EXECUTIVE SUMMARY Stroke Types and Incidence Endovascular Stroke Management Techniques and Tools Procedures and Markets. Procedures and Markets by Geography Suppliers Summary Exhibit 1: Global Incidence of Stroke by Major Type, 2013-2019 Summary Exhibit 2: Global Endovascular Interventions for Acute Stroke Management by Major Type, 2013-2019 Summary Exhibit 3 Global Market for Acute Stroke Therapy Products by Major Type, 2013-2019 Summary Exhibit 4: Endovascular Interventions for Acute Stroke Management by Major Geography, 2013-2019. Summary Exhibit 5: Global Endovascular Acute Stroke Therapies Market by Major Geography, 2013-2019. Summary Exhibit 6: Global Endovascular Acute Stroke TherapiesMarket, Estimated Supplier Shares, 2014 1.0 ETIOLOGY & EPIDEMIOLOGY OF ACUTE STROKE. 1.1 Overview of the Brain. 1.1.1 Cerebral Arterial Blood Supply 1.1.2 Sites of Plaque and Emboli Formation 1.2 Etiology of Stroke 1.2.1 Ischemic Stroke. 1.2.1.1 Major Types. 1.2.1.1.1 Thrombotic Stroke 1.2.1.1.2 Embolic ...
Latest industry research report on Acute Ischemic Stroke Diagnosis and Treatment Market. Ischemic stroke is caused by a dysfunction in the supply of blood to the brain due to emboli, thrombus or atherosclerosis occurring in cerebral arteries. According to a World Health Organization (WHO) estimate, around 17 million people die every year due to cardiovascular diseases.. Heart attacks and strokes respectively account for the highest number of deaths due to cardiovascular diseases, globally. The statistics of the Centres for Disease Control and Prevention suggest that about 87% of all strokes are ischemic strokes. Stroke is one of the leading causes of long term disability, occurring at a higher rate in the old age population.. Get Free Sample Report Of Acute Ischemic Stroke Diagnosis and Treatment Market @ http://www.marketresearchstore.com/report/world-acute-ischemic-stroke-diagnosis-and-treatment-market-71669#RequestSample. Moreover, stroke leads to 1 out of every 20 deaths, costing around $34 ...
In this study, a newly developed risk assessment model for stroke onset was shown by several statistical indicators to be superior to the gold-standard Framingham Stroke Risk Score. This new stroke risk score model(NEW-STROKE) was developed using a novel, model-building technology, called synthesis analysis, that allowed for the incorporation of seven additional literature-derived risk factors into the original FSRS.. Compared with the discrimination of these two models, the NEW-STROKE model had higher modified C-statistics than the original FSRS model in the overall group and in the female subgroup in the presence of censoring for survival time. This observation illustrates that the NEW-STROKE model has higher precision in both the overall group and the female subgroup in predicting stroke risk score. When evaluating calibration, the NEW-STROKE model outperformed the original FSRS model as evidenced by smaller Hosmer-Lemeshow chi-square values (,20) after recalibration in the overall group and ...
To the Editor:. Although there have been major advances in stroke diagnosis, prevention, and treatment during the past decade, stroke is the still third most common cause of death in Taiwan.1 The intravenous tissue plasminogen activator (tPA) is currently the only approval medical therapy for acute ischemic stroke within a 3-hour window2,3 and is recommended by Taiwan Stroke Societys Guidelines for the Management of Acute Ischemic Stroke.4 In the Taiwan Thrombolytic Therapy for Acute Ischemic Stroke Study5 and thrombolysis with alteplase for acute ischemic stroke in the Safe Implementation of Thrombolysis in Stroke-Monitoring Study6 both showed that intravenous tPA is safe and effective in routine clinical use for acute ischemic stroke within 3 hours. However, in Taiwan Thrombolytic Therapy for Acute Ischemic Stroke Study, only 241 patients had received tPA treatment in 32 months of observation.5 A survey of stroke center status in Taiwan showed that ,1% of ischemic stroke patients received ...
There have been relatively few community-based studies of long-term prognosis after acute stroke. This study aimed to provide precise estimates of the absolute and relative risks of dying in an unselected cohort of patients with a first-ever stroke.. Six hundred seventy-five patients were registered by a community-based stroke register (the Oxfordshire Community Stroke Project) and prospectively followed up for up to 6.5 years. Their relative risk of death was calculated using age- and sex-specific mortality rates for Oxfordshire.. During the first 30 days, 129 (19%) patients died. Patients who survived at least 30 days after a first-ever stroke thereafter had an average annual risk of death of 9.1%, 2.3-fold the risk in people from the general population. Although the absolute (about 15%) and relative (about threefold) risks of death were highest in these 30-day survivors over the first year after the stroke, they were at increased risk of dying over the next few years (range of relative risk ...
In 2008, the recently founded European Stroke Organisation published its guidelines for the management of ischemic stroke and transient ischemic attack. This highly cited document was translated in several languages and was updated in 2009. Since then, the European Stroke Organisation has published guidelines for the management of intracranial aneurysms and subarachnoidal hemorrhage, for the establishment of stroke units and stroke centers, and recently for the management of intracerebral hemorrhage. In recent years, the methodology for the development of guidelines has evolved significantly. To keep pace with this progress and driven by the strong determination of the European Stroke Organisation to further promote stroke management, education, and research, the European Stroke Organisation decided to delineate a detailed standard operating procedure for its guidelines. There are two important cornerstones in this standard operating procedure: The first is the implementation of the Grading of
TY - JOUR. T1 - Stroke outcome in clinical trial patients deriving from different countries. AU - Ali, Myzoon. AU - Atula, Sari. AU - Bath, Philip M W. AU - Grotta, James. AU - Hacke, Werner. AU - Lyden, Patrick. AU - Marler, John R.. AU - Sacco, Ralph L. AU - Lees, Kennedy R.. PY - 2009/1/1. Y1 - 2009/1/1. N2 - BACKGROUND AND PURPOSE: Stroke incidence and outcome vary widely within and across geographical locations. We examined whether differences in index stroke severity, stroke risk factors, mortality, and stroke outcome across geographical locations remain after adjusting for case mix. METHODS: We analyzed 3284 patients from the Virtual International Stroke Trials Archive (VISTA). We used logistic regression to examine the incidence of mild index stroke, functional, and neurological outcomes after accounting for age, medical history, year of trial recruitment, and initial stroke severity in the functional and neurological outcome analyses. We examined mortality between geographical regions ...
At least half of childhood stroke survivors suffer long-term impairments. Rapid identification of stroke is essential to minimize the extent of injury by restoring perfusion to viable brain. Improving diagnosis of childhood stroke requires correct identification of stroke by prehospital and emergency physicians, rapid performance of appropriate neuroimaging to confirm infarction, and targeted investigations to determine underlying causes, which guide treatment decisions to reduce recurrence risk. Areas covered: This review will summarize the barriers to rapid stroke diagnosis in pre-hospital and emergency department settings, describe recent progress in understanding of the spectrum, presenting clinical features and differential diagnosis of childhood stroke, discuss clinical stroke recognition tools which improve diagnostic accuracy, and their application to children ...
TY - JOUR. T1 - Routine Troponin Measurements Are Unnecessary to Exclude Asymptomatic Coronary Events in Acute Ischemic Stroke Patients. AU - Ali, Farwa. AU - Young, Jimmy. AU - Rabinstein, Alejandro. AU - Flemming, Kelly. AU - Fugate, Jennifer E.. PY - 2016/5/1. Y1 - 2016/5/1. N2 - Background Obtaining serum troponin levels in every patient with acute stroke is recommended in recent stroke guidelines, but there is no evidence that these contribute positively to clinical care. We sought to determine the clinical significance of measuring troponin levels in acute ischemic stroke patients. Methods We reviewed 398 consecutive patients with acute ischemic stroke at a large academic institution from 2010 to 2012. Troponin levels were measured as a result of protocol in place during part of the study period. The mean age was 70 years (standard deviation ±16 years) and 197 (49.5%) were men. Results Chronic kidney disease was present in 78 (19.6%), coronary artery disease in 107 (26.9%), and atrial ...
Estimated 10-Year Stroke Risk by Region and Race in the United States Mary Cushman, MD, MSc,1 Ronald A. Cantrell, PhD,2 Leslie A. McClure, PhD,3 George Howard, DrPH,3 Ronald J. Prineas, MD, PhD,4 Claudia S. Moy, PhD,5 Ella M. Temple, PhD,3 and Virginia J. Howard, PhD2 Objective: Black individuals younger than 75 years have more than twice the risk for stroke death than whites in the United States. Regardless of race, stroke death is approximately 50% greater in the "stroke belt" and "stroke buckle" states of the Southeastern United States. We assessed geographic and racial differences in estimated 10-year stroke risk. Methods: The Reasons for Geographic and Racial Differences in Stroke study is a population-based cohort of men and women 45 years or older, recruited February 2003 to September 2007 at this report, with oversampling of stroke belt/buckle residents and blacks. Racial and regional differences in the Framingham Stroke Risk Score were studied in 23,940 participants without previous ...
