Classification of Sodium salicylate for effects in the environment: The chemical Sodium salicylate (CAS no. 54-21-7) is used as a denaturant and preservative. Also used as pharmaceutical intermediate.It is used as an analgesic and antipyretic. The aim was to assess whether the PBT criterion within Annex XIII was fulfilled forSodium salicylate. The PBT criterion was herein assessed based on experimental data in conjunction with standardized environmental fate models. Here follows a description of the PBT assessment. 1. Persistence assessment The tested substance does not meet the P criterion within Annex XIII based on the assessment that here follows: 1.1.Overall degradability The 28days closed bottle test was performed in accordance with OECD 301D guidelines, to determine its biodegradability nature. All the study parameters and validity criteria were followed. Based on biochemical oxygen demand, after 28 days of exposure, the degradation was determined to be 88.19%, which suggest that test ...

Several embryotoxic agents, which includes sodium salicylate, were reported to induce vertebral variations in the form of supernumerary ribs (SNR) when administered to pregnant rodents. Because the biological significance of SNR in toxicological studies is still a matter of debate, we investigated the molecular basis of this defect by analyzing the possible involvement of Hox genes, known to specify vertebrae identity. Sodium salicylate (300mg/kg) was administered to pregnant rats on gestational day 9 (GD 9). On GD 13, the expression of several Hox genes, selected according to the position of their anterior limit of expression, namely upstream (Hoxa9), at the level (Hoxa10) and downstream (Hoxd9) to the morphological alteration, were analyzed. Posterior shifts in the anterior limit of expression of Hoxa10 and Hoxd9 were observed following exposure to salicylate, which could explain an effect at the level of the axial skeleton. This finding suggests that the appearance of ectopic ribs can be ...

The chemical formula for sodium salicylate is C7H5NaO3. All of the numbers in the chemical formula for sodium salicylate are subscript numbers in accordance with standard chemical formula...

TY - JOUR. T1 - Effect of sodium salicylate, aspirin, and ibuprofen on enzymes required by the chondrocyte for synthesis of chondroitin sulfate. AU - Hugenberg, S. T.. AU - Brandt, K. D.. AU - Cole, C. A.. PY - 1993. Y1 - 1993. N2 - Objective. To examine the effects of sodium salicylate (Sal), aspirin [acetylsalicylic acid (ASA)] and ibuprofen (Ibu) (as the racemic mixture and the R- and S-enantiomers) on the activities of 2 enzymes involved in the biosynthesis of the hexose components of chondroitin sulfate (CS), i.e., UDP-glucose dehydrogenase (UDP-GD) and glutamine-fructose-6-phosphate-aminotransferase (GFAT), and of glucuronosyltransferase (GT), an enzyme involved in elongation of the nascent CS chain. Methods. UDP-GD and GT were obtained commercially. A homogenate of bovine articular cartilage chondrocytes was employed as a source of GFAT. In each case, enzymatic activity was measured spectrophotometrically. Results. Neither UDP-GD nor GFAT was inhibited by concentrations of Sal, ASA or Ibu ...

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The aim of this study was to compare the effects of transcutaneous electrical nerve stimulation (TENS) and sodium salicylate Iontophoresis on pain and functional disability in patients with osteoarthritis of the knee. Twenty (20) subjects participated in this study. Their ages ranged from 40-65 years. They were assigned to either the TENS or Iontophoresis group. The application of TENS was done using an EV 904 unit made by. Electro-medical supplies, while Iontophoresis treatment was delivered using a Galvanic current machine by F.W. Read and Sons London. The subjects levels of pain and functional disability prior to commencement of treatment and after the 6 weeks of treatment was taken using the Visual Analogue Scale (VAS) and Disability Index Questionnaire for patients with osteoarthritis of the knee joint(s). Analysis of data obtained was done using the Mann-Whitney U test and level of significance was set at (P | 0.05). The statistical analysis of the result showed a statistically significant

