Self-filling blind loops of rat jejunum exhibit hyperregenerative transformation of the mucosa. We used this experimental model to characterise mechanisms, which may occur under similar conditions in man (stagnant loop syndrome). Epithelial and subepithelial resistance were measured in the Ussing-chamber by voltage divider ratio measurements after positioning a microelectrode between epithelium and subepithelial tissue layers. In the blind loop, epithelial resistance increased from 8 +/- 1 to 23 +/- 1 omega cm2 and subepithelial resistance from 39 +/- 4 to 86 +/- 8 omega cm2 as compared with control jejunum. The increase in the subepithelial resistance was paralleled anatomically by an increase in the thickness of the subepithelial tissue layers from 63 +/- 4 microns to 177 +/- 19 microns. Ultrastructural analysis of the tight junction area by freeze fracture electron microscopy revealed an increase in the total junctional 'depth' in the crypts from 243 +/- 9 nm in control jejunum to 396 +/- 17 ...

Diagnosing gingival hyperplasia is important because there are several other forms of gingival enlargement that you must differentiate. For example, productive tumors of bone and cysts may cause the same appearance. Tooth resorption disease is a condition commonly seen in cats that also causes expansion of the gingival bone, resulting in a similar appearance. Gingival hyperplasia is by definition noninflammatory, but concurrent periodontal disease can cause inflammation to occur as a secondary process. Dental x-rays are often needed in order to help rule out potentially serious underlying medical conditions. A definitive diagnosis of gingival hyperplasia can be made only by biopsy and a microscopic examination.. There are two ways of treating gingival hyperplasia, medical and surgical. The simplest form of medical treatment is to stop any medications that are known to cause the disease. Unfortunately, in the majority of cases these medications are necessary to sustain a good quality of life in ...

Proteus syndrome (PS) is a sporadically occurring hamartomatous disorder associated with irregular asymmetric overgrowth of multiple body tissues and cell lineages. Most malformations in patients with Proteus syndrome have a mesodermal origin.

Looking for online definition of eunuchoid gigantism in the Medical Dictionary? eunuchoid gigantism explanation free. What is eunuchoid gigantism? Meaning of eunuchoid gigantism medical term. What does eunuchoid gigantism mean?

Congenital generalized terminal hypertrichosis is a rare disease, especially when associated with gingival hyperplasia. Congenital hypertrichosis can be a clinical feature of several syndromes, so these patients must be studied by a multidisciplinary team that should include a dermatologist, geneticist, psychologist, odontologist, and an endocrinologist. We report a 7-year-old girl with congenital generalized hypertrichosis and gingival hyperplasia, and analyze the clinical approach, differential diagnosis, and treatment.

Background materials are available, below, for the announcement of the discovery of the mutation that causes Proteus Syndrome. The findings are published in the July 27, 2011 early online edition of The New England Journal of Medicine.. ...

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The Beckwith-Wiedemann syndrome, originally described by Beckwith in 1963 and Wiedemann in 1964, included congenital anomalies such as macroglossia, exomphalos, postnatal somatic gigantism, severe hypoglycemia, abdominal wall defect, capillary nevus flameus and hemihypertrophy. Macroglossia is the most common manifestation of Beckwith-Wiedemann syndrome, with studies reporting between 82 and 95 percent of the cases. Macroglossia may cause the upper airway obstruction, deglutition difficulty, articulation interference and protrusion of dentoalveloar structures resulting in anterior open bite and a mandibular prognathism. We experienced a 5 month-old male with upper airway obstruction, deglutition difficulty and recurrent upper airway infection due to macroglossia associated with Beckwith-Wiedemann syndrome and significant improvement in respiration, feeding and oral competence at 14 months follow-up after rhomboid resection and primary closure of tongue. ...

OBJECTIVES The purpose of the present study was to analyse transcriptomes and mRNA expression levels for specific genes in calcium-channel blocker-induced gingival overgrowth (GO) tissues. DESIGN Eight gingival tissues samples (from both GO negative and positive sites) were harvested from four GO patients for microarray analyses. Twelve candidate genes were selected for further quantitative real time reverse transcription-polymerase chain reaction (qRT-PCR) analyses. Ten GO tissues from periodontitis patients and ten control gingival tissues from healthy subjects were compared by qRT-PCR. Mann-Whitney U-test was used for statistical evaluation. RESULTS In GO positive tissues, 163-1631 up-regulated and 100-695 down-regulated genes were identified with more than two-fold changes compared with GO negative tissues amongst patients by microarray experiments. No commonly expressed genes amongst the eight sets of microarray data were found. The clustering analysis confirmed that the entire transcriptome

