A naturally produced molecule called resveratrol, found in the skin of red grapes, has been shown to lower insulin levels in mice when injected directly into the brain, even when the animals ate a high-fat diet.. The findings from a new UT Southwestern Medical Center study suggest that when acting directly on certain proteins in the brain, resveratrol may offer some protection against diabetes. Prior research has shown that the compound exerts anti-diabetic actions when given orally to animals with type 2 diabetes (non-insulin dependent diabetes mellitus), but it has been unclear which tissues in the body mediated these effects.. "Our study shows that the brain plays an important role in mediating resveratrols anti-diabetic actions, and it does so independent of changes in food intake and body weight," said Dr. Roberto Coppari, assistant professor of internal medicine at UT Southwestern and senior author of the study appearing online and in the December issue of Endocrinology.. "These animals ...
Resveratrol in high doses has been shown to extend lifespan in some studies in invertebrates and to prevent early mortality in mice fed a high-fat diet. We fed mice from middle age (14-months) to old age (30-months) either a control diet, a low dose of resveratrol (4.9 mg kg−1 day−1), or a calorie restricted (CR) diet and examined genome-wide transcriptional profiles. We report a striking transcriptional overlap of CR and resveratrol in heart, skeletal muscle and brain. Both dietary interventions inhibit gene expression profiles associated with cardiac and skeletal muscle aging, and prevent age-related cardiac dysfunction. Dietary resveratrol also mimics the effects of CR in insulin mediated glucose uptake in muscle. Gene expression profiling suggests that both CR and resveratrol may retard some aspects of aging through alterations in chromatin structure and transcription. Resveratrol, at doses that can be readily achieved in humans, fulfills the definition of a dietary compound that mimics some
Effects of Dietary Resveratrol on Growth Performance, Blood Biochemical Parameter, Immunoglobulin, and Blood Antioxidant Activity in Broiler Chicks - resveratrol;broiler;blood biochemical parameter;immunoglobulin;blood antioxidant activity;
In 1997, Jang and collegues published a seminar paper reporting the ability of resveratrol to inhibit skin carcinogenesis at multiple stages. Since then, systemic administration of resveratrol has been shown to inhibit the initiation of growth of tumors in a wide variety of rodent cancer models. The fficacy of low doses (200 ug per kg body weight daily in a rat model of colon carcinogenesis suggests that even the concentration of resveratrol obtained from dietary sources, such as red wine, could be therapeutic in some cases. At higher, but pharmacologically achievable doses, the protective effects of resveratrol are even more dramatic in many cancer models. Resveratrol can inhibit cyclooxgygenase to reduce the risk of developing many cancers. Resveratrol can also inhibit tumor-induced neovascularization at a dose of 2.5-100 mg per kg of body weight. Another mechanism for resveratrol to inhibit tumor formation is to induce cell cycle arrest and apoptosis possibly through the induction of caspase 3 ...
Researchers believe resveratrol may help promote eye health including prevention of glaucoma, cataracts and macular degeneration.
Grape Ingredient Resveratrol Increases Beneficial Fat Hormone. ScienceDaily - Resveratrol, a compound in grapes, displays antioxidant and other positive properties. In a study published this week, researchers at the UT Health Science Center San Antonio describe a novel way in which resveratrol exerts these beneficial health effects.. Resveratrol stimulates the expression of adiponectin, a hormone derived from cells that manufacture and store fat, the team found. Adiponectin has a wide range of beneficial effects on obesity-related medical complications, said senior author Feng Liu, Ph.D., professor of pharmacology and member of the Barshop Institute of Longevity and Aging Studies at the Health Science Center.. Both adiponectin and resveratrol display anti-obesity, anti-insulin resistance and anti-aging properties ...
Introduction. Antioxidant properties of resveratrol have been intensively studied for the last years, both in vivo and in vitro. Its bioavailability after an oral dose is very low and therefore it is very important to make sure that plasma concentrations of free resveratrol are sufficient enough to be active as antioxidant. Aims. In the present study, using nutritionally relevant concentrations of resveratrol, we aim to confirm its antioxidant capacity on reducing peroxide levels and look for the molecular pathway involved in this antioxidant effect. Methods. We used mammary gland tumor cells (MCF-7), which were pretreated with different concentrations of resveratrol for 48 h, and/or a PTEN inhibitor (bpV: bipy). Hydrogen peroxide levels were determined by fluorimetry, PTEN levels and Akt phosphorylation by Western Blotting, and mRNA expression of antioxidant genes by real-time reverse transcriptase-polymerase chain reaction (RT-PCR). Results. Resveratrol treatment for 48 h lowered peroxide ...
