Get an overview of PENTETATE ZINC TRISODIUM (injection, solution, concentrate), including warnings and precautions, directions, and the names of other drugs and products that include the same medication.
Prospective, open-label, multicenter, dose escalation, safety with pharmacokinetics (PK) and dosimetry study of injected Tc 99m tilmanocept in the detection of
It is used as a pharmaceutical intermediates.α-D-Glucose Pentaacetate has been shown to cause an immediate increase in insulin output from rat pancreatic is
Is the Chronic Kidney Disease Epidemiology Collaboration creatinineâ cystatin C equation useful for glomerular filtration rate estimation in the elderly? Xun Liu,1,2,* Huijuan Ma,1,* Hui Huang,3 Cheng Wang,1 Hua Tang,1 Ming Li,1 Yanni Wang,1 Tanqi Lou1 1Division of Nephrology, Department of Internal Medicine, The Third Affiliated Hospital of Sun Yat-sen University, 2College of Biology Engineering, South China University of Technology, 3Department of Cardiology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, Peoples Republic of China*These authors contributed equally to the paperBackground: We aimed to evaluate the performance of the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) creatinineâ cystatin C equation in a cohort of elderly Chinese participants.Materials and methods: Glomerular filtration rate (GFR) was measured in 431 elderly Chinese participants by the technetium-99m diethylene-triamine-penta-acetic acid (99mTc-DTPA) renal dynamic imaging method, and was
R. W. E. Watts, N. Veall, P. Purkiss; Simultaneous Oxalate and 99mTc-DTPA Clearances and Spaces in Primary Hyperoxaluria. Clin Sci (Lond) 1 September 1982; 63 (3): 43P-44P. doi: https://doi.org/10.1042/cs063043Pb. Download citation file:. ...
1. After simultaneous intravenous injection as a mixture, 99mTc-labelled diethylenetriaminepentaacetic acid (99mTc-DTPA; molecular mass 492 Da) and inulin (∼6000 Da) gave arterial plasma clearance curves consisting of three exponentials, the time courses of which were not significantly different between the two solutes.. 2. The ratio of 99mTc-DTPA to inuiin concentration in antecubital venous plasma (normalized to the ratio in arterial plasma at 30 s) was 0.6, significantly less than unity, within 2 min after intravenous injection, but increased to reach unity by 60 min. The minimun concentration ratio of 99mTc-DTPA to inulin in arterial plasma was 0.75 at 4 min, also rising to just above unity at 60 min.. 3. The extraction fraction from plasma to interstitial space was higher for 99mTc-DTPA (∼0.5) than for inuiin (∼0.2). For both solutes, the net extraction fraction decreased with time, becoming negative at about 25 min after injection. Thereafter, the net extraction fractions remained ...
Neuroinflammation has been identified as a potential therapeutic target in amyotrophic lateral sclerosis (ALS), but relevant biomarkers are needed. The superoxide dismutase (SOD1)(G93A) transgenic mouse model of ALS offers a unique opportunity to study and potentially manipulate presymptomatic pathology. While T₂-weighted magnetic resonance imaging (MRI) has been shown to be sensitive to pathologic changes at symptom onset, no earlier biomarkers were previously identified and the underlying histopathologic correlates remain uncertain. To address these issues, we used a multimodal MRI approach targeting structural (T₂, T₁, apparent diffusion coefficient (ADC), magnetization transfer ratio (MTR)), vascular (gadolinium diethylene triamine pentaacetic acid), and endothelial (vascular cell adhesion molecule-microparticles of iron oxide) changes, together with histopathologic analysis from presymptomatic to symptomatic stages of disease. Presymptomatic changes in brainstem nuclei were evident on T₂
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Recent progress in antiretroviral therapy has turned HIV infection into a chronic disease. Patients survival has dramatically improved but complications may occur that need to be prevented and monitored. As much as 10 % of HIV patients may suffer from chronic kidney disease, an affection that is not symptomatic until a very late stage secondary to HIV infection, drugs exposure, hypertension or diabetes. Guidelines have suggested that renal function should be regularly assessed in HIV patients to perform early diagnosis for chronic kidney disease and allow initiation of preventive measures aimed at preserving renal function.. Plasma creatinine dosage is the easiest way to evaluate renal function but glomerular filtration rate estimation from cockcroft or MDRD formulae is a much better indicator of renal function. Other markers like cystatin C may be used. None of these markers has been validated in HIV patients. Therefore our study is aimed at comparing validity of creatinine clearance estimation ...
