Technetium Tc 99m Pyrophosphate: A radionuclide imaging agent used primarily in scintigraphy or tomography of the heart to evaluate the extent of the necrotic myocardial process. It has also been used in noninvasive tests for the distribution of organ involvement in different types of amyloidosis and for the evaluation of muscle necrosis in the extremities.
Figure 1. Optimized CCSD(T)/cc-pVQZ structures of HOCH isomers and their Focal Point relative energies (kcal mol-1).1. The barriers for rearrangement from 1t are both very high. Rearrangement to formaldehyde 2 requires crossing a barrier of 29.7 kcal mol-1, while the barrier to convert to the cis isomer 1c is 26.8 kcal mol-1. (Note that from 1c a cleavage into CO and H2 can occur, but this barrier is another 47.0 kcal mol-1.) These barriers are too large to be crossed at the very low temperatures of the matrices. However, using the intrinsic reaction potential at CCSD(T)/cc-pVQZ and WKB theory, the tunneling lifetime of HOCH is computed to be 122 minutes, in excellent accord with the experiment. The lifetime for DOCH is computed to be over 1200 years. Thus, the degradation of hydroxymethylene is entirely due to tunneling through a very large classical barrier! This rapid tunneling casts serious doubt on the ability to ever identify any hydroxymethylene in interstellar space.. ...
title: Prognostic significance of CA-125 re-elevation after interval debulking surgery in patients with advanced-stage ovarian cancer undergoing neoadjuvant chemotherapy, doi: 30337203, category: Article
Haloperidol (HPL), a widely used antipsychotic drug, is known to induce serious ventricular arrhythmias. However, the mechanism underlying their induction is not clear. We therefore examined the effects of HPL on the intracellular Ca,sup,2+,/sup, ([Ca,sup,2+,/sup,],sub,i,/sub,) transient and on cell motion in cultured cardiac myocytes, as well as the pathways involving the HPL-induced abnormality of Ca,sup,2+,/sup, homeostasis. HPL prolonged the diastolic phase of the Ca,sup,2+,/sup, transient, with a mid-diastolic re-elevation of [Ca,sup,2+,/sup,],sub,i,/sub,. The re-elevation of [Ca,sup,2+,/sup,],sub,i,/sub, was shown to be provoked by Ca,sup,2+,/sup, release from sarcoplasmic reticulum (SR), which can trigger delayed afterdepolarization, the major arrhythmogenic factor. The re-elevation of [Ca,sup,2+,/sup,],sub,i,/sub, coincided with cell re-contraction during diastole. The induction of this abnormality by HPL appears to be independent of the mechanisms of the antipsychotic action.,br,. ...
In the setting of acute myocardial infarction, the evaluation of right ventricular function (RVF), has gained significant attention since the description of the right ventricular infarction (RVI) synd
Acute myocardial infarct (MI), commonly known as a heart attack, is a condition characterized by ischemic injury and necrosis of the cardiac muscle. Ischemic injury occurs when the blood supply is insufficient to meet the tissue demand for metabolism.
The effect of varying both paddle electrode size and the time interval between direct current countershock on myocardial necrosis was studied. Forty-two dogs were divided into seven groups of six dogs each. All dogs were given ten consecutive, 240 watt-second countershocks (delivered energy into a 50 ohm load). Three groups were shocked with paddle electrode diameters of 8.0 cm (standard electrodes), two groups with paddle electrode diameters of 12.8 cm (large electrodes), and two groups with paddle electrode diameters of 4.3 cm (small electrodes). The time intervals between discharges in the groups shocked with the standard electrodes were 15 seconds, one minute, and three minutes. The time interval between discharges in the groups shocked with small and large electrodes was 15 seconds and three minutes. Myocardial necrosis was quantitated by precordial electrocardiographic mapping recorded minutes after, and by gross and microscopic examination of the hearts four days after direct current ...
Pagets disease is a chronic and progressive disorder of bone characterized by focal areas of excessive osteoclastic resorption accompanied by a secondary increase in the osteoblastic activity. Pagets disease of bone (PBD) is a rare endocrine disease especially among Africans and Asians. Hence the detection of a case in a middle-aged Nigerian is of interest. We present the case of a 62-year-old Nigerian man in apparent good health who was found to have a markedly elevated serum total alkaline phosphatase (ALP) of 1179 U/l (reference range, 40-115 U/l) 4 years ago during a routine medical check-up in the USA. He had no history suggestive of PDB and also had no known family history of bone disease. Examination findings were not remarkable except for a relatively large head. A repeat ALP in our centre was 902 U/l (reference range, 40-120 U/l). Cranial CT scan showed diffuse cranial vault thickening consistent with Pagets disease which was confirmed by Tc-99m hydroxymethylene diphosphonate. He was ...
