Ischemic preconditioning has been reported to protect against spinal cord ischemia-reperfusion (I-R) injury, but the underlying mechanisms are not fully understood. To investigate this, Japanese white rabbits underwent I-R (30 min aortic occlusion followed by reperfusion), ischemic preconditioning (three cycles of 5 min aortic occlusion plus 5 min reperfusion) followed by I-R, or sham surgery. At 4 and 24 h following reperfusion, neurological function was assessed using Tarlov scores, blood spinal cord barrier permeability was measured by Evans Blue extravasation, spinal cord edema was evaluated using the wet-dry method, and spinal cord expression of zonula occluden-1 (ZO-1), matrix metalloproteinase-9 (MMP-9), and tumor necrosis factor-α (TNF-α) were measured by Western blot and a real-time polymerase chain reaction. ZO-1 was also assessed using immunofluorescence. Spinal cord I-R injury reduced neurologic scores, and ischemic preconditioning treatment ameliorated this effect. Ischemic
The spinal cord is extremely vulnerable to ischemia-reperfusion (I/R) injury, and the mitochondrion is the most crucial interventional target. Rapamycin can promote autophagy and exert neuroprotective effects in several diseases of the central nervous system. However, the impact of rapamycin via modulating mitophagy and apoptosis after spinal cord ischemia-reperfusion injury remains unclear. This study was undertaken to investigate the potential role of rapamycin in modulating mitophagy and mitochondria-dependent apoptosis using the spinal cord ischemia-reperfusion injury (SCIRI) mouse model. We found that rapamycin significantly (p p + cells in the spinal cord ischemic tissue and improved the locomotor function in these mice. Our results therefore demonstrate that rapamycin can improve the locomotor function by promoting mitophagy and attenuating SCIRI -induced apoptosis, indicating its potential therapeutic application in a spinal cord injury.
Mn porphyrin-based SOD mimic, MnTnHex-2-PyP(5+), and non-SOD mimic, MnTBAP(3-), suppressed rat spinal cord ischemia/reperfusion injury via NF-?B pathways ...
Spinal Cord Ischemia: Reduced blood flow to the spinal cord which is supplied by the anterior spinal artery and the paired posterior spinal arteries. This condition may be associated with ARTERIOSCLEROSIS, trauma, emboli, diseases of the aorta, and other disorders. Prolonged ischemia may lead to INFARCTION of spinal cord tissue.
TY - JOUR. T1 - GDNF and RET induction in motor neurons after spinal cord ischemia.. AU - Abe, Kouji. PY - 2001. Y1 - 2001. M3 - Article. VL - 1221. SP - 161. EP - 168. JO - Excerpta Medica Int. Cong. Series (Abe K ed., Molecular Mechanism and Therapeutics of ALS). JF - Excerpta Medica Int. Cong. Series (Abe K ed., Molecular Mechanism and Therapeutics of ALS). ER - ...
In this brief review, the authors elaborate on status quo of the use of endovascular stent grafts in the management of patients with connective tissue disorders. Because the radial force and circumferential stress on the native aorta remains a signficant issue that leads to stent graft failure, open surgical repair remains the gold standard in most ...
It should be noted that the distribution of vascular syndromes and the distribution of etiologies in this study differ from those in several other studies because of the inclusion/exclusion criteria. For example, by excluding cases associated with surgery (eg, aortic surgery) or trauma, there are fewer cases associated with hypotension and a larger proportion with causes that were not clearly identified. Nevertheless, Masson and colleagues also reported that a definite cause of spinal cord infarction was identified in less than half of patients (Masson et al 2004).. The authors also provided a further analysis of potential etiologic factors. This analysis must be considered exploratory for a number of reasons: (1) data were obtained retrospectively and are susceptible to various forms of bias (recall, ascertainment, etc.); (2) sample sizes within each group were quite small; (3) comparisons were not specified a priori and all comparisons made were not elaborated; (4) given the nature of the ...
