Background== * Staphylococcus lugdunensis is a coagulase-negative staphylococcus with unusual pathogenicity resembling that of S. aureus,ref>Taha L, Stegger M, and Soderquist B. Staphylococcus lugdunensis: antimicrobial susceptibility and optimal treatment options, European Journal of Clinical Microbiology & Infectious Diseases, May 2019. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6647525/ Accessed 21 December 2020.],/ref> *A [[Gram Positive Bacteria]] *Causes [[endocarditis]], [[meningitis]], and [[Skin and Soft Tissue Infections]] Antibiotic susceptibility pattern of 540 Staphylococcus lugdunensis isolates tested with the disc diffusion method:,ref>Taha L, Stegger M, and Soderquist B. Staphylococcus lugdunensis: antimicrobial susceptibility and optimal treatment options, European Journal of Clinical Microbiology & Infectious Diseases, May 2019. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6647525/ Accessed 21 December 2020.],/ref> {, class=wikitable sortable ,- ! Antibiotic !! No. ...

This study was conducted to determine the frequency of Staphylococcus lugdunensis in different clinical samples. Out of 690 clinical samples, a total of 178 coagulase negative staphylococci (CoNS) isolates were recovered. CoNS were identified as 10 different species; 22 isolates belonged to Staphylococcus lugdunensis. Two specific genes for S. lugdunensis were used (tanA gene and fbl gene) to confirm identification. Both of these specific genes were detected in 15 (68.1%) of 22 isolates that were identified phenotypically. The results of oxacillin MIC showed that 7 of the 15 (46.6%) S. lugdunensis isolates were oxacillin resistant. The antibiotic susceptibility testing against 16 antibiotics showed that resistance rates were variable towards these antibiotics. Eight of fifteen S. lugdunensis isolates (53.3%) were β-lactamase producer. Results of molecular detection of mecA gene found that mecA gene was detected in 6 (40%) of 15 S. lugdunensis. All of these 6 isolates (S1, S2, S3, S4, S5, and ...

TY - JOUR. T1 - From clinical microbiology to infection pathogenesis. T2 - How daring to be different works for Staphylococcus lugdunensis. AU - Frank, Kristi L.. AU - Del Pozo, José Luis. AU - Patel, Robin. PY - 2008/1. Y1 - 2008/1. N2 - Staphylococcus lugdunensis has gained recognition as an atypically virulent pathogen with a unique microbiological and clinical profile. S. lugdunensis is coagulase negative due to the lack of production of secreted coagulase, but a membrane-bound form of the enzyme present in some isolates can result in misidentification of the organism as Staphylococcus aureus in the clinical microbiology laboratory. S. lugdunensis is a skin commensal and an infrequent pathogen compared to S. aureus and S. epidermidis, but clinically, infections caused by this organism resemble those caused by S. aureus rather than those caused by other coagulase-negative staphylococci. S. lugdunensis can cause acute and highly destructive cases of native valve endocarditis that often ...

Deoxyribonucleic acid relatedness studies (S1 nuclease method) showed that 23 unidentified Staphylococcus strains form two homogeneous genomic species related 1 to 9% to 24 type strains representing known Staphylococcus species. These new species were named Staphylococcus lugdunensis and Staphylococcus schleiferi. Strains of S. lugdunensis were susceptible to novobiocin, produced a fibrinogen affinity factor, and failed to produce coagulase, heat-stable nuclease, and staphylokinase. S. lugdunensis strains differed from S. hominis (the phenotypically closest species) by production of ornithine decarboxylase and the fibrinogen affinity factor. The guanine-plus-cytosine content of the deoxyribonucleic acid was 32 mol%. The type strain is N860297 (= ATCC 43809). Strains of S. schleiferi were susceptible to novobiocin, produced a heat-stable nuclease and a fibrinogen affinity factor, and failed to produce coagulase and staphylokinase. S. schleiferi strains differed from S. aureus by production of an

Staphylococcus lugdunensis is a species of coagulase-negative staphylococcus (CoNS) that causes serious infections in humans akin to those of S. aureus. It was often misidentified as S. aureus, but this has been rectified by recent routine use of matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) in diagnostic laboratories. It encodes a diverse array of virulence factors for adhesion, cytotoxicity, and innate immune evasion, but these are less diverse than those encoded by S. aureus. It expresses an iron-regulated surface determinant (Isd) system combined with a novel energy-coupling factor (ECF) mechanism for extracting heme from hemoproteins. Small cytolytic S. lugdunensis synergistic hemolysins (SLUSH), peptides related to phenol-soluble modulins of S. aureus, act synergistically with β-toxin to lyse erythrocytes. S. lugdunensis expresses a novel peptide antibiotic, lugdunin, that can influence the nasal and skin microbiota. Endovascular infections ...

