New advances in instrumentation, demonstration of proof-of-principle studies, and development of new tools and methods for data analysis and interpretation have enabled the technique of Synchrotron Radiation Circular Dichroism (SRCD) spectroscopy to become a useful tool for structural and functional biology. This paper discusses the characterisation of two new SRCD beamlines, CD1 at the Institute for Storage Rings (ISA), Denmark and 4B8 at the Beijing Synchrotron Radiation Facility (BSRF), China, and new applications of the method for examining biological systems ...
article{9c427bbf-e48d-404f-aa8d-386a5072b5fd, abstract = {,p,Apolipoprotein A-I (apoA-I) in high-density lipoprotein (HDL) provides cardiovascular protection. Synchrotron radiation circular dichroism (SRCD) spectroscopy was used to analyze the dynamic solution structure of the apoA-I protein in the apo- and HDL-states and the protein structure conversion in HDL formation. Wild-type apoA-I protein was compared to human variants that either are protective (R173C, Milano) or lead to increased risk for ischaemic heart disease (A164S). Comparable secondary structure distributions in the HDL particles, including significant levels of beta strand/turn, were observed. ApoA-I Milano in HDL displayed larger size heterogeneity, increased protein flexibility, and an altered lipid-binding profile, whereas the apoA-I A164S in HDL showed decrease thermal stability, potentially linking the intrinsic HDL propensities of the variants to disease risk.,/p,}, articleno = {13540}, author = {Giudice, Rita Del and ...
X-ray computed tomography (CT) experiments performed at synchrotron radiation facilities require adequate computing and storage resources due to the large amount of acquired and reconstructed data produced. To satisfy the heterogeneous needs of beamline users, flexible solutions are also required. Moreover, the growing demand of quantitative image analysis impose an easy integration between the CT reconstruction process and the subsequent feature extraction step. This paper presents some of the software solutions adopted by the SYRMEP beamline of the Italian synchrotron radiation facility Elettra. By using the enhanced version of the reconstruction software here presented as well as data reduction and data analysis tools, beamline users can easily implement an integrated and comprehensive approach to the digital image processing and image analysis required by a tomography-oriented scientific workflow.. ...
Synchrotron radiation X-ray tomographic microscopy (SRXTM) was used to characterize the three-dimensional microstructure, geometry and distribution of different phases in two shale samples obtained from the North Sea (sample N1) and the Upper Barnett Formation in Texas (sample B1). Shale is a challenging material because of its multiphase composition, small grain size, low but significant amount of porosity, as well as strong shape- and lattice-preferred orientation. The goals of this round-robin project were to (i) characterize microstructures and porosity on the micrometer scale, (ii) compare results measured at three synchrotron facilities, and (iii) identify optimal experimental conditions of high-resolution SRXTM for fine-grained materials. SRXTM data of these shales were acquired under similar conditions at the Advanced Light Source (ALS) of Lawrence Berkeley National Laboratory, USA, the Advanced Photon Source (APS) of Argonne National Laboratory, USA, and the Swiss Light Source (SLS) of ...
Inaugurated in 1994, the ESRF is the worlds most intense x-ray source, a public center of excellence for fundamental research, also committed to applied and industrial research. Located in Grenoble, France, the ESRF is a model of international cooperation with 21 partner nations, of which 13 are Members and 8 are Scientific Associates.. The ESRF - the European Synchrotron Radiation Facility - is the most intense source of synchrotron-generated light, producing x-rays 100 billion times brighter than the x-rays used in hospitals. These x-rays, endowed with exceptional properties, are produced at the ESRF by the high energy electrons that race around the storage ring, a circular tunnel measuring 844 meters in circumference. Each year, the demand to use these x-ray beams increases and thousand of scientists from around the world come to Grenoble, to access the 43 highly specialized experimental stations, called beamlines, each equipped with state-of-the-art instrumentation, operating 24 hours a ...
Companies need to constantly look through the structure of materials to meet the current needs of society and the economy by developing new products and processes or improve existing ones, making them more efficient and cheap.. Research done with the use of synchrotron light sources have benefited the development of numerous products and components, from baby diapers to turbines for aircraft. They have been - and still are - used in the development of more durable, resistant and inexpensive batteries for electric cars, cellphones and laptops and the development of new semiconductors, capable of increasing the efficiency of organic solar cells for the production of electricity.. Among the largest US companies, according to Fortune magazines ranking, at least 32 of them use synchrotron light sources in the development of their products. Exxon Mobil, Chevron, General Electric, Ford Motor, HP, GM, IBM, Boeing, Johnson & Johnson, Pfizer, Novartis, Intel and 3M are among these companies.. Companies ...
News and bulletins about European Synchrotron Radiation Facility for biotechnology, life sciences, pharmacy, healthcare, diagnostics, bioinformatics, updated daily and relevant to the sector, can be found on this page.
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In the framework of the HL-LHC project, the vacuum performance of new surface material needs to be studied. In particular, a-C coating is proposed as an anti-multipactor surface in the HL-LHC Inner Triplets. Since the protons in the HL-LHC Inner Triplets will generate synchrotron radiation (SR) with ~ 10 eV critical energy and ~ 10^16 ph/m/s flux, it is therefore of great importance to study the impact of such photons on a-C coating held at room and cryogenic temperature and compare the results against present LHC material. This paper describes construction and parameters of experimental set-up based on new Synchrotron Radiation beamline from booster synchrotron BEP at BINP. The experimental program releasing in collaboration between CERN and BINP for performing measurements of photon stimulated gas desorption, photon distribution and photo-electron emission provoked by synchrotron radiation are presented ...
Cereal crops accumulate low levels of iron (Fe) of which only a small fraction (5-10%) is bioavailable in human diets. Extensive co-localization of Fe in outer grain tissues with phytic acid, a strong chelator of metal ions, results in the formation of insoluble complexes that cannot be digested by humans. Here we describe the use of synchrotron X-ray fluorescence microscopy (XFM) and high resolution secondary ion mass spectrometry (NanoSIMS) to map the distribution of Fe, zinc (Zn), phosphorus (P) and other elements in the aleurone and subaleurone layers of mature grain from wild-type and an Fe-enriched line of rice (Oryza sativa L.). The results obtained from both XFM and NanoSIMS indicated that most Fe was co-localized with P (indicative of phytic acid) in the aleurone layer but that a small amount of Fe, often present as hotspots, extended further into the subaleurone and outer endosperm in a pattern that was not co-localized with P. We hypothesize that Fe in subaleurone and outer ...
During FY 1997 Brookhaven National Laboratory celebrated its 50th Anniversary and 50 years of outstanding achievement under the management of Associated Universities, Inc. This progress report is divided into the following sections: (1) introduction; (2) science highlights; (3) meetings and workshops; (4) operations; (5) projects; (6) organization; and (7) abstracts and publications.
Powder diffraction was developed independently in 1916 by Peter Debye and Paul Scherrer in Germany and Albert Hull in the U.S. To commemorate this 100th anniversary, a half-day symposium on historical developments in powder diffraction as well as contemporary APS work was held on November 11, 2016.. Where the speakers have agreed, recordings of the talks and slides have been placed in youtube.. David Cox, Brookhaven National Laboratory (Retired) Some Recollections from the Early Days of Neutron and Synchrotron X-ray Powder Diffraction. Tim Fawcett, International Centre for Diffraction Data 100 Years of Powder Diffraction. Pete Chupas, Advanced Photon Source 80+ Years of Pair Distribution Function Measurements. Andrey Yakovenko, Advanced Photon Source New In-Situ Capabilities at 17-BM Rapid Acquisition Powder Diffraction Line. Saul Lapidus, Advanced Photon Source Improving On Great: The High-Resolution Powder Diffractometer, 11-BM. Olaf J. Borkiewicz, Advanced Photon Source Whats New ...
