Also known as: Obstructive Sleep Apnea (OSAS) / Apnea, Obstructive Sleep / Obstructive Sleep Apnea / Obstructive Sleep Apnea (OSA) / Obstrutive Sleep Apnea / Sleep Obstructive Apnea / Sleep Apnea - Obstructive / Sleep Apnea, Obstructives / Sleep Apnea Obstructive (OSA) / OSA - Obstructive Sleep Apnea / Obstructive Sleep Apnea (SAOS) / Sleep Apnea Syndrome (OSAS) / OSA / OSAS / OSAS (Obstructive Sleep Apneas Syndrome) / Obstructive Sleep Apnea Syndromes / Obstructive Sleep Apnea Syndrome and / Sleep Apnea Syndromes, Obstructive / Obstructive Sleep-Apnea Syndrome / Obstructive Sleep Apnoea Syndrome / Syndrome, Obstructive Sleep Apnea / Obstructive Sleep Apnea Syndrome (OSAS) / Obstructive Sleep Apnea Syndrome / Obstructive sleep apnea hypopnea / Sleep apnea syndrome / Sleep Apnea Syndromes / Sleep apnoea syndromes / Sleep apnea / Sleep apnoea syndrome / Apnea syndrome / Apnoea syndrome / Sleep apnoeas / Sleep apnoea ...

Obstructive sleep apnea is a subtype of sleep disordered breathing. In obstructive sleep apnea, there is a physical obstruction to airflow despite an adequate respiratory drive. The most common symptomatic manifestation of obstructive sleep apnea is snoring. This sleep disorder is characterized by apneas which are abnormally long pauses in breathing during sleep. In addition, abnormally low breathing rates occur and they are termed hypopneas. Obstructive sleep apnea has been associated with the development of several medical diseases including hypertension, coronary artery disease, congestive heart failure, and diabetes. We have recently discussed the finding that sleep disordered breathing is associated with increased risk of developing mild cognitive impairment and dementia. Cardiac arrhythmias have also been shown to be associated with severe obstructive sleep apnea. Researchers led by Dr. Silje K. Namtvedt have shown that even mild obstructive sleep apnea in middle aged individuals is ...

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Title. Obstructive sleep apnoea syndrome - patients perceptions of their sleep and its effects on their life situation Aim. This paper reports a descriptive study of how untreated patients with obstructive sleep apnoea syndrome perceived their sleep situation and how the syndrome affected their life situation. Background. Obstructive sleep apnoea syndrome is a prevalent problem independently associated with an increased risk for hypertension, cardiovascular disease, chronic heart failure and mortality. Increased consumption of healthcare resources can often be seen among patients over a long period of time since many have been undiagnosed and untreated. Methods. A phenomenographic approach was employed. Data were collected by interviews during 2005 with 20 purposively selected participants with untreated obstructive sleep apnoea syndrome. Findings. Participants described loud snoring, frequent awakenings, dyspnoea, frustration over nocturia, fear of dying during sleep and partners anxiety ...

The purpose of this study is to estimate the cost-utility of continuous positive airway pressure (CPAP) therapy in obstructive sleep apnea (OSA) patients in Sao Paulo city, Brazil, after 3 years of treatment and to estimate the cost-effectiveness of CPAP on the number of medical visits, hospitalizations, medical examinations, used medications, new case incidence and cost of traffic accidents and absence from work. It is also designed to estimate quality-adjusted extended years of life, and to assess cost-effects of the therapy (device, masks, supplies, maintenance/year for membership of professional consulting, electric power) on the cost- ...

The etiology and pathogenesis of sleep obstructive apnea hypopnea syndrome (OSAHS) is not yet definitive, evidence shows that the dysfunction of pharyngeal nerve and the atonia of the muscle innervated by these nerve could play an important role in the progress of OSAHS. Dopamine is a neurotransmitter in the central nervous system which significantly affects the sleep-awake regulation. So far mounting evidence shows that dopamine has a potential role in the modulation of hypoglossal nucleus. The progress of dopamine in obstructive sleep apnea hypopnea syndrome is reviewed in this article.

Obstructive sleep apnea hypopnea syndrome (OSAHS) is the most serious among children with sleep disordered breathing. The present study aimed to investigate whether TNF‑α could decrease the glucose transporter type 4 insulin‑responsive (GLUT‑4) expression to promote insulin resistance through the TNF‑α/IKKβ/IKβ/NF‑κB signaling pathway in OSAHS. In total, 30 obese children with OSAHS and 30 non‑OSAHS obese children were enrolled into the present study. TNF‑α expression in adenoid tissues was detected by western blot analysis and immunohistochemistry. The expression of inflammatory factors (IL‑1β, IL‑6 and IFN‑γ) and TNF‑α/IKKβ/IKβ/NF‑κB signaling pathway‑associated proteins was also detected by western blot analysis. The expression of insulin resistance‑associated factors, insulin receptor substrate 1 (IRS1) and GLUT4, was determined by western blot analysis and immunohistochemistry. TNF‑α expression was increased in adenoid tissues of children with ...

Adult Obstructive Sleep Apnea Task Force of the American Academy of Sleep Medicine, Epstein LJ, Kristo D, Strollo PJ Jr, Friedman N, Malhotra A, et al. Clinical guideline for the evaluation, management and long-term care of obstructive sleep apnea in adults. J Clin Sleep Med. 2009 Jun 15;5(3):263-76.. Aurora RN, Casey KR, Kristo D, Auerbach S, Bista SR, Chowdhuri S, et al. Practice parameters for the surgical modifications of the upper airway for obstructive sleep apnea in adults. Sleep. 2010 Oct;33(10):1408-13.. Ballard RD. Management of patients with obstructive sleep apnea. J Fam Pract. 2008 Aug;57(8 Suppl):S24-30.. Barbé F, Durán-Cantolla J, Sánchez-de-la-Torre M, Martínez-Alonso M, Carmona C, Barceló A, et al. Effect of continuous positive airway pressure on the incidence of hypertension and cardiovascular events in nonsleepy patients with obstructive sleep apnea: a randomized controlled trial. JAMA. 2012 May 23;307(20):2161-8.. Basner RC. Continuous positive airway pressure for ...

Metabolic syndrome and cardiovascular disease are strongly associated with obstructive sleep apnea syndrome (OSAS), which causes substantial changes to normal circadian physiological functions, including metabolic pathways. Because core clock genes are known to be modulated by sleep/vigilance cycles, we asked whether the expression level of mRNA coding for clock genes is altered in non-treated OSAS patients and if it can be corrected by standard continuous positive airway pressure (CPAP) treatment ...

Metabolic syndrome and cardiovascular disease are strongly associated with obstructive sleep apnea syndrome (OSAS), which causes substantial changes to normal circadian physiological functions, including metabolic pathways. Because core clock genes are known to be modulated by sleep/vigilance cycles, we asked whether the expression level of mRNA coding for clock genes is altered in non-treated OSAS patients and if it can be corrected by standard continuous positive airway pressure (CPAP) treatment ...

ERNST, Glenda et al. Clinical Characteristics of Patients with Very Severe Obstructive Sleep Apnea. Rev. am. med. respir. [online]. 2019, vol.19, n.3, pp.187-194. ISSN 1852-236X.. Introduction: The presence of obstructive sleep apneas (OSA) is a prevalent disease, whose severity is determined from the Apnea- Hypopnea Index (AHI). Very severe OSA (vsOSA) is defined by an AHI ≥ 60 events/hour; with clinical characteristics that could be different. The purpose of this study was to describe the clinical characteristics of patients with sOSA and compare them with less severe manifestations of this disease. Materials and Methods: Retrospective study of patients referred to a specialized hypertension center who met clinical criteria for the study of OSA. Patients were analyzed by means of a respiratory polygraphy, Ambulatory Monitoring of Arterial Pressure (AMAP), questionnaires and laboratory tests. We used non-parametric tests for the analysis of the results. Results: Of the 115 patients with OSA ...

