Three crude oligosaccharides were respectively prepared by acid hydrolysis of three polysaccharides, which were water-extracted polysaccharide (WEP), sodium hydroxide-extracted polysaccharide (SEP) and acid-extracted polysaccharide (AEP) from the rhizomes of Dioscorea zingiberensis. Among the three oligosaccharides, the crude oligosaccharide prepared by acid hydrolysis of WEP was found to be the most efficient elicitor to enhance the production of palmarumycins C12 and C13 in liquid culture of endophytic fungus Berkleasmium sp. Dzf12. When OW was applied to the medium at 300 mg/L on day 3 of culture, the maximal yields of palmarumycin C12 (87.96 mg/L) and palmarumycin C13 (422.28 mg/L) were achieved on day 15 of culture, which were 9.83 and 3.24-fold in comparison with those (8.95 and 130.43 mg/L) of control, respectively. The results indicate that addition of the oligosaccharides from the host plant D. zingiberensis should be an effective strategy for enhancing production of palmarumycins C12 and C13
0078] In a preferred embodiment of the method of the present invention the ring system formed by R1 and R2 is [0079] (i) cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, cyclononyl, cyclodecyl, spiro[3,3]heptyl, spiro[3,4]octyl, spiro[4,3]octyl, spiro[3,5]nonyl, spiro[5,3]nonyl, spiro[3,6]decyl, spiro[6,3]decyl, spiro[4,5]decyl, spiro[5,4]decyl, bicyclo[4.1.0]heptyl, bicyclo[3.2.0]heptyl, bicyclo[2.2.1]heptyl, bicyclo[2.2.2]octyl, bicyclo[5.1.0]octyl, bicyclo[4.2.0]octyl, bicyclo[5.3.0]decyl, octahydro-pentalenyl, octahydro-indenyl, decahydro-azulenyl, adamantly, or decahydro-naphthalenyl; optionally substituted 1 to 14 times, i.e. 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, or 14 times, depending on the number of available valences with a substituent which is in each instance independently selected from the group consisting of halogen, in particular F, Cl, Br or I; --NO2; --CN; --OR6; --NR6R7; --COOR6; --CONR6R7; --NR8COR9; --NR8COR9; --NR8CONR6R7; --NR9SO2A; --COR6; ...
An easy access to amine appended spiro[indoline-3,4-pyridine] ON-OFF chemosensor by one pot four-component reaction using commercially available and environmentally benign catalytic amount of molecular I2 (10 mol %) in aqueous ethanol at ambient temperature is described. The generated system can be utilized
3-METHYL-4-(2-PROPENYL)-SPIRO[FURAN-2(5H),3-[3H]INDOL]-2(1H)-ONE 882041-52-3 NMR spectrum, 3-METHYL-4-(2-PROPENYL)-SPIRO[FURAN-2(5H),3-[3H]INDOL]-2(1H)-ONE H-NMR spectral analysis, 3-METHYL-4-(2-PROPENYL)-SPIRO[FURAN-2(5H),3-[3H]INDOL]-2(1H)-ONE C-NMR spectral analysis ect.
The flat surface spheroid migration assay suggested that siramesine killed migrating glioma cells. PI uptake in migrating tumor cells already detached from the spheroids was seen and there was a significant decrease in spheroid migration distance. Part of this decrease may also be explained by tumor cell death in the spheroid itself. In the organotypic 3D migration assay distance of invasion was not affected by siramesine in any of the cultures. However, some of the migrating tumor cells appeared to have lost their membrane protrusions, appearing as small rounded cells suggesting a stop in migration. These cells were primarily seen at concentrations of 100 μM siramesine being however toxic to the brain tissue and thus irrelevant in a clinical setting. It could be speculated if the lack of effect of siramesine on implanted invasive spheroids was due to a phenotypic migration-related shift making the tumor cells siramesine resistant. A phenotypic shift has previously been described as part of the ...
