The World Health Organization (WHO), the U.S. Department of Health, and Human Services (HHS) and other like-minded organizations and governments are committed to assisting in the creation of regionally-based, independent and sustainable vaccine production capacity in developing and emerging economy countries through capacity building and technology transfer. As a means of initiating a coordinated discussion among the international community regarding this shared goal, WHO and HHS convened the Sustainable Influenza Vaccine Production Capacity Stakeholders Workshop in Washington D.C. in January 2010. A key theme that emerged during the workshop discussions was the fact that sustainable vaccine production capacity cannot be achieved in the absence of robust national regulatory systems. A robust regulatory system is one the exhibits the capability to perform their regulatory functions with consistency under a wide range of conditions. There is a need to increase the current investment by WHO in ...
A semi-automated coating system for providing medical devices with antimicrobial coatings is disclosed. The semi-automated coating system extends the coating solutions usable life span by minimizing exposure to light, air and temperature extremes. Moreover, the disclosed semi-automated coating system minimizes operator and environmental exposure to the coating solutions. Methods disclose techniques for preparing coating solutions, setting up the coating system and operating the device. Moreover, the systems and methods described herein minimize operator intervention with the coating processes and provide superior product consistency.
Summary Various properties of five protective coating systems have been investigated under arctic conditions. Arctic conditions have been defined as temperatures down to 60°C. Ageing resistance testing according to ISO 20340 with -60°C in the freezer instead of the specified -20°C showed acceptable performance for several of the tested samples. The reinforced polyester coating system was highly resistant towards corrosion creep. The vulcanized rubber coating and a conventional three-coat paint system showed good performance with respect to rust creep. However, the polysiloxane topcoat cracked during testing. The coating system with the polysiloxane topcoat also showed cracking in different mechanical tests and failed in several of the impact resistance test. Generally, mechanical testing at or below -30°C showed harder and less flexible/more brittle coatings ...
Author: Allen Loyd V Jr, Year: 2019, Abstract: Process analytical technology was introduced by the U. S. Food and Drug Administration about 20 years ago to assist the pharmaceutical industry in making changes that should reduce batch failures, ensure performance, and enhance quality. Its premise is that
Inquire for Global Process Analytical Technology (PAT) Market Competitive Analysis, Trends, Player Strategies and Forecast till 2022, with free sample.
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In this webinar you will learn how to: •Create your own film-coating colors •Improve production efficiencies •Increase process robustness •Reduce process complexity with Kollicoat® IR Coating Systems - easy to disperse complete coating systems with excell...
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U.S. 8,138,249 B2 BASF Coatings Japan Ltd. has been awarded a patent for a two-component coating system comprised of a component (a) comprised of one or more polyisocyanates, a component (b) comprised of one or more oligomeric and/or poly
Axalta Coating Systems (NYSE: AXTA), a leading global supplier of liquid and powder coatings, announced today that its new Global Innovation Center wi
MediCoat BC is an automated Balloon Catheter Coating system for spraying anti-restenosis solutions containing Paclitaxel or bioabsorbable polymers onto implantable balloon catheters.
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A dry film coating composition for forming a coating suspension for film coating pharmaceuticals, food, confectionery forms, agricultural seeds, and the like, comprises (1) a primary film former, the primary film former comprising low bloom strength gelatin, or hydroxyethyl cellulose, or a combination thereof, and (2) a secondary film former, or a plasticizer, or a surfactant, or a glidant, or a suspension aid, or a colorant, or a flavorant, or a combination thereof.
Qinsheng Pharmaceutical Technology Co.,LTD. is located in Shanghai, where is economic financial, shipping and logistics center of China. We are a leading pharmaceutical company, honored as the high-tech enterprise which engaged in researching, manufacturing and exporting advanced pharmaceutical intermediates, Active Pharmaceutical Ingredients (API) and other fine chemicals ...
Pharm Methods Pharmaceutical Methods 2229-4708 2229-4716 Phcog.Net India Pharm Methods-9-8 10.5530/phm.2018.1.2 Original Article Application of Box-Behnken Design for Validation of High-Per Formance Thin-Layer Chromatography/Densitometry Method for Robustness Determination of Apremilast in Bulk and in-house Tablets Chaudhari Suraj Rajendra 1 Shirkhedkar Atul Arun 2 *
The Impact of Different Granulation Processes such as Wet Granulation and Hot Melt Granulation of Hydroxypropyl cellulose, HPC-SSL/SFP on the Physical and mechanical Properties of Ibuprofen ...
