Epithelial ovarian cancer is a fatal disease, with a cure rate of only 30%. Several recent studies have targeted integrins for cancer treatment. Preclinical studies have shown the effectiveness of several integrin inhibitors for blocking cancer progression, especially by blocking angiogenesis. Because the initial critical step in ovarian cancer metastasis is the attachment of cancer cells to the peritoneum or omentum and because clinical trials have provided positive results for anti-angiogenic therapy, therapies targeting integrins may be the most feasible approach for treating cancer. This review summarizes the current understanding of integrin biology in ovarian cancer metastasis and various therapeutic approaches involving integrin inhibitors. However, no integrin inhibitor has shown favorable results thus far. However, conjugates of cytotoxic agents with the triplet sequence arginine-glycine-aspartate (RGD) peptides targeting α5β1-, αvβ3-, and αvβ6-integrins may be promising integrin

Snake venom metalloproteinases (SVMPs) are predominant in viperid venoms, which provoke hemorrhage and affect hemostasis and thrombosis. P-I class enzymes consist only of a single metalloproteinase domain. Despite sharing high sequence homology, only some of them induce hemorrhage. They have direct fibrin(ogen)olytic activity. Their main biological substrate is fibrin(ogen), whose Aα-chain is degraded rapidly and independently of activation of plasminogen. It is important to understand their biochemical and physiological mechanisms, as well as their applications, to study the etiology of some human diseases and to identify sites of potential intervention. As compared to all current antiplatelet therapies to treat cardiovascular events, the SVMPs have outstanding biochemical attributes: (a) they are insensitive to plasma serine proteinase inhibitors; (b) they have the potential to avoid bleeding risk; (c) mechanistically, they are inactivated/cleared by α2-macroglobulin that limits their range of

Title:Snake Venom Proteins: Development into Antimicrobial and Wound Healing Agents. VOLUME: 11 ISSUE: 1. Author(s):Ramar Perumal Samy, Jayapal Manikandan, Gautam Sethi, Octavio L. Franco, Josiah C. Okonkwo, Bradley G. Stiles, Vincent T.K. Chow, Ponnampalam Gopalakrishnakone and Mohammed Al Qahtani. Affiliation:Venom and Toxin Research Programme, Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597.. Keywords:Methicillin-resistant Staphylococcus aureus (MRSA), snake venom protein, endogenous antibiotics, Lys49 & Asp49-PLA2, inflammatory cytokines, growth factors, skin, wound healing, transcription factors NF-kB, Cys-rich protein.. Abstract:Infectious diseases are a significant cause of morbidity and mortality worldwide, accounting for approximately 50% of all deaths in tropical countries and as much as 20% of deaths in the USA. The emergence of multi-drug resistant (MDR) strains makes the risk of these infections even more threatening and an ...

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Title: Hypotensive Agents from Snake Venoms. VOLUME: 4 ISSUE: 4. Author(s):Roy Joseph, Susanta Pahari, Wayne C. Hodgson and R. Manjunatha Kini. Affiliation:Department of Biological Sciences, Faculty of Science, National University of Singapore, 14 Science Drive 4, Singapore 117543.. Keywords:bradykinin potentiating peptides, natriuretic peptides, sarafatoxin, endothelin, calciseptine, conotoxins and calcium current, vascular permeability, l-type calcium channel, cardiovascular effects. Abstract: Many snake venoms contain toxins which produce profound cardiovascular effects. The site of action of these toxins includes cardiac muscle, vascular smooth muscle and the capillary vascular bed. Some snake venoms, for example, contain peptides that inhibit angiotensin converting enzyme and potentiate the biological actions of bradykinin. Other snake venoms contain structural and functional equivalents of mammalian natriuretic peptides. Sarafotoxins are short peptide toxins found in the venoms of snakes ...

PRIMARY OBJECTIVES:. I. To determine the objective response rate to cilengitide in younger patients with recurrent or progressive high-grade glioma that is refractory to standard therapy.. SECONDARY OBJECTIVES:. I. To estimate the distribution of time to progression, time to treatment failure, and time to death in these patients.. II. To estimate the rate of toxicity, especially symptomatic intratumoral hemorrhage, in these patients.. III. To evaluate the pharmacokinetics of cilengitide in plasma using a limited sampling strategy.. IV. To evaluate the pharmacogenetic polymorphisms in drug transporters (eg, breast cancer resistance protein [BCRP], P-glycoprotein [P-gp]) and relate to cilengitide disposition.. OUTLINE:. Patients receive cilengitide IV over 1 hour on days 1, 4, 8, 11, 15, 18, 22, and 25. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.. After completion of study treatment, patients are followed up every 3 months for 2 years and then ...

