A full-length aryl sulfotransferase cDNA was isolated from a human liver cDNA library. It was 1155 bp long containing a coding region of 885 basepairs encoding a cytosolic protein (Mr 34178 Da) of 295 amino acids. This human cDNA shared 80% homology to the rat aryl sulfotransferase cDNA, 58% to the bovine and rat oestrogen sulfotransferase cDNAs, 53% to the rat hydroxysteroid sulfotransferase cDNA and 51% to the human liver dehydroepiandrosterone sulfotransferase cDNA over its whole 885 bp coding region. The deduced amino acid sequence of this human cDNA was 79% homologous to that of the rat aryl sulfotransferase cDNA and the putative common-substrate binding site motif GXXGXXK of the sulfotransferases has been conserved in this human amino acid sequence. At least two sizes of this human aryl sulfotransferase mRNA were detected in the human liver and lung ...
TY - JOUR. T1 - Indirect regulation of human dehydroepiandrosterone sulfotransferase family 1A member 2 by thyroid hormones. AU - Huang, Ya Hui. AU - Lee, Yi Chih. AU - Tai, Pei Ju. AU - Yen, Chun Che. AU - Liao, Chu Yu. AU - Chen, Wei Jan. AU - Liao, Cheng Jung. AU - Cheng, Wan Li. AU - Chen, Ruey Nan. AU - Wu, Sheng Ming. AU - Wang, Chia Siu. AU - Lin, Kwang Huei. PY - 2006/5. Y1 - 2006/5. N2 - Thyroid hormone, T3, regulates cell metabolism, differentiation, and development. cDNA microarrays were performed to study the mechanism of target gene regulation after T3 treatment in a thyroid hormone receptor-α (TRα)-overexpressing hepatoma cell line (HepG2-TRα). The differentially expressed target genes are several metabolic enzymes, including dehydroepiandrosterone-sulfotransferase family 1A member 2 (SULT2A1). Enzyme SULT2A1 was elevated roughly 5-fold at the protein level and 9-fold increase at the mRNA level after 48 h T3 treatment in HepG2-TRα cells. Cycloheximide inhibited T3-induced ...
We previously reported that the administration of dexamethasone to adult male rats significantly induced SULT2 mRNA and protein levels in the liver (Runge-Morris et al., 1996). In primary cultured rat hepatocytes, SULT2 mRNA expression continued to increase as the dexamethasone dose was augmented from 10−8 to 10−5 M (Runge-Morris et al., 1996). These findings contrasted sharply with those obtained for expression of tyrosine aminotransferase, a gene that is regulated via a classical glucocorticoid receptor-mediated mechanism (Shinomiya et al., 1984). In hepatocytes, lower doses of dexamethasone (10−8M compared with 10−5 M) produced more substantial increases in tyrosine aminotransferase mRNA expression, and cotreatment with dexamethasone and the glucocorticoid receptor antagonist RU486 had a greater inhibitory effect on dexamethasone-induced tyrosine aminotransferase than on dexamethasone-induced SULT2 mRNA expression (Runge-Morris et al., 1996). These data implicated the involvement of ...
Cholesterol sulfate has been shown to be a normal constituent of blood platelets and to modulate platelet function.11 For example, it potentiates ADP- and thrombin-induced platelet aggregation as well as serotonin secretion. These effects are specific for cholesterol sulfate and require both the sterol ring structure as well as the sulfate moiety.11 Furthermore, cholesterol sulfate modulates arachidonic acid metabolism while potentiating arachidonic acid-induced platelet aggregation, effects that are, in part, explained by changes in calcium flux.17 It has also been shown that platelets will adhere to cholesterol sulfate but not to cholesterol, other cholesterol esters, or other steroid sulfates under flow conditions similar to those seen in arteries.12. It is now appreciated that SULT2B1b is the physiological cholesterol sulfotransferase.21 SULT2B1b is selectively expressed in specific tissues, where it is known that cholesterol sulfate plays an important physiological role, eg, skin.25 We now ...