TY - JOUR. T1 - The two-domain hypothesis in Beckwith-Wiedemann syndrome. T2 - Autonomous imprinting of the telomeric domain of the distal chromosome 7 cluster. AU - Cerrato, Flavia. AU - Sparago, Angela. AU - Di Matteo, Ines. AU - Zou, Xiangang. AU - Dean, Wendy. AU - Sasaki, Hiroyuki. AU - Smith, Paul. AU - Genesio, Rita. AU - Bruggemann, Marianne. AU - Reik, Wolf. AU - Riccio, Andrea. PY - 2005/2/15. Y1 - 2005/2/15. N2 - A large cluster of imprinted genes is located on the mouse distal chromosome 7. This cluster is well conserved in humans and its dysregulation results in the overgrowth- and tumour-associated Beckwith-Wiedemann syndrome. Two imprinting centres (IC1 and IC2) controlling different sets of genes have been identified in the cluster, raising the hypothesis that the cluster is divided into two functionally independent domains. However, the mechanisms by which imprinting of genes in the IC2 domain (e.g. Cdkn1c and Kcnq1) is regulated have not been well defined, and recent evidence ...

TY - JOUR. T1 - A kalciumcsatorna-blokkolok okozta inyhyperplasia. AU - Keglevich, T.. AU - Benedek, E.. AU - Gera, I.. PY - 1999/5/3. Y1 - 1999/5/3. N2 - The prevalence of the nifedipine-induced gingival hyperplasia rang from 3-83% in dental literature. The pathomechanism of the nifedipine-induced gingival hyperplasia is not clearly understood, but some data shows a correlation between the dialy dose, the duration of treatment and the gingival overgrowth. Oral hygiene seems to play a decisive role in the development of gingival enlargement. The present findings, and substantial evidences from the dental literature, indicate that the gingival enlargement can be successfully controlled even under the continuous nifedipine administration by meticulous professional and individual oral hygiene.. AB - The prevalence of the nifedipine-induced gingival hyperplasia rang from 3-83% in dental literature. The pathomechanism of the nifedipine-induced gingival hyperplasia is not clearly understood, but some ...

Simpson-Golabi-Behmel syndrome is an X-linked condition characterized by pre- and postnatal overgrowth, coarse facies, congenital heart defects, and other congenital abnormalities (Xuan et al., 1999). It shows phenotypic similarities to Beckwith-Wiedemann syndrome (BWS; 130650), another overgrowth syndrome. See also Simpson-Golabi-Behmel syndrome type 2 (SGBS2; 300209), which has been associated with a mutation in the CXORF5 gene (300170) on chromosome Xp22. (312870) ...

Hypercementosis is an idiopathic, non-neoplastic condition characterized by the excessive buildup of normal cementum (calcified tissue) on the roots of one or more teeth. A thicker layer of cementum can give the tooth an enlarged appearance, which mainly occurs at the apex or apices of the tooth. It is experienced as an uncomfortable sensation in the tooth, followed by an aching pain. It may be noted on radiographs as a radiopaque (or lighter) mass at each root apex. Can be caused by many things. A way to remember the causes is "PIG ON TAP" Local factors- Occlusal Trauma Trauma Non-functional tooth Unopposed tooth (and impacted teeth, embedded teeth, teeth without antagonists) Systemic factors- Idiopathic Pituitary Gigantism Paget's Disease Acromegaly Periapical granuloma Arthritis Calcinosis Rheumatic fever It may be one of the complications of Paget's disease of bone in the form of generalized hypercementosis. It may also be a compensatory mechanism in response to attrition to increase ...

Gingival enlargement, (also termed gingival overgrowth, hypertrophic gingivitis, gingival hyperplasia, or gingival hypertrophy, and sometimes abbreviated to GO), is an increase in the size of the gingiva (gums). It is a common feature of gingival disease. Gingival enlargement can be caused by a number of factors, including inflammatory conditions and the side effects of certain medications. The treatment is based on the cause. A closely related term is epulis, denoting a localized tumor (i.e. lump) on the gingiva. The terms gingival hyperplasia and gingival hypertrophy have been used to describe this topic in the past. These are not precise descriptions of gingival enlargement because these terms are strictly histologic diagnoses, and such diagnoses require microscopic analysis of a tissue sample. Hyperplasia refers to an increased number of cells, and hypertrophy refers to an increase in the size of individual cells. As these identifications obviously cannot be performed with a clinical ...