TY - JOUR. T1 - Impact of obstructive sleep apnea on blood pressure and cardiovascular risk factors in Japanese men. T2 - A cross-sectional study in work-site group. AU - Morinaga, Yuki. AU - Matsumura, Kiyoshi. AU - Kansui, Yasuo. AU - Sakata, Satoko. AU - Goto, Kenichi. AU - Haga, Yoshie. AU - Oishi, Emi. AU - Seki, Takunori. AU - Ohtsubo, Toshio. AU - Kitazono, Takanari. PY - 2018/1/2. Y1 - 2018/1/2. N2 - It has been shown that obstructive sleep apnea (OSA) is related to hypertension and cardiovascular disease; however, the prevalence of OSA in general population and the impact of it on blood pressure especially in Japan has not been well determined. We have conducted a screening test for OSA from 2003 to 2011. In addition, a cross-sectional analysis was performed in 2012 to determine the association of OSA and cardiovascular risk factors in Japanese men (18-69 years of age; mean age, 44.4 ± 0.2). The study group consisted of 2208 male employees, and OSA was evaluated by using the 4% oxygen ...

Respiration 1997; 64(2):159-61. ABSTRACT. We studied the effects of modafinil, a vigilance-enhancing drug, on excessive daytime sleepiness, memory, night sleep and respiration in 6 patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) using a double-blind random cross-over design with 24-hour polysomnography, verbal memory test and a 5-week sleep-wake diary kept by the patients. There were two 2-week treatment periods in which either modafinil or placebo was used; they were separated by a 1-week wash-out period. Our results show that modafinil reduces daytime sleep duration, lengthens the duration of subjective daytime vigilance and improves long-term memory in patients with OSAHS without modifying night sleep and respiration events.. ...

Continuous Positive Airway Pressure machiness simply termed as CPAP machines are used in treating obstructive sleep apnea. It prevents sleep apnea by supplying a steady and constant flow of air pressure through your airway. Sleep apnea can be termed as a condition marked by repeated and brief interruptions in an individuals breathing during sleep. Sleep apnea has many side effects such as drowsiness which reduces your productivity throughout the day. The main objective of a CPAP machine is to eliminate the struggle between sleep and breathing. This enables the machine to correct your breathing patterns throughout the night. Below are the pros of using a CPAP machine in eliminating obstructive sleep apnea.. 1. Minimizes the Risk of Cardiovascular Diseases. Heart disease which is popularly termed as the problem of lungs can be caused by untreated obstructive sleep apnea. Sleep apnea interferes with your breathing pattern which concurrently changes your blood pressure. This will, therefore, cause ...

A 63-year-old feminine with obstructive sleep apnea syndrome (OSAS) presented with clinical features indistinguishable from paradoxical insomnia (PI). the accuracy of the patients perception. Most people suffering from insomnia tend to overestimate sleep onset latency (SOL) and underestimate total buy Bavisant dihydrochloride sleep time (TST)1-4; thus, the reliability of PI as an independent clinical entity has been the subject of much debate.5-8 However, the second edition of the International Classification for Sleep Disorders (ICSD-2) now recognizes PI as a separate disorder and subcategory of insomnia (Table 1).9 Table 1 ICSD-2 diagnostic criteria for paradoxical insomnia The diagnosis of obstructive sleep apnea syndrome (OSAS) is more straightforward. OSAS is characterized by the repeated cessation or a major reduction in upper airway airflow during sleep. It is diagnosed and quantified using the apnea/hypopnea index (AHI), the average number of apnea/hypopnea incidents during an Pax1 hour ...

The No-apnea score vs . the other five questionnaires in screening for obstructive sleep apnea-hypopnea syndrome in patients with cerebral infarction

Obstructive sleep apnea (OSA) is one of the most common sleep disturbances, and it has been estimated that one out of five adults has at least some degree of sleep related breathing disturbances. Obstructive sleep apnea affects mostly the middle-aged work force, and causes a negative impact on public health by increasing both morbidity and mortality. Obesity is related to many diseases including diabetes, cardiovascular diseases, and metabolic syndrome,and obesity is also considered as the most important risk factor for OSA.Considering the prevalence of mild OSA, and the beneficial effects of even a slight weight loss on both the severity of OSA and the likelihood of developing OSA, lifestyle intervention including weight reduction represents a viable option for the treatment of patients with mild OSA.However, although included in the clinical guidelines, there is a definite lack of well executed studies on the effect of weight reduction upon OSA. Accordingly, we are conducting a randomized ...

TY - JOUR. T1 - Missing teeth and pediatric obstructive sleep apnea. AU - Guilleminault, Christian. AU - Abad, Vivien C.. AU - Chiu, Hsiao Yean. AU - Peters, Brandon. AU - Quo, Stacey. PY - 2016. Y1 - 2016. N2 - Background: Missing teeth in early childhood can result in abnormal facial morphology with narrow upper airway. The potential association between dental agenesis or early dental extractions and the presence of obstructive sleep apnea (OSA) was investigated. Methods: We reviewed clinical data, results of polysomnographic sleep studies, and orthodontic imaging studies of children with dental agenesis (n = 32) or early extraction of permanent teeth (n = 11) seen during the past 5 years and compared their findings to those of age-, gender-, and body mass index-matched children with normal teeth development but tonsilloadenoid (T&A) hypertrophy and symptoms of OSA (n = 64). Results: The 31 children with dental agenesis and 11 children with early dental extractions had at least 2 permanent ...

Uvulopalatopharyngoplasty (UPPP) is a widely accepted surgical procedure for the treatment of obstructive sleep apnea/hypopnea syndrome (OSAHS)1 and the only one recommended by the American Sleep Disorders Association. Due to the inaccuracy of current diagnostic methods for preoperatively determining the level of upper airway obstruction in OSAHS patients, as well as the inherent technical limitations of UPPP in dealing the relevant anatomical factors, success rates in attainingobjective cure of about 40% after a long-term follow-up are far from desirable.2 Recent studies, however, have established a staging system that can result in success rates as high as 80% in select patients3 (see Chapter 16: Friedman Tongue Position and the Staging of Obstructive Sleep Apnea/Hypopnea Syndrome). In addition, UPPP is often part of a multilevel treatment strategy, which signifi-cantly improves success rates (see Chapter 17: Multilevel Surgery for Obstructive Sleep Apnea/Hypopnea). In addition to a ...

Title: Obstructive Sleep Apnea Syndrome and Upper Airway Inflammation. VOLUME: 4 ISSUE: 1. Author(s):Hasan M. Inancli and Murat Enoz. Affiliation:Deniz Abdal Mah. Veled Celebi Sok. No: 42 Isyk Apt. A-Blok, Daire: 9, Postal Code: 34092, Findikzade, Istanbul, Turkey.. Keywords:Sleep apnea, inflammation, markers, cytokines, C-reactive protein. Abstract: Obstructive sleep apnea syndrome (OSAS) is associated with inflammatory processes and elevated plasma cytokines. Inflammatory processes associated with OSAS may also act as potential mediators of cardiovascular morbidity in these patients. OSAS is associated with elevated levels of C reactive protein (CRP), as a marker of inflammation and cardiovascular risk. At the inflammatory point of view, the levels of TNF-α, IL-6, hsCRP, adhesion molecules, monocyte chemoattractant protein-1 and resistin were markedly and significantly elevated in patients with sleep apnea than those in normal control subjects. We reviewed several recent patents and ...

