Ceramide synthase 5 (CerS5) is the enzyme encoded in humans by the CERS5 gene. CerS5 robustly synthesizes C16-ceramide, which is often considered to be an important pro-apoptotic ceramide. De novo ceramide synthesis is an essential trigger for Bax activation in hypoxia/reoxygenation. Following hypoxia/reoxygenation, CerS5 expression is elevated. Upon knocking down acid sphingomyelinase and CerS5 in NTERA-2 cells, Bax localization to mitochondria was reduced, indicating the importance of CerS5 activity in the apoptosis pathway. CerS5 (TRH4) mRNA is found in all tissues and is strongly expressed in muscle and brain. CerS5 is the major ceramide synthase detected in lung epithelia. Knock-down research in respiratory epithelium using CerS5 siRNA or fumonisin B1 reduced total CerS activity by 45% or 78%, respectively, indicating that CerS5 indeed contributes significantly to ceramide synthesis in lung. In the brain, CerS5 mRNA is detected in most cells within the gray and white matter tissues. CerS5 ...

Ceramide synthase 3 (CersS3), also known as longevity assurance homologue 3, is an enzyme that is encoded in humans by the CERS3 gene. CerS3 synthesizes C24-ceramides and ceramides with longer acyl chains, and is found mainly in skin and testis. Specifically, CerS3 synthesizes ceramides containing α-hydroxy (2-hydroxy) fatty acids, which are abundant in skin tissue, where they help maintain the water permeability barrier qualities of the skin. It is found in large quantities in keratinocytes, and this increases during keratinocyte differentiation. In the testes, CerS3 is involved in sperm formation and androgen production. Cers3 gene expression is located within germ cells, where it is massively upregulated during juvenile testicular maturation. This upregulation is correlated with increase in levels of glycosphingolipids containing very long chain (C26-C32) polyunsaturated fatty acid (LC-PUFA), which are required for spermatogenesis. CerS3 (T3l) mRNA is strongly expressed in skin, and was also ...

AIMS/HYPOTHESIS: An accumulation of ceramides has been implicated in the generation of insulin resistance in skeletal muscle upon an oversupply of fatty acid. Different ceramide species are generated through the actions of ceramide synthases (CerSs), which incorporate specific acyl side chains. We tested whether particular CerS isoforms promoted insulin resistance through the generation of more inhibitory ceramide species, thus representing potential targets for intervention. METHODS: CerS isoforms CerS1, CerS2, CerS4, CerS5 and CerS6 were overexpressed in L6 myotubes using adenovirus, and cells were treated with palmitate and stimulated with insulin. Alternatively, CerS isoforms were knocked down using siRNAs. Sphingolipids were examined by mass spectrometry and tracer incorporation. Phosphorylation of IRS1 and Akt was measured by immunoblotting, while glucose disposal was assessed by measuring GLUT4 translocation and the incorporation of [(14)C]glucose into glycogen. RESULTS: Palmitate treatment

May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing different fatty acid donors (N-linked stearoyl- (C18) or arachidoyl- (C20) ceramides) in a fumonisin B1-independent manner.

Boyer, J., Pascolo, S., Richard, G. F., Dujon, B. (1993). Sequence of a 7.8 kb segment on the left arm of yeast chromosome XI reveals four open reading frames, including the CAP1 gene, an intron-containing gene and a gene encoding a homolog to the mammalian UOG-1 gene. Yeast 9:279-287.8488728 ...

Purpose Recent research indicated undisputed contribution of connective tissues growth aspect (CTGF) in the development of several cancers including non-small cell lung cancer (NSCLC). on CTGF transcript and proteins amounts in NSCLC cells (A549 Calu-1). DNA methylation position from the regulatory area was examined by bisulfite sequencing. The influence of 5-dAzaC and TSA on NSCLC cells proliferation and viability was monitored with the trypan blue assay. Results We discovered significantly decreased degrees of CTGF mRNA and proteins (both occurred irrespective of gender in every histological subtypes of NSCLC. Furthermore we showed that 5-dAzaC and TSA could actually restore CTGF proteins and mRNA items in NSCLC cells. Zero methylation within regulatory area was detected Nevertheless. Both compounds reduced NSCLC cells proliferation significantly. Conclusions Decreased appearance of is normally a common feature in NSCLC; nonetheless it could be restored with the chromatin-modifying realtors ...

