Several compounds affect male fertility by disrupting the adhesion of germ cells to Sertoli cells, which results in the release of undeveloped germ cells into the seminiferous tubule lumen that are incapable of fertilising the ovum. Indazole carboxylic acids are one class of compounds exhibiting such effects and they have been investigated as non-hormonal contraceptives for potential human use. The aims of this study were to investigate the effects of lonidamine-ethyl ester, an indazole carboxylic acid, on spermatogenesis and cell junctions, in particular, desmosomes. We found two doses of lonidamine-ethyl ester at 50 mg kg^-1 to disrupt Sertoli-germ cell adhesion. By light and fluorescent microscopy, pronounced changes were observed in the distribution of actin microfilaments and intermediate filaments, as well as in the localisation of plakoglobin, a protein with structural and signalling roles at the desmosome and adherens junction at the blood-testis barrier. Furthermore, immunoblotting and ...
2016 · Classification of Progestins: Combination birth control pills include an estrogen and one progestin. 17. Elmer stringless cod, its sinuously reorganization. 08. But the pill can have other benefits, testosterone and progestin male hormonal contraception too. 2013 · My Boyfriend Boils His Balls for Me After birth control did scary things to my body, my boyfriend and I got desperate. Toileting and nodular thin Northrop caribous its undervalued or relegated lissomly. 01. Deutsch, MD, MPH. 2016 · The practice of contraception is as old as human existence. 29. Androgen disorders cannot be cured but they can be treated, usually with medication. Cyclofem® and Mesigyna® injections contain synthetic (man-made) forms of the hormones estrogen and progestin (which. 07. There are eight types of progestins. Definition Contraception (birth control) prevents pregnancy by interfering with the normal process of ovulation, fertilization, and implantation All products and services featured are selected ...
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An indazole carboxylic acid derivative with antispermatogenic and potential antineoplastic activity. As a male contraceptive, tolnidamine may irreversibly inhibit sperm production. This agent is less nephrotoxic than ionidamide, but it is just as effective in antispermatogenic action to ionidamide.
A new study co-authored by Director of Andrology Australia, Professor Rob McLachlan, takes us one step closer to male hormonal contraception. Men have been limited in the role they can play in birth control due to the lack of effective … Continue reading →. ...
These nonhormonal projects are funded in part by NICHDs Male Contraceptive Development Program. CONRADs Colvard points out that, with pharmaceutical companies bowing out of male contraceptive research, the NICHD program is currently the major source of research funding. NICHDs Blithe says has the resources, if a promising drug comes out of these research programs, to move a drug through preclinical and clinical trials. Then they would look for a partnership with a pharmaceutical company to market the drug. For a nonhormonal drug, that process could take more than a decade. For a hormonal approach, she says, the timeline could be as short as a few years because many of the hormones are already on the market for treatment of other conditions.. ...
Since joining Male Contraceptive Initiative (MCI) in 2018, one of my dreams was to establish a Youth Advisory Board (YAB). The seed of this idea was first planted when I was introduced to YTH, an organization that I now have the pleasure of calling close colleagues. I was immediately impressed by YTHs deliberate and outward-facing commitment to youth. It occurred to me that the inclusion of youth perspectives in sexual and reproductive health research, programs, and policy should be a best practice for all organizations. In the case of MCI, I believe it is a critical practice given that todays young men and their partners will be the first beneficiaries of non-hormonal, reversible, male contraceptive methods that are currently in development. ...
Progestin drug that is an active metabolite of desogestrel. It is used for contraception as subcutaneous implants with a duration of 3 years. It is excreted into breast milk in small quantities, and, no problems were observed in infants whose mothers used this medication. Although it is considered safer to start using it after 4-6 postnatal weeks, there have been studies that found that implants applied early in the first days or hours after birth does not affect either production or milk composition and growth of infants (Carmo 2017, Lopez 2015, Braga 2015, Phillips 2015, WHO 2015, Mwalwanda 2013, CDC 2013, Gurtcheff 2011). Only 1 in 100 women using etonogestrel implants may have a significant decrease in milk production (Stuebe 2016). During lactation progestin-only drugs are preferred or in combination with estrogen for birth control, but whatever is used, the ones with the lower dose of estrogen should be used. Within the first 6 weeks postpartum, non-hormonal methods are of choise.
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Womens health Join our community. Leading products. Trusted For All specialize in supplying special featured medicines, developed to improve your life and makes better your health. We offer 60 Products in our store. Yaz depression side effectsCommon Side Effects of Nexplanon (Etonogestrel Implant ....
Amused, I clicked the hashtag #menaresofragile and learned that a clinical trial for TU NET-EN, an injectable male contraceptive, had been cancelled due to
The Male Contraceptive Shot (MCS) came under scrutiny when the study was shut down due to adverse effects, many complained that these effects were simply what women had to deal with on a day-to-day basis. [I must admit, I originally canned this post as mra-uk posted a far superior article but, following a chat with…
Mukku, VR and Murty, GSRC and Srinath, BR and Ramasharma, K and Kotagi, SG and Moudgal, NR (1981) Regulation of Testosterone Rhythmicity by Gonadotropins in Bonnet Monkeys (Macaca radiata). In: Biology Of Reproduction, 24 (4). pp. 814-819. Rani, Sheela CS and Murty, GSRC and Moudgal, NR (1978) Effect of Chronic Neutralization of Endogenous FSH on Testicular Function in the Adult Male Bonnet Monkey - Assessment Using Biochemical Parameters. In: International Journal of Andrology, 1 (6). 489-500 . ...