Abstract: Hyaline Fibromatosis Syndrome (HFS) is a rare autosomal recessive disorder affecting primarily skin and mucous membranes. Skin appears thickened with subcutaneous nodules, associated with swollen joint contractures, red hyperpigmentation and gingival hyperplasia. Additional findings include osteopenia and osteoporosis, and the affected children are susceptible to infections and protein losing enteropathy (1). Histopathology of skin lesions shows proliferation of spindle-shaped cells, embedded in a homogeneous hyaline-like material, and biochemical alterations in type I and VI collagens as well as in glycosaminoglycans have been reported (2, 3). Initially, infantile systemic hyalinosis and juvenile systemic hyalinosis were considered as two distinct entities on the basis of time of onset. However, subsequent work demonstrated that both forms of hyalinosis were caused by mutations in the CMG2 gene (also known as ANTXR2), indicating that these disorders are allelic and part of the same ...

A mental disorder characterized by arrested or incomplete mental development, with onset before age 18, leading to significantly below-average intellectual functioning (specifically, IQ below 70), accompanied by deficits in adaptive functioning in such areas as interpersonal communication, self-care, home living, social skills, use of public amenities, self-direction, scholastic or academic performance, work, leisure, health, or safety. According to the World Health Organization, an IQ between 50 and 70 is approximately indicative of mild mental retardation, 35-50 moderate mental retardation, 20-35 severe mental retardation, and below 20 profound mental retardation. See cerebral gigantism, cerebral palsy, cretinism, cri du chat, Down's syndrome, foetal alcohol syndrome, fragile X syndrome, Hurler's syndrome, idiot savant, Klinefelter's syndrome, Lesch-Nyhan syndrome, macrocephaly, microcephaly, mild mental retardation, moderate mental retardation, phenylketonuria, profound mental retardation, ...

Overgrowth syndromes in children constitute a group of rare disorders that are typical of tissue hypertrophy. Individual overgrowth syndromes have been shown to overlap with regard to clinical and radiologic features. The details of the genetic bases of these syndromes are unfolding. Any of the three embryonic tissue layers may be involved.The syndromes may manifest in localized or generalized tissue overgrowth. Latitudinal and longitudinal growth may be affected. Nevertheless, the musculoskeletal features are central to the diagnosis of some syndromes such as Proteus syndrome. The time of presentation of children with overgrowth syndromes is an important contributor to the differential diagnosis. Children with some overgrowth syndromes such as Klippel-Trenaunay-Weber syndrome can be readily detectable at birth. In contrast other overgrowth syndromes such as Proteus syndrome usually present in the postnatal period characteristically between the 2nd and 3rd year of life. In general, children with ...

Gingival Enlargement is a term used to describe Gingival Hypertrophy or Gingival Hyperplasia which is a proliferative fibrous lesion of the Gingiva which causes esthetic and functional concerns to the patient. Drug induced Gingival enlargement is a chronic condition where prolonged use of certain Drugs or medicines leads to Gingival enlargement as aside effect. Due [&hellip

TY - JOUR. T1 - Esophageal Mucocele. T2 - A Complication of Blind Loop Esophagus. AU - Kamath, M. Vinayak. AU - Ellison, Robert G.. AU - Rubin, Joseph W.. AU - Moore, H. Victor. AU - Pai, Ganesh P.. N1 - Copyright: Copyright 2017 Elsevier B.V., All rights reserved.. PY - 1987. Y1 - 1987. N2 - Mucocele of the bypassed esophagus is an unusual complication of esophageal replacement and has been described only in isolated reference. This report is based on our experience with 6 patients in whom a mucocele developed following esophageal replacement. Esophageal replacement was performed on 37 patients over a 10-year period at the Medical College of Georgia Hospital. A symptomatic mucocele requiring excision developed in 3 patients with achalasia, 1 with congenital tracheoesophageal fistula, 1 with esophageal atresia, and 1 with inflammatory stricture. Conduits used included stomach (4), reversed gastric tube (1), and colon (1). Our experience indicates that conversion of a closed-loop esophagus into a ...

