Despite the importance of extracellular phosphate, the mechanisms and control of intestinal phosphate transport remain unclear. The present study used in vivo and in vitro methods to compare the extent of Na+- dependent versus Na+-independent phosphate transport along the rat small intestine and colon at different luminal phosphate concentrations. Na+-dependent and Na+-independent phosphate transport and genomic expression of type II (NaPi-II) and type III (PiT) transporters in young (3- week old) and adult (8- and 16-week old) animals fed a control or low phosphate diet have also been quantified. mRNA levels of Na+- dependent phosphate transporters have been analysed in the 5/6 nephrectomy model of chronic renal failure and following treatment with matrix extracellular phosphoglycoprotein (MEPE). The acute effects of altered luminal phosphate concentration on intestinal phosphate transport and renal phosphate transporter expression was also assessed. The findings confirm the jejunum to be the ...
The mechanisms and regulation of intestinal phosphate absorption remain poorly defined. This is partly due to known species differences, as well as the variety of techniques and experimental conditions that have been used to assess phosphate absorption, particularly the wide range (and largely unphysiological choice) of phosphate concentrations added to uptake buffers. In the present study we have determined the luminal concentration of phosphate available for absorption, and we have used in vivo and in vitro methods to characterize the relative contributions of Na+‐dependent and Na+‐independent phosphate transport along the rat small and large intestine.. We have used the in vitro, everted sleeve technique developed by Karasov and Diamond (Karasov et al. 1983), and optimized by ourselves for the measurement of phosphate transport at the enterocyte BBM (Marks et al. 2007). Phosphate uptake was measured within the linear phase to ensure unidirectional flux, and that the isotope had not ...
Introduction: Serum phosphate levels are insufficiently controlled in many patients with end-stage renal disease (ESRD), and novel therapeutic strategies are needed. Blocking intestinal phosphate absorption mediated by sodium-dependent phosphate co-transporter type 2b (NPT-IIb) holds promise; thus, we evaluated the efficacy, safety, tolerability, and pharmacokinetics of the novel and specific small molecule NPT-IIb inhibitor ASP3325 for the first time in humans. Methods: We conducted a randomized, double-blind, placebo-controlled, phase 1a single (n = 88) and multiple (n = 36) ascending dose study in healthy subjects, and a randomized, open-label, uncontrolled, phase 1b study in hyperphosphatemic ESRD patients on hemodialysis (single oral dose, n = 5; multiple oral doses, n = 17 ...
Mouse monoclonal antibody MX35 was developed against ovarian cancer. The antibody showed homogeneous reactivity with approximately 90% of human ovarian epithelial cancers and with a limited number of normal tissues by immunohistochemistry. Although mAb MX35 has been used in a number of clinical trials in ovarian cancer, it has been difficult to define the molecular identity of MX35. We report here that mAb MX35 recognizes the sodium-dependent phosphate transport protein 2b (NaPi2b) in human cancer cells. This conclusion is based on several lines of experimental evidence, including 1) the identification of SLC34A2, the gene coding for NaPi2b, by immunoscreening an ovarian cancer cell line cDNA expression library with mAb MX35; 2) mass spectrometry sequencing of peptides obtained by fragmentation from mAb MX35 affinity-purified antigen, which show complete sequence homology to amino acid sequences in NaPi2b; 3) selective down-regulation of SLC34A2 gene expression by RNA interference and the ...
대전광역시 유성구 대학로 245 한국과학기술정보연구원TEL : 042.869.1234 서울시 동대문구 회기로 66NDSL고객센터 : 080.969.4114E-mail : [email protected] 대표자 : 한선화사업자등록번호 : 205-82-04043 ...
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Tenapanor, discovered and developed by Ardelyx, is a first-in-class, proprietary, minimally absorbed, oral, experimental medication in late-stage clinical development. It has a unique mechanism of action that, in hyperphosphatemia, acts by blocking the NHE3 sodium transporter in the GI tract, reducing the absorption of dietary sodium and resulting in increased protons within the cells. The increase in protons causes a reduction in phosphate uptake by tightening junctions or pores that regulate phosphate absorption in the GI tract. Overall, this mechanism appears to be preferential to phosphate absorption given that ...
