Oocyte control of granulosa and theca cell function may be mediated by several growth factors via a local feedback loop(s) between these cell types. This study examined both the role of oocyte-secreted factors on granulosa and thecal cells, cultured independently and in co-culture, and the effect of stem cell factor (SCF); a granulosa cell derived peptide that appears to have multiple roles in follicle development. Granulosa and theca cells were isolated from 2-6 mm healthy follicles of mature porcine ovaries and cultured under serum-free conditions, supplemented with: 100 ng/ml LR3 IGF-1, 10 ng/ml insulin, 100 ng/ml testosterone, 0-10 ng/ml SCF, 1 ng/ml FSH (granulosa), 0.01 ng/ml LH (theca) or 1 ng/ml FSH and 0.01 ng/ml LH (co-culture) and with/without oocyte conditioned medium (OCM) or 5 oocytes. Cells were cultured in 96 well plates for 144 h, after which viable cell numbers were determined. Medium was replaced every 48 h and spent medium analysed for steroids.Oocyte secreted factors were ...
PCOS is a complex and multifactorial disease that is the leading cause of infertility in women. Its development and progression are difficult to understand due to the interconnected nature of the hormonal disturbances present in the syndrome. The diagnosis of PCOS includes amenorrhea, hyperandrogenism, and polycystic ovaries, and women with PCOS frequently exhibit insulin resistance, with or without obesity, and increased LH secretion. In addition, the common features of PCOS may be due to malfunction of the reproductive system at the level of the hypothalamus, pituitary, or gonad, independently or together.. Obese women with PCOS have higher testosterone levels than lean women with PCOS, suggesting an additional compounding effect of insulin in PCOS (29). With hyperinsulinemia, energy storage tissues, such as muscle, fat, and liver, exhibit diminished activation of downstream insulin-signaling components, indicating insulin resistance. In contrast, in obese female mice with hyperinsulinemia, ...
Polycystic ovary syndrome (PCOS) is a common reproductive endocrine disorder characterized by ovarian hyperandrogenism. Theca interna cells isolated from the ovaries of women with PCOS are characterized by increased expression of cytochrome P450 17al
Literature References: Gonadotropic hormone secreted by the anterior pituitary under the regulation of LH-RH, q.v. Together with follicle-stimulating hormone, q.v., is critical to the growth and maturity of ovarian follicles. Stimulates androgen production by ovarian theca cells that is converted to estrogen by granulosa cells. Induces ovalution and the development of the corpus luteum. In males, stimulates production of testosterone by Leydig cells of the testes. Structure is a heterodimer of non-covalently linked a and b subunits; analogous with FSH, TSH and chorionic gonadotropin, q.q.v. Isoln from sheep pituitaries: C. H. Li et al., Endocrinology 27, 803 (1940); eidem, Science 92, 355 (1940); eidem, J. Am. Chem. Soc. 64, 367 (1942). Isoln from pig pituitaries: T. Shedlovsky et al., Science 92, 178 (1940); B. F. Chow et al., Endocrinology 30, 650 (1942). Complete amino acid sequence of ovine LH subunits: H. Papkoff et al., J. Am. Chem. Soc. 93, 1531 (1971); W.-K. Liu et al., J. Biol. Chem. ...
Primary monolayer cultures of bovine theca cells isolated from pooled ovarian follicles (3-10 mm diameter) were used to examine the effects of various granulosa cell-derived substances on basal and luteinizing hormone (LH)-induced androgen and progesterone secretion. After an overnight pretreatment period, cells were incubated with a range of treatments including LH, oestradiol-17β, inhibin, activin and follistatin. Media were collected after 48 h and assessment of androstenedione and progesterone secretion made by radioimmunoassay.. Addition of LH (5-50 ng/ml) to the cells resulted in a dose-dependent stimulation of both androstenedione (2·5-to 3-fold rise; P,0·01) and progesterone (∼ 1·6-fold rise; P,0·001) production. Secretion of androstenedione was also raised (up to 5-fold; P,0·001) by addition of oestradiol-17β (0·3-300 ng/ml), whilst levels of the androgen in the presence of both LH (20 ng/ml) and oestradiol (300 ng/ml) were up to 12-fold higher (P,0·001) than control values. ...