Greenberg H, Lakticova V, Scharf SM. Obstructive sleep apnea: clinical features, evaluation, and principles of management. In: Kryger M, Roth T, Dement WC, eds. Principles and Practice of Sleep Medicine. 6th ed. Philadelphia, PA: Elsevier; 2017:chap 114.. Kimoff RJ. Obstructive sleep apnea. In: Broaddus VC, Mason RJ, Ernst JD, et al, eds. Murray and Nadels Textbook of Respiratory Medicine. 6th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 88.. Ng JH, Yow M. Oral appliances in the management of obstructive sleep apnea. Sleep Med Clin. 2019;14(1):109-118. PMID: 30709525 www.ncbi.nlm.nih.gov/pubmed/30709525.. Patil SP, Ayappa IA, Caples SM, Kimoff RJ, Patel SR, Harrod CG. Treatment of adult obstructive sleep apnea with positive airway pressure: an American Academy of Sleep Medicine clinical practice guideline. J Clin Sleep Med. 2019;15(2):335-343. PMID: 30736887 pubmed.ncbi.nlm.nih.gov/30736887.. Redline S. Sleep-disordered breathing and cardiac disease. In: Zipes DP, Libby P, Bonow RO, Mann ...

Obstructive sleep apnea (OSA) is the most common type of sleep apnea and is caused by complete or partial obstructions of the upper airway. It is characterized by repetitive episodes of shallow or paused breathing during sleep, despite the effort to breathe, and is usually associated with a reduction in blood oxygen saturation. These episodes of decreased breathing, called apneas (literally, without breath), typically last 20 to 40 seconds. Individuals with OSA are rarely aware of difficulty breathing, even upon awakening. It is often recognized as a problem by others who observe the individual during episodes or is suspected because of its effects on the body. OSA is commonly accompanied with snoring. Some use the terms obstructive sleep apnea syndrome or obstructive sleep apnea-hypopnea syndrome to refer to OSA which is associated with symptoms during the daytime. Symptoms may be present for years or even decades without identification, during which time the individual may become ...

TY - JOUR. T1 - Computational fluid dynamics endpoints to characterize obstructive sleep apnea syndrome in children. AU - Wootton, David M.. AU - Luo, Haiyan. AU - Persak, Steven C.. AU - Sin, Sanghun. AU - McDonough, Joseph M.. AU - Isasi, Carmen R.. AU - Arens, Raanan. PY - 2014/1/1. Y1 - 2014/1/1. N2 - Computational fluid dynamics (CFD) analysis may quantify the severity of anatomical airway restriction in obstructive sleep apnea syndrome (OSAS) better than anatomical measurements alone. However, optimal CFD model endpoints to characterize or assess OSAS have not been determined. To model upper airway fluid dynamics using CFD and investigate the strength of correlation between various CFD endpoints, anatomical endpoints, and OSAS severity, in obese children with OSAS and controls. CFD models derived from magnetic resonance images were solved at subject-specific peak tidal inspiratory flow; pressure at the choanae was set by nasal resistance. Model endpoints included airway wall minimum ...

Over 22 million Americans suffer from sleep apnea. The causes and intensity of symptoms of sleep apnea vary person to person, so its important to be aware of the treatment options available. Fortunately, Mercy Health has a new treatment for those who suffer from Obstructive Sleep Apnea called the Inspire Therapy.. Medical Director of Sleep Medicine Dr. Christopher Morgan stopped by to explain what sleep apnea is, what symptoms to look out for, and the technology behind new treatment options.. Obstructive sleep apnea is a potentially serious sleep disorder, causing breathing to repeatedly stop and start during sleep. Symptoms include excessive daytime sleepiness, snoring, stopping breathing during sleep, insomnia, excessive nighttime urination, awakening with a dry mouth or sore throat, morning headache, high blood pressure and nighttime sweating.. Patients should treat their sleep apnea so they dont experience daytime fatigue and sleepiness, which can increase the risk for car accidents and ...

TY - JOUR. T1 - Depressive symptomatology in school-aged children with obstructive sleep apnea syndrome. T2 - Incidence, demographic factors, and changes following a randomized controlled trial of adenotonsillectomy. AU - Hodges, Elise. AU - Marcus, Carole L.. AU - Kim, Ji Young. AU - Xanthopoulos, Melissa. AU - Shults, Justine. AU - Giordani, Bruno. AU - Beebe, Dean W.. AU - Rosen, Carol L.. AU - Chervin, Ronald D.. AU - Mitchell, Ron B.. AU - Katz, Eliot S.. AU - Gozal, David. AU - Redline, Susan. AU - Elden, Lisa. AU - Arens, Raanan. AU - Moore, Renee. AU - Taylor, H. Gerry. AU - Radcliffe, Jerilynn. AU - Thomas, Nina H.. PY - 2018/12/1. Y1 - 2018/12/1. N2 - Study Objectives Depressive symptoms following adenotonsillectomy (AT) relative to controls were examined in children with obstructive sleep apnea syndrome (OSAS). Methods The Childhood Adenotonsillectomy Trial (CHAT) multisite study examined the impact of AT in 453 children aged 5 to 9.9 years with polysomnographic evidence of OSAS ...

Obstructive sleep apnea is a significant medical problem affecting up to 4 percent of middle-aged adults. The most common complaints are loud snoring, disrupted sleep and excessive daytime sleepiness. Patients with apnea suffer from fragmented sleep and may develop cardiovascular abnormalities because of the repetitive cycles of snoring, airway collapse and arousal. Although most patients are overweight and have a short, thick neck, some are of normal weight but have a small, receding jaw. Because many patients are not aware of their heavy snoring and nocturnal arousals, obstructive sleep apnea may remain undiagnosed; therefore, it is helpful to question the bedroom partner of a patient with chronic sleepiness and fatigue. Polysomnography in a sleep laboratory is the gold standard for confirming the diagnosis of obstructive sleep apnea; however, the test is expensive and not widely available. Home sleep studies are less costly but not as diagnostically accurate. Treatments include weight loss, nasal

Obstructive sleep apnea (OSA) is the most common category of sleep-disordered breathing. The muscle tone of the body ordinarily relaxes during sleep, and at the level of the throat the human airway is composed of collapsible walls of soft tissue which can obstruct breathing during sleep. Mild occasional sleep apnea, such as many people experience during an upper respiratory infection, may not be important, but chronic severe obstructive sleep apnea requires treatment to prevent low blood oxygen (hypoxemia), sleep deprivation, and other complications. The most serious complication is a severe form of congestive heart failure called cor pulmonale.[citation needed]. Individuals with low muscle tone and soft tissue around the airway (e.g., because of obesity) and structural features that give rise to a narrowed airway are at high risk for obstructive sleep apnea. The elderly are more likely to have OSA than young people. Men are more likely to suffer sleep apnea than women and children are, though ...

Obstructive sleep apnea hypopnea The pathophysiology of obstructive sleep apnea syndrome (OSAS) is poorly understood. Alterations exist in alveolar ventilation and oxygenation. OSAS is associated wit... more

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Lifestyle modification, particularly weight loss, has been advocated as a treatment modality for obstructive sleep apnoea syndrome (OSAS). Surprisingly, there is a lack of well-conducted clinical trials; available studies have either been small and/or non-randomised. One reason could be that it has become popular to use devices such as continuous positive airway pressure (CPAP) or mandible retraction devices as mechanical tools rather than try to address the underlying problem, which generally is excess fatness in the throat area. In a report, from the International Diabetes Federation investigating the association between type 2 diabetes and sleep- disordered breathing, a number of recommendations were given. Apart from increased awareness and improved clinical practice the working party strongly suggested appropriately powered randomised control trials of weight loss in patients with OSAS and diabetes, including the use of anti-obesity medication. The party also suggest the development of ...

Authors: Wardly DE.. Obstructive sleep apnea has been shown to increase intracranial pressure, and to be a secondary cause of intracranial hypertension. There are a few theories that attempt to explain this relationship, however there is little data, and even less recognition among physicians that this actually occurs. This paper discusses multiple pieces of data, from anatomical correlates to biochemical information involving neuro-excitotoxicity, as well as hematologic factors and issues surrounding brain edema and blood-brain barrier dysfunction. A complex paradigm for how obstructive sleep apnea may lead to increased intracranial pressure is thus proposed. In addition, suggestions are made for how obstructive sleep apnea must as a result be managed differently in the setting of idiopathic intracranial hypertension.. ...

