Technological advancements and industrial applications in the field of Synthetic Biology are growing at an astounding pace, and Concordia is a leading institution in developing this expertise in Canada. SynBioApps is Canadas premier Collaborative Research and Training Experience (NSERC-CREATE) program focused on Synthetic Biology and its real-world applications. To cultivate tomorrows leading synthetic biologists, participating students will be immersed in both academic and industrial synthetic biology applications.. Students will learn how to design and construct cells and proteins for the development of new products related to human health, green technologies, and fundamental biological investigations. As well as methods of DNA construction and data gathering using the latest in automated equipment, bioinformatics tools will be applied to understand the use of computational modeling and design in synthetic biology. Students will benefit from Concordia Universitys excellent facilities and ...

Synthetic Biologics Inc. [AMEX: SYN] plunged by $0.0 during the normal trading session on Tuesday and reaching a high of $0.68 during the day while it closed the day at $0.64. The company report on June 30, 2020 that Synthetic Biologics Announces Submission of IND Application to U.S. FDA for SYN-020

Synthetic Biologics Inc. [AMEX: SYN] plunged by -$0.05 during the normal trading session on Thursday and reaching a high of $0.50 during the day while it closed the day at $0.46. The company report on May 6, 2021 that Synthetic Biologics Reports 2021 First Quarter Operational Highlights and Financia

Purchase Chemical and Synthetic Biology Approaches to Understand Cellular Functions - Part A, Volume 621 - 1st Edition. Print Book & E-Book. ISBN 9780128181171, 9780128181188

Cyanobacteria are appropriate for sustainable, solar-powered biotechnological purposes. Synthetic biology connects biology with computational design and an engineering perspective, however requires environment friendly tools and details about the operate of organic elements and techniques. To allow the event of cyanobacterial Synthetic Biology, a number of molecular tools had been developed and characterised:. (i) a broad-host-range BioBrick shuttle vector, pPMQAK1, was constructed and confirmed to copy in Escherichia coli and three totally different cyanobacterial strains. (ii) The fluorescent proteins Cerulean, GFPmut3B and EYFP have been demonstrated to work as reporter proteins in cyanobacteria, in spite of the robust background of photosynthetic pigments. (iii) Several promoters, like P(rnpB) and variants of P(rbcL), and a model of the promoter P(trc) with two operators for enhanced repression, had been developed and characterised in Synechocystis sp. pressure PCC6803. (iv) It was proven ...

Synthetic biology, however, is still a relatively new scientific field plagued with the trial and error inefficiencies that hamper most technologies in their early stages of development. To help address these problems, synthetic biologists aim to create biological circuits that can be used for the safer and more efficient construction of increasingly complex functions in microorganisms. A central component of such circuits is RNA, the multipurpose workhorse molecule of biology.. A widespread natural ability to sense small molecules and regulate genes has made the RNA molecule an important tool for synthetic biology in applications as diverse as environmental sensing and metabolic engineering, says Adam Arkin, a computational biologist with the U.S. Department of Energy (DOE)s Lawrence Berkeley National Laboratory (Berkeley Lab), where he serves as director of the Physical Biosciences Division. Arkin is also a professor at the University of California (UC) Berkeley where he directs the ...

...ROCKVILLE Md. Nov. 12 2012 /- Synthetic Biologics...Beta-lactamase enzymes have the ability to degrade beta-lactam antibio... C. diff Infection ...In 2009 aggregate costs associated with CDI-related stays in the hosp...,Synthetic,Biologics,to,Acquire,Clinical-Stage,C.,difficile,Infectious,Disease,Program,biological,advanced biology technology,biology laboratory technology,biology device technology,latest biology technology

...ANN ARBOR Mich. May 14 2012 /- Synthetic Biologic...Most recently Dr. Reed served as Chief Medical Officer at Clinical Da... We are very pleased to add an executive of Carols caliber to the Syn...,Synthetic,Biologics,Appoints,Carol,Reed,,M.D.,,as,Senior,Vice,President,of,Clinical,&,Regulatory,Affairs,medicine,advanced medical technology,medical laboratory technology,medical device technology,latest medical technology,Health

Editors Note: This article covers a stock with less than a $100 million market cap. Please be aware of the risks associated with these stocks.Synthetic Biologi

Synthetic Biologics, Inc. is a clinical-stage company leveraging the microbiome to develop therapeutics designed to prevent and treat gastrointestinal (GI) diseases in areas of high unmet need. Our lead clinical candidates are: (1) SYN-004 (ribaxamase) which is designed to degrade certain commonly used intravenous (IV) beta-lactam antibiotics within the gastrointestinal (GI) tract to prevent microbiome damage, C. difficile infection (CDI), overgrowth of pathogenic organisms, the emergence of antimicrobial resistance (AMR) and acute graft-versus-host-disease (aGVHD) in allogeneic hematopoietic cell transplant (HCT) recipients, and (2) SYN-010, which is intended to reduce the impact of methane-producing organisms in the gut microbiome to treat an underlying cause of irritable bowel syndrome with constipation (IBS-C). The Company is also advancing SYN-020, an oral formulation of the enzyme intestinal alkaline phosphatase (IAP) to treat both local GI and systemic diseases.. ...

ROCKVILLE, Md., July 18, 2013 /PRNewswire/ -- Synthetic Biologics Initiates Manufacturing Process for C. difficile Infectious Disease Program. -- FUJIFILM...

ROCKVILLE, Md., Aug. 3, 2017 /PRNewswire/ -- Synthetic Biologics Reports Second Quarter 2017 Operational Highlights and Financial Results. -- SYN-004...

Free Online Library: Synthetic Biologics Announces Positive Topline Results from First Phase 2a Clinical Trial of SYN-004, the Companys Candidate for the Prevention of C. difficile Infection.(Financial report) by PR Newswire; Business News, opinion and commentary Antibiotics Health aspects Clinical trials Gastrointestinal system

Synthetic Biologics, Inc., of Rockville, Maryland, recently released topline results from a Phase 2A study of a new therapy, called SYN-004, which the company is developing to help protect the gut from adverse effects from intravenous (IV) beta-lactam antibiotics.

