1. The effects of food intake and the fatty acid composition of the diet on the hepatic stearoyl-CoA desaturase activity of obese-hyperglycaemic (ob/ob) mice were investigated. 2. Obese mice fed on a commercial mouse diet, ad libitum, had 6.5-fold more activity per liver cell than had lean mice. 3. On a diet containing 14% corn oil the activity was 65% less in obese mice and 62% less in lean mice compared with animals fed on the commercial diet. 4. Feeding with 14% saturated fat in the diet doubled the activity in lean mice compared with those on the commercial diet, but had no effect on the activity in obese mice. 5. Obese mice fed on the corn-oil diet contained a higher proportion of linoleic acid in the liver lipids than did lean mice fed on the commercial diet, but the acyl-CoA desaturase activity was 125% higher than in the lean mice. 6. Limiting the food intake of obese mice by pair-feeding with lean mice decreased their acyl-CoA desaturase activity when the animals were fed on the ...

Background: The paucity of effective therapeutic agents for hepatocellular cancer (HCC) underscores the critical need for more effective therapeutic strategies. Recent studies indicate lipid biosynthesis and desaturation is required for HCC survival. Targeting these may prove beneficial because such changes contribute to therapeutic resistance. Stearoyl CoA desaturase (SCD1), a key mediator of fatty acid (FA) biosynthesis and rate-limiting in conversion of saturated fatty acids (SFAs) to mono-unsaturated fatty acids (MUFAs), is upregulated in HCC and many other cancers. As such, we therapeutically targeted a novel lipogenic tumor survival mechanism mediated by SCD1 as a means to combat the chemoresistance associated with HCC. In so doing, we evaluated a novel lead SCD1 inhibitor in HCC.. Methods: Paraffin embedded patient HCC tissues were examined for SCD1 expression. Using combined computational and synthetic chemistry approaches, we synthesized four novel specific SCD1 inhibitors with SSI-4 ...

Validation of SteatoNet.a) Simulation of fasting condition, b) Simulation of stearoyl CoA desaturase (SCD) knockout. The lipogenic diet was simulated until time

GlaxoSmithKline is developing GSK 1940029, a stearoyl CoA desaturase 1 inhibitor, as a topical gel for the treatment of acne vulgaris. Phase I clinical

TY - JOUR. T1 - Stearoyl-CoA desaturase-1 impairs the reparative properties of macrophages and microglia in the brain. AU - Bogie, Jeroen F. J.. AU - Grajchen, Elien. AU - Wouters, Elien. AU - Corrales, Aida Garcia. AU - Dierckx, Tess. AU - Vanherle, Sam. AU - Mailleux, Jo. AU - Gervois, Pascal. AU - Wolfs, Esther. AU - Dehairs, Jonas. AU - Van Broeckhoven, Jana. AU - Bowman, Andrew P.. AU - Lambrichts, Ivo. AU - Gustafsson, Jan-Ake. AU - Remaley, Alan T.. AU - Mulder, Monique. AU - Swinnen, Johannes. AU - Haidar, Mansour. AU - Ellis, Shane R.. AU - Ntambi, James M.. AU - Zelcer, Noam. AU - Hendriks, Jerome J. A.. PY - 2020/5. Y1 - 2020/5. KW - CHOLESTEROL EFFLUX. KW - MYELIN PHAGOCYTOSIS. KW - FATTY-ACIDS. KW - ELECTROSPRAY-IONIZATION. KW - STIMULATED MACROPHAGES. KW - DEFICIENCY PROTECTS. KW - GENE-EXPRESSION. KW - FOAM CELLS. KW - MICE. KW - REMYELINATION. U2 - 10.1084/jem.20191660. DO - 10.1084/jem.20191660. M3 - Article. VL - 217. JO - Journal of Experimental Medicine. JF - Journal of ...

Fingerprint Dive into the research topics of Inhibition of stearoyl-coA desaturase selectively eliminates tumorigenic Nanog-positive cells: Improving the safety of iPS cell transplantation to myocardium. Together they form a unique fingerprint. ...

