SCF ubiquitin ligases regulate the ubiquitin-dependent proteolysis of a myriad of substrate proteins, including p27, Cyclin E, and IkBa. To further gain insight into SCF regulation and function, we purified SCF from mammalian cells and found the Cop9 Signalosome associated with SCF. Interestingly, deletion of the CSN in S. pombe resulted in the hypermodification of Cul1 with Nedd8 in vivo. Furthermore, we found that the CSN can promote the removal of Nedd8 from Cul1 in vitro, suggesting CSN regulates SCF through deneddylation. To investigate the basis of CSN-dependent deneddylation activity, we analyzed the CSN and the 26S proteasome for conserved sequences that could be representative of a catalytic motif. We identified the JAMM motif in Csn5 and Rpn11 of the proteasome. Mutations in JAMM eliminated CSN-dependent deneddylating activity. Moreover, mutations in JAMM reduce the restrictive temperature of several SCF temperature sensitive mutants, suggesting that CSN acts positively on SCF ...
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Origin-binding F-box protein; forms an SCF ubiquitin ligase complex with Skp1p and Cdc53p; plays a role in DNA replication; plays a role in transcription; required for correct assembly of RSC complex, correct RSC-mediated transcription regulation, and correct nucleosome positioning; involved in invasive and pseudohyphal growth; required to target Cdc6p for ubiquitin-mediated destruction during G1 phase ...
Dual phosphorylation of S32 and S36 in the TrCP1-binding motif of NF-kappa-B inhibitor alpha (NFKBIA) targets the protein to the SCF ubiquitin ligase complex, which marks it for degradation ...
F-box proteins and DCAF proteins will be the substrate binding subunits of SCF (Skp1-Cul1-F-box protein) and CRL4 (Cul4-RING protein Ligase) ubiquitin ligase complexes respectively. rapid and temporally-controlled proteolysis of key cellular regulators by the ubiquitin-proteasome system (UPS). E3 ubiquitin ligases confer substrate specificity to the UPS. Among the eukaryotic E3s Cullin-RING Ligases (CRLs) constitute the largest family of multi-subunit ubiquitin ligases (Petroski and Deshaies 2005 The archetypes of the CRL family are the CRL1/SCF (Skp1-Cul1-F-box protein) E3s which utilize different F-box proteins (69 in humans) as receptors that bind substrates. Significantly multiple F-box proteins are mutated or display altered expression in a variety of diseases including cancer (Frescas and Pagano 2008 Lipkowitz and Weissman 2011 Skaar et al. 2009 FBXO11 is conserved from nematodes to mammals and both human FBXO11 and its worm ortholog (DRE-1) form functional SCF ubiquitin ligases ...
Skeletal muscle atrophy is a pathological condition characterized by the loss of strength and muscle mass, an increase in myosin heavy chain (MHC) degradation and increase in the expression of two muscle-specific ubiquitin ligases: atrogin-1 and MuRF-1. Angiotensin II (AngII) induces muscle atrophy. Angiotensin-(1-7) [Ang-(1-7)], through its receptor Mas, produces the opposite effects than AngII. We assessed the effects of Ang-(1-7) on the skeletal muscle atrophy induced by AngII. Our results show that Ang-(1-7), through Mas, prevents the effects induced by AngII in muscle gastrocnemius: the decrease in the fibre diameter, muscle strength and MHC levels and the increase in atrogin-1 and MuRF-1. Ang-(1-7) also induces AKT phosphorylation. In addition, our analysis in vitro using C2C12 myotubes shows that Ang-(1-7), through a mechanism dependent on Mas, prevents the decrease in the levels of MHC and the increase in the expression of the atrogin-1 and MuRF-1, both induced by AngII. Ang-(1-7) ...
The F-box domain is a protein structural motif of about 50 amino acids that mediates protein-protein interactions. The F-box protein is one of the four components of the SCF (SKp1, Cullin, F-box protein) complex, which mediates ubiquitination of proteins targeted for degradation by the proteasome, playing an essential role in many cellular processes. Several discoveries have been made on the use of the ubiquitin-proteasome system by viruses of several families to complete their infection cycle. On the other hand, F-box proteins can be used in the defense response by the host. This review describes the role of F-box proteins and the use of the ubiquitin-proteasome system in virus-host interactions.