The correlation of c-Myc expression with resveratrol-induced turnover of medulloblastoma cells was investigated in this study by checking (1) c-Myc expression in medulloblastoma tissues and cell lines (UW228-2 and UW228-3), (2) the in vitro effect of resveratrol on c-Myc expression and (3) the influences of c-Myc inhibition in cell growth and survival. Immunohistochemical staining of human medulloblastomas and noncancerous cerebellar tissues revealed that 8 out of 11 tumor tissues (72.7%) expressed c-Myc, in which 4 cases (50%) showed intensified nuclear labeling. RT-PCR, Western blotting, immunocytochemical and immunofluorescence stainings revealed c-Myc downregulation accompanied with growth suppression and apoptosis. Flow cytometry analysis showed S phase arrest in resveratrol-treated cell populations. Transfection of c-Myc directed antisense oligonucleotides to the cultured medulloblastoma cells could reduce c-Myc expression, inhibit cell growth and arrest the cell cycle at S phase. Our ...
Sirtuin 1 (SIRT1) is a protein deacetylases that is involved in regulation of cell metabolism, stress response and aging. Resveratrol, a polyphenol found in wines, it has been described as a potent activator of SIRT1 enzyme. Several studies have shown that resveratrol treatment can prevent progression of wide variety of age-associated diseases, including the pulmonary diseases. Therefore, we aim to investigate the mechanism by which SIRT1 might regulate the development and progression of lung fibrosis.. Bleomycin-treated mice were gavaged with saline or with resveratrol daily. At the day 14 all mice were sacrificed, lung function was measured and lung tissues were excised and processed for further analysis. The results have shown increased survival rate of resveratrol-treated animals, as well as significantly improved lung function. Resveratrol treatment markedly reduced levels of fibrotic markers such as fibronectin, collagen I and collagen IV. Furthermore, our data have demonstrated that ...
Resveratrol (3,4,5-trihydroxystilbene) belongs to a class of polyphenolic compounds called stilbenes (1). Some types of plants produce resveratrol and other stilbenes in response to stress, injury, fungal infection, and ultraviolet (UV) radiation (2). Resveratrol is a fat-soluble compound that occurs in a trans and a cis configuration (see figure 1). Both cis- and trans-resveratrol also occur as glucosides (bound to a glucose molecule). Resveratrol-3-O-beta-glucoside is also called piceid (3). Scientists became interested in exploring potential health benefits of resveratrol in 1992 when its presence was first reported in red wine (4), leading to speculation that resveratrol might help explain the "French Paradox" (see Cardiovascular Disease below). More recently, reports on the potential for resveratrol to inhibit the development of cancer (5) and extend lifespan (6) in cell culture and animal models have continued to generate scientific interest.. Summary. * Resveratrol is a polyphenolic ...
This page contains the abstract- A Low Dose of Dietary Resveratrol Partially Mimics Caloric Restriction and Retards Aging Parameters in Mice http://www.chiro.org/nutrition/ABSTRACTS/A_Low_Dose_of_Dietary_Resveratrol.shtml
Resveratrol (3,4,5-trihydroxy-trans-stilbene) is a secondary plant metabolite which is highly abundant in red grape skin and red wine [1]. Other dietary sources of resveratrol comprise berries, and peanuts [2, 3]. Although controversially discussed it has been recently shown that resveratrol may increase life span in model organisms such as Caenorhabditis elegans and Drosophila melanogaster [4-6]. The underlying mechanisms by which resveratrol may mediate beneficial effects have yet not been fully understood and may be partly related to its ability to induce phase II and antioxidant enzymes including heme oxygenase-1 and paraoxonase-1.. Heme oxygenase-1 (HO-1), is an inducible enzyme that catalyzes the rate-limiting step in the oxidative degradation of cellular heme that liberates iron, carbon monoxide (CO), and biliverdin. HO-1 exhibits antioxidant, anti-inflammatory and other cytoprotective functions [7].. Paraoxonase-1 (PON1) is a HDL associated serum enzyme which is mainly synthesized in ...
Resveratrol is a polyphenol naturally found in nuts, berries, and the skin of grapes, although in low concentrations. It possesses antioxidant and anti-inflammatory properties, with studies demonstrating its potential cardiovascular, anti-carcinogenic, and anti-aging benefits. Research has also shown significant benefits in several chronic inflammatory disorders.. According to a study published earlier this week in the Journal of Bone and Mineral Research, researchers investigated the effect of resveratrol supplementation on bone health in postmenopausal women. Resveratrol is also a phytoestrogen and animal studies have shown that it promotes osteoblastic formation similar to genistein. There have only been a few human studies investigating this; however, none of these studies were over six months in duration and none focused on postmenopausal women. This new study was a 24-month randomized, double-blind, placebo-controlled, two-period crossover study that included 125 postmenopausal women ...