Introduction:. Stearoyl-CoA desaturase 1 (SCD1) has been introduced as a novel therapeutic target in malignancies, including breast cancer. The present study was designed to investigate the effect of pharmacologic inhibition of SCD1 on fatty acid profile in tissue explant culture of human breast cancer, and also to compare these effects with those in adjacent non-neoplastic breast tissue.. Methods:. Paired samples of tumor and adjacent non-cancerous tissue were isolated from twelve patients with infiltrating ductal breast cancer, explant cultured in vitro, exposed to a highly selective SCD1 inhibitor CAY10566, and investigated with respect to fatty acid composition by gas liquid chromatography (GLC). Anti-proliferative and cytotoxic effects were evaluated by quantification of lactate dehydrogenase (LDH) release and by sulforhodamine B (SRB) measurement.. Results:. In the breast cancer tissue, levels of monounsaturated fatty acids (MUFA, P < 0.001) and arachidonic acid (20:4n-6; P < 0.001) were ...

These studies establish a critical role for SCD in the generation of body fat. The deletion of the SCD1 gene resulted in global changes in gene expression and altered metabolic activity that can account for the loss of body fat.. Genes encoding enzymes that participate in fatty acid oxidation were up-regulated in the SCD1−/−mice. CPT-1, ACO, VLCAD, and FIAF are known targets of PPARα (27, 28) and contain PPARα response regions in their promoters (28). Because PPARα mRNA is unchanged (data not shown), the up-regulation of enzymes of fatty acid β-oxidation in the SCD1−/− mice must be downstream of PPARα transcription. Thus, it is possible that loss of SCD1 function results in an increase in the concentration of a PPARα activator, perhaps a lipid ligand. The contents of saturated fatty acids (C16:0 and C18:0) are increased, whereas the contents of the polyunsaturated fatty acids of the n-6 and n-3 are not changed in the liver of the SCD1−/− mice (8, 10). One possible mechanism for ...

Lipids play important roles in many cellular processes including membrane synthesis, energy storage, and cell signaling. Each of these processes is critical for the proliferation and survival of tumor cells. The composition of the lipids available for carrying out processes such as membrane biogenesis and lipid-mediated signaling is determined by the availability of the lipids and their precursors from the extracellular space, combined with the capacity of the cell to carry out de novo lipid synthesis and modification. The synthetic pathways for the creation of specialized lipid molecules are highly complex and utilize numerous enzymes with unique functions.. SCD1 is a widely studied enzyme that carries out a critical step in the production of MUFAs from SFA precursors. SFA and MUFA are the most abundant fatty acids in mammalian cells, and the ratio of SFA to MUFA can affect membrane fluidity and the activity of membrane associated receptors and enzymes (23, 24).. A growing body of evidence has ...

PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.

Invitrogen™ eBioscience™ Human sCD44var (v6) Platinum ELISA Kit 96 tests Invitrogen™ eBioscience™ Human sCD44var (v6) Platinum ELISA...

Intensely marbled Wagyu raised in North Texas. American Wagyu is the ideal combination of the exceptional intermuscular marbling of purebred Japanese Wagyu and the intense meaty flavor of traditional American cattle. The diet of the Kobe Beef Wagyu Beef is one of the most factors that ensures the tenderness and quality of the Beef Steak. Certified American Purebred Wagyu from the Morgan Ranch is Americas finest gourmet beef. Our aim is to provide you with the highest quality beef products, free of added hormones or antibiotics, to ensure you are … Whitney crossbred these bulls with Angus and other American breeds to improve the quality of domestic herds. Finding the perfect harmony between seasoning and meat, hardwood and smoke, time and temperature is a gift, a talent, a craftsmanship that few are able to master. Here at Kay Wagyu we utilize all the genetic testing offered by the American Wagyu Association, including SCD (Stearoyl COA Dataturase) and tenderness. Distributors, retailers and ...

Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (PubMed:12815040, PubMed:16443825). Required for the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides (By similarity).

Oxygen and nutrient limitation are common features of the tumor microenvironment and are associated with cancer progression and induction of metastasis. The inefficient vascularization of tumor tissue also limits the penetration of other serum-derived factors, such as lipids and lipoproteins, which can be rate limiting for cell proliferation and survival. Here we have investigated the effect of hypoxia and serum deprivation on sterol regulatory element-binding protein (SREBP) activity and the expression of lipid metabolism genes in human glioblastoma multiforme (GBM) cancer cells. We found that SREBP transcriptional activity was induced by serum depletion both in normoxic and hypoxic cells and that activation of SREBP was required to maintain the expression of fatty acid and cholesterol metabolism genes under hypoxic conditions. Moreover, expression of stearoyl-CoA desaturase, the enzyme required for the generation of mono-unsaturated fatty acids, and fatty acid-binding protein 7, a regulator of glioma

Metabolic syndrome, a collection of related abnormalities like hypertension, obesity, insulin resistance, and excess cholesterol, poses a major risk for developing heart disease and diabetes. Individuals with a genetic predisposition to high cholesterol can be especially vulnerable to metabolic syndrome, but researchers have now found that blocking the enzyme stearoyl-CoA desaturase-1, which helps synthesize unsaturated fatty acids, greatly improves the profile of FH-mice affected by metabolic syndrome.