The F-box domain is a protein structural motif of about 50 amino acids that mediates protein-protein interactions. The F-box protein is one of the four components of the SCF (SKp1, Cullin, F-box protein) complex, which mediates ubiquitination of proteins targeted for degradation by the proteasome, playing an essential role in many cellular processes. Several discoveries have been made on the use of the ubiquitin-proteasome system by viruses of several families to complete their infection cycle. On the other hand, F-box proteins can be used in the defense response by the host. This review describes the role of F-box proteins and the use of the ubiquitin-proteasome system in virus-host interactions.
Chickens are bred all over the world and have significant economic value as one of the major agricultural animals. The growth rate of commercial broiler chickens is several times higher than its Red Jungle fowl (RJF) ancestor. To further improve the meat production of commercial chickens, it is quite important to decipher the genetic mechanism of chicken growth traits. In this study, we found that broiler chickens exhibited lower levels of E3 ubiquitin ligase muscle atrophy F-box (MAFbx or Atrogin-1) relative to its RJF ancestor. As a ubiquitin ligase, Atrogin-1 plays a crucial role in muscle development in which its up-regulation often indicates the activation of muscle atrophic pathways. Here, we showed that the Atrogin-1 expression variance partly affects chicken muscle growth rates among different breeds. Furthermore, we demonstrated that the reduced expression of Atrogin-1 in broiler chickens was ascribed to a single nucleotide polymorphism (SNP), which inhibited the binding of ...
Van Rechem and colleagues also showed with a drug screen (87 preclinical and clinical compounds) against 86 genotyped lung cancer cell lines that cells homozygous for a coding single-nucleotide polymorphism (SNP) in KDM4A (SNP-A482) were hypersensitive to mTOR inhibitors. Biochemical analysis of SNP-A482 revealed decreased stability in KDM4A, which was attributed to polyubiquitination by the Skp, Cullin, F-box (SCF) ubiquitin ligase complex that resulted in increased protein turnover. These data suggest that SNP-A482 may be a biomarker for mTOR sensitivity, and, indeed, Van Rechem and colleagues showed that SNP-A482 is associated with poor prognosis in patients with non-small cell lung cancer. Collectively, these data redefine the role of KDM4A and highlight a new function for this demethylase outside the nucleus as a regulator of protein translation. By demonstrating that KDM4A inhibition can be achieved by a small molecule, and with the realization that a coding SNP potentiates the therapeutic ...
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it is upregulated in nasopharyngeal carcinoma. [provided by RefSeq, Jul 2008 ...
The kinase eEF2K [eukaryotic elongation factor 2 (eEF2) kinase] controls the rate of peptide chain elongation by phosphorylating eEF2, the protein that mediates the movement of the ribosome along the mRNA by promoting translocation of the transfer RNA from the A to the P site in the ribosome. eEF2K-mediated phosphorylation of eEF2 on threonine 56 (Thr56) decreases its affinity for the ribosome, thereby inhibiting elongation. Here, we show that in response to genotoxic stress, eEF2K was activated by AMPK (adenosine monophosphate-activated protein kinase)-mediated phosphorylation on serine 398. Activated eEF2K phosphorylated eEF2 and induced a temporary ribosomal slowdown at the stage of elongation. Subsequently, during DNA damage checkpoint silencing, a process required to allow cell cycle reentry, eEF2K was degraded by the ubiquitin-proteasome system through the ubiquitin ligase SCFβTrCP (Skp1-Cul1-F-box protein, β-transducin repeat-containing protein) to enable rapid resumption of translation ...
