Clinical studies suggest that chorda-sparing mitral valve replacement techniques are associated with superior postoperative outcome, and several animal experiments have shown that disruption of the mitral subvalvular apparatus is followed by deterioration of left ventricular systolic function. One essential element, however, underlying the importance of chordal integrity for left ventricular function remains unproved: All investigators heretofore have been unable to demonstrate that left ventricular systolic performance can be restored by chordal reattachment after disruption of annular-papillary continuity. Therefore, we studied the effects of chordal detachment and subsequent chordal reattachment on left ventricular systolic performance using an in situ, isovolumic heart preparation in 10 halothane-anesthetized swine. The slope and left ventricular volume intercept of the isovolumic peak pressure-volume relationship were measured to assess global left ventricular systolic performance ...
Preoperative Systolic Strain Rate Predicts Postoperative Left Ventricular Systolic Function in Patients With Chronic Mitral Regurgitation: 18 Months Follow up ...
Assessment of left ventricular (LV) systolic function is important for diagnosis, management, follow-up, and prognostic evaluation of patients in a variety of clinical settings. Accurate and reliable determination of LV systolic function is important
Background: Left ventricular (LV) myocardial strain and strain rate (SR) both depend upon afterload. However, the difference in the afterload dependency between these 2 indices has not been investigated.. Methods: Echocardiography was performed in 41 healthy volunteers before and during handgrip exercise. The handgrip exercise was performed at 50% of the maximum grasping power for 4 minutes. Meridional wall stress (MWS) was calculated from end-systolic LV dimension and wall thickness as well as systolic blood pressure. By using speckle tracking echocardiography, longitudinal peak strain (LS) and systolic peak SR (LSR) were measured and averaged in 3 apical views. These parameters were indicated in the absolute values.. Results: During handgrip exercise, systolic blood pressure increased from 98±11 to 116±15 mmHg and MWS increased from 660±130 to 975±174 dyn•mm-2 (%change: 49±18%). In response to this increase in MWS, LS decreased by 8.4±4.8% (from 17.2±1.7 to 15.7±1.4%). In comparison, ...
Overview Normal LV contraction Global & regional indices of LV systolic Function Angiographic assessments Echocardiography MRI Computed Tomography Nuclear Imaging Take home message
I recently had an echocardiogram to rule out infrequent weakness in both arms as being heart related. The report came back: normal chambers, normal left ventricular systolic function, EF 60-65%, norm...
RESULTS: There were 43 males (78.2%) and 12 females (21.8%). The mean age was 52.3±16.7 years (range: 15.5-76.4 years). A significant difference of GFI was found for preserved versus impaired systolic function of the left ventricle (preserved systolic function); GFI-M 2.28±0.60 versus 3.66±0.50 (p,0.001), and GFI-I 2.75±0.88 versus 3.81±0.87 (p,0.001), respectively. Diagnostic value was tested using receiver operating curve (ROC) analyzes, with GFI-M area under curve (AUC)=0.959 (95% CI: 0.868-0.994); (p,0.001) and GFI-I-AUC=0.847 (0.724-0.930); (p,0.001). GFI-M was superior to GFI-I for appraisal of left ventricle systolic dysfunction in HCM; ΔAUC=0.112 (0.018-0.207); (p=0.020 ...
Systo*le (?), n. [NL., fr. Gr. &?;, fr. &?; to contract; sy`n with + &?; to set, place.] 1. (Gram.) The shortening of ...
... : systemizer, systemizes, systemizing, systemless, systems, systemwide, systole, systoles, systolic, systyle, sythe, syver, syzygal, syzygetic, syzygial, syzygies, syzygy...
TY - JOUR. T1 - Systolic time ratio by impedance cardiography to distinguish preserved vs impaired left ventricular systolic function in heart failure. AU - Thompson, Brenda. AU - Drazner, Mark H.. AU - Dries, Daniel L.. AU - Yancy, Clyde W.. PY - 2008/12/1. Y1 - 2008/12/1. N2 - Left ventricular ejection fraction (EF) is used to assess patients with heart failure (HF); however, frequent measurements are not cost-effective. Impedance cardiography (ICG) is a low-cost, noninvasive test that measures systolic time intervals and may be a method for detecting impaired vs intact EF. This study evaluated the relationship between EF by echocardiography or gated nuclear ventriculography and systolic time ratio (STR) by ICG in outpatients with chronic HF. A retrospective chart review identified 52 patients with EF and STR measured within 2 weeks. There was an inverse correlation between STR and EF (r=)0.54; P,.001). The area under the receiver operating characteristic curve for STR to identify reduced EF ...