The Small Intestine Bacterial Overgrowth (SIBO) Breath Test provides valuable information in the diagnosis of small bowel overgrowth of bacteria, otherwise known as SIBO. Small Intestine Bacterial Overgrowth describes a condition in which bacteria from the large intestine have migrated to the small intestine. SIBO can also occur when bacteria native to the small intestine have simply overgrown. Using a breath test to diagnose SIBO is simple, non-invasive and inexpensive. A breath test specifies which gases are present, in addition to the location and severity of bacterial overgrowth.. With lactulose, there is greater ability to diagnose overgrowth in the distal end of the small intestine, which is thought to be most common. With the glucose challenge, absorption occurs faster so the test more accurately diagnoses proximal overgrowth, which is considered more specific to the bacteria of concern. While clinicians and researchers alike debate which method is superior for SIBO testing, we know that ...

Gingival enlargement is one of the most common soft tissue problems associated with fixed orthodontic treatment. The presence of orthodontic appliances impedes oral hygiene measures and alters the oral microbial ecosystem to a more pathogenic oral biofilm. Subsequent accumulation of plaque can contribute to development of chronic periodontal inflammation and can progress to gingival enlargement. Gingival enlargement inhibits hygiene measures, slows down orthodontic tooth movement and cause aesthetic and functional problems. Management of gingival enlargement by non-surgical periodontal treatment is considered to be most important and effective. Optimal plaque control can be maintained by meticulous brushing, flossing and professional scaling. However, motivation of maintaining oral hygiene can be disappointing in some patients. In cases that the enlarged gingivae became fibrous, surgical treatment can be considered.. Traditionally, gingivectomy was performed using scalpel under local ...

Simpson-Golabi-Behmel syndrome (SGBS) is an X-linked syndrome characterized by pre- and postnatal overgrowth (gigantism), which clinically resembles the autosomal Beckwith-Wiedemann syndrome (BWS). Deletions and translocations involving the glypican-3 gene (GPC3) have been shown to be associated with SGBS. Occasionally, these deletions also include the glypican-4 gene (GPC4). Glypicans are heparan sulfate proteoglycans which have a role in the control of cell growth and cell division. We have examined the mutational status of the GPC3 and GPC4 genes in one patient with Perlman syndrome, three patients with overgrowth without syndrome diagnosis, ten unrelated SGBS-patients and 11 BWS patients. We identified one SGBS patient with a deletion of a GPC3 exon. Six SGBS patients showed point mutations in GPC3. One frameshift, three nonsense, and one splice mutation predict a loss-of-function of the glypican-3 protein. One missense mutation, W296R, changes an amino acid that is conserved in all ...

Although a known life-threatening complication of achondroplasia, the AAP guidelines in the timing, mode of imaging, and interpretation of the test results are poorly delineated. A series of patients were evaluated under a clinical protocol and the sleep study results were carefully analyzed to reveal a unique pattern that will likely help in the determination of the severity of central sleep apnea in this patient population.. Zarate YA, Mena R, Martin LJ, Steele P, Tinkle BT, Hopkin RJ (2009). Experience with hemihyperplasia and Beckwith-Wiedemann syndrome surveillance protocol. Am J Med Genet 149A:1691-7.. Leslie ND, Tinkle BT, Strauss AW, Shooner K, Zhang K (2009). "Very long chain acylcoenzyme A dehydrogenase deficiency" in: GeneReviews at GeneTests: Medical Genetics Information Resource [database online]. Copyright, University of Washington, Seattle, 1997-2010. Available at http://www.genetests.org.. Mattheis PJ, Hickey F, Tinkle BT, Hopkin R (2008). Prenatal diagnosis: beyond decisions ...

UOC di Otorinolaringoiatria, Azienda Ospedaliera di Rilievo Nazionale e di Alta Specializzazione di Caserta. ABSTRACT. Klippel-Trenaunay syndrome (KTS) is a rare congenital disorder characterized by capillary malformations (port-wine stains or flat haemangiomas), soft tissue and bone hypertrophy, large varicose veins. Intracranial vascular malformations are very rare. The Authors report a case of a 4 year old girl with KTS, suffering from anacusis in the left ear and severe sensorineural hearing loss in the right ear, who underwent cochlear implantation; in our case angiomatous formations were located inside the temporal bone, one of these adherent to the vertical portion of the facial nerve.. INTRODUCTION. In 1900 Maurice Klippel and Paul Trenaunay were the first to describe a rare angio-osteoipertrofica syndrome characterized by symptom triad: capillary malformations (port-wine stains or flat hemangiomas), soft tissue and bone hypertrophy, large varicose veins (1, 2). It typically affects one ...

