Therapeutic hypothermia is already widely acknowledged as an effective neuroprotective intervention, especially within the acute care setting in relation to conditions such as cardiac arrest and neonatal encephalopathy. Its multifactorial mechanisms of action, including lowering metabolic rate and reducing acute inflammatory cellular processes, ultimately provide protection for central nervous tissue from continuing injury following ischaemic or traumatic insult. Its clinical application within acute traumatic spinal cord injury would therefore seem very plausible, it having the potential to combat the pathophysiological secondary injury processes that can develop in the proceeding hours to days following the initial injury. As such it could offer invaluable assistance to lessen subsequent sensory, motor and autonomic dysfunction for an individual affected by this devastating condition. Yet research surrounding this interventions applicability in this field is somewhat lacking, the majority ...
GlobalDatas clinical trial report, "Traumatic Spinal Cord Injury Global Clinical Trials Review, H2, 2014" provides data on the Traumatic Spinal Cord Injury clinical trial scenario. This report provides elemental information and data relating to the clinical trials on Traumatic Spinal Cord Injury. It includes an overview of the trial numbers and their recruitment status as per the site of trial conduction across the globe. The databook offers a preliminary coverage of disease clinical trials by their phase, trial status, prominence of the sponsors and also provides briefing pertaining to the number of trials for the key drugs for treating Traumatic Spinal Cord Injury. This report is built using data and information sourced from proprietary databases, primary and secondary research and in-house analysis by GlobalDatas team of industry experts ...
The extent of injury is defined by the American Spinal Injury Association (ASIA) Impairment Scale (modified from the Frankel classification), using the following categories:{ref1}{ref2} A = Complete:... more
Director, Spinal Cord Injury Rehabilitation Program. People often ask me when or if there will ever be a cure for spinal cord injury. Although there are many differing opinions about this, I am confident there will be a cure in my lifetime. In the meantime, anyone with a spinal cord injury should have a long-term plan for their treatment and care.. The number of spinal cord injuries per year has remained fairly stable over the last two decades, with nearly 12,000 occurring each year mostly from sports injuries, car accidents and other forms of traumatic injury. Currently in the United States there are approximately 200,000 people are living with spinal cord injuries or spinal dysfunction. With todays advanced medical treatments, more spinal cord injury patients survive the trauma compared to just a few decades ago. This positive shift in mortality rate underlines the great importance of initial acute treatment and follow up rehabilitation.. Treatment for spinal cord injuries can be divided into ...
Any type of spinal cord injury is one that can alter your life in many ways. For this reason, its important to do two things:. - Pay close attention to the health of your spinal cord.. - Receive immediate medical treatment if your spinal cord is injured in any way.. With an incomplete spinal cord injury, its difficult to know what the future will bring. However, there are several things you should know about this:. - Spinal cord injuries that do not cause complete paralysis are those with which there is a greater chance of additional recovery in the future.. - When a person still has sensation in the lower part of his or her body, there is a chance that he or she could experience some muscle recovery.. - The sooner muscles begin to work after an incomplete spinal cord injury, the better chance there is that the person will experience additional recovery, especially as it pertains to walking.. While these are some of the most important facts associated with an incomplete spinal cord injury, ...
Severe spinal cord injury is a very debilitating injury. This report presents information from the Australian Spinal Cord Injury Register on 381 cases from trauma and disease in 2004-05. During the year, 280 new cases of spinal cord injury from traumatic causes were registered in Australia, an age-adjusted incidence rate of 15.4 cases per million population. The most common clinical outcome of spinal cord injury was incomplete tetraplegia. Falling was the most common type of event leading to traumatic spinal cord injury at older ages. The Australian Spinal Cord Injury Register is a collaborative activity of the AIHW National Injury Surveillance Unit and all of the specialist spinal units in Australia.. ...
Bodily Function Control : Students with a spinal cord injury may have bodily control difficulties due to nerve damage in the spinal cord. Breathing Difficulty : Students with spinal cord injuries may have breathing difficulties due to an inability to breathe deeply. Climate Sensitivity : Students with spinal cord injury have difficulty with regulating body temperature in hot and cold weather which can cause muscle spasms, heat stroke and frost bite. Fatigue (Physical) : Students with spinal cord injuries may experience physical fatigue due to breathing issues, mobility issues, low blood pressure, or chronic pain. Motor Skill (Fine) : Spinal cord injuries can lead to decreased fine motor skill ranging from some lack of strength and control to full paralysis of fingers. Motor Skill (Gross Lower) : Students with a spinal cord injury may experience muscle spasms, especially in the heat. Motor Skill (Gross Upper) : Students with a spinal cord injury may have difficulty with muscle control or ...