Hydroxysteroid sulfotransferase 2B1b (SULT2B1b) sulfates cholesterol and oxysterols. Hepatic oval cells (HOCs), thought to be progenitor cells, can be triggered in chemically injured livers. The...
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Dermatan 4-sulfotransferase (EC 2.8.2.35, dermatan-specific N-acetylgalactosamine 4-O-sulfotransferase, dermatan-4-sulfotransferase-1, dermatan-4-sulfotransferase 1, D4ST-1, dermatan N-acetylgalactosamine 4-O-sulfotransferase, CHST14 protein, CHST14) is an enzyme with systematic name 3-phospho-5-adenylyl sulfate:(dermatan)-N-acetyl-D-galactosamine 4-sulfotransferase. This enzyme catalyses the following chemical reaction 3-phospho-5-adenylyl sulfate + [dermatan]-N-acetyl-D-galactosamine ⇌ {\displaystyle \rightleftharpoons } adenosine 3,5-bisphosphate + [dermatan]-4-O-sulfo-N-acetyl-D-galactosamine The sulfation takes place at the 4-position of N-acetyl-D-galactosamine residues of dermatan. Evers, M.R.; Xia, G.; Kang, H.G.; Schachner, M.; Baenziger, J.U. (2001). "Molecular cloning and characterization of a dermatan-specific N-acetylgalactosamine 4-O-sulfotransferase". J. Biol. Chem. 276: 36344-36353. doi:10.1074/jbc.M105848200. PMID 11470797. Mikami, T.; Mizumoto, S.; Kago, N.; Kitagawa, ...
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Heparin has a higher content of N-sulfated glucosamine and L-iduronic acid than heparan sulfate. Deacetylation of N-acetylglucosamine followed by N-sulfation may be important steps differentiating the biosynthesis of these glycosaminoglycans. We have cloned, by cross-hybridization with the cDNA from rat liver heparan sulfate N-deacetylase/N-sulfotransferase, a protein from a heparin synthesizing mastocytoma derived cell line called MST. This protein, which has both N-deacetylase/N-sulfotransferase activities, has a predicted amino acid sequence homology of 70% with the above rat liver enzyme and is unique for the following reasons. 1) It was found to be encoded by a 3.8-kilobase mRNA that was unique to heparin-producing cells; an 8.5-kilobase mRNA encoding the rat liver enzymes has been found to occur in all mammalian cells tested on the basis of nucleic acid cross-hybridization; 2) the protein overexpressed in COS cells in its full-length transmembrane form or as a soluble secreted protein A chimera
Research has shown that the enzymes and proteins encoded by DSEL (dermatan sulfate epimerase-like), EXTL1 (exostoses (multiple)-like 1), HS6ST1 (heparan sulfate 6-O-sulfotransferase 1), HS6ST3 (heparan sulfate 6-O-sulfotransferase 3), NDST3 (N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3), and SULT1A1 (sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1), are involved in heparan sulfate and heparin metabolism [1]. Both heparan sulfate and heparin are members of the glycosaminoglycan family of carbohydrates that are very closely related in structure. As reviewed by Kolset and Salmivirta [2], cell surface heparan sulfate proteoglycans play biological roles in several aspects of lipoprotein metabolism. For example, the binding of lipoproteins to heparan sulfate presents an important process for the cellular uptake and turnover of lipoproteins. Heparan sulfate also serves as a primary interaction site for lipoprotein lipase and hepatic lipase on cell surfaces and ...
Cytosolic Sulfotransferase 4A1/SULT4A1 Overexpression Lysate (Native). Tested Reactivity: Hu. Validated: WB. Backed by our 100% Guarantee.
Carbohydrate sulfotransferase 14 is an enzyme that in humans is encoded by the CHST14 gene. CHST14, a protein-coding gene, encodes for the enzyme carbohydrate sulfotransferase 14 (CHST14)/ dermatan 4-O-sulfotransferase (D4ST1). In humans, CHST14 is positioned on the long arm (q) of chromosome 15 at position 15.1, from base pair 40,470,961 to base pair 40,474,571. The CHST14 gene is 3,611 bases long, composed of 376 amino acids, and has a molecular mass of 42997 Da. CHST14 is implicated in fetal development of connective tissues throughout multiple organ systems. It is also implicated in regulation of proliferation and neurogenesis of neural precursor cells. CHST14 has been linked to inhibition of peripheral nerve regeneration in adults. Dermatan 4-O-sulfotransferase enzymatically transfers an active sulfate to position 4 of N-acetyl-D-galactosamine residues of dermatan sulfate, stabilizing this glycosaminoglycan. Dermatan sulfate is essential to extracellular matrix formation and is found in ...
Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues and O-linked sugars of mucin-type acceptors. Acts on the non-reducing terminal GlcNAc of short carbohydrate substrates. However, it does not transfer sulfate to longer carbohydrate substrates that have poly-N-acetyllactosamine structures. Has no activity toward keratan. Not involved in generating HEV-expressed ligands for SELL. Its substrate specificity may be influenced by its subcellular location ...
Methyl 3-O-(N-acetyl-β-D-glucosaminyl)-β-D-galactopyranoside has been shown to inhibit rat lung lectin, as well as the attachment of Streptococcus pneumoniae and H. inf
glycolithocholate sulfate = N-(3α-sulfooxy-5β-cholan-24-oyl)glycine. Other name(s): BAST I; bile acid:3-phosphoadenosine-5-phosphosulfate sulfotransferase; bile salt:3phosphoadenosine-5-phosphosulfate:sulfotransferase; bile acid sulfotransferase I; glycolithocholate sulfotransferase. Systematic name: 3-phosphoadenylyl-sulfate:glycolithocholate sulfotransferase. Comments: The formation of sulfate esters of bile acids is an essential step in the prevention of toxicity by monohydroxy bile acids in many species [3]. This enzyme is both a bile salt and a 3-hydroxysteroid sulfotransferase. In addition to the 5β-bile acid glycolithocholate, deoxycholate, 3β-hydroxy-5-cholenoate and dehydroepiandrosterone (3β-hydroxyandrost-5-en-17-one) also act as substrates [see also EC 2.8.2.2 (alcohol sulfotransferase) and EC 2.8.2.34 (glycochenodeoxycholate sulfotransferase)]. May be identical to EC 2.8.2.2 [3].. Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: ...
Human cytosolic sulfotransferase SULT1E1 catalyzes the sulfation of estrogens and estrogenic drugs in human reproductive tissues. Logically, this estrogen-preferring sulfotransferase isoform could play a regulatory role in estrogen signaling activities in human reproductive cells, including the prostate cells. This hypothesis was tested using DNA microarray and real-time reverse transcription-polymerase chain reaction methods in the present work. Potential changes in the transcriptional expression of selected signal transduction-related genes in human prostate cancer CA-HPV-10 cell line after SULT1E1 transfection were examined by DNA microarray methods. Notable changes were observed in the mRNA expression levels of TFRC, a cell membrane transferrin receptor gene, and TMEPAI, a gene encoding a steroid-dependent mRNA product. Expression of TFRC was down-regulated, whereas expression of TMEPAI was up-regulated by SULT1E1 transfection in CA-HPV-10 cells. Data from the current studies also showed ...
Androgens and estrogens increase the number of cell division and the opportunity for random genetic errors and are thus involved in carcinogenesis of hormone related cancers. [...]
Antibody-based assay for N-deacetylase activity of heparan sulfate/heparinN-deacetylase/N-sulfotransferase (NDST): novel characteristics of NDST-1and -2. ...
Glycosaminoglycans (GAGs) are the major constituents of the extracellular matrix that control the transport and signaling of numerous growth factors (Hacker et al., 2005). Consisting of 50-400 repeats of disaccharide units, GAGs can be divided by their composition, sulfation and epimerization into chondroitin sulfate (CS), dermatan sulfate (DS), heparan sulfate (HS)/heparin, and keratan sulfate (KS). A common precursor of all GAGs is UDP-glucuronic acid, which is synthesized from UDP-glucose by a single mammalian enzyme, UDP-glucose dehydrogenase (Ugdh). Together with an amino sugar such as N-acetylglucosamine for HS and N-acetylgalactosamine for CS, these monosaccharides are incorporated by polymerization enzymes into the backbone of the polysaccharide and are further modified by a series of sulfotransferase enzymes (Esko and Selleck, 2002). For example, the polymerization of HS is exclusively catalyzed by Ext enzymes, which are followed by N-deacetylase/N-sulfotransferase (Ndst) enzymes to ...