Researchers demonstrate, for the first time that inhaled resveratrol treatments slow aging-related degenerative changes in mouse lung. Lung aging, characterized by airspace enlargement and decreasing lung function, is a significant risk factor for chronic human lung diseases.
This page contains the abstract- Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans http://www.chiro.org/nutrition/ABSTRACTS/Calorie_Restriction-like_Effects.shtml
Resveratrol possesses several beneficial metabolic effects in rodents, while the effects of resveratrol in humans remain unclear. Therefore, we performed a non-targeted comprehensive metabolomic analysis on blood, urine, adipose tissue, and skeletal muscle tissue in middle-aged men with metabolic syndrome randomized to either resveratrol or placebo treatment for four months. Changes in steroid hormones across all four matrices were the most pronounced changes observed. Resveratrol treatment reduced sulfated androgen precursors in blood, adipose tissue, and muscle tissue, and increased these metabolites in urine. Furthermore, markers of muscle turnover were increased and lipid metabolism was affected, with increased intracellular glycerol and accumulation of long-chain saturated, monounsaturated, and polyunsaturated (n3 and n6) free fatty acids in resveratrol-treated men. Finally, urinary derivatives of aromatic amino acids, which mainly reflect the composition of the gut microbiota, were altered upon
Sigma-Aldrich offers abstracts and full-text articles by [Shuang Zhou, Meng-Tao Li, Yu-Yan Jia, Jin-Jing Liu, Qian Wang, Zhuang Tian, Yong-Tai Liu, Hou-Zao Chen, De-Pei Liu, Xiao-Feng Zeng].
Oxidative DNA modifications such as 7,8-dihydro-8-oxoguanine (8-oxoG) are generated endogenously in apparently all living cells. The defect of the repair of 8-oxoG in Csbm/mOgg1−/− mice results in elevated basal levels of these lesions and increased frequencies of spontaneous mutations, which initiate tumorigenesis in the liver if cell proliferation is stimulated. Here, we describe that the phytoalexin resveratrol, applied either for 7 days per gavage (100 mg/kg body wt) or for 3-9 months in the diet (0.04% ad libitum), reduces the endogenous oxidative DNA base damage in the livers of the Csbm/mOgg1−/− mice by 20-30% (P , 0.01). A small but consistent effect is also observed in the wild-type animals. The spontaneous mutation frequencies determined in the lacI gene of BigBlue® Csbm/mOgg1−/− mice are concomitantly reduced by resveratrol to similar extents. Mechanistically, the protection is caused by an induction of the antioxidant defense system since (i) hepatocytes isolated from ...
Resveratrol inhibits benzo[a]pyrene-DNA adduct formation in human bronchial epithelial cells Resveratrol (trans-3,4,5-trihydroxystilbene), a phytoalexin present in various plants and foods, has in several in vitro and in vivo studies demonstrated cancer chemopreventive and chemotherapeutic potential. We investigated the in vitro effect of resveratrol on benzo[a]pyrene (B[a]P) -induced DNA adducts in human bronchial epithelial cells. This was compared to the effect of resveratrol on the expression of the cytochrome P450 (CYP) genes CYP1A1 and CYP1B1 and the formation of B[a]P metabolites. Exposure of BEAS-2B and BEP2D cells to B[a]P and increasing concentrations of resveratrol resulted in a dose- and time-dependent inhibition of DNA adduct formation quantified by (32)P-postlabelling. Supporting this result, resveratrol was shown to inhibit CYP1A1 and CYP1B1 gene expression, as measured by real-time reverse transcriptase-polymerase chain reaction. Also, a significant correlation was found between ...
If youve been diagnosed with breast cancer, you will surely want to look into every possible resource for treatment, and natural avenues like the resveratrol breast cancer remedy should not be overlooked. Resveratrol is an antioxidant found in grapes and in grape products like grape seed extract and red wine. There are many reported resveratrol health benefits, including improved heart function and weight loss, but some of resveratrols most promising uses center around cancer prevention and treatment. Resveratrol may be helpful in combating your breast cancer. Read this review if youd like to know more about the resveratrol breast cancer remedies:. - One of the major risk factors for breast cancer is prolonged exposure to the estrogen hormone. If a bodys estrogen processing system gets out of balance, dangerous estrogen metabolites start to appear. These metabolites react with the bodys DNA and trigger tumor growths like metastatic breast carcinoma. Resveratrol works by restricting the ...
