Genetic predisposition to testicular germ-cell tumours Testicular germ-cell tumours (TGCT) are the most common neoplasm in young men. Various studies have suggested the existence of an inherited predisposition to development of these tumours. Genome-wide screens subsequently provided evidence of a TGCT susceptibility gene on chromosome Xq27 (TGCT1) that might also predispose to cryptorchism. However, this putative gene has yet to be identified, and other TGCT susceptibility genes probably exist. Completion of the human gene map and advances in genetic research will facilitate further investigation of genetic predisposition to TGCT. Insight into inheritance of TGCT might lead to the identification of individuals at increased risk of developing the disorder, increase our understanding of the mutation pathways that lead to sporadic cases, and contribute to improvement in diagnosis and treatment. Clinicians should record the family history of cancer and urogenital differentiation defects in patients ...
Treatment of The testicles are located inside the scrotum, a loose bag of skin underneath the penis. They produce male sex hormones and sperm cells for reproduction, Testicular cancer is the most common cancer in American males between the ages of 15 and 34. But denial and embarrassment about the testicles contribute to testicular cancer being one of the least mentioned cancers. The cause of testicular cancer is unknown, Testicular cancer is highly treatable when diagnosed early. Depending on the type and stage of testicular cancer, you may receive one of several treatments, or a combination. Regular testicular self-examinations can help identify dangerous growths early, when the chance for successful treatment of testicular cancer is highest, Testicular Cancer, Testicular Cancer Symptoms, Diagnosis Of Testicular Cancer, Testicular Cancer Diagnosis, Testicular Cancer Risk Factors, Testicular Cancer Treatment, Testicular Cancer Test, Testicular Cancer Surgery, Testicular Cancer Prevention, Testicular
BACKGROUND: Resistance to cisplatin-based chemotherapy is associated with poor prognosis in testicular germ cell cancer, emphasising the need for new therapeutic approaches. In this respect, the therapeutic concept of anti-angiogenesis is of particular interest. In a previous study, we presented two novel anti-angiogenic compounds, HP-2 and HP-14, blocking the tyrosine kinase activity of angiogenic growth factor receptors, such as vascular endothelial growth factor receptor-2 (VEGFR-2), and related signalling pathways in testicular cancer. In this study, we investigated the efficacy of these new compounds in platinum-resistant testicular germ cell tumours (TGCTs), in vitro and in vivo. METHODS AND RESULTS: Drug-induced changes in cell proliferation of the cisplatin-sensitive TGCT cell line 2102EP and its cisplatin-resistant counterpart 2102EP-R, both expressing the VEGFR-2, were evaluated by crystal violet staining. Both compounds inhibited the growth of cisplatin-resistant TGCT cells in a ...
1. Manku G, Hueso A, Brimo F, Chan P, Gonzalez-Peramato P, Jabado N. et al. Changes in the expression profiles of claudins during gonocyte differentiation and in seminomas. Andrology. 2016;4:95-110 2. Das MK, Furu K, Evensen HF, Haugen OP, Haugen TB. Knockdown of SPRY4 and SPRY4-IT1 inhibits cell growth and phosphorylation of Akt in human testicular germ cell tumours. Sci Rep. 2018;8:2462 3. International Prognostic Factors Study G, Lorch A, Beyer J, Bascoul-Mollevi C, Kramar A, Einhorn LH. et al. Prognostic factors in patients with metastatic germ cell tumors who experienced treatment failure with cisplatin-based first-line chemotherapy. J Clin Oncol. 2010;28:4906-11 4. Turnbull C, Rahman N. Genome-wide association studies provide new insights into the genetic basis of testicular germ-cell tumour. Int J Androl. 2011;34:e86-96 discussion e-7 5. Hanna NH, Einhorn LH. Testicular cancer-discoveries and updates. N Engl J Med. 2014;371:2005-16 6. Kanetsky PA, Mitra N, Vardhanabhuti S, Li M, Vaughn ...
TY - JOUR. T1 - Cumulative burden of morbidity among testicular cancer survivors after standard cisplatin-based chemotherapy. T2 - A multi-institutional study. AU - the Platinum Study Group. AU - Kerns, Sarah L.. AU - Fung, Chunkit. AU - Monahan, Patrick O.. AU - Ardeshir-Rouhani-Fard, Shirin. AU - Abu Zaid, Mohammad I.. AU - Williams, Anna Lynn M.. AU - Stump, Timothy E.. AU - Sesso, Howard D.. AU - Feldman, Darren R.. AU - Hamilton, Robert J.. AU - Vaughn, David J.. AU - Beard, Clair. AU - Huddart, Robert A.. AU - Kim, Jeri. AU - Kollmannsberger, Christian. AU - Sahasrabudhe, Deepak M.. AU - Cook, Ryan. AU - Fossa, Sophie D.. AU - Einhorn, Lawrence H.. AU - Travis, Lois B.. N1 - Funding Information: Supported by the National Cancer Institute (1R01 CA157823 to L.B.T. and K07 CA187546 to S.L.K.). Members of the Platinum Study Group are Howard D. Sesso (Brigham and Womens Hospital); Clair Beard and Stephanie Curreri (Dana-Farber Cancer Institute); Lois B. Travis, Lawrence H. Einhorn, Mary ...
Long-term studies have shown that testicular cancer survivors who received radiation and chemotherapy have an increased risk of cardiovascular problems and death compared to the general population, and that chemotherapy for the disease may also pose a higher risk of developing metabolic syndromes. Patients may reduce their chances of developing of these problems by adopting healthy diet and exercise habits, refraining from smoking, and limiting alcohol consumption, but the new study shows that many testicular cancer survivors are, instead, placing themselves at even greater risk.. The team studied 189 patients who were diagnosed with testicular cancer between 1990 and 2007 and recruited through the Pennsylvania Cancer Registry. Patients, who were, on average, 44 years old and 6.8 years post-diagnosis, completed surveys about various health habits. Almost 25 percent of patients surveyed reported current tobacco use, and 35 percent reported risky alcohol use, which the researchers defined as 14 ...
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According to a new study, boys whose testes have not descended into the scrotum at birth, may be nearly three times more likely to develop testicular cancer later in life.. Previous studies of the condition called cryptorchidism (undescended testes) have shown that in 5 to 10 percent of testicular cancer patients undescended testes were present.. However, it has remained unclear exactly how much a boys risk of testicular cancer is increased if he was born with undescended testes.. The new study was designed to answer that question and concluded that boys with undescended testes were 2.9 times more likely to develop testicular cancer. About 6 percent of newborn boys are born with undescended testes.. Researchers must now consider whether this degree of increased cancer risk means that boys born with the condition should undergo heightened surveillance for testicular cancer in addition to current close followup.. The study was published in the journal Archives of Disease in Childhood.. ...