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A preauricular sinus (also known as a congenital auricular fistula, a congenital preauricular fistula, a Geswein hole, an ear pit, or a preauricular cyst) is a common congenital malformation characterized by a nodule, dent or dimple located anywhere adjacent to the external ear. Frequency of preauricular sinus differs depending the population: 0.1-0.9% in the US, 0.9% in the UK, and 4-10% in Asia and parts of Africa. Comparative frequency is known to be higher in Africans and Asians than in Caucasians. Preauricular sinuses are inherited features, and most often appear unilaterally. They are present bilaterally in 25-50% of cases.[citation needed] Preauricular sinuses and cysts result from developmental defects of the first and second pharyngeal arches. This and other congenital ear malformations are sometimes associated with renal anomalies. They may be present in Beckwith-Wiedemann syndrome, and in rare cases, they may be associated with branchio-oto-renal syndrome.[citation needed] ...

Bacterial overgrowth syndrome. Merck Manual Professional Version website. Available at: http://www.merckmanuals.com/professional/gastrointestinal-disorders/malabsorption-syndromes/bacterial-overgrowth-syndrome. Updated May 2016. Accessed October 3, 2017.. Bures J, Cyrany J, Kohoutova D, et al. Small intestinal bacterial overgrowth syndrome. World J Gastroenterol. 2010;16(24):2978-2990.. Lactose and glucose hydrogen breath test. Cleveland Clinic website. Available at: https://my.clevelandclinic.org/health/articles/lactose-and-glucose-hydrogen-breath-test. Accessed October 3, 2017.. Lin H. Small intestinal bacterial overgrowth. JAMA. 2004;292(7):852-858.. Short bowel syndrome. EBSCO DynaMed Plus website. Available at: http://www.dynamed.com/topics/dmp~AN~T115699/Short-bowel-syndrome . Updated May 6, 2014. Accessed October 3, 2017. Vanderhoof J, Young R, Murray N, Kaufman SS. Treatment strategies for small bowel bacterial overgrowth in short bowel syndrome. J Pediatr Gastroenterol Nutr. ...

Habibeddine, S, Khadir, K, Azzouzi, S, Skalli, S, Lakhdar, H. "Fibromatose hyaline juvénile : Atteinte de 2 jumeaux". Ann Dermatol Venereol. vol. 130. 2003. pp. 43-6. Juvenile hyaline fibromatosis review and report of two individuals.). Mancini, GM, Stojanov, L, Willemsen, R, Kleijer, WJ, Huijmans, HG, van Diggelen, OP. "Juvenile hyaline fibromatosis: clinical heterogenity in three patients". Dermatology. vol. 198. 1999. pp. 18-25. (Case report of three individuals with juvenile hyaline fibromatosis and the different phenotypic expression.). Criado, GR, Gonzalez-Meneses, A, Canadas, M, Rafel, E, Yanes, F, De Terreros, IG. "Infantile systemic hyalinosis: a clinicopathological study". Am J Med Genet A.. vol. 129. 2004. pp. 282-5. (Review and discussion of the characteristics of infantile systemic hyalinosis.). Al-Najjadah, I, Bang, RL, Ghoneim, IE, Kanjoor, JR. "Infantile systemic hyalinosis". J Craniofac Surg. vol. 14. 2003. pp. 719-23. (Review of infantile systemic hyalinosis from the ...

This study will examine the effect of pegvisomant on growth hormone excess in patients with McCune-Albright syndrome (MAS). Patients with this disease have polyostotic fibrous dysplasia-a condition in which areas of normal bone are replaced with fibrous growth similar to scar tissue, abnormal skin pigmentation (birth marks) and precocious (early) puberty. About 10 percent of patients have excess growth hormone (GH). GH stimulates the production of another hormone called insulin-like growth factor 1 (IGF-1). Together, GH and IGF-1 affect bone growth. The excess of these hormones in MAS can cause overgrowth of the bones of the face, hands and feet, excess sweating, or increased height.. Pegvisomant is a synthetic drug that binds to cell receptors where GH would normally bind, thus preventing the naturally occurring hormone from stimulating IGF-1 and bone growth as it normally would. This study will see if pegvisomant will reduce blood levels of IGF-1 and mitigate the effects of growth hormone ...