.LongDesc { font-family: Verdana, Helvetica, Arial, sans-serif; font-size: 14px; font-style: normal; font-weight: normal; font-variant: normal; color: #666; } Now Natural Resveratrol - 16 fl. oz. Liquid Concentrate Blended with Acai, Mangosteen, Pomegranate, Goji Berry, VitaBerry plus other Super Fruits Free Radical Scavenger* A Dietary Supplement Vegetarian/Vegan Resveratrol is a polyphenol naturally found in the skin of red grapes, certain berries, and other plants. Recent research has shown that Resveratrol can support healthy cardiovascular function through its ability to quench reactive oxygen species, as well as through its ability to promote a healthy response to biological stress. NOW Resveratrol Liquid Concentrate also has Proanthocyanidins (OPCs) from Grape Seed Extract, Vitaberry, Acai, Cranberry and Pomegranate which naturally complement Resveratrols cellular and cardiovascular supporting properties. Suggested Usage: Shake well before using. As
TY - ABST. T1 - Preparative-scale isolation of resveratrol metabolites from human urine after oral intake of a resveratrol-containing dietary supplement. AU - Radko, Yulia AU - Christensen, Kathrine Bisgaard. AU - Christensen, Lars Porskjær PY - 2013. Y1 - 2013. U2 - 10.1055/s-0033-1348805. DO - 10.1055/s-0033-1348805. M3 - Conference abstract in journal. VL - 79. SP - PP6. JO - Planta Medica. JF - Planta Medica. SN - 0032-0943. IS - 10. ER - ...
The natural polyphenolic compound resveratrol, found in red wine, dark chocolate, and peanuts, may confer health benefits in humans. It is a powerful antioxidant that has been suggested to alleviate age-related pathologies, such as type II diabetes, neurodegenerative disorders, cardiovascular diseas...
Resveratrol (3,5,4′-trihydroxystilbene, RSV) is a natural potential anti-aging polyphenolic compound frequently used as a nutritional supplement against several diseases. However, the underlying mechanisms by which resveratrol regulates postovulatory aging of oocytes are still insufficiently known. In this study, we found that resveratrol could delay postovulatory aging and improve developmental competence of oocytes through activating selective mitophagy in the mouse. Resveratrol could maintain spindle morphology but it disturbed cortical granule (CG) distribution during oocyte aging. This might be due to upregulated mitophagy, since blocking mitophagy by cyclosporin A (CsA) treatment affected oocyte quality by damaging mitochondrial function and it decreased embryonic development. In addition, we also observed an involvement of FoxO3a in regulating mitophagy in aging oocytes following resveratrol treatment. Taken together, our results provide evidence that mitophagy induced by resveratrol is a
Resveratrol (3,5,4′-trihydroxystilbene, RSV) is a natural potential anti-aging polyphenolic compound frequently used as a nutritional supplement against several diseases. However, the underlying mechanisms by which resveratrol regulates postovulatory aging of oocytes are still insufficiently known. In this study, we found that resveratrol could delay postovulatory aging and improve developmental competence of oocytes through activating selective mitophagy in the mouse. Resveratrol could maintain spindle morphology but it disturbed cortical granule (CG) distribution during oocyte aging. This might be due to upregulated mitophagy, since blocking mitophagy by cyclosporin A (CsA) treatment affected oocyte quality by damaging mitochondrial function and it decreased embryonic development. In addition, we also observed an involvement of FoxO3a in regulating mitophagy in aging oocytes following resveratrol treatment. Taken together, our results provide evidence that mitophagy induced by resveratrol is a
Polycystic ovary syndrome (PCOS) is characterized by enlarged ovaries, menstrual irregularity and hyperandrogenism and is the most common cause of oligoovulatory infertility. Insulin resistance with resulting hyperinsulinemia is also common among women with PCOS, along with increased risk for dyslipidemia, hypertension, diabetes and related cardiovascular consequences. Resveratrol is a natural polyphenol with anti-carcinogenic, anti-proliferative and pro-apoptotic properties, that has been shown to decrease proliferation and steroidogenesis in theca cells, emerging as a potential therapeutic agent in PCOS patients. However, little is known about its potential beneficial effect on oocyte quality as well as other reproductive outcomes, such as implantation an pregnancy rates. The present study evaluates effects of resveratrol on selected biochemical parameters and reproductive outcome among patients with PCOS who undergo in vitro fertilization (IVF ...
