Unilateral hypoplasia is a condition that is characterized by having two breasts of varying size and shape. Congenital asymmetry is a type of condition where the asymmetry has been developing since birth. Differently sized breasts can be problematic for women who may struggle to find appropriately fitting clothes or may have issues with their self-image. Treatment for unilateral hypoplasia varies from person to person but typically involves breast augmentation. The correction of a smaller breast requires the use of a tissue expander before any prosthesis can be surgically implanted.. Before the procedure, saline will slowly be added to the expander that has been inserted under the skin. The skin will gradually stretch to accommodate the expander. Consult with an experienced plastic surgeon like Dr. Richard Bartlett if you have questions about unilateral hypoplasia.. Contact us at our office in Boston to schedule a meeting with one of our qualified surgeons. ...
Physiologically-based pharmacokinetic (PBPK) modelling is traditionally employed to predict drug concentration-time profiles in plasma and tissues using information from physiology / biology, in vitro experiments and in silico predictions. Model-based analysis of population pharmacokinetic (PK) data is rarely performed in such a mechanistic framework, as empirical compartmental models are mainly utilised for this purpose. However, the combination of traditional PBPK methodologies with parameter estimation techniques and non-linear mixed effects modelling is an approach with progressively increasing impact due to the significant advantages it offers. Therefore, the general aim of this thesis is to illustrate, explore and thus further facilitate the application of physiologically-based pharmacokinetic models in the context of population data analysis.In order to pursue this aim, this work firstly particularly focuses on the population pharmacokinetics of simvastatin (SV) and its active metabolite, ...
A 15-year-old adolescent was admitted to the emergency department after a car accident because of severe traumatic brain injury. Upon arrival, he was sedated and intubated because of a Glasgow Coma Scale score below 8. He had isocoria with reactive pupils. An occipital puncture wound (diameter 2 cm) was profusely bleeding. His blood pressure was 85/45 mm Hg. Laboratory values identified a haemoglobin level of 4.6 mmol/l. A CT scan of the brain demonstrated a comminuted-depressed fracture of the parietal bone in the midline with a rupture of the superior sagittal sinus (SSS) and secondary thrombosis (figure 1). After prompt resuscitation including packed blood cells, a large biparietal decompressive craniectomy was performed centred at the skull fracture anticipating on intracranial hypertension due to venous oedema or infarction. The sinus haemorrhage was initially packed with haemostatic material and manually compressed with cottonoids and spatula until the roof of the sinus was reconstructed ...
Commencing at the foramen cecum, through which it receives emissary veins from the nasal cavity, it runs from anterior to posterior, grooving the inner surface of the frontal, the adjacent margins of the two parietal lobes, and the superior division of the cruciate eminence of the occipital lobe. Near the internal occipital protuberance, it drains into the confluence of sinuses and deviates to either side (usually the right). At this point it is continued as the corresponding transverse sinus. The superior sagittal sinus is usually divided into three parts: anterior (foramen cecum to bregma), middle (bregma to lambda), posterior (lambda to confluence).[1] It is triangular in section, narrow in front, and gradually increases in size as it passes backward. Its inner surface presents the openings of the superior cerebral veins, which run, for the most part, obliquely forward, and open chiefly at the back part of the sinus, their orifices being concealed by fibrous folds; numerous fibrous bands ...
Migraine is a debilitating neurological disorder involving abnormal trigeminovascular activation and sensitization. However, the underlying cellular and molecular mechanisms remain unclear. A rat model of conscious migraine was established through the electrical stimulation (ES) of the dural mater surrounding the superior sagittal sinus. Using patch clamp recording, immunofluorescent labelling, enzyme-linked immunosorbent assays and western blot analysis, we studied the effects of ES on sensory neuronal excitability and elucidated the underlying mechanisms mediated by voltage-gated ion channels. The calcitonin gene-related peptide (CGRP) level in the jugular vein blood and the number of CGRP-positive neurons in the trigeminal ganglia (TGs) were significantly increased in rats with ES-induced migraine. The application of ES increased actional potential firing in both small-sized IB4-negative (IB4−) and IB4+ TG neurons. No significant changes in voltage-gated Na+ currents were observed in the ES-treated
TY - JOUR. T1 - Transfrontal-Sinus-Subcranial Approach to Olfactory Groove Meningiomas: Surgical Results and Clinical and Functional Outcome in a Consecutive Series of 21 Patients. AU - Barzaghi, LR. AU - Spina, A. AU - Gagliardi, F. AU - Boari, N. AU - Mortini, P. PY - 2017. Y1 - 2017. N2 - Background The transfrontal-sinus-subcranial approach (TFSSA) allows for direct exposure and removal of olfactory groove meningiomas (OGMs), without any brain retraction. Compared with other skull base approaches (e.g., fronto-orbitobasal, transbasal, subcranial, fronto-orbitozygomatic, and one-and-half approach), it could offer the same advantages but is less invasive. Objective We report the results in a series of 21 consecutive patients with OGMs and operated on through TFSSA, to propose a viable alternative approach. Methods Mean maximum tumor diameter was 45.9 ± 3.4 mm (range, 25-70 mm). The aim of surgery was Simpson grade I removal. Surgical, clinical, and functional outcomes were reported. Mean ...