Lung cancers is certainly the most regular form of cancers. causing from SCD blockade had been completely reversed by either oleic (18:1n-9), palmitoleic acidity (16:1n-7) or cis-vaccenic acidity (18:1n-7) showing that cis-MUFA are essential elements for cancers cell growth. Additionally, co-treatment of cells with CVT-11127 and CP-640186, a particular acetylCoA carboxylase (ACC) inhibitor, do not really potentiate the development inhibitory impact of these substances, recommending that inhibition of SCD1 or ACC impacts a equivalent focus on important for cell growth, most likely MUFA, the common fatty acidity item in the path. This speculation was additional strengthened by the remark that exogenous oleic acidity reverses the anti-growth impact of SCD and ACC inhibitors. Cediranib Finally, exogenous oleic acidity refurbished the internationally reduced amounts of cell fats in cells going through a blockade of SCD activity, suggesting that energetic lipid activity is definitely needed for the ...

Alcohol is inflammatory and can aggravate a damaged gut. But theres another reason that it hampers your success on SCD, paleo or AIP - one I had to learn the hard way.

NSC 14613 is an inhibitor of the stearoyl-coA desaturase 1 (SCD1), which is able to selectively eliminate hPSCs. Buy Dehydrogenase inhibitor NSC 14613 from AbMole BioScience.

Stearoyl-CoA Desaturase 1 Exercise Determines the Upkeep of DNMT1-Mediated DNA Methylation Patterns in Pancreatic β-Cells Metabolic stress, akin to lipotoxicity, impacts the DNA methylation … ...

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Abstracts of the 34th International Society for Animal Genetics (ISAG) Conference: Xian, China, 27 de julio - 1 de agosto de 2014, p. 93- ...

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The aim of this study was to determine variation in the activity of stearoyl-CoA desaturase enzyme and endogenous precursors of unsaturated fatty acids in cows milk during the grazing season. The study was carried out in 10 certified organic farms The major criterions of choosing organic farms to the experiment were as follows: obtaining certificate for at least 5 years and abidance of the organic farming standards, possessing a herd of Black and White Polish Holstein-Friesian cows (numbering more than 30 cow. The highest concentrations of CLA cis9, trans11 isomer, TVA and LA in milk fat has been reported in June, slightly lower in July and August. While the lowest level has been recorded in May, at the beginning of grazing period. Significant correlations between MUFA and SCD (r2= 0.828 p

We hypothesized that supplementing finishing diets with palm oil would promote adipogenic gene expression and stearoyl-CoA desaturase (SCD) gene expression in subcutaneous (s.c.) and intramuscular (i.m.) adipose tissues of feedlot steers. Eighteen Angus and Angus crossbred steers were assigned to three groups of 6 steers and fed a basal diet (control), with 3% palm oil, or with 3% soybean oil, for 70 d, top-dressed daily. Tailhead s.c. adipose tissue was obtained by biopsy at 14 d before the initiation of dietary treatments and at 35 d of dietary treatments. At slaughter, after 70 d of dietary treatment, tailhead s.c. adipose tissue and i.m. adipose tissue were obtained from the longissimus thoracis muscle. Palm oil increased plasma palmitic acid and soybean oil increased plasma linoleic acid and α-linolenic acid relative to the initial sampling time. Expression of AMP-activated protein kinase alpha (AMPKα) and peroxisome proliferator-activated receptor gamma (PPARγ) increased between the ...

