We present data demonstrating the gene expression of substance P and its receptor in human peripheral blood-isolated monocytes and macrophages. Using the RT-PCR assay, preprotachykinin-A (substance P) mRNA is detected in human peripheral blood-isolated monocytes and macrophages. Among the alpha, beta, and gamma transcripts of the substance P gene, only the beta and gamma transcripts are detectable in these cells. By Southern blot assay these RT-PCR-amplified transcripts are recognized using a specific substance P probe. Sequence analysis of the RT-PCR products from both monocytes and macrophages also confirmed the structure of these transcripts, which are identical to those found in human neuronal cells. At the protein level, both human monocytes and macrophages produced endogenous substance P as determined by an enzyme immunoassay. Capsaicin, a vanillyl fatty acid amide (ingredient of hot pepper), released substance P from both human monocytes and macrophages. In addition, using nested RT-PCR ...
The centrally induced effects of angiotensin II and substance P on the cardiovascular system and on neuronal efferent activity of the splanchnic, renal, and adrenal nerves were investigated in chronically instrumented conscious rats. The pressor responses to substance P injected into the lateral brain ventricle were accompanied by marked and short latency increases in heart rate, cardiac output, splanchnic, renal, and adrenal nerve activity, and a rise in plasma noradrenaline and adrenaline. Behaviorally, an arousal-type reaction was observed. In contrast, the pressor responses to intracerebroventricular angiotensin II were associated with initial decreases in heart rate, cardiac output, splanchnic, renal, and adrenal nerve activity, and a fall in plasma noradrenaline at the time of the maximal blood pressure increase. In some but not all animals, a second blood pressure peak associated with increases in heart rate and splanchnic nerve activity was observed after several minutes. Incomplete ...
This study tested the hypothesis that DPP4 inhibition potentiates the vascular effects of substance P during ACE inhibition. We found no effect of combined DPP4 and ACE inhibition on substance P-mediated vasodilation; however, during concurrent DPP4 and ACE inhibition, intra-arterial administration of substance P stimulated the sympathetic nervous system. In addition, DPP4 inhibition diminished substance P-induced tPA release in women.. This study extends the findings of 3 previous studies examining the interactive effect of ACE inhibition and DPP4 inhibition on blood pressure. Marney et al14 reported that the DPP4 inhibitor sitagliptin reduced blood pressure in subjects with the metabolic syndrome when given alone for 5 days. When given in combination with an ACE inhibitor, however, sitagliptin attenuated the hypotensive response to ACE inhibition and caused an increase in heart rate and circulating norepinephrine concentrations.14 Boschmann et al15 reported a significant increase in ...
The invention relates to a therapeutic composition for topical application containing at least one product with an irritant side effect and a substance P antagonist for reducing or even eliminating the irritant effect of this product. It also relates to the use of a substance P antagonist for the preparation of a pharmaceutical composition for topical application containing at least one product with an irritant side effect for reducing or even eliminating the irritant effect of this product. The substance P antagonist may be a peptide compound or a nitrogen-containing compound or a nitrogen-, sulphur- or oxygen-containing heterocyclic compound.
It has been proposed that substance P and calcitonin gene-related peptide (CGRP) are upregulated in low-threshold myelinated primary afferents after certain types of nerve injury, and that release of substance P from these afferents contributes to the resulting tactile allodynia. To test this hypothesis, we looked for neuropeptides in Aβ primary afferent terminals in the ipsilateral gracile nucleus and spinal dorsal horn in three nerve injury models: sciatic nerve transection (SNT), spinal nerve ligation (SNL), and chronic constriction injury (CCI). We also looked for evidence of neurokinin 1 (NK1) receptor internalization in the dorsal horn after electrical stimulation of Aβ afferents. We found no evidence of either substance P or CGRP expression in injured Aβ terminals in the spinal cord in any of the models. Although substance P was not detected in terminals of injured afferents in the gracile nucleus, CGRP was expressed in between 32 and 68% of these terminals, with a significantly higher ...