Skull Base Institute, New Fully Endoscopic Treatment for Olfactory Groove Meningiomas: Despite Being Told That it was Virtually Impossible Texas Man Undergoes Minimally Invasive Brain Surgery and Preserves his Sense of Smell
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Despite advances in neuroimaging techniques, these tumors are often very large by the time of diagnosis, because of a lack of familiarity with the clinical signs and symptoms.
We extend a physiologically-based lattice model for the transport and metabolism of drugs in the liver lobule (liver functional unit) to consider structural and spatial variability. We compare predicted drug concentration levels observed exiting the lobule with their detailed distribution inside the lobule, and indicate the role that structural variation has on these results. Liver zonation and its role on drug metabolism represent another aspect of structural inhomogeneity that we consider here. Since various liver diseases can be thought to produce such structural variations, our analysis gives insight into the role of disease on liver function and performance. These conclusions are based on the dominant role of convection in well-vascularized tissue with a given structure.
Tumor necrosis factor-α (TNF-α) is a soluble cytokine and target of specific monoclonal antibodies (mAbs) and other biological agents used for the treatment of inflammatory diseases. These biologics exert their pharmacological effects through binding and neutralizing TNF-α, and thus prevent TNF-α from interacting with its cell surface receptors. The magnitude of pharmacological effects is governed not only by the pharmacokinetics of mAbs, but also the kinetic fate of TNF-α. We have examined the pharmacokinetics of rhTNF-α in rats at low doses and quantitatively characterized its pharmacokinetic features with a minimal physiologically-based pharmacokinetic (mPBPK) model. Our experimental and literature-digitalized PK data of rhTNF-α in rats across a wide range of doses were applied for global model fitting. The rhTNF-α exhibits permeability rate-limited tissue distribution and its elimination is comprised of a saturable clearance pathway mediated by TNFR binding and disposition and renal ...
Absorption The absolute oral bioavailability of FARYDAK is approximately 21%. Peak concentrations of panobinostat are observed within 2 hours (Tmax) of oral administration in patients with advanced cancer. FARYDAK exhibits an approximate dose proportional increase in both Cmax and AUC over the dosing range.. Plasma panobinostat Cmax and AUC0-48 were approximately 44% and 16% lower compared to fasting conditions, respectively, following ingestion of an oral FARYDAK dose 30 minutes after a high-fat meal by 36 patients with advanced cancer. The median Tmax was also delayed by 2.5 hours in these patients.. The aqueous solubility of panobinostat is pH dependent, with higher pH resulting in lower solubility [see Description (11)]. Coadministration of FARYDAK with drugs that elevate the gastric pH was not evaluated in vitro or in a clinical trial; however, altered panobinostat absorption was not observed in simulations using physiologically-based pharmacokinetic (PBPK) models.. Distribution ...
The soluble cytokine TNF-α is an important target for many therapeutic proteins used in the treatment of rheumatoid arthritis (RA). Biologics targeting TNF-α exert their pharmacological effects through binding and neutralizing this cytokine and preventing it from binding to its cell surface receptors. The magnitude of their pharmacological effects directly corresponds to the extent and duration of free TNF-α suppression. However, endogenous TNF-α is of low abundance and therefore it is quite challenging to assess the free TNF-α suppression experimentally. Here we have applied an experimental approach to bypass this difficulty by giving the studied animals rhTNF-α through SC infusion. This boosted TNF-α enabled quantification of TNF-α in plasma. Free rhTNF-α concentrations were measured after separation from the infliximab-rhTNF-α complex using Dynabeads Protein A. The interrelationship of infliximab and TNF-α was assessed with minimal physiologically-based pharmacokinetic (mPBPK) ...