Pharmaceutical Technology is the independent source for information, insight, and analysis on bio/pharmaceutical formulation, development, and manufacturing.
Joe DiMasi, director of economic analysis and research associate professor, Tufts Center for the Study of Drug Development (CSDD), discussed research into the impacts of working with single source contractors with Pharmaceutical Technology. ...
INTERPHEX AND PHARMACEUTICAL TECHNOLOGY ANNOUNCE KEYNOTE SERIES PROGRAM NEW YORK, NY - March 13, 2019 - International Pharmaceutical Expo (INTERPHEX), the premier event dedicated to pharmaceutical and biotechnology innovation, technology and
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This purchase will enable Arrow Generiques to continue to increase its branded products portfolio and leverage its position as a key player in the drug market.. Arrow Generiques focuses on selling generics for the retail and hospital markets in France since 2002.. Arrow Generiques entered a strategy of diversification with the purchase of the first branded products a few years ago to become a company balanced between generics / branded products / biosimilars within the retail and hospital markets.. A business unit with a sales and marketing team had been set up to particularly improve this business.. This deal will bolster its presence of Arrow Generiques and open new opportunities for the future.. Aurobindo Pharma, headquartered at Hyderabad, India, manufactures generic pharmaceuticals and active pharmaceutical ingredients.. ...
The development and application of continuous manufacturing processes for vaccines presents both great opportunity as well as significant challenges, both technical and cultural, for the global industry. The key drivers are manufacturing capacity and flexibility, speed to market, and improved quality through the application of Quality-by-Design and Process Analytical Technology (QbD/PAT). Given the diversity of immunogens (toxoids, conjugate and subunit vaccines, live-attenuated and inactivated viruses, VLPs, etc.), and the variety of unique processes currently utilized to produce either single- or multi-component vaccines, it is unlikely that the transition to continuous processing will happen overnight. Additionally, cultural challenges are faced whenever a new mode of operation appears to some as too different, especially in a traditionally conservative sector like the developed-world vaccine industry. That said, market forces, global climate change, and Natures propensity to fill ...
This mini-review discusses how soft sensors can contribute to accomplish FDAs process analytical technology (PAT) ambitions in the manufacture of bio-therapeutics. Focus is on applications with protein-based drugs (proteins, antibodies), but also gene therapy vectors as well as cell cultures are considered where chemical and bio-analytical as well as mathematical and statistical methods are used as tools. An overview of existing soft sensor alternatives and how these can be configured to meet typical industrial needs is provided. It is noted how several of these needs coincide with the PAT regulatory incentives but do also address process economic aspects of bio-therapeutic manufacture. Evaluation of soft sensor alternatives is highlighted in relation to the production targets, quality attributes and the specification of these as well as shortcomings and needs for further improvements.. ...
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Verbal Presentations and Posters. CALL FOR PAPERS - OPEN!. Please Submit Your Abstract Online. The three day forum will focus on the latest developments in Process Analytical Technologies...emerging techniques, new applications, instrumentation, software, standards, and a look into the future. You are cordially invited to submit an abstract for the forum. Listed below are some of the topics.. ...
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This is the default operator. It will be used if there is no Boolean operator between two terms. For example: default document is the same as default AND document. In this case both terms need to exist within a listing to find a match on that listing.The + character is synonymous with using AND. OR ...
Ireland-based biopharmaceutical company Jazz Pharmaceuticals plans to raise $500m through a private placement of senior notes.. The company plans to use the proceeds towards general corporate purposes and business development.. Chinese pharmaceutical products provider Kangmei Pharmaceutical has completed a public offering of medium-term notes to raise CNY2bn ($299.58m).. Due 2022, the notes carry a coupon rate of 5.29%.. ...