Epidemiological studies have shown that the regular consumption of red wine may in part account for the apparent compatibility of a high fat diet with a low incidence of coronary atherosclerosis. This phenomenon, commonly referred to as the French paradox, may be associated with red wine constituents that exhibit tumor-preventive properties as well as inhibit reactions that increase the risk of coronary heart disease. Here we show that resveratrol, a polyphenol in red wine, induces nitric oxide synthase, the enzyme responsible for the biosynthesis of NO, in cultured pulmonary artery endothelial cells, suggesting that resveratrol could afford cardioprotection by affecting the expression of nitric oxide synthase. We also show that resveratrol inhibits the proliferation of pulmonary artery endothelial cells, which, based on flow cytometric analysis, correlates with the suppression of cell progression through S and G2 phases of the cell cycle. Western blot analysis and immunocytochemical protein ...
To determine whether resveratrol, a natural plant-derived drug, has protective effects against antibody-induced apoptosis of retinal cells in vitro and to provide insights on the mechanism of resveratrol protection. E1A.NR3 retinal cells pretreated with 40 μM resveratrol were grown in the presence of anti-recoverin (Rec-1), anti-enolase (Enol-1) antibodies, and normal purified immunoglobulins. When the cells were exposed to resveratrol before treatment with Enol-1 or Rec-1 antibodies, 30-55% more cells survived compared to the resveratrol-untreated cells. Western blotting showed a reduction in proapoptotic protein Bax in the cytoplasm and mitochondria of resveratrol-treated cells. Resveratrol-pretreated cells also showed a significant decrease in intracellular calcium and an inhibition of caspase-3 activity as compared to the untreated cells. Sirt1 expression was greatly reduced in the cells grown in the presence of Rec-1 and Enol-1, but it increased about five times in the resveratrol-pretreated cells
In the new study, researchers conducted a number of experiments in mice to determine whether the protective effect of resveratrol against atherosclerosis was related to changes in the gut microbiome. They found that resveratrol reduces levels of trimethylamine-N-oxide (TMAO), a known contributor to the development of atherosclerosis. They also found that resveratrol inhibits TMA production by gut bacteria; TMA is necessary for the production of TMAO.. "In our current study, we found that resveratrol can remodel the gut microbiota including increasing the Bacteroidetes-to-Firmicutes ratios, significantly inhibiting the growth of Prevotella, and increasing the relative abundance of Bacteroides, Lactobacillus, Bifidobacterium, and Akkermansia in mice," said Dr. Mi. "Resveratrol reduces TMAO levels by inhibiting the gut microbial TMA formation via remodeling gut microbiota.". According to Dr. Mi, the results suggest that a natural polyphenol without any side effects could be used as a treatment for ...
This is an important finding in a new paper published in the journal Science Translational Medicine by Cancer Research UK-funded researchers at the University of Leicesters Department of Cancer Studies and Molecular Medicine.. The paper reveals that resveratrol - a compound extracted from the skins of red grapes - is not rendered ineffective once it is metabolised by the body.. This is an important development, as resveratrol is metabolised very quickly - and it had previously been thought that levels of the extracted chemical drop too quickly to make it usable in clinical trials.. The new research shows that the chemical can still be taken into cells after it has been metabolised into resveratrol sulfates.. Enzymes within cells are then able to break it down into resveratrol again - meaning that levels of resveratrol in the cells are higher than was previously thought.. In fact, the results appear to show resveratrol may be more effective once it has been generated from resveratrol sulfate ...
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Researchers from the University of Texas found that the antioxidant compound resveratrol stimulates the expression of adiponectin - a hormone released from fat cells, which plays an important role in the regulation of insulin sensitivity and energy The new study, published in the Journal of Biological Chemistry, reports that resveratrol stimulates the expression and protein clustering (multimerization) of adiponectin in specialized fat cells through the activation of a protein known as disulfide bond-A oxidoreductase- like protein (DsbA-L). "Our study uncovers a novel mechanism by which resveratrol exerts its health beneficial effect," said senior author Dr Feng Liu, professor of pharmacology at UT. "The results from these studies should be of interest to those who are obese, diabetic and growing older," he added. They said the finding that resveratrol promotes adiponectin expression provides a novel mechanism by which resveratrol exerts its health beneficial functions. Anti-oxidant Resveratrol ...