While research in animal models of spinal cord injury have provided many promising insights, human studies have failed to produce effective therapies. We propose to investigate the drug Minocycline (a metalloproteinase inhibitor) for the treatment of spinal cord injured patients aiming to limit neurological injury and improve neurological outcome. This drug influences several secondary injury mechanisms implicated in spinal cord injury and has been effective in improving outcome after spinal cord injury in animal models. We also propose to examine the safety and feasibility of spinal cord perfusion pressure augmentation with a protocol of IV fluids and inotrope medications versus standard maintenance of mean arterial pressure in subjects who exhibit a decrease in perfusion pressure to less than 75 mmHg. The purpose of this pilot study is 1) to evaluate the feasibility of a clinical trial protocol for Minocycline in patients with acute spinal cord injury, and 2) to ensure adequate drug dosing and ...
OBJECTIVE: To map the impact of spinal cord lesion (SCL) on medication. STUDY DESIGN: Registration of medication for 72 patients before SCL and at discharge from the Department for Spinal Cord Injuries. SETTING: Department for Spinal Cord Injuries, East Denmark. METHODS: The changes in medication for each Anatomical Therapeutic Chemical (ATC) Classification System group were registered for all patients, who were discharged from Department for Spinal Cord Injuries during 2010. The changes in medication per se were calculated for different parts of the population: non-traumatic, traumatic patients, men, women, paraplegia, tetraplegia, American Spinal Injury Association Impairment Scale (AIS) A, B or C, AIS D, age 0-45, 46-60 and 60+. In addition, comparisons of changes in medication were made between complementary parts of the population. RESULTS: The overall increase in medication after SCL was 3.29 times (P,0.001). Statistically significant increases were seen for most medicine categories. When ...
Health conditions in people with spinal cord injury are major determinants for disability, reduced well-being, and mortality. However, population-based evidence on the prevalence and treatment of health conditions in people with spinal cord injury is scarce.; To investigate health conditions in Swiss residents with spinal cord injury, specifically to analyse their prevalence, severity, co-occurrence, and treatment.; Cross-sectional data (n = 1,549) from the community survey of the Swiss Spinal Cord Injury (SwiSCI) cohort study, including Swiss residents with spinal cord injury aged over 16 years, were analysed. Nineteen health conditions and their self-reported treatment were assessed with the spinal cord injury Secondary Conditions Scale and the Self-Administered Comorbidity Questionnaire. Prevalence and severity were compared across demographics and spinal cord injury characteristics. Co-occurrence of health conditions was examined using a binary non-metric dissimilarity measure and ...
While the recommendations for spinesurgery in specific cases of acute traumatic spinal cord injury (SCI) are well recognized, there is considerable uncertainty regarding the role of the timing of surgical decompression of the spinal cord in the management of patients with SCI. Given this, we sought to critically review the literature regarding the pre-clinical and clinical evidence on the potential impact of timing of surgicaldecompression of the spinal cord on outcomes after traumatic SCI. The primary literature search was performed using MEDLINE, CINAHL, EMBASE, and Cochrane databases. A secondary search strategy incorporated articles referenced in prior meta-analyses and systematic and nonsystematic review articles. Two reviewers independently assessed every study with regard to eligibility, level of evidence, and studyquality. Of 198 abstracts of pre-clinical studies, 19 experimental studies using animal SCI models fulfilled our inclusion and exclusion criteria. Despite some discrepancies ...
spinal cord injuries - MedHelps spinal cord injuries Center for Information, Symptoms, Resources, Treatments and Tools for spinal cord injuries. Find spinal cord injuries information, treatments for spinal cord injuries and spinal cord injuries symptoms.
