EU5 Non-Vascular Stents Market Outlook to 2020 is a new market research publication announced by Reportstack. This report provides key market data on the EU5 Non-Vascular Stents market. The report provides value, in millions of US dollars, volume (in units) and average prices (in US dollars) within market segments - Biliary Stents (Plastic Biliary Stents and Metal Biliary Stents (Metal Non-Covered Biliary Stents, Metal Partially Covered Biliary Stents and Metal Fully Covered Biliary Stents)), Gastrointestinal Stents (Fully Covered, Partially Covered and Non-Covered Gastrointestinal Stents), Airway Stents (Silicone Airway Stents and Metallic Airway Stents (Fully Covered and Uncovered Metallic Airway Stents) and Urinary Tract Stents ((Ureteral Stents (Metal, Polymer and Bioabsorbable Ureteral Stents), Prostate Stents (Metal, Polymer and Bioabsorbable Prostate Stents) and Urethral Stents (Metal, Polymer and Bioabsorbable Urethral Stents ...
View details of top carotid artery stent placement hospitals in Thane. Get guidance from medical experts to select best carotid artery stent placement hospital in Thane
Objective To compare the application effect and cost in intracoronary stent implantation between domestic and imported drug eluting stent. Methods A total of 791 coronary heart disease patients undergoing intracoronary stent implantation were selected in a Grade 3 and first-class hospital in 2013,and they were divided into A group( using domestic drug eluting stent,n = 398) and B group( using imported drug eluting stent,n = 393) according to the types of stents. During the intracoronary stent implantation,patients of A group used Shanghai Minimally-invasive Firebird Ⅱ Drug-eluting Stents,while patients of B group received United States Medtronic Endenvor Drug Eluting Stents. Clinical data,operative success rate,locations of coronary artery lesions,number of implanted stents,clinical outcome,hospitalization related expenses and incidence of complications were compared between the two groups. Results Patients of the two groups completed the operation successfully,the operative success rates of the two
TY - JOUR. T1 - Frequency of Slow Coronary Flow Following Successful Stent Implantation and Effect of Nitroprusside. AU - Airoldi, Flavio. AU - Briguori, Carlo. AU - Cianflone, Domenico. AU - Cosgrave, John. AU - Stankovic, Goran. AU - Godino, Cosmo. AU - Carlino, Mauro. AU - Chieffo, Alaide. AU - Montorfano, Matteo. AU - Mussardo, Marco. AU - Michev, Iassen. AU - Colombo, Antonio. AU - Maseri, Attilio. PY - 2007/4/1. Y1 - 2007/4/1. N2 - Nitroprusside (NTP) is used for the treatment of slow coronary flow (SCF) after coronary interventions. The wide variation in dosage, route, and timing of its administration in the reported studies prevents an objective assessment of its efficacy. We report the incidence and response to a standardized NTP protocol of SCF after successful stent implantation. Selective intracoronary administration of incremental doses (initial bolus of 80 μg incremented by 40 μg) of NPT was assessed in 21 patients who developed SCF in a series of 2,212 consecutive patients who ...
Self-Expandable Stents in the Gastrointestinal Tract Health Beauty Health Care Medicine Drugs OTC Drugs Treatments Description:Self-expandable stents were initially placed for the treatment of cardiovascular diseases but now play an integral role in the relief of benign and malignant obstruction of the gastrointestinal tract and biliary system. Self-Expandable Stents in the Gastrointestinal Tract
From Cardiology Team, Department of Medicine, Pamela Youde Nethersole Eastern Hospital, Hong Kong. LAM and LI: Use of Distal Protection Device for Percutaneous Intervention in Native Coronary Arteries. Microembolization of particulate debris during percutaneous coronary intervention (PCI) will lead to various degree of microvascular obstruction, terminating in no-reflow phenomenon observed angiographically. Different methods, including angiography, non-invasive imaging, and assays of myocardial injury markers, have been used for detection of occurrence of microvascular obstruction. The prevalence of, and the adverse prognosis associated with microvascular obstruction have led to the concept and application of distal protection for coronary interventions. While its value has been confirmed in saphenous vein grafts intervention, data is now growing to support use of distal protection devices in native coronaries. Findings from a local registry that reveals the initial experience on use of ...
The Coronary Stents Market market report provides an overview of Coronary Stents Market, as well as its PEST Analysis. Additionally, the report provides insight on the Coronary Stents Market market share of the individual Coronary Stents Market devices, current and forecasted Coronary Stents Market market size from 2018 to 2026 segmented by seven major markets. The report also covers the market drivers, market barriers and unmet medical needs to curate best of the opportunities and assesses underlying potential of the market.. Coronary Stents Overview. Coronary stents are strechable devices that are used to expand the arteries in patients that can further stop the blockage caused in the arteries. Some patients suffer from coronary diseases due to the build-up of plaque in arteries. Therefore, coronary stents can be used in expanding the narrowed arteries, exempting any chance of heart attack or other coronary disorders within patients.. Request free sample copy- ...
Airway self-expandable metallic stents (SEMS) were initially studied in malignant airway obstruction; however, their use in benign airway diseases has become progressively more frequent. This may be explained by their ease of insertion compared with silicone stents, which require rigid bronchoscopy for insertion. While initial experience with SEMS in benign disease suggested efficacy and promising short-term safety profile, long-term follow-up revealed significant complication rates. In addition to a high complication rate, the management of these complications is made more difficult by the semipermanent nature of these devices. Reported complications include infection, granulation tissue formation, stent migration, stent fracture, airway perforation and fistula formation, as well as extension of the initial injury, potentially eliminating other therapeutic options such as surgical resection. Therefore, SEMS should only be used in nonmalignant large airway disease as a last resort for patients in whom
1 Table of Contents. 1 Table of Contents 2. 1.1 List of Tables 4. 1.2 List of Figures 4. 2 Introduction 5. 2.1 What Is This Report About? 5. 2.2 Non-Vascular Stents Market Segmentation 5. 2.3 Definitions of Markets Covered in the Report 6. 3 Non-Vascular Stents Market, India 8. 3.1 Non-Vascular Stents Market, India, Revenue ($m), 2009-2016 8. 3.2 Non-Vascular Stents Market, India, Revenue ($m), 2016-2023 10. 3.2.1 Airway Stents Market, India, Revenue ($m), by Segment, 2009-2016 12. 3.2.2 Enteral Stents Market, India, Revenue ($m), by Segment, 2009-2016 14. 3.2.3 Pancreatic and Biliary Stents Market, India, Revenue ($m), by Segment, 2009-2016 16. 3.2.4 Urinary Tract Stents Market, India, Revenue ($m), by Segment, 2009-2016 18. 3.2.5 Airway Stents Market, India, Revenue ($m), by Segment, 2016-2023 20. 3.2.6 Enteral Stents Market, India, Revenue ($m), by Segment, 2016-2023 22. 3.2.7 Pancreatic and Biliary Stents Market, India, Revenue ($m), by Segment, 2016-2023 24. 3.2.8 Urinary Tract Stents ...
The FAIR trials objective was to assess safety and efficacy of angioplasty with drug-eluting balloon vs. standard angioplasty for the treatment of symptomatic superficial femoral artery in-stent restenosis. The primary endpoint was binary (≥50%) restenosis rate at six months as assessed by duplex ultrasound corelab adjudication (PSVR≥2.4). The secondary endpoints were primary angiographic success (,50% residual stenosis), six-month recurrent in-stent restenosis (≥70%) and 12-month recurrent in-stent restenosis (≥50%), six- and 12-month clinically-driven target lesion revascularisation, and clinical/haemodynamic assessment (walking distance, ankle brachial index, Rutherford category) at one, six and 12 months. The investigators also assessed the major adverse vascular events (MAVE) at 12 months.. Patients who had Rutherford class 2-4 lesions and superficial femoral artery in-stent restenosis between 70-100% as assessed by duplex ultrasound were included. Further, to be included, patients ...