Title:A Facile Synthesis and Anticancer Activity Evaluation of Spiro Analogues of Benzothiazolylchromeno/pyrano Derivatives. VOLUME: 11 ISSUE: 5. Author(s):Anand Kumar Arya, Kulbhushan Rana and Mahendra Kumar. Affiliation:Department of Chemistry, University of Rajasthan, Jaipur-302 055, India.. Keywords:Multicomponent reactions, Spiroheterocycles, Cytotoxic activity, SRB assay, 2-aminobenzothiazole, Water.. Abstract:The spiro analogues of benzothiazolylchromenopyranopyridine, benzothiazolyl- chromenoquinoline, benzothiazolylpyranoquinoline, benzothiazolylchromenopyridopyrimidine and benzothiazolylpyranopyridopyrimidine have been synthesized by an efficient domino reaction using sulfamic acid as catalyst in aqueous medium and screened for their cytotoxic activity against tumor cell lines, namely human cancer cell lines of colon (sw620), breast (MCF-7), cervix (HeLa) and heptatoma (HepG2) using a sulforhodamine B (SRB) assay. The synthesized compounds have shown promising cytotoxic activity ...
Description: The BTL-08 Spiro & BTL-08 Spiro Pro are modern compact spirometers for performing non-invasive pulmonary function tests and managing patient records comfortably and quickly. The minimum operational costs of the units are ensured by reusable sensor that can be easily disinfected. The measurements are carried out with maximum accuracy in the wide range of air flow and minimum air flow resistance. The units feature in-built sensors for automatic BTPS correction of examination results. The results can be previewed on the large color display prior to printing. ...
Earl Rausch and Rachel Spiro recently marked 25 years employed by Risk Management Insurance, one of the largest commercial insurance firms in Southwest Florida. Rausch is president of the Fort Myers-based firm, and Spiro is responsible for working...
Whats 3-methyl-4-methylidene-8,8-bis(3-phenylpropyl)-1-oxa-3-aza-8-azoniaspiro[4.5]decan-2-one,iodide 134070-01-2, 3-methyl-4-methylidene-8,8-bis(3-phenylpropyl)-1-oxa-3-aza-8-azoniaspiro[4.5]decan-2-one,iodide uses search, 3-methyl-4-methylidene-8,8-bis(3-phenylpropyl)-1-oxa-3-aza-8-azoniaspiro[4.5]decan-2-one,iodide price, CAS NO., byname ect.
Recent advances in synthetic and medicinal chemistry of saturated spirocyclic nitrogen-containing heterocycles with gem-difluorocycloalkane moieties are surveyed, including results published in the last decade. In particular, gem-difluoro-substituted derivatives of azaspiro[2.n]alkanes, azaspiro[3.n]alkanes, azaspiro[4.5]decane, and other spirocyclic scaffolds are discussed.. ...
Public health care has reached a level where tissue or organ reconstruction by means of biodegradable short-term implants via e.g. tissue engineering will be practicable in the near future. The vital issue now is to be able to reproducibly fabricate and design new materials with the appropriate properties and three-dimensional shape, and to facilitate their sterilization. In this thesis, macromolecular design and polymer architecture techniques are used to synthesize well-defined polymers with narrow molecular weight distributions (MWD), and to control the reactions upon sterilization, and the degradation rate and profile.. A model system for the ring-opening polymerization of L-lactide (LLA) initiated by a spirocyclic tin initiator was developed to synthesize star-shaped polymers. It was shown that an increase in temperature and a decrease in the dielectrical constant of the solvents increased the reaction rate. The versatility of the spirocyclic tin initiator system was subsequently ...
2-Tert-butyl-1-(3-chloro-1H-indole-6-carbonyl)spiro[4,6-dihydropyrazolo[3,4-c]pyridine-5,4-piperidine]-7-one | C23H26ClN5O2 | CID 56967950 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
Ryan, R.P., Fouhy, Y., Lucey, J.F., Crossman, L.C. Spiro, S., He, Y-W., Zhang, L-H., Heeb, S., Cámara, M., Williams, P. and Dow, J.M. (2006) Cell-cell signaling in Xanthomonas campestris involves an HD-GYP domain protein that functions in cyclic di-GMP turnover. Proceedings of the National Academy of Sciences USA 103: 6712-6717.[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16611728&query_hl=1&itool=pubmed_docsum ...
