Abstract: Recurrent aphthous stomatitis (RAS) is known as the most common chronic disease of the oral cavity, which affects a range of 5-25% of the population. RAS appears to be associated with some human leukocyte antigen (HLA) class II alleles and haplotypes. This study attempts to survey the distribution of HLA-DRB and -DQB alleles among Iranian RAS patients and healthy controls. In order to evaluate the association of HLA-DR and DQ alleles and haplotypes, 54 patients with RAS and 100 unrelated healthy subjects as control group were investigated. Our data indicated that DRB1*13:17, DRB1*15:01, and DRB5*01 were significantly more frequent in RAS patients in comparison to controls. However, DRB3:01allele frequency was higher in the controls compared to the patients. The significantly frequent allele in the patients compared with the healthy subjects was HLA-DQB1*03:02. However, both HLA-DQB1*02:01 and HLA-DQB1*03:01 alleles were most frequent in the healthy individuals rather than the patients. ...
Objectives: Recurrent aphthous stomatitis (RAS) is a common inflammatory condition of unknown etiology, characterized by painful ulcers of the oral mucosa affecting 40% of the population. In a previous study (R03DE016356), certain dietary factors, particularly sugar, appeared to be associated with RAS. Thus, we hypothesized that sugar consumption would be highest in RAS cases and lowest in controls. Methods: Data were collected through standardized questionnaires, blood draw, and physical examinations, during an unmatched case-control study (June 2009-April 2011). Main eligibility criteria were: age ,12, at least 2 idiopathic RAS episodes in the 6 months prior to screening, fasting for ,5 hours, no smoking, alcohol, or certain medications in past 24 hrs. Questionnaire items included RAS history, stress, and diet in past 7 days. We compared the diet in active (RAS onset ,72 hours) and inactive subjects (no RAS in the 5 days before or after a visit) vs. controls. Data were stored in REDCap and ...
The aim of this systematic review was to assess a potential benefit of laser use in the treatment of recurrent aphthous stomatitis (RAS). The primary outcome variables were pain relief, duration of wound healing and reduction in episode frequency. A PICO approach was used as a search strategy in Med …
PRIMARY: To evaluate the effectiveness and safety of thalidomide for treatment of oral and esophageal aphthous ulcers (those unrelated to a known infection or malignancy) in patients with advanced HIV disease. To evaluate the effect of thalidomide on HIV load in this patient population. Per 06/28/94 amendment, to evaluate the effectiveness of thalidomide in preventing recurrences in patients whose aphthae completely heal at the end of acute treatment.. SECONDARY: To evaluate the effect of thalidomide on blood tumor necrosis factor (TNF) levels and to obtain pharmacokinetic data on the drug. Per 06/28/94 amendment, to evaluate the safety of thalidomide. Per 05/10/95 amendment, to explore in a substudy the effects of thalidomide on idiopathic genital aphthous ulcers in HIV-infected women.. Aphthous ulcers of the mouth or esophagus can interfere with eating, resulting in malnutrition and wasting. Thalidomide has been proposed as an effective therapy for severe forms of aphthous ulceration in AIDS ...
Methods In 2013, a cohort for chronic diseases and related risk factors was initiated by the Turkish Society of Internal Medicine. For this purpose, Avanos and Gülşehir counties, which have a 5-year migration rate of less than 10%, were selected among the county seats of the Central Anatolia Region of Turkey (Cappadocia region). The cohort consisted of subjects aged ≥18 years living in the relevant counties and it was targeted to reach whole adult population. Informed consents were obtained from the adults and 90% of whole adult population agreed to participate in the study. Photos showing oral aphthous were usedwhen applying the questionnaire for chronic diseases. Participants with and without oral aphthous ulcer were compared in terms of sociodemographic and medical characteristics. ...