Synthetic biology, which combines engineering approach in biological systems is getting a strong momentum due to the recent technological advances, which allow us to manipulate the genetic information at an unprecedented scale. Currently synthetic biology is exploiting its potentials and advantages but also bottlenecks. We will review some success stories of synthetic biology in different field of applications, such as medicine, energy and materials. Medical applications of synthetic biology are some of the most promising areas of synthetic biology, particularly for the alternative methods of drug production, biosensors and also different therapeutic applications. Recent developments in our understanding of cellular signaling and host-pathogen interactions provide the opportunity for new types of medical intervention, where we can utilize parts of the existing or reengineer signaling responses connected to various pathological conditions. Knowledge of the ways that microbes use to avoid the human immune

We have created the Knowledgebase of Standard Biological Parts (SBPkb) as a publically accessible Semantic Web resource for synthetic biology (sbolstandard.org). The SBPkb allows researchers to query and retrieve standard biological parts for research and use in synthetic biology. Its initial version includes all of the information about parts stored in the Registry of Standard Biological Parts (partsregistry.org). SBPkb transforms this information so that it is computable, using our semantic framework for synthetic biology parts. This framework, known as SBOL-semantic, was built as part of the Synthetic Biology Open Language (SBOL), a project of the Synthetic Biology Data Exchange Group. SBOL-semantic represents commonly used synthetic biology entities, and its purpose is to improve the distribution and exchange of descriptions of biological parts. In this paper, we describe the data, our methods for transformation to SBPkb, and finally, we demonstrate the value of our knowledgebase with a set of

Synthetic biology is producing a paradigm shift in biotechnology based on the introduction of engineering principles in the design of new organisms by genetic modification (Check, 2005; Haseloff and Ajioka, 2009). Whereas synthetic biology has rapidly permeated microbial biotechnology, the engineering of multicelled organisms following synthetic biology principles is now emerging and is mainly driven by the so-called top-down approaches, where newly engineered genetic circuits are embedded into naturally existing organisms used as a chassis. The plant chassis offers an extraordinarily fertile ground for synthetic biology-like engineering. However, technology still faces the huge challenge of performing engineering-driven genetic designs. One of the main technological challenges of plant synthetic biology requires the construction and transfer of multigene structures to the plant genome. This is putting pressure on developing DNA assembly and transformation technologies adapted to plants. One ...

In this Selected Issues in Depth section we look at two issues. First, Dr John Glass, from the J. Craig Venter Institute, talks about key research in synthetic biology, the creation of synthetic organisms, and the contribution this research might make to medicine. He also considers some ethical and policy issues that will be central to future work in synthetic biology - and to the perception of future work in synthetic biology. Heres a link to Dr Glasss page at JCVI: http://www.jcvi.org/cms/about/bios/jglass . Second, Dr Tim Devarenne of Texas A&M University talks about the potential for using transgenic organisms to produce biofuels. (Heres a link to his lab page: http://devarennelab.tamu.edu/ ). Our first speaker, then, is Dr John Glass. Dr Glass begins our discussion of synthetic biology by outlining how DNA is used to understand cellular life. His argument is that if we can understand what factors are important in the construction and maintenance of whats called minimal

Although a robust network of programs has developed to thwart the potential misuse of synthetic biology, experts urge that awareness of proper safety and security procedures is still a necessary first step to preventing the intentional or accidental release of a synthetic threat [2,9,35]. In March 2017, senior members of DoD discussed with Congress programs to counter new threats of WMD posed by synthetic biology [36]. Aside from government-sponsored programs to counter major synthetic biology threats, efforts to understand the work of scientists and researchers who are part of the do-it-yourself community are underway [37]. The concept of responsible innovation, the idea that researchers bear the primary responsibility for the integrity of their work [38], has never been more important research and development. quickens, it is imperative for the U.S. due to the advent of synthetic biology and and its allies to identify new threats by other emerging dual-threat ...

entry level jobs and internships : synthetic biology has the potential revolutionize the production biofuels, chemicals, materials, etc\. high throughput, specificity, and sensitivity analytical approaches are needed complement synthetic biology approaches enable rapid read\-out microbial

Synthetic biology aims to engineer biological systems for desired behaviors. The construction of these systems can be complex, often requiring genetic reprogramming, extensive de novo DNA synthesis, and functional screening. Herein, we present a programmable, multipurpose microfluidic platform and associated software and apply the platform to major steps of the synthetic biology research cycle: design, construction, testing, and analysis. We show the platforms capabilities for multiple automated DNA assembly methods, including a new method for Isothermal Hierarchical DNA Construction, and for Escherichia coli and Saccharomyces cerevisiae transformation. The platform enables the automated control of cellular growth, gene expression induction, and proteogenic and metabolic output analysis. Taken together, we demonstrate the microfluidic platforms potential to provide end-to-end solutions for synthetic biology research, from design to functional analysis.

ABSTRACT: BACKGROUND: Recombinant protein production is a process of great industrial interest, with products that range from pharmaceuticals to bi...

html, ,ul, ,li,,b,International Genetically Engineered Machine (iGEM) Progect 2013: Combating Shiga-toxin: A synthetic biology approach,/b,,/li, [,a href=http://www.biotech.iitm.ac.in/faculty/nitish.htm, Dr. Nitish Mahapatra ,/a,,,a href=https://home.iitm.ac.in/kraman/lab/, Dr. Karthik Raman ,/a,,; Mar 2013 - Sept 2013] ,br, ,p,,b,Abstract: ,/b,Shiga toxin, a worldwide menace, has killed over 1 million people to date and continues to afflict almost 150 million people each year. Currently, there is no treatment for Shiga toxicosis and it leads to complications in the human system like hemolytic uremic syndrome (HUS) and renal failure. Here, we propose a two-fold, novel synthetic biology approach to combat the lethal effect of the toxin. We aim to neutralize the already produced toxin through a nine amino acid Gb3 mimic peptide. We have engineered the Gb3 mimic along with a cellular export signal (ompF) downstream of AHL(quorum sensing molecule) inducible promoter (pLuxR). We also plan to ...