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High dose sodium salicylate causes moderate, reversible hearing loss and tinnitus. Salicylate-induced hearing loss is believed to arise from a reduction in the electromotile response of outer hair cells (OHCs) and/or reduction of KCNQ4 potassium currents in OHCs which decreases the driving force for the transduction current. Therefore, enhancing OHC potassium currents could potentially prevent salicylate-induced temporary hearing loss. In this study, we tested whether opening voltage-gated potassium channels using ICA-105665, a novel small molecule that opens KCNQ2/3 and KCNQ3/5 channels, can reduce salicylate-induced hearing loss. We found that systemic application of ICA-105665 at 10 mg/kg prevented the salicylate-induced amplitude reduction and threshold shift in the compound action potentials recorded at the round window of the cochlea. ICA-105665 also prevented the salicylate-induced reduction of distortion products of otoacoustic emission (DPOAE). These results suggest that ICA-105665

This study was designed to determine the dose of salicylate necessary to produce substantial antipyresis, and to determine the relationship between the response to salicylate and prostaglandin infused into the same region of the preoptic area of the rabbit. The effect of preoptic infusions of three doses of sodium salicylate, or a control solution, on the fever produced by an intravenous injection of endogenous pyrogen was measured. The pyrogenic response to prostaglandin E1 injected into the same preoptic sites in the same rabbits was also monitored. The results showed that the 50 μg/μL per hour dose of salicylate did not produce significant antipyresis but that the 100 and 200 μg/μL per hour doses did. The results also showed a significant correlation between the magnitude of fever produced by prostaglandin E1 and the magnitude of antipyresis produced by sodium salicylate at a particular site. Those sites at which infusion of salicylate produced the most effective antipyresis were also the ones at

1 Lees, P. and S.A. May, 1992. Inflammation and anti-inflammatory drugs. Pages 843-863 in: Bovine Medicine. A.H. Andrews, R.W. Blowey, H. Boyd, and R.G. Eddy, ed. Oxford Blackwell Scientific Publications, Cambridge, MA.. 2 Osol, A., R. Pratt, and A.R. Gennaro, 1973. The United States Dispensatory, 27th ed. J.B. Lippincott Co., Philadelphia, PA. .. ...

L. N. Lukoshevichene and S. A. Minina, in: Contemporary Aspects of Investigations in Pharmacy [in Russian], Riga (1977), pp. 87-89.Google Scholar ...

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EWGs Skin Deep rates thousands of personal care product ingredients, culled from ingredient labels on products, based on hazard information pulled from the scientific literature and industry, academic and regulatory databases.

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Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice ...

(2015) Sun et al. Frontiers in Neurology. High dose sodium salicylate causes moderate, reversible hearing loss and tinnitus. Salicylate-induced hearing loss is believed to arise from a reduction in the electromotile response of outer hair cells (OHCs) and/or reduction of KCNQ4 potassium currents ...

Salsalate (sodium salicylate, SA), a cyclooxygenase inhibitor, has been shown to increase insulin sensitivity and to suppress inflammation in obesity and type II diabetes in humans and animals. This study tests the hypothesis that SA (120 mg/kg/day x 4 wks) protects renal nerve function in wild type (WT) but not TRPV1-null mutant (TRPV1-/-) mice fed a western diet (WD for 4 months), accompanying with deteriorated renal function and elevated blood pressure in TRPV1-/- mice fed WD. SA improved glucose tolerance and insulin tolerance in WT-WD-SA and TRPV1-/-WD-SA compared to WT-WD and TRPV1-/-WD groups (P,0.05). Renal pelvis perfusion of capsaicin (CAP, 10-6M), a selective TRPV1 agonist, increased afferent renal nerve activity (ARNA) in WT mice only, with a greater magnitude in WT-WD-SA than in WT-WD mice (P,0.05). Baroreflex (BR) control of renal sympathetic nerve activity (RSNA) in response to IV infusion of sodium nitroprusside (SNP)- or phenylephrine (PE) was improved in WT-WD-SA but impaired ...

