Technetium Tc 99m Dimercaptosuccinic Acid: A nontoxic radiopharmaceutical that is used in the diagnostic imaging of the renal cortex.
TY - JOUR. T1 - The role of procalcitonin for acute pyelonephritis and subsequent renal scarring in infants and young children. AU - Sheu, Ji Nan. AU - Chang, Hung Ming. AU - Chen, Shan Ming. AU - Hung, Tung Wei. AU - Lue, Ko Huang. PY - 2011/11. Y1 - 2011/11. N2 - Purpose: We assessed the usefulness of procalcitonin as a biological marker in diagnosing acute pyelonephritis and for predicting subsequent renal scarring in young children with a first febrile urinary tract infection. Materials and Methods: Children 2 years old or younger with a first febrile urinary tract infection were prospectively studied. Renal parenchymal involvement was assessed by 99mTc-dimercaptosuccinic acid scan within 5 days of admission and after 6 months. Serum samples from all patients were tested for procalcitonin, C-reactive protein and white blood cell count measurements. Results: The 112 enrolled patients (age range 24 days to 24 months old) were divided into acute pyelonephritis (76) and lower urinary tract ...
TY - JOUR. T1 - Urinary Cytokines and Renal Doppler Study in Kawasaki Disease. AU - Wu, Jing-Ming. AU - Chiou, Yuan-Yow. AU - Hung, Wen Pin. AU - Chiu, Nan-Tsing. AU - Chen, Mei Ju. AU - Wang, Jieh-Neng. PY - 2010/5/1. Y1 - 2010/5/1. N2 - Objective: To investigate whether renal vasculitis is the sole cause or merely a contributing cause of renal inflammation in Kawasaki disease (KD). Study design: This prospective study in a university medical center in Taiwan enrolled 24 children with KD between June 2004 and November 2005. All patients underwent a technetium-99 m dimercaptosuccinic acid scintigraphy single-photon emission computed tomography scan, the results of which were used to group the patients with KD as with or without renal involvement. Urine samples underwent a cytokine analysis. Renal Doppler ultrasonography was used to evaluate renal vasculitis by measuring the pulsatility index (PI) and resistance index (RI). Results: Ten of the 24 patients (42%) with renal inflammatory foci were ...
A DMSA scan is a radionuclide scan that uses dimercaptosuccinic acid (DMSA) in assessing renal morphology, structure and function. Radioactive technetium-99m is combined with DMSA and injected into a patient, followed by imaging with a gamma camera. A DMSA scan is usually static, other radiotracers are usually used with dynamic imaging to assess renal function. The major clinical indications for this investigation are the detection and/or evaluation of a renal scar, the small or absent kidney (renal agenesis), an occult duplex system, certain renal masses, systemic hypertension or suspected vasculitis. It is sometimes used as a test for the diagnosis of acute pyelonephritis. However, the sensitivity of DMSA scan for acute pyelonephritis may be as low as 46%. "Renal Cortical Scintigraphy (DMSA scan) Clinical Guidelines" (PDF). BNMS. 2011. Retrieved 11 June 2017. Fogelman, Ignac; Clarke, Susan; Cook, Gary; Gnanasegaran, Gopinath (2014). Atlas of Clinical Nuclear Medicine, Third Edition. CRC Press. ...
The optimal regimen for investigating children with urinary tract infection (UTI) remains uncertain. Ultrasonography, contrast micturating cystourethrography (MCU), intravenous urography (IVU), and technetium-99m dimercaptosuccinic acid (DMSA) studies were performed in 58 children with UTI under 14 years of age attending two teaching hospitals and the results compared. All four investigations were normal in 12 children. In 36 with vesicoureteric reflux (VUR) on MCU, dilatation was reported on ultrasonography in eight children. Radiological renal scarring was seen in 20 children; it was suspected on ultrasonography in nine, with dilatation alone in four, and a normal report in seven. Duplex kidneys identified on IVU were unrecognised on ultrasonography or DMSA studies; ultrasonography showed no change corresponding to presumed acute defects on DMSA studies that later resolved. Disparities were observed at all ages. This study suggests that ultrasonography is unreliable in detecting VUR, renal ...
