It has been demonstrated previously that ureteral obstruction was associated with downregulation of renal AQP2 expression and an impaired urinary concentrating capacity (Li C, Wang W, Kwon TH, Isikay L, Wen JG, Marples D, Djurhuus JC, Stockwell A, Knepper MA, Nielsen S, and Frokiaer J. Am J Physiol Renal Physiol 281: F163-F171, 2001). In the present study, changes in the expression of major renal Na transporters were examined in a rat model with 24 h of unilateral ureteral obstruction (UUO) to clarify the molecular mechanisms of the marked natriuresis seen after release of UUO. Urine collection for 2 h after release of UUO revealed a significant reduction in urinary osmolality, solute-free water reabsorption, and a marked natriuresis (0.29 +/- 0.03 vs. 0.17 +/- 0.03 micromol/min, P < 0.05). Consistent with this, immunoblotting revealed significant reductions in the abundance of major renal Na transporters: type 3 Na(+)/H(+) exchanger (NHE3; 24 +/- 4% of sham-operated control levels), type 2 ...

Acts as a membrane potential-dependent organic anion transporter, the transport requires a low concentration of chloride ions. May be involved in urate extrusion from the intestinal duct. May recognize hydrophilic anionic drugs such as aspirin, salicylate, and ibuprofen as substrates. Able to actively transport inorganic phosphate into cells via Na(+) cotransport (in vitro). Phosphate homeostasis is maintained by regulating intake, intestinal absorption, bone deposition and resorption, and renal excretion of phosphate. The central molecule in the control of phosphate excretion from the kidney is the sodium/phosphate cotransporter NPT1 (SLC17A1; MIM 182308), which is located in the renal proximal tubule. NPT1 uses the transmembrane electrochemical potential gradient of sodium to transport phosphate across the cell membrane. SLC17A4 is a similar sodium/phosphate cotransporter in the intestinal mucosa that plays an important role in the absorption of phosphate from the intestine (summary by Shibui et al.,

About the Home Treatment Unit. The results from treatment with microcurrent stimulation are very optimistic. Not all electrical stimulation is the same, and the improvements in vision seen with our current treatment protocol are felt to be due to refinements and improvements in the specific devices used. These devices deliver currents much closer to the level of currents found naturally in the body. Other devices use levels of current which are much stronger. Stronger does not always mean better. The waveform and quality of the microcurrent output of the MicroStim 100i Le device seems particularly effective in stimulating the retina when the stimulation is applied to points around the eyes and points on the surface of the body related to the eye.. This particular machine is current-driven rather than voltage-driven. This means that this machine is able to adjust for varying resistance, and provide a stable level of current. Whereas a voltage-driven machine provides a current driven by ...

Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint ...

BK channels pass large potassium (K+) currents across the cell membrane to maintain the electrochemical balance in excitable cells. They are composed of four identical α subunits, called mSlo1, accompanied by different modulatory β subunits. mSlo1 contains three distinct domains: a membrane-spanning pore-gate domain, a transmembrane voltage-sensing domain (VSD), and a cytoplasmic domain containing binding sites for calcium ions. This cytoplasmic domain joins with those of the other mSlo1 subunits to form a structure called the gating ring. Accordingly, mSlo1 channels will open either in response to shifts in membrane voltage or to binding of calcium at the gating ring (2). Calcium binding can also enhance voltage-driven channel activity and vice versa (3).. The mechanism by which calcium binding and voltage-dependent channel activation affect each other was unclear, says Jianmin Cui, a Professor at Washington University in St. Louis, but we were inspired by a recent paper which showed that ...

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Connect and collaborate with Na Li at Emergent BioSolutions Inc, with research interests in statistics and clinical trial, on Mendeley.