Monounsaturated fatty acids (MUFA) have been viewed as either beneficial or neutral with respect to health; however, recent evidence suggests that MUFA may be associated with obesity and cardiovascular disease. Sex differences in MUFA composition have been reported in both rats and humans that may be mediated by sex hormones. Therefore, differences in fatty acid and enzyme expression were examined in male and female rats. HepG2 cells treated with 17β-estradiol, progesterone and testosterone (0, 10, 30 and 100 nM), and ovariectomized female rats with hormone implants (sham, no treatment, estradiol, progesterone, and estradiol plus progesterone) examined the role of sex hormones in MUFA metabolism. MUFA concentrations were determined by gas chromatography. The mRNA and protein expression of stearoyl-CoA desaturase and elongase 6, key enzymes involved in MUFA biosynthesis, were measured by real-time PCR and immunoblotting, respectively. Elongase 6 protein expression was higher in females as ...

Conversely, normal insulin responsiveness results in increased D5D and D6D activity as does a caloric restriction diet. Stearoyl-CoA desaturase (SCD) is the rate-limiting enzyme catalyzing the synthesis of monounsaturated fatty acids (MUFAs), primarily oleate (18:1; a physiologically significant omega-9 fatty acid) and palmitoleate (16:1). This latter class of enzyme is involved primarily with the remodeling of phospholipids. Humans express three MOGAT genes identified as MOGAT1, MOGAT2, and MOGAT3. Additional regulatory steps in triglyceride formation are the reactions catalyzed by the microsomal phosphatidic acid phosphatase and diglyceride acyltransferase. In the mammalian myocardium, an active triglyceride synthesis pathway is operating, (re)esterifying activated fatty acids from endogenous or exogenous sources, with the glycolytically derived three-carbon intermediates dihydroxyacetone-phosphate and glycerol-3-phosphate by the so-called Kennedy pathway. Ninja Nerds,Join us in this video ...

Purpose: Testosterone deficiency is commonly associated with obesity, metabolic syndrome, type 2 diabetes and their clinical consequences - hepatic steatosis and atherosclerosis. The testicular feminised (tfm) mouse (non-functional androgen receptor and low testosterone) develops fatty liver and aortic lipid streaks on a high-fat diet whereas androgen replete XY littermate controls do not. Testosterone replacement ameliorates these effects, although the underlying mechanisms remain unknown. Methods: We compared the influence of testosterone on the expression of regulatory targets of glucose, cholesterol and lipid metabolism in muscle, liver, abdominal subcutaneous (SAT) and visceral adipose tissue (VAT). Results: Tfm mice displayed significantly reduced GLUT4 in muscle and glycolytic enzymes in muscle, liver and SAT but not VAT. Lipoprotein lipase required for fatty acid uptake was only reduced in SAT, enzymes of fatty acid synthesis were increased. Stearoyl-CoA desaturase-1 that catalyses oleic ...

Arabidopsis stearoyl ACP desaturase: a fatty acid desaturase modulates the activation of defense signaling pathways in plants; amino acid sequence in first source

My first year on SCD involved a lot of trial and error and cutting out certain foods. I discovered nuts didnt agree with me in large amounts. Too many vegetables, even if cooked, would aggravate digestive issues. Too much fruit or honey and I was a raving lunatic craving carbs (even dreaming about them!). So I spent a lot of time cutting out food and narrowing down to a base safe diet.. The second year on SCD, after reading articles from a number of sources like the Weston A. Price Foundation, I started to change my thinking. Rather than focusing on cutting out food, I realized I needed to add more nutrient-dense food to my diet. I could cut out all the food that irritated my already damaged gut, but until I got enough nutrients to repair and heal that damaged gut, I would not be able to truly be healthy. SCD alone is a very nourishing diet, but focusing on a few key foods can really bring about a lot of healing.. I was surprised when I had been on SCD for over a year and stopped taking B ...

Im very much struggling to stick with the SCD diet as I find that I am not getting enough calories from it, especially as I improve and am engaging in more...

The LEGENDplex™ HU Immune Checkpoint Panel 1 Mix and Match Beads are individual capture beads for 12-targets including: sCD25 (IL-2Ra), 4-1BB, sCD27, B7.2 (CD86), Free Active TGF-b1, CTLA-4, PD-L1, PD-L2, PD-1, Tim-3, LAG-3, and Galectin-9. The beads are recommended for use with each other and the f

Shop sn-2 acyl-lipid omega-3 desaturase ELISA Kit, Recombinant Protein and sn-2 acyl-lipid omega-3 desaturase Antibody at MyBioSource. Custom ELISA Kit, Recombinant Protein and Antibody are available.

