Fingerprint Dive into the research topics of Insulin‐like growth factor I/somatomedin‐C (IGF‐I/SM‐C) and glucocorticoids synergistically regulate mitosis in competent human fibroblasts. Together they form a unique fingerprint. ...

TY - JOUR. T1 - Comparative effects of somatomedin C and insulin on the metabolism and growth of cultured human fibroblasts. AU - Conover, Cheryl A.. AU - Hintz, Raymond L.. AU - Rosenfeld, Ron G.. PY - 1985/1. Y1 - 1985/1. N2 - At concentrations of 25 ng/ml in serum‐free medium, somatomedin C (SM‐C) and insulin stimulated 3H‐thymidine incorporation in adult human fibroblasts 4‐ and 1.5‐fold, respectively. The presence of 0.25% human hypopituitary serum (HHS), which by itself had little effect, enhanced the mitogenicity of both SM‐C and insulin. Furthermore, 10−7 M dexamethasone dramatically potentiated SM‐C stimulation (70‐fold) and insulin stimulation (28‐fold) of 3H‐thymidine incorporation. With dexamethasone and 0.25% HHS, significant stimulation of DNA synthesis was seen at 2.5 ng/ml for both SM‐C and insulin. The effects of SM‐C and insulin on 3H‐thymidine incorporation were additive. These 3H‐thymidine incorporation results were clearly supported by cell ...

0207] There are groups of genes present only in UCMC. These genes are related to the following: Normal Physiological Processes (Insulin-like growth factor 1 (somatomedin C); Insulin-like 4 (placenta); Relaxin 1; Plasminogen; Insulin-like growth factor 1 (somatomedin C); Insulin-like 5; Insulin-like growth factor 1 (somatomedin C); Insulin-like growth factor 2 (somatomedin A), Homeostasis (Radial spokehead-like 1; Hemochromatosis; Chemokine (C-C motif) ligand 5; Interleukin 31 receptor A; Chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1); Nuclear receptor subfamily 3, group C, member 2; Hemochromatosis; Chemokine (C-C motif) ligand 23; Chemokine (C-C motif) ligand 23; Ferritin mitochondrial; Peroxisome proliferative activated receptor, gamma, coactivator 1, alpha; Surfactant, pulmonary-associated protein D; Chemokine (C-C motif) ligand 11; Chemokine (C-C motif) ligand 3; Egl nine homolog 2 (C. elegans); Peroxisome proliferative activated receptor, gamma, coactivator 1, beta; ...

Loss of muscle bulk happens early in the course of CHF (15)and the development of cachexia is an adverse prognostic feature (16). The origin of the weight loss is not clear, but recent studies have drawn attention to the potential importance of neurohormonal and immune activation. Tumor necrosis factor is elevated in CHF (5,6); there is an increase in the ratio between circulating levels of catabolic and anabolic steroids (3), and an insulin-resistant state develops (17,18). The resting metabolic rate of patients with heart failure is increased (19)and resting leg oxygen consumption has been shown to be increased (8).. Growth hormone is secreted by the anterior pituitary, and mediates its major metabolic effects through activation of somatomedins, predominantly IGF-I (20,21). Levels of GH can be greatly elevated in untreated heart failure (9)and we have found elevated levels in patients with cardiac cachexia (4). Paradoxically, perhaps, there is some evidence for a beneficial effect in patients ...

Theres finally a study examining the effects of Leangains-style intermittent fasting. We have the results and a study breakdown for you here.. Overview of the test for insulin, used to help evaluate insulin production, diagnose an insulinoma, to help determine the cause of hypoglycemia, and to help identify.. Search for articles by this author Affiliations. GOFARR Laboratory for Organ Regenerative Research and Cell Therapeutics, Childrens Hospital Los Angeles, Division.. Are you ready for the cold dark days that come with Daylight Saving Time? Prepare for winter skin before turning your.. Insulin-like growth factor 1 (IGF-1), also called somatomedin C, is a protein that in humans is encoded by the IGF1 gene. IGF-1 has also been referred to as a.. Fasting requires discipline, but if done the right way, dieters can lose weight, boost their brain health, and lengthen their lives. Researchers from the University.. Insulin-like growth factor 1 (IGF-1), also called somatomedin C, is a protein that ...