अलीबाबा 3 Dihydro 1h Inden 2 एमाइन दुनिया की अग्रणी निर्यात उत्पादों बाजार है, आपको उच्च गुणवत्ता पूर्ण 3 Dihydro 1h Inden 2 एमाइन की आपूर्ति जानकारी का चयन देख सकते हैं, आप पा सकते हैं इसके अलावा थोक ऑनलाइन 3 Dihydro 1h Inden 2 एमाइन बातचीत, नवीनतम 3 Dihydro 1h Inden 2 एमाइन मूल्य उद्धरण और विश्वास के साथ खरीद।

Sigma-Aldrich offers abstracts and full-text articles by [Franziska Peters, Susanne Vorhagen, Susanne Brodesser, Kristin Jakobshagen, Jens C Brüning, Carien M Niessen, Martin Krönke].

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Human LASS1 full-length ORF ( AAH84582.1, 1 a.a. - 239 a.a.) recombinant protein with GST-tag at N-terminal. (H00010715-P01) - Products - Abnova

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Equities Research Analysts updated eps estimates for Friday, December 1st: AeroCentury (NYSEAMERICAN:ACY) was downgraded by analysts at Zacks Investment Research from a hold rating to a sell rating. According to Zacks,

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TY - JOUR. T1 - Structural insights into lipid-dependent reversible dimerization of human GLTP. AU - Samygina, Valeria R.. AU - Ochoa-Lizarralde, Borja. AU - Popov, Alexander N.. AU - Cabo-Bilbao, Aintzane. AU - Goni-De-Cerio, Felipe. AU - Molotkovsky, Julian G.. AU - Patel, Dinshaw J.. AU - Brown, Rhoderick E.. AU - Malinina, Lucy. N1 - Copyright: Copyright 2013 Elsevier B.V., All rights reserved.. PY - 2013/4. Y1 - 2013/4. N2 - Human glycolipid transfer protein (hsGLTP) forms the prototypical GLTP fold and is characterized by a broad transfer selectivity for glycosphingolipids (GSLs). The GLTP mutation D48V near the portal entrance of the glycolipid binding site has recently been shown to enhance selectivity for sulfatides (SFs) containing a long acyl chain. Here, nine novel crystal structures of hsGLTP and the SF-selective mutant complexed with short-acyl-chain monoSF and diSF in different crystal forms are reported in order to elucidate the potential functional roles of lipid-mediated ...

CERS5 - CERS5 (Myc-DDK-tagged)-Human LAG1 homolog, ceramide synthase 5 (LASS5) available for purchase from OriGene - Your Gene Company.

The CERS (or LASS) homeobox gene class is highly unusual and encodes proteins that seem to be transmembrane in nature (Mizutani and Kihara 2005; Pewzner-Jung et al. 2006). The function of the homeodomain in these proteins is unknown. There are six CERS (ceramide synthase) genes in the human genome, but only five of these include a homeobox sequence and are therefore included in the CERS homeobox gene class (Holland et al. 2007). Amphioxus has a single CERS homeobox gene ...

The CERS (or LASS) homeobox gene class is highly unusual and encodes proteins that seem to be transmembrane in nature (Mizutani and Kihara 2005; Pewzner-Jung et al. 2006). The function of the homeodomain in these proteins is unknown. There are six CERS (ceramide synthase) genes in the human genome, but only five of these include a homeobox sequence and are therefore included in the CERS homeobox gene class (Holland et al. 2007). Amphioxus has a single CERS homeobox gene ...

Sigma-Aldrich offers abstracts and full-text articles by [Philipp Ebel, Silke Imgrund, Katharina Vom Dorp, Kristina Hofmann, Helena Maier, Helena Drake, Joachim Degen, Peter Dörmann, Matthias Eckhardt, Thomas Franz, Klaus Willecke].

Feldmann, H., Aigle, M., Aljinovic, G., Andre, B., Baclet, M. C., Barthe, C., Baur, A., Becam, A. M., Biteau, N., Boles, E., Brandt, T., Brendel, M., Bruckner, M., Bussereau, F., Christiansen, C., Contreras, R., Crouzet, M., Cziepluch, C., Demolis, N., Delaveau, T., Doignon, F., Domdey, H., Dusterhus, S., Dubois, E., Dujon, B., El Bakkoury, M., Entian, K. D., Feurmann, M., Fiers, W., Fobo, G. M., Fritz, C., Gassenhuber, H., Glandsdorff, N., Goffeau, A., Grivell, L. A., de Haan, M., Hein, C., Herbert, C. J., Hollenberg, C. P., Holmstrom, K., Jacq, C., Jacquet, M., Jauniaux, J. C., Jonniaux, J. L., Kallesoe, T., Kiesau, P., Kirchrath, L., Kotter, P., Korol, S., Liebl, S., Logghe, M., Lohan, A. J., Louis, E. J., Li, Z. Y., Maat, M. J., Mallet, L., Mannhaupt, G., Messenguy, F., Miosga, T., Molemans, F., Muller, S., Nasr, F., Obermaier, B., Perea, J., Pierard, A., Piravandi, E., Pohl, F. M., Pohl, T. M., Potier, S., Proft, M., Purnelle, B., Ramezani Rad, M., Rieger, M., Rose, M., ...