Follicles which have been stimulated to develop progress through primary and secondary stages to become mature tertiary or Graafian follicles, in which a large fluid-filled cavity, the antrum, is surrounded by many layers of granulosa cells. Stromal cells around the follicle differentiate into the theca interna and the theca externa (not apparent in this image). Androgen from cells in the theca interna is processed to estrogen in granulosa cells; the estrogen then enters circulation via blood vessels which form in the theca. The cumulus oophorus, containing the oocyte, seldom appears in random sections such as this. ...
r shell - theca interna - are able to produce estrogen.. inner sheath of the follicle (theca interna) is formed from the interstitial tissue of the cortical layer.In the process of cyclical changes in the ovary after ovulation occurs its transformation into the theca lutein cells.Ability-tech fabrics to produce estrogens confirmed the clinical manifestations associated with estrogen stimulation during tech-kletochkovyh ovarian tumors.This is also confirmed by the fact that in the Tecom found estrogens;the content of estrogen in the theca kletochkovyh tumors above (4,6-7,3 g / g) than granulezokletochkovyh (0.02-0.3 mg / g).However, in general, tumors rarely consist of only one cell type, we can speak only of the predominance of a particular type of cellular structure in the tumor.Therefore, the presence of estrogen in granulezo- or tech-kletochkovyh tumors can not be the ultimate criterion of the cellular structures of the ovary that produce estrogen.According to the ideas of both types of cells ...
This study assessed the effects of 4-nitrophenol (PNP) and 3-methyl-4-nitrophenol (PNMC) on steroidogenesis in the granulosa layers (GLs) and theca layers (TLs) of chicken preovulatory follicles in vitro and in vivo. In the.... Read More ...
Question - CT scan shows small posterior bulges indenting theca and distorting the cord. Meaning?. Ask a Doctor about diagnosis, treatment and medication for Pain in arm, Ask a Neurologist
多囊卵巢綜合症是不確定因素造成的不勻相失調。[18][22][23]有一些證據指出它是一種基因疾病。 這些證據包括病例的家族群集、同卵雙胞胎相比更高的一致性和多囊卵巢綜合症的內分泌和代謝特徵的遺傳性[7][22][23]。. 致病性的基因發生在體染色體顯性遺傳,在女性身上具有高度的基因外顯性但是多變的表現度;這代表小孩有50%的機率從雙親的基因遺傳到誘發致病的異變基因片段,並且,如果女兒接受到異變基因,會出現一定程度上的病徵[23][24][25][26]。 異變基因可能從父母雙方遺傳而來,並且也同時可以遺傳給兒女(可能成為帶原者或是早期脫髮或毛髮過多症狀者) [24][26]。表現型:有一部分患者個疾病表現為卵泡膜(英语:theca of follicle)分泌過多的雄性素 ...
Looking for online definition of theca cells in the Medical Dictionary? theca cells explanation free. What is theca cells? Meaning of theca cells medical term. What does theca cells mean?
After ovulation in mammals, rupture of mature follicles is reorganized into the corpus luteum that secrets progesterone (P4) to stimulate endometrial development. The situation in birds differs considerably. Beyond ovulation the ruptured avian follicle forms a postovulatory follicle (POF) that is not considered analogous to mammalian corpus luteum. The function and regression mechanisms of avian POFs remain poorly understood. Here we investigated the changes in apoptotic and autophagic activities that were involved during POF degradation. Results showed that the structure and secretory function of POF3 manifested the most apparent deterioration during whole processes of regression. A TUENL assay revealed that the granulosa layer maintained longer viability than the theca layer. Importantly, mitochondrial apoptosis and endoplasmic reticulum (ER) stress-associated genes and proteins reached their highest levels in the granulosa cells of POF3. Beclin1 was distributed mainly in theca cells and
After ovulation in mammals, rupture of mature follicles is reorganized into the corpus luteum that secrets progesterone (P4) to stimulate endometrial development. The situation in birds differs considerably. Beyond ovulation the ruptured avian follicle forms a postovulatory follicle (POF) that is not considered analogous to mammalian corpus luteum. The function and regression mechanisms of avian POFs remain poorly understood. Here we investigated the changes in apoptotic and autophagic activities that were involved during POF degradation. Results showed that the structure and secretory function of POF3 manifested the most apparent deterioration during whole processes of regression. A TUENL assay revealed that the granulosa layer maintained longer viability than the theca layer. Importantly, mitochondrial apoptosis and endoplasmic reticulum (ER) stress-associated genes and proteins reached their highest levels in the granulosa cells of POF3. Beclin1 was distributed mainly in theca cells and
Hirsutism can be caused by either an increased level of androgens, the male hormones, or an oversensitivity of hair follicles to androgens. Male hormones such as testosterone stimulate hair growth, increase size and intensify the growth and pigmentation of hair. Other symptoms associated with a high level of male hormones include acne, deepening of the voice, and increased muscle mass. The condition is called hyperandrogenism. Growing evidence implicates high circulating levels of insulin in women for the development of hirsutism. This theory is speculated to be consistent with the observation that obese (and thus presumably insulin resistant hyperinsulinemic) women are at high risk of becoming hirsute. Further, treatments that lower insulin levels will lead to a reduction in hirsutism. It is speculated that insulin, at high enough concentration, stimulates the ovarian theca cells to produce androgens. There may also be an effect of high levels of insulin to activate insulin-like growth factor 1 ...