On the one month CT scan controls we only found one case of type 1 endoleak in the patient from group 2 that underwent TEVAR with chimney graft to the superior mesenteric artery and that is currently under surveillance.. Discussion. Spinal cord ischemia is a devastating complication of proximal aortic surgery. It is associated with higher operative mortality and has serious long-term repercussions on quality of life and socio-economic status.. Retrospective studies have shown that the major predictor of spinal cord dysfunction is the aortic extension involved in open surgery or endovascular treatment.10. SCI after OR of thoracoabdominal aneurysms has been investigated and its prevalence ranges from 3.8%11 to 13.2%12 in centers with extensive experience. Nevertheless, it can reach higher rates if we evaluate the results of centers with less experience, in the so called "real world".10,13. In general, the risk is substantially higher in more extensive aneurysms (type 1 and 2 TAAA).. If we consider ...
A method for treating ischemia by administering deltorphins to a mammal. Deltorphin I SEQ ID NO:1, delntorphin II SEQ ID NO:2 or combinations of deltorphins I SEQ ID NO:1 and II SEQ ID NO:2 may be administered. A deltorphin concentration of about 0.5-20 mg/kg body weight, or alternatively a lower concentration of about 1-1000 μg/kg body weight of the mammal in a physiologically acceptable formulation is administered up to four hours after an ischemic episode. Deltorphins may also be administered prior to or concurrently with onset of ischemia. Cerebral or spinal cord ischemia or ischemic heart disease may be treated using the method of the invention.
LTI will join other members of the Lehigh Valley Chapter of ASM International at the 2015 Eastern PA Materials Exposition. The event will be held on Thursday, November 12th, 2015 at the Holiday Inn and Conference Center in Breinigsville, PA.
TY - JOUR. T1 - The neuroprotective effect of magnesium sulfate when given prior to spinal cord ischemia in rabbits. AU - Langen, K. E.. AU - Jellish, W. S.. AU - Zhang, X.. AU - Spector, M.. AU - White, F. A.. PY - 2006/1/1. Y1 - 2006/1/1. N2 - Abstracts published in the Journal of Neurosurgical Anesthesiology have been reviewed by the organizations or JNA Affiliate Societies at whose meetings the abstracts have been accepted for presentation. These abstracts have not undergone review by the Editorial Board of the Journal of Neurosurgical Anesthesiology.34th Annual Meeting of the Society of Neurosurgical Anesthesia and Critical Care, Chicago, Illinois, October 13th, 2006.. AB - Abstracts published in the Journal of Neurosurgical Anesthesiology have been reviewed by the organizations or JNA Affiliate Societies at whose meetings the abstracts have been accepted for presentation. These abstracts have not undergone review by the Editorial Board of the Journal of Neurosurgical Anesthesiology.34th ...
Male Sprague-Dawley rats (330-370 g) were anesthetized with isoflurane (5%) in an anesthesia induction box. Upon loss of responsiveness and spontaneous movement, the rat was removed from the induction box and anesthetized continuously with isoflurane (2-2.5%) in an air-oxygen mixture (1:1) during spontaneous respiration. With the rat in the supine position, the dorsal thoracolumbar spinal region was surgically prepared with 70% alcohol. A 2- to 3-cm midline skin incision was made at the level of the upper lumbar area (L1-L3), and vertebral muscles were bluntly dissected from the vertebrae (L1-L3). The spinal process at L2 was removed, and the vertebra at L3 was retracted to expose the intervertebral spaces (L1/2 and L2/3). Both intervertebral ligaments were carefully cut, and one epidural silver electrode was inserted into the epidural space 2 cm cephalad from L1/2, and another was inserted 2 cm caudally from L2/3. The epidural silver electrodes (0.1 mm in diameter; Unique Medical, Fukuoka, ...
Spinal surgery is a relatively common medical procedure with approximately 1.2 million operations occurring annually in the U.S.1 Imaging plays a critical ro...
A young man was hospitalised with sudden onset paresis of the lower extremities, and spinal cord ischaemia was detected. Fibrocartilaginous embolism is most likely an underdiagnosed cause of spinal ...