Expression of CERS5 (FLJ25304, LASS5, MGC45411, Trh4) in cerebellum tissue. Antibody staining with HPA026589 in immunohistochemistry.

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Title Change Cell Death Soc 12/9 meeting 1. Dr. Joseph Doyle, Rockefeller University Characterization of new genes in the regressing rat prostate 2. Dr. Wen-Chieh Liao, Radiation Oncology, Memorial Sloan-Kettering AT inhibits DNA damage-induced apoptosis via ceramide synthase ...

Stock Analysts downgrades for Wednesday, January 3rd: Ballard Power Systems (NASDAQ:BLDP) (TSE:BLD) was downgraded by analysts at Zacks Investment Research from a hold rating to a sell rating. According to Zacks,

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Alzheimers Disease Infectious As you probably know, Alzheimers disease is no laughing matter. Its deadly, incurable and spreading like wildfire. As we discuss in this article, there are several contributing factors to the epidemic. One cause of Alzheimers disease is … Continue reading →. ...

Last month, a committee of the British Parliament recommended allowing couples who conceive through in vitro fertilization to screen their embryos for ...

Tacrolimus 8-Propyl Analog (USP) ;. Dihydro Tacrolimus ;. Dihydro FK-506 ;. Tsukubamycin B ;. CAS # 104987-30-6 ;. C44H71NO12 ;. MW: 806.03 ;. ...

This is the story of 4 scientists but especially 4 friends who find that life is beautiful and short at the same time. They are strongly convinced that aging is not a fatality and they are determined to be a part of this revolution. In order to change the world they have a team, and they will share reliable and accessible scientific information with everyone ...

Genetic information processingProtein fateProtein modification and repairapolipoprotein N-acyltransferase (TIGR00546; EC 2.3.1.-; HMM-score: 15.1) ...

What I object to is these people using a show to clear their names. And worst of all, a gullible public will accept their television image. Monica was smart. For the first half she played the nice homely lass; after her eviction and re-entry as a wild card, she had transformed into a glamorous (as glamorous as she could manage) woman. You need to be dumb not to realise which one was real. Neither. She is just a smart cookie who wants to get back into films; now her old lover (he says they had got married) is not there to help her like he did earlier. She gave a sob story - which may be partially true - about people not renting out a place to her. That is what happens to many such young women in the city even if they dont have a gangster background. ...

After holding off for nearly two years, Im posting this because too many people have asked for it. The lasses should read it, too, as the same principles can be applied to bodyfat loss. I weighed 152 lbs.

After holding off for nearly two years, Im posting this because too many people have asked for it. The lasses should read it, too, as the same principles can be applied to bodyfat loss. I weighed 152 lbs.

The Interbreed/Breed Champion from the Royal Counties Show was Angus Neishs cow Rodmead Bonny Lass with her Nov 2018 born bull calf Rodmead Ben Lomond.

South Korea is a national nation exemplified by a combined mix of upscale new technology and historic mysticism. supplementary material The web version of the content (doi:10.1007/s12192-010-0229-3) contains supplementary materials which is open to authorized users. South Korea is a country wide nation exemplified by a combined mix of upscale new technology and historic mysticism. The busy roads of Seoul busyness like any huge active metropolis the citys inhabitants radiate an intrinsic feeling of peace making a classic atmosphere. The mix of rising technology and deep respect for the Korean lifestyle and traditions makes this nation a distinctive environment where to organize an effective scientific get together. Cell Tension Culture International (CSSI) in its goal to combination the ethnic frontiers of research and propagate analysis GSK1292263 on the strain response partnered using the recently made Korean Cell Tension Society (KCSS) to carry the 8th International Workshop over the ...

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Results presented in this study show that treatment with the combination of gemcitabine/doxorubicin improves the regulation of growth of HNSCC cells both in situ and in animal models, suggesting that this combination might offer an alternative treatment strategy against these cancers. Importantly, treatment of SCID mice bearing UM-SCC-22A xenografts with gemcitabine/doxorubicin combination significantly inhibited HNSCC tumor growth, which was concomitant with a significant increase in C18-ceramide levels. In addition, further analysis of a possible role for C18-ceramide, a product of LASS1 activity, in drug-induced cell death in situ, showed that treatment with gemcitabine/doxorubicin resulted in a significant increase in LASS1 expression and endogenous enzymatic activity of LASS1 for the generation of C18-ceramide in these cells. Mechanistically, the data obtained using molecular approaches either to partially inhibit or induce LASS1 expression in these cells revealed an important role of ...