Staphylococcus lugdunensis is a coagulase-negative member of the genus Staphylococcus, consisting of Gram-positive bacteria with spherical cells that appear in clusters.[citation needed] It was first described in 1988 after being differentiated through DNA analysis. Its name comes from Lugdunum, the Latin name for Lyon, France, where the organism was first isolated. Colonies of S. lugdunensis are usually hemolytic, sticky, yellow or tan, and about 2-4 mm in diameter after a 48-hour incubation. They also can have a characteristic sweet, hay-like odor.[citation needed] S. lugdunensis may produce a bound coagulase (that is, the enzyme is bound to the cells), a property it shares with S. aureus, but unlike S. aureus, it does not produce a free coagulase. In the laboratory, it can give a positive slide-coagulase test but a negative tube-coagulase test. It is fairly easy to identify because, unlike the great majority of staphylococci, it decarboxylates ornithine and is positive for pyrrolidonyl ...

C. Dubos, J Lebeurre, S Dahyot, M. Pestel-Caron. Caractérisation du système de sécrétion Ess/Type VII (SST7) chez Staphylococcus lugdunensis. Journée Normande de Recherche Biomédicale, Nov 2017, Caen, France. ⟨hal-02266192⟩ ...

J Lebeurre, S Dahyot, C Guennoun, I Tournier, P François, et al.. Caractérisation du Système de Sécrétion Ess/Type VII de Staphylococcus lugdunensis. Journée Normande de Recherche Biomédicale, Sep 2016, Rouen, France. ⟨hal-02265853⟩ ...

S. lugdunensis is a recently described coagulase negative Staphylococcus species that has been determined by our group and others to be a virulent human pathogen, capable of causing diseases more akin to Staphylococcus aureus than a typical coagulase negative Staphylococcus species (e.g., native valve endocarditis). This suggests that this species has unique characteristics differentiating it from other coagulase negative Staphylococcus species. The types of infection caused by S. lugdunensis, supported by data generated in our laboratory demonstrating the ability of this organism to form biofilm, suggest that biofilm formation contributes to this species virulence.. We have identified a locus with homology to the S. aureus and Staphylococcus epidermidis ica loci in S. lugdunensis. Interestingly, S. lugdunensis forms biofilm, but its biofilm extracellular matrix is predominantly proteinaceous. Understanding the mechanisms of biofilm formation in S. lugdunensis should enable new, more effective ...

Conventional methods for detecting ornithine decarboxylase activity require an extended period of incubation. The tests generally involve the fermentation of glucose, which lowers the pH of the medium to the optimum hydrogen ion concentration for decarboxylase activity. Decarboxylation results in the formation of amines that will raise the pH. Positive reactions are usually obtained after 18 to 24 hours of incubation, but some strains require up to four days incubation. An overlay of mineral oil acts as a barrier to oxygen and prevents alkalinization of the surface of the medium. Fay and Barry modified the conventional decarboxylase medium by removing the glucose and decreasing the pH to 5.5.(7) A small volume of the broth is heavily inoculated and then overlayed with sterile mineral oil. With the Hardy Diagnostics Rapid Ornithine, results can be obtained after only two to five hours of incubation at 35 to 37ºC.. The test can be used to determine ornithine decarboxylase activity in the family ...

The phosphoenolpyruvate (PEP)-dependent phosphotransferase system (PTS) is a major mechanism used by bacteria for uptake of carbohydrates, particularly hexoses, hexitols, and disaccharides, where the source of energy is from PEP. The PTS consists of two general components, enzyme I (EI) and histidine phosphocarrier protein (HPr), and of membrane-bound sugar specific permeases (enzymes II). Each enzyme II (EII) complex consists of one or two hydrophobic integral membrane domains (domains C and D) and two hydrophilic domains (domains A and B). EII complexes may exist as distinct proteins or as a single multidomain protein. The PTS catalyzes the uptake of carbohydrates and their conversion into their respective phosphoesters during transport. There are four successive phosphoryl transfers in the PTS. Initial autophosphorylation of EI, using PEP as a substrate, is followed by transfer of the phosphoryl group from EI to HPr. EIIA catalyzes the self-phosphoryl transfer from HPr after which the ...