NEW YORK (GenomeWeb) - Synthetic biology startup Pareto Biotechnologies announced today a technology partnership with DNA2.0 to integrate their technologies to hasten the engineering of proteins in Paretos pipeline.

The synthetic biology market is rapidly evolving, with various technological advancements that have resulted in a paradigm shift within the market. This has resulted in advanced production of synthetic genes and chassis to develop synthetic organisms from scratch. In 2013, the oligonucleotides segment accounted for the largest share of the global synthetic biology market, by tool, while enabling technologies accounted for the largest share of the synthetic biology market, by technology. The medical application segment accounted for a major share of the synthetic biology applications market in 2013.. North America accounted for the largest share of the global synthetic biology market, followed by Europe, Asia, and the Rest of the World (RoW). In the coming years, Europe is expected to witness the highest growth rate, with emphasis on Germany, U.K., France, Denmark, Switzerland, and Rest of Europe. These countries are expected to serve as revenue pockets for synthetic biology manufacturers. The ...

Thorough and accessible, this book presents the design principles of biological systems, and highlights the recurring circuit elements that make up biological networks. It provides a simple mathematical framework which can be used to understand and even design biological circuits. The textavoids specialist terms, focusing instead on several well-studied biological systems that concisely demonstrate key principles. An Introduction to Systems Biology: Design Principles of Biological Circuits builds a solid foundation for the intuitive understanding of general principles. It encourages the reader to ask why a system is designed in a particular way and then proceeds to answer with simplified models.

Kevin Holden is the Head of Synthetic Biology at Synthego. Mr. Holden holds a PhD in Microbiology from University of California, Davis. He has over 10 years of experience in the biotechnology arena, with specific study and research in synthetic biology as well as in engineering, notably-metabolic pathways in microbes.. Synthegos primary work is focused in software and synthetic RNA kits designed for CRISPR genome research and editing. Synthego uses AI and machine learning to assist researchers and developers with automation for genome engineering that provides for efficient research with consistent results, at a price point that allows for savings. With a strong background in engineering, Synthegos team applies engineering principles to synthetic biology practices, especially for gene editing.. Holdens company, Synthego, works with hardware and software and utilizes advanced machine learning to assist in research platforms and technology, such as the CRISPR-Cas9 genome editing technology. ...

Applications on Synthetic Biology, Synthetic Biology conservation, Genomics Products, Synthetic Biology products, Metabolomics, Computational Systems Biology Conference, Structural Biology, Chemical Biology, Stem Cell Biology

Synthetic Biology. 6. Synthetic Biology. What is Synthetic Biology?. Discover Magazine: Scientists of the Year. Undergraduates in Synthetic Bio. international Genetically Engineered Machines. http://parts.mit.edu/registry/index.php/Main_Page. 37 Teams in 2006; 57 in 2007. Slideshow 65399 by mike_john

Ensuring benefits of synthetic biology are realized through responsible development. Synthetic biology specific news, events, publications and more.

Today, MITs Synthetic Biology Center (MIT SBC) announced a collaboration with Pfizer Inc. that is designed to translate leading discoveries in synthetic biology to advance drug discovery and development technologies. This three-year research collaboration spans multiple therapeutic areas at Pfizer and involves several core investigators within the MIT SBC. The MIT SBC is an interdisciplinary research and educational initiative of the Department of Biological Engineering, which integrates faculty from other MIT departments.. In its first 30 years, biotechnology has provided the basic methodology for producing life-saving protein medicines in cells. However, the bio-manufacturing process can be time-consuming and costly, and has remained largely unchanged since the earliest product approvals. There is an opportunity to re-evaluate standard operations, identify areas for improvement, and develop methodologies that potentially may make the biopharmaceutical value chain more cost-efficient.. The ...

The commission found many efforts to shape policy, governance, and regulation related to synthetic biology, but few examples of a broad-based ethical framework upon which to base such proposals. We identified five ethical principles relevant to the social implications of synthetic biology and other emerging technologies and used these to guide our evaluation of the current state of synthetic biology and its potential risks and benefits, as well as our policy recommendations.. The guiding principles are: (1) public beneficence, (2) responsible stewardship, (3) intellectual freedom and responsibility, (4) democratic deliberation, and (5) justice and fairness. These principles are intended to serve as provisional guideposts subject to refinement, revision, and comment.. Public beneficence. The ideal of public beneficence is to act to maximize public benefits and minimize public harm. This principle encompasses the duty of a society and its government to promote individual activities and ...

Ensuring benefits of synthetic biology are realized through responsible development. Synthetic biology specific news, events, publications and more.

A solution to this problem comes not from biology but the relatively new field of Synthetic Biology. Synthetic biologists apply engineering principles and extend genetic engineering techniques to construct new genetic systems. The synthetic biology approach provides teachers and students with a means to learn molecular biology, genetic engineering and microbiology methods in an engineering setting. The students learn while designing, or testing designs of, engineered biological systems. In addition, this approach provides science teachers with a means of exploring numerous state and national technology standards that are hard to address in most science classes. Like genetic engineering, synthetic biology makes use of techniques such as gel electrophoresis, polymerase chain reaction(PCR), restriction enzymes, and cloning. For decades now, these techniques have been used to transfer genes that exist in one organism into the genome of another, and most students are familiar with human insulin ...

Susan is Professor of Synthetic Biology at the University of Edinburgh. She is Director of the Edinburgh Mammalian Synthetic Biology Research Centre, Co-director of the Edinburgh Genome Foundry for synthetic DNA synthesis and assembly. She also holds a prestigious EPSRC Leadership Fellowship in Synthetic Biology. Her research focuses on developing tools for synthetic biology approaches for pathway and genome engineering in bacteria, yeast and mammalian cell systems. The applications of her work include rapid strain engineering for production of high value secondary metabolites, cell lines for protein production, engineering bacteria to generate electricity and developing genetic tools for bio-computation: engineering cells to sense, process and memorise information.. Previously Susan was a lecturer in Biotechnology at the Institute of Molecular, Cell and Systems Biology at the University of Glasgow before being promoted to Professor in 2012. Susan studied microbiology and genetics at the ...

