TY - JOUR. T1 - Human Amniotic Fluid Stem Cells. T2 - Therapeutic Potential for Perinatal Patients with Intractable Neurological Disease. AU - Ochiai, Daigo. AU - Masuda, Hirotaka. AU - Abe, Yushi. AU - Otani, Toshimitsu. AU - Fukutake, Marie. AU - Matsumoto, Tadashi. AU - Miyakoshi, Kei. AU - Tanaka, Mamoru. PY - 2018/12/26. Y1 - 2018/12/26. N2 - Mesenchymal stem cells (MSCs) have generated great interest in the fields of regenerative medicine and immunotherapy because of their unique biological properties. Among MSCs, amniotic fluid stem cells (AFS) have a number of characteristics that make them attractive candidates for tissue engineering and cell replacement strategies, particularly for perinatal medicine. If various neonatal conditions, including birth asphyxia, preterm birth, and congenital abnormalities, which result in long-lasting severe impairments, could be predicted during pregnancy, it would allow collection of small samples of amniotic fluid cells by amniocentesis. In vitro ...

TY - JOUR. T1 - Restoration of functional sperm production in irradiated pubertal rhesus monkeys by spermatogonial stem cell transplantation. AU - Shetty, Gunapala. AU - Mitchell, Jennifer M.. AU - Meyer, Jennifer M.. AU - Wu, Zhuang. AU - Lam, Truong N.A.. AU - Phan, Thien T.. AU - Zhang, Jie. AU - Hill, Lorraine. AU - Tailor, Ramesh C.. AU - Peters, Karen A.. AU - Penedo, Maria C.. AU - Hanna, Carol. AU - Orwig, Kyle E.. AU - Meistrich, Marvin L.. N1 - Funding Information: This work was supported by research grants P01 HD075795 from NIH/NICHD to KO and Cancer Center Support Grant P30 CA016672 from NIH/NCI to the University of Texas MD Anderson Cancer Center. We would like to acknowledge the outstanding work of Leisa Moore who assisted in managing the treatment of the monkeys, sample collections, and animal health issues and also Cathy Ramsey for her valuable assistance in the ovarian stimulation, embryo culture, and ICSI procedures. We sincerely thank Dr Min S. Lee, National Institute for ...

Exp Ther Med. 2017 Jun;13(6):3613-3618. doi: 10.3892/etm.2017.4423. Epub 2017 May 4. Safety of neural stem cell transplantation in patients with severe traumatic brain injury. Wang Z1, Luo Y1, Chen L1, Liang W1. Author information Abstract Neural stem cell (NSC) therapy is a promising treatment for traumatic brain injury (TBI). In addition, mesenchymal stem cells (MSCs) have been investigated for the treatment of TBI due to their functions in neural regeneration and their

The role of exogenous neural stem cells transplantation in cerebral ischemic stroke. - Lukui Chen, Rong Qiu, Lushen Li, Dan He, Haiqin Lv, Xiaojing Wu, Ning Gu

What you wont hear about stem cell technology is that it is a flop. Despite billions of dollars of investment money, it is going nowhere. In fact, what is going on today in research labs doesnt even involve stem cells. You can read more about it at Dr. William Prathers article entitled The Unrealized Potential Of Stem Cell Therapy. [DDD Magazine Oct 2013]. A problem with the stem cell industry is that it becomes so difficult to scuttle a research program that employs so many people at a time when unemployment is a national embarrassment. There are an estimated 6100 full-time employees working in regenerative medicine and over 100 companies involved in stem cell therapies. There were 537 patents filed for stem cell technology in 2007. The National Institutes of Health is reported to have spent $546 million on embryonic stem cell research. [StemCellAction.org] This perpetually promising industry is only in operation as long as it is government subsidized.. Dr. George Daley, a founder of the ...

TY - JOUR. T1 - Complications and risks in hematopoietic stem cell transplant patients.. AU - Smith, L. A.. AU - Wright-Kanuth, M. S.. PY - 2001/3. Y1 - 2001/3. N2 - Hematopoietic stem cell transplantation is a recognized treatment for hematological diseases such as leukemia and lymphoma, certain solid organ tumors, and a limited number of immunologic disorders. The major risks associated with this procedure are infections and development of graft-vs-host disease. Bacterial or viral agents are the most common cause of infections, but fungal and protozoan organisms may also be isolated. Bacterial infections occur most frequently in the first 30 days after transplant, whereas the onset of viral infections usually occurs later during the first three months posttransplant. Studies have demonstrated that there are a variety of predisposing factors that influence the type of infection a patient develops. These include underlying disease, type of chemotherapy regimen, type of antimicrobial and ...

Amniotic fluid is concentrated in hyaluronic acid, stem cells, cytokines, and proteins. These important compounds are the fundamental cells existing in the body. Hyaluronic acid is a naturally occurring liquid found in the knee that helps to cushion the knee and can help sooth any joint.. You may have heard about amniotic fluid injections and wondered if this treatment option was right for you and your situation. The best way to find out is to discuss your condition with one of our physicians so you can be evaluated. These are some common conditions that can benefit from amniotic fluid injections:. ...

Concerns of stem cell transplant patients during routine ambulatory assessment Lisa Kennedy Sheldon,1 Maryum Kazmi,1 Cynthia Klein,2 Donna L Berry31University of Massachusetts Boston, Boston, MA, 2Seattle Cancer Care Alliance, Seattle, WA, 3Phyllis Cantor Center for Research in Nursing and Patient Care Services, Dana-Farber Cancer Institute, Boston, MA, USABackground: Stem cell transplant (SCT) is a treatment choice for many hematological malignancies. There is currently a lack of evidence regarding the self-reported concerns of SCT patients before and after SCT.Aim and design: This exploratory study performed a secondary analysis of self-reported, written concerns of SCT patients before and after transplant to determine patients' concerns.Methods: Content analysis of text box entries of SCT patients collected between 2005 and 2007 at the Seattle Cancer Care Alliance. Text box entries were collected as part of symptom assessment using the Electronic Self-Report Assessment – Cancer instrument.