Stents are used in the treatment of numerous biliary tract diseases, ranging from benign biliary diseases to malignant strictures. Two types of biliary stents find extensive use: plastic Amsterdam-type stents and self-expanding metallic stents. The more commonly used Amsterdam-type plastic stents are tubular structures with diameters ranging from 7 to 12 Fr. Further increase in the diameter of plastic stents is precluded by the working channel diameter of side-viewing endoscopes. The major limitation of these plastic stents is their limited patency (with an average time of failure of 82.7±5 days). The primary reason for failure is complete obstruction of bile flow due to occlusion by biofilm and biliary sludge.1 The obstruction rate was found to be 27% in the first 30 days of plastic stent deployment.2 The risk of occlusion increases progressively after 3 months with a median patency of 4-5 months.3 Nevertheless, plastic stents are widely used because of their low cost and their ease of removal ...
A coronary stent is a tubular structured device made of a thin mesh of wire, which may also be coated with a polymer containing a drug, or made of biodegradable materials. Coronary stents are utilized during percutaneous coronary interventions (PCIs) for the treatment of patients suffering from various coronary artery diseases (CADs) such as acute myocardial infarction, angina pectoris and others. At present, several researches are being conducted in the field of coronary stenting, in order to minimize side effects such as restenosis and thrombosis. Certain new and advanced coronary stents such as bio-absorbable stents have been commercialized in the global market, which demonstrate very less or no common side effects of coronary stenting.. Request a Sample Copy of the Report @ http://www.mrrse.com/sample/1170. The market for coronary stents can be broadly classified into three major segments, namely, bare metal stents (BMS), drug eluting stents (DES) and bio-absorbable stents. In 2011, the drug ...
BRIC Enteral Stent Procedures Outlook to 2025 - Enteral stenting Procedures using Fully Covered Enteral stents, Enteral stenting Procedures using Non-Covered Enteral stents and Enteral stenting Procedures using Partially Covered Enteral stents
OBJECTIVE. The purpose of this prospective study was to evaluate the efficacy of expandable metal stents for colonic decompression in patients presenting with acute malignant obstruction and to describe the associated radiographic findings. SUBJECTS AND METHODS. Using both fluoroscopic and endoscopic guidance, we placed expandable metal stents within the colons of 13 patients presenting with acute malignant obstruction. Stents were placed in four patients to permit a standard bowel cleansing before surgical resection with primary anastomosis. In the other nine patients, stents were placed for palliation of nonresectable tumors, obviating colostomy. Outcomes and complications were analyzed. The radiologic aspects of procedural planning, stent placement, assessment after placement, and detection of complications were evaluated. RESULTS. Of the four surgical candidates who were successfully resected with primary anastomosis, two received incomplete bowel cleansing because of stent migration with ...
Since the drug eluting stents have provided better results concerning restenosis and repeat revascularization comparing to bare metal stents, percutaneous coronary interventions are performing increasingly in more complex stenoses. However, drug eluting stents did not show any advantage on prevention of myocardial infarction and survival. Currently there is no any completed controlled randomized study showing the superiority or equality of drug eluting stents over coronary bypass surgery by means of efficacy and safety. While the long-term results of drug eluting stents still unclear, everyday progressively more patients with multivessel disease are undergoing percutaneous coronary intervention with drug eluting stent implantation. The aim of this review is to discuss the efficacy and safety of drug eluting stents in patients with multivessel disease.. Keywords: Coronary artery disease, stent, drug-eluting stent, multivessel disease, coronary bypass ...
TY - JOUR. T1 - Chronic Arterial Responses to Polymer-Controlled Paclitaxel-Eluting Stents. T2 - Comparison with Bare Metal Stents by Serial Intravascular Ultrasound Analyses: Data from the Randomized TAXUS-II Trial. AU - Tanabe, Kengo. AU - Serruys, Patrick W.. AU - Degertekin, Muzaffer. AU - Guagliumi, Giulio. AU - Grube, Eberhard. AU - Chan, Charles. AU - Munzel, Thomas. AU - Belardi, Jorge. AU - Ruzyllo, Witold. AU - Bilodeau, Luc. AU - Kelbaek, Henning. AU - Ormiston, John. AU - Dawkins, Keith. AU - Roy, Louis. AU - Strauss, Bradley H.. AU - Disco, Clemens. AU - Koglin, Jörg. AU - Russell, Mary E.. AU - Colombo, Antonio. PY - 2004/1/20. Y1 - 2004/1/20. N2 - Background-Polymer-controlled paclitaxel-eluting stents have shown a pronounced reduction in neointimal hyperplasia compared with bare metal stents (BMS). The aim of this substudy was to evaluate local arterial responses through the use of serial quantitative intravascular ultrasound (IVUS) analyses in the TAXUS II trial. Methods and ...
At present, the product information of intracoronary stents provided by the industry contains only limited technical data restricting judgments on the in vivo performance of individual products. Available experimental and clinical evidence suggests that interventional target sites display highly heterogeneous biomechanical behavior needed to be matched by specific stent and stent delivery system characteristics. To allow individualized stent-lesion matching, both, understanding of biomechanical properties of the atherosclerotic coronary artery lesions and expert knowledge of the intracoronary stent systems, are required. Here, the authors review some of the initial data on mechanical properties of coronary artery lesions potentially relevant to stenting and suggest standards for technical documentation of intracoronary stents.. ...
Japan Urinary Tract Stent Procedures Outlook to 2025 - Prostate Stenting Procedures, Ureteral Stenting Procedures and Urethral Stenting Procedures
A trend which will definitely change the market is the emergence of bio-absorbable stents. Since 1995, the introduction of new products such as bio-absorbable scaffolds, biodegradable polymers, and bifurcation stents is likely to increase the use of vascular stents in interventional cardiology. These stents have the potential to eliminate the complications of durable polymer stents. This will induce a significant positive shift in the treatment of artery stenosis and encourage affected individuals to undergo vascular stenting. Bio-absorbable stents restore blood flow by opening the clogged blood vessel and provide support until the damaged blood vessel heals. Unlike metallic stents, the body gradually metabolizes the bio-absorbable stent and entirely absorbs them over time.. Ask Sample PDF of Vascular Stents Market Report @ http://www.marketreportsworld.com/enquiry/request-sample/10279222 According to the Vascular Stents Market report, a key growth driver is the demand for minimally invasive ...
Cerebral embolization during carotid artery stenting (CAS) can often precipitate severe adverse neurological effects. Most major clinical studies of CAS have used distal filters for cerebral protection and have compared the neurologic complication rates with those of carotid endarterectomy (CEA). Many currently available embolic protection devices, however, have limited efficacy in capturing microembolic debris that is liberated during stenting, pre-dilatation and post-dilatation. Distal protection systems are furthermore limited by the need to cross the lesion prior to deployment. Some studies have shown a relatively high incidence of cerebral infarction even when distal protection devices are employed.. Cerebral protection with carotid flow reversal is a method that was developed as an alternative to the use of distal protection devices. While novel in its approach, this method too has its limitations. Another technique developed employs carotid flow reversal prior to traversing the stenosis ...
Cerebral embolization during carotid artery stenting (CAS) can often precipitate severe adverse neurological effects. Most major clinical studies of CAS have used distal filters for cerebral protection and have compared the neurologic complication rates with those of carotid endarterectomy (CEA). Many currently available embolic protection devices, however, have limited efficacy in capturing microembolic debris that is liberated during stenting, pre-dilatation and post-dilatation. Distal protection systems are furthermore limited by the need to cross the lesion prior to deployment. Some studies have shown a relatively high incidence of cerebral infarction even when distal protection devices are employed.. Cerebral protection with carotid flow reversal is a method that was developed as an alternative to the use of distal protection devices. While novel in its approach, this method too has its limitations. Another technique developed employs carotid flow reversal prior to traversing the stenosis ...
Global Drug-Eluting Stents Market 2025 Report Provides Porters Five Forces Analysis Illustrates the Potency of Buyers & Suppliers Operating in the Industry & the Quantitative Analysis of The Global Market from 2019 to 2025 is Provided to Determine the Market Potential.. Drug eluting stents are tubular mesh-like structures of thin wires that are placed inside coronary arteries during percutaneous coronary interventions (PCIs) to help treat acute myocardial infarction, atherosclerosis, angina pectoris, and other coronary disorders. Presently, a wide range of stents are available in the global drug eluting stents market due to technological advancements leading to their incorporation into stenting technologies. Drug eluting stents are made of metal coated with a pharmacologic agent, which is known to suppress restenosis. These stents have proven to be efficient in the treatment of acute myocardial infraction, angina pectoris, multiple vessel disease, and atherosclerosis. Drug eluting stents have ...