Susan is Professor of Synthetic Biology at the University of Edinburgh. She is Director of the Edinburgh Mammalian Synthetic Biology Research Centre, Co-director of the Edinburgh Genome Foundry for synthetic DNA synthesis and assembly. She also holds a prestigious EPSRC Leadership Fellowship in Synthetic Biology. Her research focuses on developing tools for synthetic biology approaches for pathway and genome engineering in bacteria, yeast and mammalian cell systems. The applications of her work include rapid strain engineering for production of high value secondary metabolites, cell lines for protein production, engineering bacteria to generate electricity and developing genetic tools for bio-computation: engineering cells to sense, process and memorise information.. Previously Susan was a lecturer in Biotechnology at the Institute of Molecular, Cell and Systems Biology at the University of Glasgow before being promoted to Professor in 2012. Susan studied microbiology and genetics at the ...

Using synthetic biology approaches to allow predictable metabolic engineering in algae. The full conference schedule can be found here and there are plans for a 2016 conference in Edinburgh with more involvement from PhD students and postdocs. You can see some highlights from #SBUK2015 below! ...

Synthetic biologist Tal Danino manipulates microorganisms in his lab to create eye-catching, colorful patterns. Heres a look at the process he uses to turn Oh, yuck into Oh, wow.. Synthetic biologist Tal Danino washes his hands constantly, one of the occupational hazards of working with bacteria all day at the Synthetic Biological Systems Lab, which he runs at New York Citys Columbia University. Danino, a TED Fellow, spends most of his time trying to harness bacterias unique properties - the same properties that can make them so dangerous for humans - and turn them into powerful cancer fighters. But when hes not programming bacteria to fight cancer, hes programming them to make art, in part to make difficult scientific principles more accessible. Its nice to use the visual arts to help communicate science, he says, and thats because art really transcends the boundaries of language and also of knowledge. Daninos recent creative endeavors include a feminist installation of ...

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A synthetic biology approach that adds immunostimulatory gene circuits to cancer cells may contribute to combination immunotherapies against cancer

The existing framework primarily describes the scenario in which a specific gene or genes from one organism of known function is added to another reasonably-well characterized organism. The appropriate biosafety level is then determined by an intuitive analysis of the known properties of the source and destination organisms. When considering synthetic systems that involve many genes from many organisms, the task becomes more difficult. It is rarely the case the all the individual components used in a system were identified by the synthetic biologist, and it is also unlikely that the synthetic biologist is familiar with the full biology of the source organisms. Moreover, the assessment of risk is not as simple as when there are only two components. The question is then, how do we assess the risk of compositions of standard biological parts, and how can we document and communicate these risks to other researchers? To a first approximation, the current NIH guidlines rate synthetic biological ...

August 3, 2006. Five MIT researchers are among the pioneers behind a new research center in synthetic biology, a precocious field whose primary long-term goal is to make it easier to design and build useful organisms.. Current work includes refining pieces of DNA into standard biological parts that researchers could then mix and match to produce novel biological systems - such as bacteria that synthesize rare cancer drugs - and also fostering the responsible development and application of next-generation biological technologies.. The Synthetic Biology Engineering Research Center (SynBERC) is funded by a five-year, $17 million grant from the National Science Foundation.. In addition to MIT, participating universities are the University of California at Berkeley; Harvard University; University of California at San Francisco; and Prairie View A&M University. Matching funds from industry and these universities bring the total five-year commitment to $20 million, with NSF offering the possibility of ...

ETH doctoral candidate Nicolas Lapique from the group led by Yaakov Benenson, Professor of Synthetic Biology in the Department of Biosystems Science and Engineering at ETH Zurich in Basel, has now developed a biological circuit that controls the activity of individual sensor components using internal timer. This circuit prevents a sensor from being active when not required by the system; when required, it can be activated via a control signal. The researchers recently published their work in the scientific journal Nature Chemical Biology.. To understand the underlying technology, it is important to know that these biological sensors consist of synthetic genes that are read by enzymes and converted into RNA and proteins. In the controllable biosensor developed by Lapique, the gene responsible for the output signal is not active in its basic state, as it is installed in the wrong orientation in the circuit DNA. The gene is activated via a special enzyme, a recombinase, which extracts the gene ...

Development of advanced synthetic biology tools is always in demand since they act as a platform technology to enable rapid prototyping of biological constructs in a high-throughput manner. EcoFlex is a modular cloning (MoClo) kit for Escherichia coli and is based on the Golden Gate principles, whereby Type IIS restriction enzymes (BsaI, BsmBI, BpiI) are used to construct modular genetic elements (biological parts) in a bottom-up approach. Here, we describe a collection of plasmids that stores various biological parts including promoters, RBSs, terminators, ORFs, and destination vectors, each encoding compatible overhangs allowing hierarchical assembly into single transcription units or a full-length polycistronic operon or biosynthetic pathway. A secondary module cloning site is also available for pathway optimization, in order to limit library size if necessary. Here, we show the utility of EcoFlex using the violacein biosynthesis pathway as an example. ...

Chloroplasts are a major advantage to doing synthetic biology in plants. They produce starch and some amino acids as well as hosting photosynthesis, all fully separated from other cellular functions going on in the rest of the cell. Synthetic biology approaches could turn them into individualised micro-factories inside plant cells, synthesising whatever compound you fancy without poisoning the cell and with almost no risk of any transgenes escaping into other plants.. Stable plastid transformation was first achieved in tobacco in 1990. Since then, chloroplast transformation has been successful in many plant species - a 2009 review by Huan-Hyan Wang et al. (JGG 36:387) contains a nice table summarizing the methods used in each species. Plastid-based biosynthesis of biopharmaceuticals has been researched for years, but synthetic biology technologies make it possible to consider moving beyond synthesis of antigens and relatively simple molecules (for examples see Daniell et al. 2009, Trends in ...