A team of researchers at the Council for Scientific and Industrial Research (CSIR) is the first in Africa to establish groundbreaking biomedical stem cell technology, which could hold the key to finding cures for some of Africas most prevalent diseases.. The CSIR Department of Biological Sciences Gene Expression and Biophysics Group, led by Dr Musa Mhlanga, success- fully generated the first induced pluripotent stem (iPS) cells in Africa, in December last year.. The iPS cell technology involves inducing adult cells (like skin cells) to revert back to stem cells that can differentiate into specialised cell types. This means that the early stem cells can be programmed to become any type of adult cell, such as skin, heart, brain and blood cells.. Dr Janine Scholefield, one of the key researchers involved in generating iPS cells at the CSIR, was the first biologist in South Africa to record video footage of cardiomyocytes, or heart muscle cells, generated from adult skin cells.. Scholefield was ...

The proposed trial will involve the recruitment of a total of 10 patients.. The cells will be collected from each subject recruited, via bone marrow sampling. CD34+ stem cells will then be isolated and harvested during a process of immuno-selection in accordance with the principles of Good Manufacturing Practice. The CD34+ cells will then be directly infused into the area of the stroke intra-arterially using the middle cerebral artery.. Initially, the investigator will monitor each patient for a period of 6 months post-stem cell infusion. Thereafter, they will revert to their previous treatment regime in the clinic.. Assessment of adverse events will be by physical examination and measurement of laboratory parameters. Assessment of efficacy will be by physical examination and the measurement of laboratory, CT and MRI parameters. ...

Searching for the cost of Stem cell therapy for Autism Treatment in Berlin? Contact Lyfboat to Get an Expert Second Opinion & Personalised Quote for Stem cell therapy for Autism Treatment from the best Stem cell therapy for Autism Treatment hospitals in Berlin. We enable patients to connect, communicate and find quality healthcare for Stem cell therapy for Autism Treatment in Berlin.

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BrainStorm Cell Therapeutics Inc. (OTCBB: BCLI), a leading developer of adult stem cell technologies and therapeutics, announced today that the prestigious Experimental Neurology Journal, published an article indicating that preclinical studies using cells that underwent treatment with Brainstorms NurOwn™ technology show promise in an animal model of Huntingtons disease. The article was published by leading scientists including Professor Melamed and Professor Offen of the Tel Aviv University.. In these studies, bone marrow derived mesenchymal stem cells secreting neurotrophic factors (MSC-NTF), from patients with Huntingtons disease, were transplanted into the animal model of this disease and showed therapeutic improvement.. The findings from this study demonstrate that stem cells derived from patients with a neurodegenerative disease, which are processed using BrainStorms NurOwn™ technology, may alleviate neurotoxic signs, in a similar way to cells derived from healthy donors. This is ...

Stem cell transplantation has the long history of more than 50 years from the first bone marrow transplantation in 1957. From the 2000s, clinical applications of stem cells significantly increased with more diseases and more patients treated with stem cells. Both autologous stem cells and allogeneic stem cells as well as adult stem cells and induced pluripotent stem cells (iPSCs), and both in vitro non-expanded stem cells and in vitro expanded stem cells were clinically applied. For adult stem cells, besides hematopoietic stem cells (HSCs), mesenchymal stem cells (MSCs), neural stem cells, endothelial progenitor cells, limbal stem cells... also were used in the treatment of some diseases. To the year 2015, applications of MSCs have dramatically increased when some MSCs-based drugs that were approved and commercialized in some countries. About iPSCs, Japanese scientists also firstly applied the iPSCs in treatment of ophthalmological diseases. Currently, the European Medicines Agency approved the ...

Treatment modalities have been continuously changing especially for last three decades or so due to new and novel approaches being introduced by the research. Stem cell therapy is one such break through advancement in medical science that has revolutionized treatment strategy to cure many diseases. The old concept some body cells if damaged are irreversibly lost, has been changed with the introduction of stem cell therapy. Now by virtue of stem cells we can regenerate any cell type from pluripotent stem cells (cells having ability to differentiate into any cell type) and the regenerated cells perform function of the damaged cells. Stem cell therapy has been found extremely beneficial in curing a number of diseases and diabetes mellitus is one big example of its utility.. Diabetes mellitus is one of the major health problems and in United States alone; 23.6 million people are suffering from diabetes mellitus that makes 7.8% of total population of America. In addition, 57 million people have ...

This may represent the biggest hope in the field of degenerative diseases like ALS, Prof. Dimitrios Karussis, head of the Hadassah University Medical Centers Multiple Sclerosis Center, said about the clinical trial just completed at Hadassah where stem cells were used to treat Amyotrophic Lateral Sclerosis (ALS).. Even though this was a trial to determine the safety of the technology, early clinical follow up of the patients demonstrated an improvement in breathing and swallowing ability as well as in muscular power. I am very excited about the safety results, as well as the indications of efficacy, Prof. Karussis said. The initial patients who were treated with BrainStorm Cell Therapeutics NurOwn™ stem cell technology experienced no significant side effects in this Phase I/II clinical trial. As a result, Hadassahs ethics and safety committee has now granted BrainStorm approval to proceed with treating additional patients.. ...

Stem cell technologies. We provide care for people suffering from chronic diseases that may be treated with regenerative adult stem cells.

Technology used for isolating, generating, growing and controlling the differentiation of stem cells into specialized cells and the application of stem cell technology for medical and non-medical purposes such as producing meat through cellular agriculture.

Stem cell therapy has huge potential and should be considered as a healing treatment for injuries or organ damage. In addition, systemic stem cell therapy shows promise in treating neurological conditions.. Providing nutritional support for the bodys own stem cells is always a good option, which can be supplemented by using targeted injections of harvested stem cells.. These injections are especially useful when nutritional support does not create enough healing effect or the injured area, such as areas with poor circulation.. Stem cells form the most basic and essential component of the human body. They are capable of differentiating and maturing to other kinds of cell having special functions. Their distinguished characteristic is the fact that they are self-generating, meaning they split to generate additional stem cells.. Latest research about stem cell therapy for regeneration ensures that stem cells can be used for the regeneration of the sick cells. It is known that brain is the organ ...

Stem cell therapy is attracting attention in the field of regenerative medicine and is advancing rapidly. Many recent studies have applied stem cell therapy to treat reproductive system diseases; however, data are not yet available as to whether this therapy shows enhanced therapeutic effects. This paper analyzes recent preclinical studies on stem cell therapy for ovarian dysfunction in several types of animal models. Several clinical trials and pending projects are also discussed. This review will provide a background for developing stem cell therapies to enhance ovarian function.