Fetal growth is a complex process involving multiple environmental and genetic factors. Fetal growth restriction is associated with morbidity among small for gestational age (SGA) neonates as well as in children and adults who are former SGA infants. Over the last decade it has been recognized that …

IGF-1 is the precise test for human growth hormone activity. It is synthesized in the liver upon stimulation of the pituitary human growth hormone (HGH).

IGF-1 Somatomedin C growth factor recombinant protein protein animal health animal model veterinary western blot cell culture ELISA standard

In dieser Gruppe werden Erkrankungen zusammengefasst die auf einer Gestörten Wachstumshormonwirkung beruhen. Dabei können Störungen auf den verschiedensten Ebenen der Wachstumshormon-Signalkaskade liegen. Vom Releasing Hormon über das Wachstumshormon bis hin zum Somatomedin C (IGF1) genannten Zytokin. In jedem dieser Signalschritte kann wiederum sowohl das Hormon als auch der Rezeptor betroffen sein.. ...

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Two types of receptors for insulin-like growth factors (IGFs) were characterized in glioma cell lines established from different human brain tumors of glial origin (astrocytoma grades III and IV) by competitive binding assay, affinity labeling, and protein phosphorylation. Type I IGF receptor is a heterodimer composed of α-subunits (Mr 130,000), which bind IGF I and II with equal affinity, and of β-subunits (Mr 98,000), which show tyrosine kinase activity and autophosphorylation stimulated by IGF I and II with equal potency. The type II IGF binding site is a monomer (Mr 250,000) which binds IGF II with 10 times higher affinity than IGF I. The cellular concentration of type II IGF binding site is about 2- to 5-fold higher than the amount of type I IGF receptor. The characteristics of the two types of IGF receptors in human glioma cell lines are similar to those described recently in fetal rat astrocytes. In contrast the type I IGF receptor in glioma cells is different from that studied ...

Background: The maternal insulin-like growth factor (IGF) system is considered to be involved in fetal growth regulation. However, available data linking this system to fetal growth are contradictory and incomplete. Aims: To measure components of the IGF system before, during and after pregnancy in healthy women and to relate these results, and their changes during pregnancy, to fetal weight (gestational week 31) and birth weight. Methods: Serum concentrations of IGF-I, IGF-II, IGF-binding protein (IGFBP)-1, IGFBP-3 and IGFBP-3 protease activity were assessed in 23 women before conception, at weeks 8, 14, 20, 32 and 35 of pregnancy and 2 weeks postpartum. The data were analyzed using simple and multiple linear regression. Results: One third of the variability in fetal weight was explained by IGF-I in combination with IGFBP-3 protease activity, both assessed at gestational week 32 (p = 0.013). Birth weight was negatively correlated (r = -0.43 to -0.59) with IGFBP-1 at gestational week 20 (p = 0

Despite improvements in therapy, the prognosis for advanced breast cancer is poor and a search for new treatment targets and key regulators of tumour growth is warranted. Extensive data are available on the importance of the insulin-like growth factor (IGF) system in growth regulation of breast canc …

胰岛素样生长因子1（英语：Insulin-like growth factor 1，IGF-1）也被称为生长调节素C（somatomedin C），是一个由人类基因 IGF1 编码的蛋白质[3][4]。在1970年代，IGF-1也曾经被称为酸硫化（英语：sulfation）因子[5]，並認為其作用为不受抑制的胰岛样活力（nonsuppressible insulin-like activity，NSILA）。 IGF-1是一个在三级结构上与胰岛素类似的激素，在儿童成长发育中有重要作用，并持续在成人的合成代谢中起作用。一种人工合成的IGF-1类似物，美卡舍明（英语：mecasermin），用于治疗发育停滞[6]。 IGF-1蛋白由一个肽链构成，包括70个氨基酸残基和三个分子内二硫键，分子量为7,649道尔顿[7]。 ...