Quantification of ventricular pump function is fundamental to the practice of cardiology and is required for research into most aspects of cardiac physiology, disease, and therapeutics. Drawing an analogy between the heart and a steam engine, Otto Frank (1) introduced the pressure-volume diagram as a means of characterizing left ventricular properties in the 1890s. Nearly 80 years later, Suga (2) formalized the idea that the relationship between pressure and volume at end systole was relatively independent of loading conditions and that the slope of the curve, called Emax or Ees, was a sensitive measure of contractility. At nearly the same time, several investigators demonstrated how the relationship between pressure and volume at end diastole similarly provided the framework for quantifying passive properties of the myocardium (3,4). In the decades to follow, there was intensive research into the characteristics of the end-systolic pressure-volume relation (ESPVR) and end-diastolic ...
The SCG signal is measured by placing an accelerometer on the torso which captures the induced vibration of the heart propagated to the surface of the chest. The feasibility of using seismocardiogram (SCG), in conjunction with ECG, for finding cardiac time intervals was first investigated in 1990s and has also been recently verified. Specific peaks of the SCG signal correspond to different events of the cardiac cycle (Fig. 1).. Systolic time intervals (STI) are important parameters that have been used for quantification of the performance of the heart and include the electro-mechanical systole, left ventricular ejection time (LVET), pre-ejection period (PEP) and isovolumetric-contraction. These parameters can be extracted from SCG as can be seen in the modified Wiggers diagram (Fig 1 ...
GE: Chest radiograph was normal with no cardiomegaly and normal lung fields. Spirometry was normal (forced expiratory volume in the first second 2.9L, 95% predicted; forced vital capacity 3.6L, 91%; maximal expiratory flow 50 130%). There was poor R wave progression on ECG and an echocardiogram showed left ventricular hypertrophy with an estimated pulmonary artery systolic pressure of 44 mm Hg+right atrial pressure. Left ventricular systolic function was reported as good. He achieved 525 m on a 6-min walk with no desaturation on oximetry but he experienced significant breathlessness. A CT scan of the thorax demonstrated normal lungs with no evidence of interstitial or small airways disease and no pulmonary emboli. He scored 50/70 on the Hull Airway Reflux Questionnaire (HARQ).1 An airway pH study and barium swallow confirmed the presence of reflux.. AHM: The cardiac investigations are abnormal, but the reported good left ventricular systolic function suggests simple pump failure is unlikely. A ...
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OBJECTIVE To complement the ISO 5840 standards concerning the duration of left ventricular systole and diastole as a function of changes in heart rates according to in vivo studies from the physiologic literature review. METHODS The systolic and diastolic durations from three in vivo studies were compared with the durations of systole proposed by the ISO 5840:2010 and ISO 5840-2:2015 for hydrodynamic performance assessment of prosthetic heart valves. RESULTS Based on the in vivo studies analyzed, the systolic durations proposed by the ISO 5840 standard seemed consistent for 45 and 120 beats per minute (bpm), and showed diverse results for the 70 bpm condition. CONCLUSION Information on the realistic validation of the operation of left ventricular models for different heart rates were obtained.
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In this study we will investigate a method combining transoesophageal echocardiography and non-invasive finger arterial blood pressure waveforms to non-invasively construct pressure-volume (P-V) loops to describe the end-systolic pressure-volume relations in the heart. This may provide a method to obtain more insight on cardiac contractile function and the interaction of the heart with the vasculature during surgery ...
Background: Speckle tracking echocardiography (STE) provides novel insight into both global and regional systolic and diastolic function. There are both vendor-dependent (2D strain-GE Healthcare-2DS) and vendor-independent (Cardiac Performance Analysis-CPA-TomTec Imaging Systems-VVI) analysis algorithms that are available. Accordingly our aim was (1) to establish reference values for strain (ε) and systolic synchrony and (2) to determine whether the two different STE methods provide similar data.. Methods: 27 consecutive normal subjects were studied (average age 47 years, 72% female). DICOM data were analyzed with EchoPac (GE) and CPA (TomTec) software, offline. The peak principal strains, longitudinal (εl), circumferential (εc), and radial (εr) were derived by both 2DS and VVI STE. We also computed time to peak maximal ε (TPkε) for all ε values, and between corresponding wall segments.. Results: (see Table)ε values obtained by VVI were comparable to those obtained by 2DS for εl and ...