Many testicular cancer survivors experience hearing loss after cisplatin-based chemotherapy, according to researchers at Indiana University.
Testicular germ cell tumors (TGCT) are the most commonly diagnosed neoplasm of young men 15-45 years of age, and incidence of these tumors has been increasing in recent decades for reasons currently unknown. Histologic type of TGCT can be divided into the broad categories of seminomas and non-seminomas. It currently remains to be elucidated if these histologic types share a common etiology. In this study we analyzed the largest set of bilateral cases of TGCT ever assembled, 550, to determine if the histologic type of the first tumor predicts that of the second. Presuming an individual with a history of two primary tumors has the same risk factors for both tumors, a concordance of histologic types in the same individual would suggest that the risk factors for seminomas and non-seminomas differ. The data show no association between the histologic type of the first and second tumors when the analysis is adjusted for the age at first diagnosis (odds ratio (OR)=0.95) This finding suggests that the ...
Multi-institutional assessment of adverse health outcomes among north American testicular cancer survivors after modern cisplatin-based chemotherapy Academic Article ...
Chromosomal imbalances associated with carcinoma in situ and associated testicular germ cell tumours of adolescents and adults. Carcinoma in situ (CIS) or intratubular germ cell neoplasia is generally considered the precursor lesion of adult testicular germ cell tumours (TGCT). The chromosomal imbalances associated with CIS and the corresponding seminoma (SE) or nonseminoma (NS) have been determined by comparative genomic hybridization (CGH) analysis of microdissected material from seven cases. Significantly, the CIS showed no gain of 12p material whereas in the invasive components of all cases gain of 12p was found, in 2 cases associated with amplification of the 12p11.2-12.1 region. Interphase fluorescence in situ analysis was consistent with this and provided evidence for the i(12p) or 12p11.2-12.1 amplification in the SE and NS but not in the corresponding CIS. This suggests a role for these changes in progression of CIS to invasive testicular cancer or progression of the invasive disease. ...
Genome-wide epigenetic modification plays a crucial role in regulating genome functions at critical stages of development. In particular, DNA methylation is known to be reprogrammed on a genome-wide level in germ cells and in preimplantation embryos, although it is relatively stable in somatic cells …
A testicular neoplasm is a type of abnormal growth in the testicle. The main signs of a testicular neoplasm are a painless lump...
A 18 year old man presented with a left sided testicular and left sided abdominal mass on routine physical examination. There was evidence of liver and lung metastases on workup, and tumor markers (HCG, AFP, LDH) were markedly elevated in the thousands. A left ureteral stent was placed for left sided hydronephrosis. He underwent a left radical orchiectomy through a groin incision. Pathological diagnosis was non-seminomatous germ cell tumor containing yolk sac, embryonal and immature teratomatous elements. He underwent four cycles of BEP (bleomycin, etoposide, cis-platin) over a four month period. The tumor markers returned to normal and the liver and lung metastases disappeared. The abdominal tumor shrank to 2/3 its original size ...
Dec 08, Testicular Cancer: Sex After Chemotherapy and Radiation. Following chemotherapy, most men experience loss of sexual desire and the ability to . Jun 09, The most common cancer seen in testicular cancer survivors is a second testicular cancer. Compared with most men in the general population, testicular cancer survivors are up to twice as likely to develop a new cancer outside the testicle. The chance of a second cancer changes over time and depends on which treatments were used and how old the. Feb 12, Learn more in ??Second Cancers After Testicular Cancer. Getting emotional support. Some amount of feeling depressed, anxious, or worried is normal when cancer is a part of your life. Some people are affected more than others. But everyone can benefit from help and support from other people, whether friends and family, religious groups ...
Testicular germ cell tumors (TGCTs) are a cancer pharmacology success story with a majority of patients cured even in the highly advanced and metastatic setting. Successful treatment of TGCTs is primarily due to the exquisite responsiveness of this solid tumor to cisplatin-based therapy.
Clinical stage I testicular germ cell tumours (TGCT) are highly curable neoplasms. The treatment of stage I testicular cancer is complex and requires a multidisciplinary approach. Standard options after radical orchiectomy for seminoma include active surveillance, radiation therapy or 1-2 cycles of carboplatin, and options for nonseminoma include active surveillance, retroperitoneal lymph node dissection (RPLND) or 1-2 cycles of bleomycin plus etoposide plus cisplatin (BEP). All the options should be discussed with each patient and treatment choices should be made by shared decision making as virtually all patients with clinical stage I TGCT can be cured of their disease ...
Incidence and survival for testicular germ cell tumor in young males: A report from the Northern Region Young Persons Malignant Disease Registry, United ...
Clinical trial for Testicular Cancer | testicular tumor | tumor testis | Malignant neoplasm of testis , Swiss Austrian German Testicular Cancer Cohort Study - SAG TCCS
Charles C Chung, Peter A Kanetsky, Zhaoming Wang, Michelle A T Hildebrandt, Roelof Koster, Rolf I Skotheim, Christian P Kratz, Clare Turnbull, Victoria K Cortessis, Anne C Bakken, D Timothy Bishop, Michael B Cook, R Loren Erickson, Sophie D Fosså, Kevin B Jacobs, Larissa A Korde, Sigrid M Kraggerud, Ragnhild A Lothe, Jennifer T Loud, Nazneen Rahman, Eila C Skinner, Duncan C Thomas, Xifeng Wu, Meredith Yeager, Fredrick R Schumacher, Mark H Greene, Stephen M Schwartz, Katherine A McGlynn, Stephen J Chanock, Katherine L Nathanson, Meta-analysis identifies four new loci associated with testicular germ cell tumor, Nature Genetics, 2013, 45, 6, ...