The rapid diagnosis and treatment of acute ischemic stroke are critical in the reduction of morbidity, disability and stroke associated mortality Under-education about stroke may prevent people from recognizing symptoms early enough to seek immediate care.. The studies reported on stroke patients managed in stroke center have shown that 39-42% of patients could not name any symptoms of stroke and 36% to 43% no risk factor of stroke.. The stroke patients are therefore a population at high risk for neurological events and cardiac vascular recurrence. However, no studies have evaluated the interest of the development of therapeutic workshops in stroke unit to educate patients about symptoms suggestive of stroke, risk factors and what to do in cases of stroke.. Investigators assume that the setting up of a therapeutic education workshop in the stroke unit may allow a better understanding of the symptoms, risk factors and what to do following stroke. So there is a direct benefit to the patient ...
article{3f0ddea8-dd33-4fdd-a777-97a29bef9f47, abstract = {Stroke outcome is determined by a complex interplay, where age and stroke severity are predominant predictors. Studies on hemorrhagic stroke indicate that APOE genotype is a predictor of poststroke outcomes,1,2 but results from studies on ischemic stroke are more conflicting.1,3 There is 1 study suggesting an influence of APOE genotype on age at ischemic stroke onset,4 and sex-specific effects on outcome have been reported.5 Taken together, there is a need for larger studies on APOE and ischemic stroke outcomes with integrated information on age, severity, and sex.,br/,,br/,The 3 common APOE alleles ε2, ε3, and ε4 can be separated by a combination of 2 single nucleotide polymorphisms (SNPs), rs429358 and rs7412. Thus, associations with APOE alleles are not directly captured in a regular genome-wide association study (GWAS), where each SNP is investigated separately. We derived the 3 common APOE alleles and investigated the interplay ...
Background: Given the limited time window available for treatment with tPA in acute ischemic stroke patients, guidelines recommend door-to-imaging time within 25 minutes of hospital arrival and a door-to-needle time (DTN) within 60 minutes. Despite temporal improvements in door-to-image and DTN, tPA treatment times remain suboptimal.. Objectives: To examine the contributions of door-to-image and imaging-to-needle times to delays in timely delivery of tPA to ischemic stroke patients, and to examine between-hospital variation in DTN.. Methods: A cohort analysis of 1,193 ischemic stroke patients treated with intravenous tPA from 2009-2012 at 25 Michigan hospitals participating in the Paul Coverdell National Acute Stroke Registry. The primary outcome was DTN (time in minutes from emergency department arrival to tPA delivery). Multi-level linear regression models included hospital-specific random effects.. Results: Mean patient age was 68 years, median NIHSS score was 11 (IQR 6-17), 51% were female, ...
OBJECTIVE: To investigate the influence of prestroke physical activity (PA) on acute stroke severity.. METHODS: Data from patients with first stroke were retrieved from registries with a cross-sectional design. The variables were PA, age, sex, smoking, diabetes, hypertension and statin treatment, stroke severity, myocardial infarction, new stroke during hospital stay, and duration of inpatient care at stroke unit. PA was assessed with Saltin-Grimbys 4-level Physical Activity Level Scale, and stroke severity was assessed with the National Institutes of Health Stroke Scale (NIHSS). Logistic regression was used to predict stroke severity, and negative binomial regression was used to compare the level of PA and stroke severity.. RESULTS: The study included 925 patients with a mean age of 73.1 years, and 45.2% were women. Patients who reported light or moderate PA levels were more likely to present a mild stroke (NIHSS score 0 to 5) compared with physically inactive patients in a model that also ...
MUDZI, W; STEWART, A and MUSENGE, E. Case fatality of patients with stroke over a 12-month period post stroke. SAMJ, S. Afr. med. j. [online]. 2012, vol.102, n.9, pp.765-767. ISSN 2078-5135.. INTRODUCTION: Stroke is among the top 4 causes of death in South Africa and the top 10 leading causes of disability worldwide. There is a dearth of literature on stroke incidence, prevalence and outcome in sub-Saharan Africa. We aimed to establish the case fatality of stroke patients over a 12-month period post discharge from hospital. METHODS: A total of 200 patients with first-time ischaemic stroke were recruited from Chris Hani Baragwanath Academic Hospital and followed up for 12 months. The Barthel Index (BI) and Rivermead Mobility Index (RMI) were used to establish patient functional ability and, by inference, stroke severity. Follow-up assessments were performed at 3, 6 and 12 months post discharge. Data analysis was largely descriptive in nature. RESULTS: Thirty-eight per cent of patients died within ...
Background: Nationwide data on the clinical profile and outcomes of ischemic stroke in younger adults are still scarce. Our aim was to analyze clinical characteristics and outcomes of young patients with first-ever ischemic stroke compared to older patients.Methods: The National Acute Stroke ISraeli (NASIS) registry is a nationwide prospective hospital-based study performed triennially. Younger adults, aged 50 years and younger, were compared with patients, aged 51-84 years regarding risk factors, clinical presentation, stroke severity, stroke etiology and outcomes. A logistic model for stroke outcome was fitted for each age group. Results: 336 first-ever ischemic strokes were identified among patients aged 50 years and younger and 3,243 among patients 51-84 years. Younger adults had lower rates of traditional vascular risk factors, but 82.7% had at least one of these risk factors. Younger adults were more likely to be male (62.8%), current smokers (47.3%), and to have a family history of stroke (7.4%).
After a patient has a stroke, physicians must begin treatment as quickly as possible to minimize damage. Researchers at Cornell Universitys Baker Institute for Animal Health, have developed a stroke diagnosis device that takes only ten minutes and a small drop of the patients blood to generate a result.. Currently, stroke diagnosis takes up to three hours and requires skilled technicians to perform the lab work. These are hours that stroke victims could be receiving treatment, as earlier intervention has been shown to lead to better outcomes.. The study - which was published in the journal, PLOS One - demonstrated the proof of principal for the medical diagnostic device. The researchers say with further development, the tool could be used in hospital emergency rooms to diagnose stroke along with other conditions such as concussion, dementia and even heart disease and cancer.. According to Roy Cohen, a Research Scientist at the Baker Institute, and the studys lead author, the technology ...
TY - JOUR. T1 - Performance and Training Standards for Endovascular Ischemic Stroke Treatment. AU - Meyers, Philip M.. AU - Schumacher, H. Christian. AU - Alexander, Michael J.. AU - Derdeyn, Colin P.. AU - Furlan, Anthony J.. AU - Higashida, Randall T.. AU - Moran, Christopher J.. AU - Tarr, Robert W.. AU - Heck, Donald V.. AU - Hirsch, Joshua A.. AU - Jensen, Mary E.. AU - Linfante, Italo. AU - McDougall, Cameron. AU - Nesbit, Gary M.. AU - Rasmussen, Peter A.. AU - Tomsick, Thomas A.. AU - Wechsler, Lawrence R.. AU - Wilson, John R.. AU - Zaidat, Osama O.. PY - 2009/11/1. Y1 - 2009/11/1. N2 - Stroke is the third-leading cause of death in the United States, Canada, Europe, and Japan. According to the American Heart Association and the American Stroke Association, 750,000 new strokes occur each year, resulting in 200,000 deaths (or 1 of every 16 deaths) per year in the United States alone. Endovascular therapy for patients with acute ischemic stroke is an area of intense investigation. The ...
Stroke is a major cause of disability and the long-term effects of stroke often lead to need of rehabilitation services. It has been shown that intensive stroke unit care and functional exercises are beneficial in the acute rehabilitation of stroke. The duration of the rehabilitation of patients with acute stroke is decreasing, leaving patients with not complete recovery at discharge in need of follow-up services. There is a general assumption that physical exercises are beneficial at all stages of stroke but it is questionable if these benefits are sustained after treatment ends. There are, to our knowledge, no longitudinal studies of non-interrupted regular physical exercises from the acute phase till one year post stroke.. The purpose of this project is to follow first-ever- acute stroke patients from onset, one, two and four years post stroke. All acute stroke patients will be treated in a stroke unit and the physiotherapy treatment will be according to Motor Relearning Programme principles ...
... Cochrane Database Syst Rev. 2008;(3):CD000029. Authors: Sandercock PA, Counsell C, Gubitz GJ, Tseng MC. BACKGROUND: In patients with acute ischaemic stroke, platelets become activated. Antiplatelet therapy might reduce the volume of brain damaged by ischaemia and reduce the risk of early recurrent ischaemic stroke. This might reduce the risk of early death and improve long-term outcome in survivors. However, antiplatelet therapy might also increase the risk of fatal or disabling intracranial haemorrhage. OBJECTIVES: To assess the efficacy and safety of antiplatelet therapy in acute ischaemic stroke. SEARCH STRATEGY: We searched the Cochrane Stroke Group Trials Register (last searched June 2007), the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library Issue 2, 2007), MEDLINE (June 1998 to May 2007), and EMBASE (June 1998 to May 2007). In 1998, for a previous version of this review, we searched the register of the ...
University of Glasgow. About stroke. Approximately 150,000 people suffer a stroke in the UK each year. The vast majority of these strokes are ischaemic in nature, caused by a blockage of blood flow in the brain (as opposed to a haemorrhagic or bleeding stroke). Approximately one half of all stroke survivors are left with permanent disabilities as a result of the damage caused to brain tissue arising from the stroke. The annual health and social costs of caring for these patients is estimated to be in excess of £5 billion in the UK, with stroke patients estimated to be occupying at least 25 per cent of long term hospital beds.. The only current treatment for ischaemic stroke patients occurs in the acute phase of the condition (within several hours of the stroke), when anti-clotting agents are administered to dissolve the clot causing the blockage in blood flow to the brain. Only a small proportion of patients get to the hospital in time to be treated in this way.. Beyond the acute phase, there ...
© 2015 World Stroke Organization. Background: Aspirin is of moderate overall benefit for patients with acute disabling ischemic stroke. It is unclear whether functional outcome could be improved after stroke by targeting aspirin to patients with a high risk of recurrent thrombosis or a low risk of haemorrhage. Aims: We aimed to determine whether patients at higher risk of thrombotic events or poor functional outcome, or lower risk of major haemorrhage had a greater absolute risk reduction of poor functional outcome with aspirin than the average patient. Methods: We used data on individual ischemic stroke patients from three large trials of aspirin vs. placebo in acute ischemic stroke: the first International Stroke Trial (n=18372), the Chinese Acute Stroke Trial (n=20172) and the Multicentre Acute Stroke Trial (n=622). We developed and evaluated clinical prediction models for the following: early thrombotic events (myocardial infarction, ischemic stroke, deep vein thrombosis and pulmonary embolism);
It is an object of the invention to present an input and display apparatus for handwritten characters capable of freely editing input handwritten characters. A handwritten character entered on a touch panel by using a pen is registered as one stroke data. The registered one stroke data is divided in two stroke data by using the pen, or two stroke data are combined into one stroke data. By combination of stroke data division and combination, partial deletion in stroke data, blank insertion in stroke data, and insertion of other stroke data into stroke data are realized.
