The nonsteroidal anti-inflammatory drug sulindac is known to inhibit chemical carcinogenesis in rodent models and cause regression of adenomas in patients with adenomatous polyposis coli. Sulindac is a prodrug that is metabolized to a pharmacologically active sulfide derivative that potently inhibits prostaglandin synthesis. Recent studies, however, have shown that a sulfone derivative of sulindac, which essentially lacks prostaglandin synthesis inhibitory activity, also inhibits chemical carcinogenesis, suggesting that reduction of prostaglandin levels is not necessary for the antineoplastic activity of this class of drugs. Both sulindac sulfide and the sulfone inhibit the growth of cultured tumor cells, although the cellular mechanism(s) responsible for the antineoplastic activity of sulindac derivatives is unknown. In this study, we investigated the effects of sulindac sulfide and sulfone on the proliferation, differentiation, and apoptosis of HT-29 human colon carcinoma cells. Sulindac ...

The nonsteroidal anti-inflammatory drug sulindac can reduce the incidence of gastrointestinal adenomas in the Min mouse model of familial adenomatous polyposis (10) . This effect is associated with an increase in apoptosis in the luminal portion of the crypt-villus of Min mice, a reduction in mucosal cyclooxygenase-2 protein levels, and a reduction in prostaglandin E2 levels in normal-appearing small bowel mucosa (10) . In patients with FAP, treatment with sulindac can induce the regression of polyps, although disease progression resumes when treatment is discontinued (8) . These effects have been attributed to the ability of the sulfide metabolite of sulindac to inhibit cyclooxygenase-2 (10) . APCΔ23 knockout mice are a murine model of FAP in which a truncating mutation of the APC gene results in gastrointestinal polyp formation (23) . In APCΔ23 mice in whom COX-2 has also been knocked-out, the rate of adenoma formation is greatly attenuated, further suggesting that COX-2 is important to the ...

Sulindac causes regression of and prevents recurrence of colonic adenomas in patients with familial adenomatous polyposis. Although cell cycle arrest and apoptosis have been proposed, the mechanism of action is poorly understood. In this study, we characterized the growth-inhibitory effects of active metabolites of sulindac in cultured colon adenocarcinoma cells by determining the contribution of apoptosis and cell cycle arrest and the requirement for cyclooxygenase (COX) inhibition and p53 involvement and compared the effects of sulindac metabolites with the chemotherapeutic drug, 5-fluorouracil (5-FU). Time course and dose-response experiments demonstrated that increased apoptosis paralleled the growth-inhibitory effects of the sulfide and sulfone. A relationship among a series of nonsteroidal anti-inflammatory drugs was observed between potency for growth inhibition and ability to induce apoptosis but not potency to inhibit COX. For example, the sulfone was at least 5000-fold less potent than ...

Abstract: Non-steroidal anti-inflammatory drugs such as sulindac are promising chemoprevention agents against colon cancer, but their weak potency and side effects limit their use for both chemoprevention and chemotherapy. Here, we evaluated the effect of a new sulindac derivative, phospho-sulindac or OXT-922, on the growth of human cancer cell lines and its mechanism of action. OXT-922 inhibited the growth of human cancer cell lines originating from colon, pancreas and breast ~11- to 30-fold more potently than sulindac. This effect was mediated by a strong cytokinetic effect. Compared with control, OXT-922 inhibited cell proliferation by up to 67%, induced apoptosis 4.1-fold over control and blocked the G1 to S cell cycle phase transition. OXT-922 suppressed the levels of cell cycle regulating proteins, including cyclins D1 and D3 and Cyclin-dependent kinases (CDK) 4 and 6. The levels of intracellular reactive oxygen species (ROS), especially those of mitochondrial ...

TY - JOUR. T1 - Does mutated K-RAS oncogene attenuate the effect of sulindac in colon cancer chemoprevention?. AU - Rice, Photini F.S.. AU - Ehrichs, Kevin G.. AU - Jones, Mykella S.. AU - Chen, Hwudarw. AU - Hsu, Chiu Hsieh. AU - Abril, Edward R.. AU - Nagle, Raymond B.. AU - Besselsen, David G.. AU - Barton, Jennifer K.. AU - Ignatenko, Natalia A.. N1 - Publisher Copyright: © 2017 American Association for Cancer Research. Copyright: Copyright 2019 Elsevier B.V., All rights reserved.. PY - 2018/1. Y1 - 2018/1. N2 - The NSAID sulindac has been successfully used alone or in combination with other agents to suppress colon tumorigenesis in patients with genetic predisposition and also showed its efficacy in prevention of sporadic colon adenomas. At the same time, some experimental and clinical reports suggest that a mutant K-RAS oncogene may negate sulindac antitumor efficacy. To directly assess sulindac activity at suppressing premalignant lesions carrying K-RAS mutation, we utilized a novel ...