Overgrowth Syndrome | Learn more about Overgrowth Syndrome | Meaning of Overgrowth Syndrome | Description of Overgrowth Syndrome | Details of Overgrowth Syndrome | Article on Overgrowth Syndrome | Essay on Overgrowth Syndrome | Definition of Overgrowth Syndrome | Infospaze

DOI: 10.11607/prd.00.0824 Cultured gingival dermal substitute (CGDS), composed of gingival fibroblasts and matrix and fabricated using tissue-engineering techniques, has been used for root coverage procedures. Fourteen sites from four patients with ≥ 2 mm of Miller Class I or II facial gingival tissue recession were treated. The autologous CGDS sheet, prepared prior to surgical treatment, was grafted over the teeth with gingival recession and then covered with a coronally positioned flap. Vertical and horizontal recession was measured at baseline (prior to the surgical procedure) and 13 to 40 weeks (average: 30.7 9.6 weeks) after surgery. The average vertical and horizontal root coverage after surgery was 79.1% 25.7% and 75.2% 31.4%, respectively. Moreover, there was a significant increase of keratinized and attached gingival tissue at the final clinical evaluation compared with preoperative measurements (P < .05). These results demonstrate CGDS as a promising grafting material for use with ...

McCune-Albright syndrome (MAS) is a rare, heterogenous, clinical condition caused by a rare genetic mutation. The disorder is more common in females and is characterized by a triad of cutaneous, bone and endocrine abnormalities. We describe a girl patient with MAS having precocious puberty and multiple cafe-au-lait macules and deforming polyostotic fibrous dysplasia of bone. Clinical presentation and X-ray finding were strongly diagnostic for MAS, Patients with McCune-Albright syndrome reach the adult age with a significant burden of the disease that continuously reduces their quality of life. Skeletal deformities, fractures, hyperthyroidism, and hyperestrogenism are just few of the many challenges in the management of these patients. These disorders with close observation and early detection can be controlled.

TY - JOUR. T1 - Cyclosporin-A okozta súlyos ínyduzzanattal társuló parodontitis kezelése rendszeres mechanikus plakk-kontrollal vesetransplantált betegen (Esetismertetés).. AU - Keglevich, Tibor. AU - Windisch, Péter. AU - Gera, István. PY - 2002/2. Y1 - 2002/2. N2 - A clinical case of a middle-aged kidney transplanted woman is presented. The woman has been taking Cyclosporin-A for over 13 years and has had advanced periodontitis and severe gingival swellings and gingival inflammation. The kidney transplant patient was treated and followed up for approx. four years. The treatment protocol included very thorough mechanical scaling and root planing, oral hygienic instructions and the regular professional maintenance program resulted in complete remission of the gingival overgrowth and stabilization of the periodontal condition. The gingival and periodontal conditions showed a continuing improvement over the time despite of the continuous CSA administration.. AB - A clinical case of a ...

Looking for online definition of McCune-Albright disease in the Medical Dictionary? McCune-Albright disease explanation free. What is McCune-Albright disease? Meaning of McCune-Albright disease medical term. What does McCune-Albright disease mean?

en] OBJECTIVE: To characterize, among European and Han Chinese populations, the genetic predictors of maculopapular exanthema (MPE), a cutaneous adverse drug reaction common to antiepileptic drugs. METHODS: We conducted a case-control genome-wide association study of autosomal genotypes, including Class I and II human leukocyte antigen (HLA) alleles, in 323 cases and 1,321 drug-tolerant controls from epilepsy cohorts of northern European and Han Chinese descent. Results from each cohort were meta-analyzed. RESULTS: We report an association between a rare variant in the complement factor H-related 4 (CFHR4) gene and phenytoin-induced MPE in Europeans (p = 4.5 x 10(-11); odds ratio [95% confidence interval] 7 [3.2-16]). This variant is in complete linkage disequilibrium with a missense variant (N1050Y) in the complement factor H (CFH) gene. In addition, our results reinforce the association between HLA-A*31:01 and carbamazepine hypersensitivity. We did not identify significant genetic associations ...

The older a horse gets, the more likely it is to develop Cushing's Disease. The symptoms of the disease are variable and some are much more noticeable than others. 50% of horses with Cushing's Disease will suffer from recurrent bouts of laminitis. This is a severe and debilitating condition involving inflammation and weakness of the hoof. Abnormal hair growth is another clinical sign of Cushing's Disease, with affected horses displaying a long, curly coat that looks as though it's been permed. The coat will typically grow thicker, paler and lose its shine.. Besides this, there are several other symptoms that could point towards Cushing's Disease. These include:. - Increased thirst and hunger. If your horse is put to field, recognising increased thirst may be difficult, especially if you use a self-filling water trough. Because of increased thirst, your horse is also likely to urinate more frequently which, again, is difficult to monitor.. - Muscle wasting and weight loss can also be a sign of ...