It has been proposed that substance P and calcitonin gene-related peptide (CGRP) are up-regulated in low-threshold myelinated primary afferents following certain types of nerve injury, and that release of substance P from these afferents contributes to the resulting tactile allodynia. To test this hypothesis, we looked for neuropeptides in Aβ primary afferent terminals in the ipsilateral gracile nucleus and spinal dorsal horn in three nerve injury models: sciatic nerve transection (SNT), spinal nerve ligation (SNL) and chronic constriction injury (CCI). We also looked for evidence of neurokinin 1 (NK1) receptor internalisation in the dorsal horn following electrical stimulation of Aβ afferents. We found no evidence of either substance P or CGRP expression in injured Aβ terminals in the spinal cord in any of the models. Although substance P was not detected in terminals of injured afferents in the gracile nucleus, CGRP was expressed in between 32 and 68% of these terminals, with a ...
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RATIONALE: Diagnostic procedures, such as positron emission tomography (PET) using [18F]-labeled substance P antagonist receptor quantifier, may be effe
Central or peripheral administration of substance P (SP) produces a number of effects on behavior. In mice, SP decreases isolation-induced aggressive [1] and nociceptive [2] behaviors. SP alters...
1. The presence of immunoreactive substance P (I-SP) in the vagus nerve of 5 species was demonstrated by radioimmunoassay. Different amounts of SP per unit weight were found: Guinea pig > cat >...
Blog on Substance P [Delta-Aminovaleryl6, Pro9, N-Me-Leu10] peptide product: The Substance P [Delta-Aminovaleryl6, Pro9, N-Me-Leu10] n/a (Catalog #MBS658288) is a Peptide produced fr...
The "P" in substance "P" [SP] is mistakenly thought to signify Pain or Psychiatric substance. Substance P ("P" standing for "Preparation" or "Powder") is a neuropeptide - but only nominally so, as it is ubiquitous. Its receptor - the neurokinin type 1 - is distributed over cytoplasmic and nuclear membranes of many cell types (neurons, glia, endothelia of capillaries and lymphatics, fibroblasts, stem cells, white blood cells) in many tissues and organs. SP amplifies or excites most cellular processes.[15][16]. Substance P is a key first responder to most noxious/extreme stimuli (stressors), i.e., those with a potential to compromise biological integrity. SP is thus regarded as an immediate defense, stress, repair, survival system. The molecule, which is rapidly inactivated (or at times further activated by peptidases) is rapidly released - repetitively and chronically, as warranted, in the presence of a stressor. Unique among biological processes, SP release (and expression of its NK1 Receptor ...
New research from the University of Adelaide has shown for the first time that the growth of brain tumours can be halted by a drug currently being used to help patients recover from the side effects of chemotherapy.. The discovery has been made during a study looking at the relationship between brain tumours and a peptide associated with inflammation in the brain, called "substance P".. Substance P is commonly released throughout the body by the nervous system, and contributes to tissue swelling following injury. In the brain, levels of substance P greatly increase after traumatic brain injury and stroke.. "Researchers have known for some time that levels of substance P are also greatly increased in different tumour types around the body," says Dr Elizabeth Harford-Wright, a postdoctoral fellow in the Universitys Adelaide Centre for Neuroscience Research.. "We wanted to know if these elevated levels of the peptide were also present in brain tumour cells, and if so, whether or not they were ...
TY - JOUR. T1 - Substance P regulates Th1-type colitis in IL-10 knockout mice. AU - Weinstock, Joel V.. AU - Blum, Arthur. AU - Metwali, Ahmed. AU - Elliott, David. AU - Bunnett, Nigel. AU - Arsenescu, Razvan. PY - 2003/10/1. Y1 - 2003/10/1. N2 - Substance P (SP) is a proinflammatory molecule that interacts with a neurokinin 1 receptor (NK-1R), which is on T cells and helps control IFN-γ production. IL-10 -/- mice given a nonsteroidal anti-inflammatory drug (NSAID) develop Th1 colitis. We studied the importance of SP and NK-1R in this colitis model. LP T cells were isolated to study their NK-1R expression. LP T cells from IL-10 -/- mice expressed NK-1R and produced IFN-γ only after NSAID treatment and induction of colitis. LP T cells from NSAID-treated wild-type controls or from age-matched untreated IL-10 -/- animals did not express NK-1R or produce IFN-γ. Experiments showed that IL-12 induced NK-1R transcription in CD4 + T cells cultured in vitro. However, T cells cultured with IL-12 and ...