Systolic hypertension in the elderly is a common clinical problem which represents a major therapeutic dilemma. The magnitude of the problem is increasing as the population of individuals over 50...
Isolated systolic hypertension information including symptoms, diagnosis, misdiagnosis, treatment, causes, patient stories, videos, forums, prevention, and prognosis.
Answer The tie is between B and D We know in hypertensive hearts LV primarily fails in diastole . Lungs get congested due to raised LVEDP .Here is a catch . . . if diastole is terribly dysfunctional how can be systole be near normal ? (After all . . . systole is not…
We show that for closed orientable manifolds the k-dimensional stable systole admits a metric-independent volume bound if and only if there are cohomology classes of degree k that generate cohomology in top-degree. Moreover, it turns out that in the nonorientable case such a bound does not exist for stable systoles of dimension at least two. Additionally, we prove that the stable systolic constant depends only on the image of the fundamental class in a suitable Eilenberg-MacLane space. Consequently, the stable k-systolic constant is completely determined by the multilinear intersection form on k-dimensional cohomology.
Gabacap: dr. ellwood. now maybe when you are in a medicare age group. gabacap 100mg force during the systole and thus the work is increased beyond the
Results Conventional echocardiographic measurements (LV end diastolic diameter, LV end systolic diameter and LV EF) were similar between the groups. Longitudinal peak systolic strain (13.20±3.5% to 20.97±4.5%, p=0.0001) and strain rate (0.23±0.18 1/s to 4.92±0.55 1/s, p=0.0001) of the LV were significantly impaired in patients with TA, compared to controls, demonstrating subclinical ventricular systolic dysfunction. Supporting these results, we revealed impaired subclinical LV systolic function in patients with SLE, when compared to the control group (14±4.53% to 20.97±4.5%, p=0.0001 for strain; 0.23±0.12 1/s to 4.92±0.55 1/s, p=0.0001 for strain rate). The mean disease duration of the patient was 5.6 years in patients with TA. The LV systolic dysfunction was negatively correlated with disease duration, but this correlation couldnt reach the statistical significance(r=-0,085, p=0,648.). ...
Looking for online definition of atrial systole in the Medical Dictionary? atrial systole explanation free. What is atrial systole? Meaning of atrial systole medical term. What does atrial systole mean?
TY - JOUR. T1 - Left ventricular function after coronary artery bypass. Non-invasive study by systolic time intervals. AU - de Caprio, L.. AU - Rengo, F.. AU - Spampinato, N.. AU - Carlomagno, A.. AU - Chiariello, L.. AU - Spinelli, L.. AU - Romano, M.. PY - 1980. Y1 - 1980. UR - http://www.scopus.com/inward/record.url?scp=0018942327&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0018942327&partnerID=8YFLogxK. M3 - Article. C2 - 6970482. AN - SCOPUS:0018942327. VL - 35. SP - 93. EP - 105. JO - Acta Cardiologica. JF - Acta Cardiologica. SN - 0001-5385. IS - 2. ER - ...
Assessment of cardiac structure and function is central to the care of patients with heart disease. Cardiac magnetic resonance (CMR) is the gold standard for such assessment, however it is expensive and oftentimes not readily accessible. We sought to evaluate the utility of electrocardiographic (ECG) and impedance-based parameters in estimating the amount of myocardial scar, left ventricular (LV) systolic function and myocardial deformation. Consecutive patients (n = 241; 42% female; mean age 55 years) undergoing clinical CMR and ECG assessments were recruited. ECG analysis was performed manually, using both the Modified Selvester Score (MSS) and the presence of fractionated QRS (fQRS) signals, and impedance testing using the Non-Invasive Cardiac System (NICaS). While MCS was of value, neither fQRS nor NICaS meaningfully predicted scar extent, LV systolic function. Or the amount of myocardial deformation. These results support additional investigation of the utility of the MSS in estimating ...