What Really Causes Acid Reflux and GERD? Home / acid reflux, acid reflux drugs, Diet and Digestive Health, Fast Tract Diet, GERD, Heartburn, SIBO / What Really Causes Acid Reflux and GERD? What Really Causes Acid Reflux and GERD? Tweet. This is the first article of a four part series on acid reflux and GERD.. SIBO Symptoms. The main symptoms of SIBO are those of Irritable Bowel Syndrome (IBS). SIBO has been. Heartburn (Reflux or GERD) Nausea Leaky Gut.. Jun 29, 2018. So what causes heart burn then?. So you get a bacteria overgrowth in your small intestine (small intestine bacterial overgrowth or SIBO).. Small Intestine Bacterial Overgrowth (SIBO) is a condition that can often be overlooked as. The other symptoms seen in SIBO include heartburn, nausea, food.. Sep 15, 2014 · ACID REFLUX, what's that got to do with IBS? Since being diagnosed with IBS, I have discovered very useful information, one of which is that a big percentage of IBS sufferers also suffer with the chronic form of acid reflux. ...

TY - JOUR. T1 - Cyclosporine A-induced increase in glomerular cyclic GMP in rats and the involvement of the endothelin(B) receptor. AU - Tack, Ivan. AU - Marin-Castano, Encarna. AU - Bascands, Jean Loup. AU - Pecher, Christiane. AU - Ader, Jean Louis. AU - Girolami, Jean Pierre. PY - 1997. Y1 - 1997. N2 - 1. A transient two fold increase in the cyclic GMP content was observed in rat freshly isolated glomeruli 6 to 9 h after a single subcutaneous injection of 20 mg kg-1 cyclosporine A (CsA) in conscious animals. 2. In vitro stimulation with endothelin 3 (ET-3) of isolated glomeruli obtained from CsA-untreated rats resulted in a dose-dependent increase in cyclic GMP content. The increase observed with 10 nM ET-3 was similar to that observed in glomeruli isolated 9 h after in vivo CsA administration. 3. The rise in glomerular cyclic GMP content after in vivo CsA injection was prevented by in vivo treatment with L-NAME (10 mg kg-1) or by in vitro calcium deprivation of the incubation medium. 4. The ...

The doctors at the hospital would make a case history of the patient and the family and help you recommending medicines and therapies for McCune-Albright syndrome. Many physicians who are not endocrinologists believe in the vital treatment of MAS and timelyrecommendation of the patient to an endocrinologist who is experienced in its management.. The endocrinologist, consecutively, presents other referrals (to an orthopedic surgeon or neurosurgeon) as the initial check-up indicates. An incisive primary care physician (a pediatrician or an internist, as according to the age of the patient) who will synchronize the diverse aspects of the patient's care is also required. No procedures are on hand to put a stop to MAS; nevertheless, suitable care must be taken for fracture prevention in patients with severe polyostotic fibrous dysplasia (PFD).. The syndrome can be detected at birth if the baby is born with Café-au-lait spots. Or else, it would never be discovered until the child reaches puberty or ...

The prevalence of the small intestine bacterial overgrowth syndrome (SIBOS) in patients with gastroesophageal reflux disease (GERD), irritable bowel syndrome - umj.com.ua

BACKGROUND: Silver-Russell syndrome (SRS) is a clinically and genetically heterogeneous condition characterized by severe intrauterine and postnatal growth retardation. Loss of DNA methylation at the telomeric imprinting control region 1 (ICR1) on 11p15 is an important cause of SRS. METHODS: We studied the methylation pattern at the H19-IGF2 locus in 201 patients with suspected SRS. In an attempt to categorize the patients into different subgroups, we developed a simple clinical scoring system with respect to readily and unambiguously assessable clinical features. In a second step, the relationship between clinical score and epigenetic status was analyzed. Results and CONCLUSIONS: The scoring system emerged as a powerful tool for identifying those patients with both a definite SRS phenotype and carrying an epimutation at 11p15. 53% of the 201 patients initially enrolled fulfilled the criteria for SRS and about 40% of them exhibited an epimutation at the H19-IGF2 locus. Methylation defects were ...

A Trendelenburg operation is a surgical procedure conducted for the treatment of varicose veins. It is the juxtafemoral flush ligation of the great saphenous vein to the femoral vein. An oblique incision is made in the groin, over the femoral artery and extending 4 cm medially. The great saphenous vein is exposed and the common femoral and superficial femoral veins are identified before dividing. The vein is ligated close to the junction with of the femoral vein. If the ligation is distal from the saphenofemoral junction, it will leave out small tributaries which may later cause recurrence of varicosities. Additionally there is risk of a blind loop formation, which can be a potential space for the formation of thrombus. The rate of recurrence in this surgical procedure is high.[citation needed] BAILEY AND LOVE's Short practice of surgery 24th Edition, Page 963 SRB's MANUAL OF SURGERY 5th Edition, Page 234, Cumston, Charles Greene (May 1898). "VI. Varicose Veins and their Treatment by ...