Researchers at the University of Rochester School of Medicine and Dentistry have uncovered the cell in the ovary that governs the timing of ovulation and plays a major role in fertility. This finding could unlock clues to remedy infertility among people who have altered sleep schedules due to shift work or frequent jet lag, for example.. Michael Sellix, Ph.D., assistant professor of Medicine found that theca cells, which aid the development and release of eggs from the ovary, are important for maintaining a cyclic window of sensitivity to the hormone that incites ovulation, or egg release. Theca cells control the ovarys ability to respond to luteinizing hormone (LH) by ramping up production of the receptor for LH at precisely the right time.. Theca cells use a circadian clock to control the timing of LH receptor production. Circadian rhythms, or biological processes that occur on a 24 hour cycle, exist in nearly all of the cells that make up the human body and can even be found in single celled ...
The ovarian steroids, 17-beta estradiol (E2) and progesterone (P4), are critical for normal uterine function, establishment and maintenance of pregnancy, and mammary gland development. Furthermore, the local effects that are essential for normal ovarian physiology are dependent on the endocrine, paracrine, and autocrine actions of E2, P4, and androgens. In most mammals (including humans and mice), ovarian steroidogenesis occurs according to the two-cell/two-gonadotropin theory. This theory describes how granulosa and theca cells work together to make the ovarian steroids. Theca cells respond to LH signaling by increasing the expression of enzymes necessary for the conversion of cholesterol to androgens, such as androstenedione (A) and testosterone (T). Granulosa cells respond to FSH signaling by increasing the expression of enzymes necessary for the conversion of theca-derived androgens into estrogens (E2 and estrone ...
The ovarian steroids, 17-beta estradiol (E2) and progesterone (P4), are critical for normal uterine function, establishment and maintenance of pregnancy, and mammary gland development. Furthermore, the local effects that are essential for normal ovarian physiology are dependent on the endocrine, paracrine, and autocrine actions of E2, P4, and androgens. In most mammals (including humans and mice), ovarian steroidogenesis occurs according to the two-cell/two-gonadotropin theory. This theory describes how granulosa and theca cells work together to make the ovarian steroids. Theca cells respond to LH signaling by increasing the expression of enzymes necessary for the conversion of cholesterol to androgens, such as androstenedione (A) and testosterone (T). Granulosa cells respond to FSH signaling by increasing the expression of enzymes necessary for the conversion of theca-derived androgens into estrogens (E2 and estrone ...
In women with polycystic ovary syndrome (PCOS), the cardinal physiological abnormality is excessive ovarian androgen production marked by increased seru
Citation: N/A Interpretive Summary: In cattle, normal growth and selection of a single ovulatory follicle is a prerequisite for maturation and release of a viable female gamete (oocyte or egg). In addition, hormones from the ovulatory follicle, and the resulting corpus luteum, prepare the uterus for gamete transport, fertilization and embryonic development. Fertilization rate for the female egametes is above 95%; however, only 70 to 75% of the fertilized gametes result in birth of a calf. An evaluation of steroid, insulin-like growth factors-I and -II (IGF-I and -II) and IGF binding protein concentrations in follicular fluid indicated that androstenedione and estradiol (aromatase enzyme activity) production increased early in the selection of the ovulatory follicle. The wall of the follicle is composed of granulosa and theca cells which contain the steroidogenic enzymes. Theca cells of the ovulatory follicles had increased binding of luteinizing hormone (LH) which hin turn increased ...