Terpenoids, also known as isoprenoids, are a large class of natural products consisting of isoprene (C5) units. There are two biosynthetic pathways, the mevalonate pathway [MD:M00095] and the non-mevalonate pathway or the MEP/DOXP pathway [MD:M00096], for the terpenoid building blocks: isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). The action of prenyltransferases then generates higher-order building blocks: geranyl diphosphate (GPP), farsenyl diphosphate (FPP), and geranylgeranyl diphosphate (GGPP), which are the precursors of monoterpenoids (C10), sesquiterpenoids (C15), and diterpenoids (C20), respectively. Condensation of these building blocks gives rise to the precursors of sterols (C30) and carotenoids (C40). The MEP/DOXP pathway is absent in higher animals and fungi, but in green plants the MEP/DOXP and mevalonate pathways co-exist in separate cellular compartments. The MEP/DOXP pathway, operating in the plastids, is responsible for the formation of essential oil ...

Some people have nasal bacteria - Staphylococcus lugdunensis, that kills other disease causing bacteria such as Staphylococcus aureus (including strains of MRSA) and Enterococcus. This is because S. lugdunensis produces a molecule (lugdunin) that acts as an antibiotic. It is thought that 10% of people naturally carry S. lugdunensis in their nasal passages. Will this lead to a new class of antibiotics or to probiotics of the future? Could it help in treating sinusitis? Stay tuned... From Science News:. The nose knows how to fight staph. The human nose harbors not only a deadly enemy - Staphylococcus aureus - but also its natural foe. Scientists have now isolated a compound from that foe that might combat MRSA, the methicillin-resistant strain of S. aureus....Investigating the intense interspecies competition in the nose - where microbes fight for space and access to scant sugars and amino acids - might offer a fertile alternative to searching for new drug candidates in soil microbes.. Despite ...

Staphylococcus lugdunensis is an emerging pathogen in skin and soft tissue infections that was previously considered a commensal. The aim of this study was to e

Antibiotic-resistant bacteria are an increasing health threat, making new antibiotics essential. German researchers have recently had a breakthrough: they discovered lugdunin in the human nose a new kind of cyclic peptide that comes from the bacterium Staphylococcus lugdunensis and has strong antimicrobial properties against Stahphylococcus aureus, among others. The researchers have been able to clarify the mode of action by synthesizing variants. As they explain in the journal Angewan...

Staphylococcus lugdunensis paid me a visit. Saw the dermatologist the previous Monday and he said I could get sick pretty quickly if it went beyond skin abscesses, and he gave me some pills... well last Monday morning I came home early from work feeling rotten, slept until about 7pm, and woke up with an awful fever. Wife called Dr. Derm and he said Get that guy to the ER. So there I spent the next four hours downloading IV fluids and medicines, getting a chest X-ray and blood cultures. Sometimes this stuff can get into your heart lining and... well, impede your cycling performance pretty bad... so good thing Dear Wife brought me in ...

(2004) Nilsson et al. FEMS Microbiology Letters. A gene called fbl, encoding a Staphylococcus lugdunensis fibrinogen-binding protein, was identified by phage display. The encoded protein, Fbl, is a member of the Sdr-family, a group of staphylococcal cell surface proteins containing a characterist...

The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex assemblies. As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.

La Via Aquitània èra la principala via romana de la província dAquitània. Sas limitas son, al sud los Pirenèus,[1] a loèst lOcean Atlantic, e al nòrd lo riu Lèger.[2] La Via Aquitània començava a Narbona, e si connectava a la Via Domícia. Narbona èra la primièra colonia romana de Gàllia, de vocacion agricòla.[3] En mai de Narbona, doas vilas importantas, Tolosa e Bordèu, se trapavan lo long de la via, principala rota comerciala que las ligava a lAtlantic[4] A Tolosa, la Via Aquitánia copa de carrièras que menan al nòrd (cap a Lion subretot, quèra en aquel temps linterseccion de las rotas galas). Tolosa mas venguèt la capitala dels Visigòts. La Via Aquitània sacabava a Burdigala, (Bordèu). Bordèu èra una importanta vila comerciala a causa de la proximitat de lOcean Atlantic. Aprèp que Gàllia foguèt devesida en tres províncias: Aquitánia, Belgica, e Lugdunensis, Bordèu venguèt la la capitala dAquitánia. La Via Aquitánia ligava aquelas importantas vilas ...

