A polyphasic taxonomic approach including analysis of phenotypic, physiological and genotypic characteristics, 16S rRNA gene sequence and DNA-DNA hybridization analysis was used to determine the most consistent affiliation of Pseudomonas pictorum. Pseudomonas pictorum ATCC 23328 T exhibited phenotypic traits of members of the genus Stenotrophomonas including cellular fatty acid composition, quinone and limited range of substrates that could be used. Antibiotic susceptibility and physiological characteristics were determined. The DNA G+C content was 65.7 mol%. Phylogenetic analysis revealed that the type strains of Stenotrophomonas terrae, Stenotrophomonas humi, Stenotrophomonas nitritireducens and Stenotrophomonas acidaminiphila were the nearest relatives (16S rRNA gene sequence similarity of 98.0 to 98.8 %). All the other type strains of species of the genus Stenotrophomonas showed high 16S rRNA gene sequence similarities (96.8 to 97.2 %). DNA-DNA hybridizations revealed 31.0, 32.0, 43.3 and 43.6 %

Résumé: Transfer of Pseudomonas pictorum Gray and Thornton 1928 to genus Stenotrophomonas as Stenotrophomonas pictorum comb. nov., and emended description of the genus Stenotrophomonas Abstract A polyphasic taxonomic approach including analysis of phenotypic, physiological and genotypic characteristics, 16S rRNA gene sequence and DNA-DNA hybridization analysis was used to determine the most consistent affiliation of Pseudomonas pictorum. Pseudomonas pictorum ATCC 23328 T exhibited phenotypic traits of members of the genus Stenotrophomonas including cellular fatty acid composition, quinone and limited range of substrates that could be used. Antibiotic susceptibility and physiological characteristics were determined. The DNA G+C content was 65.7 mol%. Phylogenetic analysis revealed that the type strains of Stenotrophomonas terrae, Stenotrophomonas humi, Stenotrophomonas nitritireducens and Stenotrophomonas acidaminiphila were the nearest relatives (16S rRNA gene sequence similarity of 98.0 to ...

A Gram-stain negative, rod-shaped, aerobic bacterial strain, BII-R7T, was isolated during a study targeting the culture-dependent microbial diversity occurring in bentonite formations from southern Spain. Comparative 16S rRNA gene sequence analysis showed that BII-R7T represented a member of the genus Stenotrophomonas (class Gammaproteobacteria ), and was related most closely to Stenotrophomonas rhizophila e-p10T (99.2 % sequence similarity), followed by Stenotrophomonas pavanii ICB 89T (98.5 %), Stenotrophomonas maltophilia IAM 12423T, Stenotrophomonas chelatiphaga LPM-5T and Stenotrophomonas tumulicola T5916-2-1bT (all 98.3 %). Pairwise sequence similarities to all other type strains of species of the genus Stenotrophomonas were below 98 %. Genome-based calculations (orthologous average nucleotide identity, original average nucleotide identity, genome-to-genome distance and DNA G+C percentage) indicated clearly that the isolate represents a novel species within this genus. Different phenotypic

Sub-acute ruminal acidosis (SARA) is a well-recognized digestive disorder found in particular in well-managed dairy herds. SARA can result in increased flow of fermentable substrates to the hindgut, which can increase the production of volatile fatty acids, alter the structure of the microbial community, and have a negative effect on animal health and productivity. However, little is known about changes in the structure of the microbial community and its relationship with fatty acids during SARA. Four cannulated primiparous (60 to 90 day in milk) Holstein dairy cows were assigned to two diets in a 2 × 2 crossover experimental design. The diets contained (on a dry matter basis): 40% (control diet, COD) and 70% (SARA induction diet, SAID) concentrate feeds. Samples of ruminal fluid and feces were collected on day 12, 15, 17 and 21 of the treatment period, and the pH was measured in the ruminal and fecal samples; the fecal microbiota was determined by pyrosequencing analysis of the V1-V3 region of