The protein therapeutic and CD95L inhibitor asunercept is currently under clinical investigation for the treatment of glioblastoma and myelodysplastic syndrome. The purpose of this study was to predict the asunercept pharmacokinetics in children and to give dose recommendations for its first use in pediatric glioblastoma patients. A physiologically-based pharmacokinetic (PBPK) model of asunercept in healthy and diseased adults was successfully developed using the available clinical Phase I and Phase II study data. This model was then extrapolated to different pediatric populations, to predict the asunercept exposure in children and to find equivalent starting doses. Simulation of the asunercept serum concentration-time curves in children between 1–18 years of age shows that a dosing regimen based on body weight results in a similar asunercept steady-state exposure in all patients (pediatric or adult) above 12 years of age. For children between 1–12 years, higher doses per kg body weight are
BACKGROUND:. Cerebral dysfunction frequently complicates septic shock. A marker of cerebral dysfunction could be of significant value in managing sedated septic patients. Plasma S100 (S100B) proteins increase in sepsis. S100B is present not only in the brain but also in other tissues. The source of this protein has not been investigated in sepsis. Our aim in this study was to determine whether the brain is an important source of S100B in an experimental sepsis model.. METHODS:. Twenty-seven pigs were anesthetized and randomized to either infusion of endotoxin at the rate of 1 µg · kg-1 · h-1 (n = 19) or saline (n = 8). Catheters were inserted into a cervical artery and the superior sagittal sinus. Blood samples were collected from both sites and physiologic data were registered before the start of the endotoxin infusion and hourly during the experiment. After 6 h, the animals were killed and brain tissue samples were taken from the left hemisphere. S100B in plasma was measured by ...
Todays powerful and actively evolving computational tools enable sponsors and regulators to understand potential drug characteristics and subject responses
The slice thickness that can be reconstructed depends on the volume of interest and the voxel size. The standard slice thickness is about 0.5 mm and there are additional reconstruction options that allow creation of lower slice thickness. The spatial resolution achieved with syngo DynaCT is about 0.22 mm. In addition, with syngo DynaCT Micro, a special protocol is available that provides high resolution 3D imaging, boosting the level of detail by using each detector pixel. With syngo DynaCT Micro an even higher spatial resolution of about 0.14 mm can be achieved.. ...
The trigeminovascular nociception induced by electrical stimulation of the dura mater surrounding the superior sagittal sinus in anesthetized animals has been widely used as a model for investigation of the pathophysiology of vascular headache such as migraine. However, little is known whether pain behaviors can be induced using this model in conscious animals. Thus, to establish a new model of trigeminovascular nociception in conscious animals and to examine the effects of morphine and rizatriptan benzoate on nociceptive behaviors in this new model, we electrically stimulated the dura mater surrounding the superior sagittal sinus. We found that grooming and head-flick activities were altered partially in a frequency-dependent way and that frequencies ranging from 10 to 20 Hz more easily provoked these behaviors. Moreover, we also demonstrated that these behaviors were reduced by morphine and rizatriptan benzoate. Thus, this new model will provide a useful and appropriate tool to directly assess changes
The emerging of nanotechnology has increasingly gained expansions and applications in various materials science research and development. However, the exposure to nanoparticles and engineered nanomaterials can lead to adverse biological effects because the small sizes of nanoparticles can enter the human body and deposit in the organs or translocate from the intake area to the secondary organs and can cause inflammation. One of the most used nanoparticles is TiO2, which is commonly found in skin care and household products. It is still unclear how TiO2 nanoparticles are remained in human bodies after exposing. In the present study, we develop a physiologically-based pharmacokinetic (PBPK) model to predict the bio-distribution of TiO2 concentrations in rat tissues. The model is validated with an existing in-vivo study in rats. We also extend our PBPK model to predict cell death caused by TiO2 nanoparticles in the rat liver using a dose-response model. The dose-response model accounts for the interplay
Turan Ö, Anuk-İnce D, Olcay L, Sezer T, Gülleroğlu K, Yılmaz-Çelik Z, Ecevit A. Neonatal cerebral sinovenous thrombosis: Two cases, two different gene polymorphisms and risk factors. Turk J Pediatr 2017; 59: 71-75. Cerebral sinovenous thrombosis (CSVT) is a rare disease in the neonatal period and also the greatest risk of neonatal mortality and morbidity. In this report, we presented two cases with CSVT and different risk factors. One of these cases had methylenetetrahydrofolate reductase (MTHFR) C677T homozygous polymorphism and the other case had both MTHFR A1298C homozygous polymorphism, plasminogen activator inhibitor-1 (PAI-1) 4G/ 5G polymorphism and elevated lipoprotein a ...