Abstract: We develop a technique for computing expected numbers of vacua in Gaussian ensembles of supergravity theories, and apply it to derive an asymptotic formula for the index counting all flux supersymmetric vacua with signs in Calabi-Yau compactification of type IIb string theory, which becomes exact in the limit of a large number of fluxes. This should give a reasonable estimate for actual numbers of vacua in string theory, for CYs with small b_3 ...
TY - JOUR. T1 - Bilateral stony lung. T2 - Pulmonary alveolar microlithiasis. AU - Chandra, Subhash. AU - Mohan, Anant. AU - Guleria, Randeep. AU - Das, Prasenjit. AU - Sarkar, Chitra. PY - 2009/5/8. Y1 - 2009/5/8. N2 - A 40-year-old male paddy field worker was referred for exertional shortness of breath and non-productive cough for 4 years. He had been treated for pulmonary tuberculosis twice. Chest radiograph showed extensive bilateral nodular opacities (sandstorm-like) in the middle and lower lobe. Pulmonary function tests revealed a restrictive ventilatory defect. High resolution CT showed widespread nodular infiltration with crazy paving appearance and interrupted black pleura sign. This was confirmed as pulmonary alveolar microlithiasis (PAM) by trans-bronchial lung biopsy, which showed normal respiratory lining epithelium with dilated alveolar spaces containing many calcific bodies, some of which showed concentric calcification. The possibilities of silicosis (due to exposure to husk) and ...
TY - JOUR. T1 - Type 1 sodium-dependent phosphate transporter acts as a membrane potential-driven urate exporter. AU - Miyaji, Takaaki. AU - Kawasaki, Tatsuya. AU - Togawa, Natsuko. AU - Omote, Hiroshi. AU - Moriyama, Yoshinori. PY - 2013. Y1 - 2013. N2 - SLC17A1 protein (NPT1) was the first identified member of the SLC17 phosphate transporter family, and is known to mediate Na+/inorganic phosphate (Pi) co-transport when expressed in Xenopus oocytes. Although this protein was suggested to be a renal polyspecific anion exporter, its transport properties were not well characterized. The clean biochemical approach revealed that proteoliposomes comprising purified NPT1 as the only protein source transport various organic anions such as urate, p-aminohippuric acid (PAH), and acetylsalicylic acid (aspirin) in a membrane potential (δ̄)-driven and Cl- -dependent manner. Human NPT1 carrying an SNP mutation, Thr269Ile, known to increase the risk of gout, exhibited 32% lower urate transport activity ...
A 37-year-old patient was admitted to the hospital with severe dyspnoea and cough. Baseline investigations revealed haemoglobin of 16.2 g/dl, haematocrit of 48.8% and a total leucocyte count of 8800/mm3. Comprehensive metabolic profile and serum and urine protein electrophoresis findings were normal. Arterial blood gas analysis showed type 1 respiratory failure. Spirometry showed restrictive ventilatory disturbances (vital capacity 53%, forced expiratory volume in 1 s 91%). A posterior-anterior chest radiograph showed bilateral diffuse, nodular (sandstorm-like) calcifications in both lungs (figure 1A). A high-resolution CT scan demonstrated multiple bilateral micronodulation of calcific densities throughout both lungs (figure 1B). On transbronchial biopsy, the diagnosis of massive parenchymal and alveolar calcification was confirmed. Echocardiography showed valve calcification with moderate mitral-aortic regurgitation and severe pulmonary hypertension. Abdominal ultrasonography revealed ...
IJARS, About International Journal of Anatomy Radiology and Surgery aims to publish findings of doctors at grass root level and post graduate students, so that all unique medical experiences are recorded in literature.
The aim of this particular study, was to examine the uptake of phosphate by the New Zealand broadleaf Griselinia littoralis with emphasis on the role played by the associated endophytic symbiotic organism of the plant. An attempt was also made to locate the pathway taken by the phosphate in reaching the shoot system of a mycorrhizal plant. Finally, factors affecting this phosphate absorption were examined ...