0026] Literature of interest includes: U.S. Pat. No. 5,824,642; Salmon WD Jr. et al., 1957, J Lab Olin Med, 49:825-36; Liu, J-L and LeRoith, D, 1999, Endocrinology 140:5178-84; Lupu, F et al., 2001, Dev Biol 229:141-62; Zhou, Y et al., 1997, Proc Natl Acad Sci USA 94:13215-20; and Juul, 2003, GH and IGF Research 13: 113-170. Van Wyk J J. The Somatomedins: biological actions and physiological control mechanisms in Hormonal Proteins and Peptides, ed C H Li, 12:81-175, Orlando, Fla.: Academic Press; Clemmons D R et al., 1984, Clin Endocrinol Metab 13:113-43; Clemmons D R et al., 1979, N Engl J Med 301:1138-42; Clemmons D R et al., 1986, Olin Endocrinol Metal 15:629-51; Liu, J-L and LeRoith, D, 1999, Endocrinology 140:5178-84; Lupu, F et al., 2001, Dev Biol 229:141-62; Zhou, Y et al., 1997, Proc Natl Acad Sci USA 94:13215-20; U.S. Pat. No. 6,358,925; Ammann, P., R. Rizzoli, et al. (1996). Bone density and shape as determinants of bone strength in IGF-I and/or pamidronate-treated ovariectomized ...

Normal tissue growth involves a complex interaction of cell proliferation, hypertrophy, migration, differentiation and senescence which proceeds within strict temporal and anatomical constraints. While classical endocrine hormones such as growth hormone and thyroxine can influence the overall rate of growth and maturation they do not contribute to the fundamental intercellular signalling within tissues that underlies these processes. This appears to be the primary role of peptide growth factors. During the rapid development of the embryo and fetus peptide growth factors are associated with tissue induction, the clonal growth of stem-cell populations, and the appearance of differentiated function in the presumptive organs. In post-natal life the actions of growth factors are less obvious although notable exceptions demonstrate that the same biological pathways exist; the best studied examples are the role of somatomedins during longitudinal skeletal growth and the coordinated actions of several growth

Caloric restriction (CR) inhibits tumorigenesis in rodents. To understand the basis for this effect the binding of insulin, insulin-like growth factor I/somatomedin C (IGF-I/Sm-C), insulin-like growth factor II/multiplication stimulating activity (IGF-II/MSA), and epidermal growth factor were examined to membrane preparations of 7,12-dimethylbenz(a)anthracene-induced mammary adenocarcinomas and several normal tissues from female Sprague-Dawley rats. Animals were fed ad libitum (AL) or 25% and 40% calorically restricted diets. Large, palpable (LP) and small, ≤ 100 mg, nonpalpable (SNP) tumors were evaluated. Growth factor binding to tumors was differentially affected by CR. IGF-I/Sm-C binding was comparable for AL-LP, AL-SNP, and 25% CR-LP tumors, but elevated in 25% CR-SNP tumors. Scatchard analysis revealed high and low affinity IGF-I/Sm-C binding sites, with AL-SNP and 25% CR-SNP tumors exhibiting similar levels of high affinity sites and at a greater concentration than AL-LP and 25% CR-LP ...

Insulin-like Growth Factor II (IGF-II) analogues in which at least one of R37 and R38 is replaced with another amino add residue, the most preferred being IGF-II R37Q R38Q, can readily be produced in E. coli, unlike natural IGF-II, which is cleaved on secretion. The analogues retain activity on the type I and type II IGF receptors but have lower affinity for the insulin receptor; they are therefore more specific in their action.