Facing Death: Where Culture, Religion, and Medicine Meet by Howard M Spiro (Editor) starting at $6.00. Facing Death: Where Culture, Religion, and Medicine Meet has 2 available editions to buy at Alibris
Can you name the Psychology 110 Terms? Test your knowledge on this science quiz to see how you do and compare your score to others. Quiz by spiro
Simon Spiro shares his experience of IITM and provides an update on his career. Simon read for a VetMB in veterinary medicine at Pembroke College, Cambridge between 2004 and 2010, during which time he also undertook an intercalated MA in Pathology in 2006-7. Prior to starting his DPhil, which was supervised by Nicole Zitzmann in…
Spiro Theodore Agnew (9 de novembro de 1918 - 17 de setembro de 1996) foi um político estadunidense, vice-presidente do seu país entre 1969 e 1973, de origem familiar grega. Teve uma notável subida na carreira política: em apenas seis anos passou de executivo municipal a vice-presidente. Renunciou ao cargo de vice-presidente em 1973 por ter sido acusado de evasão fiscal.[1]. Foi Governador de Maryland (1967-1969) e running mate de Richard Nixon nas eleições presidenciais de 1968.. ...
Get answers to frequently asked dentistry questions here or contact Spiro Saati, DMD and his Peabody, MA team to find out more today.
Infections are one of the most important causes of death, disability and inappropriate conditions for millions of people around the world. Therefore, the development in prognosis, prevention and treatment of infectious diseases made a considerable progress in designing and synthesis of new antimicrobial drugs. Nowadays, due to the increase in microbial resistance, discovery of new compounds with broad spectrum effects is granted. 4H-pyran derivatives and spiro compounds are the most important fragments in some effective drugs with antimicrobial activity. Therefore, in this study, 6 compounds with spiro-4H-pyran core were synthesized and evaluated for their antimicrobial activity against four different bacterial species using microbroth dilution and disk diffusion methods. Minimum inhibitory concentration (MIC) has been measured for each compound and also for the standard antibiotic, gentamicin, and they were all compared together. According to our result, one of the spiropyran derivative (5d) containing
Doherty, P J.; Tsao, J; Schimmer, B P.; Mumby, M C.; and Beavo, J A., "Alteration of the regulatory subunit of type 1 camp-dependent protein kinase in mutant y1 adrenal cells resistant to 8-bromoadenosine 3:5-monophosphate." (1982). Subject Strain Bibliography 1982. 2372 ...
The clip Ordering dinner from Brazil (1985) with Katherine Helmond, Jonathan Pryce. Powered by: Anyclip. any moment from any film. Hello, Shirley. Thank you, Spiro. Salt? Not yet. Sam, happy Christmas. Oh! So sorry were late. Thanks. Now, Alma... what are you going to have? I cant make up my mind whether to have the number one or the number two. What do you recommend, Spiro? Between you and me, madame... today the number two. Thank you, Spiro. Shirley. Shirley, what are you going to have? Between you and me, mademoiselle, today the number one. Madame Lowry? Oh, to hell with the diet. Im going to have a number eight, please. A most perceptive choice if I dare say so, madame. Oh, Ida! Monsieur. Steak, please. Rare. Mother- Monsieur, quel numero? I dont know which number. Mother, please - That one. There. Thats fine. Thanks. Mother, will you please listen to me. Alma! You wicked girl. Youve started your treatment. Say the number, please. You noticed. You have to say the number! Will you please go
In the present work we describe the structure and the spectroscopic characterization of a spirocyclic derivative of a rhodamine B ligand whose properties allow discrimination of light-up effects induced by metal ion chelation and variation of pH. Distinction of the two effects is important for the use of thi Chemistry and applications of metal complexes
2,7-Diazaspiro[4.5]decan-1-one hydrochloride/ACM1187173438 can be provided in Alfa Chemistry. We are dedicated to provide our customers the best products and services.