Testicular cancer (TC) is the most frequent solid malignancy in young men aged between 15 and 40 years. The worldwide incidence is about 7.5 per 100,000 subjects, but the rates vary considerably between countries and ethnic groups. About 95% of all TCs are represented by testicular germ cell tumors (TGCTs), which include seminoma and non-seminoma histological types. It has been reported that about 18,000 European subjects over reproductive age develop a TGCT every year and its incidence is increasing in several countries over the past 50 years. Early diagnosis and modern treatment have resulted in over 95% survival rate and improved quality of life in testicular cancer survivors. However, the benefits of cancer treatments may hide some risks. In fact, possible side effects can be developed during the treatment itself or later from months to years after the completion of therapy, persisting during the whole life. Therefore, TGCT survivors frequently complain a number of healthy problems such as
TY - JOUR. T1 - ACR Appropriateness Criteria Staging of Testicular Malignancy. AU - Yacoub, Joseph H.. AU - Oto, Aytekin. AU - Allen, Brian C.. AU - Coakley, Fergus. AU - Friedman, Barak. AU - Hartman, Matthew S.. AU - Hosseinzadeh, Keyanoosh. AU - Porter, Christopher. AU - Sahni, V. Anik. AU - Sudakoff, Gary S.. AU - Verma, Sadhna. AU - Wang, Carolyn L.. AU - Remer, Erick M.. AU - Eberhardt, Steven C.. PY - 2016/10/1. Y1 - 2016/10/1. N2 - Testicular cancer represents only 1% of all malignancies occurring in men. However, it is the most frequent malignancy in men between the ages of 20 and 34 years, accounting for 10% to 14% of cancer incidence in that age group. In most instances, the diagnosis of testicular tumors is established with a carefully performed physical examination and scrotal ultrasonography. Tumor markers are useful for determining the presence of residual disease. Cross-sectional imaging studies (CT, MRI) are useful in determining the location of metastases. Chest radiography and ...
The incidence of testis cancer has increased by 40% in the last four decades particularly in men younger than 35 years, a patient population that is at the peak of their reproductive age which prompts many doctors to consider organ-sparing options.. Patient assessment for organ-sparing in testis cancer is crucial, and patient and history taking is very important not only in the diagnosis of testis cancer, but also in patient selection for an organ-sparing option (OSS), said Z. Kopa (HU) in an update lecture on testis cancer during the 15th Central European Meeting held in Budapest.. There are strong arguments for organ-sparing such as the high accuracy in frozen section examination (FSE) which is around 100%, and the increasing attention paid to the cosmetic, functional, and psychological outcomes of patients with testicular tumours, added Kopa, although he noted that the literature lacks studies with a high level of evidence in comparing OSS with radical surgery.. He also cited the EAU ...
There are approximately 8,800 new diagnosis of testis cancer each year, which account for 0.5% of all new cancer diagnoses. Most testis tumors present with a painless mass or swelling in the testis. The patients exam typically reveals a firm, nontender testis mass. Men between 20 and 34 years of age are at highest risk of testis cancer, with decreasing risk over time.. An abnormal testicular exam will trigger a full workup including tumor markers (HCG, AFP, B-HCG), testicular ultrasound and cross-sectional imaging (CT or MRI) to evaluate for metastatic disease. Unless bulky metastatic disease is seen, the patient will need to undergo radical orchiectomy. During this procedure, the affected testis will be removed through an incision in the groin as to not violate or disturb the lymphatic channels in the scrotum. The pathologist will evaluate for the type of tumor cells present which, in conjunction with postoperative tumor marker levels, will determine further therapy.. Testis cancers are ...
TY - JOUR. T1 - Bilateral testicular tumors in an infant. AU - Luo, C. C.. AU - Lin, J. N.. AU - Huang, C. S.. PY - 1998/1. Y1 - 1998/1. N2 - A 7-month-old infant showed bilateral enlarged, non-tender scrotal masses. The level of α-fetoprotein was greater than 10,000 ng/ml preoperatively; a high left inguinal orchiectomy was performed for a suspected yolk-sac tumor. The right testis was diagnosed as a mature teratoma because it was not possible to establish a line of cleavage between the tumor and the normal tissue, and a high right inguinal orchiectomy was performed. Only one case of bilateral testicular teratomas has been reported in the literature to date. We report a rare second case of bilateral testicular tumors, one a yolk-sac turner and the other a teratoma.. AB - A 7-month-old infant showed bilateral enlarged, non-tender scrotal masses. The level of α-fetoprotein was greater than 10,000 ng/ml preoperatively; a high left inguinal orchiectomy was performed for a suspected yolk-sac ...
April is Testicular Cancer Awareness Month. (Washington, DC) -Testicular Cancer is the most common cancer among males age 15-35. Yet, testicular cancer has one of the highest survival rates if found early. With this in mind, Mens Health Network (MHN) encourages boys and men to perform monthly testicular self exams (TSE).. Furthermore, in recognition of Testicular Cancer Awareness Month, MHN is rolling out a unique campaign called Save the Doodads, www.savethedoodads.org, to raise awareness of testicular cancer and the importance of testicular self-examinations. MHN is proud to collaborate with the Doodad Crew at East Tennessee State Universitys College of Public Health on a variety of campus-wide special events and health promotion activites regarding testicular cancer and overall mens health.. Testicular cancer is a very serious but very treatable cancer, said Brandon Leonard, Director of Strategic Initiatives at Mens Health Network. The key is reaching younger men who often dont ...
Abstract:. Metastatic germ cell tumors represent a model of a curable malignant disease due to a unique chemosensitivity to cisplatin-based combination therapy resulting in long term survival rates of about 80%. Therefore, germ cell tumors became a model for the evaluation of long-term treatment toxicity as well as for the role of chemotherapy dose intensification in patients with very advanced disease. Patients with first relapse seem to profit most from high-dose chemotherapy with autologous stem cell support and a multinational study is underway to prove its role. In addition chemotherapy-resistance has become an important area of experimental and clinical research in the few multiply relapsed / refractory patients. Several new agents have been tested in this situation with gemcitabine, paclitaxel and oxaliplatin being the most active. Carefully conducted clinical studies and the development of clinical risk models for all stages of this disease have significantly contributed to the progress ...
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The most common solid tumor in males ages 20-39 is testicular cancer. Testicular cancer is highly curable with 5-year survival rates above 96%. Long-term effects of both the testicular cancer and its treatment are important in understanding survivorship in this population. Chemotherapy poses its own specific risks such as vascular toxicity, lung disease and renal dysfunction. Also important is the understanding of fertility after testicular cancer and even prior to a cancer diagnosis patients may face issues with sperm count and testosterone level abnormalities. It is also critical to be aware of the possibility of developing a second malignancy after testicular cancer with the contralateral testis being a high-risk occurrence.. Source: Hayes-Lattin B, Nichols C. Testicular Cancer: A Prototypic Tumor of Young Adults. Semin Oncol. 2009; 36:432-438. ...