Rotwein P, et al. Genetic analysis of the hypervariable region flanking the human insulin gene. Am. J. Hum. Genet. 39: 291-299, 1986. PubMed: 2876625 Rotwein P, et al. Organization and sequence of the human insulin-like growth factor I gene. Alternative RNA processing produces two insulin-like growth factor I precursor peptides. J. Biol. Chem. 261: 4828-4832, 1986. PubMed: 2937782 ...

Objective:To determine whether insulinlike growth factor-I (IGF-I) and hepatocyte growth factor (HGF) cooperate to induce migration and invasion of human colorectal carcinoma (CRC) cells and whether the effects of IGF-I and/or HGF are mediated through activation of the urokinase plasminogen activato

Insulin-like growth factor 1 (IGF-1), also called somatomedin C, is a protein that in humans is encoded by the IGF1 gene.IGF-1 has also been referred to as a sulfation factor and its effects were termed nonsuppressible insulin-like activity (NSILA) in the 1970s. IGF-1 is a hormone similar in molecular structure to insulin. It plays an important role in childhood growth and continues to have anabolic effects in adults. A synthetic analog of IGF-1, mecasermin, is used for the treatment of growth failure. IGF-1 consists of 70 amino acids in a single chain with three intramolecular disulfide bridges. IGF-1 has a molecular weight of 7,649 Daltons ...

Studies have been conducted on fibromyalgia patients that have monitored their brain, hormonal, and metabolic activity. In these studies, the patients monitored activity have shown a rather large number of abnormalities. When brain scans of patients diagnosed with fibromyalgia the tests revealed that the patients had reduced blood flow to specific regions of their brains.. The specific regions of the brain were those that were in control of pain sensation to the body. The brain system known as the hypothalamus-pituitary-adrenal gland axis, a system that controls some very important functions, including depression, growth, stress response, and sleep, is particularly interesting to researchers of fibromyalgia.. A research target that has seen lots of attention lately is the somatomedin C hormone, also known as the insulin-like growth factor in laymans terms. This hormone is produced by the pituitary gland in the human brain while the body is in deep sleep. Its primary responsibility is to ...

Somatomedin definition is - any of several endogenous peptides produced especially in the liver that are dependent on and probably mediate growth hormone activity (as in sulfate uptake by epiphyseal cartilage).

IGF-1 or somatomedin C, is a growth factor, synthesised primarily by the liver under the influence of GH, of which it is the principal mediator. 95 % of IGF-1 circulates bound to binding proteins (the IGF-BPs), in particular IGF-BP3. Its assay constitutes an important diagnostic and prognostic tool in investigations of acromegaly or of a GH deficit.. ...

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TY - JOUR. T1 - Effect of Ethanol on Insulin‐Like Growth Factor‐II Release from Fetal Organs. AU - Mauceri, Helena J.. AU - Lee, Wei‐Hua ‐H. AU - Conway, Sonya. PY - 1994/2. Y1 - 1994/2. N2 - This study examines the effect of ethanol (ETOH) exposure and nutrient restriction on the release of insulin‐like growth factor (IGF)‐II from 18‐ and 20‐day explanted fetal organs. Fetuses were exposed to ETOH (E) in utero by feeding dams a 36% (calories derived from ETOH: 6.6% v/v) ETOH liquid diet. Control fetuses were offsprings of dams either pair‐fed (P) a control liquid diet or ad libitum (A) fed a standard pelleted lab chow. Brain, heart, kidney, liver, lung, muscle, and placenta of fetuses from the same litter were pooled and explanted, and IGF‐II concentration in explanted media was analyzed by radioimmunoassay. Maternal and fetal weights were determined during pregnancy and at sacrifice, respectively, to evaluate the influence of ETOH on growth. Both maternal and fetal weights ...