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Synonyms for sulindac in Free Thesaurus. Antonyms for sulindac. 1 synonym for sulindac: Clinoril. What are synonyms for sulindac?

Sulindac - Get up-to-date information on Sulindac side effects, uses, dosage, overdose, pregnancy, alcohol and more. Learn more about Sulindac

In patients with ankylosing spondylitis, the anti-inflammatory and analgesic activity of sulindac was demonstrated by clinical measurements that included: assessments by both patient and investigator of overall response; decrease in disease activity as assessed by both patient and investigator; improvement in ARA Functional Class; improvement in patient and investigator evaluation of spinal pain, tenderness and/or spasm; reduction in the duration of morning stiffness; increase in the time to onset of fatigue; relief of night pain; increase in chest expansion; and increase in spinal mobility evaluated by fingers-to-floor distance, occiput to wall distance, the Schober Test, and the Wright Modification of the Schober Test. In a clinical study in which dosages were adjusted according to patient need, sulindac 200 to 400 mg daily was as effective as indomethacin 75 to 150 mg daily. In a second study, sulindac 300 to 400 mg daily was comparable in effectiveness to phenylbutazone 400 to 600 mg daily. ...

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Results Sulindac and sulfide were detectable in 57.7% of NAF samples with sulfone detectable in 11.6%. There were no statistically significant differences between sulindac or sulfide levels in NAF by dose. There was a significant positive correlation between NAF sulindac and NAF sulfide levels. NAF 13,14-dihydro-15-keto prostaglandin A2 (PGEM), a stable derivative of prostaglandins, exhibited a non significant trend towards decreased levels (p =0.1). Serum levels of sulindac, but not NAF sulindac, was correlated with a decrease in NAF PGEM levels (p=0.03). The NSAID inducible protein, growth differentiation factor GDF-15, showed a borderline significant trend towards higher levels in NAF in the 300 mg daily group (p = 0.07). Serum CRP levels were decreased with sulindac exposure with the greatest decrease observed among those women with elevated CRP levels at baseline. ...

Background: - Some types of inflammation may increase the risk of cancers in the intestinal track. Because of this possibility, anti-inflammatory

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19. ...

In this prospective, randomized clinical trial, 6-month interventions with sulindac, atorvastatin, and ORAFTI®Synergy1 did not yield significant reductions in rectal ACF number, as compared with control (maltodextrin), among subjects at increased risk for sporadic CRC. To our knowledge, this study represents the largest ACF-based CRC chemoprevention trial reported to date and the first such trial to be conducted in a stand-alone fashion rather than ancillary to or embedded within a larger parent study. Furthermore, secondary analyses of tissue-based biomarkers (assessed from normal appearing rectal mucosa) in our study revealed that none of the interventions had a statistically significant effect on cellular proliferation whereas all of interventions (including the maltodextrin control) were associated with increased apoptosis. Yet, because the observed proapoptotic effects did not differ appreciably between the active and control interventions, the relevance of these latter data to defining ...

Dr. Namey responded: Non-steroidal drug.. Very effective for pain, albeit slightly slower in acting effectively. That is because |a href=/topics/sulindac track_data={

This segment of the eMedTV archives lists common sulindac side effects that may occur, such as headache, dizziness, and diarrhea. Other less common side effects and serious problems that require medical attention are also included.

Atkinson, M.; Germain, G.; Lee, P., 1988: The efficacy and safety of sulindac 400 mg vs 600 mg daily in rheumatoid arthritis a canadian multicenter study

Learn about Clinoril (Sulindac) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and related medications.