In the current study, we found that the polar body rate, an index of the nucleus maturation of porcine oocytes, was retarded by heat stress. Resveratrol (2.0 μmol/L) relieved the adverse effect and increased the proportion of oocytes that had matured into the MII stage (Fig. 1a). This effect of resveratrol may attribute its ability to be an antioxidant. Resveratrol has a strong capacity to reduce oxidant damage [29]. It improves the maturation environment by alleviating the high level of ROS in heat-treated porcine oocytes. Our results confirmed that resveratrol (2.0 μmol/L) not only scavenged ROS but also improved the intracellular GSH level of oocytes to further fight oxidative stress (Fig. 2b-c). This finding was consistent with the result of Kwak et al. [25]. These authors reported that resveratrol failed to increase the polar body rate of porcine oocytes in the normal case. However, our data showed that resveratrol (2.0 μmol/L) improved nuclear maturation, which indicated resveratrol had ...
Most research on resveratrol has been done on animals, not people. Research in mice given resveratrol suggests that the antioxidant might also help protect them from obesity and diabetes, both of which are strong risk factors for heart disease. However, those findings were reported only in mice, not in people. In addition, to get the same dose of resveratrol used in the mice studies, a person would have to drink more than 1,000 liters of red wine every day. Research in pigs has shown that resveratrol may improve heart function and increase the bodys ability to use insulin. Again, however, these benefits have not been tested in people ...
Resveratrol, a polyphenolic compound, is a naturally occurring phytochemical and is found in a variety of plants, including food such as grapes, berries and peanuts. It has gained much attention for its potential anticancer activity against various types of human cancer. However, the usefulness of resveratrol as a chemotherapeutic agent is limited by its photosensitivity and metabolic instability. In this study the effects of a synthetic analogue of resveratrol, HS-1793, on the proliferation and apoptotic cell death were investigated using MCF-7 (wild-type p53) and MDA-MB-231 (mutant p53) human breast cancer cells. HS-1793 inhibited cell growth and induced apoptotic cell death in a concentration-dependent manner. The induction of apoptosis was determined by morphological changes, cleavage of poly(ADP-ribose) polymerase, alteration of Bax/Bcl-2 expression ratio and caspase activities. Flow cytometric analysis revealed that HS-1793 induced G2/M arrest in the cell cycle progression in both types of ...
Resveratrol (RVT) is a polyphenolic compound found mainly in the grape and attributed with various pharmacological properties, among them their antioxidant activity. In the present study, we assess the antioxidant activity of resveratrol on oxidative damage induced by ferrous iron/ascorbate (100 µM/150 µM) in sperm of CD1+ mice. We evaluated several parameters in spermatozoa treated with or without resveratrol: (i) sperm quality analysis; (ii) mitochondrial transmembrane potential (Δѱm); (iii) ROS generation; (iv) superoxide dismutase (SOD) activity; (v) glutathione peroxidase (GPX) activity; (vi) lipid peroxidation; (vii) and in vitro fertilization (IVF) capability. Spermatozoa treated with RVT (15 µg/mL) before ferrous iron/ascorbate treatment exhibited: a significant increase in motility (8-fold), a significant increase in viability (2-fold), a significant increase in Δѱm (1.15-fold), accompanied with a significant decrease in the generation of ROS (4.96-fold), a significant decrease in GPX
This Optimized Resveratrol and Super Bio-Curcumin exhibit synergistic benefits, while Optimized Resveratrols co-factors function as potentiating secondary antioxidants. ,Fisetin, found in strawberries, has the power to switch on cell signaling molecules that support youthful gene expression, DNA protection, and healthy cellular function. Fisetin also supports aging neurons in the presence of oxidative stress. And, most importantly, it works in synergy with resveratrol. Researchers have uncovered compelling evidence of fisetins ability to stabilize resveratrol by shielding it from metabolic breakdown, thus extending its beneficial effects. Pterostilbene, a stilbene compound from the same family as resveratrol, has been shown to work synergistically with resveratrol, to unlock ones longevity genes thus conferring even greater anti-aging benefits, including the prevention of age related hair loss. In laboratory tests, pterostilbene has shown promise for supporting cardiovascular health, glucose ...
Obesity, diabetes, hypertension, and hyperlipidemia constitute risk factors for morbidity and premature mortality. Based on animal and in vitro studies, resveratrol reverts these risk factors via stimulation of silent mating type information regulation 2 homolog 1 (SIRT1), but data in human subjects are scarce. The objective of this study was to examine the metabolic effects of high-dose resveratrol in obese human subjects. In a randomized, placebo-controlled, double-blinded, and parallel-group design, 24 obese but otherwise healthy men were randomly assigned to 4 weeks of resveratrol or placebo treatment. Extensive metabolic examinations including assessment of glucose turnover and insulin sensitivity (hyperinsulinemic euglycemic clamp) were performed before and after the treatment. Insulin sensitivity, the primary outcome measure, deteriorated insignificantly in both groups. Endogenous glucose production and the turnover and oxidation rates of glucose remained unchanged. Resveratrol ...