There is no way to find out by just reading this, but Ive heard a lot about snake venom deforming tissues after exposure, now Im not saying that you should just take some venom and the penis will get bigger. But what Im suggesting that further studies of snake venom and the reactions of tissue under controlled environments might lead the way to understand the benefits of tissue deformation without death. There is an antidote for the snake venom if bitten in the wild, it uses a plant of some kind which acts alone in some cases and target the venom in the nervous system rendering the venom useless as it deforms the cells.. Could a controlled dose of venom mixed with another tissue isolating chemical change the size of cells in the penis? Could such a thing be possible? Its a long shot so dont all laugh at once, but its the ideas that people have that spark discovery.. Here is some facts on what people are trying.. The relationship between microstructural features and macroscopic mechanical ...

Snake venoms contain a number of proteins that interact with components of the haemostatic system that promote or inhibit events leading to blood-clot formation. The snake-venom protein convulxin (Cvx) binds glycoprotein (GP) VI, the platelet receptor for collagen, and triggers signal transduction. Here, the 2.7 A resolution crystal structure of Cvx is presented. In common with other members of this snake-venom protein family, Cvx is an alphabeta-heterodimer and conforms to the C-type lectin-fold topology. Comparison with other family members allows a set of Cvx residues that form a concave surface to be putatively implicated in GPVI binding. Unlike other family members, with the exception of flavocetin-A (FL-A), Cvx forms an (alphabeta)(4) tetramer. This oligomeric structure is consistent with Cvx clustering GPVI molecules on the surface of platelets and as a result promoting signal transduction activity. The Cvx structure and the location of the putative binding sites suggest a model for this

Snake venom is a highly complex cocktail of proteins, peptides, non protein toxins, carbohydrates, lipids, amines and other molecules. The chemical composition of venom varies at all taxonomic levels. Further, composition can vary considerably between snakes in different geographical locations and individuals within those populations. The composition is also subject to change based on diet, age, season and environment. The widely differing manifestations of snake bite could be attributed to complexity of venom to some extent.. The snake venom mainly contains proteins (,90%, dry weight). There are more than hundred different proteins in each venom; with elapid and viperid venoms constituting 25-70% and 80-90% of enzymes respectively. Some non-enzymatic polypeptide toxins and non-toxic proteins are also present. The snake venoms are mainly characterized as neurotoxic and hemotoxic. The neurotoxic venoms act at molecular level, by disrupting the neuromuscular junctions, limiting muscle activity ...

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My laboratory, in collaboration with my colleague Dr. Jon Bjarnason, was one of the first to identify and characterize the metalloproteinases present in numerous snake venoms. These Snake Venom Metalloproteinases; SVMPs are responsible for many of the pathologies associated with snake envenoming. Our research has elucidated the structures of these toxins and identified the biochemical and cellular mechanisms by which the toxins function to give rise to their noted pathologies. Specifically my research interests have been centered on metalloproteinases and extracellular matrix and the processes they regulate in normal and pathological circumstances. Our recent focus has expanded to include the interaction of host and tumor in carcinogenesis and metastasis and the role of stromal microenvironment, inflammation in cancer metastasis and invasion. We are also carrying out research on the discovery and validation of biomarkers associated with normal and chronic wound healing. Our longstanding interest ...

PRODUCT DETAILS Serum by ItS SKIN. Highly effective serum containing SYN-AKE® peptides which mimic the action of snake venom. Wrinkles are frozen, preventing formation of new creases and lines to give a more evenly toned complexion. Delivers deep moisture and vitamins to the skin. Hydration through many levels of skin. Soft texture with enriched essence. Apply to clean skin and leave on , snake venom whitening anti ageing ...

A nanofiber hydrogel infused with snake venom may be the best material to stop bleeding quickly, according to Rice University scientists., A nanofiber hydrogel infused with snake venom may be the best material to stop bleeding quickly, according to Rice University scientists.

