The toxicity exerted by the antibiotic sulfadiazine on the growth of soil bacterial communities was studied in two agricultural soils for a period of 100 days. In the short-term (2 days of incubation), the effect of sulfadiazine on bacterial growth was low (no inhibition or inhibition <32% for a dose of 2000 mg·kg−1). However, sulfadiazine toxicity increased with time, achieving values of 40% inhibition, affecting bacterial growth in both soils after 100 days of incubation. These results, which were here observed for the first time for any antibiotic in soil samples, suggest that long-term experiments would be required for performing an adequate antibiotics risk assessment, as short-term experiments may underestimate toxicity effects.

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Deoxyribonucleate (DNA) preparations were extracted from Neisseria meningitidis (four isolates from spinal fluid and blood) and N. gonorrhoeae strains, all of which were resistant to sulfadiazine upon primary isolation. These DNA preparations, together with others from in vitro mutants of N. meningitidis and N. perflava, were examined in transformation tests by using as recipient a drug-susceptible strain of N. meningitidis (Ne 15 Sul-s Met+) which was able to grow in a methionine-free defined medium. The sulfadiazine resistance typical of each donor was introduced into the uniform constitution of this recipient. Production of p-aminobenzoic acid was not significantly altered thereby. Transformants elicited by DNA from the N. meningitidis clinical isolates were resistant to at least 200 μg of sulfadiazine/ml, and did not show a requirement for methionine (Sul-r Met+). DNA from six strains of N. gonorrhoeae, which were isolated during the period of therapeutic use of sulfonamides, conveyed lower degrees

Pyrimethamine/Trimethoprim/Sulfadiazine Oral Suspension may be prescribed for EPM. Pyrimethamine/Trimethoprim/Sulfadiazine preparation information is provided by Wedgewood Pharmacy.

A pharmacokinetic and bioavailability study of sulfadiazine combined with trimethoprim (sulfadiazine/trimethoprim) was carried out in fifteen healthy young ostriches after intravenous (i.v.), intramuscular (i.m.) and oral administration at a total dose of 30 mg/kg body weight (bw) (25 and 5 mg/kg bw …

1. Two hundred cases of pneumonia in Bantu patients were allotted in strict rotation to one of 3 treatment schedules in which cases were treated with penicillin, sulphadiazine or a combination of these remedies. The groups were comparable in respect of age, sex, mean duration of illness before admission, mean temperature at the commencement of treatment, and the anatomical distribution of lesions. 2. The sputum bacteriology was obtained in 107 cases and in 82 of these the sensitvity in vitro of the causative bacteria towards 6 commonly used antibiotics was determined. It was found that very few of the bacteria isolated were resistant to terramycin, chloramphenicol or aureomycin, while approximately a quarter were resistant to penicillin and sulphadiazine. 3. There was no statistically significant difference in the results obtained by the 3 methods of treatment although the mean duration of pyrexia was longest in the combined treatment group; nor was there any increase in failures found in the groups in

Sulphadiazine is a broad spectrum antibiotic used as a feed additive for intensively farmed animals to prevent the spread of disease. The Randox Food Diagnostics Sulphadiazine ELISA test kit offers screening for antibiotic residues across a range of food and veterinary matrices.. ...

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Author: Arens, James ; Barnes, Karen ; Crowley, Nicola ; Maartens, Gary Date: 2007 We conducted a retrospective study of AIDS-associated cerebral toxoplasmosis. Eighteen patients received pyrimethamine plus sulfadiazine and 25 co-trimoxazole, with comparable baseline characteristics. There were no differences in clinical ... Read more ...