Piscataway, NJ, March 24, 2017 - ​​​​​GenScript USA, Inc., the number one global provider of gene synthesis services, is announcing a partnership with iGEM to engage and expand the synthetic biology research community in China. This will be the ninth year GenScript has supported the iGEM competition, which enables young scientists all over the world to solve real-world scientific and medical challenges.. As a Platinum Partner sponsor of iGEM, GenScript will provide transportation logistics to ensure that all teams in China can receive the iGEM DNA distribution kit and submit their part samples back to iGEM in a timely manner​. GenScript also will work with iGEM to expand and empower the synthetic biology community in China by recruiting more iGEM teams and organizing education workshops. These workshops allow iGEM participants to network and share ideas. With hundreds of Ph.D.-level scientists, GenScript can offer scientific and research-related support to these local ...

Detection of chemical signals is critical for cells in nature as well as in synthetic biology, where they serve as inputs for designer circuits. Important progress has been made in the design of signal processing circuits triggering complex biological behaviors, but the range of small molecules recognized by sensors as inputs is limited. The ability to detect new molecules will increase the number of synthetic biology applications, but direct engineering of tailor-made sensors takes time.. Here we describe a way to immediately expand the range of biologically detectable molecules by systematically designing metabolic pathways that transform nondetectable molecules into molecules for which sensors already exist. We leveraged computer-aided design to predict such sensing-enabling metabolic pathways, and we built several new whole-cell biosensors for molecules such as cocaine, parathion, hippuric acid, and nitroglycerin.. Libis, V., Delépine, B., Faulon, J.L. Expanding biosensing abilities ...

The Bill and Melinda Gates Foundation has awarded Professor James J. Collins (BME, MSE, SE) a Grand Challenges Explorations grant to encourage his labs pursuit of a novel approach to cholera prevention.. In their proposed project, Collins and two postdoctoral fellows in his lab, Ewen Cameron and Peter Belenky, seek to use synthetic biology techniques to engineer a probiotic yogurt bacterium, Lactobacillus gasseri, to detect and kill the cholera bacterium, Vibrio cholerae, in the human intestine. The probiotic could be supplied as an inexpensive, freeze-dried powder to endemic populations to prevent cholera, an acute, food or water-borne diarrheal infection leading to more than 100,000 deaths each year.. We are delighted to be selected for the Gates Foundation program, said Collins. This funding will enable us to explore using innovative synthetic biology approaches to detect and treat cholera infections, a major health problem facing many poor communities in the world, including those in ...

Well-characterized promoter collections for synthetic biology applications are not always available in industrially relevant hosts. We developed a broadly applicable method for promoter identification in atypical microbial hosts that requires no a priori understanding of cis-regulatory element structure. This novel approach combines bioinformatic filtering with rapid empirical characterization to expand the promoter toolkit and uses machine learning to improve the understanding of the relationship between DNA sequence and function. Here, we apply the method in Geobacillus thermoglucosidasius, a thermophilic organism with high potential as a synthetic biology chassis for industrial applications. Bioinformatic screening of G. kaustophilus, G. stearothermophilus, G. thermodenitrificans, and G. thermoglucosidasius resulted in the identification of 636 100 bp putative promoters, encompassing the genome-wide design space and lacking known transcription factor binding sites. Eighty of these sequences ...

Fermentative production of D-phenylglycine. In fermentative production, substances are produced by microorganisms. The advantages of fermentation are manifold: the starting materials are mostly renewable substances such as glucose and the end products have a high enantiomeric (optical) purity. For their experiments, Professor Mast and her team used Streptomyces pristinaespiralis, a bacterium belonging to the group of actinomycetes.. This bacterium naturally produces the amino acid L-Phg as part of the antibiotic pristinamycin. Using a synthetic biology approach, the research group succeeded in modifying the natural L-Phg biosynthetic pathway from S. pristinaespiralis in such a way that the desired D-Phg is produced. The artificial biosynthetic pathway can now also be used for production in other host strains.. Although the production rates are still low, summarizes Yvonne Mast we have not yet fully exploited the possibilities of genetic engineering and are currently exploring ways to increase ...

Considering that 70% of our planets surface is covered by oceans, it is likely that undiscovered biodiversity is still enormous. A large portion of marine biodiversity consists of microbiomes. They are very attractive targets of bioprospecting because they are able to produce a vast repertoire of secondary metabolites in order to adapt in diverse environments. In many cases secondary metabolites of pharmaceutical and biotechnological interest such as nonribosomal peptides (NRPs) and polyketides (PKs) are synthesized by multimodular enzymes named nonribosomal peptide synthetases (NRPSes) and type-I polyketide synthases (PKSes-I), respectively. Novel findings regarding the mechanisms underlying NRPS and PKS evolution demonstrate how microorganisms could leverage their metabolic potential. Moreover, these findings could facilitate synthetic biology approaches leading to novel bioactive compounds. Ongoing advances in bioinformatics and next-generation sequencing (NGS) technologies are driving the ...

In many of the worlds oceans, currents carry debris and pollution originating from coastlines. This waste accumulates in regional gyres - where ocean currents meet, and can reach extremely high concentrations. Plastic is estimated to account for 60-80% of this debris, and is known to be gradually broken down by solar energy and the mechanical action of the sea. This means the majority of the plastic waste are several millimetres in diameter or less, which has made efforts to clean them from the ocean largely unsuccessful. These tiny plastic fragments - microplastics - enter the digestive systems of resident organisms, which are affected either by the physical size of the plastic or its toxicity from adsorbing organic pollutants. UCL iGEM proposes a synthetic biology approach for the bioremediation of micro-plastic pollutants within the marine environment, with emphasis on regions of excessive debris accumulation, such as the Great pacific garbage patch in the North Pacific gyre. We intend to ...

In many of the worlds oceans, currents carry debris and pollution originating from coastlines. This waste accumulates in regional gyres - where ocean currents meet, and can reach extremely high concentrations. Plastic is estimated to account for 60-80% of this debris, and is known to be gradually broken down by solar energy and the mechanical action of the sea. This means the majority of the plastic waste are several millimetres in diameter or less, which has made efforts to clean them from the ocean largely unsuccessful. These tiny plastic fragments - microplastics - enter the digestive systems of resident organisms, which are affected either by the physical size of the plastic or its toxicity from adsorbing organic pollutants. UCL iGEM proposes a synthetic biology approach for the bioremediation of micro-plastic pollutants within the marine environment, with emphasis on regions of excessive debris accumulation, such as the Great pacific garbage patch in the North Pacific gyre. We intend to ...