Stem cell therapy is attracting attention in the field of regenerative medicine and is advancing rapidly. Many recent studies have applied stem cell therapy to treat reproductive system diseases; however, data are not yet available as to whether this therapy shows enhanced therapeutic effects. This paper analyzes recent preclinical studies on stem cell therapy for ovarian dysfunction in several types of animal models. Several clinical trials and pending projects are also discussed. This review will provide a background for developing stem cell therapies to enhance ovarian function.

That is the Stem Cell Arts difference. Our physicians are board-certified pain medicine specialists who are trained and licensed to perform the Regenexx® Family of Stem Cell and Platelet procedures. They have been performing stem cell and platelet rich plasma therapies for more than 10 years. They offer unparalleled expertise and remain unrivaled in research presentations, publications, and academic achievements.. Unfortunately, many other practitioners claiming to be specialists in stem cell therapy have done nothing more than attending a weekend training session.. When it comes to stem cell therapy, experience matters. Dont fall for a quick sales job. Do your homework and you will quickly discover that Stem Cell Arts, an affiliate of National Spine & Pain Centers, is a big leaguer when it comes to safe, effective and experienced treatment of orthopedic conditions using advanced stem cell therapies. ...

Hematopoietic stem cell transplantation (HSCT) is used widely for the treatment of malignant and non-malignant diseases. Advances in transplantation strategies such as modifications to existing transp

Stem cell therapy has emerged as a promising new approach in almost every medicine specialty. This vast, heterogeneous family of cells are now both naturally (embryonic and adult stem cells) or artificially obtained (induced pluripotent stem cells or iPSCs) and their fates have become increasingly controllable, thanks to ongoing research in this passionate new field. We are at the beginning of a new era in medicine, with multiple applications for stem cell therapy, not only as a monotherapy, but also as an adjunct to other strategies, such as organ transplantation or standard drug treatment. Regrettably, serious preclinical concerns remain and differentiation, cell fusion, senescence and signalling crosstalk with growth factors and biomaterials are still challenges for this promising multidisciplinary therapeutic modality. Severe burns have several indications for stem cell therapy, including enhancement of wound healing, replacement of damaged skin and perfect skin regeneration - incorporating skin

BACKGROUND: Due to an ageing population the incidence and prevalence of retinal diseases and visual disabilities will continue to grow. A great number of patients would principally be able to benefit from a stem cell-based therapy. OBJECTIVES: To introduce readers to the terminology and current concepts associated with stem cell therapy in ocular research and to provide an overview of the current status of preclinical and clinical research. MATERIAL AND METHODS: We performed a systematic review of relevant entries on ocular stem cell therapy for retinal diseases in PubMed and ClinicalTrials.gov. Differences between various stem cell types are displayed systematically, followed by a discussion of preclinical studies. Translational aspects are highlighted leading to the first clinical trials, including surgical and ethical facets. RESULTS: In preclinical studies, photoreceptor cell precursors and retinal pigment epithelium (RPE) cells were differentiated and subretinally transplanted into animal models.

Hamilton, Ont. May 29, 2012-Actium Research Inc., (Actium or the Company) Toronto, and McMaster University (McMaster), Hamilton, have entered into a landmark collaboration covering McMasters proprietary adult human stem cell lines, cancer stem cells and the directed differentiation platform developed by Dr. Mick Bhatia and his team at the McMaster Stem Cell and Cancer Research Institute (The Stem Cell Institute). Together these technologies and the expertise at The Stem Cell Institute provide leading edge tools for drug discovery and better treatments for serious illnesses. Actium is a drug discovery and development company targeting two types of stem cells; cancer stem cells to improve survival and health outcomes and normal tissue stem cells to promote healing and address the need for cure in chronic diseases. Actium was founded by Dr. David Young and Helen Findlay. Dr. Bhatia joined as the scientific founder in 2012. The team will put their experience with managing drug discovery ...

The stem cell therapy market appears to have a bright future and recent stem cell therapies in clinical trials have shown much promise. Just a few days ago, the results of a study conducted by the University of Miami showed that stem cell therapy can shrink enlarged hearts by up to 25 percent. Researchers used the patients own bone marrow cells to replace heart scar tissue, which is caused by heart attacks and results in an enlarged heart. The bone marrow cells injected into the damaged heart transformed into heart muscle and also prompted the heart to produce new heart stem cells. After treatment, heart function improved dramatically. In comparison, current therapies for this condition have only been able to reduce size by about 5 percent. With the success of this safety focused trial, there are two more trials planned which will focus on efficacy.. Last year, the Food and Drug Administration (FDA) also approved two embryonic stem cell trials, one by Geron for treatment of spinal cord injury ...

A study published in this months Anesthesiology highlights the potential of cell-based therapies for the treatment of acute lung injury and acute respiratory d

Regenerative medicine uses stem cells and other biological factors to stimulate the bodys own healing response. Caliber Pain™ offers stem cell injections for pain relief and injury healing at our clinic in New York City.

PRP injections work by releasing growth factors which are present in the platelets and they work to regenerate and repair the damaged part of the body. Now the reason why platelets and plasma are used is because as we have already mentioned, they contain growth factors. Growth factors are bioactive proteins which encourage the growth of tissue.. There are thousands of growth factors present in platelets and they work together to initiate and control the natural healing process when there is injury, inflammation or degenerative changes hence robust healing.. Bone Marrow Stem Cell Injections. Stem cells can be defined as blank slate cells. These cells have the remarkable ability to differentiate and develop into various types of cells in the body.. Bone marrow stem cells are one of the most widely used stem cells and these are injected into the body to help repair damaged cells and organs within the body. The process of deriving bone marrow stem cells is quite different from the extraction of ...

Free Online Library: Trial Tests Stem Cell Transplantation Versus Best Available Therapy For MS.(Clinical TRIALS) by Stem Cell Research News; Biological sciences Clinical trials Hematopoietic stem cell transplantation Hematopoietic stem cells Multiple sclerosis Care and treatment Stem cells

Problem: Despite successful axon growth after neural stem cell (NSC) transplantation, recovery of locomotor function is limited. Target: Locomotor training mig …

Before Its News). Stem cell therapies are one of the largest segments of the regenerative medicine market, even when non-therapeutic applications of stem cells are excluded. This rapidly growing sector offers a number of opportunities to both biotechnology and pharmaceutical companies seeking to diversify away from traditional pharmacological compositions and towards a more therapeutic approach, similar to the successful arrival of targeted biologic therapies before the turn of the century. Stem cell therapy represents a very promising platform for clinical advancements in areas where current pharmacological and surgical treatment options are not effective.. These therapies have been in development for human therapeutic use for many decades and there has been steady progress in clinical research, with a few products having already entered the market. Moreover, information leveraged from our robust industry-leading database shows a diverse range of stem cell therapies currently in development ...