Gram-negative, non-spore-forming, rod-shaped bacteria, T7-09T and TR6-08T, were isolated from soil from a ginseng field in South Korea and characterized to determine their taxonomic position. 16S rRNA gene sequence analysis showed that the two isolates shared 99·5 % sequence similarity. Strains T7-09T and TR6-08T were shown to belong to the Proteobacteria and showed the highest levels of sequence similarity to Pseudoxanthomonas broegbernensis DSM 12573T (98·1 %), Pseudoxanthomonas mexicana AMX 26BT (97·4-97·5 %), Pseudoxanthomonas japonensis 12-3T (96·5-96·6 %), Pseudoxanthomonas taiwanensis ATCC BAA-404T (95·7 %) and Xanthomonas campestris ATCC 33913T (96·3-96·5 %). The sequence similarity values with respect to any species with validly published names in related genera were less than 96·5 %. The detection of a quinone system with Q-8 as the predominant compound and a fatty acid profile with C15 : 0 iso as the predominant acid supported the assignment of the novel isolates to the order

SWISS-MODEL Repository entry for A0A5N7SJU0 (A0A5N7SJU0_9GAMM), Probable chemoreceptor glutamine deamidase CheD. Stenotrophomonas sp

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TY - JOUR. T1 - Proteomic analysis of 17β-estradiol degradation by Stenotrophomonas maltophilia. AU - Li, Zhongtian. AU - Nandakumar, Renu. AU - Madayiputhiya, Nandakumar. AU - Li, Xu. PY - 2012/6/5. Y1 - 2012/6/5. N2 - Microbial degradation plays a critical role in determining the environmental fate of steroid hormones, such as 17β-estradiol (E2). The molecular mechanisms governing the microbial transformation of E2 and its primary degradation intermediate, estrone (E1), are largely unknown. The objective of this study was to identify metabolism pathways that might be involved in microbial estrogen degradation. To achieve the objective, Stenotrophomonas maltophilia strain ZL1 was used as a model estrogen degrading bacterium and its protein expression level during E2/E1 degradation was studied using quantitative proteomics. During an E2 degradation experiment, strain ZL1 first converted E2 to E1 stoichiometrically. At 16 h E1 reached its peak concentration, and microbial growth started. At the ...

Stenotrophomonas maltophilia 菌血症で悩むStenotrophomonas maltophilia なお、SM菌血症と略すらしいです。感染症学雑誌 第87巻 第 5 号http://journal.kansensho.or.jp/Disp?pdf=0870050596.pdf先日、私も久々に…

The antibiotic resistance and especially mult-idrug resistance is one of the most important factors for any microorganism survival in nature. In a majority of cases the resistance to antibiotics, as a property is being defined by several genes which are localized in plasmids, transposons and in other mobile genetical elements. As a result, it has been found out that in some native opportunistic pathogenic soil strains of Pseudomonas and Stenotrophomonas, the resistance to different antibiotics is caused by simultaneous presence of different plasmids in cells. Besides, the genes of resistance to various classes of antibiotics of I, II, III generations. They can be localized on one plasmid or in more than one plasmids of current bacterial cell. These plasmids of researched strains of Pseudomonas and Stenotrophomonas are able to stabile replication not only in cells permanently contacting with compatible antibiotic molecules in environment, but also in case of long-term cultivation of bacteria on ...

Stenotrophomonas maltophilia is a human opportunist pathogen, with an environmental origin. Members of the species are common inhabitants of water and soils, including rhizosphere. S. maltophilia can be a plant endosymbiont and is found in animals and washed foods. This Gram-negative bacterium has intrinsic resistance to various classes of antimicrobials. Within the S. maltophilia genome, genes encoding antibiotic inactivating enzymes, multidrug efflux pumps and a quinolone resistance gene contribute to its reduced antibiotic susceptibility. Although a low virulence pathogen, S. maltophilia can cause various infections in susceptible patients. In addition, S. maltophilia isolates present important biotechnological properties, which can be carefully taken into consideration given the pathogenic potential of this microorganism. This research topic examines S. maltophilia from different perspectives, and it includes 11 articles: 1 commentary, 7 primary research articles, and 3 review articles.In the first