In this study, Sulfadiazine reacted with (NaNO2)and (HCl) to form diazonum salt was converted to 4-azido-N-(pyrimidin-2-yl)phenylsulfonamid (An) by reaction with sodium azide. 1,2,3-triazoline derivatives (B1-B10) were synthesized viaclick reaction, Huisgen 1,3-dipolar cycloadditionbetween compound (An) with chalcones and unsaturated compound like maleicanhydride, acrylamide, p-benzoquinone and cinnamylalcohol in presence cuprous chloride and sodium ascorbate.Identification of products by elemental analysis C.H.N.S., FT-IR spectra and 1H-NMR spectrum. 1,2,3-triazoline derivatives compounds were screened for antibacterial activity.. ...

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Sulfadiazine prescription and dosage sizes information for physicians and healthcare professionals. Pharmacology, adverse reactions, warnings and side effects.

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Sulfadiazine (2-sulfanilamidopyrimidine), the pyrimidine analogue of sulfapyridine and sulfathiazole, is one of a group of heterocyclic derivatives of sulfanila

I read with interest the recent article by Cabreet al.1 I make three comments on the section of the review pertaining to HIV disease. I disagree with the statement made on page 551 that chorea is pathognomonic of toxoplasmosis encephalitis in patients with AIDS. Chorea may also occur in patients with AIDS dementia complex (ADC).2 Secondly, there are several errors in table 2. Fluconazole is not given as 400 mg four times a day for acute cryptococcal meningitis therapy but rather as 400 mg/day; fluconazole is not given as 200 mg four times a day for suppressive therapy but rather as 200 mg/day; pyrimethamine is not given at 50-100 mg four times a day for acute toxoplasmosis therapy nor is folinic acid at 10 mg four times a day or sulfadiazine 4-8 g four times a day but rather pyrimethamine 50-100 mg/day, folinic acid 10 mg/day, and sulfadiazine 4-8 g/day; pyrimethamine for suppressive therapy is not given at 25-75 mg four times a day but rather as 25-75 mg/day and folinic acid should be given at ...

Cats can be treated with a 5-7 day course of sulphamezathine. Antimicrobials such as spiramycin, clindamycin sulphonamides, diphenylsulphones and pyrimenthamine have been shown to be effective against trophozoites and can be used against acute and chronic toxoplasmosis. In humans, the treatment of choice is pyrimethamine plus either trisulphapyrimidines or sulfadiazine. Folic acid is given to avoid the haematological effects of pyrimethamine-induced folate deficiency. Childrens play areas should be protected from cat and dog faeces. Pregnant women should take measures to prevent infection by avoiding contact with cat faeces and avoid working in soil or gardens that could be contaminated by cats, etc. and by thoroughly cooking meat. Hands should be washed after handling raw meat and before eating or touching the face. Vaccines are under development for both humans and animals. ...

The prognosis in cases of pneumococcic meningitis has improved considerably since the advent of the sulfonamides and still more so since penicillin.1, 2, 3, 4, 5, 6, 7, 8 The mortality rate, however, continues to be quite high. Very few individual cases or series of cases treated with penicillin or penicillin and sulfa drugs have been reported. It is anticipated that as more cases are reported and thus more experience gained, further improvement in methods of treatment will follow and in turn a material reduction will result in both mortality and morbidity. ...

Serious blood disorders (agranulocytosis, hepatocellular necrosis, aplastic anemia) have been associated with sulfonamides. Perform complete blood counts. Symptoms of sore throat, fever, pallor, purpura or jaundice may be early signs of serious blood disorders ...

Tell your doctor or health care professional if your symptoms do not improve. You may need to have blood work done while you are taking this medicine.. This medicine can make you more sensitive to the sun. Keep out of the sun. If you cannot avoid being in the sun, wear protective clothing and use sunscreen. Do not use sun lamps or tanning beds/booths.. Drink several glasses of water a day. This will help to reduce possible kidney problems.. This medicine may affect blood sugar levels. If you have diabetes, check with your doctor or health care professional before you change your diet or the dose of your diabetic medicine.. ...