Recent progress in antiretroviral therapy has turned HIV infection into a chronic disease. Patients survival has dramatically improved but complications may occur that need to be prevented and monitored. As much as 10 % of HIV patients may suffer from chronic kidney disease, an affection that is not symptomatic until a very late stage secondary to HIV infection, drugs exposure, hypertension or diabetes. Guidelines have suggested that renal function should be regularly assessed in HIV patients to perform early diagnosis for chronic kidney disease and allow initiation of preventive measures aimed at preserving renal function.. Plasma creatinine dosage is the easiest way to evaluate renal function but glomerular filtration rate estimation from cockcroft or MDRD formulae is a much better indicator of renal function. Other markers like cystatin C may be used. None of these markers has been validated in HIV patients. Therefore our study is aimed at comparing validity of creatinine clearance estimation ...
Tyramine induces coma in phenelzine-treated dogs with liver disease. The objective of the present investigation was to examine the influence of tyramine in these monoamine oxidase-inhibited dogs on the kinetics of Tc-99m-diethylenetriamine penta-acetic acid (Tc-99m-DTPA) during its first passage through the brain by nuclear imaging techniques. The study began with anesthetized mongrel dogs (n = 10) in a supine position over the camera detector. Data acquisition was started simultaneously after the rapid intracarotid injection of Tc-99m-DTPA (5 mCi) and 60 0.5-sec images of the brain were taken. Tyramine induced increased uptake with a concomitant impairment in the elimination of Tc-99m-DTPA from the brain of these phenelzine-treated animals with hepatic injury (n = 5) as compared to pretreated animals serving as a control group or phenelzine-treated animals without liver disease. This was accompanied by an appreciable reduction in hemispheric cerebral blood flow (50.5 +/- 19.3 vs. 110 +/- 16 ...
Looking for diethylenetriamine? Find out information about diethylenetriamine. 2NH A yellow, hygroscopic liquid with a boiling point of 206.7°C; soluble in water and hydrocarbons; used as a solvent, saponification agent, and fuel component Explanation of diethylenetriamine
diethylenetriamine 111-40-0 NMR spectrum, diethylenetriamine H-NMR spectral analysis, diethylenetriamine C-NMR spectral analysis ect.
4159 Concurrent chemoradiotherapy has been proven efficaciously superior than sequential therapy and is the current standard of care for a number of malignancies, including rectal, head and neck, lung, and esophageal cancers. However, combining chemotherapy and radiotherapy also significantly increases toxicity. Nanoparticle formulations of chemotherapy have been shown to increase efficacy and decrease toxicity when compared to small molecule counterparts. Therefore, we have developed a multifunctional nanoparticle platform for targeted delivery of concurrent chemoradiotherapy. A novel polymer-lipid nanoparticle platform was synthesized by nanoprecipitation of poly (D,L-lactide-co-glycolide) (PLGA) in an aqueous solution containing 1,2-distearoyl-glycero-3-phosphoethanolamine-carboxy polyethylene glycol 2000 (DSPE-PEG), 1,2-dimyristoyl glycero-3-phosphoethanolamine diethylene triamine pentaacetate (DMPE-DTPA) and lecithin. The resulting nanoparticles have a hydrophobic PLGA polymeric core ...
Learn about Ca-DTPA (Pentetate Calcium Trisodium Inj) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and related medications.
A method is described of estimating the malaria incidence rate ĥ and the recovery rate r from longitudinal data. The method is based on the assumption that the phenomenon of patent parasitaemia can be represented by a reversible two-state catalytic model; it is applicable to all problems that can be represented by such a model. ...