Study Highlights: In preliminary research, an antiplatelet drug based on a snake venom protein prevented blood clotting without leading to excessive bleeding, a dangerous side effect of currently available antiplatelet drugs. The venom protein may be the template for a new class of antiplatelet drugs that offers fewer bleeding complications.

Snake Venom + Collagen Wrinkle Filler Eye Cream 15ml Formulated for: Wrinkles and fine lines Loss of firmness Uneven skin tone Wrinkle Filler Eye Cream is specially formulated for crows feet and fine lines and wrinkles around the eye area. It contains

Scientists have found that a snake venom can provide a safer alternative to drugs like aspirin that help prevent blood clots in heart disease patients. Antiplatelet drugs prevent blood cells called platelets from clumping together and are widely used to treat heart disease.

A nanofiber hydrogel infused with snake venom may work better than anti-coagulants to stop bleeding quickly, a new study suggests.

This phase I trial is studying the side effects and best dose of cediranib maleate when given together with cilengitide in treating patients with progre

Subjects in Groups 2 and 3 will receive a single dose of 2000mg of cilengitide as 1-hour i.v. infusion. Subjects from group 4a will receive a single dose of 1000mg of cilengitide as 1-hour i.v. infusion . PK samples will be collected and basic PK parameters will be calculated. The safety, tolerability, and PK will be evaluated by the Safety Monitoring Committee (SMC). If the SMC has no concerns, Group 4b will be treated with a higher dose (up to 2000mg) of cilengitide. Then, Group 1 (healthy subjects) will be started after the last subject with renal impairment (in either Group 2, 3, or 4a; or in Group 4b, if applicable) has completed all activities on Day 3. They will also receive a single dose of 2000mg of cilengitide as 1-hour i.v. infusion.. The duration of the trial from the first subject enrolled to the last subject last visit will be approximately 6 months (approximately 8 months, in case Group 4b is included). Each subject will participate in the trial for up to 35 days, including ...

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The present invention identified a high affinity binding sequence in collagen type III for the collagen-binding integrin I domains. Provided herein are the methods used to characterize the sequence, the peptides comprising this novel sequence and the use of the peptides in enabling cell adhesion. Also provided herein are methods to identify specific integrin inhibitors, sequences of these inhibitors and their use in inhibiting pathophysiological conditions that may arise due to integrin-collagen interaction ...

Lippa, Rhys A. and Barrett, John and Pal, Sandeep and Rowedder, James E. and Murphy, John A. and Barrett, Tim N. (2020) Discovery of the first potent and selective αvβ5 integrin inhibitor based on an amide-containing core. European Journal of Medicinal Chemistry, 208. 112719. ISSN 0223-5234 Smith, Andrew J. and Dimitrova, Daniela and Arokianathar, Jude N. and Clark, Kenneth F. and Poole, Darren L. and Leach, Stuart G. and Murphy, John A. (2020) Et3SiH + KOtBu provide multiple reactive intermediates that compete in the reactions and rearrangements of benzylnitriles and indolenines. Chemical Science, 11 (45). pp. 12364-12370. ISSN 2041-6520 Lawson, Connor A. and Dominey, Andrew P. and Williams, Glynn D. and Murphy, John A. (2020) Visible light-mediated smiles rearrangements and annulations of non-activated aromatics. Chemical Communications, 56 (77). pp. 11445-11448. ISSN 1359-7345 Rohrbach, Simon and Murphy, John A. and Tuttle, Tell (2020) Computational study on the boundary between the ...

In the process of study, researchers first created a drug that interacts with the receptor found on the exterior of the blood clotting cells. The protein was then mixed with the blood and introduced into the bodies of mice.. The results obtained showed slower blood clot formation in mice having the protein in their system than those without. The protein in the venom interacted with the GPVI, the receptor on the cells, and resultantly inhibited the blood clot formation.. According to another significant benefit revealed in the research, the protein also did not cause the excessive bleeding which is the common side effect of the concurrent medicines used in the treatment.. ...

Shahid Akhter, editor, ETHealthworld spoke to Zoltan Takacs, Founder and CEO, World Toxin Bank ToxinTech Inc, US, to know more about the animal venom toxins a..

ElishaCoy Syn-ake Velvet Skin lotion not only cultivates smoother but also improve the skins elasticity with peptides similar to those found in snake venom and epithelial cell growth enhancing EGF.... Learn More ...