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Author: Nalbant, P. et al.; Genre: Other; Published in Print: 1999; Title: PDZ-domain interaction of the Na/P-i cotransporter type II

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Med letoma 1618 in 1639 je nastalo bojišče med konkurenčnimi frakcijami v času Bündner Wirren (Zmeda Graubündena ali zmedenost Lig). Protestantsko stranko sta podprli Francija in Benetkami, katoliško stranko pa Habsburžani v Španiji in Avstriji. Vsaka stran je poskušala pridobiti nadzor nad Graubündenom in nadzor nad pomembnimi alpskimi prelazi. Leta 1618 je mladi radikalec Jörg Jenatsch postal član sodišča kleričnih nadzornikov in vodja anti-habsburške frakcije. Nadziral je mučenje do smrti duhovnika Nicola Rusca iz Sondria. V odgovor je Giacomo Robustelli iz pro-katoliške družine Planta, organiziral vojsko upornikov v Valtellinu. Na večer 18/19 julija 1620 so sile upornikov iz Valtellina, podprti s strani avstrijskih in italijanskih vojakov, vkorakale v Tirano in začele pobijati protestante. Ko so končali v Tirani, so korakali na Teglio, Sondrio in nadalje po dolini pobili vsakega protestanti, ki so ga našli. Med 500 in 600 [7] ljudi je bilo ubitih v tej noči in v ...

V sodobnem času je vrsto človek, verjetno ob trgovanju s čebulicami in rezanim cvetjem, zanesel v Severno Ameriko, pa tudi na Britansko otočje in Skandinavijo, kjer se zdaj ob odsotnosti naravnih sovražnikov intenzivno širi.[1] V Združenem kraljestvu so jo prvič opazili leta 1940 in nekaj let kasneje še na vzhodu Kanade. Od tam se je do konca 20. stoletja razširila proti jugu na vzhodni del Združenih držav Amerike, leta 2011 pa so jo našli tudi v okolici Seattla na zahodni obali. Pri tem je vrsto ločeno opisal Thomas Say v 19. stoletju kot Lema melanocephala po primerkih iz Severne Amerike, tako da je bila vrsta tam očitno prisotna že prej. Njegov opis so ob kasnejši reviziji proglasili za sinonim škrlatne lilijevke.[4] Škodo povzroča predvsem v Severni Ameriki, kjer so odsotni naravni sovražniki, ki v izvornem območju razširjenosti omejujejo njeno številčnost. Zaradi hitrega razmnoževanja se lahko škrlatne lilijevke v ugodnih pogojih močno namnožijo in uničijo ...

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Glivične okužbe pljuč je težko zdraviti , saj so glivične celice zelo podobne človeških celic ( eukaryotic ) . Zato je izziv , da bi našli droge za napad patogena, brez povzročanja škode na gostitelja . Patogene glive so pogosto Dimorfan , kar pomeni, da lahko rastejo bodisi kot plesni ali kvasovk , odvisno od temperature , ki jih uspevajo pri telesni temperaturi ljudi in delajo tudi v vlažnih pogojih, najdemo v človeških tkivih . Glivične okužbe pljuč so pogosto zamenjajo za nekaj drugega , kot so bakterijske pljučnice , tuberkuloza , gripa ali celo raka. Včasihglivična okužba lahko obstaja že nekaj časa , preden se jepravilna diagnoza (čeprav se to ne zgodi tako pogosto, kot je nekoč ) . Ni važno, kaj gliva gre , so simptomi zelo podobni . Endemične Glivične okužbe ...

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TY - JOUR. T1 - The extracellular loop of pendrin and prestin modulates their voltage-sensing property. AU - Kuwabara, Makoto F.. AU - Wasano, Koichiro. AU - Takahashi, Satoe. AU - Bodner, Justin. AU - Komori, Tomotaka. AU - Uemura, Sotaro. AU - Zheng, Jing. AU - Shima, Tomohiro. AU - Homma, Kazuaki. PY - 2018/1/1. Y1 - 2018/1/1. N2 - Pendrin and prestin belong to the solute carrier 26 (SLC26) family of anion transporters. Prestin is unique among the SLC26 family members in that it displays voltage-driven motor activity (electromotility) and concurrent gating currents that manifest as nonlinear cell membrane electrical capacitance (nonlinear capacitance (NLC)). Although the anion transport mechanism of the SLC26 proteins has begun to be elucidated, the molecular mechanism of electromotility, which is thought to have evolved from an ancestral ion transport mechanism, still remains largely elusive. Here, we demonstrate that pendrin also exhibits large NLC and that charged residues present in one ...

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We study the function and regulation of Na transporters in the surface membrane of mammalian cells, recently with a focus on the regulation of transporte..

Many find low-phosphate detergents as appealing as low-flow showers, underscoring the tradeoffs people often face in a more environmentally conscious marketplace.

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