We use experimental models to understand the short-term and long term consequences of ischemic stroke, and our goal is to develop stroke therapies, using compounds that can modify the brain and immune system, to improve stroke recovery.. We are especially interested in sex differences in stroke. Young females are less likely to experience a stroke as compared to young males. However, after the age of 50+, women are equally likely to suffer a stroke as compared to men. At older ages, many more women will get a stroke as compared to men, and their stroke are likely to be worse, resulting in greater mortality, disability and loss of independence. Women are also more likely to exhibit post-stroke depression.. Stroke outcomes can be modified by environmental and developmental factors, and in turn stroke can also lead to other disabilities, such as epilepsy, addiction, depression. In conjunction with our colleagues at the TAMHSC COM and TAMIN, we are studying these issues in an animal model.. Stroke ...
BACKGROUND AND PURPOSE Ischemic stroke has a strong familial component to risk. The Siblings With Ischemic Stroke Study (SWISS) is a genome-wide, family-based analysis that included use of imputed genotypes. The Siblings With Ischemic Stroke Study was conducted to examine the associations between single-nucleotide polymorphisms (SNPs) and risk of stroke and stroke subtypes within pairs. METHODS The Siblings With Ischemic Stroke Study enrolled 312 probands with ischemic stroke from 70 US and Canadian centers. Affected siblings were ascertained by centers and confirmed by central record review; unaffected siblings were ascertained by telephone contact. Ischemic stroke was subtyped according to Trial of Org 10172 in Acute Stroke Treatment criteria. Genotyping was performed with an Illumina 610 quad array (probands) and an Illumina linkage V array (affected siblings). SNPs were imputed by using 1000 Genomes Project data and MACH software. Family-based association analyses were conducted by using the
To the best of our knowledge, this is the first report of an association between the location of acute infarcts and PSF outcome. The main finding is that subcortical white matter infarcts are associated with persistent fatigue 15 months after the index stroke in patients with well-established stroke.. A few studies have evaluated the possible impact of lesion location on PSF at the chronic stage of stroke, with negative results. Schepers et al. [25] did not find any association between laterality or type of stroke (ischemic vs haemorrhagic) and PSF at 1 year poststroke in 167 stroke patients [2]. Another study on 253 patients also found that stroke type was not related PSF at 1 year poststroke [6]. No association was found between PSF at 1.5 years poststroke and lesion location or white matter hyperintensities [3], and no relationship was found between lesion site and PSF 1 year poststroke in 99 stroke survivors [4]. Type or laterality of stroke was not related to increased fatigue in 242 ...
A stroke is a serious, life-threatening medical condition that occurs when the blood supply to part of the brain is cut off.. Strokes are a medical emergency and urgent treatment is essential because the sooner a person receives treatment for a stroke, the less damage is likely to happen.. Salford Royal is the Comprehensive Stroke Centre for the Greater Manchester Clinical Stroke Network.. Our Acute Stroke Unit, which treats people as soon as possible after symptoms start, has been providing specialist life-saving treatment for patients from across Greater Manchester since 2004.. Stroke research is an important part pf the stroke services at Salford and a wide range of studies involving stroke and the emergency conditions affecting the brain take place here.. The research we carry out looks at the causes and treatment of stroke. We are also interested in bleeding that happens in the brain tissue (intracerebral haemorrhage) and within the area around the brain (subarachnoid haemorrhage). The ...
Diagnosis and treatment of acute stroke has advanced considerably in the past 2 decades. Most notably, in cases of ischemic stroke, intravenous alteplase has become the standard of medical treatment despite its multiple contraindications and limited time window. More recently, trials have proven that endovascular thrombectomy is superior to medical therapy alone, advancing the standard of care for patients who present with acute ischemic stroke from a large vessel occlusion and salvageable brain tissue. The treatment of hemorrhagic stroke now involves the use of novel pharmacological agents and advanced minimally invasive technology. Important changes have also occurred at the levels of hospital organization and treatment decision-making. Such changes in organization and designation of hospitals with distinct levels of stroke care and the variety of stroke protocols now requires team work of emergency medical services (EMS), Emergency Department, stroke neurologists, neurosurgeons, and
Background: Continuous changes in stroke treatment and care, as well as changes in stroke characteristics, may alter stroke outcome over time. The aim of this paper is to describe time trends for treatment and outcome data, and to discuss if any such changes could be attributed to quality changes in stroke care. Methods: Data from Riks-Stroke, the Swedish stroke register, were analyzed for the time period of 1995 through 2010. The total number of patients included was 320,181. The following parameters were included: use of computed tomography (CT), stroke unit care, thrombolysis, medication before and after the stroke, length of stay in hospital, and discharge destination. Three months after stroke, data regarding walking, toileting and dressing ability, as well social situation, were gathered. Survival status after 7, 27 and 90 days was registered. Results: In 1995, 53.9% of stroke patients were treated in stroke units. In 2010 this proportion had increased to 87.5%. Fewer patients were ...
Background: Inverse associations between IQ and stroke have been reported in a few studies, but none of them has investigated subtypes of stroke, nor have they studied both fatal and non-fatal stroke separately. Stroke is a heterogenic disease and strength of associations with IQ and putative causal pathways cannot be assumed to be identical for different subtypes of stroke.. Methods: IQ was measured for 1.1 million Swedish men, born 1951 to 1976, during military conscription. We linked data from several national registers and followed the cohort until the end of 2006 for non-fatal, and 2004 for fatal stroke. Hazard ratios (HR) with 95% confidence intervals (CI) adjusted for age, BMI, blood pressure and socioeconomic factors were estimated using Cox proportional hazards models.. Results: We found inverse associations between IQ and all stroke subtypes, fatal and non-fatal, and that the strength of the associations differed by subtype, with the strongest relative risk found for hemorrhagic ...
Methodists 5K Walk/Run is part of a comprehensive initiative called Taking Strides4Stroke: Community Stroke Awareness Campaign. Led by the Methodist Neurological Institute, the campaign promotes education and awareness of stroke symptoms, treatment, prevention and research. Since the creation of the Stride4Stroke campaign in 2007, Methodists stroke educators have worked with more than 35,000 people in the greater Houston area. They have also assisted more than 20 Texas hospitals, including Memorial Medical Center-Lufkin through the support of the T.L.L. Temple Foundation, to become certified Primary Stroke Centers that meet the specialized needs of stroke patients.. ...
Methods and Results-Data from acute ischemic stroke patients treated with tPA within 3 hours of symptom onset in 1082 hospitals participating in the Get With the Guidelines-Stroke Program from April 1, 2003, to September 30, 2009 were studied to determine frequency, patient and hospital characteristics, and temporal trends in patients treated with door-to-needle times ≤60 minutes. Among 25 504 ischemic stroke patients treated with tPA, door-to-needle time was ≤60 minutes in only 6790 (26.6%). Patient factors most strongly associated with door-to-needle time ≤60 minutes were younger age, male gender, white race, or no prior stroke. Hospital factors associated with ≤60 minute door-to-needle time included greater annual volumes of tPA-treated stroke patients. The proportion of patients with door-to-needle times ≤60 minutes varied widely by hospital (0% to 79.2%) and increased from 19.5% in 2003 to 29.1% in 2009 (P,0.0001). Despite similar stroke severity, in-hospital mortality was lower ...
Strokes can be classified into two main categories: ischemic strokes and hemorrhagic strokes. An ischemic stroke occurs when a blood vessel that supplies the brain becomes blocked or "clogged" and impairs blood flow to part of the brain. The brain cells and tissues begin to die within minutes from lack of oxygen and nutrients. The area of tissue death is called an infarct. About 88 percent of strokes fall into this category. Ischemic strokes are further divided into two groups, including the following:. thrombotic strokes -strokes caused by a thrombus (blood clot) that develops in the arteries supplying blood to the brain. This type of stroke is usually seen in older persons, especially those with high-cholesterol levels and atherosclerosis (a build-up of fat and lipids inside the walls of blood vessels).. Sometimes, symptoms of a thrombotic stroke can occur suddenly and often during sleep or in the early morning. At other times, it may occur gradually over a period of hours or even days. This ...
Theyre called "wake-up strokes" because you go to bed feeling normal, then wake up with stroke symptoms.. Unfortunately, this makes it difficult for doctors to determine exactly when the stroke began - and clot-dissolving drugs have been considered effective only if given within 4 1/2 hours of when a stroke started.. But preliminary research shows that clot-busting treatments appear to be safe for wake-up strokes if patients can get to the emergency room quickly, according to a new study presented today at the American Stroke Associations annual international conference in New Orleans.. In the study of 326 stroke patients at a London medical center, researchers found that wake-up stroke patients treated with the drugs had similar death rates, risk of bleeding inside the brain, and recovery rates when compared to regular stroke patients treated within the 4 1/2-hour window.. Doctors have been reluctant to give clot-busting drugs without knowing when symptoms began because of the bleeding risk, ...