Indication: Patient with a large left basal ganglia hemorrhage extension to the ventricles and right sided weakness. CTA no convincing AVM or DAVF. Patient was transferred from ICU intubated after placement of EVD for diagnostic angiography with view to intervention.. Technique & Findings:. A left parietal DAVF at the left lateral wall of the superior sagittal sinus is identified receives supply predominantly from middle meningeal branches of the left , right with a compact nidus of fistulas, and rapid arteriovenous shunting with drainage to the dilated cortical veins including vein of trolard & then to the superior sagittal sinus. No other significant external carotid supply. No supply from the internal carotids or vertebral arteries bilaterally. No aneurysms or evidence of arteriovenous malformations. Conventional aortic arch. The lesion was distal to the site of bleeding but given the high grade Davf and risk of further bleeding for onyx embolization. A 6Fr guiding catheter was placed in the ...
Intracranial hemorrhage is a feared and limiting complication of thrombolytic therapy. Three patients in our thrombolysis group had pretreatment hemorrhagic infarcts. No worsening of these hemorrhages or progressive neurological deficits were identified in these patients. Two patients in our thrombolysis group developed hemorrhagic complications (unrelated to the venous thrombosis). We reviewed 96 cases of SSST (including our series) treated with local thrombolysis (urokinase, n=72; tissue plasminogen activator, n=23; streptokinase, n=1), as summarized in Table 3. Eighty-eight of these patients (92%) had a good recovery, 1 patient died, and 5 patients had worsening of intracranial hemorrhage without a fatal outcome (Table 3). Seven patients developed new hemorrhages (retroperitoneal bleed, n=3; intracerebral hemorrhage, n=2; subdural hemorrhage, n=1; hematuria, n=1) (Table 3). Horowitz et al7 described 13 patients, 4 of whom had pretreatment brain hemorrhages (Table 3). No worsening was seen ...
Class II:. PRODUCT. DIGITAL ANGIOGRAPHY SYSTEM: This system is intended to be used for radiologic visualization of the heart, blood vessels or lymphatic system during or after injection of a contrast medium. It is to be used in the diagnosis of the circulatory vascular system while being combined with a positioning device and other devices.. Recall Number: Z-0959-2019. REASON. Normal operation of the device is to power up the device in the morning, register the first patient, and then perform a fluoroscopy. If, however, the user powers up the device in the morning and makes an error by starting a fluoroscopy while the first patient is still being registered, the device application will abnormally terminate and require service intervention before it can be used again. This event will not occur after the first patient procedure.. RECALLING FIRM/MANUFACTURER. Shimadzu Medical Systems Usa Com on 1/14/2019. Voluntary: Firm Initiated recall is ongoing.. VOLUME OF PRODUCT IN ...
The Neurosurgical Atlas depends almost entirely on your donations. We are unable to continue the Atlas without a significant donation from you.. Please commit at least a yearly $250 donation to the Atlas.. Without this commitment, the Atlas will soon require a paid subscription and will become inaccessible to many surgeons around the world whose patients care depend on it. Please donate now!. ...
Tumors that arise within the ventricles present a unique surgical challenge. Because of their deep location, relatively large size, and their association with hydrocephalus, surgical planning requires a careful assessment of the optimal method to access the lesion and to provide adequate exposure for tumor resection. The transcallosal approach to the lateral ventricles often is the best procedure by which to achieve these goals.. Partial sectioning of the corpus callosum does not cause significant neurological deficits; however, if the surgery induces additional brain injury, the neurological deficits can be more severe in the presence of a callosotomy. Knowledge of the techniques of transcallosal surgery and careful preoperative planning can reduce the risk of permanent neurological impairment; these range from protection of the cortical veins that drain into the superior sagittal sinus to brain relaxation and ventricular drainage, as well as proper identification of anatomical landmarks within ...
PRINCETON, NJ - Oct. 19, 2016 - Certara announces that the Office of Generic Drugs (OGD), US Food and Drug Administration (FDA) has awarded it a multi-year research grant to create and validate a physiologically-based pharmacokinetic (PBPK) modeling and simulation framework that complements existing models within the
Introduction: High blood velocity can cause rapid erythrocyte transit through capillaries, reducing efficiency of oxygen delivery to tissue (capillary arteriovenous shunting). Arterial spin labeling (ASL) is an MRI technique that utilizes magnetic labeling of arterial blood water for CBF quantitation. Labeled water that traverses capillaries without exchanging with tissue leads to hyperintense venous signal indicative of arteriovenous shunting. We hypothesized that venous hyperintensity is present in sickle cell anemia (SCA) adults, correlates with flow velocity, and corresponds with clinical impairment and oxygen extraction fraction (OEF).. Methods: ASL for shunting determination, TRUST for OEF measurement, phase contrast angiography for velocity assessment, and FLAIR / MRA for infarct / vasculopathy evaluation were performed at 3T in adults with SCA (n=36) and age- and race-matched controls (n=11). Three reviewers assessed for hyperintensity in the superior sagittal sinus on ASL images (Fig) ...