Pagets disease is a chronic and progressive disorder of bone characterized by focal areas of excessive osteoclastic resorption accompanied by a secondary increase in the osteoblastic activity. Pagets disease of bone (PBD) is a rare endocrine disease especially among Africans and Asians. Hence the detection of a case in a middle-aged Nigerian is of interest. We present the case of a 62-year-old Nigerian man in apparent good health who was found to have a markedly elevated serum total alkaline phosphatase (ALP) of 1179 U/l (reference range, 40-115 U/l) 4 years ago during a routine medical check-up in the USA. He had no history suggestive of PDB and also had no known family history of bone disease. Examination findings were not remarkable except for a relatively large head. A repeat ALP in our centre was 902 U/l (reference range, 40-120 U/l). Cranial CT scan showed diffuse cranial vault thickening consistent with Pagets disease which was confirmed by Tc-99m hydroxymethylene diphosphonate. He was ...
Contra-indications for a Dopamine drip include v fib and tachydysrrhythmias because Dopamine will increase the heart rate and can cause dysrrhythmias, so if the patient already has this then it can become worse. Contra-indications for a Nitroglycerine drip include use of erectile dysfunction medications in the last 24 hours, cerebral bleeds, hypotension, bradycardia, or right ventricular infarction. This is because it is a vasodilator so if the patient is already bradycardic or hypotensive they may become more hypotensive, they may bleed more because of the vasodilation allowing more blood flow, and they may lose their preload if they have a right ventricular infarction. Epinephrine may be contra-indicated in patients with hypovolemic shock, coronary insufficiency, or hypersensitivity, however in an emergency setting it is not typically contra-indicated. This is because it is a vasoconstrictor so it can contribute to infarction in the heart if they have coronary insufficiency and in hypovolemic ...
(KudoZ) English to Georgian translation of Myocardial necrosis biomarkers sample: მიოკარდიუმის ნეკროზის ბიომარკერების ნიმუში [Name of a Course - Medical (general) (Medical)].
In two large trials evaluating patients with non-ST-elevation acute coronary syndromes, cardiogenic shock developed 2.5% of patients (91,287). In both the SHOCK registry and GUSTO lib trial, patients developing shock without ST-elevation were older and had more frequent comorbid factors, including more prior infarction, congestive heart failure, and bypass surgery compared to shock patients with ST-elevation (95,287). The onset of shock in the GUSTO-IIb trial was significantly later (76.2 vs 9.6 h, p , 0.001) in patients without ST-elevation (287).. Although mechanical causes of shock are uncommon in this setting, the pathogene-sis of this syndrome is heterogeneous. Compared with ST-elevation infarction, recurrent ischemia and reinfarction are more common. Triple vessel disease is significantly more likely. The left circumflex coronary artery is more frequently identified as the culprit artery (95,287). It is known that total occlusion of the left circumflex artery may occur without ST-elevation ...
Myocardial infarction (MI) or acute myocardial infarction (AMI), commonly known as a heart attack, occurs when blood flow stops to a part of the heart causing damage to the heart muscle. The most common symptom is chest pain or discomfort which may travel into the shoulder, arm, back, neck, or jaw. Often it is in the center or left side of the chest and lasts for more than a few minutes. The discomfort may occasionally feel like heartburn. Other symptoms may include shortness of breath, nausea, feeling faint, a cold sweat, or feeling tired. About 30% of people have atypical symptoms, with women more likely than men to present atypically. Among those over 75 years old, about 5% have had an MI with little or no history of symptoms. An MI may cause heart failure, an irregular heartbeat, or cardiac arrest. ...
Design. Twenty-two piglets (26.7 ± 1.65 kg) were assigned into the interferon group (n = 12) and the control group (n = 10). IR injury was induced by occluding the distal left descending coronary artery (LAD) for 30 minutes. After reperfusion (6 hours), the experiment was terminated. In the interferon group, the animals received 12.5 micrograms of IFN-ß-1a intravenously 8 hours prior to operation, and the dose was repeated right before occlusion of the LAD. In the control group, the animals received saline solution ...
Countershock definition at Dictionary.com, a free online dictionary with pronunciation, synonyms and translation. Look it up now!
Since time immemorial, athletes have always sought to revamp their physical appearance and abilities using steroids. However, most of them have always faced an uphill task choosing the steroid that best suits them due to the vast variety of steroids in the market. This notwithstanding, athletes have now been given their long sought-for remedy in the form of Anadrol 50 steroid.. Anadrol 50 or Adrol, is a trade name for an oral anabolic steroid referred to as Oxymetholone. Having been introduced into the market in the 1960s, Anadrol has gained an inexplicable popularity over the past few decades. This fame can be attributed to its exquisitely crafted chemical composition; its chemical components encompass a Dihydrotestosterone (DHT) which further constitutes a 2-hydroxymethylene group. This chemical composition explains its high anabolic ability…. Moreover, in respect of the chemical structure of Anadrol steroid which encompasses a C17-Alpha Alkaline, Anadrol steroids are administered into the ...
A 57-year-old man developed anginalike chest pain for the first time but there was no objective evidence of an infarct (i.e., EKG and serum enzymes were normal). After 12 days the pain increased, but EKG and serum enzymes remained normal (preinfarct
Expression of JAG2 in mice HMDP. (A) Correlation between JAG2 expression in white adipose tissue (WAT) and body fat mass (%) in HMDP of 86 mice fed a chow diet.