RAW Resveratrol is made with a special combination of RAW Fermented Resveratrol along with organic Cabernet Sauvignon Grapes, delivering 350mg of beneficial Trans-Resveratrol. We exclusively use a raw fermented Japanese Knotweed to ensure that the active components are available to the body and, most importantly, that the product is well-tolerated in the digestive system. Why RAW Resveratrol RAW Resveratrol 60 Vegetarian Capsules by Garden of Life is a powerful, whole food resveratrol formula, combining RAW fermented resveratrol, 23 RAW fruits and vegetables, including Cabernet Sauvignon Grapes, plus live probiotics and digestive enzymes. A synergistic blend of bioactive phytonutrients with a wide array of beneficial cofactors, RAW Resveratrol helps support antioxidant activity. RAW Resveratrol is a highly potent source of polyphenols, providing 350mg of trans-Resveratrol per serving, as much trans-resveratrol as in 200 bottles of red wine. RAW Resveratrol provides the benefits of red
Ho quindi applicato le conoscenze acquisite lavorando con il Resveratrolo allo Pterostilbene, lanalogo 3,5-dimetilato del Resveratrolo. Poiché lo Pterostilbene è ancora poco caratterizzato abbiamo innanzitutto eseguito una dettagliata analisi sulla distribuzione della molecola negli organi dopo la sua somministrazione orale (capitolo 5, "Pharmacokinetics and tissue distribution of pterostilbene in the rat"). I livelli di Pterostilbene negli organi sono risultati molto elevati in paragone a quelli misurati nel sangue. Tuttavia, eccetto che nel cervello, il suo metabolita solfato è risultato la specie più abbondante nei tessuti esaminati. Abbiamo quindi testato una piccola libreria di pro-farmaci dello Pterostilbene basati sul legame carbammico N-monosostituito e amminoacidi naturali. Come ci attendavamo, la stabilità di questi derivati è compresa in un intervallo utile per luso come pro-farmaci. Lassorbimento dei derivati recanti amminoacidi apolari è fortemente incrementato (capitolo ...
Resveratrol is a naturally occurring trihydroxyl-diphenylethylene compound that has been shown experimentally to have beneficial effects in the treatment of cancer and cardiovascular disease. Resveratrol induces programmed cell death (apoptosis) in these cells and activates important signal transducing proteins including extracellular signal-regulated kinases (ERKs) 1 and 2 in cancer cells. Resveratrol also causes nuclear accumulation of the enzyme cyclooxygenase (COX)-2 and of the oncogene suppressor protein, p53. We have studied the molecular basis of the anticancer actions of resveratrol using human ovarian carcinoma (OVCAR-3) cells. Our findings include the following: (i) nuclear accumulation of COX-2 in resveratrol-treated cells is blocked by the ERK1/2 inhibitor, PD98059; (ii) an inhibitor of COX-2 activity, NS398, prevents accumulation of ERK1/2, COX-2, activated p53 and small ubiquitin-like modifier (SUMO-1) in the nucleus; (iii) apoptosis, quantitated by nucleosome enzyme-linked ...
Resveratrol is a phytoalexin - antibacterial and anti-fungal substances produced by plants as part of their defense system against pathogens. Red grape skin is a particularly rich source of resveratrol. It has been suggested that Resveratrol may play a si
Abstract:. The purpose of the present study was to assess the effect of resveratrol (RSV) treatment on the pharmacokinetics of diclofenac (DIC) in healthy human volunteers. The open-label, two period, sequential study was conducted in 12 healthy human volunteers. A single dose of RSV 500 mg was administered daily for 10 days during treatment phase. A single dose of DIC 100 mg was administered during control and after treatment phases under fasting conditions. The blood samples were collected after DIC dosing and analyzed by HPLC. Treatment with RSV significantly enhanced maximum plasma concentration (Cmax) (1.73 to 2.91 µg/mL), area under the curve (AUC) (5.05 to 9.95 µg h/mL), half life (T1/2) (1.12 to 1.76 h) and significantly decreased elimination rate constant (Kel) (0.71 to 0.41 h−1), apparent oral clearance (CL/F) (14.58 to 6.48 L/h) of DIC as compared to control. The geometric mean ratios for Cmax, AUC, T1/2, Kel and CL/F of DIC were 1.75, 2.12, 1.65, 0.61 and 0.47, respectively were ...
