentration ranges of 0.8-4.8 and 0.8-5.6 µg/ml for AM and MB methods, respectively. The second method is based upon the formation of an ion-pair complexes (1: 1) with the acidic ...
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Thorsing, M, Klitgaard JK, Atilano ML, Skov MN, Kolmos HJ, Filipe SR, Kallipolitis BH. 2013. Thioridazine induces major changes in global gene expression and cell wall composition in methicillin-resistant Staphylococcus aureus USA300. PLoS One. 8:e64518 ...
Learn about the potential side effects of thioridazine. Includes common and rare side effects information for consumers and healthcare professionals.
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The treatment of behavioural abnormalities in dementia is a perennial quandary for neuropsychiatrists. Treatment strategies for these problems are largely governed by testimonial data because few controlled trials exist to guide the way. The situation is quite understandable; controlled studies are difficult to do in light of diagnostic heterogeneity, concomitant medical illnesses, and informed consent issues. Furthermore, there are probably many different neurobiological reasons why patients suffering from a given type of dementia would develop agitation, aggression, and disruptive behaviour. Although there is widespread use of thioridazine for agitation in dementia, the meta-analysis of Kirchner et al would suggest cautious use of this compound in the future. The use of this meta-analysis as a basis for conclusions, however, is problematic because it draws from studies with a diverse mixture of treatment comparisons, diagnostic groups, and rating scales. Surprisingly, thioridazine is superior ...
A drug with a long list of heavy side effects, commonly used to treat sufferers of schizophrenia, also possesses some startlingly potent anti-cancer properties, according to research published Thursday in the medical journal Cell.. The drug, thioridazine, is usually dispensed as a last resort for schizophrenics whose symptoms did not respond to other treatments. Scientists said that after analyzing thousands of different drugs for possible anti-cancer effects, they discovered that thioridazine can be used to selectively target and eradicate cancerous stem cells present in leukemia, along with breast, blood, brain, prostate, ovarian, lung and gastrointestinal cancers, all without the worst side effects of todays most frequently used cancer therapies.. "The unusual aspect of our finding is the way this human-ready drug actually kills cancer stem cells - by changing them into cells that are non-cancerous," Mick Bhatia, the studys principal researcher and scientific director of McMasters Stem ...
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Three new ruthenium(II) complexes 1-3 containing N-alkylphenothiazine molecules were synthesized by reaction of [RuCl(2)(η(6)-p-cymene)](2) with chlorpromazine hydrochloride (1), trifluoperazine dihydrochloride (2) or thioridazine hydrochloride (3). The compounds of the general formula L[RuCl(3)(η(6)-p-cymene)] were characterized by elemental analysis and spectroscopic methods (FT-IR, UV-Vis, (1)H and (13)C NMR). Complex 2 was structurally characterized by single crystal X-ray diffraction. In vitro cytotoxic activity of complexes 1-3 were assayed in four human carcinoma cell lines MCF-7, MDA-MB-453 (breast carcinoma), SW-480 (colon carcinoma) and IM9 (myeloma multiple cells ...
Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctors approval. Fluoxetine can stay in your body for many weeks after your last dose and may interact with many other medications. Before using any medication, tell your doctor or pharmacist if you have taken fluoxetine in the previous 5 weeks. Some products that may interact with this drug include: pimozide, thioridazine, drugs removed from your body by certain liver enzymes including carbamazepine, vinblastine, antiarrhythmics such as propafenone/flecainide, tricyclic antidepressants such as desipramine/imipramine, other drugs that can cause bleeding/bruising including antiplatelet drugs such as clopidogrel, ...
Clozapine and olanzapine behave as weak H3-receptor antagonists in vitro with Ki values around 1 and 50 μM, respectively. Despite these modest apparent affinities, both compounds given orally to mice, nearly doubled steady-statetele-methylhistamine levels in brain, with ED50 values as low as 1 and 3 mg/kg, respectively, an effect comparable to those of potent H3-receptor antagonists. This effect corresponded to an enhancement of histamine turnover rate from 45 to 73 ng/g/h as measured in the case of olanzapine using the pargyline test. Other antipsychotics displaying, such as clozapine and olanzapine, high 5-hydroxytryptamine (5-HT)2A receptor antagonist potency, i.e., risperidone, thioridazine, seroquel, and iloperidone, also enhanced markedlytele-methylhistamine levels. This effect was 1) additive with that of a pure H3-receptor antagonist, ciproxifan, 2) mimicked by a 5-HT2A receptor antagonist, ketanserin, 3) reversed by a 5-HT2A receptor agonist, DOI, 4) not shared by antipsychotics with ...