TY - JOUR. T1 - Insulin‐like Growth Factor 1, but Not Growth Hormone, Has In Vitro Proliferative Effects on Neonatal Foreskin Fibroblasts without Affecting 5‐α‐Reductase or Androgen Receptor Activity. AU - DYKSTRA, KENNETH D.. AU - PAYNE, A. MATTHEW. AU - ABDELRAHIM, MAGED. AU - FRANCIS, GARY L.. PY - 1993/1/1. Y1 - 1993/1/1. N2 - ABSTRACT: Clinical observation of patients with congenital growth hormone (GH) deficiency and Laron‐type dwarfism suggests that factors such as GH or insulin‐like growth factor 1 (IGF‐1) might, in addition to androgens, be needed for normal phallic growth. We speculated GH or IGF‐1 might have direct actions on genital tissues and performed the present study to evaluate the in vitro effects of GH and IGF‐1 on cultured neonatal foreskin fibroblasts. Cells derived from foreskins of normal newborns were studied between cell passages 6 and 15. Serum‐free media with and without 100 ng/ml GH, IGF‐1, or both were added 24 hours prior to and at the time of ...

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Insulin Like Growth Factor II (Somatomedin A or T3M 11 Derived Growth Factor or IGF2) - Pipeline Review, H2 2017 Size and Share Published in 2017-08-22 Available for US$ 3500 at Researchmoz.us

Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Rat Insulin Like Growth Factor Binding Protein 6 (IGFBP6) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species ...

Conduct problems (CP) and attention deficit hyperactivity disorder (ADHD) are often comorbid and have each been linked to unhealthy diet. Early‐life diet also associates with DNA methylation of the insulin‐like growth factor 2 gene (IGF2), involved in fetal and neural development. We investigated the degree to which prenatal high‐fat and ‐sugar diet might relate to ADHD symptoms via IGF2 DNA methylation for early‐onset persistent (EOP) versus low CP youth. Read the Commentary on this article at doi ...

LOC645468 (insulin like growth factor 2 mRNA binding protein 3 pseudogene), Authors: Dessen P. Published in: Atlas Genet Cytogenet Oncol Haematol.

Circulating total testosterone and insulin like growth factor 1 as determinants of haemoglobin level in men with chronic heart failure Conference Paper ...

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The insulin‐like growth factor (IGF)‐system includes insulin‐like growth factors I and II (IGF‐I and IGF‐II) along with the type I (IGF‐1R) and type II (IGF2R) cell‐surface receptors, the insulin receptor (IR) and circulating IGF‐binding proteins (IGFBPs) (Denley et al, 2005). The biological actions of the IGFs are mediated by IGF‐1R and IR, leading to cell growth, differentiation and survival. Their distribution and activity is controlled via high‐affinity association with IGFBPs, and the binding sites on IGFs for IGFBPs have been delineated in detail by structural studies (Headey et al, 2004; Carrick et al, 2005; Sitar et al, 2006). In mammals, the activity of IGF‐II (but not IGF‐I) is further moderated by IGF2R, which sequesters IGF‐II for internalization and degradation. IGF2R is classed as a growth inhibitor, with loss of function causing increased growth (Foulstone et al, 2005). In line with this, Igf2r is a putative tumour suppressor gene and mutations have been ...

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Title: Recombinant Human Insulin-Like Growth Factor-1: A New Cardiovascular Disease Treatment Option?. VOLUME: 6 ISSUE: 4. Author(s):E. Conti, M. B. Musumeci, G. Egidy Assenza, G. Quarta, C. Autore and M. Volpe. Affiliation:Cardiology, II Faculty of Medicine, University of Rome La Sapienza, Rome, Ospedale Sant Andrea, Italy.. Keywords:IGF-1, insulin, rhIGF-1, myocardial infarction, diabetes, outcome, flow metabolism coupling, endothelium. Abstract: The Insulin-like growth factor-1 (IGF-1) system is dynamic and complex, involving many binding proteins, binding-proteinrelated proteases, and receptors. It has emerged in time as a powerful defence to life processes of many cytotypes, tissues and systems. Mainly in body metabolism, diabetes and cardiovascular system, but also in brain and kidney, IGF-1 plays a key role in maintaining homeostasis, increasing progenitor cell potential, and improving physiologic performance both in rest and stress conditions. Its vasculoprotective and insulin ...