Further development of nonlinear optical imaging for sensitive detection of Crystallinity in Amorphous PowdersLead: TaylorInstitution: PurdueDevelopment of Real-time Release Continuous Crystallization System with Anticrust ControlLead: NagyInstitution: Purdue
The Bachem Group (SWX: BANB) announced today that it has opened its new production unit at its US subsidiary Bachem California Inc. in Torrance, California. The expansion offers a forty percent increase in production capacity at the current facility for peptide-based active pharmaceutical ingredients (APIs) to meet increasing market demand in North America. The additional unit, representing an investment of about USD 10 million (CHF 12.5 million), fulfills all FDA requirements for cGMP production. ,media 1208 _blank external-link-new-window,Press Release,/media,. ...
Differential effect of metformin and/or glyburide on apelin serum levels in patients with type 2 diabetes mellitus: Concepts and clinical practice ...
Global Active Pharmaceutical Ingredients (API) Market, By Molecule (Small Molecule, Large Molecule), Type (Innovative Active Pharmaceutical Ingredients, Generic Innovative Active Pharmaceutical Ingredients), Type of Manufacturer (Captive API Manufacturer, Merchant API Manufacturer), Synthesis (Synthetic Active Pharmaceutical Ingredients and Biotech Active Pharmaceutical Ingredients), Chemical Synthesis (Acetaminophen, Artemisinin, Saxagliptin, Sodium Chloride, Ibuprofen, Losartan Potassium, Enoxaparin Sodium, Rufinamide, Naproxen, Tamoxifen, Others), Type of Drug (Prescription Drugs, Over-the-Counter), Usage (Clinical, Research), Potency (Low-to-Moderate Potency Active Pharmaceutical Ingredients, Potent-to-Highly Potent Active Pharmaceutical Ingredient), Therapeutic Application (Cardiology, CNS & Neurology, Oncology, Orthopedic, Endocrinology, Pulmonology, Gastroenterology, Nephrology, Ophthalmology, Other Therapeutic Application), Country (U.S., Canada, Mexico, Germany, U.K., France, Italy, Spain,
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Chemical APIs (Active Pharmaceutical Ingredients) Spectrum Chemical manufactures and distributes over 400 chemical APIs (active pharmaceutical ingredients. These substances are the biologically active component of any drug product regardless of pharmaceutical formulation type (tablets, capsules, topical, etc.). Spectru
In the present study we investigated the effect of changes in the content of microcrystalline cellulose (MCC) on a direct pelletization process in a rotary processor in which the liquid addition was...
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Product Description Antidiabetic Active Pharmaceutical Ingredients Nateglinide CAS 105816-04-4 Product Name: Nateglinide Synonyms: (-)-n-(trans-4-isopropylcyclohexanecarbonyl)-d-phenylalanine;ay4166;Nateglinide(H);trans-d-phenylalanin;trans-n-((4-(1-methylethyl)cyclohexyl)carbonyl)-d-phenylalanine;3-phenyl-2-(4-propan-2-ylcyclohexyl)carbonylamino-propanoic acid;A-4166;STARLIX CAS: 105816-04-4 MF: C19H27NO3 MW: 317.42 Product Categories: Active Pharmaceutical Ingredients;API;APIs;Health & Beauty;Amino Acids & Derivatives;Intermediates & Fine Chemicals;Pharmaceuticals;Aromatics;STARLIX;Antidiabetic Melting point : 137-141°C Storage temp. : Room temp Chemical Properties : White Cyrstalline Solid Usage : antidiabetic KATP channel blocker…
(EMAILWIRE.COM, November 24, 2017 ) In this report, the global Active Pharmaceutical Ingredients market is valued at USD XX million in 2017 and is projected to reach USD XX million by the end of 2021, growing at a CAGR of XX% during the period 2017 to 2021. Active Pharmaceutical Ingredients...
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PHILADELPHIA--(BUSINESS WIRE)--Axalta Coating Systems (NYSE: AXTA), a leading global supplier of liquid and powder coatings, will host the 2017 Axalta CSR Summit: The Chemistry of Partnership on Friday, September 22, 2017.
A process includes coating a substrate with a hydrophobic coating system including highly tetrahedral amorphous carbon that is a form of diamond-like carbon (DLC). In certain embodiments, the coating system is deposited on the substrate in a manner to increase its hydrophobicity. In certain embodiments, the coating system is deposited in a manner such that it has an average hardness of at least about 10 GPa, more preferably from about 20-80 GPa. In certain embodiments, the coating system includes first and second DLC inclusive layers that are deposited using one or more ion beam deposition devices, wherein different gases are used to deposit the respective DLC inclusive layers such that the overlying layer has greater scratch resistance characteristics than the underlying layer which functions as an anchoring layer.