Recurrent aphthous stomatitis (RAS) is a common oral disease with unknown molecular pathogenesis. Our preliminary microarray analysis revealed the altered expression of lncRNA Cancer Susceptibility Gene 2 (CASC2) in RAS. We therefore analyzed the role of CASC2 in RAS. In this study, plasma samples were obtained from RAS patients and healthy participants. Plasma levels of CASC2 were measured by RT-qPCR. Plasma levels of IL-6 and IL-18 were measured by enzyme-linked immunosorbent assay (ELISA). A follow-up study was performed to analyze the role of CASC2 in the recurrence of RAS. In the present study, we found that lncRNA Cancer Susceptibility Gene 2 (CASC2), as well as pro-inflammatory factors interleukin 6 (IL-6) and interleukin 18 (IL-18), were upregulated in plasma of RAS patients compared with healthy participants. Plasma levels of lncRNA CASC2 were positively correlated with plasma levels of IL-6 and IL-18 in RAS patients but not in healthy participants. Compared with pre-treatment levels, plasma
Recurrent aphthous ulcers (canker sores) may initially appear as erythematous, indurated papules that erode to form sharply circumscribed necrotic ulcers with a gray, fibrinous exudate and an erythema... more
Methods: Included were 30 RAS patients consecutively referred to our centers without any systemic diseases. The ulcers were examined in terms of size and number. Recurrence intervals were recorded by the patients. 1 U/0.002 mL enoxaparin was injected subcutaneously (3 mg). Injections were repeated once a week for 8 weeks. The patients were followed monthly for three months. To determine the level of pain, Visual Analogue Scale (VAS) from 0 to 10 was used. The data were statistically analyzed to determine the difference between the number, size, and pain using Wilcoxon test ...
Aphthous stomatitis is a common condition characterized by the repeated formation of benign and non-contagious mouth ulcers (aphthae) in otherwise healthy individuals. The informal term canker sores is also used, mainly in North America, although this may also refer to any mouth ulcer. The cause is not completely understood, but involves a T cell-mediated immune response triggered by a variety of factors. Different individuals have different triggers, which may include nutritional deficiencies, local trauma, stress, hormonal influences, allergies, or genetic predisposition. These ulcers occur periodically and heal completely between attacks. In the majority of cases, the individual ulcers last about 7-10 days, and ulceration episodes occur 3-6 times per year. Most appear on the non-keratinizing epithelial surfaces in the mouth (i.e. anywhere except the attached gingiva, the hard palate and the dorsum of the tongue), although the more severe forms, which are less common, may also involve ...
Learn about the causes, symptoms, diagnosis & treatment of Symptoms of Oral and Dental Disorders from the Home Version of the Merck Manuals.
Journal of Oral and Maxillofacial Pathology (JOMFP) is the official publication of the Indian Association of Oral and Maxillofacial Pathology, India
UCL Discovery is UCLs open access repository, showcasing and providing access to UCL research outputs from all UCL disciplines.
Aphthous Stomatitis is a specialized etiology of stomatitis or ulceration of the oral mucosa. The etiology is unknown but disease can be triggered by stress or reactivation of Inflammatory Bowel Disease ...
Usefulness of oral administration of the specialized amino acid supplement consisting of β-hydroxy-β-methylbutyrate, l-arginine and l-glutamine (Abound™) for chronic soft tissue diseases in the mouth. Aphthous stomatitis ...
There are several potential products on the market for OTC use. Such options include aloe vera, biologics, gamma globulin treatment, sodium chromoglycate lozenges, dapson, colchicine, pentoxifyllin, levamisol, colchicine, azathioprine, prednisolone, azelastin, alpha 2-interferon, cyclosporin, deglycerated licorice, 5-amino salicylic acid (5-ASA), prostaglandin E2 (PGE2), sucralfate, diclofenac and aspirin.. Apart from potent steroids, which cause problematic side effects, none of these drugs are accepted by the medical community as being consistently beneficial in the treatment of RAS. This is supported by a Cochrane review (2012) of treatments for aphthous stomatitis, which found that data from all major attempts lacked methodological rigor and concluded that no single therapy could be recommended given the data currently available.. Current status. We have established an innovation company (Mucocort AB) with multiple competences relevant to RAS. An IP/IA strategy is formulated and under ...
confused: Im 20 right now. doing my third year MBBS. since my childhood days i used to get repeated aphthous ulcers on and off.. when i got it for the first time, when i was a kid, my mom used to give me home treatment. since then, whenever i get aphthous ulcers, i used to follow that... but im not sure why i get this... I thought that it was due to b complex vitamin deficiency but i used to take it on and off... is there any suggetions about this ...