포도상구균의 Phenol-soluble modulin (PSM) 펩타이드 덕성여자대학교 바이오공학과주황수 교수 포도상구균(Staphylococcus)의 대표 주자라 할 수 있는 황색 포도상구균(Staphylococcus aureus)은 그 악명 높은 항생제 내성뿐만 아니라 독소만 해도 10여개 이상을 포함하는 다양한 독성인자(virulence factor)로도 유명하다.. ...

And to understand that, we also looked at its competitors. They screened 90 bacteria from the human nose, and found that only S. lugdunensis killed MRSA. When Peschels team infected the skin of mice with S. aureus, lugdunin ointment killed the infection both on the surface and in deeper layers of the skin. ...

To secure permission to reprint this article, email Stephen Davidson.. Charles William Raymond (1820-1901) © George McNeillie. Following in the steps of my father and his sister, who married a brother and sister in the Carman family, my Brother Arthur and sister Fannie married a brother and sister, Charles L. and Emily Perkins, who then lived in the old Rectory below the Parish Church. My sister was married on June 20, 1881, and my brother on December 12, 1883. The two young wives were school friends and very intimate before their marriage, and their parents regarded the exchange of daughters as an admirable arrangement. Both young couples began their married life very happily, but the two young wives each died in the prime of life of septicemia following child-birth. Another near relative, our Cousin Julia Carman, died in like manner a few years previously, and thus three bright young lives went out where probably under modern methods of treatment they might have been saved. A leading ...

The natural habitat of Staphylococcus aureus is the moist squamous epithelium in the anterior nares. About 20% of the human population carry S. aureus permanently in their noses and another 60% of individuals are intermittent carriers. The ability of S. aureus to colonize the nasal epithelium is in part due to expression of surface proteins clumping factor B (ClfB) and the iron-regulated surface determinant A (IsdA), which promote adhesion to desquamated epithelial cells present in the anterior part of the nasal vestibule. S. aureus strain Newman defective in IsdA and ClfB exhibited reduced but not completely defective adherence to squamous cells in indicating that other cell surface components might also contribute. Surface proteins IsdA, ClfB, and the serine-aspartic acid repeat proteins SdrC, SdrD and SdrE were investigated to determine their contribution to the adherence of S. aureus to desquamated nasal epithelial cells. This was achieved by expression of ClfB, IsdA, SdrC, SdrD and SdrE on the

Dëshironi të ulni rreziqet që sjell mbipesha në shëndetin tuaj apo thjesht doni të ndiqni një dietë të përshtatshme dhe të shëndetshme që përmirëson mirëqenien tuaj psiko-fizike? Nëse nuk jetoni në Tiranë, ju mund të merrni një regjim ushqimor të personalizuar on-line nga nutricionste Arlinda Garuci. Dieta e personalizuar përpilohet në bazë të të dhënave që ju jepni gjatë plotësimit të modulit dhe pyetësorit, ndaj është tepër e rëndësishme që këto të dhëna të jenë sa më të sakta.. Dieta kushton 40€ dhe mënyrat e pagesës janë: PayPal, Western Union dhe MoneyGram.. Plotëso modulin. ...

A recruiter with our nursing brand RNnetwork talks about her Filipino heritage, racism shes encountered in the U.S., and how organizations can create a more inclusive workplace for Asian Pacific Islander employees.

INTRODUCTION: We sought to identify the incidence of new 90-day cardiac events, 90-day mortality, 90-day unplanned readmissions, and 30-day emergency

Results: Using simple traction (6 leads) and the LLD stylets (92 leads) aided with telescoping sheaths (15 patients), 96 (98%) leads in 52 (96.3%) patients were successfully removed, with all but one leads removed using a subclavian approach; in 1 patient, the right femoral approach was also required. In 2 patients, distal fragments from one ventricular pacing and one defibrillating lead could not be removed. Finally, lead removal was completely (52/54) (96.3%) or partially (2/54) (3.7%) successful in 54 patients for 96 of 98 leads (98%) without major complications ...