All self-etching adhesives applied after phosphoric acid exhibited a more retentive etching pattern. Design of software and hardware complex of automated systems for the management of the State Sanitary and Epidemiological Surveillance Group 1 received buy viagra online antibiotics after umbilical-cord clamping (July 2002 to November 2004). However, the sweetness of human milk lysozyme, which is vital for combating microbial infections of the gastrointestinal tract of breast-fed infants, has not been characterized. Causative role of coronary microvessels for the development and progression of chronic myocardial lesions in spontaneously hypertensive rats (SHR).. Preparation of uniform rich cholesterol unilamellar nanovesicles using CO2-expanded solvents. A follow-up study was conducted in forty-one men (fifty-five hands) treated surgically for carpal tunnel syndrome. It is also pointed out that lesser degrees of spinal cord ischemia can produce dysfunction in descending systems which may not be ...
TY - JOUR. T1 - Effect of aminophylline and isoproterenol on spinal cord blood flow after impact injury. AU - Dow-Edwards, D.. AU - DeCrescito, V.. AU - Tomasula, J. J.. AU - Flamm, Eugene S.. PY - 1980. Y1 - 1980. N2 - A study of the effects of spinal cord injury upon spinal cord blood flow was carried out in cats. A 400 g-cm impact produced an overall reduction in spinal cord blood flow of 24% in the white matter and 30% in the gray matter, as determined by 14C-antipyrine autoradiography. At the level of the injury, white-matter flow was 8.1 ml/100 g/min, g/min, a reduction of 49%, and in the gray matter, 12.5 ml/100 g/min, a reduction of 76%. Treatment with aminophylline and isoproterenol improved the overall blood flow in the spinal cord. At the level of the injury, white-matter flow after this treatment was no longer significantly different from control values. The gray-matter flow remained decreased to 26.2 ml/100 g/min, a reduction of only 47%. It is proposed that aminophylline and ...
Aortic cross clamping is associated with spinal cord ischemia. This study used a rat spinal cord ischemia model to investigate the effect of distal aortic pressure on spinal cord perfusion. Male Sprague-Dawley rats (n=12) were divided into thre
Ischemic tolerance is an endogenous neuroprotective phenomenon induced by sublethal ischemia. Ischemic preconditioning (IPC), the first discovered form of ischemic tolerance, is widely seen in many species and in various organs including the brain and the spinal cord. Ischemic tolerance of the spinal cord is less familiar among neurosurgeons, although it has been reported from the viewpoint of preventing ischemic spinal cord injury during aortic surgery. It is important for neurosurgeons to have opportunities to see patients with spinal cord ischemia, and to understand ischemic tolerance of the spinal cord as well as the brain. IPC has a strong neuroprotective effect in animal models of ischemia; however, clinical application of IPC for ischemic brain and spinal diseases is difficult because they cannot be predicted. In addition, one drawback of preconditioning stimuli is that they are also capable of producing injury with only minor changes to their intensity or duration. Numerous methods to ...
Background and Goal of Study: Neurologic deficit is a devastating complication of thoracoabdominal aortic aneurysm repair (TAAAR) and is associated with a significant increase in both, morbidity and mortality. The purpose of this study was to identify predictors of neurologic deficit after TAAAR. Materials and Methods: The subjects for this study comprised 449 consecutive patients
Spinal Cord Function After Injury. spinal cord structure in relation to vertebrae types of lesions fibre tracts in spinal cord sensory loss motor loss reflexes and spinal shock neuropathic pain. Orientation of spinal cord and spinal roots with respect to vertebrae. Posterior. Slideshow 6341268 by oren-livingston
Question - Tingling and numbness in hands and weak legs. Had bones scraped to relieve pressure on spinal cord.. Ask a Doctor about Spinal cord, Ask an Orthopaedic Surgeon
From the Department of Neurosurgery, Surgical Division, University of Wisconsin Medical School, Madison, Wisconsin. Formerly Fellow, Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Md.. ...
Summary Acute Market Reports, Spinal Cord Injury - Pipeline Review, H1 2016 , provides an overview of the Spinal Cord Injury pipeline landscape. The report
​Learn about common symptoms of Tarlov cysts, as well as surgical and nonsurgical treatment options in this neurosurgeon-edited guide.