Recurrent strokes make up almost 25% of the nearly 800,000 strokes that occur annually in the United States. Risk factors for ischemic stroke include hypertension, diabetes mellitus, hyperlipidemia, sleep apnea, and obesity. Lifestyle modifications, including tobacco cessation, decreased alcohol use, and increased physical activity, are also important in the management of patients with a history of stroke or transient ischemic attack. Antiplatelet therapy is recommended to reduce the risk of recurrent ischemic stroke. The selection of antiplatelet therapy should be based on timing, safety, effectiveness, cost, patient characteristics, and patient preference. Aspirin is recommended as initial treatment to prevent recurrent ischemic stroke. Clopidogrel is recommended as an alternative monotherapy and in patients allergic to aspirin. The combination of clopidogrel and aspirin is not recommended for long-term use (more than two to three years) because of increased bleeding risk. Aspirin/dipyridamole is at
Our results for diabetes duration are consistent with prior research conducted within a general population of patients, which found an increased rate of ischemic stroke as duration increased compared with nondiabetic patients (9,10). However, our results for HbA1c in diabetic patients with AF are not consistent with prior research conducted in diabetic patients in general. In our study, increased HbA1c did not have a substantial effect on the rate of ischemic stroke, whereas elevated HbA1c was significantly associated with ischemic stroke in predominantly non-AF populations (11-13). A possible reason for HbA1c having no association with ischemic stroke in diabetic patients with AF is the difference in the primary mechanism for stroke in diabetic patients with and without AF. Among patients with diabetes without AF, stroke is often due to underlying atherosclerosis (22,23). This mechanism may not be as important among diabetic patients with AF, because the primary mechanism for ischemic stroke is ...
University Hospitals Neurological Institute Stroke Center in Cleveland, Ohio, invests in clinical research for stroke treatment to increase the chances of survival and optimize the quality of life for stroke patients.
The fellowship consists of 9 months of clinical rotations - typically, 6 months on the inpatient Stroke Service, 3 months in the Neurocritical care service - and 3 months elective/research time. During the months of in-patient stroke service, two fellows cover the different services which include in-patient stroke and stroke consultation. The fellow in charge of the in-patient service will supervise neurology residents and interns, lead morning rounds and teach stroke-related topics as well as do bedside neurological examination teaching. The consultation fellow will be receiving calls for consultations from outside hospitals for acute stroke transfers, will management acute stroke patients including tPA and thrombectomy and review stroke consultation from the ED and in-patient service from Stanford Hospital. He/she will also be responsible for telestroke calls. Both fellows are always supported by a stroke attending for any questions. Stroke attending also attend the transfer and telestroke ...
BACKGROUND: Previous studies conducted between 1997 and 2003 estimated that the risk of stroke or an acute coronary syndrome was 12 to 20% during the first 3 months after a transient ischemic attack (TIA) or minor stroke. The TIAregistry.org project was designed to describe the contemporary profile, etiologic factors, and outcomes in patients with a TIA or minor ischemic stroke who receive care in health systems that now offer urgent evaluation by stroke specialists. METHODS: We recruited patients who had had a TIA or minor stroke within the previous 7 days. Sites were selected if they had systems dedicated to urgent evaluation of patients with TIA. We estimated the 1-year risk of stroke and of the composite outcome of stroke, an acute coronary syndrome, or death from cardiovascular causes. We also examined the association of the ABCD(2) score for the risk of stroke (range, 0 [lowest risk] to 7 [highest risk]), findings on brain imaging, and cause of TIA or minor stroke with the risk of recurrent stroke
CSCA has enrolled 433 264 patients with acute stroke/TIA from 1576 hospitals. The patient and hospital baseline characteristics were reported. Compared with the previous hospitalised stroke registries, CSCA represents a large-scale effort to translate efficacy into effectiveness in stroke/TIA care for hospitalised patients covering all regions of China (except for Hong Kong, Taiwan and Macao regions). Patients with IS from CSCA have the similar patients demographic and clinical characteristics of China National Stroke Registry (CNSR) I and II, such as patients age, race, history of stroke/TIA, hypertension disease and diabetes mellitus.14 This programme also provides a unique platform to track the characteristics, process of care and outcomes of patients with stroke/TIA. Specifically, the CSCA provides opportunities to promote stroke centre construction and increase adherence to evidence-based performance metric in clinical practice. Through the CSCA, participating hospitals self-assess their ...
Title: Prevention of Ischemic Stroke: Antithrombotic Therapy in Cardiac Embolism. VOLUME: 8 ISSUE: 7. Author(s): A. Cervera, S. Amaro, V. Obach and A. Chamorro. Affiliation:Institute of Clinical Neurosciences,Hospital Clinic, 170 Villarroel, 08036 Barcelona, Spain.. Keywords:Stroke, cardioembolism, atrial fibrillation, antithrombotic therapy. Abstract: Ischemic stroke secondary to cardiac disease accounts for approximately 30% of all stroke subtypes and it may be due to a large list of conditions. Stroke secondary to heart disease causes more severe deficits, higher mortality, and increased costs that other stroke subtypes. Therefore, proper identification of cardioembolic stroke is crucial for adequate selection of optimal preventive strategies. Identification of stroke prone individuals with heart disease could also have an important therapeutic impact. This manuscript reviews the interaction between the heart and brain with a particularly emphasis in the current state of older and newer ...
TY - JOUR. T1 - The Essen Stroke Risk Score predicts recurrent cardiovascular events A validation within the REduction of Atherothrombosis for Continued Health (REACH) registry. AU - Weimar, Christian. AU - Diener, Hans Christoph. AU - Alberts, Mark J.. AU - Gabriel Steg, P.. AU - Bhatt, Deepak L.. AU - Wilson, Peter W F. AU - Mas, Jean Louis. AU - Röther, Joachim. PY - 2009/2. Y1 - 2009/2. N2 - Background and Purpose-Predictive scores are important tools for stratifying patients based on the risk of future (cerebro)vascular events and for selecting potential prevention therapy. Recently, the Essen Stroke Risk Score (ESRS) was derived from cerebrovascular patients in the Clopidogrel versus Aspirin in Patients at Risk of Ischemic Events (CAPRIE) trial. We aimed to validate the ESRS in a large cohort of outpatients with previous transient ischemic attack or stroke from the REduction of Atherothrombosis for Continued Health (REACH) Registry. Methods-We included 15 605 outpatients with a qualifying ...
Stroke is an important public health problem worldwide. It is a non-communicable disease of increasing importance in the ageing population. There are four major types of stroke: a) ischaemic stroke, b) primary intracerebral haemorrhage, c) subarachnoid haemorrhage and d) undetermined stroke (no computed tomography [CT], magnetic resonance imaging [MRI], autopsy or cerebral angiography). The risk factors and fatalities for stroke vary worldwide and stroke accounts for about 9.7% of all deaths worldwide. Unfortunately, most stroke deaths occur in the less developed countries, where stroke research is scanty. Patients who survive stroke will have a wide range of functional limitations that affect their daily activities. To date, only few reliable data are available for identifying the risk factors and understanding the stroke fatalities in the low- and middle-income countries. The effect of stroke on daily activities is also understudied. Measuring the effect of stroke on daily activities is ...
Although stroke is a disease of the brain, it can affect the entire body. A common disability that results from stroke is complete paralysis on one side of the body, called hemiplegia. A related disability that is not as debilitating as paralysis is one-sided weakness or hemiparesis. Stroke may cause problems with thinking, awareness, attention, learning, judgment, and memory. Stroke survivors often have problems understanding or forming speech. A stroke can lead to emotional problems. Stroke patients may have difficulty controlling their emotions or may express inappropriate emotions. Many stroke patients experience depression. Stroke survivors may also have numbness or strange sensations. The pain is often worse in the hands and feet and is made worse by movement and temperature changes, especially cold temperatures.. Recurrent stroke is frequent; about 25 percent of people who recover from their first stroke will have another stroke within 5 years.. ...
Hematological disorders underlie a small proportion of all ischemic strokes. The association of these coagulation abnormalities with ischemic stroke is not always clear. The etiology of stroke still remains uncertain in a large number of cases and proper screening for coagulation abnormalities and the discovery of new coagulation disorders will probably increase the rate of strokes attributable to these causes. Since large case-control studies with unselected and consecutive stroke patients from different ethnic origins have not yet been performed to determine the role of coagulation abnormalities in ischemic stroke, our knowledge is dependent on case reports and small series of mostly younger patients. Extensive hematologic evaluation of unselected stroke patients will likely yield little useful information and be too expensive. Every stroke patients needs a careful evaluation, and in selected cases, this should include coagulation parameters. Patients with unexplained strokes after a careful
These courses are broken down into the regional locations where there is a CHSS stroke education facilitator. Please scroll down to see all locations and the links for further details. Dumfries and Galloway. Contact: Elaine Grubb, Stroke Education Facilitator for NHS Dumfries & Galloway. Tel: 07843 211656, Email: [email protected] More information and booking form Fife. Contact: Joanne Graham, Stroke Education Facilitator,. Tel: 01383 565379 , E-mail: [email protected] More information and booking form Grampian. Contact: Fiona Sales, Stroke Education Facilitator. Tel: 01224 556150, Email: [email protected] More information and booking form Lanarkshire. Contact: Gillian Taylor, Stroke Education Facilitator. Telephone: 01236 707582, Mobile: 07805771058, Email: [email protected] More information and booking form Lothian and Borders. Contact: Gillian Currie, Stroke Education Facilitator. Tel: 0131 225 6963, Email: [email protected] More information and ...
Stroke is the third leading cause of death and an important source of disability in Taiwan. The majority of stroke is ischemic stroke. There is about 20.9% of ischemic stroke patient onset before 55 years old. Cardioembolism and premature atherosclerosis were the most two important factors related to the development of early-onset ischemic stroke. Recently, it has been reported that a dysfunctional telomere pathway may lead to impaired DNA damage repair, genomic instability, and ultimately, the initiation of atherosclerosis, which is one of the important causes of ischemic stroke in young adults. However, few studies investigate the relationship between the genetic polymorphisms of telomere length pathway genes, and the risk and severity of early-onset ischemic stroke. In this project, a total of 1000 early-onset ischemic stroke cases confirmed with computerized tomographic scan and/or magnetic resonance imaging will be recruited from seven hospitals (NTUH, SKH, CMMC, TSGH, TMUH, SHH and WFH). A ...