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TY - JOUR. T1 - Accelerated evolution of snake venom phospholipase A2 isozymes for acquisition of diverse physiological functions. AU - Ogawa, Tomohisa. AU - Nakashima, Kin Ichi. AU - Nobuhisa, Ikuo. AU - Deshimaru, Masanobu. AU - Shimohigashi, Yasuyuki. AU - Fukumaki, Yasuyuki. AU - Sakaki, Yoshiyuki. AU - Hattori, Shosaku. AU - Ohno, Motonori. PY - 1996/11. Y1 - 1996/11. N2 - The nucleotide sequences of two cDNAs and four genes encoding Trimeresurus gramineus venom gland phospholipase A2 (PLA2) isozymes were determined and compared internally and externally with those encoding Trimeresurus flavoviridis venom gland PLA2 isozymes. It was reveald that the protein-coding regions are much more diversified than the 5 and 3 untranslated regions (UTRs) and the introns except for the signal peptide domain. The numbers of nucleotide substitutions per site (K(N)) for the UTRs and the introns were approximately one-quarter of the numbers of nucleotide substitutions per synonymous site (K(s)) for the ...

Snakebite envenoming is a serious condition requiring medical attention and administration of antivenom. Current antivenoms are antibody preparations obtained from the plasma of animals immunised with whole venom(s) and contain antibodies against snake venom toxins, but also against other antigens. In order to better understand the molecular interactions between antivenom antibodies and epitopes on snake venom toxins, a high-throughput immuno-profiling study on all manually curated toxins from Dendroaspis species and selected African Naja species was performed based on custom-made high-density peptide microarrays displaying linear toxin fragments. By detection of binding for three different antivenoms and performing an alanine scan, linear elements of epitopes and the positions important for binding were identified. A strong tendency of antivenom antibodies recognizing and binding to epitopes at the functional sites of toxins was observed. With these results, high-density peptide microarray ...

Cyclo(RGDyK) trifluoroacetate is a potent and selective αVβ3 integrin inhibitor with an IC50 of 20 nM. - Mechanism of Action & Protocol.

A University of Arizona researcher developing a therapy to prevent or delay the dangerous results of rattlesnake and other venomous snakebites in humans has shown that a combination of carbon monoxide and iron inhibits snake venoms effects for up to an hour in animals, a major advance in bringing the treatment to market.. Snake venom is hemotoxic-destructive to the ability of blood to clot-and can cause the destruction of fibrinogen, an essential protein that enables blood to clot and stop excessive bleeding. Snake-venom enzymes also can cause abnormally fast clotting, which can lead to heart attack, stroke and damage to the bodys organs. Both reactions are inhibited by the therapy.. Vance G. Nielsen, professor and vice chair for research in the Department of Anesthesiology at the UA College of Medicine - Tucson, has confirmed that, if given soon enough after a snake bite, the carbon monoxide-iron-based therapy directly can inhibit snake venoms ability to block blood clotting in laboratory ...

PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.

Gift box comprises a broad-spectrum ointment with Snake venom having antirheumatic and antispastic effect (75 ml), anti-wrinkle face cream with Snake venom - anti-age care for all skin types (50 ml)

Snake Venom Antisera : medicine prices in Pakistan at WhatPriceDrugs.com. List of Medication containing Snake Venom Antisera. Get information about generic, dosage forms, pack sizes and latest price.

It is estimated that every year, over 100,000 human deaths can be attributed to snakebite from the worlds 700 venomous snake species -- all inflicted in self-defence when the snakes feel threatened by encroaching humans. However, a new piece of research concludes that snake venom did not evolve as a defence mechanism.

Neck, lumbar and pelvic vertebrae are very reduced in number only 2-10 lumbar and pelvic vertebrae are present , while only a short tail remains of the caudal vertebrae. Amphibians and reptiles portal. An older snake may shed its skin only once or twice a year. The probe is marked at the point where it stops, removed, and compared to the subcaudal depth by laying it alongside the scales. More advanced snakes have no remnants of limbs, but basal snakes such as pythons and boas do have traces of highly reduced, vestigial hind limbs. Cobras, vipers, and closely related species use venom to immobilize or kill their prey. This process leads to genome wide homozygosity , expression of deleterious recessive alleles and often to developmental abnormalities. Snakes use smell to track their prey. It is reconstituted with sterile water and becomes antivenom. More than 20 families are currently recognized, comprising about genera and about 3, species. King cobras and the Australian bandy-bandy consume other ...