Over the past few decades, biological research has vastly improved our understanding of life processes at the molecular, organismal and community levels. In recent years, researchers have been able to use this knowledge base and the toolkits of synthetic biology and cellular engineering to address fundamental biological questions. Synthetic biologists and cellular engineers have also been able to repurpose organisms and organismal processes to address important problems in health, manufacturing, energy, ecology and agriculture, profoundly impacting the bioeconomy. With recent technological advances such as the ability to assemble cell-like systems with particular functionalities and the ability to make precision small-scale and large-scale modifications to eukaryotic and prokaryotic genomes using rewriting tools, synthetic biology is poised to enter the age of designer organelles, cell-like systems and organisms. Indeed, progress in rational cell design technology will enable synthetic biology ...

A structural chassis includes a structural chassis and a foam chassis or sock liner sandwiched together to form an assembly that can be inserted into and substantially occupy a footbed of a shoe upper. Discrete sole elements are attached to a bottom side of the upper so as to expose certain portions of the bottom side therebetween. This absence of outsole material in those areas makes the upper collapsible about those areas since the outsole provides no support in those areas. Instead, the structure is provided by the chassis of the chassis, which is customized to the users foot by placing one or more notches in strategic locations along the chassis where the foot naturally flexes. One such notch is located on the chassis in a position that allows the chassis to flex about a forward push-off axis of the foot that runs through the first and second MTP joints. Two collinear notches are formed on the chassis to allow the structural chassis shoe to flex about a lateral push-off axis that runs through the

Sustainability via Synthetic Biology: A Growing Role for Biotechnology in the Chemical Industry. Wednesday, September 20, 2017, 4-5 pm, Elgin Room (E-Quad A224). Brian Pfleger, University of Wisconsin-Madison, (CBE Departmental Seminar) ...

TY - JOUR. T1 - A Synthetic Gene Circuit for Self-Regulating Delivery of Biologic Drugs in Engineered Tissues. AU - Pferdehirt, Lara. AU - Ross, Alison K.. AU - Brunger, Jonathan M.. AU - Guilak, Farshid. PY - 2019/5/1. Y1 - 2019/5/1. N2 - Transient, resolving inflammation plays a critical role in tissue repair and regeneration. In the context of joint disease, however, chronic inflammation following injury or with osteoarthritis can lead to irreversible articular cartilage degradation and joint pain. Developing tissue engineering strategies for the regeneration of articular cartilage remains challenging due to the harsh inflammatory environment of an injured or arthritic joint, which can promote degradation of engineered tissues as well as native articular cartilage. Here, we developed an artificial gene circuit for controlled, cell-based delivery of biologic drugs, based on a nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB)-responsive synthetic promoter. Using ...

By Yong-Bee Lim Synthetic Biology and National Security Policy: Balancing Risk and Innovation to Address the Dual-use Dilemma Mankinds knowledge of technology, and the building blocks of life, has rushed forward in leaps and bounds over the past 50 years. Using various techniques and databases stored with genome data, analyses are now available to health…

The National Research Foundation Singapore (NRF) has announced a new Synthetic Biology Research and Development (R&D) Programme, which will be led by NUS

Some religious believers may see synthetic biology as usurping Gods creative role. The Catholic Church has yet to issue a formal teaching on the field (though it has issued some informal ...

Genetically-encoded biosensors offer a wide range of opportunities to develop advanced synthetic biology applications. Circuits with the ability of detecting and quantifying intracellular amounts of a compound of interest are central to whole-cell biosensors design for medical and environmental applications, and they also constitute essential parts for the selection and regulation of high-producer strains in metabolic engineering. However, the number of compounds that can be detected through natural mechanisms, like inducible transcription factors, is limited; expanding the set of detectable compounds is therefore highly desirable.. Here, we present the SensiPath webserver, accessible at http://sensipath.micalis.fr.. SensiPath implements a strategy to enlarge the set of detectable compounds by screening for multi-step enzymatic transformations converting non-detectable compounds into detectable ones. The SensiPath approach is based on the encoding of reactions through signature descriptors to ...

The present invention is a computing appliance chassis assembly which may support an integration of a plurality of removable modules, including fan modules, power supplies, and a controller module. The computing appliance chassis assembly may also include detachable handles which may allow transport of the computing appliance chassis assembly. A controller chassis may be installed within the computing appliance chassis assembly. A controller chassis assembly may house a controller module and may include rotatable side panels which allow easier access to the components of the controller module. A fan chassis assembly may also be installed within the computing appliance chassis and may house a fan module.

Historical Introduction - Foundations of Synthetic Biology- Biochemistry & Molecular Biology, Gene expression and gene regulation, Signaling, Metabolism, Nonlinear dynamics, Stochastic gene expression - Technology for Synthetic Biology: Biochemical tools Cloning, Recombineering, Genome engineering & editing, Sequencing, Rational design vs. Evolution, Microfluidic techniques - In vitro and cell-free synthetic biology: Bionanoscience, Cell-free biotechnology, Artificial cells, Artificial life - Minimal cells: Reduced genomes, orthogonal chemistries, expanding the genetic code - Synthetic regulatory circuits: Bacterial computation, Memory, Bacterial communication, pattern formation, etc., RNA synthetic biology Engineering issues, metabolic engineering and applications will follow in part ...

Synthetic biology successfully combines aspects of engineering, chemistry, informatics and biology. Different research fields of synthetic biology have evolved over recent years. These contain, for example, the de-novo design of complete organisms, the utilization of building bricks that can be used to engineer tailor-made synthesis pathways for the production of platform chemicals or orthogonal biosystems that are useful tools for protein biochemistry. These orthogonal pairs can be used to generate modified, synthetic proteins.. In the Functional Genomics group, we use different orthogonal pairs to integrate synthetic amino acids, especially amino acids with photocrosslinker reactivity, site-specifically into proteins. With this approach, for example, virulence factors of the human pathogenic yeast Candida albicans are analyzed for their protein-protein interactions.. Furthermore, synthetic biology provides solutions for current challenges in pharmacy, medicine and biology. ...