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Testicular cancer is the most common solid tumor among males 15 to 34 years of age, with an estimated 8,850 new cases and 410 deaths during 2017 in the United States. With effective treatment, the overall five-year survival rate is 97%. Risk factors for testicular cancer include undescended testis (cryptorchidism), personal or family history of testicular cancer, age, ethnicity, and infertility. The U.S. Preventive Services Task Force recommends against routine screening in asymptomatic men. Men with symptoms should receive a complete history and physical examination. Scrotal ultrasonography is the preferred initial imaging study. If a solid intratesticular mass is discovered, orchiectomy is both diagnostic and therapeutic. Staging through chest radiography, chemistry panel, liver function tests, and tumor markers guides treatment. Active surveillance, chemotherapy, retroperitoneal lymph node dissection, and radiation therapy are treatment options following orchiectomy. For patients desiring future
ABOUT 1000 of testicular germ-cell tumours occur in men treated for maldescended testes (Whitaker, 1970). The risk of testicular tumour in men with maldescended testes has been estimated at 35 times that of normal men (Whitaker, 1970). Recently 2 case-control studies confirmed the increased risk of testicular tumour in maldescended testes (Morrison, 1976; Henderson et al., 1979). Testicular germ-cell (TGC) tumours may be preceded by carcinoma in situ in a biopsy several years before (Skakkebaek, 1972, 1978). Raised concentrations of serum o-foetoprotein (AFP) and serum human chorionic gonadotropin : subunit (hCG) often preceded other signs of relapse in nonseminomatous TGC tumours (Waldmann & McIntire, 1974). Serum AFP and serum hCG were measured as a screen for TGC tumours in men with maldescended testes, in addition to physical examination and testicular biopsy. The histological findings of the first 50 men biopsied have recently been reported elsewhere (Krabbe et al., 1979). In this paper we report
We ran out of time. These are important(!), so read on…. *Change in survival rates which I could not quite recall in relation to the chemo I used:. 1) Testicular cancer used to be a brutal killer. If you were diagnosed with nonseminoma, you had to have a complete Retroperitoneal Lymph Node Dissection ( Yes, I still had one of these) because it was the only thing that could possibly cure the cancer. If you had Stage III testicular cancer, little could be done. Back in 1970, about 90% of testicular cancer patients died of their disease.. The 70′s brought us the success of Cisplatin which, when used in combination with other chemotherapy drugs and the appropriate use of surgery, brought the cure rate to an astounding 80%! This chemotherapy is not pleasant, but its profound success has allowed the doctors to decrease the toxicity of all of the various testicular cancer treatments. (1). 2) I wanted to mention more about screening and prevention:. There is no standard or routine screening test ...
Recent studies have revealed that testicular cancer is more common in men whove had an undescended testicle as a child and have a higher chance of getting testicular cancer; however it is treatable by surgery. Cancer in the testicles is called testicular cancer, which is part of the male reproductive system. It may be hereditary. People who suffer from infertility are at a major risk. After being treated for testicular cancer in one testis there is a risk of the other being affected, precautions must be taken after the first treatment is over and regular checkups is a must. Men who are taller have a higher risk of testicular cancer for some unknown reason. People who suffer with HIV or AIDS have a risk of developing testicular cancer. ...
Testicular germ cell cancer (GCC) represents 1 % of all human cancers and its incidence has increased by 1 % over the last 50 years [1, 2]. In young men, it represents one of the most malignant forms and is the second commonest cause of cancer-related death [1, 2]. Testicular tumor cell growth constitutes the majority of testicular malignancies [2]. GCC patients have a high cure rate, and are sensitive to radiation and chemotherapy, but 5 % of patients develop resistance to treatment.. Impaired muscle function and cancer-related fatigue (CRF) are two of the most common complications among patients in additiounder chemotherapy [3]. Moreover, early, localized muscular fatigue and severe deconditioning are common observations in clinical practice involving GCC patients undergoing chemotherapy [4]. The cause of this muscle deconditioning is unknown and although the effects of antineoplastic drugs have been described in some detail [4, 5], the way these effects may affect the phenomenon of CRF is ...
In 2015, it is estimated that 8400 U.S. men were diagnosed with testis cancer and 380 men died from testis cancer. Testis cancer is most commonly...
The Testicular Cancer Information, Resource and Support Center. Developed to help patients with testicular cancer and their family members.
Niket Desai was at Google headquarters presenting a new project before a large audience when his phone began vibrating in his pocket. It was his doctor calling to tell him he had testicular cancer.
Risk factors for testicular cancer include undescended testicle, family and personal history of testicular cancer. Learn about testicular cancer risk.
A 7-month-old infant showed bilateral enlarged, nontender scrotal masses. The level of α-fetoprotein was greater than 10,000 ng/ml preoperatively; a high left inguinal orchiectomy was performed for a suspected yolk-sac tumor. The right testis was diagnosed as a mature teratoma because it was not possible to establish a line of cleavage between the tumor and the normal tissue, and a high right inguinal orchiectomy was performed. Only one case of bilateral testicular teratomas has been reported in the literature to date. We report a rare second case of bilateral testicular tumors, one a yolk-sac tumor and the other a teratoma.
Testicular cancer represents the more frequent solid tumour affecting males aged 15-35 years.In the last decades, its incidence showed a progressive increased probably due to genetic and environmental factors. Despite exposure to some viruses such as HIV, HCV, EBV and HPV is frequently related to cancer development, there are no studies aimed to evaluate the possible implication of viral infections in the pathogenesis of testicular cancer. In this study we analyzed sperm parameters and prevalence of HPV on sperm in 155 testicular cancer patients at diagnosis (T-1), after orchiectomy (T0) and after 12 months from surgery or from the end of adjuvant treatments (T12). All patients showed a significantly higher prevalence of semen infection than controls (9.5% and 2.4% respectively) and altered sperm parameters both at T-1 and T0. Considering sperm parameters, at T-1 we observed a reduction of progressive motility, and after orchiectomy patients showed a reduction of sperm concentration and count and a
The National Institute for Health and Clinical Excellence (NICE) issued full guidance to the NHS in England, Wales, Scotland and Northern Ireland on laparoscopic retroperitoneal lymph node dissection for testicular cancer in March 2006. In accordance with the Interventional Procedures Programme Process Guide, guidance on procedures with special arrangements are reviewed 3 years after publication and the procedure is reassessed if important new evidence is available.. The guidance was considered for reassessment in March 2009 and it was concluded that NICE will not be updating this guidance at this stage. However, if you believe there is new evidence which should warrant a review of our guidance, please contact us via the email address below.. ...
Status: Recruiting. Condition Summary: Adult Solid Tumor; Adenocarcinoma of the Colon; Adenocarcinoma of the Rectum; Adult Central Nervous System Germ Cell Tumor; Adult Teratoma; Benign Teratoma; Estrogen Receptor-negative Breast Cancer; Estrogen Receptor-positive Breast Cancer; Familial Testicular Germ Cell Tumor; HER2-negative Breast Cancer; HER2-positive Breast Cancer; Male Breast Cancer; Ovarian Immature Teratoma; Ovarian Mature Teratoma; Ovarian Monodermal and Highly Specialized Teratoma; Progesterone Receptor-negative Breast Cancer; Progesterone Receptor-positive Breast Cancer; Recurrent Breast Cancer; Recurrent Colon Cancer; Recurrent Extragonadal Germ Cell Tumor; Recurrent Extragonadal Non-seminomatous Germ Cell Tumor; Recurrent Extragonadal Seminoma; Recurrent Malignant Testicular Germ Cell Tumor; Recurrent Melanoma; Recurrent Ovarian Germ Cell Tumor; Recurrent Rectal Cancer; Stage III Extragonadal Non-seminomatous Germ Cell Tumor; Stage III Extragonadal Seminoma; Stage III Malignant ...