The origin of snake venom has long been a mystery to both creationists and evolutionists. However, by stepping outside the standard research paradigm, scientists recently showed that snake venom proteins may have arisen from existing salivary proteins.1. The Bible indicates that at the beginning of creation, Gods handiwork was not fraught with death, disease, and violence. Because of Adam and Eves rebellion, creation became subject to all of these negative factors, including snakes with toxic venom. The question then arises of how the curse on creation brought about these deadly changes. Were new genes of malicious intent added by the Creator, or was pre-existing genetic information corrupted or altered in some way? According to what we know about genomic decay and the character of God as revealed in the Bible, it is more likely that genomic modification, possibly associated with degradation (genetic entropy), was the cause.2,3. On the other side of the scientific paradigm lies the ...

Curious to know about venom and its usage! Snake Venom means snakes poison. Stay away from it. Venom is poisonous fluid generate by animals such as snakes,

Introduction: Snake venom is adapted saliva that is formed by distinct glands of only certain species of snakes. The gland which secretes ...

Due to its various structures in bio-compounds, snake venom is the indisputable result of evolutionary stages of molecules with an increasingly complex structure, high specificity, and of great importance for medicine because of their potential. 4.50, 7.00, 15.00, 28.00, 46.00, 63.00, 95.00, 150.00, 240.00 kDa. The screening revealed the presence of compounds with a molecular weight greater than 80 kDa, in the case of and and genus using a useful and replicable methodology. The extension of protein fractions evaluation in the field up to 230 kDa allows the identification of fractions Torisel price that are insufficiently studied so far, including both their structures and their biological effects. Material and Methods Venom collection In all cases, animal manipulation, including snakes harvesting, was good UNC Institutional Pet Make use of and Treatment Committee authorized protocols, and none from the pets were for the International Union for Conservation of Character threatened varieties ...

Snake venoms affect bloodstream coagulation and platelet function inside a organic way. A23187 with identical IC50 concentrations. They neither influence shape modification nor the cAMP level. Further research demonstrated that trigramin and echistatin purified from and venom, which like RUC-2, got a minor priming impact in induction of fibrinogen-binding or PAC-1 binding, reflecting that TMV-7 induces small publicity of LIBs (unpublished data). It binds ideally to IIb, a binding epitope not the same as those of mAb 7E3, tirofiban, eptifibatide & most RGD-containing disintegrins including dimeric disintegrin, and brief- and medium-size disintegrins. TMV-7 in addition has been shown to become an efficacious antithrombotic agent in FeCl3-induced carotid artery damage, and irradiation-induced mesenteric thrombosis versions. At effective dosages, TMV-7 didnt significantly extend the bleeding period. Its unique system of action could be linked to inhibiting outside-in signaling without influencing ...

Some characteristics of the local tissue damage and inflammatory reactions induced by snake venoms were analyzed in a mouse model. Tissue damage was studied by intravital, light, and electron microscopic techniques, and by the use of biochemical markers. Detailed information on the early development and dynamics of local tissue damage was obtained by intravital microscopy. Main alterations were microvascular plasma leakage, hemorrhage, blood flow disturbances, thrombosis, and myonecrosis. A new technique for the quantification of myonecrosis in vivo was established, based on the principle of MTT reduction. The method was tested for its usefulness in the evaluation of antibody-mediated neutralization of myotoxicity. The inflammatory response to venom included early lymphopenia and neutrophilia, thrombocytopenia, with edema and leukocyte extravasation at the site of injection. A rapid plasma peak of IL-6 was induced by venoms, as well as by purified muscle-damaging and hemorrhagic toxins, in ...

No-one saw the large Eastern Brown snake until they looked at the pics later, veteran handler Barry Goldsmith wrote on Facebook, saying it really goes to show snakes are not aggressive.

HONG, TAN NGET (2009) Snake venom L-amino acid oxidase. In: CRC Handbook of Venoms and Toxins of Reptiles. Taylor and Francis / CRC Press, pp. 219-234. ...

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature protease. The encoded protease functions in the ectodomain shedding of tumor necrosis factor-alpha, in which soluble tumor necrosis factor-alpha is released from the membrane-bound precursor. This protease also functions in the processing of numerous other substrates, including cell adhesion proteins, cytokine and growth factor receptors and epidermal growth factor (EGF) receptor ligands. The encoded protein also plays a prominent role in the activation of the Notch signaling pathway. Elevated expression of this gene has been observed in specific cell types ...