Heparan sulfate (HS), a linear negatively charged polysaccharide located at the cell surface and in the extracellular matrix, interacts with, and thereby regulates the functions of numerous proteins. HS-protein interactions depend on the fine structure of HS, especially its sulfation pattern. This thesis aimed to understand how differently sulfated domains in HS are generated. Specifically, the substrate specificities of HS hexuronic acid 2-O-sulfotransferase (2OST) and HS glucosaminyl 6-O-sulfotransferases (6OSTs) were investigated. Three different 6OSTs (6OST1-3) have been cloned and characterized. To study the mechanisms controlling 6-O-sulfation we incubated the recombinant purified 6-OST isoforms with different 6-O-desulfated poly- and oligosaccharide substrates and the active sulfate donor 3-phosphoadenosine 5-phospho[35S]sulfate (35S-labeled PAPS). All three enzymes catalyzed 6-O-sulfation of both N-acetylated (GlcNAc) as well as N-sulfated (GlcNS) glucosamines next to a nonreducing ...
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Accepted name: estrone sulfotransferase. Reaction: 3-phosphoadenylyl sulfate + estrone = adenosine 3,5-bisphosphate + estrone 3-sulfate. Glossary: 3-phosphoadenylyl sulfate = PAPS. Other names: 3-phosphoadenylyl sulfate-estrone 3-sulfotransferase; estrogen sulfotransferase; estrogen sulphotransferase; oestrogen sulphotransferase; 3-phosphoadenylylsulfate:oestrone sulfotransferase. Systematic name: 3-phosphoadenylyl-sulfate:estrone 3-sulfotransferase. Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9026-06-6. References:. 1. Adams, J.B. and Poulos, A. Enzymic synthesis of steroid sulphates. 3. Isolation and properties of estrogen sulphotransferase of bovine adrenal glands. Biochim. Biophys. Acta 146 (1967) 493-508. [PMID: 4965224]. 2. Rozhin, J., Zemlicka, J. and Brooks, S.C. Studies on bovine adrenal estrogen sulfotransferase. Inhibition and possible involvement of adenine-estrogen stacking. J. Biol. Chem. 252 (1967) 7214-7220.. 3. Adams, J.B., Ellyard, ...
Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estrogen sulfotransferase activity. responsible for the sulfonation and activation of minoxidil. Is Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk (By similarity).
A novel mouse liver-sulfotransferase like (mL-STL) gene was firstly identified in our laboratory with unknown physiological function. Computer assisted analysis revealed that the mL-STL gene encodes a complete cytosolic sulfotransferase (SULT) domain. SULT is a superfamily of enzymes that catalyze the transfer of a sulfate group from a cofactor, 3-phosphoadenosine 5-phosphosulfate (PAPS) to the hydroxyl group or amino group of substrates in a process called sulfonation. Different SULT family members recognize specific subsets of substrates. Dendrogram analysis indicated that the mL-STL protein shares a high amino acid sequence similarity with the SULT2A subfamily, which is known to sulfonate hydroxysteroids. This result suggests that the mL-STL protein can catalyze the SULT2A substrates. However, further study is required to confirm the substrate specificity of the mL-STL protein.. The first objective of my study is to characterize whether the mL-STL protein is a functional cytosolic SULT ...
Human galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 2 ELISA Kit;Human GST-2 ELISA Kit;Human N-acetylglucosamine 6-O-sulfotransferase 1 ELISA Kit;Human glcNAc6ST-1 ELISA Kit;Human Gn6ST-1 ELISA Kit;Human GN6ST ELISA Kit;Human C6ST ELISA Kit;Human GST2 ELISA Kit;Human HEL-S-75 ELISA Kit;Human carbohydrate sulfotransferase 2 ELISA Kit;Human carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2 ELISA Kit;Human carbohydrate (chondroitin 6/keratan) sulfotransferase 2 ELISA Kit;Human epididymis secretory protein Li 75 ELISA Kit ...