INDIANAPOLIS - Indiana University cancer researchers found that many testicular cancer survivors have low testosterone levels and are more likely to have chronic health problems.. In the study, the researchers found that 38 percent of 491 testicular cancer survivors had low testosterone levels, or hypogonadism. Further, compared to survivors with normal testosterone levels, survivors with low testosterone were more likely to report a range of chronic health problems such as high blood pressure, diabetes and erectile dysfunction.. Because testicular cancer is the most common cancer among young men and is highly curable, many survivors may live more than 40 years after diagnosis, Mohammad Issam Abu Zaid, MBBS, an assistant professor of medicine at IU School of Medicine and lead author, said. Our findings underscore the need to screen testicular cancer survivors for hypogonadism and treat those who have symptoms.. Dr. Abu Zaid, who completed his hematology-oncology fellowship at the Indiana ...
CASTILLO C, OCTAVIO A et al. Robotic-assisted laparoscopic retroperitoneal lymph node dissection in post chemotherapy residual mass in testis cancer. Rev Chil Cir [online]. 2011, vol.63, n.5, pp.508-512. ISSN 0718-4026. http://dx.doi.org/10.4067/S0718-40262011000500012.. Introduction: The laparoscopic retroperitoneal lymph node dissection (L-RPLND) has shown results at least comparable to open surgery in terms of perioperative complications and oncological results, but its application in the post chemotherapy scenario is still matter of study. The development of robotic surgery and its advantages over laparoscopic surgery, make this an attractive option for complex procedures. We report our initial experience with robotic-assisted retroperitoneal lymph node dissection (R-RPLND). Methods: We describe the cases of two patients who underwent R-RPLND due to a Post Chemotherapy residual mass of a non-seminomatous testicular cancer. Results: Two patients, 27 and 30 years old, presented with ...
The cells are generally packed into nodules, and have a loose, sheet-like arrangement that is commonly interrupted by interstitial oedema. Unlike classical seminoma, fibrous septation and lymphocytic infiltrates are not seen. Cells undergoing mitosis are common, as are cells undergoing apoptosis.[1] Intratubular growth of spermatocytic seminoma can be seen, however there is no intratubular germ cell neoplasia of unspecified type (IGCNU). The intratubular growth probably accounts for the appearance of separate tumour nodules within the testis. Immunostaining for most of the usual testicular germ cell tumour markers is negative (i.e. placental alkaline phosphatase (PLAP), vimentin, actin, desmin, alpha fetoprotein (AFP), OCT4, human chorionic gonadotropin (hCG), and carcinoembryonic antigen (CEA)). Rarely, spermatocytic seminomas may show sarcomatoid differentiation, most commonly as undifferentiated spindled cells intermingled within the typical-appearing spermatocytic seminoma cells. ...
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Adult Solid Tumor Adenocarcinoma of the Colon Adenocarcinoma of the Rectum Adult Central Nervous System Germ Cell Tumor Adult Teratoma Benign Teratoma Estrogen Receptor-negative Breast Cancer Estrogen Receptor-positive Breast Cancer Familial Testicular Germ Cell Tumor HER2-negative Breast Cancer HER2-positive Breast Cancer Male Breast Cancer Ovarian Immature Teratoma Ovarian Mature Teratoma Ovarian Monodermal and Highly Specialized Teratoma Progesterone Receptor-negative Breast Cancer Progesterone Receptor-positive Breast Cancer Recurrent Breast Cancer Recurrent Colon Cancer Recurrent Extragonadal Germ Cell Tumor Recurrent Extragonadal Non-seminomatous Germ Cell Tumor Recurrent Extragonadal Seminoma Recurrent Malignant Testicular Germ Cell Tumor Recurrent Melanoma Recurrent Ovarian Germ Cell Tumor Recurrent Rectal Cancer Stage III Extragonadal Non-seminomatous Germ Cell Tumor Stage III Extragonadal Seminoma Stage III Malignant Testicular Germ Cell Tumor Stage III Ovarian Germ Cell Tumor Stage IV ...
Adult Solid Tumor Adenocarcinoma of the Colon Adenocarcinoma of the Rectum Adult Central Nervous System Germ Cell Tumor Adult Teratoma Benign Teratoma Estrogen Receptor-negative Breast Cancer Estrogen Receptor-positive Breast Cancer Familial Testicular Germ Cell Tumor HER2-negative Breast Cancer HER2-positive Breast Cancer Male Breast Cancer Ovarian Immature Teratoma Ovarian Mature Teratoma Ovarian Monodermal and Highly Specialized Teratoma Progesterone Receptor-negative Breast Cancer Progesterone Receptor-positive Breast Cancer Recurrent Breast Cancer Recurrent Colon Cancer Recurrent Extragonadal Germ Cell Tumor Recurrent Extragonadal Non-seminomatous Germ Cell Tumor Recurrent Extragonadal Seminoma Recurrent Malignant Testicular Germ Cell Tumor Recurrent Melanoma Recurrent Ovarian Germ Cell Tumor Recurrent Rectal Cancer Stage III Extragonadal Non-seminomatous Germ Cell Tumor Stage III Extragonadal Seminoma Stage III Malignant Testicular Germ Cell Tumor Stage III Ovarian Germ Cell Tumor Stage IV ...
A group of 2,739 infertile men whose testes were biopsied during the investigation of infertility in the period from January 1955 to December 1992 have been reviewed. Unilateral intratubular germ cell neoplasia was seen in the testicular biopsies of 16 patients and was always associated with testicular atrophy (Johnsen score lower than 4). Germ cell tumors of the testis occurred in 50% of untreated patients within 6 years and the longest period of tumor-free follow-up was 10 years. A retrospective study was performed to evaluate the incidence of tumors in a subset of 1,639 infertile men biopsied between 1955 and 1982. Three of the patients, without intratubular germ cell neoplasia on the biopsy, were found to have developed a germ cell tumor. The incidence and management of intratubular germ cell neoplasia in infertile men is discussed.. ...