TY - JOUR. T1 - Platelet function and total length of intracoronary stents. T2 - Is there a correlation? [2]. AU - Cummings, Charles C.. AU - McKenzie, Marcus E.. AU - Horowitz, Eric D.. AU - Oshrine, Benjamin R.. AU - Callahan, Kevin P.. AU - Gurbel, Paul A.. AU - Serebruany, Victor L.. PY - 2001/1/15. Y1 - 2001/1/15. KW - Aggregometry. KW - Coronary artery disease. KW - Glycoprotein IIb/IIIa. KW - Intracoronary stents. KW - Platelets. UR - http://www.scopus.com/inward/record.url?scp=0035862597&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0035862597&partnerID=8YFLogxK. U2 - 10.1016/S0049-3848(00)00372-8. DO - 10.1016/S0049-3848(00)00372-8. M3 - Letter. C2 - 11392314. AN - SCOPUS:0035862597. VL - 101. SP - 105. EP - 107. JO - Thrombosis Research. JF - Thrombosis Research. SN - 0049-3848. IS - 2. ER - ...
Hello and welcome to the December issue of Vascular Disease Management. I have chosen to comment on Deepika Kalisetta and colleagues case report on Balloon Assisted Dislodgement of a Trapped Directional Atherectomy Catheter (the Ocelot device) During Treatment of In-Stent Restenosis (ISR).. Stenting of femoropopliteal arterial obstructive lesions has been demonstrated to result in higher primary patency than standard balloon angioplasty. Stenting is also routinely utilized to treat flow-limiting dissections following PTA and atherectomy. Therefore, stenting is commonly utilized in treating symptomatic femoral and popliteal arterial obstructions. Unfortunately, restenosis and reocclusion are common following stenting. Whereas stent grafts tend to develop recurrent stenosis only at the edge of the stents, standard nitinol self-expanding stents often develop diffuse in-stent restenosis secondary to neointimal hyperplasia and reocclusion when there is superimposed thrombus. Stent restenosis can ...
Unlike the BENESTENT I and STRESS trials, which showed a 30% reduction in late restenosis with the use of stents, angiographic restenosis in OCBAS was similar between PTCA and stented patients, as was length of hospital stay, TVR and freedom from major cardiac events. Despite the lack of benefit observed, overall costs were significantly higher in the stent than in the optimal PTCA with provisional stenting group. Despite a small sample size, the OCBAS trial suggests immediate use of coronary stents following optimal PTCA may not be warranted, but rather a delayed, conservative approach may result in similar outcomes. Given the conflicting results with trials such as DEBATE II, which showed higher costs with provisional stenting, further trials are needed before a definitive conclusion can be drawn. Finally, waiting 30 minutes to examine the early loss may not be feasible in clinical practice, and the trial was initiated before the availability of later generations of stents and does not include ...
Press Release issued Oct 5, 2017: Non-vascular stents are specialized medical devices used for relieving the strictures in gastrointestinal tract, ureteral tract and airway tracts. These are also used for holding open the narrowed lumens during complex surgical procedure to allow free flow of body fluids. On the basis of its applications there are three different types of non-vascular stents are available: pulmonology stents, urology stents, and gastroenterology stents. These stents are made using different material compositions such as metallic stents are made of stainless steel, nitinol alloys, and elgiloy. Whereas non-metallic stents are made up of synthetic polymers like resins, polyurethane, silicone.
With Habib Samady, MD, and John Wang, MD, MSc. In this edition of our Conversations with Experts series, Habib Samady, MD, director of interventional cardiology and the cardiac catheterization laboratory at Emory University Hospital in Atlanta, speaks with John Wang, MD, MSc, chief of the cardiac catheterization laboratory at MedStar Union Memorial Hospital in Baltimore, about the current and future role of bare-metal stents in the interventional cardiology landscape. Dr. Wang was the national principal investigator of the OMEGA trial, the results from which led to the FDA approval of the REBEL™ Platinum Chromium Coronary Stent System (Boston Scientific Corporation; Natick, Massachusetts).. John Wang, MD, MSc: Dr. Samady, let me first ask you: what percentage of the time do you use drug-eluting stents versus bare-metal stents in your practice? Habib Samady, MD: At Emory University Hospital, we probably use drug-eluting stents 85% of the time and bare-metal stents 15% of the time. Dr. Wang: ...
Fingerprint Dive into the research topics of Are distal protection devices protective during carotid angioplasty and stenting?. Together they form a unique fingerprint. ...
Approximately 70 percent of angioplasty procedures also involve stenting, which is the insertion of a small metal cylinder called a stent into a blood vessel. In this procedure, a collapsed stent is placed over the balloon at the tip of the catheter. When the balloon inflates, the stent pops open and reinforces the artery walls. The balloon and catheter are then withdrawn and the stent remains permanently. In a few weeks, tissue from the artery lining grows over the stent.. There are two types of stents. Bare-metal stents are plain, untreated metal cylinders. Drug-eluting stents (also called drug-coated stents) are coated with medication before they are placed in the artery. This medication helps prevent scarring and lowers the risk for restenosis (re-narrowing of the artery). Drug-eluting stents may present a higher risk for blood clot formation than bare-metal stents. ...
METHODS AND RESULTS Forty-five stents were placed in 30 patients, who were 0.2-30.2 years old (weight, 3.5-76 kg). Patients with areas of stenosis that were difficult to approach surgically were chosen. Stents were mounted over balloons and placed by standard catheterization techniques. Twenty-three patients had branch pulmonary artery stenosis. Thirty-six stents were placed successfully and had reduced pressure gradients from 50.6 +/- 24 to 15.9 +/- 13.4 mm Hg. Five patients had stents placed after atrial surgery: three in obstructed Fontan repairs, one at the superior vena cava-right atrial junction after sinus venous defect repair, and one at the site of a Glenn shunt. Atrial stents reduced pressure gradients from 9.8 +/- 8.2 to 2.0 +/- 2.6 mm Hg. One patient had a stent placed in the descending aorta after coarctation dilation, and the pressure gradient was reduced from 50 to 25 mm Hg. One patient had pulmonary vein dilation with stent placement. Two stents migrated at the time of placement; ...
Our results demonstrate the possibility of therapeutic local gene transfer using a stent platform technology and that VEGF-2 gene-eluting stents may be effective in the prevention of restenosis. The data show that VEGF-2 plasmid was effectively delivered to the vessel wall, where transcript and protein were detected for up to 10 days after stent implantation. Local VEGF-2 gene, delivered by PC-coated stents, not only improved early reendothelialization at the stented site but also reduced neointimal proliferation as assessed by IVUS at 3 months of follow-up. IVUS and histomorphometric assessment revealed significant differences in neointimal formation in hypercholesterolemic animals after implantation of VEGF stents compared with PC control stents. Moreover, and in contrast to all other currently marketed drug-eluting stents, VEGF-2-eluting stents result in acceleration of anatomic and functional endothelial recovery. These data, therefore, represent the first demonstration of an antirestenosis ...
Headline: Bitcoin & Blockchain Searches Exceed Trump! Blockchain Stocks Are Next!. World Stents Market by Product (coronary, peripheral, and stent-related implants), by Material (Metallic, Polymeric, Natural) - Global Opportunity Analysis and Industry Forecast, 2014-2022. View full report at World Stents Market by Product (coronary, peripheral, and stent-related implants), by Material (Metallic, Polymeric, Natural) - Global Opportunity Analysis and Industry Forecast, 2014-2022. Summary:. A stent is a metallic or a polymer tube implanted into the lumen of any blood vessel or a duct in order to keep the passage open. A variety of stents for different clinical conditions are available in the market. A stent implant is most commonly used for the treatment of cardiac abnormalities such as blocked blood vessels. In addition, stents are implanted in the esophagus to allow the passage of food and beverages in patients suffering from esophageal cancer. They are also inserted in the ureter to prevent ...