Olfactory groove meningioma: narrow working angle, blinded in upper portion of tumor --, frontal lobe retraction, difficult access to ethmoid arteries, difficult to repair basal skull defects ...
May 12, 2008 - A team from the Foothills Medical Centre completed the first surgical removal of a brain lesion with the help of an image-guided neurosurgical robot, neuroArm. The patient, 21-year old Paige Nickason, had an olfactory groove meningioma, which was affecting her sense of smell, removed with no complications. Paige suffers from a medical condition, neurofibromatosis, that causes tumours to develop along her exiting cranial nerves. The surgery was the third neurosurgical procedure that she had undergone to date. I had to have the tumour removed anyway, so I was happy to help by being a part of this historical surgery, Nickason said. Dr. Garnette Sutherland, the neurosurgeon performing the operation, manipulated the human-like robotic arms from an adjacent control room. Dr. Sutherland confirmed that the surgery was a success, in part due to the increased safety of the machine. Robotic technology is intrinsically more precise and accurate compared to a surgeons hand, Sutherland ...
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Anencephaly is the health condition in which there is the absence of a major portion of the skull, brain, and scalp which occurs during embryonic development. This cephalic disorder is caused by the defect of a neural tube occuring when the head (rostral) end of the neural tube does not close, in most cases between the 23rd and 26th day after conceiving. This is the forum for discussing anything related to this health condition
mishuq: according to sss you leave a table when you reach 25 % profit or more lets say a table is sharp but somehow you dont want to close it yet (you
Prévu pour le 18 novembre, Fabriclive 90 mixé par Kahn & Neek fait notamment appel à des titres exclusifs de Gantz, Hi5Ghost ou O.B.F..
TY - JOUR. T1 - Parasagittal and parafalcine meningiomas. T2 - integral strategy for optimizing safety and retrospective review of a single surgeon series. AU - Eichberg, Daniel G.. AU - Casabella, Amanda M.. AU - Menaker, Simon A.. AU - Shah, Ashish H.. AU - Komotar, Ricardo J. PY - 2019/1/1. Y1 - 2019/1/1. N2 - Background: Parafalcine and parasagittal meningiomas present unique challenges for resection. Although maximal safe resection is the primary goal of surgical management for these lesions, venous infarction and eloquent cortical structure damage occur in up to 14% of cases. Therefore, optimal preoperative planning and intraoperative technique is critical. Methods: We retrospectively reviewed a single surgeons case series with resection of 58 parafalcine and parasagittal meningiomas. Operative strategy included not crossing the superior sagittal sinus (SSS) during craniotomy, not resecting the falx, use of motor evoked potentials (MEPs) to avoid damage to eloquent brain, and selective ...
superior cerebral veins Numerous (8 to 10) veins that drain the dorsal convexity of the cortical hemisphere and empty into the superior sagittal sinus, curving rostrally in passing through the subdural space so as to enter the sinus at an acute forward angle. ...
In cases of advanced-stage temporal bone carcinoma, both extensive resections and high-dose irradiation are recommended (6). Although the prognosis of a patient with a T4/stage 4 lesion is grim, survival is better when clear surgical margins can be achieved (5). When an individual situation is assessed, the justified use of radical surgery must be weighted against potential morbidities that may result from facial nerve or ICA resection or the need to sacrifice the dominant sigmoid sinus, as in the present case.. If a dural sinus is completely occluded because of tumor invasion, adequate venous collaterals have developed and the affected sinus can be excised without ensuing venous complications (7). If the affected sinus is still patent, however, the risk of sinus occlusion is high, especially in the posterior two-thirds of the superior sagittal sinus and the dominant transverse or sigmoid sinus; this situation entails the risk of intracranial hypertension and venous infarction (3, 4, 7). ...