Rumunsk policie rozbila gang, kter v zemi t ral n meck d ti. Ty na rumunsk venkov p ijely v r mci soci ln ho programu, kter m l napravit jejich problematick dosp v n . M sto pobytu s psychology je tam v ak ekala otrock pr ce, bit a t r n . Celkem policist vy et uj osm lid , p t z nich zatkli.
Ak si máte vybrať správny liek, musíte vedieť koľko stojí, aké má účinky a následne ho porovnať s inými podobne účinnými liekmi z tej istej terapeutickej skupiny (IS).
Ak si máte vybrať správny liek, musíte vedieť koľko stojí, aké má účinky a následne ho porovnať s inými podobne účinnými liekmi z tej istej terapeutickej skupiny (IS).
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Although germinally transmitted ΔMuDR elements are transcriptionally active and produce chimeric sense/antisense transcripts, they have no measurable impact on mudrA transcript levels or Mu1 TIR methylation. As determined by in situ hybridization, antisense mudrA transcripts colocalized with sense mudrA and mudrB transcripts in many tissues of active Mutator plants, and the sense and antisense transcripts may have been paired in vivo (Joanin et al., 1997).. As with documented cases of quelling in fungi, RNA interference in animals, and cosuppression in transgenic plants (reviewed by Matzke et al., 2001; Vance and Vaucheret, 2001), structural properties of ΔMuDR transcripts would be predicted to lead to RNA-based epigenetic gene silencing (Walbot and Rudenko, 2002). Ectopically expressed antisense RNAs are thought to pair with sense transcripts and feed into the double-stranded RNA-induced degradation pathway (Stam et al., 2000; Van Houdt et al., 2000; Serio et al., 2001), and in such cases, ...
FREMONT, Calif., Dec. 2, 2019 /PRNewswire/ -- Ardelyx, Inc. (NASDAQ: ARDX), a specialized biopharmaceutical company focused on developing first-in-class medicines to improve treatment for people with cardiorenal diseases, announced that it will hold a conference call tomorrow, December 3, at 8:00 am Eastern Time to review the results from the pivotal Phase 3 PHREEDOM study evaluating tenapanor in chronic kidney disease (CKD) patients on dialysis. Tenapanor is Ardelyxs investigational, first-in-class, small molecule, non-binder, phosphate absorption inhibitor.. To participate in the conference call, please dial (855) 296-9612 (domestic) or (920) 663-6277 (international) and refer to conference ID 8065608. Live audio of the conference call and accompanying slides will be simultaneously webcast and will be available under the Investors section of the companys website at www.ardelyx.com. The webcast will be archived and available for replay for 60 days following the call.. About Ardelyx, Inc. ...
Female Balb/c mice were oxvariectomed at lactation day 2, pups forced weaned at lactation day 12 to initiate mammary involution. At 24 hours post-weaning, mice were treated with anti-Ly6G antibodies or isotype control. At 48 hours post-weaning, mice were treated with 20µg/kg of body weight estrogen or vehicle control. Mice sacrificed after 24 hours estrogen treatment and mammary sample collected and frozen. Mammary samples were extracted for total RNA using Trizol reagen and then treated ...
A napi j dsz ks glet feln ttben 100-150 mg, terhess gben s szoptat s alatt 200-300 mg. A j dhi nyos euthyreoid strum t els sorban nem kezelni, hanem megel zni kell. A haz nkban alkalmazott m dszer a konyhas j doz sa, azonban ezt felvil gos t kamp nynak kell k s rnie, mivel az zletekben nem j dozott s is kaphat . Terhess g, tervezett terhess g s szoptat s eset n napi 150-200 mg, pubert s sor n napi 100 mg t bbletj d sz ks ges az trendi j dbevitel mellett. Erre lehet s get a j dtartalm tabletta, j dtartalm multivitamin k sz tm nyek, vagy a j dtartalm sv nyvizek jelentenek ...