Study design: Retrospective analysis of medical records on spinal cord injury (SCI) patients with neuropathic bladder.Objective: To determine SCI patients compliance with the method of bladder management they used on discharge from inpatient rehabilitation.Setting: Ankara University Medical School, Department of Physical Medicine and Rehabilitation, Spinal Cord Injury Unit, which treats patients referred from throughout Turkey.Methods: The bladder management method of 50 new SCI patients was noted at admission, discharge and follow-up. Reasons for changing the initial method were documented. For analysis, patients were grouped by gender, level and completeness of injury. Compliance with bladder management method was compared between these groups by chi-square test.Results: The method of bladder management at admission was indwelling catheter (IC) for 86% of the patients. Most were switched to clean intermittent catheterisation (CIC) by rehabilitation discharge. Of 38 patients (76%) on CIC at discharge,
A spinal cord injury can entail anything from persistent nerve damage leading to tingling in the legs to permanent and full paralysis. Serious spinal cord injuries can require extensive physical and occupational therapy. Multiple complicated surgeries may also be needed. This can all lead to extensive medical bills and lost wages. The long and difficult road to recovery can impact every aspect of your life, from family to career and beyond. For some, a permanent and severe spinal cord injury can mean an end to any career or chance of employment in a field they may have spent years preparing for. If a spinal cord injury victim is paralyzed, expensive modifications to the home and vehicles may also be needed.. Resources: Spinal Cord Injury Statistics. ...
Few injuries result in more profound and long-term disability than traumatic spinal cord injury. This study describes the demographic and epidemiologic characteristics of traumatic spinal cord injury among Oklahoma residents reported to the statewide, population-based surveillance system in 1988-1990; initial acute hospital and rehabilitation...
References. 1. White CC 4th, Domeier RM, Millin MG; Standards and Clinical Practice Committee, National Association of EMS Physicians. EMS spinal precautions and the use of the long backboard-Resource document to the position statement of the National Association of EMS Physicians and the American College of Surgeons Committee on Trauma. Prehosp Emerg Care, 2014 Apr-Jun; 18(2): 306-14.. 2. Devivo MJ. Epidemiology of traumatic spinal cord injury: Trends and future implications. Spinal Cord, 2012 May; 50(5): 365-72.. 3. Ropper AE, Neal MT, Theodore N. Acute management of traumatic cervical spinal cord injury. Pract Neurol, 2015 Aug; 15(4): 266-72.. 4. Hansebout RR, Kachur E. Acute traumatic spinal cord injury. UpToDate, www.uptodate.com/contents/acute-traumatic-spinal-cord-injury.. 5. Theodore N, Hadley MN, Aarabi B, et al. Prehospital cervical spine immobilization after trauma. Neurosurgery, 2013 Mar; 72 Suppl 2: 22-34.. 6. Haut ER, Kalish BT, Efron DT, et al. Spine immobilization in penetrating ...
Jennifer Coker, MPH, has been a Research Associate at Craig Hospital since April 2012 and works primarily with the SCI Model Systems projects. She is Principal Investigator for the current SCI Model Systems module project, "Utilization of Complementary and Integrative Healthcare to Treat Pain in Persons with Spinal Cord Injury" and a Craig H Neilsen Foundation-funded project, "A Bridge from Rehabilitation to Real-World: Reinventing Yourself after SCI.". Ms. Coker has worked in the field of traumatic spinal cord injury (SCI) since 1997. She obtained a Master of Public Health (MPH) from the Rollins School of Public Health at Emory University in May 2001 where she won the James W. Alley Award for Outstanding Service to Disadvantaged Populations. Ms. Coker is currently a PhD student in the Clinical Sciences program at the University of Colorado-Anschutz Medical Campus. She has presented research at national conferences of the American Spinal Injury Association, the American Association of Spinal ...
Management of the neurogenic bladder has the primary objectives of maintaining continence, ensuring low bladder pressure (to avoid renal damage) and avoiding or minimising infection. Options include intermittent urethral catheterisation, indwelling urethral or suprapubic catheterisation, timed voiding, use of external catheter (for men), drug treatment, augmentation cystoplasty and urinary diversion. [1] Long-term indwelling urethral catheterisation is common amongst people with cervical spinal cord injury; however, this carries a high risk of developing a catheter-related urinary tract infection and associated complications especially bypassing and leakage. [2, 3]. Carers and health professionals tend to assume that urethral catheter drainage is satisfactory in spinal cord injury patients if the catheter is draining clear urine, there is no blood in urethral meatus, and the patient does not develop features of autonomic dysreflexia. In male spinal cord injury patients, the balloon of a Foley ...