Synthetic biology technology could lead to new antibiotics, modified protein-generators. Synthetic biology researchers at Northwestern University, working with partners at Harvard Medical School, have for the first time synthesized ribosomes -- cell structures responsible for generating all proteins and enzymes in our bodies -- from scratch in a test tube.. Others have previously tried to synthesize ribosomes from their constituent parts, but the efforts have yielded poorly functional ribosomes under conditions that do not replicate the environment of a living cell. In addition, attempts to combine ribosome synthesis and assembly in a single process have failed for decades.. Michael C. Jewett, a synthetic biologist at Northwestern, George M. Church, a geneticist at Harvard Medical School, and colleagues recently took another approach: they mimicked the natural synthesis of a ribosome, allowing natural enzymes of a cell to help facilitate the man-made construction.. The technology could lead to ...

The broader move in tech stocks may have also helped XELA this year. The company offers business process automation to a customer base of 4,000 businesses across 50 countries. This has added to Exelas progress over the last year. In its last quarterly update, the company reported significant revenue growth, year-over-year. Operating income for the third quarter was $4.8 million. This didnt even compare to the operating loss of $93.9 million in the third quarter of 2019. The year-over-year increase in operating income was attributable to several operational changes. While some uncertainty related to the pandemic still remains, we continue to execute well against our plan for value creation in this current environment. Our sequential margin expansion, improving cash flow, and rising liquidity in the third quarter is further evidence of our progress, said Ronald Cogburn, Chief Executive Officer of Exela, in response to these results. Finally, Synthetic Biologics woke up in a big way this year. ...

Increased dividends Digital Realty Tr .73 from .68 Group 1 Automotive .14 from .13 Noranda Aluminum .04 from .03 Scripps Netwks Intact .12 from .10 Announced spinoff Atlas Energy-0.1021 of a share of Atlas Resource Partners Declared stock splits Alaska Air Group 2-for-1 Stock splits this week Market Vectors Biotech 3-1 Market Vectors Bank & Brokerage 2-1 Market Vectors Oil Services 3-1 Market Vectors Pharmaceuticals 2-1 Market Vectors Retail 3-1 Spirit Air 1.43 vs 2.72 Realty Income Corp 7.375pc pfD Mar. 1 Acquired by private equity Campus Crest Communities 8pc pfA Realty Income Corp 6.625pc pfF Constellation Energy Partners LLC NASDAQ Global and Global Select Markets Stocks removed from trading NASDAQ Global and Global Select Markets Blue Coat Systems Inc Northern States Financial Corp Shanda Interactive Entertainment Synovis Life Technologies Inc Adeona Pharmaceuticals Inc to Synthetic Biologics Inc

This creative convergence sounds exciting but scientific advance and technological innovation do not come without some risks, so it is important to tackle concerns early to maintain high levels of public and investor confidence. Despite a federal investment of $1.5 billion in nanotechnology research and development in 2008, the amount devoted to understanding environmental, health and safety impacts is still a small fraction (below 4 percent). It is unclear how much is being spent on addressing the potential risks of synthetic biology, but the numbers and the strategy need to be openly debated and soon. Navigating the shoals of public opinion around synthetic biology will be much more difficult than nanotechnology. The public and the press, especially in Europe, will view synthetic biology through the lens created by the debate over genetically modified organisms, and some recent research shows that the American public may be highly suspicious of scientists creating novel genetic code (10, 11, 12 ...

Our research focuses on the development and use of synthetic biology tools to scrutinize the biology of the biospheres most abundant protein, the photosynthetic CO2-fixing enzyme Rubisco (ribulose-1,5-bisphosphate carboxylase/oxygenase). The research provides training in molecular biology, protein engineering (directed evolution), enzyme kinetics, biochemistry, plastome transformation, tissue culture, measuring leaf photosynthesis and plant growth.

In Michigan, scientists at Michigan State University developed synthetic biology tools to co-produce high-value compounds in plants. The new tools allow to produce both terpenoids and oil, a biofuel resource, in plant leaves. Modern applications for terpenoids range wide, from pharmaceuticals, fragrances, nutraceuticals and biopesticides, to chemical feedstocks. Terpenoids form the largest class of natural […]. Read More. ...

The research efforts of EMBB group members are focused on understanding biofilm-mediated environmental processes and harnessing the power of microbial biofilms to address environmental issues. Specifically, we use environmental/(bio)chemical engineering, microbiology, and molecular/synthetic biology tools and develop new tools to ...

Marchantia polymorpha is the best characterised liverwort plant. It is a common weed, and can grow quickly and resiliently. The relative simplicity of genetic networks in Marchantia, combined with the growing set of genetic manipulation, culture and microscopy techniques, are set to make this primitive plant a major new system for analysis and engineering.. Major benefits of working with Marchantia are: ...

Recent years have seen a remarkable increase in the nonnatural production of terpenoids by the microbial route. This is due to advancements in synthetic biology tools and techniques, which have overcome the challenges associated with the nonnative production of terpenoids from microbial hosts. ...

We present a methodology for the design, construction and modification of synthetic gene networks. This method emphasizes post-assembly modification of constructs based on network behavior, thus facilitating iterative design strategies and rapid tuni

In a DER SPIEGEL interview, genetic scientist Craig Venter discusses the 10 years he spent sequencing the human genome, why we have learned so little from it a decade on and the potential for mass production of artificial life forms that could be used to produce fuels and other resources.. SPIEGEL: Mr. Venter, when the elite among gene researchers undertook the decoding of the human genome, you were their greatest enemy. They called you Frankenstein, blood sucker, Darth Venter and even asshole. Why do you attract so much hostility?. Venter: Well, nobody likes to be beaten -- by superior intelligence, planning and technology. That gets people upset.. SPIEGEL: Every area of science is competitive. But it doesnt lead to that kind of hostility in all areas.. Venter: The human genome project was completely different, it was supposed to be the biggest thing in the history of biological sciences. Billions in government funding for a single project -- we had never seen anything like that before ...