7.1. Insulin-like growth factors (IGF-I & IGF-II). Of the growth factors, those with the most potent effects on growing skeletal tissue are the IGFs, previously known as somatomedins. IGFs are synthesised in the liver and circulate bound to carrier proteins (Froesch et al., 1985). The major factors regulating IGF concentrations in serum are growth hormone, nutritional intake and thyroid hormones, the latter being necessary for growth hormone secretion. The traditional view was that growth hormone acted indirectly on the growth plate via IGF-I, a potent mitogen for growth plate chondrocytes. However, there is increasing evidence that growth hormone has direct effects on the growth plate (Tripper et al., 1989). (This close relationship between circulating IGFs and growth hormone will be discussed in more detail in the chapter covering the hormonal regulation of growth.). In addition to having effects on the growth plate chondrocytes, locally synthesised and circulating IGFs retained in bone matrix ...

J Clin Endocrinol Metab. 2000 Apr;85(4):1686-94.. Mauras N, OBrien KO, Welch S, Rini A, Helgeson K, Vieira NE, Yergey AL.. Division of Endocrinology, Nemours Childrens Clinic, Jacksonville, Florida 32207, USA. [email protected]. We examined the effects of recombinant human (rh) insulin-like growth factor I (IGF-I) vs. rhGH in a variety of metabolic paths in a group of eight severely GH-deficient young adults using an array of contemporary tools. Protein, glucose, and calcium metabolism were studied using stable labeled tracer infusions of L-[1-13C]leucine, [6,6-2H2]glucose, and 42Ca and 44Ca; substrate oxidation rates were assessed using indirect calorimetry; muscle strength was determined by isokinetic and isometric dynamometry of the anterior quadriceps, as well as growth factors, hormones, glucose, and lipid concentrations in plasma before and after 8 weeks of rhIGF-I (60 microg/kg, sc, twice daily), followed by 4 weeks of washout, then 8 weeks ofrhGH (12.5 microg/kg-day, sc); the ...

Purpose: We demonstrated that IGFBP-3 stimulates hematopoietic stem cells (HSC) to differentiate into endothelial cells, form capillaries, and stabilize the vasculature (Chang, et al, PNAS 2007). Local IGFBP- 3 production is increased by hypoxia and facilitates the homing of HSC to areas of injury. In the circulation, IGFBP-3 is bound to HDL. In this study, we investigated the signaling pathways responsible for the robust migratory effects of IGFBP-3.. Methods: The effects of IGFBP-3 on NO generation in human vascular precursors (CD 34+, CD14−), human lung microvascular endothelial cells, and human umbilical vein endothelial cells were examined using DAF-FM fluorescence. Western analysis was use for detection of eNOS and vasodilator-stimulated phosphoprotein (VASP), which redistributes to lamellipodia forming an active motor complex that supports motility and is phosphorylated in response to NO. Localization of VASP was performed by immunohistochemistry. SK-1 was assessed following IGFBP-3 ...

These reference sequences exist independently of genome builds. Explain. These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above. ...

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There are several limitations in this study. First, to reduce cost, we used a candidate gene approach and subjectively selected 25 SNPs from 7 IGF axis genes for study. The coverage and information of our SNP list highly depended on the data from the HapMap project. Furthermore, other types of genetic polymorphisms, such as copy number variants, 90 may be responsible for the underlying association with AMD risk. Therefore, false-negative findings are possible. On the other hand, because of the small sample size for geographic atrophy (Table 5), false-positive findings are also possible. In addition, we used Bonferronis correction for our hypothesis testing on the 25 SNPs. Furthermore, multiple tests were performed for each SNP. This may also increase the likelihood of false-positive findings. Although rs2872060 is implicated in AMD risk, no study has related it to major systemic diseases or mortality. However, polymorphisms in IGF axis genes are related to risk for some diseases and aging, and ...