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Dr Moritz Lassé has been awarded a Heart Foundation research grant to investigate ways to pick up kidney damage after heart failure.

The Shc-like PID specifically binds to the Asn-Pro-Xaa-Tyr(P) motif found in many tyrosine-phosphorylated proteins including growth factor receptors. On the other hand the Dab-like PID domain binds to non-phosphorylated tyrosine residue or even a phenylalanine at the same position [ (PUBMED:7534213) ]. Most of the ligands for Shc-like PID domains are RTK or cytokine, whereas phosphotyrosine independent Dab-like PID domains seems to mediate other types of signaling pathways, like endocytosis/processing or exocytosis. This domain binds both peptides and headgroups of phosphatidylinositides, utilising two distinct binding motifs to mediate spatial organisation and localisation within cells [ (PUBMED:15567406) (PUBMED:7534213) (PUBMED:7527937) (PUBMED:7798194) ]. The 3D structure of PID domain has been solved [ (PUBMED:12737822) ]. It shares a folding pattern, commonly referred to as the PH-domain superfold. The core superfold consists of seven antiparallel beta strands forming two orthogonal ...

The Shc-like PID specifically binds to the Asn-Pro-Xaa-Tyr(P) motif found in many tyrosine-phosphorylated proteins including growth factor receptors. On the other hand the Dab-like PID domain binds to non-phosphorylated tyrosine residue or even a phenylalanine at the same position [ (PUBMED:7534213) ]. Most of the ligands for Shc-like PID domains are RTK or cytokine, whereas phosphotyrosine independent Dab-like PID domains seems to mediate other types of signaling pathways, like endocytosis/processing or exocytosis. This domain binds both peptides and headgroups of phosphatidylinositides, utilising two distinct binding motifs to mediate spatial organisation and localisation within cells [ (PUBMED:15567406) (PUBMED:7534213) (PUBMED:7527937) (PUBMED:7798194) ]. The 3D structure of PID domain has been solved [ (PUBMED:12737822) ]. It shares a folding pattern, commonly referred to as the PH-domain superfold. The core superfold consists of seven antiparallel beta strands forming two orthogonal ...

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Bochum war unser Kern des mittleren Ruhrgebietes Unter anderem neben Duisburg, spachteln, Dortmund & Hagen eines irgendeiner funf Zentren des Ruhrgebiets. Bochum zahlt drauf den 20 gro?ten Stadten Deutschlands.. An den neun Hochschulen Bei Bochum Studium qua 40.000 Studentinnen & Studenten. Im zuge dessen sei Bochum folgende der gro?ten Universitatsstadte Deutschlands. UniverCity Bochum nennt sich dasjenige Community von seihen Bochumer Hochschulen anhand DM Perspektive die Bekanntheit vorwarts voranzutreiben.. Aber Nichtens alleinig Welche Universitaten Ferner Hochschulen werden gro?e Geschaftsinhaber, eres existireren beilaufig mehr als 15.000 Ansinnen. Die Stadtverwaltung weiters die Bundesknappschaft-Bahn-See angemessen sein zugeknallt den gro?ten Arbeitgebern As part of Bochum. Universitaten, Kliniken oder gro?en Streben mit sich bringen dieserfalls, weil jede Menge Alumnus und Entrepreneur As part of Bochum leben und schuften.. War Pass away Partnervermittlung Bochum erfolgreich, ...

The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...

The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...

Cerus Corporation (NASDAQ:CERS) announced today that it has entered into a $40 million amended growth capital credit facility with Oxford Finance LLC,

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al Aula consiliare - P.zza roma n.7 (Marrubiu, Oristano) Un Sandro Pertini versatile e citazionista, seduto su una nuvola in un dialogo serrato con Andrea Pazienza: è lespediente pop per ripercorrere la vita e limpegno politico di un indimenticabile uomo, politico, partigiano. Anche da lassù, inquieto, lex Presidente della Repubblica vuole muoversi alla salvezza dellItalia… La coppia Elettra Stamboulis e Gianluca Costantini, dopo Cena con Gramsci e Arrivederci, Berlinguer, si cimenta in un racconto a fumetti su Pertini: lapproccio è, come sempre, innovativo e sorprendente sia nei testi che negli stili grafici in continua mutazione. Come i personaggi interpretati, nello scorrere delle pagine, dai due protagonisti. Paz? Ti voglio narrare labicì di come si diventa socialista. E soprattutto, come lo si resta. ...

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