This paper describes the effects of intense synchrotron radiation beams from the Advanced Photon Source on small ferritin crystals suspended in solution. Typical powder diffraction, shown in the figure, identifies a number of individual crystals within the X-ray beam. After exposures in the range 2×107 Grays, the crystals were found to disintegrate suddenly in a spectacular way, as captured on the JSR cover image. The peak evolution to larger momentum transfer implies that the crystals collapse, possibly due to loss of hydration.. ...
Its a Friday night. Most of the population at Argonne, those with day jobs, have long since left-but the lights are still on at the Advanced Photon Source, and they will be all weekend, and the week after that, and the week after that. Read All-nighters for Science, Louise Lerners (ANL-CPA) account of an overnight shift during a recent user-beam run at the U.S. Department of Energy Office of Sciences Advanced Photon Source national research facility at Argonne National Laboratory.. The article appears in the spring 2017 issue of Argonne Now, the Laboratorys science magazine.. Click here to access the article All-nighters for Science.. Click here to access the entire spring issue of Argonne Now.. Also featured in the spring 2017 issue is A DRUG TO FIGHT HIV, one of the Four examples of industry gaining an edge by using Argonne facilities.. O O O O O O O O O O. The Advanced Photon Source is a U.S. Department of Energy (DOE) Office of Science User Facility operated for the DOE Office of ...
This review updates the recent advances and applications of three prominent synchrotron radiation techniques, microprobe X-ray fluorescence spectroscopy/imaging, X-ray absorption spectroscopy, and infrared microspectroscopy, and highlights how these tools are useful to the medicinal chemist. A brief description of the principles of the techniques is given with emphasis on the advantages of using synchrotron radiation-based instrumentation rather than instruments using typical laboratory radiation sources. This review focuses on several recent applications of these techniques to solve inorganic medicinal chemistry problems, focusing on studies of cellular uptake, distribution, and biotransformation of established and potential therapeutic agents. The importance of using these synchrotron-based techniques to assist the development of, or validate the chemistry behind, drug design is discussed.
2018 The Author(s). Licensee MDPI, Basel, Switzerland. This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0). Received: 11 February 2018 / Revised: 4 March 2018 / Accepted: 6 March 2018 / Published: 8 March 2018. (This article belongs to the Special Issue Processing-Structure-Properties Relationships in Polymers) This research used resources of the Advanced Photon Source (APS), a US Department of Energy (DOE) Office of Science User Facility operated for the DOE Office of Science by Argonne National Laboratory under Contract DE-AC02-06CH11357. The authors acknowledge all the staff at beamline 5-ID-D DND-CAT of the Advanced Photon Source (APS) at the Argonne National Laboratories, especially Steven Weigand and James Rix for their support before and during the synchrotron experiments. The authors acknowledge Mary Beth Kossuth at ...
X-ray synchrotron radiation pseudo-holotomography as a new imaging technique to investigate angiogenesis and bone regeneration in in vivo implanted engineered ...
The Stanford Synchrotron Radiation Lightsource (SSRL) provides synchrotron radiation, a name given to X-rays or light produced by electrons circulating in a storage ring at nearly the speed of light. These extremely bright X-rays can be used to investigate various forms of matter ranging from objects of atomic and molecular size to man-made materials with unusual properties.
Flow- or stretch-induced crystallization (FIC or SIC) is believed to be mainly responsible for the excellent mechanical properties of polymers during real service conditions. With the development of synchrotron radiation X-ray scattering, time resolution has been increased from minutes to millisecond, the in-situ tracing of the structural evolution of polymers under complex external fields becomes possible. Recently, the FIC behaviors of polymers (i.e. natural rubber and polyethylene) during multi-axial deformation like biaxial stretching, film blowing and balloon blowing have been systematically studied by our group with a series of custom-built experimental devices combined with synchrotron radiation X-ray scattering techniques. Considering the phenomenon of frustrating SIC for natural rubber during biaxial stretching, here we proposed a new model for SIC based on the results of theoretical calculation, which decouples the free energy contributions of chain orientation from that of ...
The Department of Energy has approved the technical scope, cost estimate and plan of work for an upgrade of the Advanced Photon Source (APS), a major storage-ring X-ray source at Argonne National Laboratory.
Transforming Clean Energy Technology: A breakthrough by researchers using the U.S. Department of Energys Advanced Photon Source and Advanced Light Source could eliminate a critical obstacle from the storage and distribution of solar energy, a discovery that represents a giant stride toward a clean-energy future.
Last week, Frank Brenker and his colleagues Bart Vekemans, Laszlo Vincze, and Manfred Burghammer analyzed the first track to be extracted from the Stardust Interstellar Collector. We suspected that this is a particle that was ejected from an impact of a high-velocity particle (either an interplanetary dust particle or an interstellar dust particle) on the port (left-side) aft solar panel. We thought that this would be the case for two reasons. We mainly based this expectation on the trajectory - it appears to be pointing back to the aft solar panel - but also on the track shape - it does not show the shock-induced flaring that one usually sees with hypervelocity impacts. Dr. Brenker and colleagues used a highly focussed x-ray beam at the European Synchrotron Radiation Facility (ESRF) in Grenoble, France. ESRF is essentially an x-ray microscope the size of a shopping mall. The incredibly tight focus of this beam (about a tenth of a micron!) is ideal for the analysis of these very tiny samples. ...
The application of the X-ray phase-contrast `edge illumination principle to the highly coherent beams available at synchrotron radiation facilities is presented here. We show that, in this configuration, the technique allows achieving unprecedented angular sensitivity, of the order of few nanoradians. The results are obtained at beamlines of two different synchrotron radiation facilities, using various experimental conditions. In particular, different detectors and X-ray energies (12 keV and 85 keV) were employed, proving the flexibility of the method and the broad range of conditions over which it can be applied. Furthermore, the quantitative separation of absorption and refraction information, and the application of the edge illumination principle in combination with computed tomography, are also demonstrated. Thanks to its extremely high phase sensitivity and its flexible applicability, this technique will both improve the image quality achievable with X-ray phase-contrast imaging and allow ...
Here we report that the equation of state (EOS) of Mo is obtained by an integrated technique of laser-heated DAC and synchrotron X-ray diffraction. The cold compression and thermal expansion of Mo have been measured up to 80 GPa at 300 K, and 92 GPa at 3470 K, respectively. The P-V-T data have been treated with both thermodynamic and Mie-Gruneisen-Debye methods for the thermal EOS inversion. The results are self-consistent and in agreement with the static multi-anvil compression data of Litasov et al. (J. Appl. Phys. 113, 093507 (2013)) and the theoretical data of Zeng et al. (J. Phys. Chem. B 114, 298 (2010)). Furthermore, these high pressure and high temperature (HPHT) data with high precision firstly complement and close the gap between the resistive heating and the shock compression experiment. ...