The Covid-19 pandemic has been an unprecedented time for all, with or without disability. Persons with spinal cord injury are more vulnerable than others, and were left to fear severe complications and poor disease outcome. When confronted with protective measures and a lockdown, the physical, psychological and social needs of those persons in a wheelchair cannot be overstated. Thats why this year focus Spinal Cord Injury Day 2020 will be on the prevention of Covid-19 for persons with spinal cord injury, with the slogan "Covid-19 and SCI: Staying well".. According to World Health Organization (WHO) between 2,50,000 and 5,00,000 people suffer a spinal cord injury (SCI) around the world, every year. Most of the spinal cord injuries are due to the avoidable reasons such as road accidents, falls or violence. As per the statistics from USA, depending on the severity, SCI can cost an injured individual USD 334,000 to 1 million in the first year after injury. Costs in each subsequent year range from ...
Spinal cord injuries are either complete or incomplete. A complete spinal cord injury causes a total loss of function below the injury. For this reason, a complete SCI in the neck results in a loss of function of all limbs and the torso (quadriplegia/tetraplegia), while the same injury in the middle or lower back results in a loss of function of part of the torso and the legs (paraplegia). An incomplete SCI may result in pain to partial paralysis and anything in between. Unfortunately, medical advances in this area have been modest. Thanks to new rehabilitation techniques, a complete SCI may convert to an incomplete SCI, but whether the injury is complete or incomplete, the effect on quality of life is always significant.. The lawyers at Litwiniuk & Company have comprehensive experience negotiating on behalf of clients who have suffered spinal cord injuries. We know there will be extensive costs for medical treatment and rehabilitation, wheelchairs or other mobility aids, and even home ...
Movement is planned and coordinated by the brain and carried out by contracting muscles acting on specific joints. Motor commands initiated in the brain travel through descending pathways in the spinal cord to effector motor neurons before reaching target muscles. Damage to these pathways by spinal cord injury (SCI) can result in paralysis below the injury level. However, the planning and coordination centers of the brain, as well as peripheral nerves and the muscles that they act upon, remain functional. Neuroprosthetic devices can restore motor function following SCI by direct electrical stimulation of the neuromuscular system. Unfortunately, conventional neuroprosthetic techniques are limited by a myriad of factors that include, but are not limited to, a lack of characterization of non-linear input/output system dynamics, mechanical coupling, limited number of degrees of freedom, high power consumption, large device size, and rapid onset of muscle fatigue. Wireless multi-channel closed-loop
This submission demonstrates the unique contribution made by my research to our understanding of physiological responses and their regulation during exercise and heat stress in individuals with traumatic spinal cord injury, and thus that I have met the conditions required for the award of PhD by Publication.This submission demonstrates the unique contribution made by my research to our understanding of physiological responses and their regulation during exercise and heat stress in individuals with traumatic spinal cord injury, and thus that I have met the conditions required for the award of PhD by Publication ...
Spinal Cord Injury Ring,This ring contains web pages that pertain exclusively to spinal cord injury, spinal cord injury resources, and spinal cord injury rehabilitation facilities.
Extensive oligodendrocyte death after acute traumatic spinal cord injuries (TSCI) leads to axon demyelination and subsequently may leave axons vulnerable to degeneration. Despite the present evidence showing spontaneous remyelination after TSCI the cellular origin of new myelin and the time course of the axon ensheatment/remyelination remained controversial issue. In this systematic review the trend of oligodendrocyte death after injury as well as the extent and the cellular origin of oligodendrogliogenesis were comprehensively evaluated. The study design was based on Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA)-guided systematic review. PubMed and EMBASE were searched with no temporal or linguistic restrictions. Also, hand-search was performed in the bibliographies of relevant articles. Non-interventional animal studies discussing different types of myelinating cells including oligodendrocytes, Schwann cells and oligodendrocyte progenitor cells (OPCs) were ...