SCD Notice! You can disabled this sidebar on SCD settings in the admin Wordpress dashbord under Woocommerce plugin. You are using the SCD free variant, this allow only 3 currencies conversion. Go to the SCD premium variant, or just open this link to suscribe for free SCD Premium 14 days trial. The free variant is free for lifetime. No license is required. Therefor only 3 currencies (Euro/EUR, Australia Dollar/AUD, India Rupee/INR) are available there, additionally to the default currency.. The premium variant has the whole bunch of currencies available worldwide. Please be aware that if you install the premium variant, you shall keep this free variant installed and activated too!. Click here to have a detailed summary video about our plugin. ...

|jats:p|Fatty acid desaturases (FADS) catalyze the formation of unsaturated fatty acids and have been related to insulin sensitivity (IS). FADS activities differ between tissues and are influenced by genetic factors that may impact the link to IS. Genome-wide association studies of δ-5-desaturase (D5D), δ-6-desaturase (D6D) and stearoyl-CoA desaturase-1 (SCD) activities (estimated by product-to-precursor ratios of fatty acids analyzed by gas chromatography) in serum cholesterol esters (n = 1453) and adipose tissue (n = 783, all men) were performed in two Swedish population-based cohorts. Genome-wide significant associated loci were evaluated for associations with IS measured with a hyperinsulinemic euglycemic clamp (n = 554). Variants at the FADS1 were strongly associated with D5D in both cholesterol esters (p = 1.9 × 10−70) and adipose tissue (p = 1.1 × 10−27). Variants in three further loci were associated with D6D in cholesterol esters (FADS2, p = 3.0 × 10−67; PDXDCI, p = 4.8 × 10−8;

Involved in the biosynthesis of highly unsaturated fatty acids (HUFA) from the essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3) precursors, acting as a fatty acyl-coenzyme A (CoA) desaturase that introduces a cis double bond at carbon 6 of the fatty acyl chain. Catalyzes the first and rate limiting step in this pathway which is the desaturation of LA (18:2n-6) and ALA (18:3n-3) into gamma-linoleate (GLA) (18:3n-6) and stearidonate (18:4n-3), respectively (PubMed:12713571). Subsequently, in the biosynthetic pathway of HUFA n-3 series, it desaturates tetracosapentaenoate (24:5n-3) to tetracosahexaenoate (24:6n-3), which is then converted to docosahexaenoate (DHA)(22:6n-3), an important lipid for nervous system function (By similarity). Desaturates hexadecanate (palmitate) to produce 6Z-hexadecenoate (sapienate), a fatty acid unique to humans and major component of human sebum, that has been implicated in the development of acne and may have

A cDNA encoding the plastid ω-3 fatty acid desaturase was isolated from a tobacco (Nicotiana tabacum cv. SR1) leaf cDNA library. The amino terminal extension of the deduced amino acid sequence of this clone had a characteristic feature of the transit peptides of plastid-destined proteins. Northern analysis indicated that the mRNA corresponding to this cDNA was present in leaves, but was not detected in roots. Responses to wounding of the plastid and microsome ω-3 desaturase genes were investigated in tobacco leaves. The mRNA level of the plastid ω-3 desaturase gene increased to about 2-fold that of unwounded controls at 12 h after a wounding treatment. On the other hand, the mRNA level of the microsome ω-3 desaturase gene remained constant in the wounded leaves. Linolenic acid contents of major leaf polar lipids increased by wounding. These results indicate that wounding enhances the accumulation of the plastid ω-3 desaturase mRNA, and increases the conversion of linoleic acid to linolenic ...

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Animals and experimental design: rat studies. Forty 10-week-old male Sprague-Dawley rats (Charles River Breeding Laboratories) were housed in individual cages and subjected to a standard light/dark cycle (lights on at 0600). One week before the pancreatic insulin clamp protocols (Figure 1B), catheters were placed in the right internal jugular veins and left carotid arteries as previously described (35, 36). Five and two days before the pancreatic clamp, rats received a single i.p. injection of either Scd1 or control (SCR) ASO (100 mg/kg of body weight). This dose of ASO was designed to achieve a robust downregulation of Scd1 expression in the liver with just 2 i.p. injections. Rats were fed an SC diet (Purina Mills Inc., Cat. No. 5001) until 3 days before the clamp; then the animals were switched to a highly palatable diet (Purina Mills Inc., Cat. No. 9389) generated by supplementation of the SC diet with 10% lard (Supplemental Table 3). An additional group of animals fed on SC throughout the ...