Vascular Stents Market: By Material (Metal Stents, Standard Polymeric Stents, and Biodegradable Polymeric Stents) & By Region (Europe, North America, Asia-Pacific, RoW)-Forecast (2016-2022) Vascular Stents - Market research report and industry analysis - 10582518
Press Release issued Apr 23, 2015: Cardiovascular devices industry is growing at a significant rate globally, due to increasing number of heart diseases and other cardiovascular problems cases. In addition, technological advancement in this field and growing awareness has increased the growth of cardiovascular devices market. Coronary stents refer to the medical devices that are tubular in nature and fixed in coronary artery to keep artery open, for proper supply of blood. Continuous increase in the cases of cardiovascular problems has led a significant growth in Coronary Stents Market. Out of global market for coronary stents, North American coronary stents market has the largest share. This is due to increased prevalence of coronary heart diseases and technological advancement in the region. In addition, government initiatives and better reimbursement scenario has led to increase in North American coronary stents market.
Coronary artery stenosis is commonly treated by stent placement via percutaneous intervention, at times requiring multiple stents that may overlap. Stent overlap is associated with increased risk of adverse clinical outcome. While changes in local blood flow are suspected to play a role therein, hemodynamics in arteries with overlapping stents remain poorly understood. In this study we analyzed six cases of partially overlapping stents, placed ex vivo in porcine left coronary arteries and compared them to five cases with two non-overlapping stents. The stented vessel geometries were obtained by micro-computed tomography of corrosion casts. Flow and shear stress distribution were calculated using computational fluid dynamics. We observed a significant increase in the relative area exposed to low wall shear stress ( ...
Perioperative Management of Patients with Coronary Stents Perioperative Management of Patients with Coronary Stents 1. Determine the type (BMS, DES) and location in the coronary circulation of stents placed in the 2. When possible, obtain catheterization/stent procedure report to identify any high risk factors for a. Low EF b. Prior coronary brachytherapy c. Long Stents d. Proximal vessel involvement (i.e. L main) e. Multiple Lesions f. g. Ostial/bifurcation lesions h. Small vessels i. 3. Consult with a patients cardiologist and, when high risk, with the interventional cardiologist. When no cardiologist is on record, consult: a. Hillcrest Cardiology Consult b. Thornton Cardiology On-call 4. Perform the surgery in a center with 24-h interventional cardiology coverage so that stent thrombosis, if occurs, could be treated by PCI. 5. Inform patients of risk of perioperative stent thrombosis on preoperative visit ...
Global Market Watch:. BRICSS Coronary Stents market value is expected to reach US$1 billion by 2016, primarily supported by the product types - Drug Eluting Stents, Bare Metal Stents, Absorbable Stents and …etc. China accounts for nearly 28% of the market share and India claims more than 23%. In terms of CAGR, India is the fastest growing region while China and South Korea are just behind. Among the product types, Drug Eluting Stents account more nearly half of the market value while Absorbable Stents segments indicate a close 14%. In case of Stent Coating, Polymer depicts the largest CAGR while Non-Polymer and Inorganic in second and third place respectively.. Browse Full Research Report With TOC on http://www.radiantinsights.com/research/coronary-stents-emerging-markets. Healthcare Industry division has been witnessing a drastic change regarding the new innovation and technology which in terms are applied in improving from sector to sector since the past 3-5 years. Cardiovascular industry ...
Fingerprint Dive into the research topics of Delayed deformation of self-expanding stents after carotid artery stenting for postendarterectomy restenoses. Together they form a unique fingerprint. ...
Cardiovascular disease is the dominant cause of mortality in developed countries, with coronary artery disease (CAD) a predominant contributor. The development of stents to treat CAD was a significant innovation, facilitating effective percutaneous coronary revascularization. Coronary stents have evolved from bare metal compositions, to incorporate advances in pharmacological therapy in what are now known as drug eluting stents (DES). Deployment of a stent overcomes some limitations of balloon angioplasty alone, but provides an acute stimulus for thrombus formation and promotes neointimal hyperplasia. First generation DES effectively reduced in-stent restenosis, but profoundly delay healing and are susceptible to late stent thrombosis, leading to significant clinical complications in the long term. This review characterizes the development of coronary stents, detailing the incremental improvements, which aim to attenuate the major clinical complications of thrombosis and restenosis. Despite these
Drug eluting stents (DES) have decreased substantially the neointimal formation after percutaneous coronary intervention (PCI). However, DES are not free from neointimal hyperplasia (NIH) and stent thrombosis, which are related to the delayed arterial healing following DES implantation. The recently introduced optical coherence tomography (OCT) enables a detailed investigation of vessel healing. The presence of peri-strut low intensity (PLI) has been described as a potential marker of abnormal neointimal healing (1,2). We investigated the late healing characteristics of stents implanted over 3 years, specifically the potential impact of PLI on NIH and restenosis.. OCT imaging (M2, Lightlab Imaging, Westford, Massachusetts) was performed in 99 patients who were treated with bare-metal stents (BMS), sirolimus-eluting stents (SES) (Cypher, Cordis, Bridgewater, New Jersey), or paclitaxel-eluting stents (PES) (Taxus, Boston Scientific, Natick, Massachusetts) from September 2007 to August 2009. The ...
Coronary stents are tubular type scaffolds that are deployed, using an inflatable balloon on a catheter, most commonly to recover the lumen size of narrowed (diseased) arterial segments. Their presence, however, can lead to adverse biological responses - in-stent restenosis, formation of neointima within 12 months of the implant, and thrombosis, formation of a blood clot inside the artery. Currently, an ideal stent - that recovers arterial shape with no adverse response - does not exist, even though, as a multi-billion dollar industry, stent design has witnessed a fairly rapid evolution from bare metal stents of increasing complexity, through shape memory alloy stents, polymer coated, drug eluting stents to biodegradable stents made from polymers or corrodible metals. The adverse responses are likely to be multi-factorial but their causes are not completely understood. However, there are studies implying a correlation between the stent design, which is a common differentiating factor between ...
Fully covered esophageal self-expandable metallic stents (SEMS) often are used for palliation of malignant dysphagia. However, experience and data on these
There are two types of urethral stents temporary and permanent. Most are made up of stainless steel or Nitinol. Absorbable stents made up of Vicryl are also available. Indication : recurrent short bulbar stricture. Patient unfit for surgery or refuse a surgery.. Contra indication: penile urethral stents are painful during erection. Stents inserted into the membranous urethra after core through urethrotomy for pelvic fracture urethral distraction defects also get blocked due to over growth of fibrosis.. The success rate of urethral stents inserted in the bulbar urethra is quoted in region of 80% a stent may migrate distally forming a stricture at the proximal end exposed part of the urethral stent not covered by urothelium may be encrusted with stones. Overgrowth of excessive epithelization may block the lumen and may need repeated resection. In those patients where the stent has to be removed endoscopic removal of the stent may be possible with some single wire stents but mesh stents need open ...
THESIS 8924 The use of stenting in peripheral arteries has been limited by rates of in-stent restenosis and stent fracture considerably higher than seen in coronary arteries. Traditional balloon expandable stainless steel stents were found to be incompatible in femoral and popliteal arteries. The change to more flexible nitinol stents saw an improvement in restenosis rates, but outcomes were still poor compared with coronary stents. The advent of drug eluting stents, which decreased restenosis rates in coronary arteries, has yet to result in significant improvement in peripheral arteries. Artery movement, caused by joint flexion, has long been thought of as a major contributory factor of the high restenosis rates seen in peripheral arteries. However, this hypothesis has not been adequately assessed, and there are other factors which could contribute to the poor performance of peripheral stents. The material properties and geometries of the coronary and peripheral arteries are different, and the ...
[124 Pages Report] Check for Discount on Global Cerebral Balloon Angioplasty & Stenting Systems Market Report 2020 by Key Players, Types, Applications, Countries, Market Size, Forecast to 2026 (Based on 2020 COVID-19 Worldwide Spread) report by Maia Research. The Cerebral Balloon Angioplasty & Stenting Systems market is expected to...