Fibromyalgia (FM) and chronic fatigue syndrome (CFS) are similar conditions characterized by substantial fatigue, diffuse myalgias, sleep disturbances

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SEA050Ra, ELISA Kit for Insulin Like Growth Factor 1 (IGF1), 胰岛素样生长因子1(IGF1)检测试剂盒(酶联免疫吸附试验法), IGFI; IGF1A; IBP1; MGF; Somatomedin C; Mechano Growth Gactor | 仅供体外研究使用，不用于临床诊断！请索取进口关税税单及报关单！

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Ligand binding properties of five single amino acid substituted variants (V11A, D12A, Q15A, Q15E, and F16A) of human insulin-like growth factor I (IGF-I) were analyzed with respect to their binding affinities and binding kinetics to recombinant IGF binding protein 1 (IGFBP-1) and a soluble form of the IGF type I receptor (sIGF-I(R)), respectively. Side chains of the substituted residues are all predicted to be the most surface exposed in the alpha-helical portion of the B-region of the IGF-I molecule. The IGF-I variants were produced as fusion proteins to a IgG(Fc) binding protein domain, Z. Ligand binding kinetic rates were determined using BIAcore biosensor interaction analysis technology. All IGF-I variants showed altered binding affinities to both IGFBP- I and sIGF-I(R). Secondary structure content of the IGF-I variants was estimated using far-UV circular dichroism spectroscopy, followed by variable selection secondary structure calculations. The amount of calculated alpha-helicity is ...

OsrIGF-1 is expressed as fusion protein with HSA, which increases its solubility and lifetime. OsrIGF-1 presents a molecular weight about 74.5kD, and has a much higher stability compared to IGF-1.

Author(s): Adams, Gregory R | Abstract: Similar to bone, skeletal muscle responds and adapts to changes in loading state via mechanisms that appear to be intrinsic to the muscle. One of the mechanisms modulating skeletal muscle adaptation it thought to involve the autocrine and/or paracrine production of insulinlike growth factor-I. This brief review outlines components of the insulinlike growth factor-I system as it relates to skeletal muscle and provides the rationale for the theory that insulinlike growth factor-I is involved with muscle adaptation.

Objective To retrospectively validate the WINROP (weight, insulinlike growth factor I, neonatal, retinopathy of prematurity [ROP]) algorithm in a Brazilian population. WINROP aims to predict ROP and is based on longitudinal weight measurements from birth until postmenstrual age 36 weeks. WINROP has predicted 100% of severe ROP in 3 neonatal intensive care unit settings in the United States and Sweden.. Methods In children admitted to the neonatal intensive care unit at Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil, from April 2002 to October 2008, weight measurements had been recorded once a week for children screened for ROP, 366 of whom had a gestational age of 32 weeks or less. The participating children had a median gestational age of 30 weeks (range, 24-32 weeks) at birth and their median birth weight was 1215 g (range, 505-2000 g).. Results For 192 of 366 children (53%), no alarm or low-risk alarm after postmenstrual age 32 weeks occurred. Of these, 190 of 192 did not develop ...

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The interactions of insulin-like growth factors (IGFs) with the type I IGF receptor are modulated by a family of high-affinity IGF binding proteins (IGFBPs). One of these, IGFBP2, demonstrates a striking spatiotemporal relationship with IGF-I during cerebellar and retinal development. IGF-I mRNA is transiently expressed in large projection neurons--cerebellar Purkinje and retinal ganglion cells--while IGFBP2 mRNA is selectively expressed by contiguous neuroglia--Bergmann glia in the cerebellum and Muller cells and astrocytes of the nerve fiber layer in the retina. IGF-I and IGFBP2 gene expression is not only neuroanatomically coordinated but also temporally synchronized, peaking together during the postnatal maturation of these structures. This pattern of IGF system expression suggests that IGFBP2 is closely related to IGF-Is action in the developing nervous system.. ...