#Wound Care: First and Second Degree Burns by Laurie Swezey RN, BSN, CWOCN, CWS, FACCWS Health care professionals encounter burns in their patient populations frequently, and must be able to differentiate between types of burns. as well as know how to treat burn injuries using current practice standards. The following is an overview of first…

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Analysis Content Specification Analysis Result Identification A: The infrared absorption spectrum; B: The chromatograms; D: The reaction of primary aromatic amines. Meets A,B and D examine Description White, yellowish-white crystalline Meets...

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A lead identification approach using three-dimensional structural models and molecular docking simulations of chemical entities were used to identify 4-(6,7-dimethoxy-9H-1,3,9-triaza-fluoren-4-yl)-piperazine-1-carbothioic acid [4-(pyrimidin-2-ylsulfamoyl)-phenyl]-amide as a small molecule inhibitor of the Aurora kinases. The structural basis for its selective inhibition of Aurora A as predicted by Glide docking is shown. Yellow dashed lines indicate hydrogen bond interactions and the active site backbone of the protein is shown in ribbon form. The pyrimido[5,4-b]indole ring is positioned deep in the ATPbinding site of Aurora A and is involved in non-bonded interactions with Ala213. The 6,7-dimethoxy functional groups are positioned between Lys141 and Glu260 and the pyrimidine ring is in close contact with residues within the hinge region of the protein. The pyrimidine ring, sulfonamide group, and 4-amino phenyl ring of the sulfadiazine moiety favorably occupy the phosphate-binding region of ...

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In order to improve local therapeutic techniques for the massively burnt patients and to minimize the pain associated with dressing change, the concept of topical film was utilized to formulate a topical antimicrobial spray. The commonly used topical antimicrobial silver sulfadiazine spray was formulated as a new drug delivery system. The release of therapeutic agents in vitro from medicated spray formulation was compared with that of the corresponding cream bases, utilizing a modified agar diffusion method. When using Pseudomonas aeroginosa as the test bacteria, silver sulfadiazine was found to produce a significantly larger zones of inhibition when used as the spray formulation instead of the cream form. Silver sulfadiazine spray, left in place for up to one day, appears to be as effective as the twice-daily cleansing and application of silver sulfadiazine cream. Also the periodic stability study of silver sulfadiazine in spray form, which was carried out using TLC, HPLC and particle size analyser

Why is this medication prescribed?. Silver sulfadiazine, a sulfa drug, is used to prevent and treat infections of second- and third-degree burns. It kills a wide variety of bacteria.. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.. How should this medicine be used?. Silver sulfadiazine usually is applied once or twice a day.. Do not apply this drug to infants less than 2 months of age.. Do not stop using silver sulfadiazine until your doctor tells you to do so. Your burn must be healed so that infection is no longer a problem. Gently wash the burned skin area daily to help remove dead skin. If your burn becomes infected or if your infection worsens, call your doctor.. Before applying the medication, clean the burned area and remove any dead or burned skin. Always wear a sterile, disposable glove when you apply silver sulfadiazine. Cover the cleaned burned area with a 1/16-inch (0.2-centimeter) thickness of cream. Keep the burned area ...

Why is this medication prescribed?. Silver sulfadiazine, a sulfa drug, is used to prevent and treat infections of second- and third-degree burns. It kills a wide variety of bacteria.. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.. How should this medicine be used?. Silver sulfadiazine usually is applied once or twice a day.. Do not apply this drug to infants less than 2 months of age.. Do not stop using silver sulfadiazine until your doctor tells you to do so. Your burn must be healed so that infection is no longer a problem. Gently wash the burned skin area daily to help remove dead skin. If your burn becomes infected or if your infection worsens, call your doctor.. Before applying the medication, clean the burned area and remove any dead or burned skin. Always wear a sterile, disposable glove when you apply silver sulfadiazine. Cover the cleaned burned area with a 1/16-inch (0.2-centimeter) thickness of cream. Keep the burned area ...