Emergence of Stenotrophomonas maltophilia as a nosocomial pathogen is becoming increasingly apparent. Pleiotropic resistance characterizes S. maltophilia. Furthermore, a slow growth rate and an increased mutation rate generate discordance between in vitro susceptibility testing and clinical outcome. Despite original susceptibility, drug-resistant strains of S. maltophilia are often recovered from patients receiving beta-lactams, quinolones, or aminoglycosides. Given the disparity among various in vitro susceptibility methods, this study incorporated a unique pharmacodynamic model to more accurately characterize the bacterial time-kill curves and mutation rates of four clinical isolates of S. maltophilia following exposure to simulated multidose regimens of ceftazidime, ciprofloxacin, gentamicin, and ticarcillin-clavulanate. Time-kill data demonstrated regrowth of S. maltophilia with all four agents. With the exception of ticarcillin-clavulanate, viable bacterial counts at the end of 24 h ...

Stenotrophomonas maltophilia is an environmental bacterium found in the soil, associated with plants and animals, and in aquatic environments. It is also an opportunistic pathogen now causing an increasing number of nosocomial infections. The treatment of S. maltophilia is quite difficult given its intrinsic resistance to a number of antibiotics, and because it is able to acquire new resistances via horizontal gene transfer and mutations. Certainly, strains resistant to quinolones, cotrimoxale and/or cephalosporins-antibiotics commonly used to treat S. maltophilia infections-have emerged. The increasing number of available S. maltophilia genomes has allowed the identification and annotation of a large number of antimicrobial resistance genes. Most encode inactivating enzymes and efflux pumps, but information on their role in intrinsic and acquired resistance is limited. Non-typical antibiotic resistance mechanisms that also form part of the intrinsic resistome have been identified via mutant library

Stenotrophomonas maltophilia is a pathogen that causes infections mainly in immunocompromised patients. Despite increased S. maltophilia isolation from respiratory specimens of patients with cystic fibrosis (CF), the real contribution of the microorganism to CF pathogenesis still needs to be clarified. The aim of the present study was to evaluate the pathogenic role of S. maltophilia in CF patients by using a model of acute respiratory infection in DBA/2 mice following a single exposure to aerosolized bacteria. The pulmonary bacterial load was stable until day 3 and then decreased significantly from day 3 through day 14, when the bacterial load became undetectable in all infected mice. Infection disseminated in most mice, although at a very low level. Severe effects (swollen lungs, large atelectasis, pleural adhesion, and hemorrhages) of lung pathology were observed on days 3, 7, and 14. The clearance of S. maltophilia observed in DBA/2 mouse lungs was clearly associated with an early and ...

Why is this important?. Several cystic fibrosis centres worldwide have reported that Stenotrophomonas maltophilia has become more common. This is a multi-drug resistant, opportunistic bacterium that often causes hospital-acquired infections (e.g. pneumonia). Although, the clinical consequences and importance of S. maltophilia colonisation in people with CFsairways are still debated, it has been recently demonstrated that chronic S. maltophilia infection may increase the risk for pulmonary exacerbations. ...

Stenotrophomonas maltophilia is an emerging nosocomial pathogen associated with opportunistic infections in patients with cystic fibrosis, cancer, and HIV. Adherence of this organism to abiotic surfaces such as medical implants and catheters represents a major risk for hospitalized patients. The adhesive surface factors involved in adherence of these bacteria are largely unknown, and their flagella have not yet been characterized biochemically and antigenically. We purified and characterized the flagella produced by S. maltophilia clinical strains. The flagella filaments are composed of a 38-kDa subunit, SMFliC, and analysis of its N-terminal amino acid sequence showed considerable sequence identity to the flagellins of Serratia marcescens (78.6%), Escherichia coli, Proteus mirabilis, Shigella sonnei (71.4%), and Pseudomonas aeruginosa (57.2%). Ultrastructural analysis by scanning electron microscopy of bacteria adhering to plastic showed flagellalike structures within the bacterial clusters, suggesting

INTRODUCTION Stenotrophomonas maltophilia is an important cause of hospital acquired infection particularly among severely debilitated and immunosuppressed patients. CASE PRESENTATION We report a case of S. maltophilia meningitis in a preterm baby boy after a neurosurgical procedure, successfully treated with trimethoprim-sulfamethoxazole and ciprofloxacin. CONCLUSION This organism should be considered as a potential cause of meningitis and trimethoprim-sulfamethoxazole and ciprofloxacin are a combination that is successful and safe for treating preterm infants.