OBJETIVO: avaliar a qualidade de vida (QV) de mulheres na pós-menopausa usuárias e São Paulo. MÉTODOS: foi conduzido estudo clínico transversal, com 250 mulheres na pós-menopausa, idade entre 45 a 70 anos, atendidas em uma ...
Kateřina Machálková) 2015, Diplomová práce, Fakulta regionálního rozvoje a mezinárodních studií / Mendelova univerzita v Brně. • http://theses.cz/id//evjy4h// , Regional Development / Socioeconomic and Environmental Development of Regions , Práce na příbuzné téma. ...
Sodium-phosphate symporter which seems to play a fundamental housekeeping role in phosphate transport by absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. In vitro, sodium-dependent phosphate uptake is not siginificantly affected by acidic and alkaline conditions, however sodium-independent phosphate uptake occurs at acidic conditions. May play a role in extracellular matrix, cartilage and vascular calcification. Functions as a retroviral receptor and confers human cells susceptibility to infection to amphotropic murine leukemia virus (A-MuLV), 10A1 murine leukemia virus (10A1 MLV) and some feline leukemia virus subgroup B (FeLV-B) variants. This gene encodes a member of the inorganic phosphate transporter family. The encoded protein is a type 3 sodium-dependent phosphate symporter that plays an important role in phosphate homeostasis by mediating cellular phosphate uptake. The encoded protein
Abstract Text: Type II sodium-dependent phosphate co-transporters (NaPi) encoded by the SLC34A gene family are involved in renal and intestinal phosphate (Pi) absorption to maintain plasma Pi content. However, the effects of reduced dietary phosphorus (P) content on the expression of these genes and P utilisation in growing pigs are poorly defined. Thus, an experiment was conducted with fifty-four growing pigs (19.5 ± 1.11 kg BW) to examine the effects of reduced dietary available phosphorus (aP) content on P utilisation and NaPi gene expression. Pigs housed in groups of three per pen were randomly allotted to three experimental diets containing 0.23% (control), 0.17% and 0.11% aP to give 6 observations per diet and had ad libitum access to feed and water. All diets contained 0.3% TiO2 as an indigestible marker. After each wk, one pig per pen was housed in a metabolic crate for twenty-four hours to collect fecal and urine sample and then sacrificed to obtain jejunal and kidney sample. Fecal and ...
Familial idiopathic basal ganglia calcification (IBGC) is a genetic condition with a wide spectrum of neuropsychiatric symptoms, including parkinsonism and dementia. Here, we identified mutations in SLC20A2, encoding the type III sodium-dependent phosphate transporter 2 (PiT2), in IBGC-affected families of varied ancestry, and we observed significantly impaired phosphate transport activity for all assayed PiT2 mutants in Xenopus laevis oocytes. Our results implicate altered phosphate homeostasis in the etiology of IBGC ...
Aim: To study the expression profile of the NaPi2b protein and its localization in breast, ovarian and lung cancer cells in relation to normal tissues adjacent
V posledn dob bylo prok z no, e je u n s p ebytek zem d lsk p dy, kter nen pot ebn k produkci potravin. Podle odhad MZe z r. 2000 se jedn o plochy vhodn k dal mu vyu it o rozloze 465 tis. ha orn p dy a 523 tis. ha luk a pastvin. Celkov plocha tud in t m 1 milion hektar zem d lsk p dy. Bohu el, zna n st t to plochy nen u n s n le it obd l v na, nebo trh potravin je p esycen a odbyt potravin sk produkce je asto problematick . Tato p ebyte n p da b v mnohde zaplevelen a je pak vydatn m zdrojem plevel pro okoln pozemky.
Jedna z nejvzácnějších Hagad, Pražská Hagada, prošla minulý týden digitalizací a nyní je zpřístupněna přes rozhraní Národní knihovny Izraele. Tato Hagada je součástí Valdamonské sbírky judaik, přičemž její vznik se datuje k roku 1556. Z hlediska vyjádření knihovny se jedná o unikátní dílo nejen díky stáří a významnosti, ale rovněž díky ilustracím dřevoryty. Na světě existují…. ...