Mouse Monoclonal Anti-Cytosolic Sulfotransferase 1C2/SULT1C2 Antibody (4G1). Validated: WB, Flow, IHC, IHC-P. Tested Reactivity: Human. 100% Guaranteed.
Background: Heparan sulfate proteoglycans act as co-receptors for a number of chemokines that are integral to the process of vascular remodeling in response to injury. Heparan sulfate sulfation plays a critical role in conferring specificity to chemokine binding and activity. Previous data from our laboratory demonstrated that wire injury in femoral artery of wild type mice induced a 20 fold increase at 14 days and 40 fold increase at 28 days in N-deactylase/N-sulfotransferase-1 (NDST1) transcript, an enzyme catalyzing the initial N-sulfation of HS side chains.. Hypothesis: Alterations in heparan sulfate sulfation would disrupt chemokine binding and influence vascular remodeling in the setting of injury. To test our hypothesis we established a genetic mouse model in which NDST1 was deleted in smooth muscle cells using a crelox approach (smMHCcre/eGFP/NDST1flox).. Results: Characterization of this model exhibited a significant decrease in NDST1 mRNA and in the ratio of mono-N-sulfated/unsulfated ...
TY - JOUR. T1 - Characterization of expression of glycan ligands for Siglec-F in normal mouse lungs. AU - Guo, Jin P.. AU - Brummet, Mary E.. AU - Myers, Allen C.. AU - Na, Ho Jeong. AU - Rowland, Elizabeth. AU - Schnaar, Ronald L.. AU - Zheng, Tao. AU - Zhu, Zhou. AU - Bochner, Bruce S.. PY - 2011/2/1. Y1 - 2011/2/1. N2 - Sialic acid-binding immunoglobulin-like lectin (Siglec)-F, an inhibitory receptor on mouse eosinophils, preferentially recognizes the glycan ligand 69-sulfated sialyl Lewis X, but little is known about the requirements for its lung expression. RT-PCR and immunohistochemistry were used to detect and localize the sulfotransferase keratin sulfate galactose 6-O sulfotransferase (KSGal6ST, alsoknown as carbohydrate sulfotransferase 1; gene name, Chst1) that is putatively required for 6′-sulfated Sialyl Lewis X synthesis. RT-PCR detected the greatest constitutive expression of Chst1 in lung, liver, andspleen tissue.Immunohistochemistry localized the expression of KSGal6ST in lung ...
The formation of sulfate esters of bile acids is an essential step in the prevention of toxicity by monohydroxy bile acids in many species [3]. This enzyme is both a bile salt and a 3-hydroxysteroid sulfotransferase. In addition to the 5beta-bile acid glycolithocholate, deoxycholate, 3beta-hydroxy-5-cholenoate and dehydroepiandrosterone (3beta-hydroxyandrost-5-en-17-one) also act as substrates [see also EC 2.8.2.2 (alcohol sulfotransferase) and EC 2.8.2.34 (glycochenodeoxycholate sulfotransferase)]. May be identical to EC 2.8.2.2 [3 ...
Embryonic mouse skin undergoes a drastic morphological change from 13 to 16 gestational days, i.e., formation of rudiments of hair follicles and stratification and cornification of interfollicular epidermis. To investigate underlying molecular mechanisms of the morphogenesis, an organ culture system was established that allows skin tissues isolated from 12.5- or 13.5-days postcoitus embryos to develop in a manner that is histologically and temporally similar to the process in vivo. Expression of differentiation markers of epidermal keratinocytes including cholesterol sulfotransferase and cytokeratin K1, was induced in culture, since it also occurs in vivo. The morphogenic process was observed by time-lapse videomicrography. In this culture system, epidermal growth factor (Egf) and transforming growth factor alpha specifically and completely inhibit the hair follicle formation with marginal effects on interfollicular epidermis. The inhibitory action by Egf is reversible and stage specific, i.e., ...