Strain 12A35 was isolated from a deep-sea sediment collected from the South China Sea and showed promising antibacterial activities. It was identified as Streptomyces sp. by the 16S rDNA sequence analysis. Bioassay-guided fractionation using HP20 adsorption, flash chromatography over silica gel and octadecylsilyl (ODS) and semi-preparative HPLC, led to the isolation and purification of five metabolites from the fermentation culture of 12A35. Two new spirotetronate antibiotics, lobophorins H (1) and I (2), along with three known analogues, O-β-kijanosyl-(1→17)-kijanolide (3), lobophorins B (4) and F (5) were characterized by 1D, 2D-NMR and MS data. These compounds exhibited significant inhibitory activities against Bacillus subtilis. Compounds 1 and 5 exhibited moderate activities against Staphylococcus aureus. In particular, the new compound lobophorin H (1) showed similar antibacterial activities against B. subtilis CMCC63501 to ampicillin.
Selected Research Publications. Jackson, J. J.; Stivala, C. E.; Iorga, B. I.; Molgo, J.; Zakarian, A., Stability of Cyclic Imine Toxins: Interconversion of Pinnatoxin Amino Ketone and Pinnatoxin A in Aqueous Media, JOC, 2012, 77, 10435-10440. Stivala, C. E.; Gu, Z.; Smith, L. L.; Zakarian, A., Studies toward the synthesis of spirolide C: Exploration into the formation of the 23-membered all-carbon macrocyclic framework, Org Lett, 2012, 14, 3, p. 804-807. Herrmann, A. T.; Smith, L. L.; Zakarian, A., A simple method for asymmetric trifluoromethylation of N-acyl oxazolidinones vis Ru-catalyzed radical addition to zirconium enolates, JACS, 2012, 134, 6976-6979. Gu, Z.; Zakarian, A., Studies toward the synthesis of maoecrystal-V, Org Lett, 2011, 13, 5, p. 1080-1082. Herrmann, A. T.; Martinez, S. R.; Zakarian, A., A concise asymmetric total synthesis of (+)-brevisamide, Org Lett, 2011, 13, 14, P. 3636-3639. Araoz, R.; Molgoi, J.; Benoit, E.; Iorga, B. I.; Servent, D.; Fruchart-Gaillard, C.; Gu, Z.; ...
Boc Sciences offers cas 933-41-5 1-Thia-4-azaspiro[4.5]decane hydrochloride in bulk,please inquire us to get a quote for 933-41-5 1-Thia-4-azaspiro[4.5]decane hydrochloride.
Product Number: C6085 CAS number: 1841-19-6 unlabeled Synonyms: [2H7]-1,3,8-Triazaspiro[4.5]decan-4-one, 8-[4,4-bis(4-fluorophenyl)butyl]-1-phenyl-. ...
The gem-dialkyl effect has been investigated in the reactions of cyclotriphosphazene, N3P3Cl6 1, with various 2,2-derivatives of 1,3-propandiol, CXY(CH2OH)(2), in either THF or DCM to form spiro (6-membered) and ansa (8-membered ring) derivatives. The reactions were made with a number of symmetrically-substituted (X = Y, methyl, ethyl, n-butyl and a malonate ester) and unsymmetrically-substituted (X not equal Y, methyl/H, phenyl/H, methyl/n-propyl, ethyl/n-butyl and Br/NO2) 1,3-propandiols. The products were analysed by H-1 and P-31 NMR spectroscopy and some of the spiro and ansa derivatives were also characterized by X-ray crystallography. Reactions of 1 with unsymmetrically-substituted 1,3-propandiols results in the formation of two structural isomers of ansa-substituted compounds, both isomers (endo and exo) have been structurally-characterized by X-ray crystallography for the ethyl/n-butyl derivative. It is found that the regioselectivity of the reaction is changed when the base is changed. ...