Upon taking control of Bayers overall management in 1890, Duisberg began to expand the companys drug research program. He created a pharmaceutical group for creating new drugs, headed by former university chemist Arthur Eichengrün, and a pharmacology group for testing the drugs, headed by Heinrich Dreser (beginning in 1897, after periods under Wilhelm Siebel and Hermann Hildebrandt). In 1894, the young chemist Felix Hoffmann joined the pharmaceutical group. Dreser, Eichengrün and Hoffmann would be the key figures in the development of acetylsalicylic acid as the drug Aspirin (though their respective roles have been the subject of some contention).[2]:65-68[14] In 1897, Hoffmann started working to find a less irritating substitute for salicylic acid. It is generally accepted that he turned to this idea because his father was suffering the side effects of taking sodium salicylate for rheumatism.[2]:68 In 1853, Charles Frédéric Gerhardt had published the first methods to prepare ...

Butasyl is a combination of two non-steroidal anti-inflammatory, both analgesic and antipyretic effect. Sodium salicylate is rapidly metabolized Butasyl

Looking for Antiphlogistic? Find out information about Antiphlogistic. a medicinal preparation that suppresses inflammatory reactions. Antiphlogistics include derivatives of salicylic acid, such as sodium salicylate,... Explanation of Antiphlogistic

Polyester compositions having present a small amount of a salt of salicyclic acid and a cation of a metal from Group IA of the periodic Table of Elements, for example sodium salicylate, have been found to have good crystalization and other properties.

Treatment of premalignant lesions with non-steroidal anti-inflammatory drug increased the presence of immune cells and lessened tumor burden.

Efforts are being made to find ways of restoring the balance between the processes of cell formation and removal to help prevent: the development of polyps. It was found that some of the new, more selective types of aspirin-like drugs, the COX-2 inhibitors, have this effect. Clinical trials with the COX-2 inhibitor, Celebrex (celecoxib) showed that the number of polyps was reduced in FAP patients following treatment for six months. These results subsequently led to approval by regulatory authorities for the product to be marketed for this indication. Unfortunately, it was discovered that there was an increased incidence of heart problems in patients taking the product on a regular basis and so there are concerns over its long-term safety.. It has been known for some years that people who have a high proportion of fish (especially oily fish) in their diet are less likely to suffer from bowel cancer. This has been attributed to the presence of high concentrations of omega-3 fatty acids in fish. ...

Looking for online definition of caffeine and sodium salicylate in the Medical Dictionary? caffeine and sodium salicylate explanation free. What is caffeine and sodium salicylate? Meaning of caffeine and sodium salicylate medical term. What does caffeine and sodium salicylate mean?

1221 medications are known to interact with caffeine/pheniramine/phenylephrine/sodium citrate/sodium salicylate. Includes Adderall (amphetamine/dextroamphetamine), Fentora (fentanyl), Hydergine (ergoloid mesylates).

TY - JOUR. T1 - Swelling behavior of polyhydroxyethyl methacrylate gels in sodium salicylate solutions. AU - Prevysh, V. A.. AU - Siegel, R. A.. PY - 1996/1/1. Y1 - 1996/1/1. UR - http://www.scopus.com/inward/record.url?scp=0029814994&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0029814994&partnerID=8YFLogxK. M3 - Article. AN - SCOPUS:0029814994. SP - 725. EP - 726. JO - Proceedings of the Controlled Release Society. JF - Proceedings of the Controlled Release Society. SN - 1022-0178. IS - 23. ER - ...

div class=citation vocab=http://schema.org/,,i class=fa fa-external-link-square fa-fw,,/i, Data from ,span resource=http://link.collegeofphysicians.org/portal/Fly-poisons--studies-on-sodium-salicylate-a/OfWo4dSnQPg/ typeof=Book http://bibfra.me/vocab/lite/Item,,span property=name http://bibfra.me/vocab/lite/label,,a href=http://link.collegeofphysicians.org/portal/Fly-poisons--studies-on-sodium-salicylate-a/OfWo4dSnQPg/,Fly poisons; : studies on sodium salicylate, a new muscicide, and on the use of formaldehyde,, by Earle B. Phelps, professor of chemistry, and Albert F. Stevenson, sanitary chemist, United States Public health services ..,/a,,/span, - ,span property=potentialAction typeOf=OrganizeAction,,span property=agent typeof=LibrarySystem http://library.link/vocab/LibrarySystem resource=http://link.collegeofphysicians.org/,,span property=name http://bibfra.me/vocab/lite/label,,a property=url href=http://link.collegeofphysicians.org/,College of Physicians of ...