Silver sulfadiazine is an antibiotic. It fights bacteria and yeast on the skin. Silver sulfadiazine topical (for the skin) is used to treat or prevent serious infection on areas of skin with second- or third-degree burns. Silver sulfadiazine topical may also be used for purposes not listed in this medication guide.

Silver sulfadiazine is an antibiotic. It fights bacteria and yeast on the skin. Silver sulfadiazine topical (for the skin) is used to treat or prevent serious infection on areas of skin with second- or third-degree burns. Silver sulfadiazine topical may also be used for purposes not listed in this medication guide.

Toxoplasmic encephalitis (encephalitis caused by Toxoplasma gondii) is the most frequent cause of focal central nervous system infection in patients with AIDS. If untreated, the encephalitis is fatal. At present, it is standard practice to give a combination of pyrimethamine and sulfadiazine to treat toxoplasmic encephalitis. The high frequency of sulfonamide-induced toxicity in AIDS patients often makes completion of a full course of therapy difficult. There is some information that high doses of parenteral (such as by injection) clindamycin used with pyrimethamine may be as effective as pyrimethamine plus sulfadiazine in the management of the acute phase of toxoplasmic encephalitis in patients with AIDS. Administration of parenteral clindamycin for prolonged periods of time, however, is costly, requires hospitalization, and is inconvenient for the patient. There is some indication that treatment of AIDS patients with acute toxoplasmic encephalitis with oral clindamycin may be effective. ...

Fox and Modak (1974) explored the mechanism of prevention of burn wound infections by silver sulfadiazine. At the time of publication, it had been known for quite a while that silver sulfadiazine (Figure 5) delivered in the form of a topical cream was effective at preventing infections in burn wounds, however it was not known if the antimicrobial activity was due entirely to the silver ions or if the sulfadiazine anion also contributed to the bactericidal effect. Tests from the study showed that sulfadiazine from silver sulfadiazine does not get transported into cells as much as silver. Silver isotopes (110Ag+) were also used to show that silver ions that enter cells complex with DNA. Additionally, the rate at which certain silver containing compounds release silver ions into solution was measured by adding silver compounds to human serum and measuring the amount of unreacted silver compound with increasing time (Figure 6). Notice in Figure 6 how silver sulfadiazine (Ag sulfadiazine) gradually ...

Amikacin/Ketoconazole/Silver Sulfadiazine/Triamcinolone Otic Ointment may be prescribed for Dogs and Cats. Amikacin/Ketoconazole/Silver Sulfadiazine/Triamcinolone preparation information is provided by Wedgewood Pharmacy.

Global and Chinese Silver sulfadiazine Industry, 2016 Market Research Report The Global and Chinese Silver sulfadiazine Industry, 2011-2021 Market Research Report is a professional and - Market research report and industry analysis - 10240259

TY - JOUR. T1 - The effect of a honey based gel and silver sulphadiazine on bacterial infections of in vitro burn wounds. AU - Boekema, B.K.H.L.. AU - Pool, L.. AU - Ulrich, M.. PY - 2013. Y1 - 2013. U2 - 10.1016/j.burns.2012.09.008. DO - 10.1016/j.burns.2012.09.008. M3 - Article. C2 - 23036845. VL - 39. SP - 754. EP - 759. JO - Burns. JF - Burns. SN - 0305-4179. IS - 4. ER - ...

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Flamazine cream contains the active ingredient silver sulfadiazine, which is an antibacterial used to treat and prevent infection of burns, leg ulcers, pressure sores and fingertip injuries - find out everything you need to know about using it

Log In to Order or. [6] It is available as a generic medication. Consult your doctor if you are breastfeeding. Top answers from doctors based on your search: Specializes in Internal Medicine and Pediatrics. We comply with the HONcode standard for trustworthy health information -, THERMAZENE (silver sulfadiazine cream;topical). It is is usually used for burns and they can cause scarring. No information currently available. During pregnancy, Bactroban Cream is unlikely to harm a fetus. Drug information found in the drug comparisons published on RxList.com is primarily sourced from the FDA drug information. During pregnancy, Silvadene Cream should be used only when prescribed. Multisource drug products listed under the same heading (i.e., identical active ingredients(s), dosage form, and route(s) of administration) and having the same strength (see Therapeutic Equivalence-Related Terms, Pharmaceutical Equivalents) generally will be coded AB if a study is submitted demonstrating bioequivalence. To ...