TY - JOUR. T1 - Epiglottic aphthous ulcers. AU - Hagiya, Hideharu. AU - Hanakawa, Hiroyuki. AU - Katsuyama, Takayuki. AU - Otsuka, Fumio. PY - 2014. Y1 - 2014. KW - Behçets disease. KW - Epiglottic aphthous ulcers. UR - http://www.scopus.com/inward/record.url?scp=84905233559&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=84905233559&partnerID=8YFLogxK. U2 - 10.2169/internalmedicine.53.2734. DO - 10.2169/internalmedicine.53.2734. M3 - Article. C2 - 25088901. AN - SCOPUS:84905233559. VL - 53. SP - 1731. JO - Internal Medicine. JF - Internal Medicine. SN - 0918-2918. IS - 15. ER - ...
Dear Dr. K: Dear Dr. K: I get recurrent aphthous ulcers in my mouth and on my tongue. Is this an allergic problem?. Known by various names, including canker sores, this condition of recurrent aphthous stomatitis (RAS) can be due to allergy, but that is one of the least frequent causes. Several systemic illnesses have RAS as part of their disease complex, including Behcets disease with RAS, genital ulcers, eye disease and neurologic symptoms; MAGIC syndrome with RAS, genital ulcers and inflamed cartilage; PFAPA syndrome with RAS, periodic fever and swollen lymph nodes; SWEET syndrome with RAS, periodic fever and significant skin rash, and Cyclic neutropenia with RAS, fever every 15 to 24 days and a low white blood count.. In terms of allergy, RAS is very rarely seen as a response to food allergy, but more commonly as an allergy to tooth paste - especially kinds that contain sodium lauryl sulfate. Very rarely it occurs from chewing gums that contain balsam of Peru.. Factors that predispose to, ...
Marshall, GS, Edwards, KM, Butler, J, Lawton, AR. "Syndrome of periodic fever, pharyngitis, and aphthous stomatitis". J Pediatr. vol. 110. 1987. pp. 43 Thomas, KT, Feder, HM, Lawton, AR, Edwards, KM. "Periodic fever syndrome in children". J Pediatr. vol. 135. 1999. pp. 15 Caorsi, R, Pelagatti, MA, Federici, S, Finetti, M, Martini, A, Gattorno, M. "Periodic fever, aphthous stomatitis, pharyngitis and adenitis syndrome". Curr Opin Rheumatol. vol. 22. 2010. pp. 579 Burton, MJ, Polard, AJ, Ramsden, JD. "Tonsillectomy for periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis syndrome (PFAPA)". Cochrance Database Syst Rev. 2010: Sep 8. Gattorno, M, Caorsi, R, Meini, A, Cattalini, M, Federici, S, Zulian, F. "Differentiating PFAPA syndrome from monogenic periodic fevers". Pediatrics. vol. 124. 2009. pp. e721 Caorsi, R, Pelagatti, MA, Federici, S, Finetti, M, Martini, A, Gattorno, M. "Periodic fever, apthous stomatitis, pharyngitis and adenitis syndrome". Curr Opin Rheumatol. vol. 22. ...
Author: Kimberly N. Powell, DDS, MS Aphthous mouth ulcers, known commonly as canker sores, can be very uncomfortable. Daily routines like eating, drinking, oral hygiene methods can cause pain. The cause of aphthous ulcers is unclear but can be triggered by stress, vitamin deficiency (B-12, zinc, folate, iron), food sensitivities, mouth trauma, hormonal changes, sodium lauryl sulfate found…
Amlexanox is an antiallergic drug, clinically effective for atopic diseases, especially allergic asthma and rhinitis. Amlexanox as a topical paste is a well tolerated treatment of recurrent aphthous ulcers. Recurrent aphthous ulcer (RAU) is the most prevalent oral mucosal disease in humans, estimated to affect between 5% and 50% of the general population.