Jobban v dhetn nk eg szs g nket, ha t bb te t fogyasztan nk, mivel ennek az italnak sz mos kedvez hat sa van. A rendszeres teaiv s r ad sul hozz j rulhat a napi folyad ksz ks glet fedez s hez is.
Műsorvezetők: Jazzkovács László Műsoron: minden hétköznap 16:00-19:00 között Napi rovatokkal, hazavezető útinfókkal, gazdasági és tőzsdei hírekkel, valamint ismert és érdekes meghívott vendégekkel jelentkezünk délutánonként. ...
Life science researchers at the University of Cincinnati were recently awarded $1.6 million from the NIH to study the rare lung disease pulmonary alveolar microlithiasis. Meet science researchers at the 14th Annual BioResearch Product Faire™ Event in Cincinnati in August, 2015.
Mutations in the SLC20A2 gene cause nearly half of all cases of FIBGC. A small percentage of cases are caused by mutations in the PDGFRB gene. Other cases of FIBGC appear to be associated with changes in chromosomes 2, 7, 9, and 14, although specific genes have yet to be identified. These findings suggest that multiple genes are involved in this condition.. The SLC20A2 gene provides instructions for making a protein called sodium-dependent phosphate transporter 2 (PiT-2). This protein plays a major role in regulating phosphate levels within the body (phosphate homeostasis) by transporting phosphate across cell membranes. The SLC20A2 gene mutations that cause FIBGC lead to the production of a PiT-2 protein that cannot effectively transport phosphate into cells. As a result, phosphate levels in the bloodstream rise. In the brain, the excess phosphate combines with calcium and forms deposits.. The PDGFRB gene provides instructions for making a protein that plays a role in turning on (activating) ...
The dihydroflavonol-4-reductase sequence from carnation is inserted in a sense/ antisense orientation. The transcription product results in the formation of a dsDFR which suppress the expression of the endogenous DFR gene, thus allowing dominant expression of the introduced petunia Dihydroflavonol-4-reductase thus leading to the synthesis of delphinidin imparting a violet/mauve colour to the carnation ...
Plakat - E-learning - Polecamy nowoczesne pigmentowe obrazy i zdjęcia na płótnie oraz fototapety w kategorii e-learning. Nasze fotoobrazy giclee wykonujemy na dowolny wymiar. Arteden oferuje również druk na szkle i pleksi oraz frontach meblowych. - strona 1
A terapia fotodinâmica (TFD) é uma modalidade de tratamento que utiliza um fotossensibilizador, luz e oxigênio para gerar espécies reativas de oxigênio capazes de induzir a morte de células indesejadas,...
Pošto sam ja bukvalno odradila sa kolitisom jedan dobar beneficiran radni staž ja sam mislila da bi bilo dobro da napišemo kako je sve počelo, čak pre prvih početaka primećivanja simptoma. Recimo ja, ja sam se sa 13 god žalila na krv u stolici, smejali mi se doktori. Možemo da napišemo neku ispovest, ne mora da bude imenovana ...
Ahojte. Chcel by som sa opýtať, či vie niekto o module (najlepšie free), ktorý by mi dal na stránku tzv. nákupného poradcu. Ide o to, že zákazník na neho klikne, odpovie na pár otázok (klikaním) a nákupný poradca mu vyhodí produkty, ktoré spadajú do kategórií na ktoré zákazník odpovedal. Pomohla by mi každá rada. Vopred ďakujem ...
Nejmodernější vybavení pro zimní sporty a spousta půjčoven je součástí zimního světa ve Ski amadé. Podívejte se na přehled dostupných půjčoven …
Komentář k situaci divadel a kultuře obecně v době pandemie a k návrhům na přesun L. Zaorálka z ministerstva kultury na ministerstvo zahraničí.. ...