As part of its ongoing expansion, G-S Plastic Optics of Rochester, N.Y., has installed a precision optical coating system built by Vacuum Process Tech
Sandra Cvijić (maiden name: Grbić) graduated from the Faculty of Pharmacy, University in Belgrade in 2003. She received a PhD in Medical Sciences - Pharmacy from the same University in 2011 (thesis entitled Development of biorelevant dissolution media for poorly water-soluble drug substances). In 2013, she was a visiting scientist at the Department of Biopharmaceutics and Pharmaceutical Technology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Mainz, Germany (three-months research stay founded by DAAD organization). In 2015, she finished postgraduate specialization studies in Pharmaceutical Technology (final paper entitled In silico biopharmaceutical characterization tools in formulation development of oral dosage forms).. Sandra Cvijić is an Assistant Professor in the Department of Pharmaceutical Technology and Cosmetology. She is involved in the development and delivery of undergraduate courses in Pharmaceutical Technology 2, Pharmaceutical Technology 3, ...
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article{149532, author = {Ameye, Dieter and KELEB, E and Vervaet, Chris and Remon, Jean Paul and ADAMS, E and MASSART, DL}, issn = {0928-0987}, journal = {EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES}, language = {eng}, pages = {247--251}, title = {Scaling-up of a lactose wet granulation process in Mi-Pro high shear mixers.}, volume = {17 (4-5}, year = {2002 ...
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Asia Pacific Active Pharmaceutical Ingredients (API) Market 2021-2027 by Synthesis (Synthetic, Biotech, HPAPI), Manufacturing Process (Captive, Merchant), Therapeutic Application, Drug Type, and Country: Trend Forecast and Growth Opportunity
HPLC ( High Performance Liquid Chromatography )System / India Testing Equipment for sale - Place of Origin: Gujarat India Brand Name: Analytical Technologies Model Number: Intelligent 2230 / 3000 Series Power: Electronic Usage: Pharmaceuticals,Bio-Pharma, Chemicals,Dy... Liquid Chromatography System: Chromatography Sy... HPLC: PREP HPLC PROCESS HPLC: PRODUCTION HPLC ION CHROMATOGRAPHY: GPC Gel Permeation Chromatography: Nano LC
Active pharmaceutical ingredients. Industrial implementation of anticancer apis and antitumor agents with laboratory modification of the process parameters based on the metabolic property of the strain.
The eco-compatible, energy-efficient, low environmental impact, gram scale, mechanochemical preparation of marketed drugs such as Nitrofurantoin (Furantin©, antibacterial agent), Dantrolene (Dantrium©, a muscle relaxant also used for prevention of malignant hyperthermia) and their structurally related derivatives, is herein reported. The solvent-, base- and waste-free stoichiometric ball-milling of 1-amino-hydantoin chlorohydrate and various aldehydes led to the more stable E-regioisomers selectively, in high yield and pure form without post-reaction work-up. Not a drop of organic solvent was used for the entire process and hydrazones were stable in the presence of water and gaseous HCl, formed during the synthesis. Comparative mechanochemical experiments were performed using diverse milling devices and jar materials, the Active Pharmaceutical Ingredients were analyzed by PXRD and green metrics are calculated.. ...
Enzymes like lipase in active pharmaceutical ingredient manufacturing mitigate the need for harsh chemicals. Discover how our enzymes optimize making APIs.
CENTURY PHARMACEUTICALS LIMITED - Manufacturer,Supplier and Exporter of Animal Health Products,Active Pharmaceutical Ingredients Products etc from Vadodara, Gujarat,India.