Translocation of ultrafine particles (UFP) into the blood that returns from the lungs to the heart has been forwarded as a mechanism for particle-induced cardiovascular effects. The objective of this study was to evaluate the role of the endothelial barrier in the translocation of inhaled UFP from the lung into circulation. The isolated perfused rat lung (IPRL) was used under negative pressure ventilation, and radioactive iridium particles (18 nm, CMD, 192Ir-UFP) were inhaled during 60 minutes to achieve a lung burden of 100 - 200 μg. Particle inhalation was done under following treatments: i) control perfusion, ii) histamine (1 μM in perfusate, iii) luminal histamine instillation (1 mM), and iv) luminal instillation of H2O2. Particle translocation to the perfusate was assessed by the radioactivity of 192Ir isotope. Lung permeability by the use of Tc99m-labeled diethylene triamine pentaacetic acid (DTPA). In addition to light microscopic morphological evaluation of fixed lungs, alkaline phosphatase
Comparison of the Rates of Oxidation of CBZ, 2-OH-CBZ, and 3-OH-CBZ by MPO/H2O2/Cl-. At 25°C, a mixture of CBZ, 2-OH-CBZ, and 3-OH-CBZ (0.05 mM) was incubated with MPO (0.06 unit/150 μl), H2O2 (0.1 mM), and chloride (108 mM) in 150 μl of buffer A (50 mM phosphate buffer and 100 μM diethylenetriamine pentaacetic acid, pH 7.4). In control incubations, MPO was omitted. Samples (20 μl) were taken at 0, 5, 10, 15, 20, and 25 min from the incubation mixture and frozen in dry ice and analyzed with LC/UV/MS/MS (MRM). Five parallel incubations were performed at the same time. Standard curves of these compounds were linear within the concentration range of the measurement.. Incubations of MPO/H2O2/Cl- with 3-OH-CBZ or 4-OH-PHN in the Presence of N-Acetyltyrosine. At 25°C, 3-OH-CBZ or 4-OH-PHN (0.5 mM) was incubated with MPO (0.1 unit/50 μl) and H2O2 (0.25 mM) with or without N-acetyltyrosine (NATyr; 0.5 mM) in 50 μl of total volume in buffer A (50 mM phosphate buffer and 100 μM diethylenetriamine ...
This page includes the following topics and synonyms: Creatinine Clearance, Glomerular Filtration Rate, GFR, CrCl, Cockcroft-Gault, Modification of Diet in Renal Disease, MDRD, Chronic Kidney Disease Epidemiology Collaboration, CKD-EPI.
Tilmanocept is a macromolecule composed of multiple units of diethylenetriaminepentaacetic acid (DTPA) and mannose, each covalently bonded to a 10 kDa backbone of dextran. The DTPA acts as a chelating agent for labelling with Technetium 99m (Tc 99m), while mannose, a naturally occurring sugar, acts as a target ligand. The active component is radioactive Tc 99m, a synthetic element widely used in nuclear medicine that decays with a half-life of 6 hours emitting Gamma-2 photons. The molecular formula of Technetium Tc 99m Tilmanocept is [C6H10O5]n.(C19H28N4O9S99mTc)b.(C13H24N2O5S2)c.(C5H11NS)a. It contains 3-8 conjugated DTPA molecules (b); 12-20 conjugated mannose molecules (c) with 0-17 amine side chains (a) remaining free. The calculated average molecular weight of Tilmanocept ranges from 15,281 to 23,454 g/mol ...
1078715-98-6 - 1,3,5-Triazine-2,4,6-triamine, 2-(2-hydroxyethoxy)ethyl derivs. - Searchable synonyms, formulas, resource links, and other chemical information.
N,N,N-Tris-(tert-butyl)-1,3,5-triazine-2,4,6-triamine/ACM16268987 can be provided in Alfa Chemistry. We are dedicated to provide our customers the best products and services.
70321-65-2 - Amides, from C18-unsatd. fatty acid dimers and diethylenetriamine - Searchable synonyms, formulas, resource links, and other chemical information.
The kinetic identification of chemical reaction systems often represents a time-consuming and complex task. This contribution presents an approach that uses rate estimation and feedback linearization to implement effective control without the use of a kinetic model. The reaction rates are estimated by numerical differentiation of reaction variants that are computed from measurements. The approach is illustrated in simulation through the temperature control of a continuous stirred-tank reactor.. ...
Genetic variation in the response to drug treatment, deteriorating within-host environment and post-treatment recrudescence. (A) Parasite clearance curves for t
In potential living kidney donors, glomerular filtration rate (GFR) is often evaluated from the creatinine clearance (Ccr) or is predicted using formulas based on serum creatinine (SCr) or cystatin C (SCys) concentration. Ultrasonography is used to evaluate renal structure and dimensions. The objective of the present study was to evaluate the possibility of estimation of GFR from echographic renal dimensions in 66 potential live kidney donors (46 women and 20 men; age range, 25-73 years). The GFR was measured as the renal clearance of technetium 99m diethylenetriamine pentaacetic acid. The GFR was also estimated from the SCr concentration using the Cockcroft-Gault (CG-Ccr) and Modification of Diet in Renal Disease (MDRD-GFR) formulas and from SCys (Cys-GFR). Renal diameters were measured using conventional gray-scale renal ultrasound to estimate total and parenchymal renal volume using ellipsoid formulas. The GFR was predicted from renal dimensions on the basis of their relationship to measured ...