Do not take Generic Seroquel if you are allergic to Generic Seroquel components.. Be careful with Generic Seroquel if you are pregnant, planning to become pregnant, or are breast-feeding.. Do not take Generic Seroquel if you have dementia-related conditions.. Be careful with Generic Seroquel if you take cimetidine (Tagamet); erythromycin (E-Mycin, E.E.S, Ery-Tab); lorazepam (Ativan); rifabutin (Mycobutin) or rifampin (Rifadin, Rimactane, Rifater); steroids (prednisone and others); thioridazine (Mellaril); antifungal medication such as erythromycin (E-Mycin, E.E.S, Ery-Tab), fluconazole (Diflucan), ketoconazole (Nizoral), itraconazole (Sporanox); medicine for depression or mental illness, such as fluoxetine (Prozac), haloperidol (Haldol), imipramine (Tofranil) or risperidone (Risperdal); medication to treat high blood pressure or a heart condition; seizure medication such as carbamazepine (Tegretol), divalproex (Depakote), phenobarbital (Luminal, Solfoton), phenytoin (Dilantin) or valproate ...
Make sure your doctor knows if you are also using amiodarone (Cordarone®), clonidine (Catapres®, Combipres®), deserpidine (Dureticyl®, Harmonyl®), digoxin (Lanoxin®), epinephrine (Epi-Pen®), fentanyl (Actiq®, Duragesic®), haloperidol (Haldol®), ketanserin (Sufrexal®), lithium (Eskalith®, Lithobid®), reserpine (Ser-ap-es®), thioridazine (Mellaril®), verapamil (Calan®, Covera®, Isoptin®), pain or arthritis medicine (such as aspirin, diclofenac, ibuprofen, Advil®, Aleve®, Motrin®, or Orudis®), or a steroid medicine (such as cortisone, prednisone, Azmacort®, Flonase®, or Medrol ...
Connie K. Ho for RedOrbit.com. A group of researchers from McMaster University have found a new drug that can kill cancer stem cells in humans while avoiding the toxic side effects of other traditional cancer treatments.. Over the past 15 years, researchers have thought that stem cells were the cause of many cancers. Canadian researchers first discovered cancer stem cells in particular types of leukemia in 1997. Since then, cancer stem cells have been found in blood, breast, brain, gastrointestinal, lung, ovarian, and prostate cancer.. "The unusual aspect of our finding is the way this human-ready drug actually kills cancer stem cells; by changing them into cells that are non-cancerous," explained Mick Bhatia, the principal investigator for the study and scientific director of McMasters Stem Cell and Cancer Research Institute in the Michael G. DeGroote School of Medicine, in a prepared statement.. The anti-psychotic drug, thioridazine, showed to have no effect on normal stem cells in the study. ...
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Drug Interaction Comments Antipsychotic agents Potential pharmacodynamic interaction (additive (e.g., phenothiazines) hypotensive effect), especially with large doses of phenothiazines [a] Chlorpromazine Potential pharmacokinetic interaction (decreased propranolol clearance) [a] Thioridazine Potential pharmacokinetic interaction (decreased Concomitant use contraindicated [310] thioridazine metabolism). [310] Possible increased risk of serious, potentially fatal cardiac arrhythmias (e.g., torsades de pointes) [310] Haloperidol Potential pharmacodynamic interactions (hypotension and cardiac arrest) [a] Fluoxetine Potential pharmacokinetic interaction (decreased Caution recommended with concomitant propranolol metabolism); [272,273] complete heart use and in those with impaired block reported [272,273] cardiac conduction [272] Sympathomimetics Potential pharmacodynamic interaction (antagonism of Administer epinephrine with caution; β-adrenergic stimulating effects). [a] Very large decreased pulse ...