1. In the anesthetized dog, end-diastolic, end-systolic and stroke volumes for the left ventricle have been calculated according to the method of Holt from dilution curves recorded at the aortic root. For heart rates of less than 120 beats per minute, the catheterdensitometer systems used gave 90 to 95 per cent of the true concentration in the aortic root at the end of diastole.. 2. Average volumes of 2.96, 1.63 and 1.33 ml./Kg. of body weight were calculated for each of these parameters. The interindividual and intraindividual variations about these means amounted to ± 30 to 50 per cent.. 3. In approximately 15 per cent of the dilution curves the concentration of dye in the aortic root during early systole (phase of maximal ejection) showed a transient, markedly low value compared with that of the end of diastole. This can be explained only on the basis of the preferential ejection from the heart in early systole of the undyed, newly entering blood from the left atrium, which had mixed poorly ...
in Lancet (2011), 378(9792), 676-83. BACKGROUND: Many patients with heart failure remain symptomatic and have a poor prognosis despite existing treatments. Decreases in myocardial contractility and shortening of ventricular systole are ... [more ▼]. BACKGROUND: Many patients with heart failure remain symptomatic and have a poor prognosis despite existing treatments. Decreases in myocardial contractility and shortening of ventricular systole are characteristic of systolic heart failure and might be improved by a new therapeutic class, cardiac myosin activators. We report the first study of the cardiac myosin activator, omecamtiv mecarbil, in patients with systolic heart failure. METHODS: We undertook a double-blind, placebo-controlled, crossover, dose-ranging, phase 2 trial investigating the effects of omecamtiv mecarbil (formerly CK-1827452), given intravenously for 2, 24, or 72 h to patients with stable heart failure and left ventricular systolic dysfunction receiving guideline-indicated ...
in Lancet (2011), 378(9792), 676-83. BACKGROUND: Many patients with heart failure remain symptomatic and have a poor prognosis despite existing treatments. Decreases in myocardial contractility and shortening of ventricular systole are ... [more ▼]. BACKGROUND: Many patients with heart failure remain symptomatic and have a poor prognosis despite existing treatments. Decreases in myocardial contractility and shortening of ventricular systole are characteristic of systolic heart failure and might be improved by a new therapeutic class, cardiac myosin activators. We report the first study of the cardiac myosin activator, omecamtiv mecarbil, in patients with systolic heart failure. METHODS: We undertook a double-blind, placebo-controlled, crossover, dose-ranging, phase 2 trial investigating the effects of omecamtiv mecarbil (formerly CK-1827452), given intravenously for 2, 24, or 72 h to patients with stable heart failure and left ventricular systolic dysfunction receiving guideline-indicated ...
The dilemma of isolated systolic hypertension.: Isolated systolic hypertension, characterized by elevated systolic blood pressure (greater than 150 to 165 mm Hg
Staessen JA, Fagard R, Thijs L, Celis H, Arabidze GG, Birkenhäger WH, Bulpitt CJ, de Leeuw PW, Dollery CT, Fletcher AE, Forette F, Leonetti G, Nachev C, OBrien ET, Rosenfeld J, Rodicio JL, Tuomilehto J, Zanchetti A. Randomised double-blind comparison of placebo and active treatment for older patients with isolated systolic hypertension. The Systolic Hypertension in Europe (Syst-Eur) Trial Investigators. Lancet. 1997; 350(9080): 757-64 ...
STI were measured on the 7th day after acute myocardial infarction in 144 male patients. These patients were reviewed at 6 weeks and 86 were reinvestigated and reviewed at 6 months. The STI could not predict the patients who would have either angina
now, today well be talking about the cardiac cycle. and the cardiac cycle well be discussing in two fashions, and one way we will discussing cardiac cycle while I will be doing different diagrams and in second phase, Well discuss the cardiac cycle Uhhhhh, When I will be presenting the errands during the cardiac cycle Graphically So first of all, ...
Among this large group of young and middle-aged treated hypertensive subjects, IDH proved to be a favorable finding. By contrast, a wide pretreatment PP was strongly associated with the occurrence of MI despite successful treatment. Among subjects who had MI before age 60, pretreatment diastolic pressure was similar to that of subjects who did not experience events.. Moreover, when subjects with IDH were further stratified by systolic pressure above or below 140 but still less than 160 mm Hg, it was found that MIs occurred exclusively among those with borderline systolic hypertension. No subject with a systolic BP below 140 mm Hg experienced an MI regardless of the level of diastolic pressure (90 to 115 mm Hg).. Subjects with SDH were older and had higher cholesterol and blood glucose levels and were more likely to be female, smoke cigarettes, and have LVH on ECG than IDH subjects. All BP measures in the SDH group were higher than in the IDH group. Clearly, these factors help to explain the ...
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Figure 3.1 illustrates the geometric relationships between the LFT (Marker#29), APT (Marker#31), SH (Marker#22), RFT (Marker#24), and PPT (Marker#33) for diastole (left panel) and systole (right panel).. ...