During your school days, you may remember reading about Joe the fat boy from the Pickwick papers written by Charles Dickens in 1837.. Joe ate in great quantities and was liable to fall asleep during any situation. His breathing was heavy, he snored and he was continuously sleepy. Originally described as the Pickwickian syndrome, his breathing was later labelled as obstructive sleep apnoea syndrome.. While obstructive sleep apnoea more often affects men with a neck size of 17 inches or larger, it can also affect children and adults who are not overweight. Children who breathe through their mouth are at risk of developing cranio-facial changes, such as undeveloped jaws, smaller airways, and narrow faces. It also increases the likelihood of the child developing lifelong sleep apnoea.. Obstructive sleep apnoea is the most common type of apnoea and is characterised by holding the breath from collapse of the upper airways during sleep. This holding of the breath, which prevents airflow to the lungs, ...

Continuous positive airways pressure (CPAP) is the most common treatment for obstructive sleep apnoea. It involves the use of a pump which delivers low pressure air into the airways via tubing and a mask fitted to the nose. It is worn during sleep and delivers enough pressure to keep the airway open during sleep. The amount of pressure required to maintain an open airway varies with each individual. If the results of the sleep study clearly indicate OSA, a CPAP machine is often applied and adjusted to the appropriate settings while the study is in progress. It may be necessary to return to the sleep clinic after the study to receive training on how to properly use the CPAP machine at home. Many people find they feel much better within a few days of commencing CPAP as they get the benefit of deep restorative sleep that they previously lacked.. Variations of positive airways pressure therapy devices are auto-titrating CPAP, in which the levels of pressure are adjusted if the device senses ...

The Federal Motor Carrier Safety Administration (FMCSA) and the Federal Railroad Administration (FRA) withdraw the March 10, 2016, advance notice of proposed rulemaking concerning the prevalence of moderate-to-severe obstructive sleep apnea (OSA) among individuals occupying safety sensitive positions in highway and rail transportation, and its potential consequences for the safety of highway and rail transportation.

Sleep disordered breathing represents a continuum, ranging from simple snoring sans sleepiness, upper‑airway resistance syndrome, obstructive sleep apnea (OSA) syndrome, to hypercapnic respiratory failure. Fifty seven articles formed the initial database and a final total of 50 articles were selected to form this review report. Four months were spent on the collection and retrieval of the articles. Articles were selected based on accuracy and evidence in the scientific literature. Oral appliances (OAs) are indicated for use in patients with mild to moderate OSA who prefer them to continuous positive airway pressure (CPAP) therapy, or for those who do not respond to, are not appropriate candidates for, or for those who have failed treatment attempts with CPAP. OAs protrude the mandible and hold it in a forward and downward position. As a consequence, the upper airway enlarges antero‑posteriorly and laterally, improving its stability. Although OA are effective in some patients with OSA, they ...

Exosomal microRNAs (miRNAs) have attracted increasing interest as biomarkers for the diagnosis of numerous human diseases; however, little is known about exosomal miRNAs in regard to pediatric obstructive sleep apnea syndrome (OSAS). The aim of this study was to identify exosomal miRNAs involved in OSAS and to determine their relative functions. Serum exosomal miRNA-expression patterns in pediatric OSAS patients and healthy donors were analyzed comprehensively via RNA sequencing, and differently expressed miRNAs were verified using quantitative reverse transcription polymerase chain reaction. The effect of the miRNAs on cell culture was measured by flow cytometry. Results revealed that 364 and 464 miRNAs were identified in normal and OSAS exosomes, respectively. Moreover, exosomal miR-664a-3p, miR-210, miR-21-3p, and miR-107 were significantly more downregulated in exosomes from OSAS than in those of healthy controls. These downregulated miRNAs were mainly involved in functions involving cell ...

1. Problems in the airway. Obstructive sleep apnea results from an obstruction in the airway, which is usually caused by certain problems in the airway components. These include the upper and lower jaws, tonsils, soft palate, tongue, and throat muscles. Some sleep apnea cases involve over-relaxed throat muscles and tongue. When a person sleeps, his muscles normally relax, but when his throat muscles and tongue relax more than normal, it results in narrowing of the airway and causes apneic events. Enlarged and collapsed soft palate and tonsils also cause obstructive sleep apnea. 2. Structural abnormalities. Anatomical abnormalities contribute to a persons tendency to experiencing obstructive sleep apnea. For instance, the bone structure and shape of the head and neck may affect the size of the airway. A thicker neck may mean narrower airway. Moreover, large tongue and tonsils may also have an effect on the air passage. There are also structural abnormalities in the jaw, nose, and mouth that ...

This study investigate the impact of anti hypertensive drugs in obstructive sleep apnea patients, i.e., whether or not obstructive sleep apnea may constitute

Continuous positive airway pressure (CPAP) is the most effective treatment for obstructive sleep apnea. CPAP involves wearing a mask that props open the airway and circulates air pressure during the night. Improvements have been shown across diverse sleep conditions (e.g., sleeping while watching an event, restless sleep) and quality of life measures after six months of CPAP treatment. Improvements in quality of life include in daily in functioning, social interactions, and emotional functioning. In addition, a lower incidence of hypertension was found in persons who were treated with continuous positive airway pressure (CPAP) (Marin et al., 2012). Treatments should last for at least 6 months. Below a treatment threshold, which may be longer for some patients, sleep apnea symptoms can return when treatment is stopped. Cranial facial structure abnormalities can require surgery. Participants in a survey of maxillomandibular advancement (MMA) over 53 studies, or 627 adults, reported improvements in ...

Generally, poor sleep leads to lower pain thresholds and a lower pain threshold decreases sleep efficiency. Obstructive sleep apnea not only disrupts sleep but does so with repeated bursts of stress hormones and a drop in blood oxygen which can be quite significant.. Studies have shown a 55.4% prevalence of chronic widespread pain in patients with obstructive sleep apnea and a greater risk of chronic pain in female than in male patients. Female patients with obstructive sleep apnea and chronic pain have higher pain and disability levels and a lower quality of life. This seems in general agreement with anecdotal evidence.. So pain and sleep loss may contribute to one another. Experiencing chronic pain can lead to sleep deprivation, but sleep deprivation can also make pain symptoms worse. It becomes a chicken and egg situation where it may be difficult to determine which is causing which - most medical issues have a bi-directional component, simply put, both will influence the other to a degree. ...

Bibliographic Source(s). Epstein LJ, Kristo D, Strollo PJ Jr, Friedman N, Malhotra A, Patil SP, Ramar K, Rogers R, Schwab RJ, Weaver EM,. Weinstein MD, Adult Obstructive Sleep Apnea Task Force of the American Academy of Sleep Medicine. Clinical guideline. for the evaluation, management and long-term care of obstructive sleep apnea in adults. J Clin Sleep Med 2009 Jun. 15;5(3):263-76. PubMed. Guideline Status. This is the current release of the guideline.. Scope. Disease/Condition(s). Obstructive sleep apnea (OSA). Guideline Category. Counseling. Diagnosis. Evaluation. Management. Risk Assessment. Treatment. Clinical Specialty. Dentistry. Family Practice. Geriatrics. Internal Medicine. Otolaryngology. Pulmonary Medicine. Sleep Medicine. Surgery. Intended Users. Advanced Practice Nurses. Dentists. Health Care Providers. Physician Assistants. Physicians. Respiratory Care Practitioners. Guideline Objective(s). To assist primary care providers as well as sleep medicine specialists, surgeons, and ...