OBJECTIVE: To investigate the use of a cutting balloon to overcome aorto-ostial lesions before stent implantation and thereby reduce the restenosis rate. DESIGN: Observational follow up study. SETTING: Tertiary referral centre. PATIENTS: Eight patients (two female, six male) aged 58.2 (SD 10.1) years with Canadian Cardiovascular Society (CCS) grade II-IV angina were recruited. They each had a single target lesion (three in native coronaries, five in vein grafts). INTERVENTION AND RESULTS: After high pressure angioplasty (18 (3.8) bar), there was only a small reduction in the luminal stenosis, from 82 (9)% to 68 (10)%, as assessed by on line quantitative coronary angiography. However, using the cutting balloon there was a marked reduction in the luminal stenosis to 44 (15)%, facilitating stent insertion. Subsequent high pressure dilatation resulted in a final stenosis of 10 (7)%. At 6 (2) months follow up the marked symptomatic improvement, to CCS angina grade 0-II, was maintained and there were ...
Market Research Trade Published new report Global Aortic Stents Grafts 2019 2019: Global Industry Analysis, Size, Share, Growth, Trends, and Forecasts is committed fulfilling the requirements of the clients by giving them thorough insights into the market.. The Global Aortic Stents Grafts 2019 2019 report is expansive research reliant on Global Aortic Stents Grafts 2019, which inspects the raised structure of the present Global Aortic Stents Grafts 2019 2019 all around the globe. Arranged by the adequate methodical framework, for instance, SWOT examination, the Global Aortic Stents Grafts 2019 report exhibits a total evaluation of the significant players of the Global Aortic Stents Grafts 2019. The estimates for CAGR (Compound Annual Growth Rate) is calculated by the Global Aortic Stents Grafts 2019 report in terms of extent for the specific time length. This will similarly help the customer with comprehension and settle on a correct choice depends on a normal chart.. Request Free Sample Report ...
Drug-eluting stents work as well as bare-metal stents at keeping blocked arteries open, according to a meta-analysis in the April 23 Archives of Internal Medicine. Additionally, drug-eluting stents dont increase the risk of death, and theyre more likely to prevent narrowing of the arteries than bare-metal stents. Researchers analyzed records from 11 clinical trials involving a total of 6,551 patients; approximately two-thirds had been fitted with drug-eluting stents and one-third with bare-metal stents. About a year after the stents were placed, there were no significant differences between groups in the risks of death, stent thrombosis, or heart attack recurrence. However, patients with drug-eluting stents required revascularization nearly half as often as those with bare-metal stents. The results, write the authors, provide strong evidence of the beneficial effects of drug-eluting stents compared with bare-metal stents. ...
TY - JOUR. T1 - Comparative Outcomes of Carotid Artery Stent Placement and Carotid Endarterectomy in Patients with Chronic Kidney Disease and End-Stage Renal Disease. AU - Adil, Malik M.. AU - Saeed, Fahad. AU - Chaudhary, Saqib A.. AU - Malik, Ahmed. AU - Qureshi, Adnan I.. PY - 2016/7/1. Y1 - 2016/7/1. N2 - Background Patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD) have a high prevalence of carotid artery stenosis but are excluded from clinical trials. We sought to determine the clinical characteristics and outcomes related to carotid endarterectomy (CEA) and carotid artery stenting (CAS) in ESRD and CKD patients. Methods We determined the frequency of CAS and CEA performed in patients with ESRD and CKD and associated in-hospital outcomes using data from the nationwide inpatient sample data files from 2005 to 2011. All the in-hospital outcomes were analyzed after adjusting for potential confounders using multivariate analysis. Results Of the 43,875 CKD patients ...
TY - JOUR. T1 - Coronary Stenting with a Novel Stainless Steel Balloon-Expandable Stent. T2 - Determinants of Neointimal Formation and Changes in Arterial Geometry after Placement in an Atherosclerotic Model. AU - Carter, Andrew J.. AU - Laird, John R.. AU - Kufs, William M.. AU - Bailey, Lynn. AU - Hoopes, Timothy G.. AU - Reeves, Tim. AU - Farb, Andrew. AU - Virmani, Renu. PY - 1996/4. Y1 - 1996/4. N2 - Objectives. This study evaluated the delivery characteristics and vascular response to placement of a novel balloon-expandable stent in swine with experimentally induced atherosclerosis. Background. The Multi-Link stent is a balloon-expandable stainless steel stent with an interconnected ring structure designed to provide a high degree of compressive resistance while preserving longitudinal flexibility. The placement characteristics and vascular response to this stent in atherosclerotic coronary arteries have not been characterized. Methods. We tested the delivery characteristics and vascular ...
Results-Of 1 083 688 patients who underwent carotid endarterectomy or carotid artery stent placement, 11 341 (1%) patients developed NSTEMI during hospitalization. After adjusting for constitutional variables and risk factors, NSTEMI was associated with higher rates of in-hospital mortality (odds ratio, 8.6; 95% confidence interval, 7.0-10.7; P≤0.0001) and composite end point of stroke, cardiac events, and death (odds ratio, 14.6; 95% confidence interval, 13.0-16.5; P≤0.0001).. ...
Evidence-based recommendations on carotid artery stent placement for symptomatic extracranial carotid stenosis (narrowed carotid arteries in the neck)
Purpose: Comparison of the biocompatibility of self-expanding polyethylene terephthalate (PET) stents with self-expanding metallic stents (Wallstents). Methods: Diameter- and length-matched PET stents and Wallstents were symmetrically implanted in the paired iliac arteries of 13 crossbred domestic swine. Stent deployment was studied angiographically and with intravascular ultrasound immediately after stent implantation. The angiographic stented lumen diameter was measured using quantitative vessel analysis before, immediately after stenting, and at 6-week follow-up. Cross-section histopathology and area morphometry were performed. Results: Immediately poststenting, intravascular ultrasound revealed proximal dislocation of 5 of the 13 PET stents, whereas all metal stents were firmly embedded at the implantation site. At 6-week follow-up, three of the remaining PET stents were totally or subtotally occluded by organized thrombus, whereas all metal stents were patent. Compared with immediately ...
But OCT allows viewing the interior surfaces of the artery and stent in an awake patient. The imaging is done in the cath lab, over the same type of wire as balloons, stents, IVUS, etc. devices are delivered.. The assessment of strut coverage in stents was the goal of the ODESSA Trial (Optical coherence tomography for DES SAfety). Presented last Tuesday by Dr. Giulio Guagliumi of Ospedali Riuniti di Bergamo, Italy, the goal of this trial was to determine whether OCT could accurately measure strut coverage and stent malapposition in long lesions (greater than 20mm) that required overlapping stents. Overlapping stents are associated with an increased incidence of uncovered struts. Although the number of patients (77) and stents (189) was small, the actual number of struts analyzed was 53,047. The stents were further divided in to four groups: sirolimus-eluting (SES) or CYPHER stents, paclitaxel-eluting (PES) or TAXUS stents, zotarolimus-eluting (ZES) or ENDEAVOR stents, and bare-metal stents ...
TY - JOUR. T1 - Efficacy of the Za Self-Expandable Metal Stent for Palliation of Malignant Biliary Obstruction. AU - Varadarajulu, Shyam. AU - Tutuian, Radu. AU - Gostout, Christopher. AU - Kozarek, Richard. AU - Wilcox, C. Mel. AU - Cotton, Peter B.. PY - 2004/1. Y1 - 2004/1. N2 - Background: The efficacy and safety of the uncoated self-expandable Za metal stent for palliation of malignant distal biliary obstruction was prospectively analyzed. Methods: Twenty-one patients with unresectable malignant tumors involving mid to distal common bile duct who presented with obstructive jaundice underwent endoscopic implantation of an uncoated self-expandable metal stent. Technical success with stent placement, adverse events, patient survival, duration of stent patency, and device performance were analyzed. Results: Endoscopic biliary stenting was successful in all patients. No adverse events were encountered. The mean follow-up period of the 21 patients was 128 days (range, 3-263): 14 died of ...
A 67-year-old man with critical limb ischemia due to left common iliac artery (CIA) occlusion underwent endovascular treatment and stent deployment (Express LD, 8.0 × 37 mm and 8.0 × 17 mm, Boston Scientific, Natick, Massachusetts) (Figure 1). The symptoms of ischemia resolved after stent implantation; however, the patient felt pain while at rest in the left leg 3 years later. Angiography indicated a totally occluded left CIA at the stent site. Computed tomography angiography (CTA) revealed that the stent in the left CIA was compressed by a spinal spur (Figure 2). We speculate that the following occurred. The spinal spur gradually compressed the balloon-expandable stent as the patient performed normal daily activities; eventually, it caused the stent to fracture, causing CIA reocclusion. We performed bypass surgery between the femoral arteries to obtain sufficient blood flow to the left leg, and the patients pain was relieved. Stent implantation for stenosis of the iliac arteries is an ...