Silver sulfadiazine is an antibiotic intended for topical application to the skin and it acts as a bacteriostatic agent. This drug prevents the growth and reproduction of bacteria

Silvadene (Silver Sulfadiazine) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications including drug comparison and health resources.

Trade names include Silvadene, SSD AF, Thermazene. Silver Sulfadiazine topical cream is a sulfa drug that is used in the prevention or treatment of skin infections in patients with second and third degree burns; it can also be used for other conditions that will be determined by your doctor. Silvadene has - July 2, 2013

SSD AF (Silver sulfadiazine) drug information & product resources from MPR including dosage information, educational materials, & patient assistance.

A Comparative Study on the Efficacy of Chitosan Gel Formulation and Conventional Silver Sulfadiazine Treatment in Healing Burn Wound Injury at Molecular Level

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Toxoplasmic encephalitis is a major cause of illness and death in AIDS patients. Standard treatment for toxoplasmic encephalitis is to combine pyrimethamine and sulfadiazine. Continuous treatment is necessary to prevent recurrence of the disease, but constant use of pyrimethamine/sulfadiazine is associated with toxicity. Clindamycin has been shown to be effective in treatment of toxoplasmic encephalitis in animal studies. This study evaluates pyrimethamine as a preventive treatment against toxoplasmic encephalitis (per 3/26/91 amendment, clindamycin arm was discontinued).. Patients are randomized to receive pyrimethamine or placebo three times a week. All patients must be on aerosolized pentamidine, trimethoprim / sulfamethoxazole (T/S), or dapsone for Pneumocystis carinii pneumonia prophylaxis. Patients will be evaluated bi-weekly for the first month and every other month thereafter for at least 24 months. ...

Splits to produce bactericidal concentrations of silver and sulfadiazine. Action is at level of cell membrane and cell wall. Therapeutic Effects: Bactericidal action against organisms found in burns. Spectrum: Broad spectrum includes activity against many gram-negative and gram-positive bacteria, anaerobes, and some yeast. ...

The high doses of sulfadiazine (SDZ), used in synergistic combination with pyrimethamine, are mainly responsible for severe side effects and discontinuation of toxoplasmosis treatments. In the search for new strategies that improve the efficacy of treatments with reduced doses of SDZ, we have determined the performance of cationic G4 (DG4) and anionic G4.5 (DG4.5) poly(amidoamine) (PAMAM) dendrimers to act as SDZ nanocarriers. Both dendrimers could efficiently load SDZ (SDZ-DG4 and SDZ-DG4.5) up to a ratio of 30 molecules SDZ per dendrimer molecule. The MTT assay on Vero and J774 cells showed no cytotoxicity for DG4.5 and its SDZ complex incubated between 0.03 and 33 microM of dendrimer concentration. On the other hand, DG4 and its SDZ complex resulted cytotoxic when incubated at dendrimer concentrations higher than 3.3 microM. Finally, complexes and empty dendrimers were in vitro tested against Vero cells infected with RH strain of Toxoplasma gondii along 4h of treatment. For SDZ-DG4.5 and DG4.5 to

Silvadene stasis ulcers - Can you use silvadene (silver sulfadiazine) for stasis ulcers? It is used. Although silvadene (silver sulfadiazine) is used for venous ulcers, it is rarely ever necessary. Silvadene (silver sulfadiazine) actually increases the risk of infection if you dont change it and reapply it a few times a day. Antibiotic creams and ointments have been shown to have no effect on ulcer healing. The mainstay of treatment for venous ulcers is compression, walking, and treating the underlying reflux that is causing the ulcer.