Aim This work was performed to study the effect of obestatin on normal, diabetic, and obese male albino rats. Materials and methods A total of 60 male albino rats were divided into six groups: group 1 was the normal control group; group 2, the obestatin-treated group, was injected with 100 μg/kg of obestatin subcutaneously twice daily for 1 week; group 3 was the diabetic control group; group 4, the obestatin-treated diabetic group, was injected with obestatin as in group 2; group 5 was the obese control group; and group 6, the obestatin-treated obese group, was injected with obestatin as in group 2. At the end of the experimental period, serum samples were collected after decapitation for estimation of fasting glucose, insulin, triglyceride (TG), and total cholesterol. BMI was also measured. Results After 1 week of obestatin treatment, the obestatin-treated control group showed insignificant changes in serum fasting glucose, insulin, TG, and total cholesterol levels with the exception of BMI, ...
Early kidney disease is asymptomatic and strongly associated with morbidity and mortality, hence an accurate estimation of kidney function is crucial for its diagnosis. In turn, an appropriate diagnosis and treatment of chronic and acute kidney disease depends on early detection. Currently markers like blood concentrations of creatinine and Cystatin-C are used to estimate glomerular filtration rate, and others as proteinuria help to assess renal damage, but all of these have different limitations indicating the need for new biomarkers that can discriminate and detect damage, especially in the most critical situation during the development of kidney disease. Given that kidneys are the most important excretory organ, changes in blood concentration levels of a wide variety of metabolites can be a reflection of reduction of kidney function and renal damage. An ideal biomarker for renal disease has to be able to predict early diagnosis of kidney disease, allowing for identification of the type and ...
The clinical assessment of the urinary tract generally focuses separately upon (i) identifying the presence of a disease and (ii) evaluating the effects of a disease process upon function of the tract. Thus, renal structure and function must be evaluated separately as they are often not clearly related. Tests performed to detect the presence of structural change affecting the kidneys include urinalysis, imaging studies, and renal biopsy. The impact of a disease process on renal function, however, is generally assessed by tests that evaluate glomerular filtration rate (e.g., measurement of serum concentrations of creatinine and blood urea nitrogen or specialized tests to estimate glomerular filtration rate and renal blood flow), glomerular permselectivity (e.g., measures of proteinuria), and by consideration of renal solute handling and urinary concentrating ability. Evaluating glomerular function: Glomerular filtration rate (GFR) Massive amounts of glomerular filtrate are formed continuously, ...
Page contains details about melamine-based diethylenetriamine dendrimer-functionalized mesoporous SBA-15 . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com
X.Y. Wang, P.Z. Chang, Dejan Vasic, François Costa, Wen-Jong Wu. A Flexion Mode Piezoelectric Micro-Transformer Processed by Aerosol Deposition Method. IEEE IUS 2007, Oct 2007, New-York, United States. ⟨hal-00843674⟩ ...
These are cases from the Renal Scintigraphy section in Nuclear Medicine and PET/CT Cases. The specific content of each case and its diagnosis are necessarily hidden from this abstract. Each case contains case history, followed immediately by the diagnosis, which is supported with findings, differential diagnosis, teaching points, management, and further reading suggestions.
Hyponatremic hypertensive syndrome (HHS) is an uncommon disorder, in which hypertension is associated with profound hyponatremia. It is mostly encountered in adults with unilateral renal artery stenosis. Although renovascular hypertension is one of t
Introduction: Kidney function is an established risk factor for cardiovascular disease (CVD) events [1]. In a high risk CVD population it had been suggested that cystatin C based equations to estimate glomerular filtration rate (eGFR) show better prognostic value than creatinine (Cr) based ones [2]. However, in population-based settings the situation is less clear. In addition it is controversial whether albuminuria carries additional information. The aim of this study was to estimate the association of Cr- and cystatin C-based eGFR and albuminuria with CVD in a population of older adults.. Material & methods: The study included participants, aged 50-75 years, of a statewide cohort study (ESTHER) conducted in the state of Saarland. Stages of chronic kidney disease (CKD) were defined by the Cr based simplified Modification of Diet in Renal Disease (MDRD), the Chronic Kidney Disease Epidemiology (CKD-EPI), and by the cystatin C based Arnal-Dade estimating equations. Active follow-up was conducted ...