Antibiotic treatment for Stenotrophomonas maltophilia in people with cystic fibrosis: Cochrane systematic review answers are found in the Cochrane Abstracts powered by Unbound Medicine. Available for iPhone, iPad, Android, and Web.

目次 中文摘要 i 英文摘要 ii 目次 iii 表目次 vii 圖目次 viii 縮寫字對照表 x 前言 1 一、 Stenotrophomonas maltophilia 1 二、 噬菌體療法 2 三、 原核生物的病毒-噬菌體 2 四、 T4-like噬菌體 3 五、 噬菌體T4複製機制 4 六、 研究動機 4 材料方法 6 一、 實驗材料 6 （一）菌種、噬菌體及質體 6 （二）藥品 6 （三）引子（primer） 6 （四）抗生素 6 （五）試劑與緩衝溶液 6 1. 抽取質體DNA試劑 6 2. 噬菌體保存液 6 3. 一般DNA電泳試劑 7 4. 脈衝式電泳（pulsed-field gel electrophoresis）試劑 7 5. RNA之抽取純化試劑 7 6. SDS-PAGE電泳試劑 7 7. 二維電泳（2D-electrohoresis）試劑 8 8. 銀染試劑 8 9. 蛋白質N端定序分析樣品準備之試劑 9 二、 實驗方法 9 （一）細菌培養與保存 9 （二）噬菌體篩選 9 （三）噬菌體培養 9 1. 小量噬菌體培養 9 2. 大量噬菌體培養 10 （四）噬菌體純化 10 ...

Stenotrophomonas (Xanthomonas) maltophilia is an aerobic gram-negative bacillus that is found in various aquatic environments. It is an uncommon pathogen in humans.

2] https://www.ncbi.nlm.nih.gov/pubmed/?term=LONGITUDINAL%20STUDY%20OF%20STENOTROPHOMONAS%20MALTOPHILIA%20ANTIBODY%20LEVELS%20AND%20OUTCOMES%20IN%20CYSTIC%20FIBROSIS% ...

p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class=publication>Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href=http://www.nrbook.com/b/bookcpdf.php>Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...

PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.

1N4O: Role of the disulfide bridge Cys69-Cys238 in class A b-lactamases : a structural and biochemical investigation on the b-lactamase L2 from Stenotrophomonas maltophilia

Biopolymers are making their way into the global market very rapidly owing to their biodegradability and environmentally friendly characteristics. Xanthan, a microbial polysaccharide is being produced by plant pathogens. It is widely used in numerous industrial applications. In the current stu...

God is too wise to be mistaken. God is too good to be unkind. So when you dont understand, when you dont see His plan, when you cant trace His hand, trust His heart. Last May 9, 2017 Papa had his first hospital admission due to Stroke, and he stayed there until May 21. He had no paralysis, only myopathy. During the days that he was in the house, he slowly recovered. He religiously had his physical therapy and did great with his recovery. He got readmitted June 9 due to Pneumonia, Septic Arthritis, Amoebiasis, and Abdominal Bleeding. He was supposed to be discharged on June 29 just in time for his last antibiotic treatment. However, on June 24, he suffered from a Heart Attack so he was placed in ICU. He was cleared for discharge on July 6, with NGT feeding. This was his longest stay at the hospital. On July 31, he had his follow up checkup but while at the clinic, he vomited blood. We did not want to be complacent with his condition so he got admitted for the third time. Within his admission, ...

Kocuria rhizophila ATCC ® 15957™ Designation: FDA strain PCI 1001/E TypeStrain=False Application: Used for the detection of small amounts of penicillin in erythromycin

indicates that this environmental technical ,standard, is dictated under the protection of the Regulation to the Environmental Management Law for the Prevention and Control of Environmental ,Pollution, and is subject to the provisions of these, is mandatory and applies throughout the national territory., The technology and models elimination of an emergency situation on the object containing fire and explosion hazardous and easily flammable liquids on the example of explosion with the subsequent ...