Revision date indicates the date the MSDS or SDS was last revised. MSDS / SDS are dated when they are originally issued AND when any significant change has been made to the chemical compound or research has revealed a health or physical hazard different from what was originally stated. Additional information regarding MSDS / SDS is available at https://www.osha.gov ...

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If you have tried to treat this ailment, please complete the following form to help us better our data, and help guide people to the best possible treatments. CureCrowd is a public resource with absolutely no vested interest in the outcomes of our studies. ...

If you have tried to treat this ailment, please complete the following form to help us better our data, and help guide people to the best possible treatments. CureCrowd is a public resource with absolutely no vested interest in the outcomes of our studies. ...

سیلور سولفادیازین (آیوپاک آدی: Silver [(4-aminophenyl)sulfonyl](pyrimidin-2-yl)azanide, اینگیلیسجه: Silver sulfadiazine, (چینجه:磺胺嘧啶银‎)) بیر شیمیایی بیلشیک دواء. بۇ دواءنین مول جرمیسی مول/قرم ۳۵۷٫۱۴ دیر. سیلور سولفادیازین آنتی‌بیوتیک‌ اۆچون ایستیفاده اوْلونور. ...

Bacteria synthesiza their Folic acid via Para-amino benzoic acid (PABA). Sulphadiazine competitively inhibits PABA in the Folic acid metabolic cycle while Trimethoprim prevents reduction of Dihydrofolic acid to Tetrahydrofolic acid in the bacterial cells. This sequential blockade inhibits bacterial cell multiplication.. The combination of Sulphadiazine and Trimethoprim at the ratio of 5:1 potentiates each others action. Even though both drugs are bacteriostatic individually, the combination makes them a potent bactericidal.. ...

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Background: Heparin is a multifaceted compound with uses not only as an anticoagulant, but also as an anti-inflammatory, anti-allergenic, anti-histaminic, anti-serotonin, anti-proteolytic and neoangiogenic agent. The aim of the study was to study the effect of topical heparin in the management of burns in terms of morbidity, mortality & safety.Subjects and Methods:A hospital based RCT with total duration of 16 months from June, 2018 to September, 2019 with 100 patients (age between 15-45 years, burns from 20-60%, with less than 48 hours duration), randomly enrolled into 2 groups, after initial resuscitative measures, 50 cases receiving Topical Heparin treatment, 50 controls receiving conventional treatment (1% silver sulphadiazine) with i.v. antibiotics, after explaining the study objectives and taking informed written consent. Data analysis was performed using Epi Info software.Results:Patients treated with topical heparin experienced statistically significant (p,0.05) improved pain relief, ...

Silver sulfadiazine can be prescribed by Independent supplementary prescribers but is not available within the community practitioners formulary and is only to be used for two weeks ...

So what happened to Allies burn? When we left the cemetery, we went to the drugstore and bought silver sulfadiazine. Its an antibiotic, and because she had blisters, my doctor friend suggested to apply it thickly twice a day, after washing, and cover her burn with sterilized gauze. After about a week, her skin is completely healed. Now, I just apply some moisturizer and prevent sunburn on her arm to lessen the discoloration. A dermatologist told me it will take about six months for it to become less noticeable. But really, I barely notice it on her arm now ...

So what happened to Allies burn? When we left the cemetery, we went to the drugstore and bought silver sulfadiazine. Its an antibiotic, and because she had blisters, my doctor friend suggested to apply it thickly twice a day, after washing, and cover her burn with sterilized gauze. After about a week, her skin is completely healed. Now, I just apply some moisturizer and prevent sunburn on her arm to lessen the discoloration. A dermatologist told me it will take about six months for it to become less noticeable. But really, I barely notice it on her arm now ...