Light microscopy of a growing ovarian follicle at the early antral stage of development. The central oocyte (female germ cell) is surrounded by follicular cells separated from the oocyte cytoplasm by a thin coat of special proteins called the zona pellucida which serves to bind sperm during fertilization, and to protect the early embryo if formed. Peripheral layers of flattened cells make up the thecal tissues. Fluid-filled gaps between follicular cells signify the initial stages of antrum formation during folliculogenesis which enlarge to dominate the volume of the follicle as it approaches ovulation. Magnification x500 when printed at 10 cm. - Stock Image C023/9426
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HORMONIIDefinitie: Sunt substante chimice specifice, produse de glandele cu secretie interna (endocrine) care in cantitati foarte mici regleaza a...
Several lines of evidence indicate that retinoids, derivates of vitamin A, affect reproductive function in birds, however, the mechanism of their action in the ovary is still unknown. Therefore, the present study was designed (i) to show whether in the domestic hen 9-cis retinoic acid (9-cis RA), one of the retinoids, influences steroid secretion in vitro by white and yellow chicken ovarian follicles, and (ii) to detect expression of retinoic acid RXR receptor mRNA in these follicles. The white follicles (small: 1-4 mm, medium: 4-6 mm and large 6-8 mm in diameter) and the three largest yellow preovulatory follicles (F3-F1; 25-37 mm) were isolated from the ovary 3 h before ovulation. The granulosa layer was separated from the theca layer in the preovulatory follicles, which were subsequently divided into 4 equal pieces. The isolated whole white follicles or parts of the granulosa or theca layers were incubated for 24 h at 38oC in Eagle's medium in the following 4 groups: control, ovine LH ...
Ovarian follicle is a fluid filled structure that consists of the developing oocyte as well as other cells involved in the menstuation process -Every month one of these primary follices containing a primary oocyte will devleop into a secondary follicle that contains a secondary oocyte. -During stimulation, secondary oocyte is released into the fallopian tubes while the remainder of cells develop into the corpus luteum.. -Other than the oocyte itself, there are two types of cells in the ovarian follicle:. (1) Theca Cell: Regulates Oogenesis and produces sex steroid hormones. (2) Granulosa Cell: FSH stimulates granulosa cells to convert androgens (coming from the thecal cells) to estradiol by aromatase during the follicular phase of the menstrual cycle.. General Process: LH acts on -, Theca cell = Cholesterol -, Androgen -, Travels to Granulosa cell; which with the aid of FSH; Androgen -, Oestrogen.. ...
TY - JOUR. T1 - Steroid production in vitro by granulosa, theca, and luteal cells from goat ovaries. AU - Band, V.. AU - Kharbanda, S. M.. AU - Murugesan, K.. AU - Farooq, A.. PY - 1987/1/1. Y1 - 1987/1/1. UR - http://www.scopus.com/inward/record.url?scp=0023190616&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0023190616&partnerID=8YFLogxK. U2 - 10.1095/biolreprod36.4.799. DO - 10.1095/biolreprod36.4.799. M3 - Article. C2 - 3109512. AN - SCOPUS:0023190616. VL - 36. SP - 799. EP - 806. JO - Biology of Reproduction. JF - Biology of Reproduction. SN - 0006-3363. IS - 4. ER - ...
PROGESTERONE-producing cells in the CORPUS LUTEUM. The large luteal cells derive from the GRANULOSA CELLS. The small luteal cells derive from the THECA CELLS.
Bisphenol S (BPS) is an endocrine-disrupting chemical with multiple potential mechanisms of action, including as an oestrogen receptor agonist. BPS is increasingly used in plastics and thermal receipts as a substitute for bisphenol A, which has been phased out due to concerns about human health implications. The ability of BPS to alter female reproductive function in mammals has not been widely studied, despite the importance of normal hormone signalling for female reproduction. The aim of this study was to investigate how BPS (in a wide range of doses, including very low doses) affects granulosa cell and theca cell steroid hormone production and cell viability in the bovine ...
If the T-I medium can be transported to a microbiology laboratory the same day of inoculation, do not vent the T-I bottle until it arrives in the receiving laboratory. Upon arrival, wipe the rubber stopper with 70% alcohol, insert a venting needle into the T-I bottle, incubate at 35-37°C with ~5% CO2 (or in a candle-jar), and observe daily for turbidity in the liquid phase for up to 7 days ...