TY - JOUR. T1 - Self-Expandable Metal Stents in Esophageal Cancer in a High HIV Prevalence Area. T2 - A Survival Analysis and Evaluation of Prediction Scores. AU - Loots, Emil. AU - Anderson, Frank. AU - Clarke, Damian L. AU - Mulder, Chris J J. AU - Madiba, Thandinkosi E. PY - 2016/12. Y1 - 2016/12. N2 - INTRODUCTION: Esophageal cancer (EC) and human immunodeficiency virus (HIV) are common in parts of South Africa. Squamous cell carcinoma of the esophagus in KwaZulu-Natal, South Africa presents generally in advanced stages and is mostly palliated by the deployment of self-expandable metal stent (SEMS). This study analyses these relationships between coexistent HIV infection, SEMS deployment, and survival scores.METHODOLOGY: Information on patients managed with SEMS between October 2013 and December 2014 was retrieved from a prospective database of EC and followed up until April 2015. Data collected included demographics, HIV status, clinical presentation, prognostic indicators, management, and ...
TY - JOUR. T1 - Paclitaxel-eluting stents show superiority to balloon angioplasty and bare metal stents in femoropopliteal disease. T2 - Twelve-month zilver PTX randomized study results. AU - Dake, Michael D.. AU - Ansel, Gary M.. AU - Jaff, Michael R.. AU - Ohki, Takao. AU - Saxon, Richard R.. AU - Smouse, H. Bob. AU - Zeller, Thomas. AU - Roubin, Gary S.. AU - Burket, Mark W.. AU - Khatib, Yazan. AU - Snyder, Scott A.. AU - Ragheb, Anthony O.. AU - White, J. King. AU - Machan, Lindsay S.. N1 - Copyright: Copyright 2012 Elsevier B.V., All rights reserved.. PY - 2011/10. Y1 - 2011/10. N2 - Background-Sustained benefits of drug-eluting stents in femoropopliteal arteries have not been demonstrated. This prospective, multinational, randomized study was designed to compare the 12-month safety and effectiveness of a polymer-free, paclitaxel-coated nitinol drug-eluting stent (DES) with percutaneous transluminal angioplasty (PTA) and provisional bare metal stent (BMS) placement in patients with ...
TY - JOUR. T1 - Elective stent-graft treatment of aortic dissections. AU - Lee, Kwang Hun. AU - Jong, Yun Won. AU - Do, Yun Lee. AU - Choi, Donghoon. AU - Shim, Won Heum. AU - Byung, Chul Chang. PY - 2004/12/1. Y1 - 2004/12/1. N2 - Purpose: To retrospectively review 8 years experience with stent-graft treatment of aortic dissections at a single institution. Methods: Forty-six patients (31 men; mean age 59 years, range 38-88) underwent stent-graft treatment for 9 Stanford type A and 37 type B aortic dissections (9 acute phase, 13 subacute, 24 chronic). Custom-designed self-expanding stainless steel Z stents covered with polytetrafluoroethylene were used (n=20) until low-profile modular stent-grafts became available for percutaneous delivery (n=26). Results: Endovascular stent-graft deployment was technically successful in 44 (96%) patients; the 2 failed cases owing to intraprocedural migration and graft torsion were converted to surgery. There were 5 type I endoleaks for a clinical success ...
Despite the success of coronary stent implantations in the last decade, in-stent restenosis due to neointimal hyperplasia remains a problem to overcome. Neointimal hyperplasia is a vascular response to stent injury and mainly consists of proliferation of smooth muscle cells and deposition of extracellular matrix. Recently, local drug delivery has been advocated as a potential strategy to prevent in-stent restenosis. Unprecedented results have been obtained in early clinical studies on sirolimus-eluting and paclitaxel-eluting stents. Trials using various pharmaceutical coatings on different coronary stents are ongoing. More types of drug-eluting stents are expected on the market in the near future. Meanwhile, the evaluation of drug-eluting stents is entering the second phase in which the safety and efficacy in more complex lesion subsets and different clinical presentations are being investigated. Results including cost-benefit analyses are expected to have a tremendous impact on the practice of ...
Introduction Drug-eluting stents (DES) have reduced the rates of restenosis to less than 10%; however, increased incidence of late in-stent thrombosis, is now a major clinical problem of using DES for its consequences in terms of morbidity and mortality. Interference with the process of re-endothelialization appears to play a major role in this latent complication. Thus, the search for molecular compounds capable of preventing restenosis that also can reduce the risk of late in-stent thrombosis is of utmost importance. Previously, we have shown that certain non-steroidal anti-inflammatory drugs (NSAIDs) are capable of inhibiting rat vascular smooth muscle cell proliferation, a key element in the process of restenosis post stent deployment. Here, we evaluated whether proliferation and migration of human coronary artery smooth muscle cells (HCASMCs) is reduced by the NSAID, ibuprofen, whether this correlated with changes in the phenotype of HCASMCs and the potential molecular mechanisms involved. ...
Cypher data were so unequivocal that the FDA panel reviewing the data issued a unanimous recommendation for approval in the fall of 2002. In fact, Cypher appeared to be so effective that the Centers for Medicare and Medicaid Services took the unprecedented step of approving payment prior to the official FDA approval and launch that occurred in late April 2003. Cypher had been approved in Europe in early 2002; Taxus was released there earlier this year.. Cardiologists appear to favor the eluting stents over the bare metal stents. This preference will allow the drug-eluting stents to overtake the traditional bare metal version rapidly. In fact, Wall Street analysts predict that by the end of 2003, eluting stents will have 40 percent of the market.. Although promising to reduce the restenosis rate even further, these stents, too, are not without drawbacks. Cypher has a list price of $3,195 per stent (any size or length); several times the cost of the bare metal stents, which have decreased in price ...
TY - JOUR. T1 - Sirolimus- Versus Paclitaxel-Eluting Stents for the Treatment of Coronary Bifurcations. Results From the COBIS (Coronary Bifurcation Stenting) Registry. AU - Song, Young Bin. AU - Hahn, Joo Yong. AU - Choi, Seung Hyuk. AU - Choi, Jin Ho. AU - Lee, Sang Hoon. AU - Jeong, Myung Ho. AU - Kim, Hyo Soo. AU - Seong, In Whan. AU - Yang, Ju Young. AU - Rha, Seung Woon. AU - Jang, Yangsoo. AU - Yoon, Jung Han. AU - Tahk, Seung Jea. AU - Seung, Ki Bae. AU - Park, Seung Jung. AU - Gwon, Hyeon Cheol. PY - 2010/4/20. Y1 - 2010/4/20. N2 - Objectives: We aimed to compare the long-term clinical outcomes of patients treated with sirolimus-eluting stents (SES) or paclitaxel-eluting stents (PES) for coronary bifurcation lesions. Background: There are limited data regarding comparisons of SES and PES for the treatment of bifurcation lesions. Methods: Patients who received percutaneous coronary intervention for non-left main bifurcation lesions were enrolled from 16 centers in Korea between January ...
TY - GEN. T1 - Design and optimization of functionally graded superelastic niti stents. AU - Khurana, Jivtesh B.. AU - Frecker, Mary. AU - Pauli, Eric M.. N1 - Funding Information: The authors gratefully acknowledge the support of the Pennsylvania Manufacturing Innovation Program.. PY - 2020. Y1 - 2020. N2 - Endoscopic stents are being used by surgeons in off-label uses to manage leaks and perforations in the gastrointestinal tract. Commercially available stents are primarily designed to open strictures in the esophagus through tissue compression. The stents incorporate a woven NiTi wire to produce a stiff and linear tubular shape that conforms to the esophagus. In off-label uses, where the stents are placed in non-esophageal locations the stents must bend, the stents show a high propensity to migrate from their initial location causing unwanted complications. In this paper, a new stent design incorporating functionally graded NiTi is presented and explored. First, a functionally graded NiTi ...