The effectiveness of methods to prevent stroke recurrence and of education focusing on learners needs has not been fully explored. The aims of this study were to assess the effects of such interventions among stroke patients and their primary caregivers and to evaluate the feasibility of a web-based stroke education program. The participants were 36 patients with a clinical diagnosis of ischemic stroke within 12 months post-stroke and their primary caregivers. The participants were randomly assigned to either an experimental or a control group. The primary measures included blood chemistry, self-reported health behaviors, sense of control, and health motivation for stroke patients, and caregiver mastery for caregivers. To test the feasibility of the intervention program, the rates of participation and occurrence of technical problems were calculated. The experimental group tended to improve significantly more than the control group in terms of exercise, diet, sense of control and health ...
BACKGROUND AND PURPOSE: Few studies have evaluated long-term costs after stroke onset, with almost no cost data for transient ischemic attack (TIA). We studied hospital costs during the 5 years after TIA or stroke in a population-based study. METHODS: Patients from a United Kingdom population-based cohort study (Oxford Vascular Study) were recruited from 2002 to 2007. Analysis was based on follow-up until 2010. Hospital resource usage was obtained from patient hospital records and valued using 2008/2009 unit costs. Because not all patients had full 5-year follow-up, we used nonparametric censoring techniques. RESULTS: Among 485 TIA and 729 stroke patients ascertained and included, mean censor-adjusted 5-year hospital costs after index stroke were $25,741 (95% confidence interval, 23,659-27,914), with costs varying considerably by severity: $21,134 after minor stroke; $33,119 after moderate stroke; and $28,552 after severe stroke. For the 239 surviving stroke patients who had reached final follow-up,
BACKGROUND We explored the safety of intravenous thrombolysis (IVT) or intra-arterial treatment (IAT) in patients with ischemic stroke on non-vitamin K antagonist oral anticoagulants (NOACs, last intake ,48 hours) in comparison with patients (1) taking vitamin K antagonists (VKAs) or (2) without previous anticoagulation (no-OAC). METHODS AND RESULTS This is a multicenter cohort pilot study. Primary outcome measures were (1) occurrence of intracranial hemorrhage (ICH) in 3 categories: any ICH (ICHany), symptomatic ICH according to the criteria of the European Cooperative Acute Stroke Study II (ECASS-II) (sICHECASS-II) and the National Institute of Neurological Disorders and Stroke (NINDS) thrombolysis trial (sICHNINDS); and (2) death (at 3 months). Cohorts were compared by using propensity score matching. Our NOAC cohort comprised 78 patients treated with IVT/IAT and the comparison groups of 441 VKA patients and 8938 no-OAC patients. The median time from last NOAC intake to IVT/IAT was 13 hours ...
There are people who are seldom sick most of their life, but then one stroke can leave them devastated both physically and mentally. The problem is that most people do not know the signs of an imminent stroke, especially when we are young and healthy. Unfortunately, stroke is an insidious disease. In the United States, more than 700,000 people suffer from a stroke each year. Of the two-thirds who survive, stroke survivors have to deal with varying levels of disabilities in speech, vision and movement (usually one-sided). Sometimes, stroke sufferers fall into comas because of the resulting brain damage. In China, many people also suffer from the stroke but the difference is that these patients receive better treatment in terms of stroke rehabilitation. They regain mobility and normal neural function more quickly. You may ask how this can be. In addition to a combination of physical, speech and occupational therapies, the standard protocol for Chinese stroke patients is to have immediate ...
The mean age of the patients was 73 years; 55% were white, and 68% were women. The most common determined causes of the strokes were small-vessel strokes (26%), cardioembolism (25%), and large-artery atherosclerosis (20%).. When the patients were examined by clinical subgroups, increased pollution levels were associated with stroke in patients with large-artery atherosclerosis (odds ratio 1.24) and small-vessel strokes (1.19), but not in patients with strokes due to cardioembolism. There was no evidence that comorbid diabetes, hypertension, atrial fibrillation, or a history of stroke increased susceptibility to pollution-related strokes, the researchers noted.. Although the observed relative risk of stroke was modest, the findings suggest that "if the association between stroke and pollution is causal and a linear dose-response occurs, a 2-microgram/m3 reduction in mean PM2.5 levels (approximately 20%) during this time period might have averted approximately 6,100 of the 184,000 stroke ...
The team induced a mild stroke similar to a silent stroke in the striatum area of the brain in mice. They found there was inflammation and brain damage in the striatum following the stroke, which they had expected. What the researchers didnt expect was the impact on another area of the brain, the substantia nigra. When they analysed the substantia nigra they recorded a rapid loss of Substance P (a key chemical involved in its functions) as well as inflammation. The team then analysed changes in the brain six days after the mild stroke and found neurodegeneration in the substantia nigra. Dopaminergic neurones had been killed.. Talking about the findings Dr Pinteaux said: "It is well known that inflammation following a stroke can be very damaging to the brain. But what we didnt fully appreciate was the impact on areas of the brain away from the location of the stroke. Our work identifying that a silent stroke can lead to Parkinsons disease shows it is more important than ever to ensure stroke ...
Stroke Risk Reduction: How likely am I to have a stroke?. High cholesterol can put you at a higher risk of stroke, but your exact risk depends on your overall health, including any other stroke risk factors you may have: Stroke risk factors you cant control High cholesterol and other stroke risk factors you can control Stroke risk factors you cant control If you have high cholesterol, youre already at risk of a stroke.
No other study has examined incident stroke hospitalizations and deaths in an entire country over 3 decades. The size of our study has allowed us to examine age- and sex-specific temporal trends in stroke incidence that until now have been poorly described. As with any study of this type there are limitations. Hospital discharge data will only identify patients admitted to hospital with stroke and will exclude those managed at home. Several community-based studies report that more than 80% of patients with stroke are managed in hospital, including the South London Stroke Register in which 85% of individuals with a first stroke were hospitalized between 1995 and 2002.12,20,22 Estimates vary, and this figure is likely to have increased over time. In the Perth Community Study, the proportion of individuals hospitalized over time increased from 78.5% in 1989 to 1990 to 92.3% in 2000 to 2001, although these figure are based on small numbers.20 In addition, by including fatal stroke events we will ...
Neonatal stroke is similar to the stroke that occurs in adults and produces a significant morbidity and long-term neurologic and cognitive deficits. There are important differences in the factors, inical events and outcomes associated with the stroke in infants and adults. However, anisms underlying age differences in the stroke development remain largely unknown. Therefore, treatment guidelines for neonatal stroke must extrapolate from the adult data that is often not suitable for children. The new information about differences between neonatal and adult stroke is essential for identification of significant areas for future treatment and effective prevention of neonatal stroke. Here, we studied the development of stress-induced hemorrhagic stroke and possible mechanisms underlying these processes in newborn and adult rats. Using histological methods and magnetic resonance imaging, we found age differences in the type of intracranial hemorrhages. Newborn rats demonstrated small superficial ...
Imagine.. Imagine the joy and anticipation of childbirth.. Imagine the shock and anquish to discover your child has had a stroke.. My name is Anne Hosterman and Id like to introduce you to my daughter Leah. She is a beautiful, loving 8 year old who is full of life with an amazing laugh and infectious smile. She loves to sing, dance and swim. Her true love is Disney World where she wants to live as a real life princess!. Leah had a massive stroke at birth, resulting in cerebral palsey and arthritis. She is known as a right hemi, meaning she has a weakened right side and has limited use of her right hand. She struggles everyday to do the simplist of things Leah has had numerous surgeries and has therapy daily.. While strokes in children are as common as childhood brain tumors and cancer, most people are unaware that infants and children can have strokes.. Pediatric stroke research is severly underfunded. Our goal is to raise awareness and funds to be directed to pediatric stroke research which ...
MONDAY, April 10, 2017 (HealthDay News) -- Strokes are typically associated with the elderly, but new research suggests that strokes are increasingly happening to Americans under 65. The study looked at a sample of data from some U.S. stroke hospitalizations. From 2003 to 2004 in this sample, more than 141,000 people from 18 to 65 were admitted to hospitals for stroke. By 2011 to 2012, that number had risen to more than 171,000, researchers found.. "Our results stress the importance of prevention of stroke risk factors in younger adults," said lead author Dr. Mary George. Shes a senior medical officer with the U.S. Centers for Disease Control and Preventions division of heart disease and stroke prevention. "Young adults, ages 18 to 54, are experiencing a small but sustained increase in stroke and in the prevalence of traditional stroke risk factors, such as high blood pressure, diabetes, high cholesterol, tobacco use and obesity," George said. Up to 80 percent of strokes are thought to be ...
Acute Ischemic Stroke Diagnosis and Treatment Market (By Diagnostics Type - CT, MRI, Ultrasound, Cerebral Angiography, Nuclear Imaging and Others By Surgery Type - Carotid Endarterectomy, Angioplasty and Endovascular Mechanical Thrombectomy) - Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 ...
Results We identified 27,662 first-ever stroke and 2,909 recurrent events during an average of 7.0 years of follow-up. Compared with excellent general SRH, the hazard ratios (HRs) and 95% confidence intervals (CIs) for first-ever stroke associated with good, fair, and poor general SRH were 1.04 (1.00 to 1.08), 1.19 (1.15 to 1.23), and 1.49 (1.42 to 1.56) in the multivariate model, respectively. Compared with better age-comparative SRH, the HRs (95% CIs) of same and worse age-comparative SRH were 1.13 (1.10 to 1.17) and 1.51 (1.45 to 1.58), respectively. The relations of SRH measures with ischemic stroke, hemorrhagic stroke, and recurrent stroke were similar to that with total first-ever stroke. However, the magnitude of associations was much stronger for fatal stroke than for non-fatal stroke. ...