Oral mucosal diseases include benign conditions, oral infections, immunologically- mediated conditions, potentially malignant disorders, and oral …
Aphthous stomatitis or mouth ulcers (aka canker sores) can be be a real pain in the ass, well, mouth - those 5-20% of people occasionally suffering from it know
Oral ulcerations are common. Oral ulcers can have a localised aetiology or be a manifestation of a variety of systemic conditions or disorders. Appropriate management depends on the correct diagnosis which can at times be difficult due to similar clinical features. The aetiology, diagnosis and management of the most common non-viral ulcerative disorders of the oral mucosa are discussed. These include traumatic ulcers, recurrent aphthous stomatitis, malignancy as well as oral ulceration associated with cutaneous pathology.
Looking for aphthous fever? Find out information about aphthous fever. or highly contagious disease almost exclusive to cattle, sheep, swine, goats, and other cloven-hoofed animals. It is caused by a virus, specifically an... Explanation of aphthous fever
Canker sores are common in adults and children, and generally tend to cause discomfort, particularly during eating. Although several factors have been named as possible causes of aphthous ulcers, trauma is the most common trigger for them. It has also been observed that they appear in patients who are under stress, or those experiencing health problems. They have also been attributed to hormonal changes, and to some types of dietary deficiencies (ie, Vitamin B12, Iron, Folic Acid, etc.). Although there is no specific treatment for the ulcer itself, except for severe cases (where usually steroids are prescribed); treatment is usually focused on the pain caused by the ulceration. ...
Aphthous ulcers are more commonly known as canker sores. These are small painful ulcers that typically cause bad breath and craters in the mouth but should not be confused as being a form of cancer. They are most often found under the tongue or on the inside lining of the cheeks or lips. Usually they heal within two weeks and they dont normally leave a permanent mark or scar. They are identified by their red tip but are mostly white or yellow. Twenty percent of people experience these at some point in time.. There are three main categories of these ulcers - minor, major and herpetiform. The first type is found on the soft palate and the floor of the mouth and they are generally small and rather shallow. The second type is larger and deeper than the minor while the herpetiform are more intense are appear in larger numbers than the others. Individuals who experience the last form should be tested for HIV because this condition is a main cause of herpetiform ulcers.. These sores are more commonly ...
The Autoinflammatory Alliance is a non-profit dedicated to increasing awareness, care and treatment for patients with Cryopyrin-Associated Periodic Syndromes, including: NOMID/CINCA, Muckle-Wells (MWS) Familial Cold Autoinflammatory Syndromes (FCAS), and other autoinflammatory diseases.
A study was done on the effects of bee propolis on Recurrent Aphthous Stomatitis (RAS) -- also known as canker sores -- at the Harvard School of Dental Medicine. Canker sores are an ulcerative disorder of the oral cavity. They have no cure and medicine used to prevent further outbreaks and relieve pain comes with its own set of dangerous side-effects. Bee propolis was evaluated as a potential remedy to reduce the number of mouth ulcer outbreaks. There were two groups of patients, one group who took a placebo capsule and the other group who took a propolis capsule. Patients who took the propolis capsule showed a significant decrease in the number of outbreaks of mouth ulcers. Another great effect of the propolis was that the patients reported a definite improvement in their quality of life. This would likely be due to the immune boosting effects that propolis has with its high levels of B-vitamin complex and notable quantities of vitamin C, E, and beta-carotene. ...
Periodic fever may be a challenging diagnostic problem and cause much anxiety. A relatively benign but extremely persistent form was described in Tennessee in 1987 and later given the acronym PFAPA (periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis). Now two reports in theJournal of Pediatrics have described 94 cases in America and 28 in Israel (Kenneth T Thomas and colleagues, 1999;135:15-21. Shai Padeh and colleagues,Ibid: 98-101. See also editorial by Sarah S Long, Ibid: 1-5). The condition usually affects preschool children with a slight preponderance of boys. A striking feature is regular periodicity with episodes lasting three to six days and recurring every four or five weeks for years. In the two series some 30-40% of the children followed up had stopped having attacks and the mean total duration of the illness in those children was 4.5 years in America and 8 years in Israel. Aphthous stomatitis, pharyngitis, and cervical lymphadenopathy are each present in some ...
Mediators of Inflammation is a peer-reviewed, Open Access journal that publishes original research and review articles on all types of inflammatory mediators, including cytokines, histamine, bradykinin, prostaglandins, leukotrienes, PAF, biological response modifiers and the family of cell adhesion-promoting molecules.