Drug-drug interactions resulting from the inhibition of an enzymatic process can have serious implications for clinical drug therapy. Quantification of the drugs internal exposure increase upon administration with an inhibitor requires understanding to avoid the drug reaching toxic thresholds. In this study, we aim to predict the effect of the CYP3A4 inhibitors, itraconazole (ITZ) and its primary metabolite, hydroxyitraconazole (OH-ITZ) on the pharmacokinetics of the anesthetic, midazolam (MDZ) and its metabolites, 1 hydroxymidazolam (1OH-MDZ) and 1 hydroxymidazolam glucuronide (1OH-MDZ-Glu) using mechanistic whole body physiologically-based pharmacokinetic simulation models. The model is build on MDZ, 1OH-MDZ and 1OH-MDZ-Glu plasma concentration time data experimentally determined in 19 CYP3A5 genotyped adult male individuals, who received MDZ intravenously in a basal state. The model is then used to predict MDZ, 1OH-MDZ and 1OH-MDZ-Glu concentrations in an CYP3A-inhibited state following ITZ
The details show the relationships of the meninges in the area of the superior sagittal sinus, on the lateral aspect of the cerebral hemisphere, and around the spinal cord. Cerebrospinal fluid is produced by the choroid plexi of lateral, third, and fourth ventricles. It circulates through the ventricular system (small arrows) and enters the subarachnoid space via the medial foramen of Magendie and the two lateral foramen of Luschka. In the living situation the arachnoid is attached to the inner surface of the dura. Chronic subdural hematomas, usually seen in the elderly, are frequently of unknown origin; may take days or weeks to become symptomatic; and cause a progressive change in mental status of the patient. This lesion appears long and thin, compared to an epidural hematoma, follows the surface of the brain, and may extend for considerable distances (see Fig. 2-48 on p. 48 and Fig. 2-51 on p. 51). Treatment is surgical evacuation (for larger or acute lesions) or close monitoring for ...
A case of sinus pericranii communicating with the right transverse sinus is reported. The radiographic findings on CT, angiography, and magnetic resonance imaging are presented.
The Brain & Spine Centre treats different types of Meningiomas such as sphenoid wing, parasagittal, spinal, olfactory groove, convexity, suprasellar India.
Results. Ultrasonographically 22 presented stenosis (73.3%), 8 cases (36%) were mild, 9 cases (40.9%) moderate, 3 cases (13.6%) severe and obstruction in 2 (9%). Angiographically 12 (40%) stenosis cases were corroborated. AngioCT showed stenosis in 20 arteries (66.6%). Six cases were mild (30%), 7 (35%) moderate, 5 (25%) severe and 2 had obstruction (10%). These were corroborated in 50% with digital angiography. The sensitivity for US was 81%, for angioCT 100%, the specificities were 73% and 76%, respectively, the positive predictive value was 64% for both methods, and the negative predictive values were 87% and 100%, respectively ...
Good Times Restaurants announced that its SSS for its Q2 ended March 31 increased 17.8%, representing a two year increase of 24.7%, and that SSS increased 19.2% for the month of March on top of last years ...
TY - JOUR. T1 - Supraorbital ethmoid cell. T2 - A consistent landmark for endoscopic identification of the anterior ethmoidal artery. AU - Jang, David W.. AU - Lachanas, Vasileios A.. AU - White, Lauren C.. AU - Kountakis, Stilianos E. PY - 2014/12/4. Y1 - 2014/12/4. N2 - Objective. To demonstrate that the supraorbital ethmoid cell (SOEC) is a consistent and reliable landmark in identification of the anterior ethmoidal artery (AEA).Study Design. Retrospective radiographic study.Setting. Tertiary care rhinology practice.Subjects and Methods. The computed tomography (CT) scans for 78 consecutive patients were evaluated for the presence of SOECs, degree of pneumatization, and location of the AEA in relation to fixed anatomic structures. Forty-one patients with normal SOECs were identified and compared with a group of 15 patients with pathological expansion of the SOEC secondary to inflammatory disease. The CT findings were correlated with endoscopic findings.Results. The incidence of SOECs was 53%. ...
MalaCards based summary : Sagittal Sinus Thrombosis, also known as thrombosis of superior longitudinal sinus, is related to hyperthyroidism and budd-chiari syndrome. An important gene associated with Sagittal Sinus Thrombosis is SERPINC1 (Serpin Family C Member 1), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. Affiliated tissues include brain, myeloid and b cells, and related phenotype is embryo ...
The dural venous sinuses are the meningeal ducts or conduits, into which the venous blood from the cerebral veins flows. Located in the dura mater of the meninges, just over the brain surface, their function is to drain the oxygen-depleted blood, which comes from the brain via de cerebral veins, and excess cerobrospinal fluid into the internal jugular vein. There are several dural sinuses in the meninges; they are: superior sagittal sinus, inferior sagittal sinus, straight sinus, occipital sinus, sphenoparietal sinus, cavernous sinuses, confluence of sinuses, superior petrosal sinus, inferior petrosal sinus, transverse sinus, and sigmoid sinus. ...