WXXIs national health care series Second Opinion tells two personal stories about devastating spinal cord injuries.. Dr. Brad Berk, the CEO of the University of Rochester Medical Center shares the story of the bicycle accident that left him in a wheelchair, and Charlie Durkee also joins in the conversation, as he shares the trials he has faced since his accident which left him paralyzed at the age of 22. Second Opinion: Spinal Cord Injury airs Wednesday, January 19 at 3 p.m. on WXXI-TV/HD (DT21.1/cable 1011 and 11).. Each year, more than 11,000 Americans will experience a similar injury, often causing permanent disability or paralysis. Advances in research may someday make the repair of spinal cord injuries possible, but current treatments and rehabilitation allow many people to lead productive, independent lives.. Dr. Berk joins panelists Dr. David Chen, Medical Director of the Spinal Cord Injury Program at the Rehabilitation Institute of Chicago and Dr. Paul Maurer, a neurosurgeon at the ...
... can be completely devastating and severely impacts the lives of everyone that surrounds the injured individual. Michael Lamson has practiced personal injury law for over 35 years and represents clients who have experienced spinal cord injury.. Spinal cord injury occurs when a body has sustained damage to the spinal column, causing paralysis, loss of motor control and sensation. A person with spinal injury can be paraplegic with loss of sensation/motor control of legs, or quadriplegic with loss of sensation/control of all limbs. Not only is a spinal cord injury permanently disabling, it also makes a person even more susceptible to serious health problems due to lack of control of essential body functions like breathing, control of bladder, body temperature and more.. Call Michael Lamson if you have experienced a spinal cord injury as the result of the following:. ...
Task-Specificity for Incomplete Spinal Cord Injury. T. George Hornby PhD, Principal Investigator. This study is a randomized controlled trial for patients with a motor incomplete spinal cord injury directed towards understanding the relative contributions of specificity of training to improve locomotor function. We are recruiting ambulatory individuals with a motor incomplete SCI of at least 1 year duration.. Contact: Chris Henderson. Email: [email protected] Phone: 317-329-2353. ...
The aim of this study was to determine the efficacy and the effects of functional electrical stimulated cycling (FES cycling) in patients with spinal cord injury during their rehabilitation in a special acute care unit. Thirty patients [10 with American Spinal Injury Association Impairment Scale (AIS) grade A, three with AIS grade B, 15 with AIS grade C, two with AIS grade D] aged 44±15.5 years and 2 (median) (interquartile range, 1.0-4.25) months after spinal cord injury were included in the study. The patients participated in a 20-min FES-cycling program 2 days per week for 4 weeks during their acute inpatient rehabilitation ...
Spinal cord injuries generally result from trauma to the spinal column. The force can fracture or dislocate vertebrae - the bone segments in the back. And spinal cord tissue is damaged. A wide range of symptoms can be experienced, depending on the severity and location. Some spinal injury victims can expect full recovery with rehabilitation. Other injuries are more serious and can result in paralysis. In either case, rehabilitation is important to treatment and repair. In addition to limiting mobility, spinal cord injuries can result in additional issues, such as respiratory problems. HealthSouth has all the resources needed for specialized spinal cord injury care. The team approach puts the right experts and therapies together for the best possible outcome, focused on:. ...
Mesenchymal Stem Cells in the Treatment of Patients with Chronic Spinal Cord Injury (ASIA A) with Residual Electrophysiological Function. Vocational Decision-Making and Rehabilitation Following Paediatric Traumatic Spinal Cord Injury: An Illustrative Case Study Analysis. Articles related to spinal cord injury are open access to read here.
A life-threatening disability after complete spinal cord injury is urinary dysfunction, which is attributable to lack of regeneration of supraspinal pathways that control the bladder. Although numerous strategies have been proposed that can promote the regrowth of severed axons in the adult CNS, at present, the approaches by which this can be accomplished after complete cord transection are quite limited. In the present study, we modified a classic peripheral nerve grafting technique with the use of chondroitinase to facilitate the regeneration of axons across and beyond an extensive thoracic spinal cord transection lesion in adult rats. The novel combination treatment allows for remarkably lengthy regeneration of certain subtypes of brainstem and propriospinal axons across the injury site and is followed by markedly improved urinary function. Our studies provide evidence that an enhanced nerve grafting strategy represents a potential regenerative treatment after severe spinal cord injury. ...