Tricuspid Annular Plane Systolic Excursion [TAPSE] in a patient with severe PAH during a vasodilatory test with epoprostenol: Left panel depicts the localizatio
TY - JOUR. T1 - Left ventricular global systolic function assessment by echocardiography. AU - Chengode, Suresh. PY - 2016/10/1. Y1 - 2016/10/1. N2 - The left ventricle, with its thickened myocardial walls, unlike the right ventricle has no measurable geometric shape. It has a conical apex and its function quantification, needs intensive, 2D, 3D and M mode transesophageal echocardiography, which is described in this review.. AB - The left ventricle, with its thickened myocardial walls, unlike the right ventricle has no measurable geometric shape. It has a conical apex and its function quantification, needs intensive, 2D, 3D and M mode transesophageal echocardiography, which is described in this review.. KW - Echocardiography. KW - Intraoperative or intensive care setting. KW - Left ventricular global systolic function. UR - http://www.scopus.com/inward/record.url?scp=84993953630&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=84993953630&partnerID=8YFLogxK. U2 - ...
Background Right ventricular ejection fraction (RVEF) is an emerging prognostic predictor of patients with pulmonary hypertension (PH).. Aim We sought to evaluate the accuracy and suitability of two echocardiographic parameters of right ventricular systolic function: tricuspid annular plane systolic excursion (TAPSE) and systolic lateral tricuspid annular motion velocity (TVlat) in the monitoring of RVEF of PH patients.. Methods Consecutive 37 patients with PH (median pulmonary arterial pressure 36 (28 -43) mmHg) were studied. We measured TAPSE and TVlat as echocardiographic indices of RVEF. TAPSE and TVlat measured at baseline and at follow-up, and the changes during follow-up were compared with those of magnetic resonance imaging (MRI)-derived RVEF. Receiver operating characteristic (ROC) analysis was conducted to calculate the cut-off levels of TAPSE and TVlat for the identification of patients with improved RVEF.. Results TAPSE and TVlat were significantly correlated with MRI-derived RVEF at ...
Life expectancy < 3 months Renal insufficiency Pregnant Unable to follow-up All enrolled patients had a TTE performed by cardiologists looking for signs of RV dysfunction, including TAPSE on A4C. Study outcomes: All-cause mortality at 30 days, secondary outcome was PE-specific mortality Results:. 782 patients were included (66 others were removed due to incomplete TTE documentation, those excluded did not differ in terms of demographics, past history, clinical presentation). All were anticoagulated.. TAPSE range was 0.9-4.0 cm, with a median of 2.0 cm. ROC Curve analysis showed that the best cut-off for PE was 1.6 cm. 146 of the 782 patients had a TAPSE of < 1.6 cm. These patients were older, less likely to be male, had a higher prevalence of chronic heart disease or AFib, and more signs of clinical severity (syncope, tachycardia, low sats, hypotension [Editor note: presumably only brief episodes of hypotension since a normal blood pressure was required for inclusion]). 35 patients died by 30 ...
This study shows a substantial benefit with atorvastatin therapy in patients with systolic HF due to a nonischemic etiology. The LV systolic function improved significantly in the cohort of patients treated with atorvastatin, compared with a decline in systolic function in patients treated with placebo over the 12-month study period. In addition, there were reductions in both LV end-diastolic and end-systolic dimensions in the atorvastatin group when compared with placebo. These findings suggest that atorvastatin might retard the progression of adverse myocardial remodeling in patients with nonischemic HF. Finally, atorvastatin therapy was associated with reductions in levels of hsCRP, TNF-α RII, and IL-6 as well as an increase in E-SOD activity, suggesting an association between changes in pro-inflammatory and pro-oxidative markers and LV systolic function.. The patients in our study were largely either NYHA functional class II or III in symptoms. Baseline medical therapy was good, with 88% of ...
BACKGROUND: Myocardial dysfunction in children diagnosed with mitochondrial disease is an ominous sign and has been associated with substantial increased mortality rates. Early detection of cardiac involvement would therefore be desirable. Two dimensional strain echocardiography (2DSTE) has proven to be more sensitive than conventional echocardiography for the detection of early myocardial dysfunction in various (cardiac) conditions. AIMS: To determine left ventricular systolic function in children with mitochondrial disorders by means of physical examination, electrocardiography (ECG), conventional echocardiography and 2DSTE. METHODS: A total of 27 children with established mitochondrial disease and 54 age-matched control subjects underwent cardiac evaluation. Longitudinal, circumferential and radial peak systolic strain (S) values were determined as well as peak systolic strain rate (Sr) and the time to peak global systolic strain (T2P). One Way analysis of Variance was performed to assess the ...