Snake venom is highly modified saliva containing zootoxins which facilitates the immobilization and digestion of prey, and defends against threats. It is injected by unique fangs after a bite, and some species are also able to spit. The glands that secrete the zootoxins are a modification of the parotid salivary gland found in other vertebrates, and are usually situated on each side of the head, below and behind the eye, and encapsulated in a muscular sheath. The glands have large alveoli in which the synthesized venom is stored before being conveyed by a duct to the base of channeled or tubular fangs through which it is ejected. Venoms contain more than 20 different compounds, mostly proteins and polypeptides. A complex mixture of proteins, enzymes, and various other substances with toxic and lethal properties serves to immobilize the prey animal, enzymes play an important role in the digestion of prey, and various other substances are responsible for important but non-lethal biological ...

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The expression of this gene is testis-specific. [provided by RefSeq, Jul 2008 ...

Bochra Tourki, Anaïs Dumesnil, Claire Arnaud, Elise Belaidi Corsat, Vincent Richard, et al.. Lebetin 2, a snake venom natriuretic-like peptide and BNP exert cardioprotective effects against ischemia-reperfusion injury in vivo. Fundamental and Clinical Pharmacology, Wiley, 2016, 8 (3), ⟨10.1016/S1878-6480(16)30416-5⟩. ⟨pasteur-01471775⟩ ...

DO YOUR HOMEWORK PEOPLE, Lisinopril is NOT made from snake venom. Blood pressure meds were developed from INFORMATION that was obtained by recogniz...

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. It is reported that inactivation of this gene is associated with tumorigenesis in human cancers. [provided by RefSeq, May 2013 ...

Cilengitide in patients with recurrent glioblastoma: The results of NABTC 03-02, a phase II trial with measures of treatment delivery Academic Article ...

Sanofi Reports Results of Toujeo (insulin glargine 300 Units/mL) in P-III EDITION JUNIOR Study in Children and Adolescents with Type 1 Diabetes

Snake icons - 0 Free Snake icons | Download PNG & SVG Popular Styles including Glyphs, Flat, Outline, Filled, and Hand Drawn. You may also like: snake vector, snakes and ladders, frog, spider, snake skin, cobra, snacks, dragon, lizard

Snake venom is sometimes used as medicine; recent research has shown that snake venom may have value in treating cardiovascular diseases.

Heres something thats strange. One of my old P-III machines got a workunit that only took about half as long as it should have to crunch. My wingman, running an Athlon64 3500+, took only about 5000 seconds less than I did with the P-III. Yet, the results validated okay.. Something just doesnt seem right with this.. Strange P-III results. ...

In our first ten years here, we had only three sightings of these, and it wasnt until the third sighting (in April 2016) that I had a camera with me. This snake announced its presence in an audible manner. I paused, looked around, and saw a patterned brown snake emerging from the vegetation where I had heard the rattling sound. From about 10 feet away, I strained my eyes to look at the tail. Then it puffed up its head, conjuring up a menacing cobra. Oh, relief: a Hognose Snake. I hollered to get Erics attention, and we enjoyed watching it for a few minutes. After its initial bluff didnt scare us away, it shape-shifted its head to a triangular form, more reminiscent of the rattlesnake that I had initially feared. It even moved in a sidewinder fashion, a master impressionist. The one trick we didnt get it to do was to play dead. The round pupil is absolute confirmation that this one was nonpoisonous. Certainly a really fascinating creature to have around, though they are predators of toads, ...

Those who need drugs to treat cancer, diabetes and high blood pressure might soon have a reason to thank a snake. Learn more on EarthSky.

There is a good reason why the snake is a symbol for the medical profession in America. - Dr. Naftali Primor.As the world looks to nature to find cures f

Its interesting that you can take something so deadly and turn it into something that has the potential to save lives, said Rice chemist Jeffrey Hartgerink.. Batroxobin is a haemotoxin that has similar properties to thrombin, a naturally occurring enzyme in humans that plays an important role in clotting. First recognised in 1936 for its coagulant capabilities, batroxobin is particularly useful for treating patients who have taken the anti-coagulant drug heparin.. Theres a lot of different things that can trigger blood coagulation, but when youre on heparin, most of them dont work, or they work slowly or poorly, Hartgerink said in a statement.. This is important because surgical bleeding in patients taking heparin can be a serious problem. The use of batroxobin allows us to get around this problem because it can immediately start the clotting process, regardless of whether heparin is there or not.. ...