Although EGFR has been validated as the first molecular target in HNSCC, absolute improvement in a clinically reliable endpoint following exposure to an EGFR inhibitor is limited to 10% to 20% of patients, implicating intrinsic resistance despite EGFR overexpression in the vast majority (6, 7, 9). Predictive biomarkers for anti-EGFR therapy in HNSCC represent a major unmet need. The current trial took advantage of a window design to investigate mechanistic signaling hypotheses about response and resistance to short-term erlotinib, with or without sulindac, in HNSCC. The study met its primary endpoint. First, we observed differential downmodulation of the Ki67 proliferation index across treatment groups, attributable to erlotinib or erlotinib-sulindac as compared with placebo. Second, we confirmed that sulindac potentiates the antiproliferative effect of erlotinib in a formal test of trend, indicating that the forward feedback loop between COX2 and EGFR is a relevant clinical target. Finally, we ...

Tell your doctor or health care professional if your pain does not get better. Talk to your doctor before taking another medicine for pain. Do not treat yourself.. This medicine does not prevent heart attack or stroke. In fact, this medicine may increase the chance of a heart attack or stroke. The chance may increase with longer use of this medicine and in people who have heart disease. If you take aspirin to prevent heart attack or stroke, talk with your doctor or health care professional.. Do not take medicines such as ibuprofen and naproxen with this medicine. Side effects such as stomach upset, nausea, or ulcers may be more likely to occur. Many medicines available without a prescription should not be taken with this medicine.. This medicine can cause ulcers and bleeding in the stomach and intestines at any time during treatment. Do not smoke cigarettes or drink alcohol. These increase irritation to your stomach and can make it more susceptible to damage from this medicine. Ulcers and ...

SJS usually begins with fever, sore throat, and fatigue, which is misdiagnosed and usually treated with antibiotics. Ulcers and other lesions begin to appear in the mucous membranes, almost always in the mouth and lips but also in the genital and anal regions. Those in the mouth are usually extremely painful and reduce the patients ability to eat or drink. Conjunctivitis of the eyes occurs in about 30% of children who develop SJS. A rash of round lesions about an inch across arises on the face, trunk, arms and legs, and soles of the feet, but usually not the scalp ...

As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.

Then I am away for four days-come back on Sunday. See my rhuemy on Monday. Need to ask her about going back on Sulindac if I can find the courage to ask her ...

Author(s): Meyskens, Frank L, Jr; McLaren, Christine E; Pelot, Daniel; Fujikawa-Brooks, Sharon; Carpenter, Philip M; Hawk, Ernest; Kelloff, Gary; Lawson, Michael J; Kidao, Jayashri; McCracken, John; Albers, C Gregory; Ahnen, Dennis J; Turgeon, D Kim; Goldschmid, Steven; Lance, Peter; Hagedorn, Curt H; Gillen, Daniel L; Gerner, Eugene W | Abstract: Preclinical studies of chemoprevention drugs given in combination at low doses show remarkable efficacy in preventing adenomas with little additional toxicities, suggesting a strategy to improve risk to benefit ratios for preventing recurrent adenomas. Three hundred seventy-five patients with history of resected (> or =3 mm) adenomas were randomly assigned to receive oral difluoromethylornithine (DFMO) 500 mg and sulindac 150 mg once daily or matched placebos for 36 months, stratified by use of low-dose aspirin (81 mg) at baseline and clinical site. Follow-up colonoscopy was done 3 years after randomization or off-study. Colorectal adenoma recurrence was

From a rheumatology perspective: NSAIDs have become the treatment of choice for the management of many rheumatic conditions, and elderly persons are among the most frequent users of these medications. Although the mechanisms of anti-inflammatory action of NSAIDs are multiple, prostaglandin blockade is responsible for many of their known side effects. Serious gastrointestinal complications, such as bleeding, perforation, or gastric ulcers requiring hospitalization, are increasingly being recognized. Their frequency, morbidity, mortality, and associated risk factors are the subject of numerous ongoing investigations. NSAID-associated renal dysfunction is also a concern. This report is 1 of a recently published series that documents the renal sparing effects of sulindac compared with other NSAIDS. It shows that short-term administration of sulindac does not affect renal prostaglandin synthesis, glomerular filtration rate, and renal blood flow. Whether these properties would persist with long-term ...

Part A: Patients, in cohorts of 5-10, receive one of the following five treatments in addition to the control diet: nothing (arm I), oral sulindac twice a day (arm II), oral rutin at 1 of 3 doses twice a day (arms III, IV, and V), oral quercetin at 1 of 3 doses twice a day (arms V, VI, and VII), or at 1 of 3 doses oral curcumin twice a day (arms VIII, IX, and X). Patients are first randomized to the highest doses of rutin, quercetin, and curcumin and then lower doses may be given in order to determine the minimally effective dose. Treatment is continued for 6-10 weeks ...