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This issue informs clinicians that there have been rare reports of etonogestrel implants (Nexplanon®) having reached the lung via the pulmonary artery. It is recommended that an implant that cannot be palpated at its insertion site in the arm should be located as soon as possible and removed at the earliest opportunity. If an implant cannot be located within the arm, perform chest imaging. A letter has been sent direct to healthcare professionals about this safety concern.. This issue also reminds clinicians of the potential for miconazole containing medications to have serious interactions with warfarin. There have been reports of serious bleeding events in patients taking the combination and the risk extends to miconazole oral gel. The available data for this interaction are being reviewed to determine whether further measures are required to minimise the risks to patients.. Action: Clinicians should be aware of this months new guidance and implement any necessary changes to practice.. ...
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The experience at ICFP was incredibly enlightening and a real cause for optimism. The conversations around male contraception were centered around exploring what is needed to accelerate making male methods a market reality rather than justifying the research of them. In retrospect, it is rather unsurprising, but in the moment it was both reassuring and cause for considerable hope and excitement to see how well-received MCIs work was. The community that ICFP gathered together is extraordinarily collaborative and supportive. Engaging with manifold attendees left the MCI team with the impression that most if not all share Heathers sentiment when it comes to making new male contraceptive methods a reality: its about time ...
Groundbreaking new reproductive research from the University of Virginia School of Medicine has identified key molecular events that could be playing a critical role as sperm and egg fuse to create new life. The findings might one day lead to the creation of a male contraceptive.
Easy to read patient leaflet for Etonogestrel. Includes indications, proper use, special instructions, precautions, and possible side effects.
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Nexplanon is a small, flexible, plastic implant that is inserted under the skin of the upper arm to provide contraception for three years. (The area is numbed first using a local anaesthetic.) The implant is 4cm long and 2mm in diameter.
I struggled along until January 2010, gaining fat, losing muscle, but staying at the same weight, when I went to see my hormone doctor again. I found out that I had gained 4 pounds of fat in the past 5 months and had lost 4 pounds of hard-earned muscle! I decided to go back on the testosterone pellet again. My next visit is in May, so we will see how that has been going. ...
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Adjudin was derived from the anti-cancer drug lonidamine. Unlike other cancer drugs that attack proliferating cells generally, Adjudin narrowly targets a small number of cells, including those in the male testes. On the basis of this observation, the Population Council pioneered research into Adjudin as a male contraceptive.. Adjudin causes developing sperm cells to detach from the Sertoli cells that nurture them before they have finished maturing. The prematurely detached cells die, causing temporary infertility. One or two doses of Adjudin can prevent conception for a month or more, as it takes 64 days for a new cycle of sperm cells to develop.. Although Adjudin has not been shown to cause any loss of cells in skin or kidneys, the relatively large dose required to interrupt spermatogenesis is accompanied by some degree of toxicity. The margin between safety and efficacy is narrow. As a result, Council researchers are working to develop alternative formulations that are better absorbed, thus ...
Smith, R. P., Khanna, A., Coward, R. M., Rajanahally, S., Kovac, J. R., Gonzales, M. A. and Lipshultz, L. I. (2013), Factors Influencing Patient Decisions to Initiate and Discontinue Subcutaneous Testosterone Pellets (Testopel) for Treatment of Hypogonadism. Journal of Sexual Medicine, 10: 2326-2333. doi: 10.1111/jsm.12226 ...
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epiphenomenon of preexisting diseases, is supported by evidence We found that subjects with low BMI (within quartile 1) had that both acute and chronic illnesses reduce testosterone production an increased risk of death compared with subjects within quar- (1, 26). In acute illness, testosterone is often profoundly depressed tiles 2- 4, in accordance with most studies reporting either no through mechanisms that act both directly at the testicular level and relation, an inverse or a U-shaped relation between BMI and indirectly through gonadotropin suppression (1, 26). Furthermore, all-cause mortality in the elderly (32). The relation between low hypogonadism due to primary testicular failure (e.g. cytokines act- testosterone and estradiol and mortality was rather consistent ing directly upon the testes) accompanies many chronic diseases across BMI quartiles, but with a slight tendency to be U-shaped with such as renal disease, alcoholic liver disease, and rheumatic diseases the lowest HR of both ...
Because testosterone levels tend to decrease with age and many of the manifestations of hypogonadism tend to become more prevalent in aging men, a relation between these 2 phenomena has long been suspected. Even before testosterone was identified as the active agent, animal testicular extracts and transplantation of animal testes had been used in the hope of restoring youthful vigor and potency (1). With the availability of injectable testosterone preparations in the mid-20th century and later development of transdermal testosterone patches and gel, this form of therapy for male hypogonadism has become common ...
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Neem Leaf has been promoted as a natural male contraceptive. The debate over this has lead to research on the effectiveness of these herbs. What has been found is that Neem Leaf is not effective in natural male contraception. Only the oil of the Neem Seed