The number of Asialoglycoprotein (ASGP) receptors on the hepatocytes of patients with liver disease is reduced and is thus considered a good indicator for the evaluation of liver function. ASGP receptor-targeted radiopharmaceuticals permit a non-invasive way to evaluate total and regional hepatic function and hepatic functional reserve visually and quantitatively. Over the past three decades, a variety of ASGP receptor-targeted probes have been developed with different molecular backbones (albumin, polymer, small-molecular-weight ligand), different glycol-residues (galactose, lactose, N-acetyl-galactosamine) and different chelating systems suitable for radiolabeling with SPECT isotopes (Tc-99m, In-111, Ga-67, (131)/I-125, Sm-153) and PET isotopes (Ga-68, F-18). In this review, we present an overview of ASGP receptor-targeted radiopharmaceuticals, discuss their chemistry, biodistribution, catabolism and challenge as well as application for measurement of liver function ...
Technetium Tc 99m apcitide is indicated for scintigraphic imaging of acute venous thrombosis in the lower extremities in patients with signs and symptoms of acute blood clots
A Multi-Center Clinical Study to Evaluate the Safety and Efficacy of FolateScan (Technetium Tc 99m EC20) in Women with Suspected Ovarian or Endometrial
technetium Tc 99 5,10,15,20-tetrakis (4-(4,8,11-tris(carboxymethyl)-1-(1,4,8,11-tetraazacyclotetradecane)amidomethyleneoxy)phenyl) ...
Decreased plasma motilin concentrations in pregnancy.: Plasma motilin concentrations were measured in 37 women during the second and third trimester of pregnanc
Comprehensive information for the element Technetium - Tc is provided by this page including scores of properties, element names in many languages, most known nuclides and technical terms are linked to their definitions.
This project is supported in part by the NIH Specialized Programs of Translational Research in Acute Stroke (SPOTRIAS) Network, and NINDS grant 3P50NS055977 to Washington University in St. Louis School of Medicine and UT Southwestern Medical Center.. ...
If 1,2,3-Triazoles are well known for their biological properties, particular attention has been recently devoted to the development of 2-pyridyl-1,2,3-triazole derivatives (or pyta) as alternative ligands to 2,2-bipyridines. This interest is explained by the easy preparation of such ligands using a click chemistry strategy (Obata et al., 2008; Schweinfurth et al., 2008), and the use of pyta derivatives as efficient chelator systems for Tc(CO)3+ or Re(CO)3+ organometallic cores (Boulay et al., 2010; Seridi et al., 2011). Recently, structural pyta isomers like 4-pyridyl-1,2,3-triazole have been described as building blocks in the synthesis of chelating agents for biomedical applications (Bonnet et al., 2012; Pellegatti et al., 2008). In this paper, we report on the first X-ray structure analysis of a 4-pyridyl-1,2,3-triazole derivative.. The title molecule, Fig. 1, can be considered as a ditopic ligand with two distinct transition metal complexing sites, the iminodiacetate (IDA) pincer and the ...
Novel 3-O-1,2;5,6-di-O-isopropylidene-alpha-D-glueofuranose] and 3-O-D-glucose] derivatives with an iminodiacetate (N,O,O), a histidinate, and an N-(acetetyl)picolylamine (N,N,O) chelating system for tridentate coordination of the organometallic M(CO)(3)-fragment (M = Tc, Re) have been prepared. The chelates were introduced and assembled through reductive amination starting from 3-O-1,2;5,6-di-O-isopropylidene-alpha-D-glucofuranose]-acetaldehyde. After deprotection, the pyranose derivatives were reacted with the precursor NEt4](2)ReBr3(CO)(3)] to afford the corresponding organometallic complexes in yields between 54% and 94%. The NMR, MS, and IR analyses corroborated the tridentate coordination of the organometallic metal center exclusively via the synthetic chelates. In the case of the N-(acetyl)picolylamine derivative, the coordinative properties were further confirmed by X-ray structure analysis of the first Re(CO)(3)-D-glucofuranose complex. All glucose complexes unveiled good stability and ...
Technetium Tc 99m Pyrophosphate: A radionuclide imaging agent used primarily in scintigraphy or tomography of the heart to evaluate the extent of the necrotic myocardial process. It has also been used in noninvasive tests for the distribution of organ involvement in different types of amyloidosis and for the evaluation of muscle necrosis in the extremities.
KIT FOR THE PREPARATION OF TECHNETIUM TC99M DISOFENIN - disofenin injection, powder, lyophilized, for solution - Prescription (RX) Marketed Drugs Encyclopedia
Albireo is developing A3384 to treat bile acid malabsorption disease (BAM), which has no approved treatment options. Learn about the clinical trial and more.
Hi, Ive had a small goiter that I first noticed 10 years ago. At that time, I had an ultrasound and a FNB which was negative for cancer. My latest blood tests are normal and the goiter doesnt look t...
Journal: EJNMMI Research ArticleTitle: Hepatobiliary scintigraphy may improve radioembolization treatment planning in HCC patients
Medical definition of enterogastric reflex: reflex inhibition of the emptying of the stomachs contents through the pylorus that occurs when the…
A new study in The American Journal of Pathology reports on a promising new approach to prevent and treat cholesterol gallstone disease (CGD) that reduces the biliary output of cholesterol via activation of receptors present in tissues of the liver and small intestine.
Recent advances in imaging techniques have determined a radical change in the radiological approach to the diagnosis and treatment of hepatobiliary, pancreatic, and.Diagnostic imaging of the hepatobiliary system in infants and children.Diagnostic Imaging of the Hepatobiliary System An Update Angela J.Applied hepatobiliary scintigraphy in. multiple imaging tests are used in what often. while displaying the least activity outside the hepatobiliary system.Gastrointestinal and Hepatobiliary Imaging PIONEERS OF AIIMS-MAMC-PGI IMAGING COURSE SERIES Manorama Berry Sudha Suri.. Imaging is a big part of the workup for evaluating liver cancer ...
TY - JOUR. T1 - Remission of bile acid malabsorption symptoms following treatment with the glucagon-like peptide 1 receptor agonist liraglutide. AU - Kårhus, Martin L. AU - Brønden, Andreas. AU - Røder, Michael E. AU - Leotta, Salvatore. AU - Sonne, David P. AU - Knop, Filip K. PY - 2019/8/1. Y1 - 2019/8/1. KW - Aged. KW - Bile Acids and Salts/metabolism. KW - Diabetes Mellitus, Type 2/complications. KW - Female. KW - Glucagon-Like Peptide-1 Receptor/antagonists & inhibitors. KW - Humans. KW - Liraglutide/pharmacology. KW - Malabsorption Syndromes/drug therapy. KW - Male. KW - Middle Aged. KW - Overweight/complications. KW - Remission Induction/methods. KW - Treatment Outcome. UR - http://www.scopus.com/inward/record.url?scp=85069552243&partnerID=8YFLogxK. U2 - 10.1053/j.gastro.2019.04.002. DO - 10.1053/j.gastro.2019.04.002. M3 - Journal article. VL - 157. SP - 569. EP - 571. JO - Gastroenterology. JF - Gastroenterology. SN - 0016-5085. IS - 2. ER - ...
Aliment Pharmacol Ther. 2009 Oct;30(7):707-17. doi: 10.1111/j.1365-2036.2009.04081.x. Epub 2009 Jun 30. Research Support, Non-U.S. Govt; Review