Addresses: Carredano E, Swedish Univ Agr Sci, Dept Biol Mol, Ctr Biomed, Box 590, S-75124 Uppsala, Sweden. Swedish Univ Agr Sci, Dept Biol Mol, Ctr Biomed, S-75124 Uppsala, Sweden. Univ Uppsala, Ctr Biomed, Dept Biochem, S-75123 Uppsala, Sweden.Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2011-01-14 ...

Genetic analysis of venom allows Indian investigators to determine whether it came from an endangered cobra, helping them to prosecute traffickers.

Antibodies in the antiserum bind the infectious agent or antigen.[8] The immune system then recognizes foreign agents bound to antibodies and triggers a more robust immune response. The use of antiserum is particularly effective against pathogens which are capable of evading the immune system in their unstimulated state but are not robust enough to evade the stimulated immune system. The existence of antibodies to the agent depends on an initial survivor whose immune system, by chance, discovered a counteragent to the pathogen or a host species which carries the pathogen but does not suffer from its effects.[9] Further stocks of antiserum can then be produced from the initial donor or from a donor organism that is inoculated with the pathogen and cured by some stock of pre-existing antiserum. Diluted snake venom is often used as an antiserum to give passive immunity to snake venom itself.[10][11] Horses that were infected by a pathogen were vaccinated thrice in increasing sizes of the dose. The ...

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There have been enough Snake Eyes, Storm Shadow, Cobra Commander and Duke figures that I could cover each variation pretty regularly and still not run out of them for a few more years. In fact, I think thats whats been happening. But what can I do, when those four have been the most ubiquitous characters in GI Joe for the past thirty something years? Hunting through piles of figures, the big four are bound to pop up now and again. So, If you dont like to hear about another Snakes figure, come back tomorrow. Im sure someone different will be in the spotlight. But wait-it might be Duke.. Believe it or not, this black version of the mold was not the first to be released. The man in black was the man in grey and purple for a short time in 2002, a very odd change of pace for the popular ninja. While the greater contrasting colors of that figure brought out the details in the mold, I prefer this black version. I guess my preference goes all the way back to 1982. A perfect Snake Eyes for me would ...

It was about 12.30pm on a Sunday. My kids were in the lounge room, laying about on the couch and watching TV while I prepared their food in the kitchen. Thats when I heard a scream. A moment later Tessa stumbled in and she just sort of dropped onto the ground screaming.

The banded sea snake packs enough poison to kill a human. But to a passing eagle, the snake looks like a tasty-if dangerous-morsel.

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Hashize igihe kinini abafana b’ikipe ya Arsenal binginga Wenger ngo agure rutahizamu mushya wo kunganira Olivier Giroud, ubu ngubu rero birasa naho ibyifuzo byabo byumviswe kuko biravugwako Arsenal igiye kugura Rutahizamu mushya mu masaha make ari imbere.. Nkuko ibinyamakuru byo mu bwongereza bibitangaza ngo ikipe ya Arsenal yaba yamaze kumvikana n’ikipe ya Deportivo La Corogne kuri rutahizamu wayo Lucas Perez w’imyaka 27 y’amavuko.. ...

England appeals to me: Arsenal, Tottenham, Chelsea or Manchester United are nice clubs where I can see myself playing in a few years.. Everywhere I go abroad they know my father, he often asked: Come to Barcelona, Ill give a tour of Camp Nou. I really wanted to go to Barcelona instead of Real Madrid. Barcelona is in my heart, but who am I to say no to Real Madrid?. ...

Arsene Wenger has been at Arsenal so long that Gunners fans feel as if they know him inside out. However, in truth, few fans will ever get to be face-to-face with the Arsenal manager...

Arsenal are reportedly ready to return to their former target Wilfried Zaha, with the winger poised to leave Crystal Palace this summer.

Robin van Persie could return to Arsenal duty against Wigan after injury problems which have seen him play just eight matches this season

Arsene Wenger admits that he has been impressed by West Ham United midfielder Mohamed Diame this season, amid mounting reports Arsenal could swoop for the