Study Flashcards On SPINAL CORD - 41 at Cram.com. Quickly memorize the terms, phrases and much more. Cram.com makes it easy to get the grade you want!
Introduction: The rate of spinal cord infarction associated with repair of an aortic aneurysm or dissection is uncertain.. Methods: We identified all adult patients discharged from nonfederal acute care hospitals in California, New York, and Florida who underwent surgical or endovascular repair of a thoracic or abdominal aortic aneurysm or dissection between 2005 and 2013. Our outcome was a spinal cord infarction (ICD9-CM codes: 336.1 or 344.1-5) occurring during the index hospitalization for aortic repair. Patients with a spinal cord infarction prior to the hospitalization for aortic repair were excluded. Descriptive statistics with exact confidence intervals (CIs) were used to report crude rates of spinal cord infarction in patients with repair of ruptured aortic aneurysm or dissection and in patients with repair of unruptured aneurysm. In a secondary analysis, we evaluated the rate of spinal cord infarction in these groups by treatment approach - surgical versus endovascular.. Results: We ...
• Han JJ, Massagli TL and Jaffe KM (2004). Fibrocartilaginous embolism--an uncommon cause of spinal cord infarction: a case report and review of the literature. Arch Phys Med Rehabil. 85: 153-7. Childrens Hospital and Regional Medical Center and Department of Rehabilitation Medicine, University of Washington, Seattle, USA. [email protected] Fibrocartilaginous embolism is a rare cause of spinal cord infarction. It is postulated that an acute vertical disk herniation of the nucleus
TY - JOUR. T1 - Induction of phosphatidylinositol 3-kinase and serine-threonine kinase-like immunoreactivity in rabbit spinal cord after transient ischemia. AU - Sakurai, Masahiro. AU - Hayashi, Takeshi. AU - Abe, Koji. AU - Itoyuama, Yasuto. AU - Tabayashi, Koichi. PY - 2001/4/13. Y1 - 2001/4/13. N2 - The mechanism of spinal cord injury has been thought to be related with tissue ischemia, and spinal motor neuron cells are suggested to be vulnerable to ischemia. To evaluate the mechanism of such vulnerability of motor neurons, we attempted to make a reproducible model of rabbit spinal cord ischemia. Using this model, the inductions of phosphatidylinositol 3-kinase (PI3-k) and serine-threonine kinase (Akt) were investigated with immunohistochemical analyses for up to 7 days of the reperfusion following 15 min of ischemia in rabbit spinal cord. It has been demonstrated that both PI3-k and its downstream effector, Akt mediate growth factor-induced neuronal survival. Spinal cord sections from ...
Plasma and cerebrospinal fluid beta-endorphin concentrations were radioimmunologically assayed in dogs subjected to spinal cord ischemia induced by infrarenal aortic ligature and in control sham-operated dogs. Plasma beta-endorphin levels rose significantly following surgery in control dogs but were unaffected by spinal ischemia. On the other hand, a significant increase in cerebrospinal fluid beta-endorphin concentration occurred after spinal ischemia, while surgical stress had no significant effect. Thus, the origins of plasma and cerebrospinal fluid beta-endorphin may be different, with the former secreted from the hypophysis and the latter from nervous tissue. Observed changes in cerebrospinal fluid beta-endorphin concentration could be related to the ischemic lesion of nervous tissue while the changes in plasma levels may reflect general stressing factors such as the surgery in our experiments. ...
TY - JOUR. T1 - Tarlov cysts. T2 - A controversial lesion of the sacral spine. AU - Lucantoni, Corrado. AU - Than, Khoi D.. AU - Wang, Anthony C.. AU - Valdivia-Valdivia, Juan M.. AU - Maher, Cormac O.. AU - La Marca, Frank. AU - Park, Paul. PY - 2011/12/1. Y1 - 2011/12/1. N2 - The primary aim of our study was to provide a comprehensive review of the clinical, imaging, and histopathological features of Tarlov cysts (TCs) and to report operative and nonoperative management strategies in patients with sacral TCs. A literature review was performed to identify articles that reported surgical and nonsurgical management of TCs over the last 10 years. Tarlov cysts are often incidental lesions found in the spine and do not require surgical intervention in the great majority of cases. When TCs are symptomatic, the typical clinical presentation includes back pain, coccyx pain, low radicular pain, bowel/bladder dysfunction, leg weakness, and sexual dysfunction. Tarlov cysts may be revealed by MR and CT ...