BACKGROUND: Stomatitis, the inflammation of mucous membranes lining the mouth and throat, is a frequent adverse event that is associated with the oral mTOR inhibitor everolimus and can significantly impact treatment adherence. Specific strategies to prevent and/or lessen the severity of everolimus-associated stomatitis are not well documented. Steroid mouthwashes and steroid gels or pastes used to treat recurrent aphthous stomatitis may be effective for stomatitis associated with everolimus. This phase 2, single-arm study will evaluate a steroid-based therapeutic intervention to prevent stomatitis (Grade ≥2) in breast cancer patients taking everolimus + exemestane.. METHODS: Eligible participants will be patients with HR-positive, HER2-negative advanced breast cancer with no evidence of oral stomatitis or other oral pathology who have been prescribed everolimus + exemestane but have not yet started treatment. A baseline oral assessment will be conducted, and patients will be provided ...
CDGF : Celiac disease (gluten-sensitive enteropathy, celiac sprue) results from an immune-mediated inflammatory process following ingestion of wheat, rye, or barley proteins that occurs in genetically susceptible individuals.(1) The inflammation in celiac disease occurs primarily in the mucosa of the small intestine, which leads to villous atrophy.(1) Common clinical manifestations related to gastrointestinal inflammation include abdominal pain, malabsorption, diarrhea, and constipation.(2) Clinical symptoms of celiac disease are not restricted to the gastrointestinal tract. Other common manifestations of celiac disease include failure to grow (delayed puberty and short stature), iron deficiency, recurrent fetal loss, osteoporosis, chronic fatigue, recurrent aphthous stomatitis (canker sores), dental enamel hypoplasia, and dermatitis herpetiformis.(3) Patients with celiac disease may also present with neuropsychiatric manifestations including ataxia and peripheral neuropathy, and are at increased risk
Celiac disease (gluten-sensitive enteropathy, celiac sprue) results from an immune-mediated inflammatory process that occurs in genetically susceptible individuals following ingestion of wheat, rye, or barley proteins.(1) The inflammation in celiac disease occurs primarily in the mucosa of the small intestine, which leads to villous atrophy.(1) Common clinical manifestations related to gastrointestinal inflammation include abdominal pain, malabsorption, diarrhea, and/or constipation.(2) Clinical symptoms of celiac disease are not restricted to the gastrointestinal tract. Other common manifestations of celiac disease include failure to grow (delayed puberty and short stature), iron deficiency, recurrent fetal loss, osteoporosis, chronic fatigue, recurrent aphthous stomatitis (canker sores), dental enamel hypoplasia, and dermatitis herpetiformis.(3) Patients with celiac disease may also present with neuropsychiatric manifestations including ataxia and peripheral neuropathy, and are at increased ...
Debacterol Canker Sore Pain Relief solution is a liquid topical agent that is used in the treatment of ulcerating oral mucosal lesions and minor oral abrasions. Debacterol is used in the treatment of recurrent aphthous stomatitis (canker sores). Debacterol usually comes in a swab form, but is also available in a vial. One clinical trial comparing Debacterol to Kenalog-in-Orabase and a no-intervention control group found that patients treated with Debacterol reported significantly better relief of symptoms compared to the other two groups 3 days after treatment. In the same study, 60% of ulcers treated with Debacterol had disappeared by day 6 compared to about 30% in the other groups. Debacterol appears to be more effective on mouth sores in areas of the mouth which have less saliva production. Since a mouth sore must be dry prior to application of Debacterol, the area under the tongue is difficult to get a solid application on. The length of time of pain relief and the overall effectiveness may ...
Recurrent aphthous stomatitis (RAS) is the most common oral ulcerative inflammatory disease with unknown etiology. IL-2 and IFN-γ are secreted by Th1 cells and the elevated levels of them have been reported in RAS. Single nucleotide polymorphisms (SNPs) of IL-2 and IFN-γ genes could alter the cytokine production. The aim of this study was to investigate frequencies of IL-2 and IFN-γ alleles and genotypes in a group of patients with minor-RAS (MiRAS). PCR-SSP method used to type genomic DNA of 64 Iranian patients with MiRAS for IL-2 gene (G -330 T) and (G +166 T) and IFN-γ gene at position UTR5644 (A/T ...