Summary: These breakthroughs in stem cell therapy could potentially rejuvenate our damaged organs with induced pluripotent stem cells (iPSCs). Moreover, biotech firms are rushing to bring organ-rejuvenating cell therapies to the marketplace. [This article first appeared on the LongevityFacts.com website. Author: Brady Hartman. ] Recent advances in stem cell therapies could translate into effective treatments for intractable diseases. Stem cells are the repairmen of our bodies. Unlike our ordinary cells, stem cells can divide without limit and create fresh copies of nearly any tissue type to repair damaged organs. While we have an abundance of these repairmen in our youth, we experience stem cell decline as we age.

Stem cell therapy is the future of regenerative medicine, but will stem cell therapy also define the future of healthcare in the United States? In this article, we will explore the benefits of stem cell therapy along with the impact this regenerative revolution will have on healthcare.

Ventricular remodeling and ultimately heart failure are the inexorable consequences of substantial myocardial infarction. In recent years, the understanding that regenerative processes exist at the level of the myocardium has placed stem cell research at center stage in cardiology. Through cellular therapies, the concept of growing heart muscle and vascular tissue and manipulating the myocardial cellular environment has revolutionized the approach to treating heart disease. Unfortunately, however, the vast field of possibilities opened by stem cell therapy has frequently given rise to more questions than answers. A few of these questions include: Which patients with cardiovascular diseases should be considered for stem cell therapy? Which type of stem cell(s) should be used? What quantity and concentration of cells should be administered? By what mechanisms do stem cells engraft, survive, and differentiate? Is the functional and morphological cardiac improvement achieved actively (ie, by ...

Ventricular remodeling and ultimately heart failure are the inexorable consequences of substantial myocardial infarction. In recent years, the understanding that regenerative processes exist at the level of the myocardium has placed stem cell research at center stage in cardiology. Through cellular therapies, the concept of growing heart muscle and vascular tissue and manipulating the myocardial cellular environment has revolutionized the approach to treating heart disease. Unfortunately, however, the vast field of possibilities opened by stem cell therapy has frequently given rise to more questions than answers. A few of these questions include: Which patients with cardiovascular diseases should be considered for stem cell therapy? Which type of stem cell(s) should be used? What quantity and concentration of cells should be administered? By what mechanisms do stem cells engraft, survive, and differentiate? Is the functional and morphological cardiac improvement achieved actively (ie, by ...

BACKGROUND AND OBJECTIVES: Immunohematopoietic stem cell transplantation has curative potential in selected hematologic disorders. Stem cell transplantation was introduced into South Africa in 1970 as a structured experimental and clinical program. In this report, we summarize the demography and outcome by disease category, gender, and type of procedure in patients older than 18 years of age who were seen from April 1995 to December 2002. PATIENTS AND METHODS: This retrospective analysis included 247 individuals over 18 years of age for whom complete data were available. These patients received grafts mostly from peripheral blood with the appropriate stem cell population recovered by apheresis. RESULTS: Patient ages ranged from 20 to 65 years with a median age of 42 years. There were 101 females and 146 males. There were no withdrawals and 63% survived to the end of the study. At 96 months of follow-up, a stable plateau was reached for each disease category. Median survival was 3.3 years (n=6, ...

Pulmonary arterial hypertension (PAH) is an incurable disease characterized by an increase in pulmonary arterial pressure due to pathological changes to the pulmonary vascular bed. As a result, the right ventricle (RV) is subject to an increased afterload and undergoes multiple changes, including a decrease in capillary density. All of these dysfunctions lead to RV failure. A number of studies have shown that RV function is one of the main prognostic factors for PAH patients. Many stem cell therapies targeting the left ventricle are currently undergoing development. The promising results observed in animal models have led to clinical trials that have shown an improvement of cardiac function. In contrast to left heart disease, stem cell therapy applied to the RV has remained poorly studied, even though it too may provide a therapeutic benefit. In this review, we discuss stem cell therapy as a treatment for RV failure in PAH. We provide an overview of the results of preclinical and clinical studies for RV

Stem Cell Therapies of Oklahoma is the best pain management clinic for effective pain relieving treatments in Oklahoma, offering patients a comprehensive range of treatments. We specialize in providing healing factor therapy, PRP therapy and stem cell therapy to suit your specific needs.. Whether youre a professional athlete or just want to remain more active as you get older, were here to help.. At Stem Cell Therapies of Oklahoma, were dedicated to helping people like you improve their lives. Thanks to our specialists in regenerative medicine and certified physicians, we can offer you rejuvenating treatments. As a result, we can help you to live a full life, free of pain and with improved mobility.. ...

PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.

Stem cell therapy is a highly effective treatment to relieve chronic pain and allow the body to heal. An increasing number of doctors and patients now favour stem cell therapy over other treatments for its many advantages and virtually no risks or side effects.. However, many people still carry several myths and misconceptions about the treatment. To help you understand more, here is the truth about the common stem cell therapy myths.. ...

RATIONALE: Drugs used in chemotherapy, such as carboplatin, thiotepa, and etoposide, work in different ways to stop tumor cells from dividing so they stop growing or die. Combining chemotherapy with autologous stem cell transplantation may allow the doctor to give higher doses of chemotherapy drugs and kill more tumor cells. Isotretinoin may be effective in preventing recurrence of glioma. It is not yet known which regimen of chemotherapy plus autologous stem cell transplantation with or without isotretinoin is more effective in treating recurrent high-grade glioma.. PURPOSE: This randomized phase III trial is studying high-dose chemotherapy or intermediate-dose chemotherapy followed by autologous stem cell transplantation to see how well it works compared to high-dose chemotherapy or intermediate-dose chemotherapy followed by autologous stem cell transplantation and isotretinoin in treating young patients with recurrent high-grade glioma. ...