8. Frank L. Meyskens, Jr.1, Christine E. McLaren1, Daniel Pelot1, Sharon Fujikawa-Brooks1, Philip M. Carpenter1, Ernest Hawk9, Gary Kelloff9, Michael J. Lawson7, Jayashri Kidao3, John McCracken4, C. Gregory Albers1, Dennis J. Ahnen6, D. Kim Turgeon5, Steven Goldschmid2, Peter Lance2, Curt H. Hagedorn8, Daniel L. Gillen1 and Eugene W. Gerner2 Difluoromethylornithine Plus Sulindac for the Prevention of Sporadic Colorectal Adenomas: A Randomized Placebo-Controlled, Double-Blind Trial Cancer Prevention Research 1, 32-38, June 1, ...

Please provide below the URL and description of an activity you would like to add to OpenCME. You are welcome to add activities as often as you like. To prevent spam or other abuse, activities are reviewed by our editorial team before appearing on OpenCME. ...

Increased bleeding time, anaemia, dizziness, headache, nervousness, visual disturbances, ringing in the ears, nausea, vomiting, ulcers, abdominal distress,swelling, itching, rash, and elevated liver enzymes.. ...

A new preventive treatment by giving sulindac and erlotinib drugs in combination can prevent familial adenomatous polyposis (FAP) of the colon and decrease the risk of cancer.

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For more information about Sanford-Burnham research, visit www.beaker.sanfordburnham.org.. Original paper: Zhou H, Liu W, Su Y, Wei Z, Liu J, Kolluri SK, Wu H, Cao Y, Chen J, Wu Y, Yan T, Cao X, Gao W, Molotkov A, Li W-G, Lin B, Zhang H-P, Yu J, Luo S-P, Zeng J-z, Duester G, Huang P-Q, Zhang X-k. NSAID Sulindac and Its Analog Bind RXRá and Inhibit RXRá-dependent AKT Signaling. Cancer Cell. Published online June 15, 2010.. About Sanford-Burnham Medical Research Institute Sanford-Burnham Medical Research Institute (formerly Burnham Institute for Medical Research) is dedicated to discovering the fundamental molecular causes of disease and devising the innovative therapies of tomorrow. Sanford-Burnham, with operations in California and Florida, is one of the fastest-growing research institutes in the country. The Institute ranks among the top independent research institutions nationally for NIH grant funding and among the top organizations worldwide for its research impact. From 1999 - 2009, ...

To accomplish our study aims, we will conduct a non-randomized phase II trial of AI alone as anastrozole in combination with sulindac in postmenopausal women with early stage ER+ breast cancer who are receiving an anastrozole as their adjuvant hormonal therapy. Recruitment will be limited to women on anastrozole to reduce heterogeneity introduced by other AIs. Anastrozole is selected as it is the only AI available in generic form and currently comprises almost 100% of our patient population. Approximately 100 breast cancer patients, stable on AI therapy (minimum of 3 months) for the treatment of their breast cancer will receive sulindac 150 mg bid for 12 months. Breast imaging will be conducted at baseline, 3, 9 and 15 months. A one-month run-in period followed by a 3-month observation, no agent period will be used to identify subjects likely not to adhere to the study regimen and to determine the extent of variability in breast density over time.. The primary endpoint of the study will be ...

CheckOrphan is a non-profit organization located in Basel, Switzerland and Santa Cruz, California that is dedicated to rare, orphan and neglected diseases. CheckOrphan offers users an interactive and dynamic platform for all these diseases. This strategy allows visitors to be updated daily on all the latest news and interact with people internationally. This is essential, because due to the nature of these diseases, there is not a large concentration of individuals within any given proximity ...

This medication is typically used twice a day. However, your doctor or pharmacist may have suggested a different schedule that is more appropriate for you. Depending on the treated condition, it may be used regularly or only as needed. Follow the instructions provided by your doctor or pharmacist. Important: Follow the instructions on the label. Do not use more of this product, or more often, than prescribed. This medication may irritate the stomach, and should be taken with food. It is best to avoid coffee, spicy food or alcohol. ...