Additionally your childs portrait will be placed on each of the 34 backgrounds featured on your fall flyer. Only Priority Students (children of key workers, those with EHCP and / or Social Workers) will be invited to attend school from Tuesday 5 January 2021. … This enables parents to pre-select backgrounds, pre-pay for their packages and print out a paid voucher to be included in the picture day envelope. A 4×6 desk calendar, personalized with your childs portrait and a new illustrated quote for each month is sure to be the new center piece of your office. Cart. 144 Bnl jobs available on Indeed.com. The National Synchrotron Light Source II (NSLS-II) at Brookhaven National Laboratory is one of the newest, most advanced third generation synchrotron radiation facilities in the world. BNL offers secure online prepayment for middle and elementary students. 50% off (4 days ago) [50% OFF] bnl school pictures discount code - December 2020. For the families that chose to not place their order ...
Andrzej Joachimiak. Andrzej Joachimiak is an expert in synchrotron-based X-ray crystallography and structural biology. At Argonne, he has made significant contributions to the high-throughput crystallography using synchrotron radiation and the development of state-of-the-art facilities for macromolecular crystallography. The development and integration of the novel synchrotron beamlines, exploitation of the anomalous signal-based phasing methods in the third-generation environment and integration of hardware and software at the Structural Biology Center beamlines at the Advanced Photon Source contributed very strongly to the enhanced efficiency of such facilities worldwide.. ...
We describe the design and performance of the Los Alamos VUV synchrotron radiation beamline, U3C, on the VUV ring of the National Synchrotron Light Source at Brookhaven National Laboratory. The beamline uses separate function optics to collect and focus the horizontally and vertically diverging beam. The monochromator is a grazing incidence Roland circle instrument of the extended grasshopper design (ERG). A post monochromator refocusing mirror is used to focus or collimate the diverging beam from the monochromator. The beamline control and diagnostics systems are also discussed ...
Structural biology has developed rapidly over the last decade, driven by the various genome projects around the world and by advances in the field of biomolecular crystallisation. X-ray diffraction from macromolecular crystals is used to reveal the atomic arrangement of proteins, nucleic acids and viruses. In this respect, macromolecular crystallography is a powerful tool in the drug-design process. The outstanding properties of the X-ray beams provided by synchrotron radiation sources are now essential for collecting high-quality diffraction data. Pharmaceutical companies appreciate the rapid data collection on very small crystals and at higher resolution than with conventional X-ray sources.. The ESRFs crystallography beamlines have seen a large increase in demand for beamtime from industry in recent years. Companies are also requesting faster access to the synchrotron facilities. Therefore, a data collection service was set up, whereby the user sends their frozen samples to ESRF. The ...
TY - JOUR. T1 - Structural Basis of Inhibitor Selectivity in Human Indoleamine 2,3-Dioxygenase 1 and Tryptophan Dioxygenase. AU - Pham, Khoa N.. AU - Lewis-Ballester, Ariel. AU - Yeh, Syun Ru. N1 - Funding Information: We thank Dr. Denis L. Rousseau for helpful discussions. The structural data were collected by the Lilly Research Laboratories Collaborative Access Team (LRL-CAT) beamline staff at Sector 31 of the Advanced Photon Source. This research used resources of the Advanced Photon Source, a US Department of Energy (DOE) Office of Science User Facility operated for the DOE Office of Science by Argonne National Laboratory under Contract No. DE-AC02-06CH11357. Use of the Lilly Research Laboratories Collaborative Access Team (LRL-CAT) beamline at Sector 31 of the Advanced Photon Source was provided by Eli Lilly Company, which operates the facility. This work was supported by National Institute of Health Grant GM115773 and GM126297 to S.-R.Y. Publisher Copyright: Copyright © 2019 American ...
The CAT end station of the CAT-ACT beamline at ANKA is dedicated to catalytic research using X-ray spectroscopic techniques. It will be operated by the Grunwaldt group at the Institute for Chemical Technology and Polymer Chemistry (http://www.itcp.kit.edu/grunwaldt/) and the Institute of Catalysis Research and Technology (http://www.ikft.kit.edu/234.php).. Synchrotron radiation based techniques have evolved as key speciation methods in catalysis research, especially with respect to in-situ and in-operando X-ray based characterization techniques as a basis for a rational design of heterogeneous catalysts. Knowledge of oxidation state and coordination environment of the catalytically active centers, nanoparticle morphology etc. contributed significantly to a deeper understanding of heterogeneously catalyzed reactions and serves today as a basis for the design of new catalysts and for first-principles kinetic modeling. The beamline design places emphasis on in situ X-ray Absorption Spectroscopy ...
The Stanford Synchrotron Radiation Lightsource (SSRL) at the SLAC National Accelerator Laboratory is a national synchrotron x-ray research facility funded by the U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences.
The Stanford Synchrotron Radiation Lightsource (SSRL) at the SLAC National Accelerator Laboratory is a national synchrotron x-ray research facility funded by the U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences.
The figure above depicts the s-SNOM setup used in the published work using two different sources, a tunable narrow band quantum cascade laser (QCL) and the synchrotron broadband IR beam. As an innovation brought by the research, the synchrotron setup used a classic symmetric Michelson interferometer for Fourier processing the data as an alternative to the standard asymmetric scheme typically used in s-SNOM. Better SNR related to increased optical power at the sample and higher mechanical stability highlight the instrumental advances of the research. The work explored the interferometric properties of the far-field background arising from tip-sample geometrical scattering and developed a model for retrieving the near-field phase, and consequently the absorption properties, of a variety of samples such as poly(methyl methacrylate) (PMMA), poly(dimethylsiloxane) (PDMS), explosive polymers 1,3,5-trinitroperhydro-1,3,5-triazine (RDX) and pentaerythritol tetranitrate (PETN), and Bovine Serum Albumin ...
Contacts: Peter Genzer, (631) 344-3174 | Written by Chelsea WhytePrint The University of California, Riverside issued the following release on Wednesday, Jan. 16. X-ray diffraction and microdiffraction studies for this work were conducted at beamlines X13B and X6B at the National Synchrotron Light Source, with the help of Brookhaven physicist, co-author Elaine DiMasi. For more information about Brookhavens role, contact Chelsea Whyte, [email protected], 631-344-8671, or Peter Genzer,
SPring-8 is a third-generation synchrotron radiation facility, and provides the most powerful synchrotron radiation currently available. SPring-8 is being widely opened for domestic and foreign researchers to strengthen advanced research in fundamental science and industrial applications and so forth.The Japan Synchrotron Radiation Research Institute (JASRI) is responsible for the management, operation and development of the facility.
SPring-8 is a third-generation synchrotron radiation facility, and provides the most powerful synchrotron radiation currently available. SPring-8 is being widely opened for domestic and foreign researchers to strengthen advanced research in fundamental science and industrial applications and so forth.The Japan Synchrotron Radiation Research Institute (JASRI) is responsible for the management, operation and development of the facility.
The temperature sensitivity of vaccines and therapeutic proteins forces the distribution of life-saving treatments to rely heavily on the temperature-controlled (usually 2-8 degrees C) supply and distribution network known as the cold chain. Here, using avidin as a model, we demonstrate how surface engineering could significantly increase the thermal stability of therapeutic proteins. A combination of spectroscopic (Fourier transform infrared, circular dichroism, and ultraviolet-visible) and scattering techniques (dynamic light scattering, small-angle, and wide-angle X-ray scattering) were deployed to probe the activity, structure, and stability of the model protein. Temperature-dependent synchrotron radiation circular dichroism spectroscopy was used to demonstrate a significant increase in thermal stability, with a half denaturation temperature of 139.0 degrees C and reversible unfolding with modified avidin returning to a 90% folded state when heated to temperatures below 100 degrees C. ...