Obstructive sleep apnea is the most common type of sleep apnea, caused by blockage of the upper airway. People with obstructive sleep apnea often repo

Title: Obstructive Sleep Apnea and Obesity. VOLUME: 4 ISSUE: 2. Author(s):Shyam Subramanian and Kingman Strohl. Affiliation:Center for Sleep Disorders Research, Louis Stokes VA Medical Center, 111j(w), 10701 East Boulevard,Cleveland, OH 44106, USA.. Abstract: Obesity trends continue to rise in alarming proportions worldwide. Obstructive sleep apnea, an increasingly commonly recognized disorder, is characterized by recurrent episodes of upper airway closure during sleep, and obesity is proposed to be its strongest risk factor. Recognition strategies for OSA in obesity are overwhelmed by the sheer prevalence of obstructive sleep apnea, > 80% in those with a BMI > 40. Obesity has direct as well as indirect influences on upper airway mechanics and physiology. Obesity may also influence loop gain by exerting an influence on central chemosensory respiratory drive. Pattern of fat distribution rather than overall weight may have a modulatory effect on these influences. Obese patients also develop a ...

There are patterns of unusual facial features that occur in recognizable syndromes. Some of these craniofacial syndromes are genetic, others are from unknown causes. In many craniofacial syndromes, the features that are unusual involve the nose, mouth, and jaw, or resting muscle tone, and put the individual at risk for OSA syndrome. Down syndrome is one such syndrome. In this chromosomal abnormality, several features combine to make the presence of obstructive sleep apnea more likely. The specific features of Down syndrome that predispose to obstructive sleep apnea include relatively low muscle tone, narrow nasopharynx, and large tongue. Obesity and enlarged tonsils and adenoids, conditions that occur commonly in the western population, are much more likely to be obstructive in a person with these features than without them. Obstructive sleep apnea does occur even more frequently in people with Down syndrome than in the general population. A little over 50% of all people with Down syndrome ...

If these measures dont improve your sleep or if your apnea is moderate to severe, then your doctor may recommend other treatments. Certain devices can help open up a blocked airway. In other cases, surgery may be necessary.. Therapies: Positive airway pressure. If you have obstructive sleep apnea, you may benefit from positive airway pressure. In this treatment, a machine delivers air pressure through a piece that fits into the nose or is placed over the nose and mouth while you sleep. Positive airway pressure reduces the number of respiratory events that occur as you sleep, reduces daytime sleepiness and improves your quality of life.. The most common type is called continuous positive airway pressure, or CPAP (SEE-pap). With this treatment, the pressure of the air breathed is continuous, constant and somewhat greater than that of the surrounding air, which is just enough to keep your upper airway passages open. This air pressure prevents obstructive sleep apnea and snoring.. CPAP may be given ...

Obstructive sleep apnea predicts adverse perioperative outcome: evidence for an association between obstructive sleep apnea and delirium

Background and Objective: Continuous positive airway pressure (CPAP) is a standard therapy for patients with moderate to severe obstructive sleep apnea (OSA). Increased demands for polysomnography (PSG) and CPAP titration have led to long waiting lists and high cost. CPAP prediction formulas derived from sleep and anthropometric parameters are used to set the initial CPAP level during CPAP titration. In the current study, we aimed to compare the pressure derived from prediction formulas with the pressure resulted from CPAP titration in a sample of Iranian patients.. Materials and Methods: In this cross-sectional study, 90 subjects with confirmed OSA in a full PSG who underwent CPAP titration in Baharloo Sleep Clinic, Tehran, Iran, during 2017, were enrolled. All of the participants had Respiratory Disturbance Index (RDI) ≥ 15 in their PSG test. Then, the optimal pressure obtained from manual CPAP titration was compared with the one calculated by different prediction formulas for each ...

Obstructive sleep apnea is a relatively common disorder that can lead to lost productivity and cardiovascular disease. The form of positive airway treatment that should be offered is unclear. MEDLINE and the Cochrane Central Trials registry were searched for English language randomized controlled trials comparing auto-titrating positive airway pressure (APAP) with continuous positive airway pressure (CPAP) in adults with obstructive sleep apnea (inception through 9/2010). Six researchers extracted information on study design, potential bias, patient characteristics, interventions and outcomes. Data for each study were extracted by one reviewer and confirmed by another. Random effects model meta-analyses were performed for selected outcomes. Twenty-four randomized controlled trials met the inclusion criteria. In individual studies, APAP and fixed CPAP resulted in similar changes from baseline in the apnea-hypopnea index, most other sleep study measures and quality of life. By meta-analysis, APAP improved

Study objective: To evaluate the tolerability and to find predictors of treatment success for an individually adjusted, one-piece mandibular advancement device in patients with snoring and obstructive sleep apnea.. Design: Prospective study.. Setting: Departments of Respiratory Medicine and Orthodontics, Umeå University.. Patients: Six hundred nineteen of 630 patients (98%), who consecutively received treatment for sleep apnea and snoring from February 1989 to August 2000, were followed up. They had a mean apnea-hypopnea index of 16 (range, 0.0 to 76) and a mean body mass index of 28 (range, 19 to 42).. Measurements: Interviews, questionnaires, and overnight sleep apne a recordings. Patients with an apnea-hypopnea index of ≥10 in the supine and/or lateral position were considered to have obstructive sleep apnea. A lateral apnea-hypopnea index of , 10, together with a supine apnea-hypopnea index of ≥ 10, defined supine-dependent sleep apneas.. Results: One hundred forty-eight of the 619 ...

Continuous positive airway pressure therapy ( CPAP ) uses a machine to help a person who has obstructive sleep apnea (OSA) breathe more easily during sleep. A CPAP machine increases air pressure in your throat so that your airway doesnt collapse when you breathe in. When you use CPAP, your bed partner may sleep better...

Introduction To evaluate the impact of continuous positive airway pressure (CPAP) therapy on overactive bladder (OAB) symptoms in women with obstructive sleep apnea syndrome (OSAS). Material and methods One-hundred and fifty women underwent an overnight polysomnography study between May 2014 and September 2014. Their voiding symptoms were evaluated using the OAB symptom score (OABSS) and International Consultation on Incontinence Questionnaire Short-Form at OSAS diagnosis and approximately 3-months after CPAP therapy. OSAS severity was assessed according to the apnea-hypopnea-index. Results We evaluated 140 women and 111 of them (79.3%) reported symptoms consistent with OAB. There were no statistically significant differences between OSAS severity with a prevalence of OAB (p = 0.92). The prevalence of urinary incontinence (UI) was 35.7% (n = 50) and 39.6% (n = 44) in all patients and patients with OAB, respectively. There were no statistically significant differences between UI with OAB (p = ...

BACKGROUND--Patients with the sleep apnoea/hypopnoea syndrome often receive continuous positive airway pressure to improve their symptoms and daytime performance, yet objective evidence of the effect of this treatment on cognitive performance is lacking. METHODS--A prospective parallel group study was performed comparing the change in objective daytime sleepiness as assessed by multiple sleep latency, cognitive function, and mood in 21 patients (mean (SE) number of apnoeas and hypopnoeas/hour 57 (6)) who received continuous positive airway pressure for three months and 16 patients (49(6) apnoeas and hypopnoeas/hour) who received conservative treatment for a similar period. RESULTS--Both groups showed significant within group changes in cognitive function between baseline and three months, but when comparisons were made between groups the only significant difference was a greater improvement in multiple sleep latency with continuous positive airway pressure. However, the improvement in sleep ...

Obstructive sleep apnea (OSA) is characterized by recurrent periods of upper airway obstruction (hypopneas and apneas) during sleep. It leads to repeated oxyhemoglobin desaturations, nocturnal hypercapnia, and arousals. Common symptoms include loud snoring with breathing interruptions. Excessive daytime sleepiness and cognitive impairment occur. Obstructive sleep apnea is a major cause of morbidity and mortality in Western society. Its association with an increased risk of development and progression of neurocognitive, metabolic, cardiovascular and oncologic diseases and complications is well described. The significant factor in OSA pathogenesis is reduced muscle tone in the tongue and upper airway. In the recent years, devices providing neurostimulation of the hypoglossal nerve (HGNS) were developed as an alternative for noncompliant CPAP (continuous positive airway pressure) patients. Clinical trials suggest that electrical stimulation of the hypoglossal nerve is effective. This is considered ...