ఒక విలక్షణ NPT అమరికలో ఒక చిన్న బల్లపై అమర్చే పరికరాన్ని ఉపయోగిస్తారు; ఉదాహరణకు రోచి కాగుచెక్ ఎస్, ఇంటర్నేషనల్ టెక్నిడైన్ కార్పొరేషన్ హెమోచ్రోన్ సిగ్నేచర్ లేదా మరింత ఇటీవల (2005) పరిచయం చేయబడిన హెమోసెన్స్ ఐఎన్‌రేషియో. కేశనాళిక రక్తం యొక్క ఒక చుక్కను స్వయంచాలకంగా వేలిపై సూదిని గుచ్చడం ద్వారా సేకరిస్తారు, ఈ స్వయంచాలక పద్ధతిలో దాదాపుగా ఎటువంటి నొప్పి లేకుండా రక్తాన్ని ...
236900 - 2/2 - A - in Ruhestellung geschlossen - Druckanschluss 1 (P/NC) | direktwirkend | 2,00 mm | FKM (Fluorkautschuk) | Edelstahl | Innengewinde - NPT | 24,00 V - 24,00 V | -1,00 bar - 25,00 bar | -10,00 °C - 90,00 °C
Calcified pulmonary (lung parenchymal) densities can occur in a number of conditions. Micronodules healed varicella pneumonia 1 pulmonary alveolar microlithiasis occupational lung diseases silicosis coal workers pneumoconiosis stannosis b...
Introdução - O adenocarcinoma de esôfago apresenta aumento de frequência nas últimas décadas, particularmente em países desenvolvidos. O esôfago de Barrett é reconhecido como a principal lesão precursora e o estudo da sequência metaplasia-displasia-adenocarcinoma mostra a ocorrência de alterações genéticas desde suas fases mais incipientes. As alterações no p16INK4a são relatadas como frequentes no esôfago de Barrett e no carcinoma de esôfago. Objetivo - Verificar a prevalência da expressão imunoistoquímica da proteína p16INK4a em exames anatomopatológicos de pacientes com adenocarcinoma de esôfago. Método - A população do estudo foi constituída de 37 pacientes com adenocarcinoma de esôfago. A expressão da proteína p16 foi detectada por meio de análise imunoistoquímica, com anticorpo primário p16INK4aAb-7, clone 16P07, NeoMarkers e avaliada de acordo com o Sistema de Escore de Imunorreatividade (Immunoreactive scoring system - IRS) modificado. Resultados - No ...
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A napi j dsz ks glet feln ttben 100-150 ug, terhess gben s szoptat s alatt 200-300 ug. A j dhi nyos strum t els sorban nem kezelni, hanem megel zni kell. A haz nkban alkalmazott m dszer a konyhas j doz sa, azonban ezt felvil gos t kamp nynak kell k s rnie, mivel az zletekben nem j dozott s is kaphat . M rs kelt j dhi ny eset n j dozott s elegend a sz ks ges bevitel el r s hez, ha naponta egy alkalommal j dozott s felhaszn l s val k sz lt meleg telt fogyaszt a lakoss g. Terhess g, tervezett terhess g s szoptat s eset n napi 150-200 ug, pubert s sor n napi 100 ug t bbletj d sz ks ges az trendi j dbevitel mellett. Terhess g s szoptat s eset n, a j dozott s fogyaszt sa a fokozott sz ks gletet nem fedezi. Erre lehet s get a j dtartalm tabletta, j dtartalm multivitamin-k sz tm nyek, vagy a j dtartalm sv nyvizek jelentenek. J dbevitel (ig ny, ug/nap): Eg szs ges 150, j dhi nyos 300-500, terhess g 200, szoptat s 200, pubert s 200 ...
Ak ste počas protestnej akcie lekárov podali výpoveď a po vypršaní výpovednej lehoty ste sa neprihlásili na úrade práce (ÚP), vašou povinnosťou bolo nahlásiť sa do ôsmich dní v zdravotnej poisťovni (ZP) ako samoplatca
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Az inzulinhi nyos betegek jelenleg nem tehetnek m st, mint injekci ban adj k be maguknak a sz ks ges mennyis g hormont. A napi t bbsz ri szurk l shoz tal n hozz lehet szokni, de az rt sokkal kellemetlenebb, mint meginni egy poh r vizet a szomjolt s rdek ben.