Headache & Sagittal Sinus Thrombosis & Suppression Temporal Symptom Checker: Possible causes include Traumatic Brain Injury. Check the full list of possible causes and conditions now! Talk to our Chatbot to narrow down your search.
Dizziness & Sagittal Sinus Thrombosis Symptom Checker: Possible causes include Traumatic Brain Injury & Dehydration & Brain Neoplasm. Check the full list of possible causes and conditions now! Talk to our Chatbot to narrow down your search.
Posterior internal frontal artery, Anterior parietal artery, Paracentral artery, Posterior parietal artery, Anterior internal frontal artery, Superior internal parietal artery, Medial internal frontal artery, Inferior internal parietal artery, Frontal polar artery, Artery of the angular gyrus, Pericallosal artery, Posterior temporal artery, Prefrontal arteries, Second segment of the middle cerebral artery, Second segment of the anterior cerebral artery, Anterior choroidal artery, Frontal orbital artery, Posterior communicating artery, Ophthalmic artery, Internal carotid artery, Callosomarginal artery, Superior sagittal sinus, Parietal vein, Superior anastomotic vein (vein of Trolard), Occipital veins, Inferior sagittal sinus, Internal cerebral vein, Superior thalamostriate veins, Vein of the septum pellucidum, Straight sinus, Great cerebral vein of Galen, Ascending frontal veins, Basal vein of Rosenthal, Inferior anastomotic vein (vein of Labbé), Veins of the fossa of Sylvius, Confluence of ...
OBJECTIVE: The causes of cerebral sinus and vein occlusion and the accompanying parenchymal changes remain largely unexplained. The clinical variability and low incidence of the disease complicate systematic clinical investigations. Animal studies are indispensable; however, existing animal models of sinus thrombosis do not allow for long-term follow-up studies and are not suitable for pharmacological recanalization because sinus thrombosis is induced by ligation and injection of thrombogenic substances and does not resemble sinus thrombosis in humans.. METHODS: We induced thrombosis of the superior sagittal sinus (SSS) by careful topical application of ferric chloride onto the SSS of rats, leading to highly reproducible occlusions. Magnetic resonance imaging was performed immediately after initiation of thrombosis and on postoperative Days 1, 2, and 7. Diffusion- and T2-weighted images allowed for calculation of the apparent diffusion coefficient and T2 relaxation time. Vascular status was ...
The dura mater has been cut away so that the left cerebral hemisphere is visible lying inside the arachnoid membrane. The tentorium appears in the lower right part of the view and the transverse sinus is opened along its posterior border. The superior sagittal sinus has been opened by removing a strip of dura from its superficial wall. The superior cerebral veins ascend on the surface of the frontal and parietal lobes to empty into this sinus at various points. A number of anastomoses are present between these veins, none being particularly large in this specimen. In general the superior cerebral veins are divided into anterior and posterior groups. In this case there appear to be several anterior vessels, a group of large veins intermediate in position (overlying the region of the central sulcus) and several posterior veins (not visible in this view ...
Although they are uncommon in children when compared to adults, both ischemic and hemorrhagic strokes occur. In US children, hemorrhagic strokes have an incidence of 2.9/100,000 per year for hemorrhagic events versus 2.8/100,000 per year for ischemic events.1-3 Ischemic strokes can be categorized as arterial ischemic strokes (AIS) and cerebral sinovenous thrombosis (CSVT). In the pediatric population, arterial ischemic stroke usually results from a thromboembolism. Occlusion of venous sinuses or cerebral veins can result in CSVT. The majority of ischemic and hemorrhagic strokes occur in the neonatal period, but both occur in older children and adolescents; so this chapter will focus on those from 29 days to adolescence.3 The signs of AIS vary with age and the area of the brain affected by ischemia; they include focal ...
Craniotomy: A right-sided craniotomy is typically used (unless the surgeon is left-handed). A rectangular bone flap whose medial edge is the craniums midline is cut. The inferior edge of the craniotomy should be cut as flush as possible with the orbital roof. A bifrontal craniotomy may be useful in some cases. In these cases the superior sagittal sinus and falx should be divided as far anteriorly as possible (28). If the frontal sinus is entered, its mucosa is pushed downward before the internal wall of the sinus is removed, and the sinus should be obliterated during closure. When needed, the orbital roof can be removed by incorporating it into the frontal flap as a single piece (17 ...