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice ...
The intramolecular nucleophilic addition of N-methyl-N-(2,4,6-trinitrophenyl)glycine anion in methanol-dimethyl sulfoxide mixtures produces spiro[(3-methyl-5-oxazolidinone)-2,1-(2,4,6-trinitrobenzenide)]. The spiro adduct has been identified by means of 1H and 13C NMR spectroscopy. This is the first case when the formation of a Meisenheimer adduct with carboxylate ion is observed. Logarithm of the equilibrium constant of adduct formation increases linearly with the mole fraction of dimethyl sulfoxide in its mixture with methanol.. ...
TIB Bank had recently made the migration from the Florida Keys to Collier County. As a new player in a marketplace flooded with long-standing financial institutions, it was imperative that they establish themselves as a viable banking institution both on the residential side and on the commercial side ...
25 zzzRegistered Nurse - Per Diem- Kindred Hospital Greensboro SAU Greensboro, NC, USA You want to work in a healthcare setting where you are valued and appreciated - where you receive respect from your superiors and co-workers as well as the patients you treat. You want to be ...... Apply Now>> ...
17-Alpha-Oxo-Nolone, anyone ever hear of this before. 17 Alpha Safety and Information By: Dr. Jim Kimbrell Ph.D. Biochemistry & Molecular
Not only is there evidence that Spiro may be interfering with the primary goal of HRT, but Spiro may be directly responsible for patient harm by crippling the cognitive ability of patients and compromising their ability to withstand stress
Not only is there evidence that Spiro may be interfering with the primary goal of HRT, but Spiro may be directly responsible for patient harm by crippling the cognitive ability of patients and compromising their ability to withstand stress
Hello Dr. Redmond, I am currently taking Ocella (Yasmen 28) three months on,4 days off since January 2007. Since April 2007, I also take Spiro 100 mg per day (I did take 200 mg at first but dropped just a month ago to 100 because my heart began to hurt 20 or so minutes after taking) and as of September this year, I am also taking 2.5 mg of Finasteride. The beginning results of just taking the pill for three months straight did not improve my hair loss. When I did include the Spiro in
If you think this add-on violates Mozillas add-on policies or has security or privacy issues, please report these issues to Mozilla using this form.. Please dont use this form to report bugs or request add-on features; this report will be sent to Mozilla and not to the add-on developer. ...
I sometimes take for granted my profession. After taking my board recertification this past week, I now have many new facts and minutia in my mind that I had forgotten and now remembered. And will soon forget again. But the …. Continue reading. ...
|p|Avoiding exposure to insects includes using caution while being one with nature. This combination encourages your bodys healthy conditions. An asset to hair and clothing checks after a jaunt in the woods.|/p|
I was pleased and honored to receive this note from one of the Woodburn Ambulance Service paramedics, Elliott Williams, who is newly contributing 911-response video cases to ReelDx: "David, I really so think youve created something powerful here. The response …. Continue reading. ...
This work has been made available to the staff and students of the University of Sydney for the purposes of research and study only. It constitutes material that is held by the University for the purposes of reporting for HERDC and the ERA. This work may not be downloaded, copied and distributed to any third party ...
Synthesis of 17b-hydroxy-androst-4-eno[3,2-c]pyrazole 3, 17b-hydroxy-androst-4-eno[3,2-c]-1 H-5 -methylthio-pyrazole 4, 17b-hydroxy-androst-4-eno[2,3-d]isoxazole 5, 17b-hydroxy-androst-4-eno[2,3-d] -1 H-3 -methylthio isoxazole 6, 17b-hydroxy-androst-4-eno[3,2-d]-2 -amino-6 -ethoxypyrimidine 7, 17b,2 -dihydroxy-androst-4-eno[3,2-d]- 6 -ethoxypyrimidine 8, and 17b-hydroxy-androst-4-eno[3,2-d]-2 -thiolo-6 -ethoxypyrimidine 9, 17b-hydroxy-4-androsteno[3,2-d]-2 -amino-6 -ethoxypyrimidine 10, 17b,2 -dihydroxy-4-androsteno[3,2-d]-6 ethoxypyrimidine 11, 17b-hydroxy-4-androsteno[3,2-d]-2 -thiolo-6 -ethoxypyrimidine 12, from 2-ethoxymethylene-4-androsten-3-one 1 and 2-bis (methylthio) methylene-4-androsten-3-one 2 are reported ...