The Protein Circular Dichroism Data Bank (PCDDB) is a web-based resource containing circular dichroism (CD) and synchrotron radiation circular dichroism spectral and associated metadata located at http://pcddb.cryst.bbk.ac.uk. This resource provides a freely available, user-friendly means of accessing validated CD spectra and their associated experimental details and metadata, thereby enabling broad usage of this material and new developments across the structural biology, chemistry, and bioinformatics communities. The resource also enables researchers utilizing CD as an experimental technique to have a means of storing their data at a secure site from which it is easily retrievable, thereby making their results publicly accessible, a current requirement of many grant-funding agencies world-wide, as well as meeting the data-sharing requirements for journal publications. This tutorial provides extensive information on searching, accessing, and downloading procedures for those who wish to utilize ...
Addressing global challenges. The ESRF is a centre of excellence for fundamental research, also committed to applied and industrial research. It contributes to overcoming the societal and environmental challenges facing the world.. ...
Addressing global challenges. The ESRF is a centre of excellence for fundamental research, also committed to applied and industrial research. It contributes to overcoming the global challenges facing the world.. ...
Sutherland, J. C., Dec 1 2009, Modern Techniques for Circular Dichroism and Synchrotron Radiation Circular Dichroism Spectroscopy. Wallace, B. A. & Janes, R. W. (eds.). p. 19-72 54 p. (Advances in Biomedical Spectroscopy; vol. 1).. Research output: Chapter in Book/Report/Conference proceeding › Chapter ...
The influence of strain rate on development of deformation texture under a dynamic shock compression of a 904L stainless steel was quantitatively investigated using synchrotron X-ray diffraction and crystallographic orientation distribution function (ODF) analysis. The Split-Hopkinson Pressure Bar (SHPB) technique was used to generate a high strain rate of andgt; 10(3) s(-1) for preparing the deformed samples. Starting with an almost random texture in a solution treatment condition, the deformed material developed several typical texture components, such as Goss texture and Brass texture. Compared to the texture components displayed in the state of quasi-static compression deformation, it was found that the high-speed deformation generated much weaker texture components. In combination with the change in microstructures observed by electron backscattering diffraction (EBSD) and the transmission electron microscopy (TEM) technique, the high-energy X-ray diffraction provides a powerful tool for ...
Sznitman, J; Sutter, R; Altorfer, D; Stampanoni, M; Rösgen, T; Schittny, J C (2010). Visualization of respiratory flows from 3D reconstructed alveolar airspaces using X-ray tomographic microscopy. Journal of Visualization, 13(4):337-345. ...
Comparison of synchrotron radiation and conventional X-ray microcomputed tomography for assessing trabecular bone microarchitecture of human femoral ...
Accelerators like the National Synchrotron Light Source (NSLS) II fire particles around a circular tunnel to nearly the speed of light. But as electrons curve around the ring, they lose energy in the form of light. Rather than think of this as a defect, researchers at Brookhaven National Laboratory found a way to harness this excess light and use it to understand the world at its most fundamental level. This basic research, however, can lead to remarkable and practical results. Considering the original NSLS at Brookhaven helped win two Nobel prizes, create better HIV treatments and rethink the battery, this increase in performance will likely open the door to groundbreaking new discoveries.. ...
Abstract: Background: As a novel approach to solve the protein structure, serial femtosecond crystallography (SFX) has been developed rapidly owing to the advantages of the room-temperature data collection, lower radiation damage and time-resolved study. The first X-ray free-electron laser (XFEL) based SFX experiment has offered a new method to structure determination of protein microcrystals successfully. Purpose:The aim is to introduce SFX into the widely-available third-generation synchrotron radiation (SR). Methods: The electrospinning sample delivery system is a potential method to be applied on SR. The theoretical and experimental researches on electrospinning were studied using BL17U1 beamline in Shanghai synchrotron radiation facility (SSRF). Results: A microjet containing microcrystals was produced from the liquid meniscus and controlled by an electrostatic field. The air ionization problem disturbing electrospinning in SR experiment was solved by providing vacuum condition and coaxial ...
In order to investigate FeSO4, ZnSO4 (the two of main metal compositions of Shanghai PM2.5 (particle matter with those aerodynamical diameter |2.5 mu m)) effects on acute lung injury, six solutions contained PM2.5 aerosol particles, FeSO4, ZnSO4 and their mixtures were instilled intratracheally into mouse lungs for experiment. By 2 days. after instillation, the live mice were checked in vivo by synchrotron refractive index microradiography. In addition after extracted and examined by dissection, the right lobes of lung were fixed by formalin, then imaged by synchrotron microradiography again. Corresponding parts of those lung tissues were embedded in paraffin for histopathologic study. The synchrotron X-ray microradiographs of live mouse lung showed different lung texture changes after instilled with different toxic solutions. Hemorrhage points in lung were observed more from those mice instilled by FeSO4 contained toxin solutions groups. Bronchial epithelial hyperplasia can be observed in ZnSO4
Presented here is a protocol for cell culture on silicon nitride membranes and plunge-freezing prior to X-ray fluorescence imaging with ...
A radiation-based timer for use in an implantable medical device (IMD) includes a radiation source and a radiation detection circuit. The radiation source emits radiation particles during a process referred to as radioactive decay. The radiation detection circuit detects the radiation particles emitted during the decay process and tracks the number of radiation particles detected. When the number of radiation particles detected reaches a threshold value, a timer signal is generated. In this manner, the radiation-based timer generates a timer signal as a function of the radioactive decay of the radiation source. The timer signal may be used by one or more components of the IMD for any of a number of functions, including as a wakeup trigger for a communications and/or a sensor event.
Micro-X-ray absorption near-edge structure (μ-XANES) spectroscopy has been used by several recent studies to determine the oxidation state and coordination of iron in silicate glasses. Here, we present new results from Fe μ-XANES analyses on a set of 19 Fe-bearing felsic glasses and 9 basaltic glasses with known, independently determined, iron oxidation state. Some of these glasses were measured previously via Fe XANES (7 rhyolitic, 9 basaltic glasses; Cottrell et al. 2009), while most felsic reference glasses (12) were analyzed for the first time. The main purpose of this study was to understand how small changes in glass composition, especially at the evolved end of silicate melt compositions occurring in nature, may affect a calibration of the Fe μ-XANES method.. We performed Fe μ-XANES analyses at different synchrotron radiation sources [Advanced Photon Source (APS), Argonne, U.S.A., and Angströmquelle Karlsruhe (ANKA), Germany] and compared our results to existing calibrations obtained ...
TY - JOUR. T1 - Novel rhenium(V) nitride complexes with dithiocarbimate ligands. T2 - A synchrotron X-ray and DFT structural investigation. AU - Perils, Joanne. AU - Cortezon-Tamarit, Fernando. AU - Kuganathan, Navaratnarajah. AU - Kociok-Köhn, Gabriele. AU - Dilworth, Jonathan R. AU - Pascu, Sofia I.. PY - 2018/4/24. Y1 - 2018/4/24. N2 - The application of rhenium complexes as therapeutic agents in nuclear medicine has propelled research into the chemistry of these compounds. In our effort to develop and investigate new therapeutic radiopharmaceuticals based on the complexes of rhenium we have investigated the nitride core, [ReN]2+. This work looks at the behavior of sulfonamide based dithiocarbimates towards the rhenium(V) nitride core. The aim here was to prepare anionic complexes with aromatic as well as fluorescent aromatic groups in the sulfonamide substituent located on the dithiocarbimate backbone. We envisaged that the polar sulfonamide and dianionic charge would confer solubility in ...