PMID 19624767] Influence of inducible nitric oxide synthase polymorphisms in Japanese patients with non-alcoholic fatty liver disease [PMID 21481004] Association between recurrent aphthous stomatitis and inheritance of a single-nucleotide polymorphism of the NOS2 gene encoding inducible nitric oxide synthase. ...
BACKGROUND: Recurrent fever syndrome, known as the Marshall syndrome (MS), is a clinical entity that includes several clinical features, such as: fever (39-40°C) that occurs repeatedly at variable intervals (3-8 weeks) and in episodes of 3 to 6 days, cervical adenopathy, pharyngitis, and aphthous stomatitis. The diagnosis of MS is one of exclusions; laboratory data is nonspecific and no abnormalities correlated with MS have been detected thus far. METHODS: The authors report the case of a 2-year-old girl admitted to a tertiary pediatric center for repeated episodes of fever with aphthous stomatitis and laterocervical adenopathy ...
That B*tch has photos of Rihanna hiding her mouth from the paps - and for good read reason. She has a canker sore (otherwise known as an Aphthous ulcer) on her lip and she doesnt want you to see it.. Canker sores can be rather unsightly and distressing, particularly to women like RiRi who rely on their looks for their livelihood.. Now the messy ones among us want you to believe she has Herpes Simplex (a cold sore). But I doubt it.. An Aphthous ulcer is a very common, recurrent skin condition that is not contagious like Herpes or MRSA. Almost 10% of the population suffers from Aphthous ulcers - mostly women. The cause is unknown.. If Rihanna does have Herpes, we wonder where she got it?. Looks like Chris is wondering too.. ...
to the editor: Years ago I learned from my father, who was also a physician, a simple and highly effective way to manage aphthous ulcers-touch them with a silver nitrate stick. Obviously, one needs to be sure there is no other apparent etiology but, because the most common cause is not related to underlying disease, the silver nitrate stick works wonders, and patients walk out of the office pain free.. The procedure is simple: wet the tip of the stick and gently touch it to the ulcer. When the ulcer turns white, remove the stick. Have patients swish out the silver nitrate and send them home. You should warn them that the procedure may sting for a moment but, considering that they are already in pain, they dont really notice much difference. Although silver nitrate cautery may cause more tissue necrosis and longer healing time if it is left in place too long, I have not found this to be a problem. ...
Aphthous stomatitis, commonly referred to as canker sores, is the most common form of oral ulcerative disease, but its cause is still uncertain. Aphthous ulcers can range from minor to severe in pain and occur in otherwise healthy patients. Etiologic factors such as stress, physical or chemical trauma, food sensitivity and infection related to Helicobacter pylori and herpes simplex virus have been investigated, but no consistent link has been determined.This has led to treatments that focus on symptom reduction, including: … Continued. ...
Mouth Ulcers Drugs Market by Indications (Aphthous Stomatitis, Oral Lichen Planus), Drug Classes (Analgesic, Anesthetic, Antihistamine, Antimicrobial, and Corticosteroids), and Formulation Types (Gel,...
Canker sores, also called mouth ulcers and mouth sores by most people, and aphthous ulcers or recurrent aphthous stomatitus by doctors and scientists, are little painful crater-like sores that develop in the mouths of susceptible people. They...
The syndrome has three common manifestations; painful aphthous ulcers of the mouth, ulcers on the genitals, and inflammation of the inner tissues of the eyes. Aphthous ulcers of the mouth, which we commonly call canker sores, are very common, most people have had them at some time, and obviously not everyone who has had a canker sore develops Behcets. The criteria for making the diagnosis include recurrent ulcers of the mouth plus at least two of the following: recurrent genital ulcers, inflammation in the eye, skin lesions called erythema nodosum, or a positive skin test.. The diagnosis can be tricky, as many people have oral ulcers, the genital ulcers can be mistaken for genital herpes or syphilis, and the other criteria can also be seen in different conditions. The disease can also produce arthritis, a type of meningitis or brain involvement, and sometimes intestinal symptoms.. Our writer today does not mention which manifestations of Behcets she has, but she is clearly in pain a lot, and ...