SAN FRANCISCO -- Closure of a patent foramen ovale (PFO) incidentally discovered during cardiothoracic surgery does not improve survival and may actually increase stroke risk rather than reducing it a
1. Abou-Chebl A. Endovascular treatment of acute ischemic stroke may be safely performed with no time window limit in appropriately selected patients. Stroke. 2010. 41: 1996-2000. 2. Ahn JY, Han IB, Chung SS, Chung YS, Kim SH, Yoon PH. Endovascular thrombolysis and stenting of a middle cerebral artery occlusion beyond 6 hours post-attack: Special reference to the usefulness of diffusion-perfusion MRI. Neurol Res. 2006. 28: 881-5. 3. Amenta PS, Ali MS, Dumont AS, Gonzalez LF, Tjoumakaris SI, Hasan D. Computed tomography perfusion-based selection of patients for endovascular recanalization. Neurosurg Focus. 2011. 30: E6-. 4. Barber PA, Zhang J, Demchuk AM, Hill MD, Buchan AM. Why are stroke patients excluded from TPA therapy?. An analysis of patient eligibility. Neurology. 2001. 56: 1015-20. 5. Brekenfeld C, Schroth G, Mattle HP, Do DD, Remonda L, Mordasini P. Stent placement in acute cerebral artery occlusion: Use of a self-expandable intracranial stent for acute stroke treatment. Stroke. 2009. ...
Hippocrates (460-377 BC) first described stroke over 2400 years ago. Stroke is the 4th leading cause of death in Canada (3rd in the USA) and the primary cause of permanent motor and cognitive disability. The majority of strokes are ischemic. The extent of cerebral dysfunction and thus the severity of stroke are based on the location, severity and duration of ischemia. Stroke management and prognosis encompass early recognition of the onset of stroke and post-stroke determination of the extent of brain injury aided by clinical stroke scores and diffusion-weighted imaging. Cognitive domains most likely to be affected following stroke are memory, orientation, language, attention and executive function. While the vast majority of functional recovery occurs within the first 3 months post-stroke, the neural mechanisms promoting recovery are not well understood. Investigations into the neural plasticity of brain areas after a lesion demonstrate that the adult brain can be shaped by environmental inputs, such
Introduction. Cerebrovascular diseases are the most common cause of disability in adults and one of the main causes of death in Spain.1 In the specific case of Asturias, stroke has become the leading cause of death in women in the region and the third most frequent in men.2 Several treatment measures developed in recent decades have improved the prognosis of stroke patients. Such measures include the introduction of tissue plasminogen activator (IV tPA),3 approved in Europe in 2002, and the more recent validation of endovascular treatment for stroke secondary to large-vessel occlusion (LVO).4-10. Another important treatment measure was the 2006 Helsingborg Declaration,11 which proposed stroke units (SU) as the most effective hospital resource for managing acute stroke and established a clear objective for 2015: to ensure that all stroke patients receive assessment in a stroke unit.. In light of the above, the creation of a coordinated code stroke (CS) protocol tailored to the specific needs of ...
Prof Armand Lowenthal, the Principal Investigator and Chairman of the European Stroke Prevention Study-2 (ESPS-2), presented the findings of this large trial at the Congress of the European Federation of Neurological Societies in Marseille, France, on September 11, 1995. In ESPS-2, 6602 patients with a history of stroke or transient ischemic attack were randomized to one of four groups: aspirin alone (50 mg/d), sustained-release dipyridamole alone (400 mg/d), aspirin plus sustained-release dipyridamole, or placebo. Medication was administered for a period of 2 years. Fifty-nine clinical centers in 13 European countries participated in the study. Two principal end points were defined: stroke or death from any cause. These end points were analyzed both separately and together. The incidence of stroke (both fatal and nonfatal) was relatively reduced by 18.1% with aspirin alone, by 16.3% with sustained-release dipyridamole alone, and by 37% with aspirin plus sustained-release dipyridamole. The ...
Background: Most ischaemic strokes are caused by blood clots blocking an artery in the brain. Clot prevention with anticoagulants might improve outcome if bleeding risks were low. This is an update of a Cochrane review first published in 1995, and previously updated in 2004. Objectives:To assess the effect of anticoagulant therapy versus control in the early treatment (less than 14 days) of Patients with acute ischaemic stroke. Search strategy: We searched the Cochrane Stroke Group Trials Register (last searched 2 October 2007), and two Internet clinical trials registries for relevant ongoing studies (last searched October 2007). Selection criteria: Randomised trials comparing early anticoagulant therapy (started within two weeks of stroke onset) with control in Patients with acute presumed or confirmed ischaemic stroke. Data collection and analysis: Two review authors independently selected trials for inclusion, assessed trial quality, and extracted the data. Main results: Twenty-four trials involving
The American Heart Association said one in three Americans were unable to recall any warning signs of a stroke, and a recent study by the group found that many women in the U.S. are unaware of what stroke warning signs are.
TY - JOUR. T1 - New advances in the diagnosis and management of cardioembolic stroke. AU - Lin, Mei Shu. AU - Chang, Nen Chung. AU - Lee, Tsung-Ming. PY - 2005/3. Y1 - 2005/3. N2 - Cardioembolic stroke accounts for one-fifth of ischemic stroke and is severe and prone to early recurrence. Magnetic resonance imaging, transcranial Doppler, echocardiography, 24-hour electrocardiographic monitoring and electrophysiological study are tools for detecting cardioembolic sources. Non-valvular atrial fibrillation (AF) is the most common cause of cardioembolic stroke and long-term anticoagulation is proved to prevent stroke. Despite knowledge of guidelines, doctors recommend anticoagulant for less than half of patients with AF who have risk factors for cardioembolic stroke and no contraindication for its usage. Direct thrombin inhibitor offers the advantage of not needing prothrombin time controls and dose adjustments, but it needs large clinical trial for confirmation. Any type of anticoagulant by any ...
TY - JOUR. T1 - Interrater reliability of an etiologic classification of ischemic stroke. AU - Johnson, C. J.. AU - Kittner, C. J.. AU - McCarter, R. J.. AU - Sloan, R. J.. AU - Stern, Barney. AU - Buchholz, David. AU - Price, T. R.. PY - 1995. Y1 - 1995. N2 - Precise identification of the cause of stroke is critical to research and clinical practice. Published series of ischemic stroke show considerable variation in the proportion of cases classified as atherosclerotic large-vessel disease, lacunar infarct, cardioembolic stroke, stroke of other known cause, and stroke of undetermined etiology. We describe the development and use of an etiology-specific classification of ischemic stroke. The interrater reliability of the classification is then evaluated. Methods A total of 160 cases of ischemic strokes in young adults were reviewed by paired neurologists who assigned cases to prioritized categories. The results of paired ratings were evaluated for each of the potential causes. Interrater ...
Ischemic stroke is major cause of disability and mortality worldwide, and aging is strong risk factor for poor post-stroke outcome. Neutrophils traffic rapidly to the brain following ischemic stroke, and recent evidence has suggested that aging may alter neutrophil function after tissue injury. In this study, we hypothesize that aging enhances the pro-inflammatory function of neutrophils, directly contributing to the poorer outcomes seen in aging patients. We utilized demographic data and biological specimens from ischemic stroke patients and an experimental mouse model to determine the correlation between age, neutrophil function and stroke outcomes. In ischemic stroke patients, age was associated with increased mortality and morbidity and higher levels of neutrophil-activating cytokines. In mice, aged animals had higher stroke mortality and morbidity, higher levels of neutrophil-activating cytokines and enhanced generation of neutrophil reactive oxygen species compared to young mice. Finally,
Recent trials of antithrombotic therapy in patients with coronary artery disease (CAD) have demonstrated substantial reductions in ischemic stroke. Our aim was to examine ischemic stroke risk in patients with CAD and to identify those at highest risk. We examined ischemic stroke risk in patients without atrial fibrillation who underwent coronary angiography between 2004 and 2012. Patients were stratified according to presence or absence of CAD and further stratified by extent of CAD (0 vessel disease [VD], 1 VD, 2 VD, 3 VD, and diffuse VD). End points were composites of ischemic stroke, transient ischemic attack (TIA), and systemic embolism, as well as major adverse cardiovascular and cerebrovascular events (MACCE) defined as cardiac death, myocardial infarction, plus ischemic stroke, TIA, and systemic embolism. Adjusted incidence rate ratios (IRRs) were estimated. A total of 68,829 patients were included, 25,032 had 0 VD, 4,736 had diffuse VD, 18,471 had 1 VD, 10,588 had 2 VD, and 10,002 had 3 ...
One in five strokes occurs in the posterior circulation, whose blood vessels (the vertebral and basilar arteries) supply the back of the brain. We have shown that posterior circulation TIA and minor stroke is followed by a high risk of further stroke.. One in five of these strokes is caused by narrowing of the vertebral arteries. Narrowing of the carotid artery (which supplies the front of the brain) can be successfully treated by surgery preventing further strokes. Surgical access to the vertebral arteries is difficult but it is now possible to access the narrowing by passing a wire up the artery and opening up the narrowing using a stent.. In pilot studies we and others have shown vertebral stenting appears to be relatively safe. It is now essential to evaluate in a large trial whether vertebral stenting prevents recurrent stroke. If so this treatment would be applicable to a large number of stroke and TIA patients.. In a number of specialised centres in the UK who already have expertise in ...
Background: - Stroke, also known as acute cerebrovascular attack, is the leading cause of long-term disability worldwide. Stroke survivors are often left with permanent physical and mental disabilities. - Many stroke patients receive different therapies in an attempt to improve their independence and quality of life. However, current strategies are focused on the acute stage after stroke and are of limited influence in improving stroke outcome. One of the main problems of patients who have suffered a stroke is the difficulty in using the hand on the opposite side of the affected hemisphere of the brain; to date, researchers have no successful means to improve the hand function in chronic stages of stroke. - Researchers are interested in developing a pool of individuals for further research into hand and motor function after a stroke. Objectives: - To perform a screening evaluation of patients referred with stroke to determine their eligibility for current and future protocols studying the ...