Synthetic biology is the design and construction of new biological entities such as enzymes, genetic circuits, and cells, or the redesign of existing biological systems. The field builds upon advances in molecular, cell, and systems biology and seeks to transform biology.. The element that distinguishes synthetic biology from traditional molecular and cellular biology is the focus on the design and construction of core components that can be modeled, understood, and tuned to meet specific performance criteria, and the assembly of these smaller parts and devices into larger integrated systems that solve specific problems. The focus of SynBERC is to make biology easier to engineer, says SynBERC director Jay Keasling, professor of chemical engineering and bioengineering. SynBERC will construct the biological components that will allow engineers to build biological solutions to important societal problems, such as the environmentally friendly production of chemicals using microbes, or replacing ...

A colored scanning electronic micrograph of synthesized Mycoplasma mycoides, bacteria with a genome containing one million base pairs. Now scientists have created an E.coli genome four times larger.. After some preliminary experiments, he and his colleagues designed a modified version of the E. coli genome on a computer that only required 61 codons to produce all of the amino acids the organism needs.. Instead of requiring six codons to make serine, this genome used just four. It had two stop codons, not three. In effect, the researchers treated E. coli DNA as if it were a gigantic text file, performing a search-and-replace function at over 18,000 spots.. Now the researchers had a blueprint for a new genome four million base pairs long. They could synthesize the DNA in a lab, but introducing it into the bacteria - essentially substituting synthetic genes for those made by evolution - was a daunting challenge.. The genome was too long and too complicated to force into a cell in one attempt. ...

Karl Brune, leading the work in Professor Mark Howarths lab in Oxfords Department of Biochemistry explained: Current techniques to develop VLP-based vaccines take time and do not always work. Whilst getting the pathogen parts to stick to the carrier VLP, often problems such as misassembly or misfolding arise that make the vaccine ineffective at generating protective immunity.. This failure rate translates into high development costs in trying to create vaccines against major diseases such as malaria, HIV and cancer.. A more reliable way of assembling candidate vaccines could make them much cheaper and improve the chances of vaccines against these illnesses. A faster way of assembling vaccines may also help with the rapid development of new vaccines against unforeseen disease outbreaks., says Dr Darren Leneghan, leading the immunisation work with Dr Sumi Biswas and Professor Simon Draper in Oxfords Jenner Institute, which specialises in vaccine development.. Karl Brunes work has now ...

Biology is fast becoming an information science, with large databases and sophisticated algorithms now essential tools in the field. Allen School faculty and students collaborate with researchers in biology and medicine on a wide range of computational problems that will ultimately enable us to understand complex biological systems. The Allen School and the University of Washington are at the forefront of exciting innovations at the intersection of computation and biology to advance scientific discovery, develop new diagnostics and therapeutics, and usher in a new era of personalized medicine. Learn more about our work by visiting the pages of our individual researchers and labs and explore some of our highlighted projects below.. Also check out or work on molecular information systems, a partnership with Microsoft aimed at developing digital data storage and computing capabilities using synthetic DNA.. ...

A research study titled, Synth e tic Biology Market by Product (Oligonucleotide Synthesis, DNA Synthesis, Standardized DNA Parts, Synthetic Genes,

Installation view of Resurrecting the Sublime at Biennale Internationale Design Saint-Étienne, March 2019. Vitrines with smell diffusion, lava and limestone boulders, animations, and ambient soundscape. Left: Hibiscadelphus wilderianus Rock. Right: Orbexilum stipulatum. Photograph: Pierre Grasset.. Could we ever again smell flowers driven to extinction by humans? This is the kind of question that motivates Christina Agapakis, a synthetic biologist and Creative Director at Ginkgo Bioworks, a biotechnology company that designs microbes for industries such as the perfume and the flavour industries. Agapakis is interested in challenging the duality embedded into synthetic biology: artificial vs natural. What will this split look like in the near future when we do more genetic engineering and mess with nature? How will our idea of nature change? She decided to explore the question through an experiment that saw her collaborate with artists to bring back the smell of an extinct plant using the same ...

Professor Paul A Hoskisson is a fellow of the Royal Society of Edinburgh, and Royal Academy of Engineerings research chair in engineering biology of antibiotic production, University of Strathclyde. The RSE is Scotlands National Academy, which brings great minds together to contribute to the social, cultural and economic well-being of Scotland. ...

In 2010, DARPA invested 6 million in a project called BioDesign.Wired and Popular Science have both written on this topic. Essentially, Bio-Design would override evolution and eliminate the randomness of natural evolutionary enhancement. DARPA would create molecules that bolster cell resistance to death and ultimately program cells to live indefinitely. Additionally, cells would be programmed with a kill switch. According to DARPA as stated in Wired (see: http://www.wired.com/dangerroom/2010/20/pentagon-looks-to-breed-immortal-synthetic-organisms-molecular-kill-switch-included), BioDesign could be used to Develop strategies to create a synthetic organism self-destruct option to be implemented upon nefarious removal of organism. The project comes as DARPA also plans to throw 20 Million into a new synthetic biology program, and 7.5 million into increasing several decades the speed with which we sequence, analyze and functionally edit cellular genomes. Could DARPAs synthetic biology ...

In 2010, DARPA invested 6 million in a project called BioDesign.Wired and Popular Science have both written on this topic. Essentially, Bio-Design would override evolution and eliminate the randomness of natural evolutionary enhancement. DARPA would create molecules that bolster cell resistance to death and ultimately program cells to live indefinitely. Additionally, cells would be programmed with a kill switch. According to DARPA as stated in Wired (see: http://www.wired.com/dangerroom/2010/20/pentagon-looks-to-breed-immortal-synthetic-organisms-molecular-kill-switch-included), BioDesign could be used to Develop strategies to create a synthetic organism self-destruct option to be implemented upon nefarious removal of organism. The project comes as DARPA also plans to throw 20 Million into a new synthetic biology program, and 7.5 million into increasing several decades the speed with which we sequence, analyze and functionally edit cellular genomes. Could DARPAs synthetic biology ...