UCL Discovery is UCLs open access repository, showcasing and providing access to UCL research outputs from all UCL disciplines.

Benjamin Gauter-Fleckenstein · Carsten W. Israel · Marc Dorenkamp · Jürgen Dunst · Mattias Roser ·. Rainer Schimpf · Volker Steil · Jörg Schäfer · Ulrike Höller · Frederik Wenz. ...

Author: Surekha.Y.Asangi , Mariraj.J , Sathyanarayan.M.S , Nagabhushan , Rashmi :: Coagulase Negative Staphylococci (cons) Are The Indigenous Flora Of The Human Skin And Mucous Membrane. They Are Usually Contaminants, When Isolated From A Clinical Specimen. These Organisms Are Becoming Increasingly Recognized As Agents Of Clinically...

In March 68, Gaius Julius Vindex, the governor of Gallia Lugdunensis, rebelled against Neros tax policies.[61][62] Lucius Verginius Rufus, the governor of Germania Superior, was ordered to put down Vindexs rebellion.[63] In an attempt to gain support from outside his own province, Vindex called upon Servius Sulpicius Galba, the governor of Hispania Tarraconensis, to join the rebellion and further, to declare himself emperor in opposition to Nero.[64] At the Battle of Vesontio in May 68, Verginius forces easily defeated those of Vindex and the latter committed suicide.[63] However, after putting down this one rebel, Verginius legions attempted to proclaim their own commander as Emperor. Verginius refused to act against Nero, but the discontent of the legions of Germany and the continued opposition of Galba in Spain did not bode well for him. While Nero had retained some control of the situation, support for Galba increased despite his being officially declared a public enemy (hostis ...

Bakgrund: Amning är av stor betydelse för det nyfödda barnet och mamma, både ur närings- och trygghetsaspekter. Tidigare studier om sambandet mellan förlossningssätt och amning visar motstridiga resultat; vissa studier indikerar att sectio påverkar amningen negativt medan andra studier inte visar på något samband. Syftet: Att undersöka huruvida det finns demografiska och hälsorelaterade skillnader hos mammor gällande förlossningssätt samt om förlossningssätt påverkar amningsdurationen upp till två månaders ålder. Metod: Studien har en populationsbaserad kohortdesign och omfattar n= 35250 mamma-barn par i Örebro- och Uppsala län, där barnet fötts åren 1993-2001. Statistiska analyser har genomförts med Chi-square test, binär logistisk regressionsanalys och multivariat logistik regressionsanalys. Resultat: Visade att mammor som förlösts med sectio ammade i lägre utsträckning vid två månaders ålder i jämförelse med mammor som förlösts vaginalt. Många ...

TY - JOUR. T1 - Pulmonary embolism in patients with transvenous cardiac implantable electronic device leads. AU - Noheria, Amit. AU - Ponamgi, Shiva P.. AU - DeSimone, Christopher V.. AU - Vaidya, Vaibhav R.. AU - Aakre, Christopher A.. AU - Ebrille, Elisa. AU - Hu, Tiffany. AU - Hodge, David O.. AU - Slusser, Joshua P.. AU - Ammash, Naser M.. AU - Bruce, Charles J. AU - Rabinstein, Alejandro. AU - Friedman, Paul Andrew. AU - Asirvatham, Samuel J. PY - 2016/2/1. Y1 - 2016/2/1. N2 - Background Cardiac implantable electronic devices (CIEDs) are commonly associated with transvenous lead-related thrombi that can cause pulmonary embolism (PE). Methods and results We retrospectively evaluated all patients with transvenous CIED leads implanted at Mayo Clinic Rochester between 1 January 2000, and 25 October 2010. Pulmonary embolism outcomes during follow-up were screened using diagnosis codes and confirmed with imaging study reports. Of 5646 CIED patients (age 67.3 ± 16.3 years, 64% men, mean follow-up ...

There are many challenging infectious disease questions in diagnostic radiology where 18F-FDG PET/CT may be a practical and useful solution.1,2 One of them i...

AbstractIn a non-randomized cohort study, we compared continuous with interrupted sutures for the closure of the lower uterine segment at cesarean section. Eighty-two women, who underwent cesarean section at the Department of Obstetrics at the University Hospital of Vienna between January and May 20

Assistant professor, School of Medicine and Public Health Expert on medical and invasive management of patients with cardiac arrhythmias and cardiac implantable electronic devices ...