...SASKATOON SASKATCHEWAN Canadian Light Source (CLS) staff scientist Lu... The advantage to using microscopes with synchrotron light is that it ...The team analyzed preserved samples of healthy and diseased tissue tha...Barretts Esophagus (BE) occurs when the cells that normally line the ...,University,of,Saskatchewan,and,Canadian,Synchrotron,researchers,shed,light,on,esophageal,disease,biological,biology news articles,biology news today,latest biology news,current biology news,biology newsletters
We thank Prof. Dr. Wolfgang Baehr (University of Utah, USA) for providing us PrBP/δ expression vector. We are obliged to Ms. Ingrid Semjonow, Ms. Helena Seibel and Mr. Brian Bauer for their excellent technical assistance in purifying reagents and in protein preparations. We are grateful to Uwe Müller, Manfred Weiss and the scientific staff of the BESSY-MX/Helmholtz Zentrum Berlin für Materialien und Energie at beamlines BL14.1, BL14.2 and BL14.3 operated by the Joint Berlin MX-Laboratory at the BESSY II electron storage ring (Berlin-Adlershof, Germany) and the scientific staff of the European Synchrotron Radiation Facility (ESRF, Grenoble) at beamlines ID14-1, ID14-4, ID23-1, ID23-2, ID30A, ID30B and ID29, where the data were collected, for continuous support. This work was supported by grants from the Deutsche Forschungsgemeinschaft (SFB740 to T.M., C.M.T.S, M.H., P.S.; SFB1078-B6 to P.S.; SFB958 to C.M.T.S.), DFG Cluster of Excellence Unifying Concepts in Catalysis (Research Field D/E to ...
The penetrating power of X-rays coupled with the high flux of 3rd generation synchrotron sources makes X-ray tomography to excel among fast imaging methods . To exploit this asset of synchrotron sources is the motivation for setting up an ultra-fast tomography endstation at the TOMCAT beamline. The state of the art instruments at synchrotron sources offer routinely a temporal resolution of tens of seconds in tomography. For a number of applications, for example biomedical studies, the relevant time scales (breathing, heartbeat) are rather in the range of 0.5-2 seconds. To overcome motion artifacts when imaging such systems a new ultra-fast tomographic data acquisition scheme is being developed at the TOMCAT beamline. We can acquire a full set of projections at sub-second timescale in monochromatic or white-beam configuration. We present a feasibility study with the ultimate aim to achieve sub-second temporal resolution in 3D without significant deterioration of the spatial resolution. For the ...
In this study, the course of myofibrillogenesis in Drosophila pupae was followed by means of conventional X-ray diffraction and end-on microdiffraction. Owing to the high transmission of X-ray beams, the diffraction technique is suitable for detecting overall regularity in molecular arrangement in bulk specimens such as the thoraces of insects. With the wavelength of the X-ray used here (0.1 nm), this technique will be applicable to larger insects, including honeybees and silkworm moths. In the conventional X-ray diffraction recordings, in which the beamsize is comparable to the size of a Drosophila thorax (approx. 1 mm), the extent of development of thoracic musculature can be diagnosed with a single shot of chest X-ray. This is a non-invasive method requiring relatively low doses of X-rays and may be incorporated for routine checks of developmental status and/or quick assessment of effect of mutations on flight muscle-related genes. On the other hand, the end-on microdiffraction recording is ...
The European Synchrotron Radiation Facility Medical Research Beamline is now fully operational. One of the primary programs is the development of dual-energy transvenous coronary angiography for in vivo human research protocols. Previous work at this and other synchrotrons has been entirely devoted to the use of the dual-energy digital subtraction technique at the iodine k-absorption edge at 33.17 keV. The images are recorded in a line scan mode following venous injection of the contrast agent. Considerations of the patient dose, the dilution of the contrast agent in the pulmonary system and the arteries overlying the filled ventricles have limited the image quality. The ESRF facility was designed to allow dual- energy imaging at higher energies, for example at the gadolinium k-absorption edge at 50.24 keV. The advantages have been theoretically known for many years, with the higher energy promising higher image quality with less radiation dose. During the commissioning phase of the ESRF ...
Nanoflake/graphite Fibers EI 作者:Liu, Zhihe ;Tan, Hua ;Liu, Daobin ;Liu, Xiaobiao ;Xin, Jianping ;Xie, Junfeng ;Zhao, Mingwen ;Song, Li ;Dai, Liming ;Liu, Hong 作者机构:[Liu, Zhihe ;Liu, Hong ] Institute for Advanced Interdisciplinary Research (IAIR), University of Jinan, Shandong; 250022, China;[Liu, Daobin ;Song, Li ] National Synchrotron Radiation Laboratory CAS Hefei Science Center University of Science and Technology of China Hefei, Anhui; 230026, China;[Liu, Zhihe ;Tan, Hua ;Xin, Jianping ;Liu, Hong ] State Key Laboratory of Crystal Materials, Shandong University, Jinan; Shandong; 250100, China;[Xie, Junfeng ] College of Chemistry, Chemical Engineering and Materials Science, Shandong Normal University, Jinan; 250014, China;[Liu, Xiaobiao ;Zhao, Mingwen ] School of Physics and Microelectronics, Shandong University Jinan, Shandong; 250100, China;[Dai, Liming ] Center of Advanced Science and Engineering for Carbon (Case4carbon), Department of Macromolecular Science and Engineering, ...
Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Earth Sciences, Department of Earth Sciences. Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Earth Sciences, Department of Earth Sciences, Solid Earth Geology. ...
Synchrotron-based micro X-ray absorption spectroscopy (micro-XAS) in combination with micro X-ray fluorescence (micro-XRF) and micro X-ray diffraction (micro-XRD) are powerful tools for spatially resolved micro-scale investigations of retention processes in heterogeneous systems. We have successfully applied these techniques in the investigations of uptake processes in argillaceous rocks and hardened cement paste. Here one of the essential questions is On what mineral phase or phases is sorption occurring in the complex mineral assemblage? and Is it the same phase(s) assumed in the modeling? In some cases minor minerals may well be important. Furthermore, we were able to shine light into the alkali-aggregate reaction, which is a severe alteration process limiting the lifetime of concrete structures exposed to water or moisture ...
An initial tranche of results from day-to-day use of a robotic system for setting up 100 nl-scale vapour-diffusion sitting-drop protein crystallizations has been surveyed. The database of over 50 unrelated samples represents a snapshot of projects currently at the stage of crystallization trials in Oxford research groups and as such encompasses a broad range of proteins. The results indicate that the nanolitre-scale methodology consistently identifies more crystallization conditions than traditional hand-pipetting-style methods; however, in a number of cases successful scale-up is then problematic. Crystals grown in the initial 100 nl-scale drops have in the majority of cases allowed useful characterization of X-ray diffraction, either in-house or at synchrotron beamlines. For a significant number of projects, full X-ray diffraction data sets have been collected to 3 Šresolution or better (either in-house or at the synchrotron) from crystals grown at the 100 nl scale. To date, five structures ...