Overview of insulin resistance what it means why it occurs and tests ordered when insulin resistance is suspected. Energy Drink Death 2017 diabetic Living; Eat This Recipes; Cinnamon Rolls. What Should Your Blood Sugar Level Be in the Morning? High blood sugar levels during pregnancy can cause your baby to be larger than average at birth Modulation of the transcription of genes encoding acyl-CoA synthetase and stearoyl-CoA desaturase-1. My Gestational Diabetes Diet Diary. Acinar cell carcinoma g.. How do I make a healthier pie crust? is a frequent question from readers. Energy Drink Death 2017 Executive summary of our review of the UST400 system Diabetes , Diabetes diet Please note that this menu is not intended for patients with type 1 diabetes How to stay healthy while having fun in Presentation Why Research Networks in England? Diabetes Research Network NE London local coverage and set up If youve got five foil mini loaf pans weve got a recipe to fill them withlike these rich moist ...

Stearoyl-coenzyme A desaturase 1 (SCD1) catalyzes the conversion of stearate (18:0) to oleate (18:1n-9) and of palmitate (16:0) to palmitoleate (16:1), which are key steps in triglyceride synthesis in the fatty acid metabolic network. This study investigated the role of SCD1 in fatty acid metabolism in HepG2 cells using SCD1 inhibitors and stable isotope tracers. HepG2 cells were cultured with [U-(13)C]stearate, [U-(13)C]palmitate, or [1,2-(13)C]acetate and (1) DMSO, (2) compound CGX0168 or CGX0290, or (3) trans-10,cis-12 conjugated linoleic acid (CLA ...

Effect of dietary fats on desaturase activities and the biosynthesis of fatty acids in rat-liver microsomes.: Four groups of rats were fed diets containing 15%

LMills, I cook the carrots a long time. They say to do it 4 hours when you start out on the diet. I throw mine in the crock pot with whatever meat Im cooking, so they get nice and soft. Then I smash them up good before eating them. Some people even puree them, but I only do that before adding them back into a soup broth. The green beans, zucchini (minus the skin), and spinach I just steam until tender, and then chew it really good too. I havent tried peas yet. According to the stages at pecanbread.com, theyre a stage 3 food, and Ive only just started stage 2. However, my dad (has crohns, but is not on the diet) eats them minus the shells. Its kind of funny, because I have a bird and she picks the shells off of her peas too! As for the condiments, youre supposed to make your own. However, I found some mustard with legal ingredients (the house brand at Safeway appears to be good). Same with Spectrums Organic Mayonnaise. However, companies dont have to list ingredients under 2%, so there ...

Sodium Stearoyl Glutamate is a surfactant. It is sold by Ajinomoto under the tradename Amisoft HS11-P. Ajinomoto describes this ingredient as an anionic surfactant produced from L-Glutamic acid (an amino acid) and plant-derived palm fatty acid. Extremely hypoallergenic and well suited as a emulsifier. The pH is similar to that of the skin, therefore, it is very mild to the skin. Natural and environmentally friendly.. ...

Sodium Stearoyl Glutamate is a surfactant. It is sold by Ajinomoto under the tradename Amisoft HS11-P. Ajinomoto describes this ingredient as an anionic surfactant produced from L-Glutamic acid (an amino acid) and plant-derived palm fatty acid. Extremely hypoallergenic and well suited as a emulsifier. The pH is similar to that of the skin, therefore, it is very mild to the skin. Natural and environmentally friendly.. ...

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As a sugar additive, fructose is widely used in processed foods and beverages. Excessive fructose consumption can cause hepatic steatosis and dyslipidemia, leading to the development of metabolic syndrome. Recent research revealed that fructose-induced nonalcoholic fatty liver disease (NAFLD) is related to several pathological processes, including: (1) augmenting lipogenesis; (2) leading to mitochondrial dysfunction; (3) stimulating the activation of inflammatory pathways; and (4) causing insulin resistance. Cellular signaling research indicated that partial factors play significant roles in fructose-induced NAFLD, involving liver X receptor (LXR)α, sterol regulatory element binding protein (SREBP)-1/1c, acetyl-CoA carboxylase (ACC), fatty acid synthase (FAS), stearoyl-CoA desaturase (SCD), peroxisome proliferator-activated receptor α (PPARα), leptin nuclear factor-erythroid 2-related factor 2 (Nrf2), nuclear factor kappa B (NF-κB), tumor necrosis factor α (TNF-α), c-Jun amino terminal kinase (JNK