Diploporita: †Class Diploporita Lower Ordovician to Lower Devonian about 400,000,000-500,000,000 years ago; theca globular; respiratory structures pairs of pores. Subphylum Crinozoa Both fossil and living forms (Lower Ordovician about 500,000,000 years ago to Recent); with 5-part symmetry; soft parts enclosed in theca, which gives rise to 5…
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Gene expression changes in the preovulatory follicle of animals receiving bGH treatment.The qPCR fold change in expression pattern of selected genes associated
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Barua A, Yoshimura Y, Tamura T. Localization of macrophages in the ovarian follicles during the follicular growth and postovulatory regression in chicken, Gallus domesticus. Poult Sci. 1998 Sep; 77(9):1417-21 ...
Bovine ovary glandular effects on male penis - Testicular Hypoplasia in a Bull Persistently Infected with .... Healthy blood flow is the key to Natural Male Enhancement. Decreased blood flow can be the result of smoking, poor diet, or even just getting older.
As the blood is resorbed, a solid Corpus Luteum is formed by proliferation of granulosa and theca intera cells as well as blood vessels. This remains on the surface of the ovary ...
As the blood is resorbed, a solid Corpus Luteum is formed by proliferation of granulosa and theca intera cells as well as blood vessels. This remains on the surface of the ovary ...
showed a solid noncalcified neoformation, and a brain CAT scan showed a small solid lesion resulting in erosion of the cranial theca both ... swollen of the skin in the left temporal region . On the CT scan of the skull the lesion of about 14x7 mm seems to invade the temporal .... ...
Genomförandet av interna förändringsprojekt ökar i omfattning till följd av globalisering av marknader och ökad konkurrens (Kotter, 2012). Interna förändringsprojekt kan innebära många typer av förändringar såsom nya arbetssätt, ny organisationsstruktur, nya IT system eller nya affärsmodeller. De har alla en sak gemensamt - målsättningen är att nå en beteendeförändring hos de som berörs av projektet. Det centrala för att lyckas i ett förändringsprojekt är att övervinna förändringsmotstånd hos dem som berörs av projektet (Ljung, 2010).Utgångspunkten i vår studie är att interna förändringsprojekt utförs på olika sätt i olika kulturer. Människors beteende påverkas av den inlärda kulturen och av personligheten. Den inlärda kulturen består av flera olika delar. Den nationella kulturen är en väsentlig del av den inlärda kulturen (Hofstede, 2010). Vi har i vår uppsats observerat på vilket sätt nationella kulturer yttrar sig i två förändringsprojekt. ...
Gloria and Laura seem to be doing fine and you appear to be coping with your own rendition of the Tale of Two Cities; well perhaps coping might be a bit of an oversimplification with all you and Stefan have on your plates. As for your ant infestation I can imagine with having children your concern about exposure to toxins has heightened. However as Kay mentioned there are some lower risk alternatives as for example ant baits, which you can buy commercially or have them home made. From what I gather the tricky part is to discover what they like to dine on; so lets hope yours arent picky eaters ...
CONSULTAS, INTERNAÇÕES, HOSPEDAGEM, TRANSPORTE, MEDICAMENTOS, BANHO E TOSA, HOMEOPATIA VETERINÁRIA, RAÇÕES E TUDO PARA O BEM ESTAR DO SEU ANIMAL
Alessandro Montanelli is currently working in Clinical Investigation Laboratory, Humanitas Clinical and Research Center, Rozzano, Milan, Italy. His interna..
Intervention: Each subject in the PCOS group will receive dexamethasone 1 mg orally in the evening and return the next morning for an injection of 25ug of IV recombinant human chorionic gonadotropin. Subjects will the have blood drawn at -0.5, 0, 0.5, and 24 hours after hCG injection for steroid hormone measurements.. Dexamethasone: Each subject in each group will receive 1 mg of oral dexamethasone in the evening and return in the morning for an injection of 25ug of IV recombinant human chorionic gonadotropin. Subjects will also have blood drawn at times -0.5, 0, 0.5, and 24 hours after the injection of r-hCG for measurement of steroid hormones.. recombinant human chorionic gonadotropin (r-hCG): Each subject in each group will receive 1 mg of oral dexamethasone in the evening and return in the morning for an injection of 25ug of IV recombinant human chorionic gonadotropin (r-hCG). Subjects will also have blood drawn at times -0.5, 0, 0.5, and 24 hours after the injection. ...