Chen, K. C., Yin, W. H., Wu, C. C., Chan, S. H., Wu, Y. W., Wang, K. Y., Chang, K. C., Hwang, J. J., Voon, W. C., Hsieh, I. C., Chong, J. T., Lin, W. S., Hsu, C. N., Ueng, K. C., Hsia, C. P., Liu, J. C., Yeh, J. S., Mar, G. Y., Shih, J. Y., Kuo, J. Y. 及其他8, Tsao, H. M., Tseng, W. K., Yang, C. H., Chang, C. C., Chiang, C. E., Lei, M. H., Lin, J. F. & Shyu, K. G., 五月 1 2018, 於 : Acta Cardiologica Sinica. 34, 3, p. 211-223 13 p.. 研究成果: 雜誌貢獻 › 文章 ...
METHODS AND COMPOSITIONS FOR TREATING DIABETES, METABOLIC SYNDROME AND OTHER CONDITIONS | AZA Spiro Alkane Derivatives as Inhibitors of Metalloproteases | Dosing Regimens for Fast Onset of Antidepressant Effect | COMPOSITIONS FOR THE MOBILIZATION, HOMING, EXPANSION AND DIFFERENTIATION OF STEM CELLS AND METHODS OF USING THE... | Solid Dispersion Comprising .mu.-Opioid Antagonists |
General Characteristics SnAP (Sn(tin) Amine Protocol) reagents provide an easy access to a variety of saturated heterocycles and amines containing a spiro skeleton. The simple two-step procedure .... ...
General Characteristics SnAP (Sn(tin) Amine Protocol) reagents provide an easy access to a variety of saturated heterocycles and amines containing a spiro skeleton. The simple two-step procedure .... ...
P,N-sp3-bidentate chiral ligands bearing spiro[indane-1,2-pyrrolidine] backbone were prepared in gram scale for the first time. Pd complexes of these ...
I dont believe there are any APIs that require index buffers, and OpenGL ES * does not. If you take a naive array of vertices then triangle strips are only faster generally speaking if the resulting index buffer is 75% or below compared to the original size. You should instead sort the vertices by best cache usage, which in my experience has yet to produce slower results than not. From there, if you then generate a triangle strip, my experiments show it only fruitful to keep the strip if the resulting index buffer is 25% or below (basically never). L. Spiro Actually both draw methods in GLES 2 need indices - glDrawArrays uses the indices from the bound array and glDrawElements gets the indices as an argument. See https://www.khronos.org/opengles/sdk/docs/man/xhtml/glDrawArrays.xml for example. It says the index type needs to be unsigned byte or unsigned short - it doesnt look like the indices parameter is optional. And actually the documentation for draw elements that you linked states the ...
Spyropoulos AC, Ageno W, Albers GW, Elliott CG, Halperin JL, Hiatt WR, Maynard GA, Steg PG, Weitz JI, Suh E, Spiro TE, Barnathan ES, Raskob GE. Rivaroxaban for Thromboprophylaxis after Hospitalization for Medical Illness. N Engl J Med. 2018 Sep 20; 379(12):1118-1127 ...
D. J. Richardson, J.-M. Wehrfritz, A. Keech, L. C. Crossman, M. D. Roldan, H. J. Sears, C. S. Butler, A. Reilly, J. W. B. Moir, B. C. Berks, S. J. Ferguson, A. J. Thomson, S. Spiro ...