It is important that your doctor check your progress at regular visits, to allow changes in your dose and help reduce any side effects. Blood tests may be needed to check for unwanted effects. Do not take fluoxetine with a monoamine oxidase (MAO) inhibitor (eg, isocarboxazid [Marplan®], linezolid [Zyvox®], methylene blue injection, phenelzine [Nardil®], selegiline [Eldepryl®], tranylcypromine [Parnate®]). Do not start taking fluoxetine during the 2 weeks after you stop a MAO inhibitor and wait 5 weeks after stopping fluoxetine before you start taking a MAO inhibitor. If you take them together or do not wait the proper amount of time, you may develop confusion, agitation, restlessness, stomach or intestinal symptoms, a sudden high body temperature, an extremely high blood pressure, or severe convulsions. Do not take thioridazine (Mellaril®) with fluoxetine and wait 5 weeks after stopping fluoxetine before you start taking thioridazine. Do not use pimozide (Orap®) with fluoxetine. Using ...
Two controls were sought for each case. Both were in-patients at the same hospital at the time of death of the case. They were each matched for age, gender and duration of in-patient stay and one was also matched for primary psychiatric diagnosis. The purpose of using two controls was to increase the statistical power of the study. The availability of a control unmatched for psychiatric diagnosis allows the investigation of diagnosis as a risk for sudden death, whereas the availability of a control matched for psychiatric diagnosis is helpful if diagnosis is found to be a significant factor for sudden cardiac death. The use of two types of controls also allows the consistency and robustness of associations with drug therapy to be determined in different models. Controls were identified by searching hospital databases for patients of the same gender who were within 5 years of the age of the case. For cases who had been in hospital less than 5 years, controls were sought from the age- and ...
Use of any drugs or substances within 30 days prior to dosing, known to be strong inhibitors or inducers of cytochrome P450 enzymes (including quinidine, tyramine, ketoconazole, testosterone, quinine, gestodene, metyrapone, phenelzine, doxorubicin, troleandomycin, cyclobenzaprine, erythromycin, cocaine, furafylline, cimetidine, dextromethorphan, etc.) or known to prolong the QT interval (including amiodarone, bepridil chloroquine, chlorpromazine, cisapride, clarithromycin, disopyramide dofetilide, domperidone, droperidol, erythromycin, halofantrine, haloperidol, ibutilide, levomethadyl, mesoridazine, methadone, pentamidine, pimozide, procainamide, quinidine, quinolones, sotalol, sparfloxacin, thioridazine,) or barbiturates, opiates, or phenothiazines ...
Do not use this medicine if you are also using cyclosporine (Gengraf®, Neoral®, Sandimmune®), ritonavir (Norvir®), medicine for depression (such as amitriptyline, nefazodone, nortriptyline, Elavil®, Serzone®), medicine for heart rhythm problems (such as amiodarone, disopyramide, dofetilide, flecainide, propafenone, quinidine, sotalol, Cardioquin®, Cordarone®, Norpace®, Tikosyn®), medicine for infections (such as clarithromycin, erythromycin, itraconazole, ketoconazole, telithromycin, voriconazole, Ery-tab®, Nizoral®, Vfend®), or a phenothiazine medicine (such as chlorpromazine, prochlorperazine, promethazine, thioridazine, Compazine®, Mellaril®, Phenergan®, Thorazine®, Trilafon®). Using these medicines together may cause serious side effects. Check with your doctor right away if you develop any of the following: chest pain, shortness of breath, swelling of your hands, ankles, or feet, or weight gain. These may be symptoms of heart failure. This medicine can cause changes in ...
Do not use this medicine if you are also using cyclosporine (Gengraf®, Neoral®, Sandimmune®), ritonavir (Norvir®), medicine for depression (such as amitriptyline, nefazodone, nortriptyline, Elavil®, Serzone®), medicine for heart rhythm problems (such as amiodarone, disopyramide, dofetilide, flecainide, propafenone, quinidine, sotalol, Cardioquin®, Cordarone®, Norpace®, Tikosyn®), medicine for infections (such as clarithromycin, erythromycin, itraconazole, ketoconazole, telithromycin, voriconazole, Ery-tab®, Nizoral®, Vfend®), or a phenothiazine medicine (such as chlorpromazine, prochlorperazine, promethazine, thioridazine, Compazine®, Mellaril®, Phenergan®, Thorazine®, Trilafon®). Using these medicines together may cause serious side effects. Check with your doctor right away if you develop any of the following: chest pain, shortness of breath, swelling of your hands, ankles, or feet, or weight gain. These may be symptoms of heart failure. This medicine can cause changes in ...