A photovoltaic device comprises an upper cell and a lower cell separated by an electrically insulating layer. The cells and the layers are fabricated as a single monolithic structure, and separate electrical contacts are provided for the upper and lower cells to allow independent extraction of current from each cell. The upper cell has a larger bandgap than the lower cell so that incident low energy photons unabsorbed and unconverted by the upper cell can propagate through to the lower cell for conversion. The two bandgaps can be selected to accommodate spectral ranges of interest. The device is incorporated into a system including two sources of photons with different wavelength ranges associated with the bandgaps of the two cells, such that each cell can convert photons from one source. One source may be the sun and the other may be a local photon source such as a thermal source. Alternatively, both photon sources may be local sources. Operation of the device can be further optimised and
The J. Bennett Johnston, Sr., Center for Advanced Microstructures and Devices (CAMD), is named for the father of its congressional sponsor, Senator J. Bennett Johnston, Jr. of Louisiana. CAMD is a synchrotron radiation research center at Louisiana State University in Baton Rouge. The mission of CAMD is to provide infrastructure for research and education in synchrotron-based science and technology. The facility was built with a $25-million grant from the U.S. Department of Energy and its operations are state-funded by LSU. The heart of the facility is a 1.3 GeV electron storage ring that was built exclusively to provide synchrotron radiation. Research in basic sciences and microfabrication is conducted by scientist and engineers from Louisiana universities, along with distinguished scientists from national and international institutions. ...
Norwegian and International Researchers can apply for the Fellowship.. Scholarship Description: The PhD project will be in the field of structural biology on a project entitled Bacterial toxins - Structure, function and molecular interactions . The project will ideally combine biophysical characterization (foremost by X-ray crystallography) with cell biological investigations. It is anticipated that the project will include a research stay at a foreign institution such as the European Synchrotron Radiation Facility (ESRF), Grenoble. The project can be expanded to involve collaborations with Michele Cascella (computational chemistry) and Kirsten Sandvig (cell biology).. Number of award(s): One PhD research fellowship is available.. Duration of award(s): The fellowship will be for a period of 4 years, with 25 % compulsory work (teaching responsibilities at the Department). Otherwise, the fellowship will be for a period of 3 years, with no compulsory work.. What does it cover? Position code 1017, ...
CHDI Foundation, Inc., a biomedical research organization exclusively focused on developing disease-modifying therapies for HD, is working with BioFocus, a drug discovery provider, to solve the structure of the active caspase-6 and in complex with inhibitors, with a view towards developing caspase-6 specific drugs. Using mosquito® Crystal for automated low-volume crystal screening, BioFocus identified crystallization conditions for apo-caspase-6 in the active state (PDB ID 3P45), in complex with the reversible inhibitor Ac-VEID-CHO (PDB ID 3P4U), as well as in complex with the irreversible inhibitor Z-VAD-FMK (PDB ID 3QNW). Optimization of the crystallization conditions of the irreversible inhibitor yielded plate-like crystals typically only 10-20 μm thick, which required synchrotron light to gain sufficient optical resolution.. ...
The DXAS beamline is an experimental station dedicated to dispersive x-ray absorption spectroscopy (acronym for DXAS) techniques, in the hard x-ray energy range (5 to 14 keV). The peculiarity of this beamline is the capability to collect absorption spectra over an extended range of photon energies without any mechanical movement of its optical elements. The DXAS is especially suited for detecting weak signals in XANES (X-ray Absorption Near-Edge Spectroscopy) and XMCD (X-ray Magnetic Circular Dichroism) experiments and for tracking time-dependent evolution of chemical reactions.. DXAS is installed on a 1.67T bending-magnet source, and it was opened to users in 2005. The beamline is comprised by the synchrotron light source, a vertically focusing bendable mirror, a bent crystal polychromator, and an area detector. The beam path over the optical elements starts when it hits the bendable mirror, used for vertical focusing as well as harmonic rejection. Then the light beam impinges onto a ...
TY - JOUR. T1 - Controlling N-doping type in carbon to boost single-atom site Cu catalyzed transfer hydrogenation of quinoline. AU - Zhang, Jian. AU - Zheng, Caiyan. AU - Zhang, Maolin. AU - Qiu, Yajun. AU - Xu, Qi. AU - Cheong, Weng Chon. AU - Chen, Wenxing. AU - Zheng, Lirong. AU - Gu, Lin. AU - Hu, Zhengpeng. AU - Wang, Dingsheng. AU - Li, Yadong. N1 - KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: This work was supported by the National Key R&D Program of China (Nos. 2018YFA0702003 and 2016YFA0202801), the National Natural Science Foundation of China (Nos. 21890383, 21671117, 21871159, and 21901135), the National Postdoctoral Program for Innovative Talents, the Shuimu Tsinghua Scholar, Science and Technology Key Project of Guangdong Province of China (No. 2020B010188002), and Beijing Municipal Science & Technology Commission (No. Z191100007219003). We thank the BL14W1 station in Shanghai Synchrotron Radiation Facility (SSRF) and 1W1B station for XAFS measurement in ...
A research project, published this week in the journal Nature, sheds light on the bizarre halszkaraptor - a dinosaur so unusual that scientists are hailing it as a new species. What is very special about it is that it looks very weird. It doesnt look like any other dinosaur that we know so far, Vincent Fernandez, a paleontologist at the European Synchrotron Radiation Facility and co-author of the study, told The Guardian. About the size of a goose, the dinosaur boasted a long tail, a curved, elegant neck and a duck-like bill. While that may seem all bird to you, the halszkaraptor is considered non-avian. Its also a close cousin to the Cretaceous Periods famously ferocious velociraptor.
TY - GEN. T1 - Microfocusing optics for hard xrays fabricated by x-ray lithography. AU - Krasnoperova, Azalia A.. AU - Chen, Zheng Guo. AU - Cerrina, Franco. AU - Difabrizio, E.. AU - Gentili, Massimo. AU - Yun, Wenbing. AU - Lai, Barry P.. AU - Gluskin, Efim S.. PY - 1995. Y1 - 1995. N2 - Lithographic techniques for fabrication of hard x-ray Fresnel zone plates are discussed. Practical results achieved at the Center for X-ray Lithography of the University of Wisconsin- Madison are presented. Fabrication technology includes replication of an e-beam written master mask into a thick photoresist by synchrotron radiation x-ray lithography, and subsequent electroplating of a metal zone plate structure using photoresist pattern as a mold.. AB - Lithographic techniques for fabrication of hard x-ray Fresnel zone plates are discussed. Practical results achieved at the Center for X-ray Lithography of the University of Wisconsin- Madison are presented. Fabrication technology includes replication of an ...
The RF gymnastics involved in the delivery of proton and lead ion bunches to the LHC can result in satellite bunches of varying intensity occupying the nominally empty RF buckets. Quantification of these satellites is crucial for bunch-by-bunch luminosity normalization as well as for machine protection. We present an overview of the longitudinal density monitor (LDM) which is the principal instrument for the measurement of satellite bunches in the LHC. The LDM uses single photon counting of synchrotron light. The very high energies reached in the LHC, combined with a dedicated undulator for diagnostics, allow synchrotron light measurements to be made with both protons and heavy ions. The arrival times of photons are collected over a few million turns, with the resulting histogram corrected for the effects of the detectors deadtime and afterpulsing in order to reconstruct the longitudinal profile of the entire LHC ring. The LDM has achieved a dynamic range in excess of 105 and a time resolution ...