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Members of this family show homology to mononucleotidyl cyclases and to tetratricopeptide repeat (TPR) proteins. Members occur in next to two other markers of ribosomal peptide modification systems. One is a dehydrogenase related to SagB proteins from thiazole/oxazole modification systems. The other is the putative precursor, related to the nitrile hydratase-related leader peptide (NHLP) and nitrile hydratase alpha subunit families. These systems occur in many species of Xanthomonas and Stenotrophomonas, among others ...

Denmark, July 2012 -- Now there is good news to all those who have to handle hydrous oily sludge, both on land and at sea.Faroe Maritime Technic (FMT), have ...

Stenotrophomonas maltophilia is a plant growth-promoter. This bacterium is also implicated in human diseases. Thus, after the use of this bacterium in agriculture, the safety of the final products has to be verified. Due to the ubiquitous presence of S. maltophilia in soil, in this study a massive contamination was simulated to evaluate the growth and safety of Raphanus sativus L.. Different inoculums and soil treatment conditions were tested. Soils were analysed weekly and the radishes at harvest for their microbial loads and presence/persistence of S. maltophilia LMG 6606. The concentration of the bacterium added in the different trials decreased during the first week, but increased thereafter and determined a significant increase of growth parameters of radishes. The addition of S. maltophilia LMG 6606 to non-autoclaved soil enhanced the productivity of radishes. The bacterium did not internalize in the hypocotyls, but colonized the external surface ensuring the safety of

Stenotrophomonas maltophilia-induced pulmonary haemorrhage is considered a fatal infection among haematological patients. The outcome can be explained by the patients immunity status and late diagnosis and treatment. We present the rare case of successful outcome in a 61-year-old female who developed alveolar haemorrhage and acute respiratory distress syndrome 8 days after a chemotherapy session for her acute lymphoblastic leukaemia, in the context of secondary bone marrow aplasia. Stenotrophomonas maltophilia was isolated in sputum culture. The patient benefitted from early empirical treatment with colistin followed by trimethoprim/sulfamethoxazole, according to the antibiogram. Despite a severe initial clinical presentation in need of mechanical ventilation, neuromuscular blocking agents infusion, and ventilation in prone position, the patient had a favourable outcome and was discharged from intensive care after 26 days. Stenotrophomonas maltophilia severe pneumonia complicated with pulmonary

TY - JOUR. T1 - Levofloxacin Efflux and smeD in Clinical Isolates of Stenotrophomonas maltophilia. AU - Chong, So Young. AU - Lee, Kyungwon. AU - Chung, Hae Sun. AU - Hong, Seong Geun. AU - Suh, Younghee. AU - Chong, Yunsop. PY - 2017/3/1. Y1 - 2017/3/1. N2 - Trimethoprim-sulfamethoxazole is the first-line antimicrobial combination for Stenotrophomonas maltophilia infections. However, allergy or intolerance and increasing resistance limit the use of trimethoprim-sulfamethoxazole. Quinolones can be used as an alternative therapeutic option, but resistance can emerge rapidly during therapy. We analyzed the contribution of SmeABC and SmeDEF efflux pumps to levofloxacin resistance in clinical isolates of S. maltophilia. Nonduplicate clinical isolates of S. maltophilia were collected in 2010 from 11 university hospitals (n = 102). Fifty-five levofloxacin nonsusceptible (minimum inhibitory concentration [MIC] ≥4 μg/ml) and 47 susceptible (MIC ≤2 μg/ml) isolates were tested for efflux pump ...

TY - JOUR. T1 - The sul1 gene in Stenotrophomonas maltophilia with high-level resistance to trimethoprim/sulfamethoxazole. AU - Chung, Hae Sun. AU - Kim, Kyeongmi. AU - Hong, Sang Sook. AU - Hong, Seong Geun. AU - Lee, Kyungwon. AU - Chong, Yunsop. N1 - Publisher Copyright: © The Korean Society for Laboratory Medicine.. PY - 2015. Y1 - 2015. N2 - Emerging resistance to trimethoprim/sulfamethoxazole (SXT) poses a serious threat to the treatment of Stenotrophomonas maltophilia infections. We determined the prevalence and molecular characteristics of acquired SXT resistance in recent clinical S. maltophilia isolates obtained from Korea. A total of 252 clinical isolates of S. maltophilia were collected from 10 university hospitals in Korea between 2009 and 2010. Antimicrobial susceptibility was determined by using the CLSI agar dilution method. The sul1, sul2, and sul3 genes, integrons, insertion sequence common region (ISCR) elements, and dfrA genes were detected using PCR. The presence of the ...