Telecharger proteus design suite version 8.2 integrale vf fichier online vostfr francais. 8/10 (572 votes) - Télécharger Proteus Gratuitement. Proteus Design Suite est le logiciel de simulation de circuits électroniques dont vous avez besoin si vous . Proteus Design Suite by Labcenter Electronics, leading EDA software including schematic capture, advanced simulation, PCB autorouting, MCAD integration . Highlights of the new features and functionality added to recent versions of Proteus Design Suite. Find out about Design Rule Rooms, IoT Builder for Raspberry . Proteus - Proteus is a great electrical suite for circuit simulation purposes. You can simulate a single processor or multiple ones at the same time. The application . The Proteus 8.2 release expanded on Proteus V8.1 with a strong focus on library parts in both the schematic and the layout modules. Our other main . Ventricular tachycardia (VT)/ fibrillation (VF) is the most common cause of SD, . optimized (8.2AE1.2 mm) and standard 4 ...

Mary Ellen Sanders PhD, Executive Science Officer, International Scientific Association for Probiotics and Prebiotics. Bruno Pot PhD, Research Group of Industrial Microbiology and Food Biotechnology, Faculty of Sciences and Bioengineering Sciences, Vrije Universiteit Brussel, Pleinlaan 2, B-1050 Brussels, Belgium. See here for ISAPP letter to the Clinical and Translational Gastroenterology editor regarding this paper.. See related post Probiotics and D-Lactic Acid Acidosis in Children. Rao and colleagues incriminated probiotics in the induction of D-lactic acidosis in their paper titled "Brain fogginess, gas and bloating: a link between small intestinal bacterial overgrowth (SIBO), probiotics and metabolic acidosis" (Rao et al. 2018). Eamonn Quigley MD, Bruno Pot, microbiologist and I on behalf of ISAPP authored a letter to the editor of Clinical and Translational Gastroenterology (currently In Press), summarizing many medical and other concerns with the study design, execution and ...

Angelman syndrome (AS) is characterized by mental retardation, absence of speech, seizures and motor dysfunction. AS is caused by maternal deletions for chromosome 15q11-q13, paternal uniparental disomy (UPD), imprinting defects or loss-of-function mutations in the UBE3A locus which encodes E6-AP ubiquitin-protein ligase. The UBE3A gene is imprinted with paternal silencing in human brain and similar silencing of the Ube3a locus in Purkinje cells and hippocampal neurons in the mouse. We have sequenced the major coding exons for UBE3A in 56 index patients with a clinical diagnosis of AS and a normal DNA methylation pattern. The analysis identified disease-causing mutations in 17 of 56 patients (30%) including 13 truncating mutations, two missense mutations, one single amino acid deletion and one stop codon mutation predicting an elongated protein. Mutations were identified in six of eight families (75%) with more than one affected case, and in 11 of 47 isolated cases (23%); no mutation was found ...

Hemihyperplasia, also known as hemihypertrophy, is asymmetry in size between the right and left of the body, more than can be attributed to normal variation. Terminology Hemihyperplasia is more scientifically correct than hemihypertrophy as the...

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Bacterial overgrowth syndrome (BOS) is a term that describes clinical manifestations that occur when the normally low number of bacteria that inhabit the stomach, duodenum, jejunum, and proximal ileum significantly increases or becomes overtaken by other pathogens. The upper intestinal tract was once thought to be a sterile environment; howe...

NewEnglandBob. About 2 years ago I came down with something similar. It started as an ear infection, 2 days later the whole right side of my face had swollen so much that I looked like the elephant man. By day 3 I had puss just coming from the side of my cheek, but no sores. It was some of the worse pain I have ever had and it put me in the hospital for over a week. Anyway docs didn't have a clue what it was, that's even after sending specimens off to labs. They said I was very close to death and none of the antibiotics appeared to be doing much good. around day 5 I started getting better, the doctors said that it appeared as if my own immune system did most of the work not the antibiotics. Even though they couldn't get a conclusive results from the labs, they believed it was an ear infection the moved into the sub-dermal tissue and behaved kinda like a staff infection. They put me on a Z pack (zithromax?) first for the ear infection and it did absolutely nothing. I guess my point is, I think ...