TY - JOUR. T1 - Robot-assisted retroperitoneal lymph node dissection. T2 - Technique and initial case series of 18 patients. AU - Cheney, Scott M.. AU - Andrews, Paul E.. AU - Leibovich, Bradley C.. AU - Castle, Erik P.. N1 - Publisher Copyright: © 2014 The Authors. BJU International © 2014 BJU International.. PY - 2015/1/1. Y1 - 2015/1/1. N2 - Objective To evaluate outcomes of the first 18 patients treated with robot-assisted retroperitoneal lymph node dissection (RA-RPLND) for non-seminomatous germ cell tumours (NSGCT) and paratesticular rhabdomyosarcoma (RMS) at our institution.Patients and Methods Between March 2008 and May 2013, 17 patients underwent RA-RPLND for NSGCT and one for paratesticular RMS. Data were collected retrospectively on patient demographics, preoperative tumour characteristics, and perioperative outcomes including open conversion rate, lymph node (LN) yield, rate of positive LNs, operative time, estimated blood loss (EBL), and length of stay (LOS). Perioperative ...
Retroperitoneal lymph node dissection (RPLND) is surgery often used to treat testicular cancer. It is done to remove lymph nodes that may be cancerous from the lower back and pelvis.. During the early phases of stage I nonseminoma testicular cancer, it can be very difficult to tell whether these lymph nodes are cancerous without surgically removing them first. For this reason, RPLND may be done even though there is no sign that the cancer has spread (metastasized) beyond the testes.. For many men, the greatest risk associated with RPLND may be sexual side effects. Besides the risks related to any major surgery, RPLND also may lead to a condition known as retrograde ejaculation as a result of nerve damage caused by the surgery. In retrograde ejaculation, the semen flows from the prostate gland into the bladder rather than through the penis and outside the body, resulting in infertility. Men who suffer from retrograde ejaculation typically do not have erection problems or difficulty enjoying ...
Patients with cryptorchidism are at an increased risk for germ cell testicular cancer. OCT 4 has been shown to be a sensitive and specific marker for some types of germ cell testicular cancer. We undertook this study to establish whether OCT 4 immunohistochemistry is a useful tool in the pathohistologic evaluation of postpubertal patients with cryptorchidism. Seventeen postpubertal patients underwent orchidectomy for cryptorchidism at our center since 1997. Immunohistochemical staining with OCT 4 was performed on these samples. Characteristic OCT 4 nuclear staining was positive in two patients. One patient was correctly diagnosed on previous pathohistological evaluation, while OCT4 immunohistochemical staining revealed previously unidentified intratubular germ cell neoplasia in the other patient. OCT 4 immunohistochemistry can be useful in diagnosing a testicular germ cell tumor in patients with cryptorchidism. If we consider a low number of postpubertal patients with cryptorchidism a benefit of ...
PURPOSE: Long-term cancer survivors may develop psychological late effects. The aim of the present study was to determine prevalence of high level of stress in testicular cancer survivors (TCS) compared with the general population and prevalence of high level of stress among TCS stratified by type of treatment (surveillance, bleomycin, etoposide and cisplatin (BEP), or abdominal radiotherapy (RT)).. METHODS: In this large, nationwide and population-based, cross-sectional study, a total of 2252 TCS filled in a questionnaire between 2014-2016 covering psychological stress (Perceived Stress Scale (PSS)), sociodemographic factors, and physical health variables. Results were compared with a reference population. The reference population consisted of 61,927 men without prior or present cancer and sampled at random from the central population. High level of stress was defined as a PSS score ≥ 16, equivalent to the highest scoring quintile in the reference population. Logistic regression models ...
A narrative review of the surgical principles of primary and post- chemotherapy retroperitoneal lymph node dissection for non- seminomatous germ cell tumors
AUA 2018 Retroperitoneal lymph node dissection (RPLND) for testis cancer, robotic RPLND may offer similar oncologic outcomes to the traditional open procedure, population-based approach Retroperitoneal lymph node dissection study for testis cancer.
Cryptorchism is an established risk factor for testicular cancer, but the role of age at surgical correction is unclear. The authors investigated this relation using information obtained from comprehensive medical records dating to childhood. They conducted a case-control study of 183 Kaiser Permanente members, who were diagnosed with testicular cancer during 1973-1996 and who were 15 years or younger when they first joined the health plan, and 551 controls. Notes pertaining to the testes were reviewed up to the cases diagnosis date or comparable date among the controls. The odds ratio for the association of a history of cryptorchism with testicular cancer risk was 4.8 (95% confidence interval (CI): 1.9, 11.8). Compared with no history of cryptorchism, men with a history who had natural descent or successful orchiopexy by the 11th birthday were not at increased risk of testicular cancer (odds ratio = 0.6, 95% CI: 0.08, 5.4). However, successful treatment of cryptorchism only after the 11th ...
The 1997 International Germ Cell Consensus Classification[9] is a tool for estimating the risk of relapse after treatment of malignant germ cell tumor. A small study of ovarian tumors in girls[10] reports a correlation between cystic and benign tumors and, conversely, solid and malignant tumors. Because the cystic extent of a tumor can be estimated by ultrasound, MRI, or CT scan before surgery, this permits selection of the most appropriate surgical plan to minimize risk of spillage of a malignant tumor. Access to appropriate treatment has a large effect on outcome. A 1993 study of outcomes in Scotland found that for 454 men with non-seminomatous (non-germinomatous) germ cell tumors diagnosed between 1975 and 1989, 5-year survival increased over time and with earlier diagnosis. Adjusting for these and other factors, survival was 60% higher for men treated in a cancer unit that treated the majority of these men, even though the unit treated more men with the worst prognosis.[11] Choriocarcinoma ...
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Recent genome-wide association studies (GWAS) and subsequent meta-analyses have identified over 25 SNPs at 18 loci, together accounting for ,15% of the genetic susceptibility to testicular germ cell tumour (TGCT). To identify further common SNPs associated with TGCT, here we report a three-stage experiment, involving 4098 cases and 18 972 controls. Stage 1 comprised previously published GWAS analysis of 307 291 SNPs in 986 cases and 4946 controls. In Stage 2, we used previously published customised Illumina iSelect genotyping array (iCOGs) data across 694 SNPs in 1064 cases and 10 082 controls. Here, we report new genotyping of eight SNPs showing some evidence of association in combined analysis of Stage 1 and Stage 2 in an additional 2048 cases of TGCT and 3944 controls (Stage 3). Through fixed-effects meta-analysis across three stages, we identified a novel locus at 3q25.31 (rs1510272) demonstrating association with TGCT [per-allele odds ratio (OR) = 1.16, 95% confidence interval (CI) = ...
A higher incidence of germ cell testicular cancer was found in Maoris 6.84/100,000 compared with non-Maoris 5.26/100,000 in New Zealand from 1975 to 1986, especially in the 15-49 year age group Maoris 12.30/100,000, non-Maoris 9.47/100,000; P=0.04. Previous studies have shown Whites to have the highest incidence of this malignancy. Possible...