Obstructive sleep apnea is an expected competency for Otolaryngology - Head and Neck surgery residents and tested on the Royal College of Physicians and Surgeons examination. Our objective was to evaluate the knowledge, attitudes and confidence of Canadian Otolaryngology - Head and Neck surgery residents in managing Obstructive Sleep Apnea (OSA) patients. An anonymous, online, cross-sectional survey was distributed to all current Canadian Otolaryngology-Head and Neck surgery residents according to the Dillman Tailored Design Method in English and French. The previously validated OSA Knowledge and Attitudes (OSAKA) questionnaire was administered, along with questions exploring resident confidence levels with performing OSA surgeries. Descriptive statistics, Wilcoxon Rank Sum and unpaired Students t tests were calculated in Excel. Sixty-six (38.4%) out of 172 residents responded (60.6% male; 80.3% English-speaking). Median OSAKA knowledge score was 16/18 (88.9%; Interquartile range: 14-16). Although all

Purpose: : To study retinal nerve fiber layer (RNFL) thickness in patients with obstructive sleep apnea syndrome (OSAS). Methods: : 120 patients with OSAS were analyzed and compared with an age-matched control group of 104 subjects. Patients with OSAS underwent sleep studies to determine the respiratory disturbance index (RDI) during night sleep and were classified as having moderate (RDI, 20-39) or severe (RDI , 40) sleep apnea. The RNFL thickness was assessed by optical coherence tomography (StratusOCT) using the fast RNFL thickness (3.4) scan acquisition protocol. Results: : Compared with the control group, eyes with OSAS showed a thinner RNFL in the 360 degrees average measurement (101.52+/-11.3µ, 101.38+/-11.3µ for control right eye and left eye respectively and 97.86+/-12.03µ, 96.5+/-12.13µ for OSAS in the right eye and left eye respectively, p=0.02) and in the superior (p=0.034) and inferior (p=0.03) quadrants in the right eye and superior (p=0.03) and temporal (p=0.02) quadrants in ...

CPAP treatment was associated with a reduction in the number of patients with unsustained AT (from 8 to 1, P=.024) and in the total number of AT beats (P=.026). In contrast, the number of VEs did not fall significantly (P=.44).. Two patients developed episodes of second-degree atrioventricular block. The use of CPAP in both patients resolved conduction changes and neither required pacemaker implantation. Two more patients had non-severe sinus dysfunction, which resolved in 1 of them after introduction of CPAP; neither required a pacemaker.. Subgroup Analysis. Patients over 50 years of age (n=17) had more disturbed baseline HRV figures than younger patients (P,.05) and their frequency domain parameters (VLF, LF and HF) during waking hours improved more significantly than the under-50 age group (P,.05). Age did not affect the incidence of arrhythmias, nor the influence of CPAP on this parameter. Arterial hypertension was more common in patients aged,50 years (14/17 vs. 3/9 patients, P=.03), and ...

- CENTRAL SLEEP APNEA VS OBSTRUCTIVE SLEEP APNEA - Central Sleep Apnea and Obstructive Sleep Apnea are both forms of this sleeping condition READ MORE...

According to your dentist in Orange County, people who have severe sleep apnea may not see great results with oral appliance therapy. Your primary care physician and a sleep specialist will be able to determine the severity of your obstructive sleep apnea.. If your obstructive sleep apnea is mild to moderate, there are different brands and styles of oral appliances. While some are designed for snoring, others are actually made to improve breathing and keep your passages open. The TAP or Thornton Adjustable Positioner Device along with the Herbst oral appliance improves airway patency.. Some custom made oral appliances enlarge your airways while preventing airway collapse. These types of appliances cover the lower and upper teeth while holding your lower jaw in a forward position.. ...

COVID-19 Impact is propelling the demand for continuous positive airway pressure (CPAP) devices. With an increase in cases of COVID-19 across the globe, there is a requirement for effective management of the infection using CPAP therapy. A shortage of ventilators during the COVID-19 pandemic has forced healthcare professionals to select alternative methods to deliver respiratory support to patients. Some of the modifications are required to convert CPAP devices to treat respiratory insufficiency, which helps to minimize aerosolization.. On the other hand, the high cost of device and maintenance along with high costs treatments are expected to limit the growth of global continuous positive airway pressure (CPAP) devices market. Also, infrastructural developments in the medical and healthcare industry in the field of continuous positive airway pressure (CPAP) devices market for sleep apnea treatment are expected to generate more opportunities for key players operating in the market.. Global ...

The team at Long Island Dental Sleep Medicine is at the vanguard of dental offices combating the dangers associated with obstructive sleep apnea.

IMPORTANCE: Oral appliances that move the mandible forward during sleep are suggested as treatment for mild to moderate obstructive sleep apnea.. OBJECTIVE: To test whether an adjustable, custom-made oral appliance improves daytime sleepiness and quality of life in patients with daytime sleepiness and snoring or mild to moderate obstructive sleep apnea.. DESIGN, SETTING, AND PARTICIPANTS: Ninety-six patients with daytime sleepiness and an apnea-hypopnea index (AHI) lower than 30 were included in a randomized, placebo-controlled, parallel trial in Umeå, Sweden, from May 2007 through August 2011.. INTERVENTIONS: Four months intervention with an oral appliance or a placebo device.. MAIN OUTCOMES AND MEASURES: Daytime sleepiness was measured with the Epworth Sleepiness Scale, the Karolinska Sleepiness Scale, and the Oxford Sleep Resistance (OSLER) test. Quality of life was assessed with the Short-Form 36-Item Health Survey (SF-36) and the Functional Outcomes of Sleep Questionnaire (FOSQ). ...

Innovative treatments for adults with obstructive sleep apnea Terri E Weaver,1,2 Michael W Calik,1,2 Sarah S Farabi,1,2 Anne M Fink,1,2 Maria T Galang-Boquiren,2,3 Mary C Kapella,1,2 Bharati Prasad,2,4 David W Carley1,21Biobehavioral Health Science Department, College of Nursing, University of Illinois at Chicago; 2Center for Narcolepsy, Sleep and Health, University of Illinois at Chicago College of Nursing, 3Department of Orthodontics, University of Illinois at Chicago College of Dentistry, 4Sleep Center, Department of Medicine, University of Illinois at Chicago College of Medicine, Chicago, IL, USAAbstract: Obstructive sleep apnea (OSA) affects one in five adult males and is associated with significant comorbidity, cognitive impairment, excessive daytime sleepiness, and reduced quality of life. For over 25 years, the primary treatment has been continuous positive airway pressure, which introduces a column of air that serves as a pneumatic splint for the upper airway, preventing the airway collapse

TY - JOUR. T1 - Poor sleep quality and obstructive sleep apnea in patients with GERD and Barretts esophagus. AU - Vela, M. F.. AU - Kramer, J. R.. AU - Richardson, P. A.. AU - Dodge, R.. AU - El-Serag, H. B.. PY - 2014/3/1. Y1 - 2014/3/1. N2 - Background: Gastroesophageal reflux disease (GERD) reduces sleep quality. Whether Barretts esophagus (BE) affects sleep differently is unknown. Obstructive sleep apnea (OSA) often coexists with GERD and may disrupt sleep; whether GERD reduces sleep quality independently of OSA is unknown. Our aims were to compare the effect of GERD and BE on sleep quality, and assess the impact of OSA on this association. Methods: Validated questionnaires for GERD symptoms, sleep quality, and OSA risk were prospectively administered to subjects undergoing upper endoscopy. GERD was defined by erosive esophagitis and/or reflux symptoms ,1/week. BE was defined histologically. Controls had normal endoscopy and were asymptomatic. Poor sleep quality was defined by a Pittsburgh ...