TY - JOUR. T1 - Tc-99m DMSA uptake by metastatic carcinoma of the prostate. AU - Lamki, L.. AU - Shearer, R.. PY - 1984. Y1 - 1984. UR - http://www.scopus.com/inward/record.url?scp=0021250193&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0021250193&partnerID=8YFLogxK. M3 - Letter. C2 - 6327947. AN - SCOPUS:0021250193. VL - 25. SP - 733. EP - 734. JO - Journal of Nuclear Medicine. JF - Journal of Nuclear Medicine. SN - 0161-5505. IS - 6. ER - ...
Fibrous cortical defect (FCD) also known as non-ossifying fibroma (NOF) is the most frequent bone lesion in children, occurring in up to 30-40% of children. It is most commonly seen in adolescents. No histologic difference exists between non-os...
DMSA, or dimercaptosuccinic acid, is a radioactive substance (called a radiopharmaceutical) that is injected into a vein and enters the kidneys. The gamma rays that are emitted from the radiopharmaceutical are detected by gamma cameras and enables a picture to be taken of the inside of the kidneys.
Denoyer, Delphine, Perek, Nathalie, Le Jeune, Nathalie, Frere, Delphine and Dubois, Francis 2004, Evidence that 99mTc-(V)-DMSA uptake is mediated by NaPi cotransporter type III in tumour cell lines, European journal of nuclear medicine and molecular imaging, vol. 31, no. 1, pp. 77-84, doi: 10.1007/s00259-003-1334-7. ...
Designing a system for computer aided diagnosis is a complex procedure requiring an understanding of the biology of the disease, insight into hospital workflow and awareness of available technical solutions. This paper aims to show that a valuable system can be designed for diagnosing kidney lesions in children and adolescents from 99mTc- DMSA scintigraphy images. We present the chain of analysis and provide a discussion of its performance. On a per-lesion basis, the classification reached an ROC-curve area of 0.96 (sensitivity/specificity e.g. 97%/85%) measured using an independent test group consisting of 56 patients with 730 candidate lesions. We conclude that the presented system for diagnostic support has the potential of increasing the quality of care regarding this type of examination ...
Junctional parenchymal defects in renal imaging are a normal variant. Pathology It results from the incomplete embryonic fusion of renunculi. Radiographic features Ultrasound It can be seen as a triangular echogenic cortical defect, frequent...
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... Information for Physicians. AnazaoHealth, Nuclear Medicine Division, can precisely compound Sn-Dimercaptosuccinic Acid freeze-dried kits on your order. We can ship to you overnight.. AnazaoHealth has been compounding Sn-Dimercaptosuccinic Acid Kits for the Preparation of TC-99m-DMSA on prescription.. Please contact AnazaoHealth for information about these products.. ...
... Information for Physicians. AnazaoHealth, Nuclear Medicine Division, can precisely compound Sn-Dimercaptosuccinic Acid freeze-dried kits on your order. We can ship to you overnight.. AnazaoHealth has been compounding Sn-Dimercaptosuccinic Acid Kits for the Preparation of TC-99m-DMSA on prescription.. Please contact AnazaoHealth for information about these products.. ...
Methods for treatment of humans and other animals with dimercaptosuccinic acid (DMSA). DMSA is administered to reduce levels of silicon in blood and tissue, reduce blood pressure, improve kidney function, prevent or retard the progression of chronic renal failure, treat the accumulation of silicon in advanced kidney disease, decrease accumulation of reactive oxygen metabolites, increase superoxide dismutase activity, and/or prevent the onset or improve the current status of senile dementia or Alzheimers disease.