BACKGROUND: The standard surgical treatment for slow-transit constipation (STC) is subtotal colectomy and ileorectal anastomosis. A segmental resection may serve the same purpose, but with a reduced risk of side-effects such as diarrhoea or incontinence. The aim of this study was to evaluate the functional results following segmental resection in a consecutive series of patients with STC.. METHODS: Selection criteria included prolonged segmental transit on oral 111In-labelled diethylene triamine penta-acetic acid scintigraphic transit study, and disabling symptoms resistant to medical therapy and treatment of outlet obstruction. Twenty-eight patients (26 women, median age 52 years) were treated with segmental resection and followed prospectively with a validated questionnaire.. RESULTS: After a median of 50 (range 16-78) months, 23 patients were pleased with the outcome. The median (range) stool frequency increased from 1 (0-7) to 7 (0-63) per week (P , 0.001). The number of patients passing ...
OBJECTIVES: Both renal disease and systemic inflammation predict non-AIDS-defining events and overall mortality in HIV-infected patients. Here, we sought to determine the relationships between renal disease and circulating inflammation markers.. METHODS: We performed a secondary analysis of AIDS Clinical Trials Group Study A5224s to determine if markers of renal disease [urine protein:creatinine ratio (uPCR), urine albumin:creatinine ratio (uACR), and estimated glomerular filtration rate (eGFR), using Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) creatinine and cystatin C-creatinine] were associated with markers of systemic inflammation [high-sensitivity C-reactive protein, interleukin-6, tumour necrosis factor (TNF)-α, soluble TNF-α receptor I (sTNFRI), sTNFRII, and soluble vascular cellular and intercellular adhesion molecules]. We correlated these renal and inflammatory markers prior to antiretroviral initiation and after 96 weeks of therapy.. RESULTS: We found that eGFR ...
Adverse impact of bleeding on prognosis in patients with acute coronary syndromes.In persons 30 years or younger, the normal GFR is. estimate glomerular filtration rate from.Normally, healthy people have two kidneys, and their GFR (glomerular filtration rate).Creatinine clearance rates tend to fall later in life as the glomerular filtration rate.Levine GN, Bates ER, Blankenship JC, Bailey SR, Bittl JA, Cercek B, Chambers CE, Ellis SG, Guyton RA, Hollenberg SM, Khot UN, Lange RA, Mauri L, Mehran R, Moussa ID, Mukherjee D, Nallamothu BK, Ting HH Writing Committee Members.The 24-hour urine collection method, or one of the GFR estimation formulas, can more accurately identify the decline in kidney function.RUBY-1: a randomized, double-blind, placebo-controlled trial of the safety and tolerability of the novel oral factor Xa inhibitor darexaban (YM150) following acute coronary syndrome.However, the risk-to-benefit ratio with antithrombotic therapies may be altered in CKD.. Impact of proteinuria and ...
Reference: Gordon B.G., Veselkin N.V., Intoxication of the central nervous system in hepatic functional disorders, Voprosy meditsinskoi khimii, 1956, vol: 2(5), 350-356 ...
A medical imaging procedure known as lung scintigraphy may be more reliable than pulmonary CT angiography (CTA) for identifying or excluding pulmonary embolism (PE) in pregnant patients, according to a study published in ...
Objective: Compressive sensing (CS) has recently been applied as a low-complexity compression framework for long-term monitoring of electrocardiogram (ECG)
Page 388 378 ENZYME SYSTEMS THAT METABOLISE Farmacocinetia AND OTHER XENOBIOTICS 1995; Dufort et al. Background correction is propranolol farmacocinetica farmacodinamia since about 30 of the activity in the left ventricle is contributed by noncardiac structures.
The aim of this study was to determine whether the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI)- or Cockcroft-Gault (CG)-based estimated glomerular filtration rates (eGFRs) performs better in the cohort setting for predicting moderate/advanced chronic kidney disease (CKD) or end-stage renal disease (ESRD ...