Research suggests that combining therapies could result in important gains in restoring function and improving quality of life in persons with spinal cord injury (SCI). Locomotor training is an activity-dependent rehabilitation therapy that provides repetitive stepping facilitated by manual assistance and body weight support on a treadmill. Recent studies report improvements in walking and standing in individuals with motor incomplete SCI that have undergone intensive standardized locomotor training therapy. Extended release dalfampridine (also known as fampridine or 4-aminopyridine [4-AP]) is a broad spectrum potassium channel blocker that has been shown in animal studies to increase conduction of action potentials in demyelinated axons. Dalfampridine was recently approved by the U.S. Food and Drug Administration (FDA) as a treatment to improve walking in persons with multiple sclerosis (MS). Demyelination is also a prominent feature of incomplete SCI that contributes to the clinical ...
TY - JOUR. T1 - Increased cardiovascular disease risk in Swedish persons with paraplegia. T2 - The Stockholm spinal cord injury study. AU - Wahman, Kerstin. AU - Nash, Mark S. AU - Lewis, John E. AU - Seiger, Ake. AU - Levi, Richard. PY - 2010/5/1. Y1 - 2010/5/1. N2 - Objective: Comparison of prevalence of cardiovascular disease risks in persons with chronic traumatic paraplegia with those in the general population. Design: Cross-sectional comparative study. Subjects: A total of 135 individuals, age range 18-79 years, with chronic (≥1 year) traumatic paraplegia. Methods: The prevalences of diabetes mellitus, dyslipidaemia, hypertension, overweight, and smoking, were assessed in the study population and were compared with an age-and gender-matched sample of the general population in the region under study. History of myocardial infarction and medication for dyslipidaemia, hypertension, and diabetes mellitus were also recorded, χ2 tests were used to compare the paraplegic cohort with the ...
We specialize in the treatment of pediatric spinal cord injuries and dysfunction, including spina bifida; traumatic, complete and incomplete spinal cord injury; tethered cord; and more.
The Hong Kong Spinal Cord Injury Fund Ltd. (HKSCIFund) is a registered charitable organization in Hong Kong (Registered Charity Number: 918370). The sole function of the HKSCIFund is to support the China Spinal Cord Injury Network. The ChinaSCINet is the largest spinal cord injury clinical trial network in the world, comprising more than 20 leading spinal cord injury centers in Mainland China, Hong Kong and Taiwan. It has been established to develop and test the most promising therapies for spinal cord injury and aims at accelerating movement of therapies from laboratory to clinic. 「香港脊髓損傷基金會有限公司」是香港認可的慈善機構(政府慈善機構註冊號碼:918370)。籌募所得將全數支持「中國脊髓損傷研究協作組」。 「中國脊髓損傷研究協作組」是全球最大的脊髓損傷臨床試驗網絡,由二十多家在中國大陸、香港及台灣具領導地位的脊髓損傷中心組成
The Hong Kong Spinal Cord Injury Fund Ltd. (HKSCIFund) is a registered charitable organization in Hong Kong (Registered Charity Number: 918370). The sole function of the HKSCIFund is to support the China Spinal Cord Injury Network. The ChinaSCINet is the largest spinal cord injury clinical trial network in the world, comprising more than 20 leading spinal cord injury centers in Mainland China, Hong Kong and Taiwan. It has been established to develop and test the most promising therapies for spinal cord injury and aims at accelerating movement of therapies from laboratory to clinic. 「香港脊髓損傷基金會有限公司」是香港認可的慈善機構(政府慈善機構註冊號碼:918370)。籌募所得將全數支持「中國脊髓損傷研究協作組」。 「中國脊髓損傷研究協作組」是全球最大的脊髓損傷臨床試驗網絡,由二十多家在中國大陸、香港及台灣具領導地位的脊髓損傷中心組成
Located at the Spain Rehabilitation Center in Birmingham, AL, the UAB Spinal Cord Injury Model System offers individualized care for both adolescents and adults with an emphasis on family participation in the recovery process. Patients families are encouraged to attend therapy education sessions to improve
When potentially life-altering injury occurs, coordinated, compassionate care and the support of clinicians dedicated to pioneering improved therapies can make all the difference to your immediate and long-term recovery. Within our Rehabilitation Network, supporting your return to an active, productive and fulfilling life is the goal behind everything we do.. The hub of our Spinal Cord Injury Rehabilitation (SCI) program is the Spaulding New England Regional Spinal Cord Injury Center (SNERSCIC), led by SCI experts at Spaulding Boston, a Center of Excellence in SCI rehabilitation. With the guidance of our physicians and other rehabilitation specialists and with access to some of the most advanced technologies available today, you will have the resources to reach your highest level of recovery - and find successful, enriching ways to live independently. ...