The expression of the Stenotrophomonas maltophilia multidrug resistance (MDR) pump SmeDEF is transcriptionally regulated by SmeT (12), a local repressor encoded by the smeT gene, which is located upstream of smeD and which is divergently transcribed. SmeT binds to the intergenic smeT-smeD region, where the promoters of smeT and smeD are located. It has previously been found that a mutation in smeT is responsible for smeDEF overproduction in MDR strain S. maltophilia D457R (1, 12). However, nothing is known about the molecular basis of smeDEF overproduction in clinical S. maltophilia isolates. For that goal, the intergenic smeT-smeD region, which contains both the smeT and smeD promoters, as well as the smeT gene, were cloned from a collection of clinical S. maltophilia strains, 33% of which were SmeDEF overproducers (2), by PCR and sequenced as described previously (12). The strains used in this work are listed in Table 1. The intergenic region and the smeT gene were highly polymorphic (Fig. 1). ...

Stenotrophomonas maltophilia, an opportunistic pathogen usually connected with healthcare-associated infections, is an environmental bacterium. Intrinsic resistance to multiple antibiotics, with different virulence determinants in the last decade classified this bacterium in the group of global multiple drug resistant (MDR) organism. S. maltophilia clinical isolates, were collected from tertiary care pediatric hospital in Belgrade, Serbia to investigate influence of different factors on biofilm formation, kinetics of biofilm formation for strong biofilm producers and effect of trimethoprim-sulfamethoxazole (TMP/SMX) on formed biofilm. Most of the isolates (89.8%) were able to form a biofilm. Analysis of biofilm formation in different growth conditions showed that changing of temeperature and pH had the stronggest effect on biofilm formation almost equally in group of cystic fibrosis (CF) and non-CF strains. TMP/SMX in concentration of 50 μg/ml reduced completely 24 h old biofilms while ...

Stenotrophomonas maltophilia can present as bacteremia, respiratory tract infection, urinary tract infection, soft tissue and wound infections, bone

Exposure to carbapenem and carboxypenicillin or ureidopenicillin during the week before onset of VAP and the severity of disease with regard to respiratory and hematologic failures were independent risk factors for the occurrence of Stenotrophomonas maltophilia-related VAP.

Stenotrophomonas maltophilia is an important opportunistic nosocomial pathogen that shows intrinsic resistance to many antibiotics. This often limits treatment options and can cause lengthy hospital stays. Combination treatments are often used to combat resistance and using natural compounds such as polyphenols could give increased treatment options and even the reuse of antibiotics to which high levels of resistance have been observed. A checkerboard assay was used to determine if any synergy exists between ampicillin and the polyphenol theaflavin against 9 clinical isolates and one control isolate (NCTC 13014) of S. maltophilia. It was discovered that significant synergy (P  0.05) does exist between theaflavin and ampicillin, reducing the mean MIC of ampicillin from 12.5-22.9 µg/mL, in liquid culture, to 3.125-6.25 µg/mL. The FIC index was calculated to be 0.22-0.35 confirming synergy. From these results, significant potential for medical applications can be seen and further investigation ...

TY - JOUR. T1 - The clinical spectrum of Stenotrophomonas (Xanthomonas) maltophilia respiratory infection. AU - Vartivarian, S. E.. AU - Anaissie, E. J.. AU - Kiwan, E. N.. AU - Papadakis, K. A.. PY - 2000/1/1. Y1 - 2000/1/1. N2 - During a 15-month retrospective clinical study in an academic referral-based cancer center, 26 patients with S. maltophilia respiratory tract infections were identified (which were associated with bacteremia in 13 patients). Five of these 26 patients had previously undescribed sinopulmonary involvement. The infections were typically nosocomial. Nine patients with solid tumors had malignant involvement of the respiratory tract (five with obstruction). In two patients, the infection co-existed with pulmonary aspergillosis. Fifteen patients (58%) died of the infection. The factors that correlated with a poor outcome included bacteremic pneumonia, persistent neutropenia, presence of obstruction, development of septic shock or multiple organ dysfunction, and delay in ...