Aim: The aim of this study was to investigate risk factors associated with different extents of renal parenchyma involvement in a paediatric series of primary vesicoureteral reflux (VUR).. Methods: A total of 549 patients with VUR were analyzed. The variable of interest was renal scar, assessed by technetium-99m dimercaptosuccinic acid scan, and classified into three subtypes: focal scar, multiple cortical scarring and diffuse scars with a contracted renal unit. The multinomial regression model was applied to identify independent variables associated with each subtype of renal damage.. Results: After adjustment, four variables remained independently associated with a contracted renal unit: reflux grades III-V (odds ratio (OR) = 9.7; 95% confidence interval (CI) = 4.1-21.0), age at diagnosis (OR = 3; 95% CI = 1.6-5.1), unilateral reflux (OR = 2.1; 95% CI = 1.2-3.8), and male sex (OR = 2; 95% CI = 1.1-3.8). Two variables were associated with multiple scars: reflux grades III-V (OR = 13.8; 95% CI = ...
Magnetic nanoparticles surface-covered with meso-2,3-dimercaptosuccinic acid (MNPs-DMSA) constitute a promising approach for tissue- and cell-targeted delivery of therapeutic drugs in the lung. However, they can also induce a transient transendothelial migration of leukocytes in the organ as a side effect after endovenous administration of MNPs-DMSA. We demonstrated that monocytes/macrophages constitute ...
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Sven Meier resolved WICKET-6255. -------------------------------- Resolution: Not A Problem Assignee: Sven Meier Please read Palettes Javadoc: you have to add the behavior to the recorder component. , Palette cannot use Ajax Behavior , -------------------------------- , , Key: WICKET-6255 , URL: https://issues.apache.org/jira/browse/WICKET-6255 , Project: Wicket , Issue Type: Bug , Components: wicket-extensions , Affects Versions: 7.4.0 , Environment: JAVA 1.8 , Reporter: Jakob , Assignee: Sven Meier , Labels: Palette , Attachments: code_shot.png, log_shot.png, page_shot.png , , , I have define a Palette, I want to listen the behavior change selector. , so i add a ajax behavior AjaxFormComponentUpdatingBehavior. , however I cannot get the selectedList value in the ajax override function , onUpdate(); , the function is triggered but the selectedList.size() is always 0. , attachements are code page and log screenshot. -- This message was sent by Atlassian JIRA (v6.3.4#6332 ...
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A high dose and continuous infusion of cefoxitin has been associated with clinical success in treating febrile urinary tract infections (UTIs) in men...
Chelation challenge testing has been used to assess the body burden of various metals. The best-known example is EDTA challenge in lead-exposed individuals. This study assessed diagnostic chelation challenge with dimercaptosuccinic acid (DMSA) as a measure of mercury body burden among mercury-expose …
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To our knowledge, this is the first assessment of 99mTc-DPD scintigraphy as a potential diagnostic tool for assessment of etiology in cardiac amyloidosis. Our findings could have potential clinical implications (especially in the light of recent therapeutic advances), and they also could help clarify the conflicting data in published reports on the use of bone tracers in the scintigraphic evaluation of amyloidosis.. Noninvasive detection of amyloid has been investigated using three main groups of radiolabeled tracers: 123I-labeled serum amyloid P protein (26,27); aprotinin (28,29); and bone tracers, mainly 99mTc-pyrophosphate (9-15) and 99mTc-HDP (20,21). Labeled serum amyloid P protein localizes rapidly and specifically to amyloid deposits (in proportion to the amount of amyloid) and persists there, allowing quantitative monitoring of amyloid deposition and regression during therapy (low quality of heart visualization and limited availability are current limitations of this tracer [12,13]). ...
Because host inflammatory response is the final and most important step in the formation of renal scars, the use of anti-inflammatory agents may be the best strategy to reduce renal scarring. In animal studies, the use of corticosteroids has been shown to be effective in preventing post-pyelonephritic scarring. We will conduct a randomized, double-blind, placebo-controlled trial to determine the efficacy of 3 days of daily adjuvant dexamethasone on the incidence of renal scarring 4 to 6 months after a first febrile UTI. We hypothesize that the proportion of children with UTI who develop renal scarring will be lower among children who are treated with both dexamethasone and antibiotics as compared with children treated with antibiotics alone ...