NDST2 overexpression lysate, 0.1 mg. Transient overexpression lysate of N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2 (NDST2)
Estrogen sulfotransferase (EST) is a cytosolic enzyme that catalyzes the sulfonation of estrogens at the 3-hydroxyl position by use of 3′-phosphoadenosine-5′-phosphosulfate as an activated sulfate donor. Although largely known and studied as a phase II metabolic enzyme with prominent expression in the liver, the high substrate specificity of EST (with a highVmax/Km value for estrogen) suggests that expression of the enzyme in extrahepatic, estrogen target tissues, such as the breast epithelium, may constitute an effective mechanism for local estrogen regulation as well. In this study, we have evaluated the physiological significance of EST expression by cDNA transfection studies with use of the estrogen-dependent MCF-7 breast cancer cell line as a model system. We show that expression of EST in MCF-7 cells effectively reduces the cells response to physiological concentrations of estradiol (10 nM) by up to 70% as determined in an estrogen-responsive reporter gene assay. In addition, we ...
Human B-cell RAG-associated gene protein ELISA Kit;Human hBRAG ELISA Kit;Human N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase ELISA Kit;Human GALNAC4S-6ST ELISA Kit;Human BRAG ELISA Kit;Human GALNAC4S6ST ELISA Kit;Human KIAA0598 ELISA Kit;Human carbohydrate sulfotransferase 15 ELISA Kit;Human B cell RAG associated protein (GALNAC4S-6ST) ELISA Kit;Human carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 ELISA Kit ...
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Next to deiodination, glucuronidation and sulfation of the phenolic hydroxyl group are important pathways of iodothyronine metabolism. Although in general conjugation serves to facilitate the urinary and biliary excretion of lipophilic substances, sulfation of thyroid hormones has another important function. Sulfation protects the tissues against an excess of active thyroid hormone and it can also be used as a reservoir from which active hormone is released by sulfatases when and where it is required. Interaction between sulfation and deiodination has already been described in several mammalian tissues. After an initial characterization of the sulfotransferases we determined the changes in sulfation during chicken embryonic development and induced metamorphosis of the axolotl, a neotenous amphibian. Sulfation assays demonstrate the presence of sulfotransferases in liver, kidney and brain cytosol in one-day-old chicken. Similar to the situation in mammals, the enzyme(s) show a substrate preference for 3
Predicted to have N-acetylgalactosamine 4-O-sulfotransferase activity. Predicted to be involved in dermatan sulfate biosynthetic process. Predicted to localize to the Golgi apparatus and integral component of membrane. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome. Is expressed in several structures, including brain; liver; and retina. Orthologous to human CHST14 (carbohydrate sulfotransferase 14 ...
Sigma-Aldrich offers abstracts and full-text articles by [Ding Xu, Vaibhav Tiwari, Guoqing Xia, Christian Clement, Deepak Shukla, Jian Liu].
Complete information for CHST5 gene (Protein Coding), Carbohydrate Sulfotransferase 5, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
Complete information for CHST14 gene (Protein Coding), Carbohydrate Sulfotransferase 14, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
This book consists of five sections including 25 chapters written by an international group of authors. The volume covers proteoglycan function, infection, immunity, carbohydrate-binding proteins including galectin, and new developments including O-glycosylation in Notch and related signaling.. Section I (chapters 1-4) highlights proteoglycans and sulfotransferases. There are data and discussions related to proteoglycan signaling networks, roles of Drosophila glypican, various assays for measuring sulfatase activity, and analysis of heparan sulfate structure and biological activity.. Section II (chapters 5-13) is devoted to lectins, immunity, and infection. Special chapters of this section include microbe-associated molecular patterns in innate immunity, structural and functional analysis of glycosphingolipids of Schistosoma mansoni, analysis of biotoxicity of body lectins and other cytoplasmic proteins, lectins of endoplasmic reticulum with homology with mannose-6-phosphate receptors, and ...