Inhibin and Activin are important local modulators of theca cell steroidogenesis in the ovary. needed account activation of the Smad2/3 path. Activin reduced the phrase amounts of steroidogenic severe regulatory proteins (Superstar), whereas Superstar phrase was elevated by SB-431542 and inhibin, by itself and in mixture. was untouched. The phrase of coding 17-hydroxylase was untouched by activin but elevated by SB-431542 and inhibin, and when added in mixture the impact was enhanced further. The phrase of 3-hydroxysteroid dehydrogenase (and by phrase of aromatase in the cumulus granulosa cells encircling the oocyte in the preovulatory hair foillicle, hence reducing exposure to these damaging effects of excess testo-sterone and androgens possibly. In rats, androgens not really just can induce follicular atresia (Hillier & Ross 1979, Daniel & Armstrong 1986, Billig for 5?minutes and resuspended in lifestyle mass media (DMEM-F12 with 100?kIU/d penicillin, 01?g/d streptomycin, 3?mmol/d l-glutamine, ...
Inhibin and Activin are important local modulators of theca cell steroidogenesis in the ovary. needed account activation of the Smad2/3 path. Activin reduced the phrase amounts of steroidogenic severe regulatory proteins (Superstar), whereas Superstar phrase was elevated by SB-431542 and inhibin, by itself and in mixture. was untouched. The phrase of coding 17-hydroxylase was untouched by activin but elevated by SB-431542 and inhibin, and when added in mixture the impact was enhanced further. The phrase of 3-hydroxysteroid dehydrogenase (and by phrase of aromatase in the cumulus granulosa cells encircling the oocyte in the preovulatory hair foillicle, hence reducing exposure to these damaging effects of excess testo-sterone and androgens possibly. In rats, androgens not really just can induce follicular atresia (Hillier & Ross 1979, Daniel & Armstrong 1986, Billig for 5?minutes and resuspended in lifestyle mass media (DMEM-F12 with 100?kIU/d penicillin, 01?g/d streptomycin, 3?mmol/d l-glutamine, ...
In cycling rodents, the circulating E and P are produced and secreted by the concerted actions of ovarian granulosa and theca cells (10). The adrenal glands in rodents are incapable of synthesizing significant levels of these steroid hormones (11). In pregnant mice, the corpora lutea develop fully by d 3 of pregnancy and start to produce P, the level of which increases and remains elevated until mid-gestation (12). In contrast, the level of serum E, which is high on d 1 of pregnancy because of the preovulatory hormonal surge, decreases and reaches approximately 15 pg/mL on d 2 and 3. The serum E level increases transiently to approximately 22 pg/mL on d 4 of pregnancy and plays a critical role in embryo attachment. When the embryo attaches to the uterus, the ovarian E synthesis decreases. During the decidualization phase, which lasts from d 5 through 8 of gestation, the circulating level of E remains low at approximately 15 pg/mL (12). When the ovaries were removed after embryo attachment, ...
Organogenesis of the ovary is a highly orchestrated process involving multiple lineage determinations of ovarian surface epithelium, granulosa cells, and theca cells. While the sources of ovarian surface epithelium and ...
Objetivo Comparar os fluxos livres, os calibres e os comprimentos da artéria torácica interna esquerda (ATIE) pediculada (P) e esqueletizada (E) no transoperatório antes e depois da aplicação do vasodilatador tópico (VT). Métodos Em ensaio clínico randomizado e cego foram estudados 50 pacientes submetidos a cirurgia de revascularização miocárdica eletivas quanto ao emprego da ATIE in situ nas formas P ou E. Dos 25 pacientes no grupo pediculada (GP), 16 eram do sexo masculino, apresentando angina classe II e III (NYHA) e fração de ejeção (FE) de 50,8 ± 9,2%. No grupo esqueletizada (GE), 19 pacientes eram do sexo masculino, possuindo angina classe II e FE de 46,8 ± 9,3%. As medidas foram realizadas pré-circulação extracorpórea e divididas em duas fases: fase 1 (antes) e fase 2 (após 15 min da aplicação da papaverina tópica a 2,5 mg/ml a 37ºC). Durante as aferições, eram monitoradas a pressão arterial média, pressão venosa central e freqüência cardíaca. Resultados ...
LONDON and NIJMEGEN and UTRECHT, The Netherlands, September 12, 2011 /PRNewswire/ -- Silence Therapeutics and InteRNA Technologies Sign Collaboration to...