People with celiac disease may have no symptoms other than oral and dental abnormalities, such as enamel defects and recurrent aphthous ulcers. Thus, dentists and hygienists have an important role to play in identification of these patients.
A 58-year-old man with a history of recurrent aphthous ulcers since childhood was admitted to the hospital with acute neurological decline characterised by loss of motor dexterity, dysarthria, dysphagia and unsteady gait. MRI brain was significant for symmetrical hyperintense T2 fluid attenuated inversion recovery (FLAIR) in the corticospinal tracts, including parts of the pons and the mesodiencephalic junction. Though initial concern was for neuro-Behçets disease, brain biopsy ultimately revealed a diagnosis of astrocytoma. This report demonstrates a mimic of neuro-Behçets disease and the importance of confirming the correct diagnosis prior to initiating therapy. ...
Primary immunodeficiencies with selective susceptibility to EBV infection are rare conditions associated with severe lymphoproliferation. We followed a patient, son of consanguineous parents, referred to our centre for recurrent periodic episodes of fever associated with tonsillitis and adenitis started after an infectious mononucleosis and responsive to oral steroid. An initial diagnosis of periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis (PFAPA) syndrome was made. In the following months recurrent respiratory infections and episodes of keratitis were also observed, together with a progressive reduction of immunoglobulin levels and an increase of CD20+ cells. Cell sorting and EBV PCR showed 25000 copies for 100000 leucocytes with predominant infection of B lymphocytes. Lymph nodes biopsy revealed reactive lymphadenopathy with paracortical involvement consistent with a chronic EBV infection. Molecular analysis of XIAP, SHA2D1A, ITK, and CD27 genes did not detect any pathogenic
Intractable ulcerating enterocolitis is an uncommon inflammatory bowel disease syndrome of neonatal onset first described in 1991. Intractable ulcerating enterocolitis usually presents in the neonate with a mouth ulceration and the subsequent development of perianal disease and colitis.. In this case report, an infant, 18 days from birth, with ulcerative lesion on hard palate for systemic differential diagnosis about oral lesion is referred from the department depiatrics. At that time, there is no abnormality, except oral lesion-like Aphthous ulcer. The patient was discharged from pediatrics, but returned to the hospital 3weeks later with blood diarrhea. As a result of endoscopy, there were large ulcerating lesions and the patient was diagnosed intractable ulcerating enterocolitis.. Early recognition of Intractable ulcerating enterocolitis appears to be beneficial because colectomy, as opposed to immunosuppression, appears to be effective in controlling disease symptoms and progression. Most of ...
PFAPA has recently been defined as a non-hereditary autoinflammatory disease characterized by Periodic episodes of high Fever, Aphthous stomatitis, Pharyngitis and cervical Adenitis. PFAPA is a benign pediatric syndrome of unknown etiology. It might have been diagnosed as antibiotic-resistant recurrent tonsillitis and indicated for unnecessary tonsillectomy in the otolaryngology clinic. Autoinflammatory diseases are a new and expanding classification of inflammatory diseases characterized by recurrent episodes of systemic inflammation in the absence of pathogens, autoantibodies or antigen-specific T cells. This disease is induced by abnormality of neutrophil-related inflammatory cytokines that regulates inflammation, innate immunity and apoptosis. Up-to-date information on innate immunity is also concisely reviewed.. ...
Dear Doctor Ninja,. I recently had my annual physical where I told my physician about my endless battle with canker sores. To figure out what was going on we did some basic blood work and found out that I have a deficiency in Vitamin B12. Ive been taking over the counter B12 supplements for about 6 weeks now, but my canker sores are still just as prevalent as before. My question is really a few questions. How long does it take for oral, over the counter supplements to kick in to fix this kind of issue? Would the B12 shots be a better option for this? And finally, do supplements really fix this kind of issue to begin with, or is it just a way to cover up some low blood test results? Signed,. Cankered Out. There is one trial examining how effective vitamin B12 is at reducing both how long canker sores last as well as how often people get them. This study showed a dramatic reduction in both how long sores lasted as well as the number of sores per month, with an average starting rate of 27.6 sores ...