Be informed that , National Pharmaceuticals Pricing Authority (NPPA) vide notification bearing number SO NO 412(E) dated 13th February 2017 has fixed a ceiling price on Bare Metal Stents and Drug Eluting Coronary Stents
Data were obtained from the National Inpatient Sample (NIS) from 2002 to 2009, which includes all-payer discharge information from a national survey of nonfederal hospitals. A comprehensive synopsis on NIS data is available at http://www.hcup-us.ahrq.gov.. International Classification of Disease, 9th Revision; Clinical Modification (ICD-9-CM) codes and procedure codes 00.63 and 38.12 were used, respectively, to identify patients undergoing CAS or CEA. Patients with both procedure codes were excluded. If a patients discharge diagnosis (diagnostic fields 1-15) was either carotid artery stenosis with stroke (433.11) or, if there was carotid artery stenosis without stroke (433.10), with subsequent code for transient ischemic attack (435), patients were classified as symptomatic. ICD-9-CM diagnosis code 410.71 was used to identify cases with NSTEMI. We excluded all the patients with other types of MI using ICD-9 diagnosis codes 410.0 to 410.6 and 410.8 to 410.9.. Study variables include age, sex, ...
TY - JOUR. T1 - Carotid Stenting Using Tapered and Nontapered Stents. T2 - Associated Neurological Complications and Restenosis Rates. AU - Brown, Katherine E.. AU - Usman, Asad. AU - Kibbe, Melina R.. AU - Morasch, Mark D.. AU - Matsumura, Jon S.. AU - Pearce, William H.. AU - Amaranto, Daniel J.. AU - Eskandari, Mark K.. PY - 2009/7/1. Y1 - 2009/7/1. N2 - Self-expanding stent design systems for carotid artery stenting (CAS) have morphed from nontapered (NTS) to tapered (TS); however, the impact of this change is unknown. We reviewed the outcomes of CAS with these two broad categories of stents in a single-center retrospective review of 308 CAS procedures from May 2001 to July 2007. Nitinol self-expanding TS or NTS coupled with cerebral embolic protection devices were used to treat extracranial carotid occlusive disease. Data analysis included demographics, procedural records, duplex exams, and conventional arteriography. Mean follow-up was 18 months (range 1-69). Restenosis was defined as ...
Carotid endarterectomy is the main treatment for narrowing of the carotid arteries, but sometimes an alternative procedure called carotid artery stent placement may be available.. Its a less invasive procedure than a carotid endarterectomy because theres no need to make a cut in the neck. Instead, a thin flexible tube is guided to the carotid artery through a small cut in the groin. A mesh cylinder (stent) is then placed into the narrowed section of artery to widen it and allow blood to flow through it more easily.. Current guidelines recommend that a carotid endarterectomy should be the first line of treatment for most people. This is because carotid stenting is associated with a higher risk of stroke during the procedure, particularly if its carried out in the first few days after symptoms appear. But its an important alternative for some people who may otherwise be considered to be high risk because of other medical problems.. Find out more about carotid artery stent placement. ...
Carotid endarterectomy is the main treatment for narrowing of the carotid arteries, but sometimes an alternative procedure called carotid artery stent placement may be available.. Its a less invasive procedure than a carotid endarterectomy because theres no need to make a cut in the neck. Instead, a thin flexible tube is guided to the carotid artery through a small cut in the groin. A mesh cylinder (stent) is then placed into the narrowed section of artery to widen it and allow blood to flow through it more easily.. Current guidelines recommend that a carotid endarterectomy should be the first line of treatment for most people. This is because carotid stenting is associated with a higher risk of stroke during the procedure, particularly if its carried out in the first few days after symptoms appear. But its an important alternative for some people who may otherwise be considered to be high risk because of other medical problems.. Find out more about carotid artery stent placement. ...
no one suspected the results from the new study, said Morton Kern, a professor of medicine at UC Irvine. It is one other potential downside to drug-eluting stents, Kern said. The study likely will focus more attention on the process of collateral blood-vessel formation as well as developing new generations of drug-coated stents that dont hinder that process, he said. When drug-coated stents became popular in 2003, they were heralded as a major breakthrough in treating heart disease. The tiny, expandable mesh-like tubes were shown to be far superior to bare-metal stents in preventing the gradual reblockage of arteries, a troubling but seldom fatal process known as restenosis. Drug-coated stents are covered by medicine that slowly dissolves and that can dramatically reduce the formation of scar tissue that can re-block an artery. About 1 million Americans are implanted with stents each year and an estimated 80 percent of those devices are drug-coated. However, in recent months researchers and ...
Use of drug-eluting stents is associated with a lower risk of major cardiovascular events at one year compared to bare metal stents when followed by an individualized course of blood-thinning medication among patients previously thought to be uncertain candidates for drug-eluting stents due to their heightened risk of bleeding or blood clots, according to research presented at the American College of Cardiologys 63rd Annual Scientific Session.
Medical literature has recently focused on very late stent thrombosis (VLST) after drug-eluting stent implantation, while its mechanistic issue was not fully explored in the bare-metal stent (BMS) era. The first case is a 59-year-old man presenting with inferior non-ST-segment elevation myocardial infarction, 4 years after BMS implantation (NIR 3.5/18 mm, Boston Scientific, Galway, Ireland) for a chronic total occlusion lesion in the proximal right coronary artery. Coronary angiograms showed Thrombolysis In Myocardial Infarction (TIMI) flow grade 1 and filling defects in the BMS deployed previously, and massive red thrombi attaching to uncovered stent struts were found by angioscope (Fig. 1,Online Video 1). Thrombectomy and adjunctive balloon angioplasty were performed based on the angioscopic findings, and TIMI flow grade 3 was obtained. The second case is a 71-year-old man who was admitted for a diagnosis of inferior non-ST-segment elevation myocardial infarction 10 years after a treatment ...
Apparatus and methods for stenting are provided comprising a self-expandable stent that is at least partially covered with a biocompatible material configured to prevent dynamic self-expansion of the stent. The biocompatible material is irreversibly expandable by suitable means, for example, a balloon. Thus, the apparatus may be tailored in-vivo to a vessel profile, in a manner similar to a balloon-expandable stent, but maintains the flexibility required for use in tortuous anatomy and in vessels that undergo temporary deformation, in a manner similar to a self-expandable stent. Apparatus is also provided for stenting at a vessel branching, and for localized delivery of therapeutic agents.
Aims: Stent deployment causes endothelial cell (EC) denudation, which promotes in-stent restenosis and thrombosis. Thus endothelial regrowth in stented arteries is an important therapeutic goal. Stent struts modify local hemodynamics, however the effects of flow pertubation on EC injury and repair are incompletely understood. By studying the effects of stent struts on flow and EC migration we identified an intervention that promotes endothelial repair in stented arteries. Methods and Results: In vitro and in vivo models were developed to monitor endothelialization under flow and the influence of stent struts. A 2D parallel-plate flow chamber with 100 μm ridges arranged perpendicular to the flow was used. Live cell imaging coupled to computational fluid dynamic simulations revealed that EC migrate in the direction of flow upstream from the ridges but subsequently accumulate downstream from ridges at sites of bidirectional flow. The mechanism of EC trapping by bidirectional flow involved reduced ...
TY - JOUR. T1 - Drug-eluting balloon versus second generation drug eluting stents in the treatment of in-stent restenosis. T2 - a systematic review and meta-analysis. AU - Liou, Kevin. AU - Jepson, Nigel. AU - Cao, Christopher. AU - Luo, Roger. AU - Pala, Sarvpreet. AU - Ooi, Sze-Yuan. PY - 2016/12. Y1 - 2016/12. N2 - Background In-stent restenosis (ISR) remains a significant mode of stent failure following PCI. The optimal treatment strategy, however, remains undefined and the role of drug-eluting balloons (DEB) in the management of ISR is also unclear.Methods A meta-analysis was performed to compare the efficacy of DEB in the treatment of ISR against second generation drug eluting stents (DES).Results Seven studies comprised of 1,065 patients were included for analysis. The follow-up period ranged from 12-25 months. The use of DEB was associated with an inferior acute gain in minimal luminal diameter (MLD) (0.36, 95% CI: 0.16-0.57 mm), higher late loss in MLD (0.11, 0.02-0.19 mm) and a higher ...