Ma W, Ribeiro-da-Silva A, De Koninck Y, Radhakrishnan V, Henry JL, Cuello AC. 1996. Quantitative analysis of substance P-immunoreactive boutons on physiologically characterized dorsal horn neurons in the cat lumbar spinal cord.. J Comp Neurol. 376(1):45-64. ...
Vascular endothelial cells respond to certain vasoactive agents by releasing factors which act on medial smooth muscle to cause relaxation or contraction of blood vessels. One of the substances responsible for endothelium-dependent relaxation to acetylcholine has recently been identified as nitric oxide. We have tested the hypothesis that the ability of vascular endothelium to cause relaxation in response to stimulation by vasoactive agents is related in some way to the pattern of perivascular innervation. The actions of acetylcholine and substance P were tested in the presence of methoxamine induced tone in the isolated perfused mesenteric arterial bed of the rat. Tissues were tested from untreated normal 12 week old Sprague-Dawley rats and from rats which had been treated from birth with capsaicin to prevent the development of peptidergic perivascular innervation or 6-hydroxydopamine to prevent development of catecholaminergic innervation. Concentration dependent endothelium-dependent ...
en] A radioimmunoassay of the undecapeptide substance P (SP) and its application in rabbit lung superfusate has been developed. The assay was based on the use of a radioactive tracer, 125I-SP-Tyr8, which showed, with an excess of antibodies, a specific binding greater than 90% and a nonspecific binding lower than 2%. This tracer was stable for 4 weeks at -20 degrees C. Its specific radioactivity was 384 Ci/mmol. The assays lower limit of detection was 10 pg/ml (0.7 fmol). The determination of SP in rabbit lung perfusate required extraction and concentration using octadecylsilane cartridges. Under these conditions, the recovery of SP from experiments on lung perfusates (n=4) was 75.0+/-4.5%, and the intraassay and interassay coefficients of variation were 7.3+/-1.9% and 10.7+/-1.3%, respectively. Amounts of SP released in rabbit lung perfusates were determined following stimulation of pulmonary C fibers with capsaicin (10(-4) M). During the stimulation period, the values of SP from lung ...
. After my post on the exciting research published in Great Britain on Botox Chimeras earlier today, Dr. Robert Caudle graciously notified me of his teams recent research publication on Botox conjugates injected into the cerebral spinal fluid cisterns in mice. The abstract is below: . Anti-nociceptive effect of a conjugate of substance P and…
Several categories of drugs are identical to or derived from biological products. Some hormones given as drugs, for example, require special mention because the drug name differs from the name used for the endogenous substance (please note that this is not a comprehensive list of such drugs). Other categories of biologicals are derived from specific guidelines developed by USAN, outlined below. Using the appropriate name can help clarify that the substance referred to is a drug, although for less familiar drug names it may be necessary to include the endogenous hormone name in parentheses to clarify the action of the Less ...
Disclosed is a device and method of use for detecting polyvalent analytes such as antibody to the AIDS virus, utilizing an inverse sandwich method. The test device comprises a first substance having an epitope, bound to a label and capable of moving within the test device. The test device further comprises a second substance immobilized to the test device and spatially separated from the first substance. The second substance has an epitope substantially similar to the epitope of the first substance. Upon application to the test device, the polyvalent analyte binds to the first substance and moves within the test device to the location of the second substance with both polyvalent analyte and first substance are immobilized at location of the second substance. Polyvalent analyte is detected by the presence of the label at the location of the second substance. Also disclosed is a control substance for use with the device that can be used to determine completion of the test and viability of the device.
De Koninck Y, Ribeiro-da-Silva A, Henry JL, Cuello AC. 1992. Spinal neurons exhibiting a specific nociceptive response receive abundant substance P-containing synaptic contacts.. Proc Natl Acad Sci U S A. 89(11):5073-7. ...
De Koninck Y, Ribeiro-da-Silva A, Henry JL, Cuello AC. Spinal neurons exhibiting a specific nociceptive response receive abundant substance P-containing synaptic contacts. Proc Natl Acad Sci USA. 1992;89(11):5073-7. ...