Potential role of stem cells in severe spinal cord injury: current perspectives and clinical data Syed AB Paspala,1,2 Sandeep K Vishwakarma,1 Tenneti VRK Murthy,2 Thiriveedi N Rao,2 Aleem A Khan11PAN Research Foundation, CARE, 2The Institute of Medical Sciences, Hyderabad, IndiaAbstract: Stem cell transplantation for spinal cord injury (SCI) along with new pharmacotherapy research offers the potential to restore function and ease the associated social and economic burden in the years ahead. Various sources of stem cells have been used in the treatment of SCI, but the most convincing results have been obtained with neural progenitor cells in preclinical models. Although the use of cell-based transplantation strategies for the repair of chronic SCI remains the long sought after holy grail, these approaches have been to date the most successful when applied in the subacute phase of injury. Application of cell-based strategies for the repair and regeneration of the chronically injured spinal cord will
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
New research published in the New England Journal of Medicine documents the effectiveness of epidural stimulation with locomotor training following chronic, complete spinal cord injury in restoring brain-to-spine connectivity, long thought to be impossible. EDITORS NOTE: Download video story, broadcast quality b-roll and sound bites for this story at the links. Additional photos also are available on request.. LOUISVILLE, Ky. - Of four research participants living with traumatic, motor complete spinal cord injury, two are able to walk over ground with epidural stimulation following epidural stimulation paired with daily locomotor training. In addition, all four participants achieved independent standing and trunk stability when using the stimulation and maintaining their mental focus. The study was conducted at the Kentucky Spinal Cord Injury Research Center at the University of Louisville (UofL) and was published online early, and will appear in the Sept. 27 issue of New England Journal of ...
When the Good Lord made the human being, He gave us a very important piece of equipment- the spinal cord. It is an incredibly intricate, detailed and multi-facted part of our body.. Damage to the spinal cord can be a very big deal, that can have life-long ramifications.. I can help if your spinal cord has been injured as the result of anothers carelessness.. Spinal cord injuries occur when the spine (or rather, the discs and nerve tissues within the spine) become damaged, usually due to excessive force or some type of trauma. A large majority of spinal cord injuries occur as the result of some type of accident, such as auto accidents, motorcycle accidents, truck accidents, pedestrian accidents, bicycle accidents, slip and falls (due to dangerous property conditions), and more.. If you were injured or involved in an accident, and as a result have sustained a spinal cord injury, its to your advantage to speak with a skilled injury attorney right away. Spinal cord injuries can result in a number ...
We have shown previously that mats made from the glycoprotein fibronectin are permissive for axonal growth when implanted into the injured spinal cord. Recent evidence has indicated that fibronectin and its peptides also have neuroprotective effects in the CNS. We have therefore examined the neuroprotective effects of fibronectin applied to a spinal cord injury site. Adult rats with fibronectin mats implanted into a spinal cord lesion cavity had decreased apoptosis in the intact adjoining spinal cord tissue at 1 and 3 days post-injury compared to rats that had gelfoam implanted into the lesion cavity. Rats with fibronectin mat implants also showed enhanced hindlimb locomotor performance for the first 3 weeks post-surgery compared to control animals. To further examine the neuroprotective potential of fibronectin following spinal cord injury, we examined the effects of placing fibronectin mats over the site of a spinal cord hemisection or of delivering a solution derived from a dissolved ...
A spinal cord injury is an injury that causes the accident victims spinal cord to sever - either fully or partially - resulting in a limited or permanent inability to function. One of the primary consequences of a spinal cord injury is full or partial paralysis. Spinal cord injuries often come about when the accident victim strikes his or her neck or back on the ground in an accident. Motorcycle and bicycle accident victims are especially prone to spinal cord injuries because the neck and back are not covered by a helmet and are at least partially exposed to the impact. If you or a loved one suffered a spinal cord injury, an Atlanta spinal injury attorney might be able to help you recover damages. ...