Complete information for IGFBP1 gene (Protein Coding), Insulin Like Growth Factor Binding Protein 1, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium

Complete information for IGFBP5 gene (Protein Coding), Insulin Like Growth Factor Binding Protein 5, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium

Benjamin Lester of Cosmos Online reports:Much of the amazing variation in size of different breeds of domestic dogs stems from tiny differences in a single gene, say researchers. When the team compared the dog DNA samples, they found that all the small breeds shared the same mutations in a small part of the DNA of one gene which regulates the production of insulin-like growth factor (IGF1) - a protein key to promoting growth. . . . "In the big dogs, the [level] of insulin like growth factor is large...

Evolutionarily conserved pathways are emerging as the underlying mechanistic explanation for the relationships observed between maintenance of genomic integrity, control of repair and cell death, and cancer and ageing. From work in C. elegans, the central role of the insulin/insulin‐like growth factor 1 (IGF1) pathway has become apparent. Long‐lived daf‐2 (insulin/IGF1 receptor) mutants counteract tumour growth and promote longevity in C. elegans by triggering apoptosis through the Forkhead box, class O (FOXO) transcription factor DAF‐16; their murine and human homologues are also known to influence tumorigenesis. The transcriptional targets of DAF‐16 were recently found to be involved in extending longevity and include many that influence p53‐dependent apoptosis (Pinkston‐Gosse & Kenyon, 2007). A loss of p53 results in increased cancer incidence in mice and humans; mice that constitutively overexpress p53 are cancer resistant but short lived (Tyner et al, 2002). A large proportion ...

IDDM2-encoded predisposition to type 1 diabetes has recently been mapped to the minisatellite or variable number of tandem repeat (VNTR) locus upstream of the insulin and insulin-like growth factor II genes on human chromosome 11p15.5. In a UK case-control study (n=228 sporadic diabetics; n=441 healthy controls), we show here that the genotype homozygous for VNTR class I alleles is predisposing to disease (RR=2.68), and VNTR class III alleles are dominantly protective (RR=0.37). In 722 diabetic families from the UK (n=356), USA (n=173), Denmark (n=55) and Sardinia (n=138), we have analysed the transmission of class I alleles to diabetic offspring from class I/III heterozygous parents. We confirm that in families from the USA, class I alleles are transmitted preferentially from fathers. However, in family data sets from the UK, Denmark and Sardinia, the reverse is true and maternal transmission is stronger. Furthermore, in the UK family data set, the difference between maternal and paternal ...

Click on a genes description to view its network relationships with genes known to be involved in insulin like growth factor receptor signaling pathway ...

Mecasermin (insulin like growth factor) is classified in this group since it is used on the same indications as somatropin and somatrem. High strength preparations of sermorelin are classified here ...

The IGF axis: circulating IGFs are protected from degradation by forming complex with IGFBPs. IGFs, apart from their local functioning in an autocrine or a para

Hi, Thanks for the query. I think you are talking about XXXXXXX Lorain Dwarfs. 1. XXXXXXX lorain dwarf syndrome-- In this condition there is decrease synthesis of somatomedin C ( a growth hormone in humans). This is also know as HYPOCELLULAR DWARF SYNDROME. Common in Africa. There are others also...

Treatment with recombinant human insulin-like growth factor-I (IGF-I) stimulates linear growth in children with severe IGF-I deficiency (IGFD). To evaluate the efficacy and safety of treatment with IGF-I in patients with severe IGFD treated until adult or near-adult height. Twenty-one children with severe IGFD were treated until adult or near-adult ...

Is John Barbans Venus Factor System a worthy weight loss program? Should you get it? Get your answers in this honest Venus Factor System Review!

Manufacturers information about recombinant human insulin-like growth factor-1, marketed under the brand name Increlex (generic name mecasermin). ...

Any one every try this? DES (1-3) IGF-1 (NOT THE SAME AS IGF-1) Most athletes have heard of IGF-1 (Insulin like growth factor-1) and the amazing

IGF2 antibody (insulin-like growth factor 2 (somatomedin A)) for Neut, WB. Anti-IGF2 pAb (GTX59760) is tested in Human samples. 100% Ab-Assurance.