Background: Many animal and in vitro studies have shown that resveratrol, a naturally occurring polyphenol found in red wine, can increase cognition, reduce neural degeneration, promote clearance of amyloid-beta peptides, and alter aging mechanisms. Therefore, resveratrol may reduce the symptoms of Alzheimers disease (AD) and possibly its pathology. Objective: A pilot study to determine the effects of resveratrol on cognitive, behavioral and global functioning in patients with mild-to-moderate AD on standard therapy. Design: Randomized, double-blind, placebo-controlled clinical trial. Participants: 50 patients with mild-moderate Alzheimers disease (AD) defined as a Mini-Mental State Exam (MMSE) between 10-27 will be enrolled in the study. Patients must have an established diagnosis of AD by NINCDS diagnostic criteria, be on stable dose of cognitive enhancing medications (cholinesterase inhibitor and/or NMDA receptor antagonist) Screening/Enrollment: Institutional Review Board approval will be ...
Researchers compared the effects of an unenhanced honey bee diet to diets containing two different concentrations of resveratrol.
TY - JOUR. T1 - Resveratrol improves the mitochondrial function and fertilization outcome of bovine oocytes. AU - Takeo, Shun. AU - Sato, Daichi. AU - Kimura, Koji. AU - Monji, Yasunori. AU - Kuwayama, Takehito. AU - Kawahara-Miki, Ryoka. AU - Iwata, Hisataka. PY - 2014. Y1 - 2014. N2 - The aim of the present study was to address the effect of resveratrol-mediated upregulation of sirtuin 1 (SIRT1) during oocyte maturation on mitochondrial function, the developmental ability of oocytes and on mechanisms responsible for blockage of polyspermic fertilization. Oocytes collected from slaughterhouse-derived ovaries were cultured in TCM-199 medium supplemented with 10% FCS and 0 or 20 μM resveratrol (Res). We examined the effect of Res on SIRT1 expression in in vitro-matured oocytes (Exp 1); fertilization and developmental ability (Exp 2); mitochondrial DNA copy number (Mt number), ATP content and mitochondrial membrane potential in matured oocytes (Exp 3); and the time required for proteinase to ...
Despite the interest in stilbenoids like pterostilbene and resveratrol, their bioavailability is in doubt. The researchers believe that some of their applications may even offer topical solutions to improve the barrier defense in infections and wounds. Stilbenoids are basically compounds that are produced by plants as a means of fighting infection. This research goes on to show that combining stilbenoids with vitamin D will have a better impact than any of these compounds would offer individually.. The study analyzed 446 different compounds for their ability to boost the immune system. According to Adrian Gombart, an associate professor at the OSU College of Science, these two compounds stood out from among the hundreds that were tested. He mentions that their synergy with vitamin D in terms of increasing the expression of the CAMP gene was intriguing and significant.. Resveratrol has already been subjected to all sorts of studies to examine its possible benefits, and it seems as if the compound ...
Fingerprint Entra nei temi di ricerca di Advance on Resveratrol Application in Bone Regeneration: Progress and Perspectives for Use in Oral and Maxillofacial Surgery. Insieme formano una fingerprint unica. ...
p,Mice fed the standard diet showed the induction of serum OVA-specific IgE production following oral sensitization with OVA plus CT (,xref ref-type=fig rid=pone-0044338-g001,,bold,Figure 1B,/bold,,/xref,) as previously described ,xref ref-type=bibr rid=pone.0044338-Li1,[12],/xref,. In contrast, the mice fed a standard diet plus resveratrol showed a decrease in OVA-specific IgE production after oral sensitization (,xref ref-type=fig rid=pone-0044338-g001,,bold,Figure 1B,/bold,,/xref,). Consistent with the findings of the serum IgE levels, resveratrol-fed mice sensitized with OVA plus CT showed a smaller drop in the extent of rectal temperatures than the control mice sensitized with OVA plus CT, upon intraperitoneal OVA challenge (,xref ref-type=fig rid=pone-0044338-g001,,bold,Figure 1C,/bold,,/xref,). In addition, OVA-specific IL-13 and IFN-γ productions from splenocytes and mesenteric lymph nodes (MLN)-derived cells were decreased in resveratrol-fed mice in comparison to those ...
Page 2 of 3 - Polydatin - Better than Resveratrol? - posted in Resveratrol: There are some papers mentioned by hedgehog in this POST. Polydatin does metabolize to resveratrol in significant amounts. Right, I am not sure of the benefits of taking polydatin. Yes, it does absorb much better (and dissolves easier, of course) but as niner mentioned, its pretty quickly metabolized to resveratrol in the liver and then glucuronidated just like resveratrol.The main thing would be if the AUCs and...