We studied 137 primary testicular germ cell tumors (TGCTs) using high-dimensional assays of genomic, epigenomic, transcriptomic, and proteomic features. These tumors exhibited high aneuploidy and a paucity of somatic mutations. Somatic mutation of only three genes achieved significance-KIT, KRAS, an …
A collection of disease information resources and questions answered by our Genetic and Rare Diseases Information Specialists for Nonseminomatous germ cell tumor
TY - JOUR. T1 - Fertility considerations in nerve-sparing retroperitoneal lymph-node dissection. AU - Foster, R. S.. AU - McNulty, A.. AU - Rubin, L. R.. AU - Bennett, R.. AU - Rowland, R. G.. AU - Sledge, G. W.. AU - Bihrle, R.. AU - Donohue, J. P.. PY - 1994/6/1. Y1 - 1994/6/1. N2 - Nerve-sparing retroperitoneal lymph-node dissection (RPLND) maintains the patients ability to ejaculate postoperatively. However, since testicular cancer patients sometimes have diminished spermatogenesis, questions have been raised as to the advisability of nerve preservation relative to ultimate fertility. Fertility status was assessed in clinical stage A patients by two methods. These included standard semen analysis and a post-RPLND survey. The results show that approximately 75% of nonseminomatous testicular cancer patients who present in clinical stage A have fertility potential as based on semen analysis. Additionally, of those patients responding to the post-RPLND survey who had attempted pregnancy ...
Looking for interstitial cell tumor? Find out information about interstitial cell tumor. A crystal defect in which an atom occupies a position between the regular lattice positions of a crystal. Of, pertaining to, or situated in a space between... Explanation of interstitial cell tumor
Germ cell tumors are malignant (cancerous) or nonmalignant (benign, noncancerous) tumors that are comprised mostly of germ cells. Germ cells are the cells that develop in the embryo (fetus, or unborn baby) and become the cells that make up the reproductive system in males and females. These germ cells follow a midline path through the body after development and descend into the pelvis as ovarian cells or into the scrotal sac as testicular cells. Most ovarian tumors and testicular tumors are of germ cell origin. The ovaries and testes are called gonads.. Tumor sites outside the gonad are called extragonadal sites. The tumors also occur along the midline path and can be found in the head, chest, abdomen, pelvis, and sacrococcygeal (lower back) area.. Germ cell tumors are rare, as only about 2.4 children in one million will develop one of these tumors in a given year. Germ cell tumors account for about 4 percent of all cancers in children and adolescents younger than age 20.. Germ cell tumors can ...
What is the difference between Seminoma and Nonseminoma? Seminoma and nonseminoma are different varieties of testicular tumors. Unlike nonseminomas, seminomas..
Genetic Determinants of Cisplatin Resistance in Patients With Advanced Germ Cell Tumors. Bagrodia A, Lee BH, Lee W, et al. J Clin Oncol. 2016;34(33):4000-4007. doi:10.1200/JCO.2016.68.7798. Serum MicroRNA-371a-3p Levels Predict Viable Germ Cell Tumor in Chemotherapy-naïve Patients Undergoing Retroperitoneal Lymph Node Dissection. Lafin JT, Singla N, Woldu SL, Lotan Y, Lewis CM, Majmudar K, Savelyeva A, Kapur P, Margulis V, Strand DW, Murray MJ, Amatruda JF, Bagrodia A. Eur Urol. 2020 Feb;77(2):290-292. doi: 10.1016/j.eururo.2019.10.005. Epub 2019 Nov 5. PMID: 31699528.. MicroRNAs: Turning the Tide in Testicular Cancer. Singla N, Lafin JT, Bagrodia A. Eur Urol. 2019 Nov;76(5):541-542. doi: 10.1016/j.eururo.2019.06.010. Epub 2019 Jun 21. PMID: 31230742.. Genetics of Testicular Germ Cell Tumors. Singla N, Lafin JT, Ghandour RA, Kaffenberger S, Amatruda JF, Bagrodia A. Curr Opin Urol. 2019 Jul;29(4):344-349. doi: 10.1097/MOU.0000000000000642. PMID: 31045925; PMCID: PMC6659740.. A New Model to ...
Background: Testicular Mixed Germ Cell Tumour (MGCTS) is a rarely reported. En bloc vena caval resection of involved tumours or extensive thrombosis c..
OBJECTIVE: To examine the nodal (N+) vs extranodal (M+) staging in each of the International Germ Cell Consensus Classification Group (IGCCCG) subgroups in an audit of 437 patients treated in The Anglian Germ Cell Cancer Group, where chemotherapy was the primary management, as there is an increasingly earlier presentation of patients with less advanced disease who thus face potentially unnecessary treatment. PATIENTS AND METHODS: Clinicians from seven centres prospectively registered patients in a central database, and the follow-up was coordinated by one of the authors. RESULTS: Between 1982 and 2002, 436 patients (median follow-up 60 months) were registered; 63% of IGCCCG good risk (298), 42% of intermediate (62) and 8% poor risk (77) were stage II; 79% of N+M0 intermediate and poor risk cases (29) were alive, vs only 60% of M+ stage IV cases (92, P | 0.05). The trend was similar in IGCCCG good risk patients, with 92% of N+ stage II (156) alive vs only 85% (94) of stage IV M+ (not significant). The
The human testicular germ cell cancer, seminoma, is one of the most common cancers of young men, and increasing in prevalence globally. To better understand mechanisms that govern viability, proliferation, and migration in testicular cancers, we used the TCam-2 seminoma cell line to model seminoma responses to four major signalling pathways: TGFb, retinoic acid (RA), Hedgehog, and WNT. Transcript, immunohistochemical, and functional analyses show TCam-2 cells are responsive to activation/suppression of all four pathways, and highlighted potential crosstalk points in these cells. Activation of TGFb signalling by BMP4 supports TCam-2 viability in the absence of serum, and suppression of canonical WNT signalling at the intracellular level with either IWR-1 or CCT036477 leads to loss of viability (measured by propidium iodide incorporation) and decreased migration (wound healing assay). These pathways exhibit crosstalk in embryonic stem cells to reduce pluripotency network transcripts, and may also ...
The frequency of germ cell tumors is about 1% of all male cancers. The incidence increases in developed countries. The prevalence is the highest among the young males. The histologic type, extent of disease and therapy is based on international guidelines. The surgery, radio- and chemotherapy can achieve cure in the germ cell cancer patients. Regarding the late toxicity, the minimal invasive tumors are suggested to keep on the wait and see policy. The complex therapy of poor risk groups reached more than 80% permanent remission rate. The chemotherapy is based on cisplatin, but in second and third line therapy paclitaxel, gemcitabin and oxaliplatin is widely used. After the cure of germ cell cancer patients the careful follow up is mandatory.. ...