Retinal Pigment Epithelial Cells: Development In Vivo and Derivation from Human Embryonic Stem Cells In Vitro for Treatment of Age-Related Macular Degeneration -- Progenitor Cell Transplantation for Retinal Disease -- Negative Regulation of Endogenous Stem Cells in Sensory Neuroepithelia: Implications for Neurotherapeutics -- Epigenetic Control of Neural Stem Cell Self-Renewal and Specification -- Neural Stem Cells and Neurogenic Niche in the Adult Brain -- Progressing Neural Stem Cell Lines to the Clinic -- Human Neural Stem Cells for Biopharmaceutical Applications -- The Analysis of MicroRNAs in Stem Cells -- Optimized Growth of Human Embryonic Stem Cells -- Potential of Stem Cells in Liver Regeneration -- Cell Transplantation Therapy for Myocardial Repair: Current Status and Future Challenges -- Surgical Stem Cell Therapy for the Treatment of Heart Failure -- Use of Combinatorial Screening to Discover Protocols That Effectively Direct the Differentiation of Stem Cells -- Adult Stem Cell ...

Cytomegalovirus (CMV) infection causes significant morbidity and mortality in the setting of immunodeficiency, including the immune reconstitution phase following allogeneic stem cell transplantation (SCT). We assessed CMV-specific CD4(+) and CD8(+) T-cell responses in 87 HLA-A*0201-positive (A2+) and/or B*0702-positive (B7+) allogeneic stem cell transplant recipients using HLA-peptide tetramer staining and cytokine flow cytometry (CFC) to examine the association of CMV-specific immune reconstitution and CMV antigenemia following SCT. Strong CMV-specific T-cell responses recovered in most subjects (77 of 87, 88%) after SCT. Frequencies of CMV-specific CD8(+) T cells were significantly higher in those subjects who experienced early antigenemia relative to those who did not (2.2% vs 0.33%, P =.0002), as were frequencies of CMV-specific CD4(+) T cells (1.71% vs 0.75%, P =.002). Frequencies of CMV-specific CD8(+) T cells were also higher in subjects experiencing late antigenemia (2.4% vs 0.57%). When we

High-dose chemotherapy and autologous stem cell transplantation involves the administration of high doses of anti-cancer drugs and/or radiation therapy for the purpose of killing cancer cells, followed by the infusion of stem cells to rescue or restore bone marrow blood cell production. It is important to understand that high-dose chemotherapy is the treatment for your cancer and damage to the bone marrow is a side effect. Fortunately, the bone marrow can be rescued or replaced with stem cells. For autologous stem cell transplantation, stem cells are collected from the patient before high-dose chemotherapy is delivered. The stem cells are collected form the bone marrow or peripheral blood, processed, frozen and stored. Since these cells are collected from the patient, they are referred to as autologous stem cells and the term autologous stem cell transplantation refers to either bone marrow or peripheral blood stem cell transplantation.. High-dose chemotherapy and autologous stem cell ...

In recent years, great interest has been devoted to the use of Induced Pluripotent Stem cells (iPS) for modeling of human genetic diseases, due to the possibility of reprogramming somatic cells of affected patients into pluripotent cells, enabling differentiation into several cell types, and allowing investigations into the molecular mechanisms of the disease. However, the protocol of iPS generation still suffers from technical limitations, showing low efficiency, being expensive and time consuming. Amniotic Fluid Stem cells (AFS) represent a potential alternative novel source of stem cells for modeling of human genetic diseases. In fact, by means of prenatal diagnosis, a number of fetuses affected by chromosomal or Mendelian diseases can be identified, and the amniotic fluid collected for genetic testing can be used, after diagnosis, for the isolation, culture and differentiation of AFS cells. This can provide a useful stem cell model for the investigation of the molecular basis of the diagnosed

Bone tissue engineering strategies require cells with high proliferative and osteogenic potential as well as a suitable scaffold to support the development of these as they form new bone tissue. In this study, we evaluated whether the differentiation stage of amniotic fluid stem cells (AFSC) could enhance the regeneration of critical sized femoral defects in a rat model. For this purpose, AFSC were seeded onto a starch-poly(ε-caprolactone) (SPCL) scaffold and were cultured in vitro in osteogenic culture media for different periods of time in order to obtain: i) undifferentiated cells, ii) cells committed to the osteogenic phenotype and iii) osteoblast-like cells. In vitro results indicate that AFSC were considered to be osteogenically committed by the end of week 2 and osteoblastic-like after week 3 in culture. Constructs composed of AFSC-SPCL scaffolds from each differentiation stage were implanted into critical sized femoral defects. The quality of new tissue formed in the defects was ...

TY - JOUR. T1 - Combined NgR vaccination and neural stem cell transplantation promote functional recovery after spinal cord injury in adult rats. AU - Xu, C. J.. AU - Xu, L.. AU - Huang, L. D.. AU - Li, Y.. AU - Yu, P. P.. AU - Hang, Q.. AU - Xu, Xiao-Ming. AU - Lu, P. H.. PY - 2011/2. Y1 - 2011/2. N2 - Aims: After spinal cord injury (SCI), there are many adverse factors at the lesion site such as glial scar, myelin-derived inhibitors, cell loss and deficiency of neurotrophins that impair axonal regeneration. Therefore, combination therapeutic strategies might be more effective than a single strategy for promoting functional recovery after SCI. In the present study, we investigated whether a Nogo66 receptor (NgR) vaccine, combined with neural stem cell (NSC) transplantation, could promote better functional recovery than when NgR vaccine or NSCs were used alone. Methods: Adult rats were immunized with NgR vaccine at 1 week after a contusive SCI at the thoracic level, and the NSCs, obtained from ...

Autologous stem cell transplantation for the treatment of neuroblastoma in Korea.: Autologous stem cell transplantation (ASCT) for the treatment of high-risk ne

Read Docosahexaenoic acid (DHA) enhances the therapeutic potential of neonatal neural stem cell transplantation post-Traumatic brain injury, Behavioural Brain Research on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.

Autologous stem cell transplant harvests your own stem cells from your body, stores them and injects them back into your body following another potentially harmful treatment like, chemotherapy or radiation. The stem cells are collected through a process called Bone Marrow Aspiration. International Healthcare Providers can guide you through the minefield of researching and selecting a healthcare solution tailored to your needs. We will work with you at every stage to help you better understand the current state of the research and offer you peace of mind, comfort, and security.. You have choices and control when it comes to taking care of your health. International Healthcare Providers can bring you premium access to the best healthcare in North America and help you find a specialist who will walk you through an autologous stem cell transplant.. Autologous stem cell transplants are used in the treatment of a variety of cancers as well as treating musculoskeletal issues. If you think this ...