TY - JOUR. T1 - Response to Comments on Structural studies of haemoglobin from pisces species shortfin mako shark (Isurus oxyrinchus) at 1.9 Å resolution by P. Ramesh et al. (2013). J. Synchrotron Rad. 20, 843-847. AU - Ramesh, Pandian. AU - Sundaresan, S. S.. AU - Sathya Moorthy, Pon. AU - Balasubramanian, M.. AU - Ponnuswamy, M. N.. PY - 2014/7. Y1 - 2014/7. UR - http://www.scopus.com/inward/record.url?scp=84903582799&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=84903582799&partnerID=8YFLogxK. U2 - 10.1107/S1600577514010285. DO - 10.1107/S1600577514010285. M3 - Letter. C2 - 24971984. AN - SCOPUS:84903582799. VL - 21. JO - Journal of Synchrotron Radiation. JF - Journal of Synchrotron Radiation. SN - 0909-0495. IS - 4. ER - ...
TY - JOUR. T1 - Liquid Structure of CO2-Reactive Aprotic Heterocyclic Anion Ionic Liquids from X-ray Scattering and Molecular Dynamics. AU - Sheridan, Quintin R.. AU - Oh, Seungmin. AU - Morales-Collazo, Oscar. AU - Castner, Edward W.. AU - Brennecke, Joan F.. AU - Maginn, Edward J.. N1 - Funding Information: Support for the work of Q.R.S. and E.J.M. was provided by the Air Force Office of Scientific Research under AFOSR award number FA9550-14-1-0306. Computational resources were provided by the Notre Dame Center for Research Computing. Claudio Margulis and Jeevapani J. Hettige are acknowledged for their help with the structure function calculations. We acknowledge time on beamline 11-ID-B at the Argonne National Laboratory Advanced Photon Source under APS General User Proposal GUP-43233. For experimental support at APS beamline 11-ID-B, we thank Dr. Olaf J. Borkiewicz and Mr. Kevin A. Beyer. E.W.C. was supported by NSF grant number CHE-1362272. J.F.B. and S.O. acknowledge financial support from ...
We have measured the stability of a variety of photodiodes exposed to 157-nm light from a pulsed excimer laser by using a radiometry beamline at the Synchrotron Ultraviolet Radiation Facility at the National Institute of Standards and Technology. The intense, pulsed laser light exposed the photodiodes, whereas the low-intensity, continuously tunable light from the synchrotron source measured changes in the characteristics of the photodiodes, such as in the responsivity and the reflectance from the surface of a photodiode. Photodiodes studied include both silicon pn-junction and Schottky-barrier types. Among these photodiodes, we found that the damage mechanism for photodiodes with SiO2-based passivating layers is mainly the buildup of SiO2-Si interface trap states. The interface trap state buildup is well known for other semiconductor devices and is generally recognized as a product induced by radiation with an energy more than the 9-eV SiO2 bandgap energy rather than the 7.9-eV energy of the ...
Diamond is the UKs national synchrotron science facility. Its shaped like a huge ring, and is a bit like a giant microscope. Diamond speeds up electrons to near light speeds, producing a light 10 billion times brighter than the sun. These bright beams are then directed off into laboratories known as beamlines; here scientists use the light to study everything from viruses and vaccines to fossils and jet engines.. Diamond is one of the most advanced scientific facilities in the world, and its pioneering capabilities are helping to keep the UK at the forefront of scientific research. Here you can read about cutting-edge scientific research taking place at the synchrotron; and find out when your next chance is to visit Diamond. So take a look around, and find out what lies within the walls of the synchrotron.. ...
The purpose of this research is to develop improved diagnostic and treatment tools for prostate cancer in humans through the use of a canine (dog) model and a synchrotron-based x-ray source for imaging and therapy at the Canadian Light Source (CLS). Novel techniques in synchrotron x-ray imaging, specifically in-line phase contrast CT (PC-CT), will be explored as a valuable method for research and clinical imaging of spontaneous canine prostatic diseases as a model for human diseases. ...
Intimately intergrown micron-scale framboidal pyrite, carbonaceous material (CM), chalcopyrite, sphalerite and cobaltite form polyframboids in prehnite-pumpellyite facies rocks of the Otago Schist, New Zealand. This study quantifies the metal contents of these polyframboids using synchrotron X-ray fluorescence (SXRF) and laser ablation inductively coupled plasma spectrometry (LA-ICP-MS). Trace elements Au, Zn, As, Mo, Co, Ni, Cu, Ag and Pb are significantly enriched in the polyframboids. The distribution of Zn most closely follows that of CM, and was probably absorbed into the structure of the polyframboids during biogenic processes. The concentrations of Au and Ag are positively corrected with the Zn concentration in the polyframboids (R2 of Au-Zn and Ag-Zn are 0.81 and 0.89, respectively.). The concentration of other trace elements, such as As, Co and Cu, which occur adjacent to Zn on elemental maps, show a weak relationship with Zn and may have been incorporated into the polyframboids during ...
Abstract: Inductively coupled plasma mass spectrometry (ICP-MS) was used to quantify the total amount of trace elements in retina from adult male Sprague-Dawley rats (n = 6). Concentration of trace elements within individual retinal areas in frozen sections of the fellow eye was established with the use of two methodologies: (1) particle-induced X-ray emission (PIXE) in combination with 3D depth profiling with Rutherford backscattering spectrometry (RBS) and (2) synchrotron X-ray fluorescence (SXRF) microscopy. The most abundant metal in the retina was zinc, followed by iron and copper. Nickel, manganese, chromium, cobalt, selenium and cadmium were present in very small amounts. The PIXE and SXRF analysis yielded a non-homogenous pattern distribution of metals in the retina. Relatively high levels of zinc were found in the inner part of the photoreceptor inner segments (RIS)/outer limiting membrane (OLM), inner nuclear layer and plexiform layers. Iron was found to accumulate in the retinal ...
An interview with Dr. Gerry McDermott of the National Center for X-ray Tomography. Dr. Biology tours the synchrotron that is also called the giant monster. Dr. Biology learns how the football sized facility is used to power a new kind of microscope.. Content Info , Transcript ...
Porphyrin-based materials are prime candidates for solar energy harvesting applications. New compounds incorporating the porphyrin core, which exhibit the columnar liquid crystal (LC) phase, were synthesized as they offer a route to obtaining defect-free large area monodomain films. The structure of the phases exhibited by these materials has been probed by synchrotron X-ray diffraction with a microfocus (14ím x14 ím) beam. Exploiting the multidomain nature (i.e., having differently oriented crystal axes) of a thin glass cell, it was possible to obtain complete structural information without the need to have one single macroscopic crystal, which is normally difficult to obtain. The results confirmed the existence of the isotropic, discotic (columnar) LC, and discotic-ordered LC phases in these materials. The optical microscopic work demonstrates how macroscopic control of columnar orientations is achieved by manipulating the LC film thickness, substrate preparation, and the thermal annealing process.
No topic is more fundamental to Chemistry than the nature of the chemical bond. In crystalline solids, the chemical bond gives rise to the electronic bandstructure of the material, this then determines whether the material is a metal, semiconductor, semi-metal, etc.; it determines the optical characteristics, the transport properties and the usefulness of any given crystalline solid. Novel x-ray spectroscopic techniques are now available to probe the electronic structure of crystalline solids, element-by-element and even state-by-state. These synchrotron radiation based methods will be applied to a particular class of crystalline solids to study more fully their basic electronic structure. The electronic structure of a class of crystalline solids will be investigated through a novel application of polarisation dependent synchrotron radiation based resonant soft x-ray emission spectroscopy and x-ray absorption spectroscopies to obtain element specific, symmetry and state selective measurements of ...