Transvenous pacemakers have been used for over 50 years and transvenous defibrillators for over 25 years; efforts to analyze complications affecting patients with cardiac implantable electronic devices (CIEDs) have intensified (1,2). Infection is a devastating complication experienced by patients with CIEDs-impacting morbidity, mortality, quality of life, and heath care costs (3).. In this issue of the Journal, Essebag et al. (4) examine data from the BRUISE CONTROL (BRidge or continUe coumadIn for device SurgEry randomized CONTROLled trial extended follow-up for INFECTION) trial connecting 2 of the more frequent complications of CIED procedures. Study strengths include strict definitions of both clinically significant hematoma (CSH) and significant infections, and the follow-up period of 1 year. The infection rate in this study was 2.4%, greater than described in other recent series (1,5-9). All infections required hospitalization and were treated with parenteral antibiotics and complete system ...

Flywheel Tourniquet System and Method of Application | Cardiac Implantable Electronic Device Pocket Compression Apparatus and Method of Mitigating Localized Bleeding... | APPARATUS FOR DELIVERING FILAMENTARY MATERIAL INTO A PATIENT | Method of Applying Hemostatic or Tissue Healing Agent to Wet Surfaces | CATHETER LUMEN PARTITIONER |

Bellerophon Therapeutics announced on July 27 that top-line results from a clinical trial found its investigational cardiac implantable device did not improve outcomes compared with placebo.

But Im a little different to him, Im called a coagulase negative staph, which means I react differently then him in a special test. ...

But Im a little different to him, Im called a coagulase negative staph, which means I react differently then him in a special test. ...

The current study provides an updated contemporary epidemiology of the microbiology of CIED infections requiring extraction. It is the largest report to date on this topic and used multiple sources for microorganism cultures including lead or lead material, blood, pocket tissue, and pocket swab cultures. There were multiple observations with direct implications for clinical practice and patient management.. This topic is becoming increasingly relevant in clinical practice due to an increase in the number of CIED implants but, most important, due to increase in CIED infections (2,3). In fact, the longevity of patients with cardiac disease has increased and the number of system revisions or upgrades that a patient would require in a lifetime will increase in parallel. The risk of a CIED infection, a time-dependent variable, would likely follow a similar trend and the rates of CIED infections have indeed shown a disproportionate trend to increasing CIED implants (2,3). CIED infections carry not ...

Coagulase negative staphylococci, CoNS infection, Staphylococcus coagulase negative, Non-pathogenic staphylococci. Authoritative facts from DermNet New Zealand.

Nov. 18, 1969 w. GREATBATCH 3,478,746 CARDIAC IMPLANTABLE DEMAND PACEMAKER Filed May 12, 1965 2 Sheets-Sheet 1 Q l-0IVEIEART BEAT F! G. I INVENTOR. WIL SON GREA TBA TCI-I A 7 TORNE). 2 Sheets-Sheet 2 Filed May 12, 1965 A 7 TOR/VEK United States Patent M 3,478,746 CARDIAC IMPLANTABLE DEMAND PACEMAKER Wilson Greatbatch, Clarence, N.Y., assignor to Medtronic, Inc., Minneapolis, Minn., a corporation of Minnesota Filed May 12, 1965, Ser. No. 455,132 Int. Cl. A61n N36 US. Cl. 128-421 4 Claims ABSTRACT OF THE DISCLOSURE A portable, self-contained, demand cardiac Pacemaker including circuitry which senses each natural heartbeat and resets the Pacemaker pulse generator timing in response to it. The Pacemaker stimulates only skipped beats and does not compete with natural beats, The first generated pulse after a natural beat occurs after a preset time interval slightly longer than the natural interval unless another natural beat has intervened. When a natural beat intervenes, the Pacemaker timer is ...

Several members of the staphylococcal phenol-soluble modulin (PSM) peptide family exhibit pronounced capacities to lyse eukaryotic cells, such as neutrophils, monocytes, and erythrocytes. This is commonly assumed to be due to the amphipathic, α-helical structure of PSMs, giving PSMs detergent-like characteristics and allowing for a relatively non-specific destruction of biological membranes. However, the capacities of PSMs to lyse synthetic phospholipid vesicles have not been investigated. Here, we analyzed lysis of synthetic phosphatidylcholine (1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, POPC) vesicles by all Staphylococcus aureus and S. epidermidis PSMs. In addition, we investigated the lytic capacities of culture filtrates obtained from different S. aureus PSM deletion mutants toward POPC vesicles. Our results show that all staphylococcal PSMs have phospholipid vesicle-lysing activity and the capacity of S. aureus culture filtrate to lyse POPC vesicles is exclusively dependent on PSMs.