Endothelial dysfunction is considered an early step of atherosclerotic vascular disease. Asymmetric dimethylarginine (ADMA), the main endogenous inhibitor of nitric oxide synthase (NOS), plays a critical role in the process of atherosclerosis in a uremic environment. Increased plasma ADMA not only works as a cardiovascular morbidity biomarker but it is also involved in the genesis of atherosclerosis in renal disease. Considering the relationships of apolipoprotein E(ApoE) polymorphism with LDL cholesterol (LDL-C) levels and coronary risk, it is possible that it brings on susceptibility to endothelial dysfunction and atherogenesis seen on uremia. Six hundred twenty patients were stratified according to glomerular filtration rate (GFR) estimated by Chronic Kidney Disease Epidemiology Collaboration (CKDEPI) formula: group I | 60 mL/min, group II ≤ 60 mL/min and | 15 mL/min, and group III ≤ 15 mL/min or in hemodialysis. Polymorphic ApoE analysis was performed by polymerase chain reaction amplification
Serum creatinine is measured to assess for the presence of kidney disease, which can be either the cause or the result of hypertension. Serum creatinine alone may overestimate glomerular filtration rate and recent guidelines advocate the use of predictive equations such as the Modification of Diet in Renal Disease (MDRD) formula to estimate glomerular filtration rate (eGFR).[27] eGFR can also provide a baseline measurement of kidney function that can be used to monitor for side effects of certain anti-hypertensive drugs on kidney function. Additionally, testing of urine samples for protein is used as a secondary indicator of kidney disease. Electrocardiogram (EKG/ECG) testing is done to check for evidence that the heart is under strain from high blood pressure. It may also show whether there is thickening of the heart muscle (left ventricular hypertrophy) or whether the heart has experienced a prior minor disturbance such as a silent heart attack. A chest X-ray or an echocardiogram may also be ...
The renal and systemic changes after stenosis of the left renal artery (n = 5) or sham stenosis (n = 6) in conscious dogs were studied sequentially over 25 days. Stenosis produced a prompt rise in arterial pressure, which was at all times due to reduced peripheral vascular conductance, with no increase in cardiac output despite initial evidence of mild fluid retention. The decrease in peripheral conductance was attributable to 1) the stenotic kidney (25% of the total and due to the mechanical effect of the stenosis itself), 2) the nonstenotic kidney (about 15% of the total and not caused by angiotensin II), and 3) the nonrenal vasculature (60%). The decrease in conductance in the nonrenal vasculature was due partly to angiotensin II, but there was also a gradually developing non-angiotensin II component. Acute administration of captopril caused significantly greater changes in arterial pressure and peripheral conductance throughout the period of stenosis than before stenosis (and greater than in ...
© 2015 Taylor & Francis. Accurate assessment of a childs health is critical for appropriate allocation of medical resources and timely delivery of healthcare in Emergency Departments. The accurate measurement of vital signs is a key step in the determination of the severity of illness and respiratory rate is currently the most difficult vital sign to measure accurately. Several previous studies have attempted to extract respiratory rate from photoplethysmogram (PPG) recordings. However, the majority have been conducted in controlled settings using PPG recordings from healthy subjects. In many studies, manual selection of clean sections of PPG recordings was undertaken before assessing the accuracy of the signal processing algorithms developed. Such selection procedures are not appropriate in clinical settings. A major limitation of AR modelling, previously applied to respiratory rate estimation, is an appropriate selection of model order. This study developed a novel algorithm that automatically
A novel affinity system for a two-phase delivery of radionuclides to tumor cells has been developed. In the first phase, a nontoxic bivalent monoclonal antibody conjugated to an enzyme is targeted to the tumor cells. In the second phase, a radionuclide-derivatized enzyme inhibitor, specific for the enzyme conjugated to the antibody, is administered. The model system selected for this study is the recombinant human enzyme dihydrofolate reductase (rhDHFR) and its high-affinity competitive inhibitor methotrexate (MTX). MTX was labeled with a radionuclide by covalent attachment of diethylenetriaminepentaacetic acid (DTPA) complexed with 111In. Using the γ-carboxyl residue of MTX for the attachment of DTPA, binding of the inhibitor to rhDHFR was not affected. The inhibitory activities of nonderivatized MTX and DTPA-MTX were indistinguishable. Human K562 erythroleukemia cells were used to evaluate under in vitro conditions the DHFR-MTX affinity system for the delivery of 111In-labeled DTPA-MTX to ...
Breast-feeding There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Other medicines Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine. Other interactions Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. Other medical problems The ...
Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Institutionen för medicin och vård, Medicinsk radiofysik. Östergötlands Läns Landsting, Kirurgi- och onkologicentrum, Radiofysikavdelningen. ...