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TY - JOUR. T1 - Continuous Hydrolysis and Liquid-Liquid Phase Separation of an Active Pharmaceutical Ingredient Intermediate Using a Miniscale Hydrophobic Membrane Separator. AU - Cervera Padrell,Albert Emili. AU - Morthensen,Sofie Thage. AU - Lewandowski,Daniel Jacob. AU - Skovby,Tommy. AU - Kiil,Søren. AU - Gernaey,Krist V.. N1 - Special Issue: Continuous Processes 2012 © 2012 American Chemical Society. PY - 2012. Y1 - 2012. N2 - Continuous hydrolysis of an active pharmaceutical ingredient intermediate, and subsequent liquid-liquid (L-L) separation of the resulting organic and aqueous phases, have been achieved using a simple PTFE tube reactor connected to a miniscale hydrophobic membrane separator. An alkoxide product, obtained in continuous mode by a Grignard reaction in THF, reacted with acidic water to produce partially miscible organic and aqueous phases containing Mg salts. Despite the partial THF-water miscibility, the two phases could be separated at total flow rates up to 40 mL/min ...
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The latest research report on Penicillin Active Pharmaceutical Ingredients market intends to provide opportunities to organizations operating in this industry through a...
India is considered as Pharmacy to The World, especially during the on going Covid-19 Pandemic. For Last one decade or so, the production of Active Pharmaceutical Ingredients has increased manifold. A large variety can be sourced from India. Sitting thousands of miles away it is difficult for you to know which company can offer you the right product at the right price. If you will give this task, knowing fully well who are the most reliable companies producing as per International standards, we shall be able to get you the right product at the right prices. Please send us your detailed inquiry whether you find your requirement in the list on this website or not?. ...
Active Pharmaceutical Ingredients (API) market size was valued at USD 179.77 billion in 2018 and is projected to reach to USD XX billion by 2026
Active Pharmaceutical Ingredients in Synthesis: Catalytic Processes in Research and Development Anthony J. Burke, PhD, is Professor at the University of Evora, and the coordinator of the organic and organometallic research line at the Centro de Química de Evora. Carolina S. Marques, PhD, is working as a PostDoc in the
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Edited by the three renowned researchers in the field, Comprehensive Quality by Design for Pharmaceutical Product Development and Manufacture guides pharmaceutical engineers and scientists involved in product and process development, as well as teachers, on how to utilize QbD practices and applications effectively while complying with government regulations. The material is divided into three main sections: the first six chapters address the role of key technologies, including process modeling, process analytical technology, automated process control and statistical methodology in supporting QbD and establishing the associated design space. The second section consisting of seven chapters present a range of thoroughly developed case studies in which the tools and methodologies discussed in the first section are used to support specific drug substance and drug-product QbD related developments. The last section discussed the needs for integrated tools and reviews the status of information ...
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At Plast 2018, leading size reduction equipment manufacturer Rapid Granulator is introducing a new range of granulators designed specifically for in-line processing of skeletal waste from sheet and film thermoforming lines. The new patent-pending ThermoPRO Series - based on an already patented Rapid design - is available in various standard and low-built formats for handling scrap widths from 600 to 1,500 mm (24-60 in.). A ThermoPRO 400-90 for granulating webs up to 900 mm in width (35 in.) will be on display at the companys booth, B102, Pav. 15, during Plast 2018, 29 May - 1 June in Milan.
Wet granulation of microcrystalline cellulose (MCC) has the objective of minimizing particle losses caused by elutriation in compression and coating processes. The MCC physical properties suggest the conventional fluidized bed as adequate for the granulation process; however, literature reports the occurrence of poor fluidization dynamic (preferential channels and dead zones) during this particle fluidization. This work reports the granulation of MCC in vibrofluidized bed, using aqueous solution of maltodextrin (35%) as binder. A fractional experimental design (2(5-1)) was developed to assess the influence of process variables: amplitude and frequency of vibration, atomization pressure, inlet air temperature, and granulating solution flow rate on the responses: particle growth, angle of repose, lump index and mass of elutriated particles. The results showed an increase of the Sauter mean diameter related to the original value from 3.17 to 33.11%, confirming the granulation of the material. The ...
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Based on a natural compound (omega-3 fatty acids insoluble in water)and by using pharmaceutical technology,the product was combined with a synthetic product(morphine soluble in water)for
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Its usually known that the particle size and particle shape are two irrelevant concepts. But our research shows that the token of particle size is not only related to particle shape, but also related to particle measurement methods. This paper takes sheetlike graphite micropowder for example and gets the function relation between particle shape factor and particle size by analyzing the particle distribution data between laser diffraction and sedimentation. This research provides a new approach for the study of particle shape ...
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