Dr. Vanden Berge has recently stared performing stem cell injections in his office here in Stephenville. Stem cell injections are being used in the treatment of many conditions including osteoarthritis. For patients who are not ready for surgical intervention, stem cell therapy may offer an alternative. At VB Orthopaedics, stem cells are harvested from your own bone marrow and injected into the affected joint or around ligaments and tendons. The process is completed in the office, and most patients report relief in joint pain, swelling, and stiffness.. Can stem cells improve your joint pain without surgery?. ​. As we age, our bodies can deteriorate leading to pain, stiffness, and swelling. Osteoarthritis is one of the most common chronic joint conditions, but there are numerous ailments that stem cells are used to treat. If you are suffering from joint pain, are stem cells an option for you?. ​. What are stem cells?. ​. Stem cells come from your own body, and they are found mainly in bone ...

1. Volarevic V, Ljujic B, Stojkovic P. et al. Human stem cell research and regenerative medicine: present and future. Br Med Bull. 2011;99:155-168 2. Volarevic V, Erceg S, Bhattacharya SS. et al. Stem cell-based therapy for spinal cord injury. Cell Transplant. 2013;22:1309-1323 3. Turner L, Knoepfler P. Selling Stem Cells in the USA: Assessing the Direct-to-Consumer Industry. Cell Stem Cell. 2016;19:154-157 4. Smith AG. Embryo-derived stem cells: of mice and men. Annu Rev Cell Dev Biol. 2001;17:435-462 5. Zhang X, Stojkovic P, Przyborski S. et al. Derivation of human embryonic stem cells from developing and arrested embryos. Stem Cells. 2006;24:2669-2676 6. Thomson JA, Itskovitz-Eldor J, Shapiro SS. et al. Embryonic stem cell lines derived from human blastocysts. Science. 1998;28:1145114-1145117 7. Reubinoff BE, Pera MF, Fong CY. et al. Embryonic stem cell lines from human blastocysts: somatic differentiation in vitro. Nat Biotechnol. 2000;18:399-404 8. De Trizio E, Brennan CS. The business of ...

Ulcerative colitis (UC) is a chronic inflammatory bowel disease with continuous or recurrent symptoms. A 42-year-old male patient with intermittent diarrhe

Long-term reduction in peripheral blood HIV type 1 reservoirs following reduced-intensity conditioning allogeneic stem cell transplantation. J Infect Dis. 2013 Jun 01; 207(11):1694-702 ...

The prognosis of brain tumors in children has improved for the last 2-3 decades. However, the prognosis remains dismal in patients with relapsed tumors. The outcome for infants and young children is also poor. For younger children, the ability to use of radiotherapy (RT) is very limited because of the unacceptable long-term adverse effects of RT. The prognosis is also not satisfactory when a large residual tumor remains after surgery or when leptomeningeal seeding is present at diagnosis. In this context, a strategy using high-dose chemotherapy and autologous stem cell transplantation (HDCT/autoSCT) has been explored to improve the prognosis of recurrent or high-risk brain tumors. It was found that at least some patients with relapsed tumors can be salvaged with HDCT/autoSCT. For infants and young children, it was possible to avoid or defer RT until 3 years of age while maintaining or improving survival rates. Investigators also have explored the efficacy of HDCT/autoSCT in patients with newly ...

2 Basic principles of human embryonic stem cells D. Ilic, D. Stevenson, H. Patel and P. Braude, Kings College London School of Medicine UK Abstract: Despite increasing interest in other … - Selection from Progenitor and Stem Cell Technologies and Therapies [Book]

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Outcomes for elderly patients with acute myeloid leukemia (AML) remain poor with standard therapies. Historically this age group has been excluded from treatment with allogeneic stem cell transplantation (allo-SCT) due to worries of excessive treatment related morbidity and mortality. However, transplantation outcomes have dramatically improved in the last decade due to the widespread use of less ablative conditioning regimens, improved supportive care, and improved patient selection based on prognostic tools such as the hematopoietic cell transplant specific comorbidity index. These have all led to an increasing acceptance of allo-SCT as a potential treatment modality in elderly patients with AML. This review addresses current strategies for patient selection and efficacy data for allo-SCT in elderly patients with AML.. DOI: http://dx.doi.org/10.3126/jaim.v1i1.5840. Journal of Advances in Internal Medicine. 2012; 1(1): 43-49. ...

University of Wisconsin Hospital and Clinics Hematopoietic Stem Cell Transplant Program Clinical Standard Operating Policies and Procedures TITLE: Stress Ulcer Prophylaxis for Hematopoietic Stem Cell Transplant Patients University of Wisconsin Hospital and Clinics Hematopoietic Stem Cell Transplant Program Clinical Standard Operating Policies and Procedures TITLE: Stress Ulcer Prophylaxis for Hematopoietic Stem Cell Transplant Patients Purpose: Establish guidelines for appropriate interventions to prevent stress ulcer in patients undergoing Hematopoietic Stem Cell Transplantation and to prevent complications associated with stress ulcer prophylaxis. Principle: Use of medications to prevent stress ulcer in Hematopoietic Stem Cell Transplant patients may be appropriate since high dose chemoradiation places the patients at high risk for disruption of gastrointestinal mucosal integrity; however, agents utilized and treatment duration should be limited. Proton Pump Inhibitors (PPIs) such as ...

Background. The role of single vs double autologous stem cell transplantation (ASCT) for newly diagnosed (ND) multiple myeloma (MM) continues to be debated in the novel agent era. Methods. The phase III EMN02/HO95 study was designed to administer 3-4 cycles of bortezomib-cyclophosphamide-dexamethasone as induction therapy for NDMM and afterwards to randomize eligible patients to receive (randomization 1, R1) standard-dose intensification treatment with bortezomib-melphalan-prednisone (VMP) for four 42-day cycles or high-dose intensification treatment with melphalan at 200 mg/m2 (HDM) plus ASCT. A second randomization to receive or not receive consolidation therapy was planned after the intensification phase, followed by lenalidomide maintenance in both arms. In centers committed to a double ASCT policy, patients were randomized (1:1:1) to receive VMP or single ASCT (ASCT-1) or two sequential courses of HDM (administered 2 to 3 months apart) plus double ASCT (ASCT-2) in order to prospectively ...