NPs can expect to encounter clients requiring prescriptions for controlled substances, since many medications are controlled substances. You should plan for this anticipated client care need by establishing strategies consistent with College standards and guidelines. You should also work with your employer to ensure you have access to resources for meeting client needs. In this case, the resource you need is the ability to refer to a health professional such as an NP or physician authorized to prescribe controlled substances. The clients prescription must be filled out by the authorized prescriber in a manner that is consistent with their regulatory obligations. NPs who are not authorized to prescribe controlled substances must not taper a controlled substance or renew a prescription for a controlled substance as these are considered prescribing.. If you commonly encounter clients in your practice that require controlled substances you should consider completing the education requirement that ...
The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex assemblies. As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
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The original scripts I wrote were to save time and facilitate an eDirectory upgrade. The scripts have evolved into simple, basic, time saving proactive management scripts. I wanted to share the scripts with the Cool Solutions readers (with the usual disclaimers of use at your own risk). Ive since updated the scripts, revisited and retouched them for different needs, but here is the latest that ive been using. I use the %if variable command now on NetWare 6 and Ive removed all Wait for text commands that were reading the system console for text strings, and replaced them with pauses. The NetWare 6 Logger Screen changed where the output was going, and rather than get fancy I just went with the pause.. AT a minimum, youll need STUFFKEY.NLM and TOOLBOX.NLM. I also use DELAYCMD.NLM and theyre all ideally scheduled with CRON (Ive included 3 example CRONTAB files). Ive included an old version of TOOLBOX.NLM I used to use in case youre not patched to the latest and greatest SP levels on all ...
The original scripts I wrote were to save time and facilitate an eDirectory upgrade. The scripts have evolved into simple, basic, time saving proactive management scripts. I wanted to share the scripts with the Cool Solutions readers (with the usual disclaimers of use at your own risk). Ive since updated the scripts, revisited and retouched them for different needs, but here is the latest that ive been using. I use the %if variable command now on NetWare 6 and Ive removed all Wait for text commands that were reading the system console for text strings, and replaced them with pauses. The NetWare 6 Logger Screen changed where the output was going, and rather than get fancy I just went with the pause.. AT a minimum, youll need STUFFKEY.NLM and TOOLBOX.NLM. I also use DELAYCMD.NLM and theyre all ideally scheduled with CRON (Ive included 3 example CRONTAB files). Ive included an old version of TOOLBOX.NLM I used to use in case youre not patched to the latest and greatest SP levels on all ...
In adult animals treated as neonates with the sympathetic neurotoxin 6-hydroxydopamine, a virtual absence of TH-IR and NPY-IR fibers was observed, whereas the distribution of CGRP-IR and SP-IR fibers appeared unaltered ...
The inability of CP-96,345 to inhibit caudally directed biting and scratching produced in mice by a single i.t. injection of SP presents an interesting paradox concerning the identity of receptors with which this compound interacts to elicit its effects in vivo. This is especially true as the doses of CP-96,345 tested readily inhibited other effects, including NMDA activity, desensitization to the behavioral effects of SP and sensitization to KA. If SP-induced behaviors are exclusively the result of NK-1 activation, CP-96,345 and CP-99,994 would be expected to inhibit the response to SP as they are potent inhibitors of [3H]SP binding (Snider et al., 1991). Our data suggest that either the response to a single injection of SP is not mediated by activation of NK-1 sites, or that CP-96,345 and CP-99,994 also bind, with an even greater affinity, to a site distinct from the NK-1 receptor to affect EAA activity.. Although it is possible that SP induces a behavioral response in mice that is not ...
Teatrul SubPământ. Valea Jiului după 1989 este un proiect de observație cotidiană și analiză critică a existenței unor comunități afectate decisiv de schimbarea politică din anii 90. Proiectul își propune să documenteze situația economică, viața și munca minerilor în post-socialism. Teatrul SubPământ este un proiect de reconstrucție performativă a poveștilor-document care fundamentează istoria comunităților din Valea Jiului, aflate la limita dintre supraviețuire, migrație, dispariție și posibilă reconstrucție.. Spectacolul Sub Pământ are la bază o cercetare în Valea Jiului, coordonată de Mihaela Michailov (dramaturg), Vlad Petri (fotograf), David Schwartz (regizor). Cercetarea a avut mai multe direcţii - ateliere, discuţii libere şi interviuri cu mineri, soții de miner, pensionari, paznici de mină, lideri de sindicat, oameni care trăiesc din furtul de cărbune, copii.. Sub Pământ este un spectacol-arhivă de povești-mărturii ale unor comunități ...