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For a complete text of this fact sheet, join NSCIA.. NSCIA, 5/96. This Factsheet is offered as an information service and is not intended to cover all treatments or research in the field nor is it an endorsement of the methods mentioned herein. Any information you may have to offer to further update this Factsheet would be greatly appreciated. The National Spinal Cord Injury Resource Center (NSCIRC) provides information and referral on any subject related to spinal cord injury. Contact the resource center at 1-800-962-9629.. Browse the Fact Sheets. ...
The New Jersey Commission on Spinal Cord Research awarded $549,000 to Trevor Dyson-Hudson, MD, for research on spinal cord injuries.
david asked the Naked Scientists: Hi I had a spinal cord injury.I was curios is this drug called artemin available now,or is there some kind of trial ...
This information is not designed to replace a physicians independent judgment about the appropriateness or risks of a procedure for a given patient. Always consult your doctor about your medical conditions or back problem. SpineUniverse does not provide medical advice, diagnosis or treatment. Use of the SpineUniverse.com site is conditional upon your acceptance of our User Agreement ...
Other questions : I need this protein concentration to do ELISA on these samples. Have anyone tried to do an actin ELISA to know if you have the same amount of protein in all your samples ? The same way you do actin WB to compare your signal for other proteins ...
Study Flashcards On Spinal Cord and reflexes at Cram.com. Quickly memorize the terms, phrases and much more. Cram.com makes it easy to get the grade you want!
Global neurovascular devices market expected to generate around USD 2.89 billion by 2025, at a CAGR of around 5.4% between 2019 and 2025. Neurovascular devices are used to treat neurovascular diseases or disorders. Neurovascular diseases are caused when the blood vessels in the brain or spinal cord function abnormally.
Please join the RARE Portal to add diseases of interest to your personal profile. By creating a profile, you can receive news, resources and updates related to this disease as well as many other benefits. ...
TY - JOUR. T1 - Transient paraplegia after stent grafting of a descending thoracic aortic aneurysm treated with cerebrospinal fluid drainage. AU - Fuchs, Ralph J.. AU - Lee, W. Anthony. AU - Seubert, Christoph N.. AU - Gelman, Simon. AU - Yeager, Anita. PY - 2003/2. Y1 - 2003/2. N2 - We present a case of descending thoracic aortic aneurysm repair using an endovascular stent graft, complicated by postoperative paraplegia, which was successfully treated by placing a spinal drain. The case highlights the importance of the concept of collateral flow to the spinal cord and of choosing an anesthetic technique that allows immediate postoperative evaluation of lower extremity neurologic function.. AB - We present a case of descending thoracic aortic aneurysm repair using an endovascular stent graft, complicated by postoperative paraplegia, which was successfully treated by placing a spinal drain. The case highlights the importance of the concept of collateral flow to the spinal cord and of choosing an ...
Postoperative paraplegia is a devastating complication of inferior descending thoracic (iDTA) and thoracoabdominal aortic aneurysms (TAAA) operation. Despite refinements in surgical technique for spinal protection, the risk of postoperative neurologic deficit remains significant. Postoperative paraplegia in endovascular aortic repair (EVAR) was improved remarkably than conventional operations, but this method has an incidence of 5%. Cerebrospinal fluid drainage (CSFD) and dosage of Naloxone might be effective to protect spinal cord from ischemia. But these adjuncts are not clear yet in EVAR. A purpose of this study is to evaluate the impact of CSFD on the incidence of spinal cord injury after EVAR of iDTA and TAAA. [Method] 625 patients received EVAR from January 1996 to March 2007. In these patients, the cases that stent-graft ending was inserted in periphery ahead of Th12 were 93. The average age was 73.4 years. Preoperative complications included 10 cases of cerebrovascular disorder, 9 cases ...