Allogeneic stem cell transplantation (allo-SCT) has become an essential treatment modality for individuals with high-risk severe myeloid leukemia (AML) and is usually also less than investigation for gentle tissue sarcomas. a heterogeneous inhabitants of polyclonal Testosterone levels cells writing both organic great (NK) phenotype and useful properties of NK cells (Pievani et al., 2011). CIK cells can end up being effectively extended from peripheral 1009119-65-6 supplier bloodstream (PB), BM mononuclear cells and umbilical cable bloodstream by addition of interferon (IFN), triggering antibody described against Compact disc3 and interleukin DC42 (IL)-2 (Lu and Negrin, 1994; Thorne et al., 2006). We lately utilized IL-15 for additional CIK cell account activation and enlargement (Rettinger et al., 2012). We could present that IL-15-turned on CIK cells possess an elevated anti-leukemic potential likened to regular IL-2-turned on CIK cells. Furthermore, our customized process allowed us to shorten ...

Whether these cells are as versatile as embryonic stem cells remains to be determined, said Atala, but the current finding is certainly encouraging.. Atala stopped short of calling the cells pluripotent, which means the ability to form many cell types. He said while the cells meet some of the characteristics of pluripotency, such as versatility, they do not form tumors when implanted in animals, which is also considered a characteristic. The fact that the amnion cells are less likely to form tumors may be one advantage that they have over embryonic stem cells in their potential for clinical use.. Co-researchers were Alessandro Valli, Ph.D., Margit Rosner, student, Christiane Fuchs, MSc., Nicol Siegel, MSc., and Helmut Dolznig, Ph.D., from the Medical University of Vienna, Colin E. Bishop, Ph.D., from Wake Forest, and Ulrike Mädel, student, and Wilfried Feichtinger, M.D., from Wunschbaby Zentrum, in Vienna, Austria.. About the Wake Forest Institute for Regenerative ...

Firstly, we analyzed hAFC samples for the expression of germ cell markers; in agreement to previous reports [11], we observed a consistently high expression of OCT4 and CD133. However, when we examined additional markers we did not observe expression of genes specific to germ cell differentiation. In this regard, it was reported that hAFCs had the ability to form embryoid bodies (EBs) when cultured under conditions without anti-differentiation factors and without contact to feeder cells. Moreover, the formation of such three-dimensional multicellular aggregates was accompanied by a decrease in stem cell marker expression and by the induction of differentiation into different cell lineages [23]. Hence herein hAFCs kept under a stem cell culture system yielded a high number of clones that when cultured in suspension without anti-differentiation factors, spontaneously formed multicellular EBs and harbored high differentiation potential. Moreover, when we cultured EBs in the presence of germ cell ...

Liu Hong-tao,Liu Dai-hong,Huang Xiao-jun,et al. Treatments of disease relapse after allogeneic stem cell transplantation focusing on donor lymphocyte infusion[J]. CHINESE MEDICAL JOURNAL,2013,126(22):4380-4388 ...

TY - JOUR. T1 - Cardiosphere-derived cells from pediatric end-stage heart failure patients have enhanced functional activity due to the heat shock response regulating the secretome. AU - Kaushal, Sunjay. AU - Sharma, Sudhish. AU - Mishra, Rachana. AU - Simpson, David L.. AU - Wehman, Brody. AU - Colletti, Evan J.. AU - Deshmukh, Savitha. AU - Datla, Srinivasa Raju. AU - Balachandran, Keerti. AU - Guo, Yin. AU - Chen, Ling. AU - Siddiqui, Osama T.. AU - Kaushal, Shalesh. PY - 2015/4/1. Y1 - 2015/4/1. N2 - We have demonstrated that human neonatal cardiosphere-derived cells (CDCs) derived from the young are more regenerative due to their robust secretome. However, it is unclear how the decompensated pediatric heart impacts the functional activity of their CDCs. Our aim was to characterize the potency of pediatric CDCs derived from normal functioning myocardium of control heart disease (CHD) patients to those generated from age-matched end stage heart failure (ESHF) patients and to determine the ...

March 26, 2013. Scientific Statement of the Philippine Heart Association on Stem Cell Therapy for Heart Disease. • Responding to the growing interest on stem cell therapy (SCT) for heart disease, the Philippine Heart Association recently held an Intercouncil Summit on Stem Cell Therapy in Heart Disease to gather and present objective data on this cell-based therapy in heart disease.. • An extensive review of clinical trials on SCT in patients with acute myocardial infarction (AMI) and left ventricular dysfunction (LVD) was performed. Based on three systematic reviews (most notably involving The Cochrane Library 2012 ) involving 33 randomized controlled trials, bone marrow SCT showed no effect in reducing mortality and morbidity after AMI during short term (six months) and long-term follow ups (1-5 years) over conventional treatment such as angioplasty.. • However, bone marrow SCT improved short-term and long-term left ventricular function (or LV function) and reduced left heart size ...

The long-term goal of this research is to improve survival for patients after allogeneic stem cell transplantation by limiting graft-versus-host disease (GvHD)...

BACTERIAL BLOOD STREAM INFECTIONS NEGATIVELY IMPACT ON OUTCOME OF PATIENTS TREATED WITH ALLOGENEIC STEM CELL TRANSPLANTATION: 6 YEARS SINGLE-CENTRE EXPERIENCE

BACTERIAL BLOOD STREAM INFECTIONS NEGATIVELY IMPACT ON OUTCOME OF PATIENTS TREATED WITH ALLOGENEIC STEM CELL TRANSPLANTATION: 6 YEARS SINGLE-CENTRE EXPERIENCE

Autologous Stem Cell Transplant: An autologous stem cell transplant utilizes the patients own stem cells, while allogeneic transplants involve the collection of stem cells from a donor. High-dose chemotherapy and autologous stem cell transplant had not been widely used to treat myelodysplastic syndrome because stem cells collected from the patient with myelodysplasia were thought to be abnormal. However, many patients are not able to undergo an allogeneic stem cell transplant due to side effects of the procedure or the absence of an matched donor.. Results of a clinical trial have shown that autologous stem cell transplants may provide long-term survival for patients with MDS or AML secondary to MDS. Patients involved in this trial were first treated with initial moderate-dose chemotherapy followed by one round of high-dose chemotherapy. After high-dose chemotherapy, patients with a matched donor were treated with an allogeneic transplant and those with no matched donor were treated with an ...