The table below is the Annex XVII to REACH and includes all the restrictions adopted in the framework of REACH and the previous legislation, Directive 76/769/EEC. Each entry shows a substance or a group of substances or a substance in a mixture, and the consequent restriction conditions. The latest consolidated version of REACH presents the restrictions adopted until the date of publication. Subsequent changes are included in the amending Commission regulations.. ...
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The table below is the Annex XVII to REACH and includes all the restrictions adopted in the framework of REACH and the previous legislation, Directive 76/769/EEC. Each entry shows a substance or a group of substances or a substance in a mixture, and the consequent restriction conditions. The latest consolidated version of REACH presents the restrictions adopted until the date of publication. Subsequent changes are included in the amending Commission regulations.. ...
Here you can find all of the regulations and regulatory lists in which this substance appears, according to the data available to ECHA. This substance has been found in the following regulatory activities (directly, or inheriting the regulatory context of a parent substance):. ...
Here you can find all of the regulations and regulatory lists in which this substance appears, according to the data available to ECHA. This substance has been found in the following regulatory activities (directly, or inheriting the regulatory context of a parent substance):. ...
Water, sugar and table salt are common examples of neutral substances. The pH scale rates substances based on how acidic or basic they are. A substance that is not acidic or basic is described as a...
Again in this section you will find articles that pertain to substance abuse. Information on the substances are manufactured and distributed. Along with important information pertaining to how these substances can destroy ones body and ruin their life
Here you can find all of the regulations and regulatory lists in which this substance appears, according to the data available to ECHA. This substance has been found in the following regulatory activities (directly, or inheriting the regulatory context of a parent substance):. ...
Here you can find all of the regulations and regulatory lists in which this substance appears, according to the data available to ECHA. This substance has been found in the following regulatory activities (directly, or inheriting the regulatory context of a parent substance):. ...
By default, all articles on GreenMedInfo.com are sorted based on the content type which best reflects the data which most users are searching for. For instance, people viewing substances are generally most interested in viewing diseases that these substances have shown to have positive influences. This section is for allowing more advanced sorting methods. Currently, these advanced sorting methods are available for members only. If you are already a member, you can sign in by clicking here. If you do not currently have a user account, and would like to create one/become a member, click here to begin the singup process ...
What is the difference between Pure Substance and Mixture? A pure substance contains only one kind of compound.Mixtures are composed of several kinds of ..
In a chemical reaction, substance A combines with substance B to form subtance Y. At the start of the reaction, the quantity of A present is a grams, and the quantity of B present is b grams. Assume a is less than b. At time t seconds ...
View Notes - Ch. 16 from HLTH 2101 at UNC Charlotte. Ch. 16 Using Drugs Responsibly For thousands of years people have been ingesting substances to heal themselves. Today, some healing substances are
Criterion 5(a)(i) of Decision 2014/312/EU provides a list of groups of substances which are explicitly indicated as a subject of the assessment and verification of criterion 5(a). However, it was proven that this list of substances is not complete and an additional group of substances needs to be added, namely 8. Substances in binders and polymer dispersions 8a. Binders and cross linking agents, 8b. Reaction products and residues. Moreover, for reasons of clarity, the list of groups of substances should be moved to the assessment and verification text of the criterion since that list is used for the assessment and verification.. ...
Analysing substances is an important part of GCSE chemistry. There are various methods we use to do this and you will be familiar with some from your classes. Can you remember them and what they involve? If not, dont worry! To help you revise weve created this quiz for Year 10 and Year 11 students
is the mechanism of substances to induce the same ultimate effects in the body as other substances, as if they were receptor agonists or antagonists, but without binding to the same receptor.ExamplesPhysiological agonists*Adrenaline induces…