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|p style=text-align: justify;|Drug Uses|br /|Biaxin is used for treating infections caused by certain bacteria.|br /||br /|Do NOT use Biaxin if:|br /|• you are allergic to any ingredient in Biaxin or any other macrolide (eg, erythromycin)|br /|• you are taking cisapride, cyclosporine, dofetilide, eletriptan, ergot alkaloids (eg, ergotamine, dihydroergotamine), H1 antagonists (eg, terfenadine, astemizole), pimozide, QT-prolonging agents (eg, quinidine, sotalol, thioridazine), quinolones (eg, ciprofloxacin), or sumatriptan|br /||br /|Contact your doctor or health care provider right away if any of these apply to you.|br /|Before using Biaxin:|br /|Some medical conditions may interact with Biaxin.|br /||br /|Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:|br /|• if you are pregnant, planning to become pregnant, or are breast-feeding|br /|• if you are taking any prescription or nonprescription medicine, herbal
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Mesoridazine (Serentil) is a piperidine neuroleptic drug belonging to the class of drugs called phenothiazines, used in the treatment of schizophrenia. It is a metabolite of thioridazine. The drugs name is derived from the methylsulfoxy and piperidine functional groups in its chemical structure. It has central antiadrenergic, antidopaminergic, antiserotonergic and weak muscarinic anticholinergic effects. Serious side effects include akathisia, tardive dyskinesia and the potentially fatal neuroleptic malignant syndrome. Mesoridazine was withdrawn from the United States market in 2004 due to dangerous side effects, namely irregular heart beat and QT-prolongation of the electrocardiogram.[1] It currently appears to be unavailable worldwide. ...
Make sure your doctor knows if you are also using arsenic trioxide (Trisenox®), cisapride (Propulsid®), dofetilide (Tikosyn®), medicine for heart rhythm problems (such as amiodarone, disopyramide, procainamide, quinidine, Cardioquin®, Cordarone®, Norpace®, Procanbid®, or Quinaglute®), a phenothiazine medicine (such as prochlorperazine, Compazine®, Mellaril®, Phenergan®, Thorazine®, or Trilafon®), medicine for depression (such as amitriptyline, fluoxetine, nortriptyline, Elavil®, Pamelor®, Prozac®, Sarafem®, or Vivactil®), certain antibiotics (such as erythromycin, levofloxacin, moxifloxacin, sparfloxacin, Avelox®, Levaquin®, or Zagam®), or medicine to treat mental illness (such as haloperidol, mesoridazine, pimozide, prochlorperazine, quetiapine, thioridazine, ziprasidone, Compazine®, Geodon®, Haldol®, Mellaril®, Orap®, Serentil®, or Seroquel ...
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Schizophrenia is believed to be a disorder involving abnormalities in brain chemistry. Patients with schizophrenia have elevated dopamine levels within certain parts of their brain and also altered glutamate levels. The role of glutamate is not well understood, so treatment primarily involves blockade of dopamine receptors. Newer agents also block other receptors including serotonin, but as the pathophysiology of the disease is not fully understood, it is unclear how alteration of other neurotransmitter pathways exert therapeutic effects. Drugs are effective at treating positive symptoms of the disorder, but often are poor at treating the negative symptoms. If negative symptoms do respond to treatment, they typically take longer to correct compared with positive symptoms.. First Generation Antipsychotics (FGAs) such as chlorpromazine, thioridazine, perphenazine, thiothixene, and haloperidol work primarily by blocking dopamine (D2) receptors and also block serotonin (5-Hydroxytryptamine) ...
The incidence of sudden cardiac death in users of atypical anti-psychotics like clozapine, risperidone, quetiapine and olanzapine is almost twice that of individuals who do not take these drugs. Sudden cardiac death is a sudden pulseless condition that is fatal, precipitated by ventricular tachyarrhythmia in the absence of known non-cardiac cause. This risk of sudden cardiac death increases with increased dose of the anti-psychotic medications.. Of late atypical anti-psychotics are being increasingly prescribed and are replacing the older anti-psychotic drugs. The results were obtained from a retrospective cohort trail that involved 93,300 users of anti-psychotic medications and 18300 matched controls. It is useful to note that typical anti-psychotics like haloperidol and thioridazine can also cause increased incidence of sudden cardiac death. One of the explanations provided is that anti-psychotics through blockade of potassium channels increase the prolongation of the cardiac repolarization, ...