Testicular cancer (TC) survivors have an increased risk of various second primary malignancies. A recent cohort study detected an increased risk of colorectal cancer (CRC) in TC survivors treated with platinum-based chemotherapy with a hazard ratio of 3.9. CRC risk increased with higher cisplatin-dose. We know that colonoscopy surveillance in high-risk populations results in reduced incidence and mortality of CRC. TC survivors treated with platinum-based chemotherapy can potentially benefit from colonoscopy surveillance; however, to which extent is unknown. Furthermore, the pathogenesis of these secondary CRCs is unknown, and better insights into the carcinogenesis may affect surveillance decisions. This prospective multicenter study will be performed in four Dutch hospitals. TC survivors are eligible if treated with ≥ 3 cycles of cisplatin before age 50. Colonoscopy will be performed ≥ 8 years after initial treatment (minimum and maximum ages at colonoscopy, 35 and 75 years, respectively). The
Health,INDIANAPOLIS -- Testicular cancer patients who do not respond to traditional therapy can be cured with high-dose chemotherapy and a stem cell transplant according to an Indiana University School of Medicine report in the July 26 issue of the New England Journal of Medicine. About 90 percent of testicular cancer patients respond to traditional therapy which involves multiple courses o,Advanced,therapy,offers,cure,for,relapsed,cancer,patient,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news
Eighty-two patients with metastatic germ cell tumors (GCT) treated with two-drug therapy consisting of etoposide and cisplatin were evaluated for late relapse. Good-risk GCT was defined using Memorial Sloan-Kettering Cancer Center (MSKCC) criteria. Etoposide was given at 100 mg/m2 on days 1 to 5 and cisplatin was given at 20 mg/m2 on days 1 to 5; therapy was recycled at 21 days with delays up to 7 days for a leukocyte count of less than 3000/microliters or a platelet count of less than 100,000/microliters. Drug doses were not attenuated for myelosuppression. Seventy-six of 82 evaluable patients achieved a complete response (CR). Seventy-two patients had a CR to chemotherapy alone. Forty-six (56%) patients had excision of residual abnormalities: 11 had teratoma in the resected specimen, 31 had necrotic debris or fibrosis, and 4 had a CR after chemotherapy plus complete excision of residual viable GCT. Six patients had an incomplete response to chemotherapy; one of these patients had unresectable ...
Treatment. Radical orchidectomy and cisplatin-based chemotherapy was the most common treatment combination, and was done in 11 (46%) patients; radical orchidectomy only and radical orchidectomy with radiotherapy in 6 (25%) patients each; and laparotomy, excision of intra-abdominal testicular tumour and chemotherapy was done in 1 (4%) patient. Surgical complications included surgical site infection in 4 patients and adhesive small-bowel obstruction in the patient with intra-abdominal testes. Retroperitoneal lymph node dissection (RPLND) was not done on any of our patients as they refused consent after being informed of the ejaculatory difficulty that might follow. The reason behind these refusals was fear of infertility, which has strong cultural and social consequences in Africa. Cisplatin-based combination chemotherapy using the BEP regimen (bleomycin, etoposide, cisplatin) was commenced 7 - 14 days postoperatively in 10 patients, while 2 patients with scrotal skin involvement received ...
TY - JOUR. T1 - Pre-pubertal and adolescent germ cell neoplasms in Taiwan. T2 - Time trends and geographic variation. AU - Hung, G. Y.. AU - Horng, J. L.. AU - Yen, H. J.. AU - Lee, C. Y.. PY - 2015/9/1. Y1 - 2015/9/1. N2 - Evidence from our previous study suggested that the incidence of germ cell neoplasms in children and adolescents is increasing. The objectives of this analysis were to quantify this trend in patients aged 0-9 and 10-19 years (pre-pubertal and adolescent groups, respectively) and compare rates in Taiwan according to geographic distribution. Germ cell neoplasm frequencies among 1267 patients aged 0-19 years spanning 1995-2009 were obtained from the population-based Taiwan Cancer Registry. The incidence patterns according to sex, age, disease subgroup, and geographic distribution were analyzed. The incidence rates in the pre-pubertal and adolescent groups were 10.58 and 16.06 per million person-years, respectively. The overall rates increased significantly by 3.2% annually in ...
A consecutive series of 13 children (five girls) with advanced malignant germ cell tumors (MGCTs) were treated with between four and seven (median, six) courses of cisplatin, bleomycin, and either vinblastine (BVP) or VP-16 (BEP). There were seven gonadal primaries (four testis, three ovary) and six at extragonadal sites (three sacrococcyx, two thoracic, one extradural). Total or subtotal removal of primary tumor was carried out in nine patients at diagnosis and two others after some chemotherapy. Clinical complete remission (CR) was achieved in nine of ten patients with measurable disease and serum markers returned to normal in all 13 patients. Eleven remain disease-free 17 to 48 months (median, 28 months) after diagnosis. One patient (stage IV sacrococcygeal tumor) relapsed at the primary site 3 months after completing treatment, but is disease-free after further surgery, radiotherapy, and chemotherapy. Serial glomerular filtration rates were performed during treatment. Audiometry and ...
Authors discuss the most up-to-date research on using chemotherapy treatments for good-risk germ cell tumors, focusing on the use of post-chemotherapy retroperitoneal lymph node dissection and the need for continued, longer-term studies.
The study of testicular germ cell tumors (GCTs) is a unique area of urologic oncology, as treatment algorithms have benefited from numerous randomized prospective clinical trials (unlike prostate cancer) and because metastatic disease is highly responsive to multimodal treatment (unlike renal cell carcinoma). Seminoma is a histologic subtype ...
TY - JOUR. T1 - Current concepts in risk factor assessment for advanced germ cell cancer. AU - Garzotto, M.. AU - Nichols, C. R.. PY - 2001/9/15. Y1 - 2001/9/15. N2 - Disseminated germ cell tumors (GCT) have come to represent the model for a curable malignancy, as cure rates with cisplatin-based chemotherapy coupled with appropriate surgery are 70% to 80%. For patients with favorable prognostic factors who achieve and maintain a complete response, the outlook is good. However, despite advances in the treatment of this disease, a significant number of patients with metastatic GCT fail to respond either primarily or secondarily. Being able to identify poor-risk patients up front would allow for appropriate selection of candidates for high-risk trials. Several different classification systems were previously developed at several treatment centers in the United States and Europe. These models recognized different clinical variables as prognosticators and had unique functional properties. However, ...