The faster the signs are spotted, the more of the person is saved.. It is often difficult to say why a person has a stroke and many people wont ever have an answer. It could be linked to an injury or medical conditions like blood-clotting disorders, diabetes or an irregular heartbeat. However, some strokes can be prevented, with regular exercise, healthy eating, not smoking and avoiding excessive drinking. The biggest risk factor for strokes is high blood pressure. The Stroke Association holds free blood pressure testing events because 40% of strokes could be prevented if its controlled.. The Stroke Association offers a range of life after stroke services, including the information, advice and support service. Staff work closely with hospital stroke teams to support people in their transition from hospital to home and onwards. The team provides a range of support to stroke survivors and their families, including information on useful local organisations and details of stroke and carers ...
Objective: To explore barriers and facilitators to staying in work following stroke. Design: Qualitative analysis of posts regarding staying in work following stroke using the archives of an online forum for stroke survivors. Participants: 60 stroke survivors (29M, 23F, 8 not stated; mean age at stroke 44y) who have returned to work, identified using terms return to work and back at work. Setting: Posts from UK stroke survivors and family members on Talkstroke, the forum of the Stroke Association, between 2004 and 2011. Results: Both stroke and Transient Ischaemic Attack (TIA) survivors reported residual impairments that for many had impact on work. Most impairments were invisible, including fatigue, problems with concentration, memory, and personality changes. Participants described both positive (e.g. back at work being better than expected) and negative work experiences, including being at risk of losing the job because of stroke-related impairments. Barriers to successfully staying in ...
This study demonstrates elevated readmission rates for ischemic and hemorrhagic stroke in the intermediate 30‐, 60‐, and 90‐day risk periods following common cardiac procedures relative to noncardiac procedures and common medical admissions. Ischemic stroke risk was highest following TAVR and LVAD, and hemorrhagic stroke risk was highest following LVAD, SAVR, and LAA closure. Aside from LAA closure, all cardiac procedures were associated with a higher readmission risk for stroke than noncardiac procedures. The ischemic stroke readmission rates following SAVR, cardiac catheterization, permanent pacemaker placement, and implantable cardioverter defibrillator placement were all higher than rates following admission with UTI, pneumonia, and COPD. Ischemic stroke readmission rates following LVAD and TAVR were higher than rates following admission with CHF. These results suggest that the cardiac procedures and postoperative management confer additional vulnerability to patients who have many ...
A stroke is medically refered to as an acute medical emergency otherswise known as a "Brain Attack" which affects the bodys blood circulation. This disruption happens due to a blockage of the systems blood vessels. This causes a decrease in the level of blood oxygen that travels to the brain as a result a person may encounter severe brain damage, disability and sometimes even death.. There are two kinds of treatment for stroke, that of an ischemic stroke and one used for a hemorrhagic stroke. After getting a stroke, the treatment should be given immediately or within hours following the stroke. When treating ischemic stroke a medical professional should aim to stabilize the patients vital signs by giving the patient medicines to stop blood from clotting The healing of hemorrhagic stroke aims to slow down bleeding and minimize swelling in the head. Normally when a doctor takes care of a patient for stroke they need to be notified of how long ago the symptoms occurred. They need to secure ...
Paras Hospitals | Paras Healthcare | Paras Panchkula Doctors Informative Video on Acute Stroke Management by Dr. (Prof.) Vivek Gupta, Sr. consultant
There are several proven strategies for prevention of recurrent ischemic stroke, including use of statins, treatment of hypertension, and anticoagulation in patients with atrial fibrillation. Preliminary analyses suggest that only 9-15% of Kaiser Permanente Northern Californias ischemic stroke patients receive optimal care for secondary prevention of stroke. The purpose of this study is to determine whether or not a quality improvement (QI) intervention can improve the care received by stroke patients. This project consists of a randomized trial of standardized stroke discharge order forms to improve adherence with best practices in secondary stroke prevention. The primary research question is: Is a secondary prevention intervention, focused on implementation of standardized pre-printed discharge orders for hospitalists, effective at increasing utilization of the following evidence-based treatments 6 months after discharge for ischemic stroke: (1) treatment with statins, (2) control of ...
TY - JOUR. T1 - World Stroke Day in Taiwan. T2 - Raising Public Awareness of Stroke. AU - Chan, Lung. AU - Lin, Yu Di. AU - Liu, Chieh Hsing. PY - 2016/9/1. Y1 - 2016/9/1. N2 - Background World Stroke Day (WSD) is an international campaign for raising stroke awareness according to the WSD proclamation. We investigated whether the 2012 WSD campaign organized in Taiwan fulfilled the requirements of the target population and improved stroke literacy among the attendees. Method A questionnaire survey regarding the 2012 WSD Taiwan campaign was administered by our trained interviewers to the attendees. Results In total, 350 attendees participated in the survey, and only 57.89% of the attendees identified the brain as the main damaged organ in stroke. Most attendees recognized ischemic stroke (85.94%) as a stroke type and hypertension (47%) as a common risk factor. The three most commonly recognized stroke symptoms were limb weakness, slurred speech, and facial weakness. Most attendees could seek ...
Sinn Féin MLA Pat Sheehan has welcomed a report calling for better care for stroke survivors and carers. The West Belfast MLA said: "I welcome the launch of the Stroke Associations Struggling to Recover report with recommendations on ways to meet the needs of patients and carers. "Community care is a fundamental part of stroke treatment and care. It is not a luxury that can be added on; it is a vital element of the wider stroke recovery pathway.. "This report highlights issues around gaps in the services, future areas of need. "It is clear that existing stroke services are not meeting the needs of patients and carers, particularly relating to community care. "We believe that every stroke survivor has the right to make the best possible recovery they can after stroke and that is what we are working towards." ...
Title: Dyslipidemia as a Risk Factor for Ischemic Stroke. VOLUME: 9 ISSUE: 14. Author(s):Konstantinos Tziomalos, Vasilios G. Athyros, Asterios Karagiannis and Dimitri P. Mikhailidis. Affiliation:Head of Atherosclerosis and Metabolic Syndrome Units, Second Propedeutic Department of Internal Medicine, Aristotle University, Hippocration Hospital, Thessaloniki, 55 132, Greece.. Keywords:ischemic stroke, hemorrhagic stroke, statins, fibrates, nicotinic acid, low density lipoprotein cholesterol, high density lipoprotein cholesterol, triglycerides. Abstract: Ischemic stroke is a major cause of morbidity and mortality. Whereas dyslipidemia is a major risk factor for coronary heart disease (CHD), its role in the pathogenesis of ischemic stroke is less clear. Epidemiological studies have provided conflicting findings regarding the association of dyslipidemia with ischemic stroke. Overall, elevated LDL-C levels appear to increase the risk of ischemic stroke. Low HDL-C levels also appear to be associated ...
A stroke (cerebral vascular accident or CVA) occurs when the blood supply to a part of the brain is cut off. This is caused by either a blood clot (ischaemic stroke - 80%) or a burst blood vessel (haemorrhagic stroke - 20%).. Symptoms that subside within a few minutes with full recovery may be caused by a mini stroke (transient ischaemic attack or TIA). This is often seen as a warning or temporary stroke. These should be taken seriously as an indicator of a full stroke. People who have a mini stroke have a 1-2 in 10 chance of full stroke within a month. Strokes are the third main cause of death in the UK (approximately 4.5million people every year).. A stroke is extremely serious requiring treatment straight away. The longer the brain is starved of oxygen, the greater the risk of brain damage.. Possible early signs and symptoms:. ...
This blog stands for faith in God and better stroke awareness. Everyone should be aware of stroke signs and know what to do. The life you save may be your own. Toward that end, stroke survivors and families are invited to share comments or stories. This is not designed to give anyone medical advice - we might talk about stroke care in general but always, always seek appropriate medical advice ...
Our Stroke Association Speech and Language Therapy (SLT) Communication Plus Programmes have been specially designed for stroke survivors who have developed aphasia as the result of a stroke. These 12 week group programmes are professionally led by a Speech and Language Therapist and focus on a Total Communication Approach to communicating (more than just speech). Stroke survivors will have an individual stroke recovery plan containing their communication goals and have the opportunity to meet and share experiences with other stroke survivors living with a communication disability after having a stroke.. ...
Summary The NIHR Dissemination Centre (NIHR DC) has released a themed review of NIHR research into the organisation of stroke services and care pathways. This review of 44 published and 29 ongoing studies covers recent research into stroke and acute stroke management, stroke recovery and rehabilitation, and also includes life after stroke. The main section…
Background. Dopamine is a key modulator of striatal function and learning and might improve motor recovery after stroke. Previous small trials of dopamine agonists after stroke provide equivocal evidence of effectiveness on improving motor recovery. We aimed to assess the safety and efficacy of co-careldopa plus routine occupational and physical therapy during early rehabilitation after stroke.. Methods. This double-blind, multicentre, randomised controlled trial of co-careldopa versus placebo in addition to routine NHS occupational and physical therapy was done at 51 UK NHS acute inpatient stroke rehabilitation services. We recruited patients with new or recurrent clinically diagnosed ischaemic or haemorrhagic (excluding subarachnoid haemorrhage) stroke 5-42 days before randomisation, who were unable to walk 10 m or more, had a score of less than 7 points on the Rivermead Mobility Index, were expected to need rehabilitation, and were able to access rehabilitation after discharge from hospital. ...