CHAPTER II: CARDIAC MECHANICS Asst. Prof. Dr. Emre Hamurtekin EMU Faculty of Pharmacy 1. 2. 3. 4. CARDIAC CYCLE CARDIAC OUTPUT DETERMINANTS of CARDIAC OUTPUT CARDIAC WORK encyclopedia.lubopitko-bg.com medical-dictionary.thefreedictionary.com • Cardiac cycle can be divided into seven phases: 1. Atrial systole 2. Isovolumic ventricular contraction 3. Rapid ventricular ejection 4. Reduced ventricular ejection 5. Isovolumic ventricular relaxation 6. Rapid ventricular filling 7. Reduced ventricular filling • Atrial systole is initiated by …………………... atrial excitation • Atrial systole follows the crest of P wave on the ECG. • Atrial contraction forces a small additional blood into the venticular chamber (atrial kick). • Ventricular systole begins with isovolumic ventricular contraction. • In isovolumic ventricular contraction, when intraventricular pressure rises, mitral valve closes. • In isovolumic ventricular contraction, aortic valve is still held closed by higher ...
Magnetic resonance tagging was used to calculate myocardial strains (15). All studies were obtained on a 1.0-tesla MR unit (Siemens, Erlangen, Germany). Tags are noninvasive markers placed on the myocardium by presaturating planes at end-diastole perpendicular to the subsequent imaging planes. They show up on the images as dark lines that move and deform with the myocardium on which they are inscribed. Five parallel short-axis planes and four radially oriented long-axis planes crossing the center of the LV were defined (Fig. 1). The gravitational centerline of the LV cavity was reached by the best fit connecting the center of the cavity at each of the different short-axis levels. Images were acquired at end-diastole and end-systole in all these planes, using the short-axis planes as tagging planes for the long-axis images and vice versa. By combining the short- and long-axis information, the entire LV wall, except for the apex, could be reconstructed into 32 small cuboids for which the ...
This page includes the following topics and synonyms: Systolic Dysfunction, Left Ventricular Dysfunction, Left Ventricular Failure, Systolic Heart Failure, Left Ventricular Systolic Dysfunction, Heart Failure with Reduced Ejection Fraction.
The aim of this study was to assess characteristic impedance (Zc) of the proximal aorta in young and middle-aged individuals with isolated systolic hypertension (ISH). Zc is an index of aortic stiffness relative to aortic size. In the Dallas Heart Study, 2001 untreated participants 18 to 64 years of age (mean age: 42.3 years; 44% black race) were divided into the following groups based on office blood pressure (BP) measurements: (1) optimal BP (systolic BP [SBP] ,120 mm Hg and diastolic BP [DBP] ,80 mm Hg; n=837); (2) prehypertension (SBP 120-139 mm Hg and DBP 80-89 mm Hg; n=821); (3) ISH (SBP ≥140 mm Hg and DBP ,90 mm Hg; n=121); (4) isolated diastolic hypertension (SBP ,140 mm Hg and DBP ≥90 mm Hg; n=44); and (5) systolic-diastolic hypertension (SBP ≥140 mm Hg and DBP ≥90 mm Hg; n=178 ...
Synonyms for systole and diastole at Thesaurus.com with free online thesaurus, antonyms, and definitions. Dictionary and Word of the Day.
To the Editor:. The JNC-7 guidelines suggested that diastolic blood pressure (DBP) should not be aggressively lowered below 55 to 60 mm Hg because of possible increase in cardiovascular events associated with lower values (pages 1222 and 1229 of the report).1 This conclusion was mainly derived from results of the Systolic Hypertension in the Elderly Program (SHEP).2 However, the committee did not provide similar cutoffs for systolic blood pressure (SBP). In that respect, we are concerned about the experts statement that no increase in coronary events (or J-shaped relationship) has been observed with excessive lowering of SBP (page 1222).1 Indeed, analysis of 7 randomized trials, including the SHEP, suggested that there may be increased risk of cardiovascular and all-cause mortality with lower levels of DBP as well as SBP.3 While the JNC-7 defined a clear goal for control of SBP (,140 mm Hg, and ,130 mm Hg in patients with diabetes and chronic kidney disease), the extent to which SBP must be ...