Obstructive sleep apnea syndrome (OSAS) is a common sleep related breathing disorder. Its prevalence is estimated to be between 2% and 25% in the general population. However, the prevalence of sleep apnea is much higher in patients undergoing elective surgery. Sedation and anesthesia have been shown …

Background: Previous studies showed that obstructive sleep apnea (OSA) is common in patients with heart failure (HF) and associated with poor cardiovascular outcomes. However, therapeutic impact of continuous positive airway pressure (CPAP) on mortality and morbidity remains unclear among patients with HF.. Methods: In a prospective cohort study, we examined 111 HF patients who underwent sleep study, and compared all-cause death and HF hospitalization rates among patients without OSA, those with untreated OSA (apnea-hypopnea index ≥ 10 per hr of sleep), and those with OSA treated by CPAP.. Results: Patients were divided into without OSA (N=32), untreated OSA (N=53) and treated OSA (N=26). During a median follow-up of 21±9 months, there was no death in those with treated OSA, while there was no significant difference in total death rate between those without OSA and with untreated OSA (log-rank test P=0.558). However, there were 52 (28%) all-cause deaths plus HF hospitalizations during ...

Obstructive Sleep Apnea Syndrome (OSA). Otolaryngology: Diagnostic in Hannover, Germany ✈. Prices on BookingHealth.com - booking treatment online!

Obstructive Sleep Apnea Syndrome (OSA). Otolaryngology: Diagnostic in Jena, Germany ✈. Prices on BookingHealth.com - booking treatment online!

Pediatric obstructive sleep apnea/hypopnea syndrome (OSAHS) is a multifactorial syndrome caused by many risk factors, such as craniofacial anomalies, adenotonsillar hypertrophy, obesity, and airway inflammation. Although new treatment patterns have recently been proposed, treatment methods for children remain particularly challenging and controversial. This randomized controlled trial was designed to investigate the efficacy of adenotonsillectomy and/or orthodontic treatment for children who have mild OSAHS with mandibular retrognathia. A sample of 352 children with mild OSAHS and mandibular retrognathia, who are aged between 7 and 10 years, will be enrolled in the study. They will be randomized into four groups: the drug treatment group, the surgical treatment group, the orthodontic treatment group, or the surgery and postoperative orthodontic group. After randomization the children will receive treatments within 4 weeks. Outcome assessment will take place at the following points: (1) baseline, (2) 7

Auto-titrating continuous positive airway pressure treatment for obstructive sleep apnoea after acute quadriplegia (COSAQ): study protocol for a randomized controlled trial. Berlowitz, David J.; Ayas, Najib; Barnes, Maree; Brown, Douglas J.; Cistulli, Peter A.; Geraghty, Tim; Graham, Alison; Lee, Bonsan Bonne; Morris, Meg; ODonoghue, Fergal; Rochford, Peter D.; Ross, Jack; Singhal, Balraj; Spong, Jo; Wadsworth, Brooke; Pierce, Robert J. // Trials;2013, Vol. 14 Issue 1, p1 Background: Quadriplegia is a severe, catastrophic injury that predominantly affects people early in life, resulting in lifelong physical disability. Obstructive sleep apnoea is a direct consequence of quadriplegia and is associated with neurocognitive deficits, sleepiness and reduced quality of... ...

Effect of continuous positive airway pressure on endothelial function in patients with obstructive sleep apnea: a meta-regression analysis. Abstract. Objective: Obstructive sleep apnea (OSA) is related to the occurrence of endothelial dysfunction. Continuous positive airway pressure (CPAP) is the gold standard treatment for OSA.

RESULTS: Success rate was 93.3%. There was a statistically significant amelioration of Apnea-Hypopnea Index (AHI), supine AHI, Oxygen Desaturation Index (ODI), and ESS score. The Müller test demonstrated a quite homogeneous distribution of oropharyngeal and hypopharyngeal obstruction. At DISE without mandibular pull-up maneuver, a predominant complete oropharyngeal and hypopharyngeal collapse was observed. The execution of mandibular pull-up maneuver showed a notable reduction in pharyngeal collapsibility. In particular, hypopharyngeal/retrolingual collapse zeroed in 93% of cases ...

It might seem strange to think about - but the answer is yes.. First of all, central sleep apnea isnt generally associated with snoring to begin with. This type of apnea has to do with the brain signals themselves - not with an obstruction in the throat. And though it is less common, it certainly isnt unheard of.. In fact, with obstructive sleep apnea, the chest will still rise and fall, as if breathing is taking place - despite the fact that no air is entering or leaving the airway.. But with central sleep apnea, the chest doesnt even rise up and down.. Now, obstructive sleep apnea is a bit different. OSA is almost always accompanied by snoring - but that doesnt mean that it always is.. According to Dr. Robert L. Owens of the Sleep Disorders Research Program at Brigham and Womens Hospital in Boston:. Most people who snore dont have obstructive sleep apnea, but most people who have apnea snore…. So, it is possible to suffer from obstructive sleep apnea without snoring - but it is ...

TY - JOUR. T1 - Obstructive sleep apnea increases the risk of bladder pain syndrome/interstitial cystitis. T2 - A population-based matched-cohort study. AU - Chung, Shiu Dong. AU - Lin, Ching Chun. AU - Liu, Shih Ping. AU - Lin, Herng Ching. PY - 2014. Y1 - 2014. N2 - Aims: Previous studies indicated a possible association between bladder pain syndrome/interstitial cystitis (BPS/IC) and sleep disorders including sleep abnormalities with delayed onset of sleep, waking up before needed, and snoring. Nevertheless, no previous study has reported the association between obstructive sleep apnea (OSA) and BPS/IC. In this retrospective cohort study, we examined the risk of BPS/IC among subjects with OSA during a 3-year follow-up in Taiwan using a population-based dataset. Methods: This study comprised 2,940 study subjects with OSA, and 29,400 randomly selected comparison subjects. We individually followed-up each sampled subject (n = 32,340) for a 3-year period to identify those subjects who ...

TY - JOUR. T1 - Electrical stimulation of the lingual musculature in obstructive sleep apnea. AU - Schwartz, Alan R.. AU - Eisele, David W.. AU - Hari, Anil. AU - Testerman, Roy. AU - Erickson, Donald. AU - Smith, Philip L.. N1 - Copyright: Copyright 2018 Elsevier B.V., All rights reserved.. PY - 1996/8. Y1 - 1996/8. N2 - The influence of lingual muscle activity on airflow dynamics in the upper airway was examined in nine patients with obstructive sleep apnea. Muscles that retract the tongue (hyoglossus and styloglossus) and protrude the tongue (genioglossus) were selectively stimulated electrically during sleep with fine wire electrodes placed intramuscularly transorally. We confirmed that stimulation with 50 Hz and 40-μs pulse duration did not elicit changes in electroencephalographic patterns or heart rate or alter airflow after the stimulation burst had ceased. The highest stimulus intensity that did not arouse patients from sleep was then utilized to examine the effect of lingual muscle ...

1. Benjafield A, Valentine K, Ayas N, et al. Global prevalence of obstructive sleep apnea in adults: estimation using currently available data. American Journal of Respiratory and Critical Care Medicine.2018; 197:A3962.. 2. Heinzer R, Vat S, Marques-Vidal P, et al. Prevalence of sleep-disordered breathing in the general population: the HypnoLaus study. Lancet Respir Med. 2015;3(4):310-318.. 3. American Dental Association. Proposed policy statement on the role of dentistry in the treatment of sleep-related breathing disorders. American Dental Association Website. http://www.ada.org/~/media/ADA/Member%20Center/FIles/Role_of_Dentistry_in_the_Treatment_of_Sleep_1-5.pdf?la=en. Accessed November 21, 2018.. 4. Gray EL, McKenzie DK, Eckert DJ. Obstructive sleep apnea without obesity is common and difficult to treat: evidence for a distinct pathophysiological phenotype. J Clin Sleep Med. 2017;13(1):81-88.. 5. Eckert DJ. Phenotypic approaches to obstructive sleep apnoea - New pathways for targeted ...