Preliminary evidence suggests that exenatide (Byetta®) may have several beneficial direct and indirect effects on NAFLD and liver lipid metabolism. Ad hoc analysis of phase III studies has shown that exenatide treatment is associated with improvement and normalization of alanine aminotransferase (ALT), a marker of liver injury, and that this effect is most pronounced in those with the greatest weight loss. In addition, treatment of leptin deficient ob/ob mice with exenatide reduced weight, liver lipid content, serum ALT and liver lipid peroxidation. Additional evidence suggests that the effects of exenatide on the liver are not simply a result of weight loss, but rather due to direct effects on the liver. Hepatocytes express GLP-1 receptors that are responsive to both GLP-1 and exenatide. Furthermore, exenatide treatment of ob/ob mice or isolated hepatocytes reduces mRNA for stearoyl-CoA desaturase-1 (SCD-1) and SREBP-1c, which would be expected to reduce DNL.. Based upon this data, we ...

Preliminary evidence suggests that exenatide (Byetta®) may have several beneficial direct and indirect effects on NAFLD and liver lipid metabolism. Ad hoc analysis of phase III studies has shown that exenatide treatment is associated with improvement and normalization of alanine aminotransferase (ALT), a marker of liver injury, and that this effect is most pronounced in those with the greatest weight loss. In addition, treatment of leptin deficient ob/ob mice with exenatide reduced weight, liver lipid content, serum ALT and liver lipid peroxidation. Additional evidence suggests that the effects of exenatide on the liver are not simply a result of weight loss, but rather due to direct effects on the liver. Hepatocytes express GLP-1 receptors that are responsive to both GLP-1 and exenatide. Furthermore, exenatide treatment of ob/ob mice or isolated hepatocytes reduces mRNA for stearoyl-CoA desaturase-1 (SCD-1) and SREBP-1c, which would be expected to reduce DNL.. Based upon this data, we ...

Determination of fatty acid acquisition routes in an isogenic model with either Akt or Ras pathway activation demonstrated that Akt induces de novo fatty acid synthesis, whereas Ras decreases it. This was most evident for the mono-unsaturated fatty acid oleate (C18:1), of which 96% was produced de novo in Akt-driven cells but only 57% in Ras-driven cells. We confirmed that Akt pathway activation leads to elevated levels of stearoyl-CoA desaturase 1 (SCD1), a key enzyme in the synthesis of oleate, and that Ras pathway activation leads to increased uptake of exogenous lipids. We hypothesized that SCD1 inhibition would therefore be particularly toxic to the Akt-driven cells. We confirmed that Akt activated cells were significantly more sensitive to SCD1 inhibition than those with Ras activation. Growth of Ras-driven cells was unaffected by SCD1 inhibition for multiple doublings, after which the cells stopped growing. We found that growth inhibition coincided with depletion of lysolipids in the ...

(HealthDay)-Monounsaturated fatty acids (MUFAs) may reduce inflammation and improve insulin sensitivity in adipose tissue, according to research published online Jan. 27 in Diabetes.

New Report On Global Monounsaturated Fatty Acid Market Status and Future Forecast 2015-2024 added to Orbisresearch.com store which has 142 pages and available for purchase at US $ 4500.

Flower-like particles (FLPs) with hierarchical surface architectures have recently attracted considerable attention due to their potentially wide application range. Hitherto, nearly all FLPs were fabricated using inorganic compounds, while versatile organic polymers have not received sufficient attention yet. Herein, we show the construction of novel organic, polymeric FLPs with diameters of 2.5-5 μm using cellulose stearoyl esters (CSEs) by means of the crystallization of side chains. CSEs with degrees of substitution of approximately 3 were transformed into FLPs during the gradual precipitation of polymer chains from the mixture of their solutions in dichloromethane (DCM) and a nonsolvent, which is driven by the evaporation of DCM. Ordered petal-like nanostructures were formed on the particle surface through the crystallization of side chains. Finally, partially crystalline FLPs containing lamellar structures were obtained. Moreover, the formation process was strongly affected by the ...