Transferrin (Tf) is an important iron-binding protein postulated to try out an integral role in iron ion (Fe) absorption via the Tf receptor (TfR), which potentially plays a part in the pathogenesis of Alzheimers disease (Advertisement). 2a (n2a) cells and rat principal cortical neurons with inhibitors of COX-2, including flurbiprofen and sulindac sulfide, reduced the secretion of A1-42 and A1-40 within a dose-dependent way. This observation was confirmed in APP/PS1 Tg Rabbit polyclonal to Caspase 7 mice [26] further. To exclude the nonspecificity of COX-2 inhibitors, Xiang [27] uncovered that individual COX-2 appearance in APP/PS1/COX-2 mice induced potentiation of human brain parenchymal amyloid plaque (AP) development and produced a larger than 2-collapse upsurge in PGE2 creation at age 24 months. Consistent with these observations [27], Akitake [28] recommended that mPGES-1, a PGE2 synthase, is certainly induced in individual Advertisement patients as well as the Tg2576 Rasagiline 13C3 ...

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Sp transcription factors Sp1, Sp3 and Sp4 are highly expressed in cancer cells/tumors and Sp1 is a negative prognostic factor for survival of gastric and pancreatic cancer and glioma patients [43-45]. Although Sp1 and other Sp proteins are important for early embryonic and postnatal development in mice, their expression is relatively low in adult tissues and there is evidence that Sp1 expression decreases with age in rodents and humans [46-48]. The functional importance of Sp1, Sp3 and Sp4 in cancer cells has been confirmed by RNA interference (RNAi) showing that knockdown of Sp transcription factors Sp1, Sp3 and Sp4 (singly or combined) decreases cell proliferation, survival, angiogenesis and inflammation [26, 35, 36, 42]. These results are consistent with identification (by RNAi) of several pro-oncogenic Sp-regulated genes important for cell growth (cyclin D1, EGFR, c-Met), survival (bcl-2, survivin), angiogenesis (VEGF and VEGF receptors), and inflammation (p65 subunit of NFκB) [22, 23, 26, ...

Abstract: : Purpose: The degeneration of retinal neurons results in loss of vision. It has been known that Non Steroidal Anti-Inflammatory Drugs (NSAIDs) can protect the neuron from ischemic damage. The purpose of this study was to investigate the protective effect of NSAIDs in the rat retinal ischemia. Methods: Retinal ischemia in Sprague Dawley rats was induced by high intraocular pressure at 160 mmHg for 60 minutes after intra-ocular injection of saline, aspirin (5 to 20 mM), sulfasalazine (1 to 5 mM) or sulindac (0.01 to 0.1 mM). For morphological study, the retinas were embedded in epon 24 hours after ischemic injury. To determine neuronal survivorship in the retinal layers, the number of viable neurons was counted in 100µm X 25µm square and examined. Results: The intravitreal injections of aspirin, sulfasalazine or sulindac attenuated the ischemic neuronal degeneration in dose dependent. The protective effect of aspirin at concentration of 20 mM was observed to be 73%5.4 and 80%2.5 in ...

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Non steroidal antiinflammatory drugs. Are very nephrotoxic in the presence of dehydration and renal failure.. Prostaglandins play a major role in haemodynamic regulation in the kidney and in the excretion of water and electrolytes. All the NSAIDS inhibit PG synthesis.. Prostaglandins have an important role in conducting renal blood flow by counteracting the vasoconstrictive influence of compounds such as angiotensin II Under these circumstances, inhibition of PG synthesis could cause a marked decrease in renal blood flow by removing this compensatory vasodilatation.. In CRF the use of Clinoril (sulindac) is the safest when an antiprostaglandin is needed. (it has less effect on renal function than the others.). ...

Probiotics are of great value to our overall health as outlined in the following study. There are a variety of conditions in which the use of pro-biotics has proven effective:diarrhoea with its various causes, inflammatory bowel diseases, irritable bowel disease, colon cancer chemoprevention and hepato-portal encefalopathy. The pro-biotics have shown to be a promising therapeutical […]. ...

Probiotics are of great value to our overall health as outlined in the following study. There are a variety of conditions in which the use of pro-biotics has proven effective:diarrhoea with its various causes, inflammatory bowel diseases, irritable bowel disease, colon cancer chemoprevention and hepato-portal encefalopathy. The pro-biotics have shown to be a promising therapeutical […]. ...