The genus Staphylococcus consists of an ever-expanding group of gram-positive cocci that have evolved to colonize specific environmental niches, including preferential human tissues and diverse mammalian species. The study of staphylococcal biofilms in vitro has the advantage that in vivo foreign body-associated infections are often colonized by what seems to be single strains or species. The capsular polysaccharide adhesin (PS/A) was isolated from biofilm-forming S. epidermidis and shown to mediate binding of the bacteria to silastic catheter surfaces. More recently identified members of this family of autolysin/adhesins include the homologous Staphylococcus saprophyticus autolysin, Aas, which was shown to bind fibronectin and sheep erythrocytes and to exhibit bacteriolytic properties. The presence of an icaA homolog has also been inferred in S. auricularis, S. capitis, S. intermedius, S. lugdunensis, S. piscifermentans, and S. pasteuri based on DNA cross-hybridization experiments. Some of the

BETHESDA, Md.--(BUSINESS WIRE)--Jan 29, 2013--GE Capital, Healthcare Financial Services announced today that it is serving as administrative agent on an $8.5 million in senior secured credit facility for TYRX, Inc., consisting of a $7 million term loan and a $1.5 million revolving line of credit. The financing will be used to refinance existing debt, working capital and to support commercialization efforts.. TYRX, Inc. is a leader in the commercialization of implantable medical devices designed to help reduce surgical-site infections associated with cardiac implantable electronic devices (CIEDs) including pacemakers and implantable defibrillators.. This financing provided by GE Capital plays an important role in our ability to create and commercialize solutions for surgical-site infections associated with implanted medical devices said Robert White, President and CEO of TYRX. The GE Capital team thoroughly understands our business and structured this loan to match our needs. Customers ...

Dr Jeremy Chow graduated with Bachelor of Medicine and Bachelor of Surgery from the National University of Singapore in 2001. He completed his basic specialist training in Internal Medicine and obtained the Master of Medicine in Internal Medicine from the National University of Singapore in 2006. In the same year, he was admitted as Member to both the Royal College of Physicians of United Kingdom and the Royal College of Physicians of London.. Dr Chow is a certified cardiologist since 2010 upon completion of his advanced specialist training in Cardiology at Changi General Hospital and National Heart Centre of Singapore. He was awarded a scholarship from the Ministry of Health, Singapore under the Health Manpower Development Plan for further specialisation in cardiac implantable electronic devices and electrophysiology in Germany. He completed his fellowship under the mentorship of Dr Johannes Sperzel, a leading cardiac electrophysiologist in Kerckhoff Klinik, Bad Nauheim. Dr Chow sub- ...

Dr Jeremy Chow graduated with Bachelor of Medicine and Bachelor of Surgery from the National University of Singapore in 2001. He completed his basic specialist training in Internal Medicine and obtained the Master of Medicine in Internal Medicine from the National University of Singapore in 2006. In the same year, he was admitted as Member to both the Royal College of Physicians of United Kingdom and the Royal College of Physicians of London.. Dr Chow is a certified cardiologist since 2010 upon completion of his advanced specialist training in Cardiology at Changi General Hospital and National Heart Centre of Singapore. He was awarded a scholarship from the Ministry of Health, Singapore under the Health Manpower Development Plan for further specialisation in cardiac implantable electronic devices and electrophysiology in Germany. He completed his fellowship under the mentorship of Dr Johannes Sperzel, a leading cardiac electrophysiologist in Kerckhoff Klinik, Bad Nauheim. Dr Chow sub- ...

Varicella-zoster virus (VZV) infection causes two clinically distinct forms of disease. Primary infection with VZV results in varicella (chickenpox), characterized by vesicular lesions in different stages of development on the face, trunk, and extrem

Historically, varicella has been a disease predominantly affecting preschool and school-aged children in the United States. The live attenuated varicella vaccine was licensed in this country in 1995 and has been recommended for routine use in immunization of children 12 to 18 months of age. As an in …