Everybody who reacted to tartrazine, sodium salicylate, or acetaminophen had also reacted to aspirin. 96% of them had sinusitis and 71% had nasal polyps.. The researchers used up to 650 mg aspirin (beginning with a lower dose if sensitivity was suspected), 600 mg sodium salicylate, and 650 mg Tylenol. For the dye, patients were given only 1, 5, 15, 25, and 50 mg of Yellow 5, in incremental doses.. NOTE: At least some of the patients were not on medications at the time of the study. It is not actually clear, but mention was made of those patients whose medications could not be withheld and those receiving troleandomycin.. MedLine ,, Full Text ,, Get Password. ...

Antinuclear Antibody Screen (ANA); Anti Strptolysin-O (ASO); Calcium (Ca); Chem 6 [Blood Urea Nitrogen (BUN); Creatinine; Electrolytes [ Carbon Dioxide (CO2); Chloride (CL); Potassium (K); Sodium (Na) ]; Complete Blood Count [

Gehor-Bosan B8 information about active ingredients, pharmaceutical forms and doses by Professional Health Products, Gehor-Bosan B8 indications, usages and related health products lists

Anyone can be, or become, sensitive to anything, including salicylates. It happens when people or over exposed or continually exposed; however, in the case of salicylates, it usually happens to people with moderate to severe asthma, and then those sufferers develop chronic rhinosinusitis. It also tends to affect older adults or people who have worsening asthma problems, and, yet, the worsening asthma problems may be related to continual exposure to salicylates. So, its a vicious cycle as your health continues to deteriorate, and you experience more and more health problems.. If you have any of the above symptoms, the best way to determine if salicylates is your problem is to begin by eating a diet low in salicylates, and then slowsly add higher salicylate foods back into your diet. For more information on salicylates in food or how to conduct a test see the How Do I Get More Information?section at the bottom of this article. If you have salicylate problems and remove them from your life, your ...

russell at DOGWOOD.BOTANY.UGA.EDU (Russell Malmberg) writes: ,Im looking for both a protocol and a reference for ,the use of sodium salicylate as a fluor for H3, S35, ,and C14 labelled protein acrylamide gels. Ive used 0.5 M salicylate-1.5% glycerol after the water wash for H3-fluorography with good success. The gels dont crack as readily during drying and the signal obtained was strong. (ref. Sambrook, et al. 1989. Molecular Cloning: a laboratory manual). -- Mark S. Strom, Ph.D. office: (206) 553-4182 UR Division, NW Fisheries Sci. Ctr. lab: (206) 553-7707 Natl. Marine Fisheries Ser., NOAA fax: (206) 553-4304 2725 Montlake Blvd. E., Seattle, WA 98112 email: strom at u.washington.edu ...

The salicylate assay aids in the diagnosis and treatment of salicylate overdose and in monitoring salicylate levels to insure appropriate therapy. Salicylates are a group of compounds used as analgesics, antipyretics and anti-inflammatory agents. Acetylsalicylic acid (aspirin) is the most commonly used salicylate. Salicylates are readily available over-the-counter and most salicylate therapy is the result of patient self-medication. For this reason, salicylates are often seen in overdose cases. Salicylate poisoning is seldom fatal, but causes side effects ranging from nausea, vomiting and tinnitus to fever, lethargy and coma. Prompt recognition and management are necessary to avoid serious consequences. ...

There are some reports in ancient medicinal literature that aqueous extracts of the leaves of Teucrium polium show analgesic effects. This prompted us to investigate the analgesic effect of the leaves of the plant using Tail-Flick and Fomalin tests. For this purpose, male NMRI rats weighing 220-260 g were used in all experiments. The aqueous extract of the plant was injected intraperitoneally at doses of 150, 200 and 400 mg/kg. In this study, sodium salicylate (100 and 300 mg/kg) and distilled water were used as positive and negative controls, respectively. The results obtained were analyzed using one-way ANOVA and Tukey-Kramer tests. Our data showed that intraperitoneal injection of aqueous extract of leaves of this plant (150, 200 and 400 mg/kg) produces significant analgesia in both phases of the formalin test (P