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Tytuł projektu: Udostępnianie cyfrowe zasobów polskich czasopism z nauk przyrodniczych i rolniczych w bazie AGRO. Nr umowy: POPC.02.03.01-00-0038/18-00 (okres realizacji 2018-2021). Kwota dofinansowania: 7 442 980,00 z. W ramach Programu Operacyjnego Polska Cyfrowa na lata 2014-2020, Oś Priorytetowa nr 2 "E-administracja i otwarty rząd" Działanie nr 2.3 "Cyfrowa dostępność i użyteczność informacji sektora publicznego" Poddziałanie nr 2.3.1 "Cyfrowe udostępnienie informacji sektora publicznego ze źródeł administracyjnych i zasobów nauki (typ projektu: cyfrowe udostępnienie zasobów nauki)" Instytucja Finansująca: Centrum Projektów Polska Cyfrowa ...
This paper addresses the hypothesis that the expression of members of the NDST enzyme family can vary between different cell types and following stimulation by pro-inflammatory cytokines. The immortalized human microvascular endothelial cell line HMEC-1 was used to model the effect of cytokine-mediated regulation of NDST expression on the abundance of sulphated domains within HS on the surface of the vascular endothelium. This was followed by an examination of changes in the potential of these cells to bind exogenous RANTES at their apical surface and subsequent analysis of changes in the biological activity of this chemokine. The HMEC-1 cell line was chosen for this work as it provides a reproducible system which has previously been validated to model aspects of the immunobiology of microvascular endothelium including the uniform response to pro-inflammatory cytokines (Goebeler et al., 1997) and the presentation of antigens to specific T cells (Bosse et al., 1993). In addition, HMEC-1 cells are ...
TY - JOUR. T1 - Differential expression of regucalcin (SMP30) and its function in hypoxic cardiomyocytes. AU - Lim, Soyeon. AU - Song, Byeong Wook. AU - Cha, Min Ji. AU - Choi, Eun Ju. AU - Ham, On Ju. AU - Lee, Chang Yeon. AU - Choi, Seong Yong. AU - Lee, Se Yeon. AU - Jang, Yangsoo. AU - Hwang, Ki Chul. PY - 2009/10/1. Y1 - 2009/10/1. N2 - Regucalcin (SMP30) has been proposed to be involved in the maintenance of calcium homeostasis. Although the expression of regucalcin was regulated in the liver and kidney during the embryogenesis and maturation of these tissues, the roles of regucalcin were not defined yet in heart. This study focused on the investigation of the differential expression changes in regucalcin and its function in hypoxic cardiomyocytes. The expression level of regucalcin was the highest in 7 days after neonatal stage of rat heart. In hypoxic condition, reactive oxygen species (ROS) production and calcium level were decreased in regucalcin-over expressed cardiomyocytes about 60% ...
GAL3ST4 - Galactose-3-O-sulfotransferase 4; Catalyzes the transfer of sulfate to beta-1,3-linked galactose residues in O-linked glycoproteins. Good substrates include asialofetuin, Gal-beta-1,3-GalNAc and Gal-beta-1,3 (GlcNAc-beta-1,6)GalNAc; Sulfotransferases, membrane bound [a.k.a. PP6968, ENSP00000398304, ENSP00000353142, ENSP00000292377] ...
Free Online Library: Homogenous and heterogeneous sulfonation of polymers: a review. by Polymer Engineering and Science; Engineering and manufacturing Science and technology, general Polymers Analysis Substitution reactions
View mouse Chst15 Chr7:132235780-132317228 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression
Sigma-Aldrich offers abstracts and full-text articles by [Xiaojuan Chai, Yan Guo, Mengxi Jiang, Bingfang Hu, Zhigang Li, Jie Fan, Meihong Deng, Timothy R Billiar, Heidi R Kucera, Nilesh W Gaikwad, Meishu Xu, Peipei Lu, Jiong Yan, Haiyan Fu, Youhua Liu, Lushan Yu, Min Huang, Su Zeng, Wen Xie].
Cell structureCell envelopeBiosynthesis and degradation of surface polysaccharides and lipopolysaccharidespoly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB (TIGR03938; EC 3.5.1.-; HMM-score: 110.6) ...