This is the most bottom section of the spinal cord, and injuring it may have almost the same symptoms from the lumbar section. Bladder and bowel movement problems may arise, and the lower limbs may be compromised. The difference is that those who have suffered injuries in this section have higher chances of being able to walk.. Aside from the pain and suffering from spinal cord injuries, you can also lose significant time at work or school. Worse, you can lose your ability to work. This just proves that spinal cord injuries are seriously damaging.. According to the website of the Benton Law Firm, those who have sustained spinal cord injuries because of somebody else may get compensation from that guilty party. It is good to know that the law is on the side of the victims, but at the end of the day, money is not enough to offset the damages of spinal cord injuries.. ...
Spinal cord injury related neuropathic pain has proven to be largely refractory to analgesic medications & other treatments. Alpha-Stim has been effective.
As someone who has faced a spinal cord injury, I can tell you that the difference between surviving and thriving is support," said Adam Taliaferro, founder of the Adam Taliaferro Foundation and former patient of Magee Rehabilitation Hospital. "The Golf Outing is my way of giving back, of bolstering the research, rehab and programs that helped me, to ensure all people with spinal cord injuries have the same opportunities that made my recovery so successful.". A cornerback for Penn State University, Adam sustained a spinal cord injury on the football field in 2000 while making a clean hit in a game against Ohio State. Told by doctors he may never walk again, Adam came to Magee for his rehabilitation and walked out of the hospital just months later. He founded the Adam Taliaferro Foundation to provide emotional, financial and educational support to individuals who have sustained a catastrophic head or spinal cord injury in sanctioned team events in New Jersey, Pennsylvania or Delaware. "Adam ...
TY - JOUR. T1 - Critical role of connexin 43 in secondary expansion of traumatic spinal cord injury. AU - Huang, Chunlan. AU - Han, Xiaoning. AU - Li, Xi. AU - Lam, Eric. AU - Peng, Weiguo. AU - Lou, Nanhong. AU - Torres, Arnulfo. AU - Yang, Meixiang. AU - Garre, Juan Mauricio. AU - Tian, Guo Feng. AU - Bennett, Michael V.L.. AU - Nedergaard, Maiken. AU - Takano, Takahiro. PY - 2012/3/7. Y1 - 2012/3/7. N2 - Spinal cord injury (SCI) is often complicated by secondary injury as a result of the innate inflammatory response to tissue trauma and swelling. Previous studies have shown that excessive ATP release from peritraumatic regions contributes to the inflammatory response to SCI by activation of low-affinity P2X7 receptors. Because connexin hemichannels constitute an important route for astrocytic ATP release, we here evaluated the impact on post-traumatic ATP release of deletion of connexins (Cx30/Cx43) in astrocytes. In vivo bioluminescence imaging showed a significant reduction in ATP release ...
Spinal cord injuries are usually a result of car crashes, motorcycle accidents, and sports related injuries and the lasting effects can be life altering for the injured. Some of the post accident side effects can include respiratory problems, spasms, urinary tract infections, and permanent curvature in the spine. The resulting damage of spinal cord trauma is usually numbness and/or paralysis. The vertebrate number has everything to do with the location and severity of the injury that follows spinal cord trauma. In some severe injury cases can result in a condition known as tetraplegia. Tetraplegia causes little or no sensation in a persons hands or legs. There are some procedures that are being practiced that in some cases can restore hand function after a spinal cord injury, but as with any kind of surgery there are risks and varying levels of success and realistic outcomes.. Tetraplegia. Tetraplegia is when a victim has lost feeling and use of both arms and legs, as a result of permanent ...
In December 2010 the Swiss regulatory agency for therapeutic products approved a StemCell Inc. sponsored Phase I/II clinical trial on chronic spinal cord injury at the Balgrist University Hospital in Zurich (Switzerland). The trial used specific stem cells derived from human brain tissue (neural stem cell or NSCs), which can make any of the three major kinds of neural cells found in the central nervous system. The trial was based on preclinical evidence that oligodendrocyte cells were replaced after transplanting human NSCs into in a particular mouse model for spinal cord injuries. For the trial, human NSCs (specifically referred to as Human Central Nervous System Stem Cells or HuCNS-SC) were directly implanted into the spinal cord of patients with complete and incomplete chronic thoracic spinal cord injuries. This trial was officially completed in June 2015 (clinicaltrials.gov identifier no. NCT01321333). In 2012 a further Phase I/II clinical study of HuCNS-SC cell transplantation was started ...