Solutions of surfactants in water can be formulated so that rod-shaped micelles are created, which can reduce the drag over what would be experienced with a Newtonian fluid flowing turbulently at the same rate. A solution of 2000 ppm tallow-(tris-hydroxyethyl)-ammonium acetate (or Ethoquad T/13/50) and sodium salicylate is investigated in this study. The instantaneous streamwise and normal velocity fluctuations were measured using LDV for four different Reynolds numbers; $Re\sb{b}$ = 13300, 19100, 3200, and 49100. For a fixed volumetric flow the pressure drop is reduced by 62 to 76 per cent when compared to a Newtonian flow with an equal wall viscosity. Measurements were made of the mean streamwise velocity, the root-mean-square of the streamwise and normal fluctuating velocities, the Reynolds shear stress, and the spectral density function of the fluctuating velocity in the streamwise direction. (Abstract shortened by UMI ...

Salicylates are a group of drugs, including aspirin, that are used to relieve pain and inflammation and to reduce fever. Salicylate testing may be used to detect a high level of salicylate in the blood and help diagnose an overdose (salicylate poisoning).

Choline salicylate + cetalkonium chloride is used in the treatment of .get complete information about choline salicylate + cetalkonium chloride including usage, side effects, drug interaction, expert advice along with medicines associated with choline salicylate + cetalkonium chloride at 1mg.com

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Definition of salicylate in the Definitions.net dictionary. Meaning of salicylate. What does salicylate mean? Information and translations of salicylate in the most comprehensive dictionary definitions resource on the web.

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Salicylate poisoning is a potentially toxic level of salicylate in the blood which may be acute or chronic. Hemodialysis. For chronic salicylate toxicity,

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Magnesium salicylate is an aspirin-like drug used to relieve mild to moderate pain. It is classified as a nonsteroidal anti-inflammatory agent (NSAID)

Salicylates: The salts, esters of salicylic acids, or salicylate esters of an organic acid. Some of these have analgesic, antipyretic, and anti-inflammatory activities by inhibiting prostaglandin synthesis.

Methyl salicylate topical (for the skin) is used for temporary relief of muscle or joint pain caused by strains, sprains, arthritis, bruising, or backaches. Methyl salicylate topical may also be used for purposes not listed in this medication guide.

The clinical manifestations and management of all salicylate intoxications are similar. An overview of salicylate intoxication in children and adolescents will be presented here. General issues relating to the clinical management of drug intoxication

Magnesium salicylate | C14H10MgO6 | CID 64738 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.

Salicylate Poisoning answers are found in the 5-Minute Clinical Consult powered by Unbound Medicine. Available for iPhone, iPad, Android, and Web.

Temporarily relieves minor aches and pains. IODEX with methyl salicylate will relieve local congestion moderating the symptoms: local aches and pains,...

WebMD provides information about interactions between Choline And Magnesium Salicylate Oral and aluminummagnesiumlanthanumsimethicone-oral-thyroid-agents.

Salicylates are ubiquitous agents found in hundreds of over-the-counter and prescription drugs including topical preparations for pain, warts and acne.

Acetaminophen toxicity has been associated with high anion gap metabolic acidosis attributed to 5-oxoproline (Click here to read more), though is less commonly associated with a respiratory alkalosis. This patients normal liver function tests also suggest against acetaminophen toxicity, however should never exclude the diagnosis, as LFT abnormalities may not be seen until many hours after ingestion.. Aspirin, or more specifically salicylates, are also a cause of anion gap metabolic acidosis in overdose. In adults, salicylate toxicity commonly causes a mixed acid-base disorder with a high anion gap metabolic acidosis and a respiratory alkalosis. The respiratory alkalosis is due to dose dependent direct stimulation of the respiratory center causing hyperventilation. This is more commonly found in adults than children. The metabolic acidosis is a result of uncoupling of oxidative phosphorylation and dysfunction at the cellular level.. Management of salicilyate toxicity should always first include ...

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other: In accordance with REACH Annex VIII (8.8) an assessment of toxicokinetic behavior has been conducted to the extent that can be derived from the relevant available information. ...