S. maltophilia is naturally resistant to many broad-spectrum antibiotics (including all carbapenems) due to the production of two inducible chromosomal metallo-β-lactamases (designated L1 and L2).[8] This makes treatment of infected patients very difficult. S. maltophilia is ubiquitously present in the environment and impossible to eradicate, which makes prevention also extremely difficult. Sensitivity testing requires nonstandard culture techniques (incubation at 30 °C).[9][10] Testing at the wrong temperature results in isolates being incorrectly reported as being susceptible when they are, in fact, resistant. Disc diffusion methods should not be used, as they are unreliable, and agar dilution should be used instead.[11][12] S. maltophilia is not a virulent organism and removal of the infected prosthesis is frequently sufficient to cure the infection; antibiotics are only required if the prosthesis cannot be removed. Many strains of S. maltophilia are sensitive to co-trimoxazole and ...

What does this mean and reasons for caution?. There were several important observations drawn from this study. The first is that children with CF were found to be at increased risk of acquiring S. maltophilia infection, contrary to previous beliefs that this bacterium was more of a problem in older patients with CF and end stage lung disease. In addition, there has previously been a reluctance to treat patients with CF with oral antibiotics due to the risk of selecting out multi-drug resistant pathogens such as S. maltophilia. However, this study demonstrated that antibiotic therapy may actually be protective against S. maltophilia by slowing lung function decline. ...

The present study describes the S. maltophilia-induced PE of 14 patients who were infected within a period of 4 months at a single hospital because of a contaminated drainage cassette. Described in this study are the clinical characteristics, the effects of antibiotics and PPV, and the final visual acuities after treatments for S. maltophilia as the potential source of the infections.. In the culture-positive group, the median time from surgery to infection was 9.5 days (1-17 days). This time period was comparable with patients in a previous report [13], whose symptoms began between postoperative days 1 and 19. However, in another report [14], endophthalmitis by the same bacteria was fully developed in 26 patients within 2 days after surgery. Based upon the Endophthalmitis Vitrectomy Study (EVS), more virulent microorganisms (e.g., Gram-negative bacteria) were more likely to be diagnosed within 2 days of cataract surgery. However, in our study, as a Gram-negative bacterium, S. maltophilia was ...

In wastewater ,treatment, plants, grit accumulation reduces the ratio of volatile suspended solids/total suspended solids (i.e., reduces biomass in activated ,sludge,), and therefore impairs the efficiency of wastewater ,treatment,. A grit separation module was developed to reduce grit accumulation in such wastewater ,treatment, systems, and a pilot scale ..., Millions of tons of waste activated ,sludge, (WAS) produced from biological wastewater ,treatment, processes cause severe adverse environmental consequences. A better understanding of WAS composition is thus very critical for sustainable ,sludge, management. In this work, the occurrence and distribution of several fundamental ,sludge, constituents were explored in WAS samples from nine full …

Abstract Objective: Recommended combination for the treatment of serious Stenotrophomonas maltophilia infections is ticarcillin-clavulanate and co-trimoxazole (SXT). However, first agent is not available in our country, and the second component may be a matter of antimicrobial resistance or intolerance. Therefore, we aimed to evaluate antimicrobial susceptibility testing results of S. maltophilia and in vitro activity […]

This situation does not come up very often. Two examples would be Pneumocystis jovenii and Stenotrophomonas maltophilia. There is a scarcity of data to guide clinicians in dosing the drug in critically ill patients. This review (free full text) presents a summary of what information we do have, and provides dosing recommendations. ...

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Status i długie ładowanie serwa - napisał w Problemy: Witam mam 2 problemy pierwszy to gdy wpisze w konsoli status to nieważne ze koleś ma nsa i tak pokaże steam_ip i jakies zmyślone id jak to zmienic? A drugi problem jest związany z tym ze po zmianie mapy serwer bardzo długo sie ładuje trzeba czekać 3s na rozpoczęcie łączenia z serwerem. Hosting Gamesol lokalizacja gdańsk amx 1.8.2 o ile sie nie myle.