The inner surface of the vault is very smooth in comparison with the floor. It does feature a few bumps and grooves. For example, the frontal crest - a notch of bone just behind the frontal sinus. The frontal crest is an attachment point for a fold in the membranes covering the brain (falx cerebri).. Just above the occipital bone and close to the midline of the skull cap are the parietal foramina. Just as with all foramina, important blood vessels and nerves travel through them. They are not visible in the above image.. A vertical groove passes through the middle of the cranial vault - the sagittal groove or sulcus - that provides space for the superior sagittal sinus (part of the drainage mechanism for cerebrospinal fluid and blood). The raised edge of this groove is just visible to the left of the above image.. Below, the position of the various sinuses shows how adept the brain is at removing waste products and extra fluid from its extremely delicate tissues.. ...
Case: A 56 year old man presented with new onset headaches with visual symptoms. Physical examination was normal apart from asymmetrical papilledema and reduced visual acuity 6/9 bilaterally. CSF opening pressure was 26 cm H2O. CTV showed partially recanalised thrombosis in the superior sagittal sinus and the right sigmoid and transverse sinuses which appeared chronic. His headaches initially improved with propranolol but he continued to complain of visual symptoms; repeat CSF opening pressure was 31 cm H2O and repeat CTV was reported as, more occlusive. He was therefore anti-coagulated and treated with acetazolamide.. Six weeks after starting treatment, ophthalmological assessment found worsening visual fields despite reduction in disc swelling on OCT. CSF pressure remained elevated at 30 cm H2O. Repeat CTV and 4D CTA identified a type IIB occipital dural AV fistula around the thrombosed venous sinuses, causing occipital lobe congestion; the likely cause of the visual field defects.. The ...
In 1998, Corvol et al (8) reported the findings in a case of extensive thrombosis of the superior sagittal sinus and left lateral sinus. There was a large frontoparietal hyperintensity on FLAIR images and only a discrete hyperintensity on diffusion-weighted images, with a very slight decrease in ADC values (0.53 × 10−3 mm2/s compared with 0.61 × 10−3 mm2/s in the contralateral hemisphere). These findings were explained as being the result of prominent vasogenic edema associated with mild cytotoxic edema. The patient was treated with IV heparin, with a favorable outcome.. In 1999, Keller et al (9) reported the findings in a case of deep cerebral venous thrombosis with extensive hyperintensities in the basal ganglia on T2-weighted images and hypointensities on diffusion-weighted images, with increased ADC values (1.1-1.6 × 10−3 mm2/s). These findings were explained as being the result of vasogenic edema. The patient was treated with IV heparin and had a total clinical recovery; no ...
Unilateral hypoplasia of the breast and the pectoralis muscle with a missing anterior axillary fold as part of Polands syndrome are of major concern, especially for women. The latissimus dorsi is one of the most suitable flaps for breast and anterior thorax reconstructions but it may be hypoplastic …
the case.. 39 year old female presents to your Emergency Department with a four day history of a gradually worsening headache. Whilst she has a past history of migraines, this headache is much more severe and of different character to any migraine she has had previously. [Read more…]. ...
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In their 2011 paper, Cunnane and colleagues review the literature on brain glucose metabolism studies in Alzheimers Type Dementia. One of the key concepts in understanding brain glucose metabolism is the cerebral metabolic rate of glucose. This was calculated by comparing the glucose content of cerebral arterial and cerebral venous blood. When this difference is…
TY - JOUR. T1 - Susceptibility-weighted imaging effectively reveals small cavernomas. AU - Kataoka, Seiko. AU - Wakita, Hideaki. PY - 2013/12/5. Y1 - 2013/12/5. UR - http://www.scopus.com/inward/record.url?scp=84888816807&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=84888816807&partnerID=8YFLogxK. U2 - 10.2169/internalmedicine.52.1214. DO - 10.2169/internalmedicine.52.1214. M3 - Comment/debate. C2 - 24292767. AN - SCOPUS:84888816807. VL - 52. SP - 2687. EP - 2688. JO - Internal Medicine. JF - Internal Medicine. SN - 0918-2918. IS - 23. ER - ...
Registration for the SSS Corinthian Race will open on Feb. 6 in the AM. Please READ below carefully since priority will be given to current SSS members first. Sat and Sun race registration will be for current SSS members only. But, on Sat and Sunday, you may elect to become an SSS member and register for the race. Monday & forward will be registration for any single race entries (in other words non SSS members) or those who may have missed the Sat and Sunday opportunities.
A loccasion de sa première performance live en Europe lors de lédition 2015 du Berlin Atonal cet été, le japonais Ena nous dévoile un pan de sa musique riche en expérimentations