Atrial fibrillation is a predictor of in-hospital mortality in ischemic stroke patients Cheung-Ter Ong,1,2 Yi-Sin Wong,3 Chi-Shun Wu,1 Yu-Hsiang Su1 1Department of Neurology, Chia-Yi Christian Hospital, 2Department of Nursing, Chung Jen Junior College of Nursing, Health Science and Management, Chiayi, 3Department of Family Medicine, Chia-Yi Christian Hospital, Chiayi, Taiwan, Republic of China Background/purpose: In-hospital mortality rate of acute ischemic stroke patients remains between 3% and 18%. For improving the quality of stroke care, we investigated the factors that contribute to the risk of in-hospital mortality in acute ischemic stroke patients.Materials and methods: Between January 1, 2007, and December 31, 2011, 2,556 acute ischemic stroke patients admitted to a stroke unit were included in this study. Factors such as demographic characteristics, clinical characteristics, comorbidities, and complications related to in-hospital mortality were assessed.Results: Of the 2,556 ischemic
Thrombotic strokes are strokes caused by a thrombus (blood clot) that develops in the arteries supplying blood to the brain. This type of stroke is usually seen in older persons, especially those with high-cholesterol levels and atherosclerosis (a build-up of fat and lipids inside the walls of blood vessels).. Sometimes, symptoms of a thrombotic stroke can occur suddenly and often during sleep or in the early morning. At other times, it may occur gradually over a period of hours or even days. This is called a stroke-in-evolution.. Thrombotic strokes may be preceded by one or more "mini-strokes," called transient ischemic attacks, or TIAs. TIAs may last for a few minutes or up to 24 hours, and are often a warning sign that a stroke may occur. Although usually mild and transient, the symptoms caused by a TIA are similar to those caused by a stroke.. Another type of stroke that occurs in the small blood vessels in the brain is called a lacunar infarct. The word lacunar comes from the Latin word ...
There is a considerable overlap between vascular and Alzheimers disease (AD) risk factors. In addition, incident stroke approximately doubles the risk of developing AD. Oxidative stress is significantly involved in the pathogenesis of AD and suffers a dramatic increase in the setting of acute ischemic stroke, especially in cardioembolic stroke, followed by lacunar stroke, as shown in a previous study. Dampening this oxidative burst could delay the onset of subsequent dementia in stroke survivors.
OBJECTIVES: To perform a genome-wide association study (GWAS) using the Immunochip array in 3,420 cases of ischemic stroke and 6,821 controls, followed by a meta-analysis with data from more than 14,000 additional ischemic stroke cases. METHODS: Using the Immunochip, we genotyped 3,420 ischemic stroke cases and 6,821 controls. After imputation we meta-analyzed the results with imputed GWAS data from 3,548 cases and 5,972 controls recruited from the ischemic stroke WTCCC2 study, and with summary statistics from a further 8,480 cases and 56,032 controls in the METASTROKE consortium. A final in silico look-up of 2 single nucleotide polymorphisms in 2,522 cases and 1,899 controls was performed. Associations were also examined in 1,088 cases with intracerebral hemorrhage and 1,102 controls. RESULTS: In an overall analysis of 17,970 cases of ischemic stroke and 70,764 controls, we identified a novel association on chromosome 12q24 (rs10744777, odds ratio [OR] 1.10 [1.07-1.13], p = 7.12 × 10(-11)) with
o, if youre reading this, you are wondering about strokes. Either you, one of your parents or other loved one has had a stroke and you want answers. You may be a doctor and, like me you have been struck with the revelation that in the past 50 years we have made virtually no advances in either the immediate management of stroke victims or any impact on diminishing the long term deficits which so profoundly affect the lives of these patients and their families. Your questions could and, in fact, should include: "What causes a stroke?" "What kinds of strokes are there?" "How can I prevent a stroke?" "What happens in the Emergency Room when a new stroke patient is admitted?" "What should be done in the Emergency Room when a new stroke is admitted?" "What can be done if …. ...
In the United States, 795,000 people experience strokes annually (one stroke every 40 seconds).1 Of these events, 77% are primary strokes, whereas 23% represent recurrent strokes.1 In addition to the human costs, the financial implications of stroke are enormous-strokes accounted for an estimated $36.5 billion of total expenditures in the United States in 2010. Despite these grim statistics, from 2000 to 2010, the annual stroke death rate fell 35.8%.2 With the growing use of stroke units, thrombolysis, and other new therapies, there is increased hope for patients with acute stroke who present to the ED. ...
Stroke is one of the major causes of death and adult disability worldwide. The underlying pathophysiology of stroke is highly complicated, consisting of impairments of multiple signalling pathways, and numerous pathological processes such as acidosis, glutamate excitotoxicity, calcium overload, cerebral inflammation and reactive oxygen species (ROS) generation. The current treatment for ischemic stroke is limited to thromolytics such as recombinant tissue plasminogen activator (tPA). tPA has a very narrow therapeutic window, making it suitable to only a minority of stroke patients. Hence, there is great urgency to develop new therapies that can protect brain tissue from ischemic damage. Recent studies have shown that new vessel formation after stroke not only replenishes blood flow to the ischemic area of the brain, but also promotes neurogenesis and improves neurological functions in both animal models and patients. Therefore, drugs that can promote angiogenesis after ischemic stroke can provide
Patients with atrial fibrillation (AF) have an increased risk of ischemic stroke, transient ischemic attack (TIA), and systemic embolism compared with patients without AF (1). In patients with AF, several risk factors are well documented and included in risk scores used for risk stratification. These include advancing age, diabetes mellitus, hypertension, congestive heart disease, peripheral artery disease, and previous stroke/TIA, among others. Coronary artery disease (CAD) and ischemic stroke share several common risk factors, but whether CAD is an independent risk factor for ischemic stroke among patients with AF has not yet been examined. The aim of this study was to investigate whether the presence of CAD provided independent prognostic information of the risk of future ischemic stroke and thromboembolism in patients with AF.. The association between CAD and ischemic stroke risk was examined in a large, prospectively collected dataset of consecutive patients with AF who underwent coronary ...
We all know its smart to write down our symptoms before a visit to our healthcare provider, but most of us simply dont take the time. In many cases, it may be only subtle symptoms that trigger a proper diagnosis. This is certainly true when it comes to stroke. There are basically two types of stroke: hemorrhagic stroke and ischemic stroke. A ruptured aneurism, or a leak in an artery, can result in a hemorrhagic stroke while a blood clot that blocks an artery can give rise to an ischemic stroke. Both types often give immediate and obvious nervous system signs and symptoms that typically prompt a call for emergency services. There is however, a less common and quite subtle type of stroke that is far less discussed and understood. This is called vertebral-basilar insufficiency (VBI) stroke, which is caused by vertebral artery dissection (VAD). This type of stroke is very rare and only occurs 0.75-1.12 times per every 100,000 person years. In VAD/VBI, there may not be ANY history of trauma or ...
The disappointingly slow progress in developing effective therapies for ischemic stroke has led to a re-evaluation of the strategies for stroke drug development and the methods used in clinical trials. Magnetic resonance imaging (MRI) techniques have been proposed and have begun to be used in stroke trials as a means of optimizing patient selection and as a direct measure of the effect of treatments on the brain.. One objective in all clinical trials is the selection of a sample that is sufficiently homogeneous to reduce the statistical variance of the data and thereby optimize the sensitivity of the design to detecting a therapeutic response, while remaining representative of the population of interest. Ischemic stroke trials have traditionally sought to limit the range of disease studied according to one or more of several dimensions, such as clinical severity at the time of enrollment, exclusion of non-ischemic causes for the clinical syndrome, lesion location and vascular territory, stroke ...
HealthDay Reporter. (HealthDay News) -- It may not be for everyone, but a new study suggests that the smooth stride of a gentle horse may help stroke survivors regain lost mobility and balance years after their brain attack.. I dont think were ready to say that once youve reached the last phase of stroke recovery, you should get on a horse, said Dr. Daniel Lackland, a spokesperson for the American Stroke Association.. But, its exciting that many of these patients saw improvements with therapies outside of whats available in traditional stroke rehabilitation, he added.. None of the stroke survivors in the study had severe disabilities, but they did have lingering problems with essential functions like balance, walking and memory.. Researchers found that two unconventional therapies -- horseback riding and music-and-rhythm therapy -- seemed to help many of these patients.. Lackland also pointed to the bigger picture: The study showed that improvements can be made long after a stroke ...
THURSDAY, June 15, 2017 (HealthDay News) -- It may not be for everyone, but a new study suggests that the smooth stride of a gentle horse may help stroke survivors regain lost mobility and balance years after their brain attack.. "I dont think were ready to say that once youve reached the last phase of stroke recovery, you should get on a horse," said Dr. Daniel Lackland, a spokesperson for the American Stroke Association.. But, its "exciting" that many of these patients saw improvements with therapies "outside of whats available in traditional stroke rehabilitation," he added.. None of the stroke survivors in the study had severe disabilities, but they did have lingering problems with essential functions like balance, walking and memory.. Researchers found that two unconventional therapies -- horseback riding and music-and-rhythm therapy -- seemed to help many of these patients.. Lackland also pointed to the bigger picture: The study showed that improvements can be made long after a stroke ...
Background and aims: Early treatment is critical for successful intervention in acute stroke. The aim of this study was to describe delays in presentation to hospital and in the emergency department (ED) management of patients with acute stroke and to identify factors influencing these delays in an Italian urban hospital.. Methods: The present series includes all patients presenting with acute stroke, in whom arrival delay was ascertainable. To describe delays into the ED, the triage-visit delay, visit-computed tomography (CT) delay and visit-CT report delay were registered. Type of stroke, severity of stroke assessed using the modified National Institute of Health Stroke Scale (mNIHSS) scale, level of consciousness, history of previous stroke or previous hospital admission, use of the emergency medical service (EMS), onset of stroke during day or night and admission during working or non-working day were registered for every patient. Univariate and multivariate analysis were performed to ...