An autologous stem cell transplant is different from an allogeneic stem cell transplant, which uses stem cells from a matching donor. Learn more.

TY - JOUR. T1 - Patients mobilizing large numbers of CD34+ cells (super mobilizers) have improved survival in autologous stem cell transplantation for lymphoid malignancies. AU - Bolwell, B. J.. AU - Pohlman, B.. AU - Rybicki, L.. AU - Sobecks, R.. AU - Dean, R.. AU - Curtis, J.. AU - Andresen, S.. AU - Koo, A.. AU - Mineff, V.. AU - Kalaycio, M.. AU - Sweetenham, J. W.. PY - 2007/9/1. Y1 - 2007/9/1. N2 - The cellular composition of an autologous graft may influence autologous stem cell transplantation (ASCT) outcome. Etoposide (VP) plus filgrastim (G) frequently mobilizes high numbers of CD34+ cells for autologous transplantation. We investigated whether patients collecting high numbers of CD34+ cells (super mobilizers) have a better outcome than other patients. We reviewed 350 consecutive adult patients with NHL or Hodgkins lymphoma receiving an ASCT from January 1994 to December 2005, mobilized with VP+G. Super mobilizers were defined as collecting a minimum of 8 × 106 CD3+ cells/kg. ...

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This study is aimed to determine the effect of transplantation of neural progenitor cells (NPCs) isolated from fetal hippocampus on cognitive functions of experimental animals after short-term global cerebral ischemia. NPCs were isolated from hippocampus of FVB-Cg-Tg(GFPU)5Nagy/J mice, transgenic by the GFP. Ischemic brain injury in FVB wild type mice was modeled by bilateral occlusion of the common carotid arteries for 20 min. GFP-positive NPCs were stereotaxically transplanted into the hippocampus of experimental animals in 24 hours after ischemia-reperfusion. Cognitive functions were evaluated using Morris water maze. Results of this study showed that global short-term cerebral ischemia resulted into cognitive impairments in mice. Stereotaxic transplantation of NPCs promoted the cognitive function recovery in experimental animals after ischemic brain injury. Thus, the data indicates that transplantation of NPCs may have a therapeutic effect in treating of ischemic stroke.. Full Text PDF ...

At the University of Chicago Medicine, we offer the full range of blood and bone marrow stem cell transplantation options. We are recognized for our expertise in alternative donor transplantation; relapse prevention and treatment; transplantation for older adults; and focused, disease-specific care.

Purpose: : To determine if bone marrow-derived stem cells (BMSC) have the capacity in vitro and in vivo to express retinal pigment epithelial (RPE)-like markers. Methods: : In vitro, mouse Sca-1+ GFP+ cells of bone marrow origin were used in coculture with adult mouse RPE cells. The coculture in a 1:1 ratio was performed with and without cell-cell-contact for up to 3 weeks. Mouse fibroblasts served as a control. Immunocytochemical analysis was performed using monoclonal antibodies (mAbs) against specific RPE markers - cytokeratin, RPE65, MITF - as well as non-RPE markers - opsin (photoreceptors) and glial fibrillary acidic protein (GFAP; glia). In vivo, sodium iodate (NaIO3) was used to damage the RPE. For this study, C57BL/6 mice were injected i.v. with 35 mg/kg NaIO3 followed by the subretinal (s.r.) injection of 3x104 Sca-1+ GFP+ BMSC on day 3. The mice were sacrificed on days 7, 14, 21, and 28 after transplantation. Whole eye flat mounts (FM) were prepared and examined for GFP+ cells under a ...

A lot of patients are walking the halls of the Stem Cell Transplantation and Cellular Therapy Center these days. They are part of the Motivated & Moving program designed to encourage patients undergoing stem cell transplantation to increase their physical activity.. Kelly Faltus, advanced practice nurse in the inpatient unit, says the exercise performed through the program helps promote a sense of well-being and reduces the fatigue common among transplant recipients.. Before we started the program, patients were getting out and walking, but it wasnt consistent, Faltus says. Sometimes they were too tired, or the nurses were busy and werent reminding them. So we wanted to find a fun way to encourage them to exercise on their own.. The result was the creation of the incentive-based program, in which patients earn rewards based on how much they exercise each week.. ...

by APFLI , Aug 23, 2006 , Stem Cell - Definitions / History / Statistics. Stem Cell Information : The official National Institutes of Health resource for stem cell research Turning Blood into Brain: New Studies Suggest Bone Marrow Stem Cells Can Develop into Neurons in Living Animals, November 30, 2000 http://www.ninds.nih.gov/news_and_events/press_releases/pressrelease_bloodtobrain_113000.htm Transplanted Neural Stem Cells Migrate Throughout the Abnormal Brain, Reduce Disease Symptoms June 07, 1999 http://www.ninds.nih.gov/news_and_events/press_releases/pressrelease_neural_stem_cells_060799.htm Cultured Neural Stem Cells Reduce Symptoms in Model of Parkinsons Disease July 20, 1998 http://www.ninds.nih.gov/news_and_events/press_releases/pressrelease_stemcells_072098.htm Stem Cells and Stem Cell Transplantation - MedLine Plus http://www.nlm.nih.gov/medlineplus/stemcellsandstemcelltransplantation.html Clinical Trials.gov: Stem Cell Transplantation (NIH) ...

Heart failure is a leading cause of death in Canada. As part of the ongoing IMPACT-CABG clinical trial to treat advanced heart failure, physicians at the Peter Munk Cardiac Centre performed the first cardiac stem cell transplant in Ontario using stem cells derived from the patients own bone marrow, isolated completely within the operating room, and implanted into the heart at the time of coronary bypass surgery. Researchers hope that stem cell therapy may be developed into a novel treatment for the 50,000 Canadians diagnosed each year with advanced heart failure. The first patient to receive this type of stem cell therapy, James Culross, a 67-year-old man from Etobicoke, will be discharged this week after 2.83 million stem cells were injected into seven sites where his heart had been damaged by a heart attack in November 2011. The stem cells were injected following coronary artery bypass graft (CABG) surgery, by a multi-disciplinary team led by Dr. Terrence Yau, Cardiac Surgeon and Director of ...