Our study demonstrated that zaleplon administered just before CPAP titration during split-night PSG improved initial sleep latency without affecting minimum oxygen saturation or resultant CPAP pressure. Contrary to our hypothesis, use of zaleplon did not result improvement in sleep efficiency or arousal indices, and thus perception of sleep quality during the PSG did not differ between the two groups. Although CPAP adherence was relatively high in both groups, use of zaleplon did not result in increased compliance. Improvements in OSA-related symptoms as measured by FOSQ and ESS were also similar in the zaleplon and placebo groups.. Our data conflict with Lettieris work involving the use of a hypnotic during CPAP titration. A retrospective assessment of 400 consecutive patients prescribed CPAP for OSA showed that of multiple parameters assessed, only age and use of a hypnotic (typically zolpidem) during the CPAP titration were associated with better short-term CPAP compliance.14 This ...

Positive airway pressure therapy. In continuous positive airway pressure (CPAP) and bilevel positive airway pressure (BPAP), small machines gently blow air through a tube and mask attached to your childs nose, or nose and mouth. The machine sends air pressure into the back of your childs throat to keep your childs airway open. Doctors often treat pediatric obstructive sleep apnea with positive airway pressure therapy when medications or removal of adenoids and tonsils is not effective.. Proper fitting of the mask and refitting as the child grows can help the child tolerate the mask over the face. ...

Pediatric obstructive sleep apnea is a medical condition that affects children. It is a sleep-related disorder in which the childs breathing is blocked while sleeping. It is different from adult obstructive sleep, which is primarily caused by obesity. Pediatric obstructive sleep apnea is usually caused by overgrown tonsils and/or adenoids. Symptoms of Pediatric Obstructive SleepRead More. ...

Changes in psychopathological symptoms in sleep apnea patients after treatment with nasal continuous positive airway pressure https://www.upress.umn.edu/test-division/bibliography/1990-1999/1992/ramos_platon_changes_1992 https://www.upress.umn.edu/logo.png ...

TY - JOUR. T1 - Safety and efficacy of postoperative continuous positive airway pressure to prevent pulmonary complications after Roux-en-Y gastric bypass. AU - Huerta, Sergio. AU - DeShields, Scott. AU - Shpiner, Robert. AU - Li, Zhaoping. AU - Liu, Carson. AU - Sawicki, Mark. AU - Arteaga, James. AU - Livingston, Edward H.. PY - 2002. Y1 - 2002. N2 - Continuous positive airway pressure (CPAP) is used to prevent apneic arrest and/or hypoxia in patients suffering from obstructive sleep apnea. This modality has not been universally accepted for patients following upper gastrointestinal surgery because of concerns that pressurized air will inflate the stomach and proximal intestine, resulting in anastomotic disruption. This study was performed to assess the safety and efficacy of postoperative CPAP for patients undergoing a gastrojejunostomy as part of a Roux-en-Y gastric bypass (RYGB) procedure. A total of 1067 patients (837 women [78%] and 230 men [22%]) were prospectively evaluated for the risk ...

In this study we found that treatment of OSA with CPAP did not result in a reduction in weight, and actually was associated with weight gain. This observation was independent of age, gender, race, OSA severity, and sleepiness. Furthermore, those with the greatest adherence to CPAP appeared to have gained the most weight.. The primary finding in this study is that CPAP treatment of OSA does not result in weight loss over a 6-month time frame. Our findings are therefore consistent with those of Redenius et al., who failed to observe in a retrospective study any reduction in weight in 183 CPAP treated patients followed in a sleep center over 10 to 14 months.12 Similarly, several smaller studies also have failed to find a change in weight with CPAP treatment. In a randomized controlled trial of sibutramine in comparison to CPAP for weight loss, CPAP treatment for one year in 18 patients was not associated with a change in weight.11 Similarly, addition of CPAP did not result in greater weight loss ...

Obstructive sleep apnea - Animation Does your significant other complain that your snoring wakes them up during the night or keeps them from getting to sleep in the first place? Do they poke you, waking you up because sometimes theyre afraid you stopped breathing? If so, you may have a condition called obstructive sleep apnea. When you have sleep apnea, the flow of air to your lungs pauses or decreases while you sleep. This happens because your airway has become narrow or blocked. While you sleep, all of the muscles in your body become more relaxed, including the muscles that help keep your airway open, allowing air to flow freely to your lungs. Normally, your upper throat still remains open enough during sleep to let air easily pass by. Some people, however, have a narrowing throat area. When the muscles in their upper throat relax during sleep, their breathing can stop, often for more than 10 seconds. When breathing stops, its called apnea. Often youre not aware that you stopped breathing ...

PMID: 16479762 Purpose: The aim of this study was to evaluate the effect of individually prescribed oral appliances for the treatment of obstructive sleep apnea syndrome (OSAS) on blood pressure, as well as factors influencing the efficacy. Materials and Methods: One hundred sixty-one patients (121 men and 40 women, mean age: 54.3 13.7 years) diagnosed with mild to moderate OSAS (mean apnea-hypopnea index: 17.9 14.1) were studied before and after insertion of a mandibular advancement device, with a mean interval of 60 days. Systolic, diastolic, and mean blood pressure was taken using an automatic blood pressure monitor (132.0 16.1 mmHg, 82.1 10.6 mmHg, 107.1 12.9 mmHg, respectively, at baseline). Results: The patients were subdivided into 3 groups: responder, partial responder, and nonresponder, according to the difference of mean arterial pressure fall after the treatment. The systolic, diastolic, and mean blood pressure decreased significantly (P < .001) (127.5 15.0 mmHg, 79.2 10.0 mmHg, 103.4 ...

OBJECTIVES/HYPOTHESIS: Obstructive sleep apnea syndrome (OSAS) is a chronic condition, characterized by recurrent episodes of upper airway collapse during sleep, which affects up to 5% of adults in the Western population. The muscle tone of the human body ordinarily relaxes during sleep, thus causing airway obstruction and leading to sleep apnea. We report a case of a 68-years old male in which dystonic closure of the larynx during sleep caused OSAS. The sleep endoscopy was crucial in establishing the diagnosis of laryngeal dystonia.

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The BiPAP is bi-level continuous positive airway pressure device that mainly used for home care and clinical treatment of obstructive sleep apnea-hypopnea syndrome (OSAHS) or respiratory insufficiency. CPAP is short for Continuos Positive Airway...

TY - CHAP. T1 - Obstructive Sleep Apnea. AU - Yee, Brendon J.. AU - Grunstein, Ronald R.. PY - 2010/5/11. Y1 - 2010/5/11. KW - Consequences of sleep-disordered breathing. KW - Diagnosis of sleep-disordered breathing. KW - Epidemiology in the general community. KW - Epidemiology in the obese population. KW - Epidemiology: other risk factors for OSA. KW - Familial, genetic and maxillofacial factors. KW - Management of OSA with daytime respiratory failure (including OHS). KW - Obesity hypoventilation syndrome. KW - Pathogenesis of OSA: the role of obesity. KW - Symptoms and signs of sleep-disordered breathing. KW - Uvulopalatopharyngoplasty (UPPP) and other upper airway surgery. UR - http://www.scopus.com/inward/record.url?scp=84886188009&partnerID=8YFLogxK. U2 - 10.1002/9781444307627.ch19. DO - 10.1002/9781444307627.ch19. M3 - Chapter. SN - 9781405182263. SP - 246. EP - 264. BT - Clinical Obesity in Adults and Children. A2 - Kopelman, Peter. A2 - Caterson, Ian. A2 - Dietz, William. PB - ...

Continuous positive airway pressure (CPAP) therapy uses a machine to help a person who has obstructive sleep apnea (OSA) breathe more easily during sleep. A CPAP machine increases air pressure in the throat so your airway does not collapse when you breathe in. You use CPAP at home every night while you sleep.. ...