At the level of compression of the cervical segments may be exposed nerve roots and their arteries, spinal cord and its vessels, the vertebral artery.Compression of the spinal cord is possible due to the back or rear intervertebral hernia osteophytes.By particularly susceptible people with a narrow spinal canal.When compression hernia symptoms of cervical degenerative disc disease develops quickly and the symptoms of the current liquor unit softer.. Clinically distinguish tumor compression and disc herniation of the spinal cord is very difficult.Osteochondrosis of the cervical spine appears spastic paresis foot sensitivity conduction disorders, pain and weakness in the hands.In some cases, signs of compression combined with signs of spinal cord ischemia substances resulting from compression of the spinal and radicular artery vessels.. may suddenly develop symptoms of anterior horn and ventral departments involving the pyramidal tract (anterior spinal artery blood flow).There anterior spinal ...
Isadore Max Tarlov (May 16, 1905 - June 4, 1977) was an American neurosurgeon, academic and researcher. He was the first doctor to provide a methodical description of perineurial cysts of the spinal region, which are now known as Tarlov cysts. Tarlov was born in Norwalk, Connecticut, to Russian Jewish immigrant parents. He graduated from Clark University and earned his medical degree from Johns Hopkins University in 1930. During World War II, Tarlov researched the use of blood plasma clotting agent as an adhesive to repair nerve cells. Tarlov first noticed the cysts while doing a postmortem examination of 30 filum terminale specimens in 1938, and he published his findings in the Archives of Neurology & Psychiatry. He initially believed the cysts were the result of meningeal diverticula and long arachnoid prolongations. It wasnt until 10 years later that he discovered their significance, and that these cysts can appear symptomatic in patients. An important distinguishing factor is that the walls ...
Since its introduction by Michael DeBakey in 1956,1 thoracoabdominal aneurysm (TAA) repair generally presents the most technically challenging and controversial issues in vascular surgery. The surgical repair of TAAs is an undertaking that requires substantial preoperative planning and consideration of a wide array of techniques. Each of these techniques has its champions, and several authors have published comparably good results using widely different methods. In this chapter, the common principles that are applicable to all TAA surgery are described. In addition, most of the surgical techniques currently in use to repair these aneurysms are discussed, with emphasis on those that are preferred at the Johns Hopkins Hospital. ...
We find that spinal cord injury as a result of falls is a major public health issue in the older patients, and we need to find what the causes for that are and appropriately design interventions," he said.. Jain noted that one in five with such injuries dies in the hospital.. Before the study, there was limited data on trends of the incidence and cause of spinal cord injury. Researchers discovered that while incidence rates among the younger male population dropped over about 20 years, rates for men ages 65 to 74 jumped to 131 cases per million from 84 cases per million.. "We dont really know the exact reasons for why there is an increased incidence of falls that cause spinal cord injury," he said, but noted that "older adults are likely much more active now, putting them at a higher risk.". For example, 70-year-olds today may be more likely to go skiing than 70-year-olds would have 20 years ago.. "We also find that the portion of patients who have surgical procedures is also increasing over ...
Tarlov cysts are abnormal sacs of spinal fluid that usually form at the lower end of the spine, which is called the sacrum. Tarlov cysts contain spinal nerve fibers within the cyst wall.
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A 24-year-old man was transferred to the accident and emergency department with generalised seizures. He complained of headache, blurred vision and low backache after recreational cocaine use over the preceding few days. His condition deteriorated rapidly. He developed bilateral leg weakness, and his urine output had tailed-off. His blood pressure was 240/130 mm Hg. Clinical examination revealed global lower limb weakness (4 out of 5), with spastic tone bilaterally. His knee and ankle joint reflexes were … ...
Abstract : We report the case of a patient admitted to our intensive care unit in the course of a septic shock, secondary to cholangitis. After rapid hemodynamic stabilization, antibiotherapy, and end...