COMMENTS. Coronary stents have been widely used throughout the world to treat severe coronary injuries. A recent analysis of six North-American hospitals demonstrated the growth in the use of stents at a rate of 6.8% per year, in contrast to coronary artery bypass grafting, which is declining at a rate of 1.9% per year (6). In the group of patients treated for ischemic heart disease, 65.4% were treated with PCIs, of which 83% of cases underwent interventions involving a single vessel. Over the last three years, these numbers have not changed significantly. However, it is comprehensible that, for a growing number of cases in which surgery is indicated, the patients have already been treated using endoprostheses. Surgical group reports concerning these patients include the observation that the tissues which surround stents and even the coronary arterial wall itself present with an inflammatory-type reaction not previously identified in patients without stents. The formation of a granuloma-type ...
MAIA, Felipe et al. Comparison of vascular response to different doses and patterns of elution of sirolimus-eluting stents using coronary intravascular ultrasound. Rev. Bras. Cardiol. Invasiva [online]. 2009, vol.17, n.3, pp.320-326. ISSN 2179-8397. http://dx.doi.org/10.1590/S2179-83972009000300008.. BACKGROUND: Positive vascular remodeling after percutaneous coronary intervention (PCI) using drug-eluting stents may be associated to a high dose of an anti-proliferative agent and/or local toxicity of the synthetic polymer. This may lead to late incomplete aposition of the struts, acting as a late/very late thrombosis risk factor. Our objective was to assess the vascular response secondary to sirolimus drug-eluting stent implantation using different doses and patterns of elution by means of serial intravascular ultrasound (IVUS) analysis. METHOD: We assessed 50 patients with low to moderate cardiovascular risk divided into 3 groups according to the sirolimus dose and pattern of elution: group 1, ...
Heart (coronary) artery blockage is a local blocking or narrowing in the arteries on the outer surface of the heart by accumulated deposits of plaque, which is mostly bad cholesterol. Every artery in the body is a blood pipeline. These pipelines get blocked with accumulation of bad cholesterol. When a cardiologist suspects blockage or narrowing of any of these heart arteries he/she will perform an angiography (threading a catheter up a thigh artery to the heart to inject a dye that is visible on X-ray) to view the inside of the arteries. When an area of artery narrowing or blockage is identified a catheter with a balloon is inserted along the same path and inflated at the problem area to open it up. This is called angioplasty. Increasingly stents are placed at these angioplasty sites to keep them open in the long term. In some cases multiple stents are sequentially placed in the same artery. If the area cannot be treated in such a fashion open heart surgery is required which involves opening the ...
AIMS: To provide insight on the patients with long lesions that received multiple, overlapping stents by reporting clinical outcomes, together with a detailed angiographic and intravascular ultrasound analysis of the overlap zone. METHODS AND RESULTS: TAXUS VI is a prospective, multicentre, double-blind, trial, specifically designed to assess outcomes of paclitaxel-eluting stents in longer lesions by randomising 446 patients (1:1) between a drug-eluting TAXUS Express2 Moderate Release (MR) and an uncoated Express2 control stent. Multiple overlapping stents were implanted in 124 patients (27.8%) and are the subject of this report. Clinical, angiographic and IVUS outcomes at nine months were compared in the overlap group for patients receiving the TAXUS Express2 MR stent and the uncoated Express2 stent. In the overlap group, mean lesion length was 25.1 mm with a mean stent length of 43.6 mm. At nine months, TVR was reduced by 94% from 25.0% to 1.6% in the TAXUS patients compared with control (p=|0.0001);
Introduction The use of carotid artery stenting to treat carotid bifurcation stenosis remains a topic of recent investigation and vigorous debate regarding safety and efficacy. Multiple prospective randomized controlled trials have compared carotid endarterectomy (CEA) with carotid artery stenting (CAS) and have shown comparable outcomes in asymptomatic patients. There are certain complications that are more…
DESs have dramatically decreased the need for coronary artery bypass graft (CABG) surgery and repeated PCI. However, late stent thrombosis is a small but important risk with DESs because it is commonly associated with sudden death or acute MI. The clinical occurrence of stent thrombosis after stent implantation can be defined as acute (, 24 h), subacute (1 to 30 d), late (30 d to 1 y), or very late (, 1 y). The clinical diagnosis of stent thrombosis can be defined as definite if proven angiographically or pathologically, probable if an MI occurs in the distribution of the stented artery, or possible if death is unexplained (1). Risk for subacute stent thrombosis is about 1% for both DESs and BMSs, but risk for very late stent thrombosis continues for at least 4 years with DESs at a rate of 2 to 4 events/1000 patients per year (1−3). The presumed cause is delayed or incomplete endothelialization of the stent struts. The unanswered question is whether the decrease in risk for death and MI ...
OBJECTIVE: We sought to characterize the long-term outcomes of patients undergoing intracoronary brachytherapy using Beta- irradiation (Beta-BT). BACKGROUND: Beta-BT is effective in reducing angiographic restenosis as well as target vessel revascularization (TVR) in patients with in-stent restenosis (ISR) after bare-metal stenting (BMS). METHODS: 81 consecutive patients undergoing Beta-BT for ISR (irradiated length 32 [32-54] mm) after BMS in native vessels (n = 79) or saphenous vein grafts (n = 2) between 2001 and 2003 were followed. Major cardiac events (MACE), including cardiac death, nonfatal myocardial infarction (MI), and TVR occurring , 1 year or , 1 year were assessed 5.2 (4.4-5.6) years after the index procedure. RESULTS: During the entire follow-up period, the total MACE rate was 49.4%. Within the first year and at , 1 year, MACE rates were 25.9% and 23.5%, cardiac death occurred in 2.4% and 6.2%, and nonfatal MI in 6.2% and 12.3% for annual cardiac death/MI rates of 8.7% at 32 mm ...
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by Physicians Weekly , Dec 28, 2010. The 37th annual Veith Symposium was held from November 17 to 21 in New York City. The features below highlight some of the news emerging from the meeting. Analyzing Different Stenting Approaches for Restenosis The Particulars: Few studies have compared the use of drug-eluting stents after angioplasty with balloon angioplasty and bare-metal stenting in the treatment of restenosis. The Zilver PTX (Cook Medical, Inc.) is the first drug-eluting stent approved for the superficial femoral artery and is currently under investigation in the United States for use in restenosis. Researchers conducted a study comparing the Zilver PTX drug-eluting stent after angioplasty with balloon angioplasty and bare-metal stenting. Data Breakdown: The study enrolled 479 patients at 56 institutions in the United States, Japan, and Germany, with 241 patients randomized to the Zilver PTX group and 238 to the bare-metal stenting group. Demographics and lesion characteristics were ...
Coronary stents are the most commonly used treatment in the United States to repair narrowed or weakened arteries. The ability to visualize the stent during the stenting procedure and post-surgery is crucial to correctly place the stent with respect to the vessel stenosis, and to identify its position within the vessel wall. Current imaging modalities suffer from low contrast, resolution and/or unfavorable artifacts that can inhibit correct visualization of the stent in the artery. We demonstrated the effectiveness of a combined intravascular photoacoustic and intravascular ultrasound imaging method for high resolution and sufficient contrast imaging of commercial stents with respect to the vessel wall.. ©2009 Optical Society of America. Full Article , PDF Article ...
In the randomized SES bifurcation study (2), the rate of restenosis in the side branch was 21.8%. Incomplete coverage of the side branch was advocated as a possible cause for the high restenosis rate (2,8). In order to guarantee full coverage of the ostium of the side branch, the crush stent technique was introduced (3). Our preliminary experience with the crush stenting technique did not show a clear improvement in the rate of restenosis at the side branch. At that time FKB was not performed routinely when no residual stenosis was observed at ostium of the side branch. Learning from follow-up results led to more frequent performance of FKB. Since January 2003, kissing inflation became standard procedure. In the present study, the restenosis rate of the side branch in the FKB group was 11.1%. Compared to the SES bifurcation study, a 49% relative reduction in the restenosis rate in the side branch was achieved (2). The significant reduction of late loss in the side branch after FKB can be ...