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Bebber, M. R. (2017). Tempered strength: A controlled experiment assessing opportunity costs of adding temper to clay. Journal of Archaeological Science, 86, 1-13. doi: http://dx.doi.org/10.1016/j.jas.2017.08.002.. de Ávila, C., Chometton, S., Lenglos, C., Calvez, J., Gundlach, A. L., & Timofeeva, E. (2017). Differential effects of relaxin-3 and a selective relaxin-3 receptor agonist on food and water intake and hypothalamic neuronal activity in rats. Behavioural Brain Research. doi: http://dx.doi.org/10.1016/j.bbr.2017.08.044.. El-Feky, G. S., El-Banna, S. T., El-Bahy, G. S., Abdelrazek, E. M., & Kamal, M. (2017). Alginate coated chitosan nanogel for the controlled topical delivery of Silver sulfadiazine. Carbohydrate Polymers. doi: http://dx.doi.org/10.1016/j.carbpol.2017.08.104.. Chikama, K., Yamada, H., Tsukamoto, T., Kajitani, K., Nakabeppu, Y., & Uchimura, N. (2017). Chronic atypical antipsychotics, but not haloperidol, increase neurogenesis in the hippocampus of adult mouse. Brain ...

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ABSTRACT: BACKGROUND: Worldwide, approximately two billion people are chronically infected with Toxoplasma gondii with largely unknown consequences. METHODS: To better understand long-term effects and pathogenesis of this common, persistent brain infection, mice were infected at a time in human years equivalent to early to mid adulthood and studied 5-12 months later. Appearance, behavior, neurologic function and brain MRIs were studied. Additional analyses of pathogenesis included: correlation of brain weight and neurologic findings; histopathology focusing on brain regions; full genome microarrays; immunohistochemistry characterizing inflammatory cells; determination of presence of tachyzoites and bradyzoites; electron microscopy; and study of markers of inflammation in serum. Histopathology in genetically resistant mice and cytokine and NRAMP knockout mice, effects of inoculation of isolated parasites, and treatment with sulfadiazine or alphaPD1 ligand were studied. RESULTS: Twelve months ...

Antimicrobial agents are used extensively off‐label in mink, as almost no agents are registered for this animal species. Pharmacokinetic (PK) and pharmacodynamic (PD) data are required to determine antimicrobial dosages specifically targeting mink bacterial pathogens. The aims of this study were to assess, in a PKPD framework, the empirical dosage regimen for a combination of trimethoprim (TMP) and sulfadiazine (SDZ) in mink, and secondarily to produce data for future setting of clinical breakpoints. TMP and SDZ PK parameters were obtained experimentally in 22 minks following IV or oral administration of TMP/SDZ (30 mg/kg, i.e. 5 mg/kg TMP and 25 mg/kg SDZ). fAUC/MIC with a target value of 24 hr was selected as the PKPD index predictive of TMP/SDZ efficacy. Using a modeling approach, PKPD cutoffs for TMP and SDZ were determined as 0.062 and 16 mg/L, respectively. By incorporating an anticipated potentiation effect of SDZ on TMP against Escherichia coli and Staphylococcus delphini, the PKPD ...

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The proteinase activity of strains of group A streptococci isolated from patients in acute and convalescent phases of illness was found to be remarkably constant. Sulfadiazine therapy of patients did not affect proteinase production by the infecting streptococci.. The ability to produce streptococcal proteinase would appear to be related to the strain and not necessarily to the serological type.. No relationship could be found between the capacity of group A streptococci of different serological types to produce proteinase and the various clinical responses to infection with these microorganisms.. ...

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Drug Notes Drugs new & old in the limelight last week: | Sulfamerazine hit the market last fortnight. Its champions claim: 1) sulfamerazine is just as effective as sulfadiazine for pneumonia;...

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