Purpose: We have developed a gated spot scanning proton beam therapy system with real-time tumor-tracking. This system has the ability of multiple-gated irradiation in a single synchrotron operation cycle controlling the wait-time for consecutive gate signals during a flat-top phase so that the decrease in irradiation efficiency induced by irregular variation of gate signal is reduced. Our previous studies have shown that a 200 ms wait-time is appropriate to increase the average irradiation efficiency, but the optimal wait-time can vary patient by patient and day by day. In this research, we have developed an evaluation system of the optimal wait-time in each irradiation based on the log data of the real-time-image gated proton beam therapy (RGPT) system. Methods: The developed system consists of logger for operation of RGPT system and software for evaluation of optimal wait-time. The logger records timing of gate on/off, timing and the dose of delivered beam spots, beam energy and timing of ...
Reduction of seed dormancy mechanisms, allowing for rapid germination after planting, is a recurrent trait in domesticated plants, and can often be linked to changes in seed coat structure, in particular thinning. We report evidence for seed coat thinning between 2,000 BC and 1,200 BC, in southern Indian archaeological horsegram (Macrotyloma uniflorum), which it has been possible to document with high precision and non-destructively, through high resolution x-ray computed tomography using a synchrotron. We find that this trait underwent stepped change, from thick to semi-thin to thin seed coats, and that the rate of change was gradual. This is the first time that the rate of evolution of seed coat thinning in a legume crop has been directly documented from archaeological remains, and it contradicts previous predictions that legume domestication occurred through selection of pre-adapted low dormancy phenotypes from the wild.
See first link about a synchrotron projection TV, because we need something like that light-source here, and see the second link about carbon bicarbonate, because it provides the background chemistry that this Idea is about (and sulfur is mentioned in an annotation, too!).. OK, the main problem with making carbon bicarbonate is that the carbon atom is a quite-small atom (significantly smaller than oxygen). I suspect this is the main reason why there is no such thing as poly-CO2 (see link) except under extreme pressure. Therefore, even if we could catalyze the formation of carbon bicarbonate, with its central carbon surrounded by and single-bonded with 4 oxygen atoms, it probably could not be expected to persist.. Sulfur, however, is nicely different. While not as plentiful as carbon, it could be plentiful ENOUGH (see link). Certainly it is routinely extracted from carbon-containing fossil fuels (to mostly prevent acid rain). It is a much larger atom than carbon (significantly larger than ...
Baking the perfect loaf of bread is both a science and an art, so researchers are using Canadas only synchrotron to look at the way bubbles form in bread dough to understand what makes the perfect loaf and how gluten-free ...
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I am a dinosaur enthusiast and have been aware of Noddy for some time, and I find it interesting that you mention the time lapse of the fossil being presented at the Australian Synchrotron. Just wondering, is the fossil still on display there, and is there anywhere that video can be seen? I understand if this was all exclusive, but since I have been interested in this dinosaur for quite some time (I remember Tom and Pat Vickers-Rich bringing it up when they were down at the Otways near Dinosaur Cove, and they mentioned some very intriguing features), I would appreciate it if there is any information I can get from anywhere, or even just any info on when it could become available if it isnt. If you want to reply, just do so on this page and I will check it when I can (no need to rush it or anything ...
By Kimberly Parker, special correspondent for Cross-check. [Editors Note: I recently forced students in my Seminar on Science Writing at Stevens Institute of Technology to write short responses to my book The End of War. Kimberly Parker, a sophomore majoring in mathematics, submitted the following essay, which so impressed and heartened me that Im sharing it with readers of this blog. John Horgan]. Our class was recently asked whether or not we felt particle physics research should receive public funding. The majority of us were opposed, our reasons being that such research has no practical value. An instrument as sophisticated and expensive as a particle collider is surely a waste of a nations resources.. So it might come as a surprise that plans to build a synchrotron particle collider in Jordan have received overwhelming support from countries in the Middle East, including Iran, Pakistan, the Palestinian Authority and Israel. Scientific discovery is not the only goal being pursued. Those ...
A well-preserved dinosaur skeleton from Mongolia unites an unexpected combination of features that defines a new group of semi-aquatic predators related to Velociraptor. Detailed 3-D synchrotron analysis allowed an international team of researchers to present the bizarre 75-million-year-old predator, named Halszkaraptor escuilliei. The study not only describes a new genus and species of bird-like dinosaur that lived in Mongolia but also sheds light on an unexpected amphibious lifestyle for raptorial dinosaurs ...
SLACs meeting facilities also provided a venue for the Homebrew Computer Club and other pioneers of the home computer revolution of the late 1970s and early 1980s. In 1984 the laboratory was named an ASME National Historic Engineering Landmark and an IEEE Milestone.[7]. SLAC developed and, in December 1991, began hosting the first World Wide Web server outside of Europe.[8]. In the early-to-mid 1990s, the Stanford Linear Collider (SLC) investigated the properties of the Z boson using the Stanford Large Detector. As of 2005, SLAC employed over 1,000 people, some 150 of whom were physicists with doctorate degrees, and served over 3,000 visiting researchers yearly, operating particle accelerators for high-energy physics and the Stanford Synchrotron Radiation Laboratory (SSRL) for synchrotron light radiation research, which was indispensable in the research leading to the 2006 Nobel Prize in Chemistry awarded to Stanford Professor Roger D. Kornberg.[9]. In October 2008, the Department of Energy ...
SLACs meeting facilities also provided a venue for the Homebrew Computer Club and other pioneers of the home computer revolution of the late 1970s and early 1980s. In 1984 the laboratory was named an ASME National Historic Engineering Landmark and an IEEE Milestone.[7] SLAC developed and, in December 1991, began hosting the first World Wide Web server outside of Europe.[8] In the early-to-mid 1990s, the Stanford Linear Collider (SLC) investigated the properties of the Z boson using the Stanford Large Detector. As of 2005, SLAC employed over 1,000 people, some 150 of whom were physicists with doctorate degrees, and served over 3,000 visiting researchers yearly, operating particle accelerators for high-energy physics and the Stanford Synchrotron Radiation Laboratory (SSRL) for synchrotron light radiation research, which was indispensable in the research leading to the 2006 Nobel Prize in Chemistry awarded to Stanford Professor Roger D. Kornberg.[9] In October 2008, the Department of Energy ...
TY - JOUR. T1 - The Structural Determinants Accounting for the Broad Substrate Specificity of the Quorum Quenching Lactonase GcL. AU - Bergonzi, Celine. AU - Schwab, Michael. AU - Naik, Tanushree. AU - Elias, Mikael H. N1 - Funding Information: This work was supported by the MnDrive Initiative, and BARD grant IS-4960-16 FR to M.E. This work was also prepared by M.E. using federal funds under award NA18OAR4170101 from Minnesota Sea Grant, National Sea Grant College Program, National Oceanic and Atmospheric Administration, U.S. Department of Commerce. The statements, findings, conclusions, and recommendations are those of the authors and do not necessarily reflect the views of NOAA, the Sea Grant College Program or the U.S. Department of Commerce. This paper is journal reprint no. JR659 of the Minnesota Sea Grant College Program. We thank the Advanced Photon Source and beamline staff for access and support (23 ID-B and 23 ID-D). Publisher Copyright: © 2019 Wiley-VCH Verlag GmbH & Co. KGaA, ...