RPM-1 functions as part of an E3 ubiquitin ligase/SCF complex that includes FSN-1. This complex ubiquitinates and destroys DLK-1 to negatively regulate a MAP kinase pathway (Nakata et al. 2005). RPM-1 is part of a conserved protein family called PHR proteins, and PHR proteins in flies and mice also function as part of SCF complexes to regulate synapse formation and neuronal development (Burgess et al. 2004; Collins et al. 2006; Lewcock et al. 2007; Wu et al. 2007; Saiga et al. 2009; Tada et al. 2009). Thus, negative regulation of the DLK-1/Dlk pathway represents an essential, evolutionarily conserved function of the PHR proteins. While PHR proteins represent one mechanism for negatively regulating the DLK-1 pathway, it remains uncertain if other, complementary mechanisms also restrain the activity of this pathway. Here we provide evidence of a conserved PP2Cα/β phosphatase, PPM-1, that also negatively regulates the DLK-1 pathway.. Our analysis shows that loss of function in ppm-1 results in ...
Cullin proteins comprise a distinct family of mediators that participate in the selective targeting of proteins for ubiquitin (Ub)-mediated proteolysis. CUL-1, which is the mammalian homolog of yeast Cdc53, is an integral component of the E3 ubiquitin ligase complex designated SCF. The SCF (Skp1/CUL-1/F-box protein complex) consists of Skp1 associating with both CUL-1 and an F-box protein, such as Skp2, which determines the substrate specificity of the complex. CUL-1-mediated ubiquitination results in the degradation of cell cycle proteins cyclin D, p21 and cyclin E. Another cullin, CUL-3, facilitates the degradation of cyclin E independent of SCF activity, while CUL-2 associates with the tumor suppressing protein VHL and elongin B to form VBC complexes, which structurally resemble the SCF ligase. Proteolysis also occurs by way of CUL-4 associating with Nedd-8, a ubiquitin-like protein, where it too functions as an active component of a multifunctional E3 complex. CUL-5, also designated ...
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the cyclin family. Cyclins are important regulators of cell cycle transitions through their ability to bind and activate cyclin-dependent protein kinases. This member also belongs to the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it was one of the first proteins in which the F-box motif was identified. [provided by RefSeq, Jul 2008 ...
Description: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class and, in addition to an F-box, contains multiple WD40 repeats. This gene contains at least 14 exons, and its alternative splicing generates 3 transcript variants diverging at the presence/absence of two alternate exons ...
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats and is localized in the nucleus. [provided by RefSeq, Jul 2008 ...
FBXO4 Full-Length MS Protein Standard (NP_036308), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Gene Information This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box) which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains Fbls containing leucine-rich repeats and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is similar to xenopus early mitotic inhibitor-1 (Emi1) which is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq Dec 2008]. ...
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008] ...
We provide human molecular genetic and in vitro and in vivo functional evidence to implicate TRIM63, encoding MuRF1, an E3 ubiquitin ligase, as a likely causal gene for human HCM. The p.A48V, p.I130M and p.Q247* variants were exclusive to the HCM study population (whites) and were not detected in over 500 control white individuals. The small size of the families was not permissive to genotype-phenotype cosegregation analysis, which is a limitation of the study. The nonsense (p.Q247*) and the p.A48V variants recurred in 2 families. The nonsense variant led to premature truncation and loss of approximately one-third of the protein. The p.A48V and p.I130M variants affected highly conserved amino acids and were predicted-in silico-to be probably damaging to protein structure and function. Functionally, the variants had loss-of-function effects on E3 ubiquitin ligase activity, as detected in specialized ubiquitin-tagged HeLa cells, virally transduced adult cardiac myocytes, and transgenic hearts. ...
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Cardiac hypertrophy is viewed as a compensatory response to increased load common to diverse clinical settings such as hypertension, valvular disease, and inherited cardiomyopathies (Sadoshima and Izumo, 1997; MacLellan and Schneider, 2000). Myocytes respond to pressure overload with the addition of sarcomeres, resulting in an increase in ventricular wall thickness, which itself is an independent risk factor for cardiovascular mortality (Mathew et al., 2001; Verdecchia et al., 2001). Hence, blunting hypertrophic growth might be beneficial to cardiac function, and previous studies of genetically engineered mice disrupting certain hypertrophic pathways confirm this prediction (Esposito et al., 2002; Sano and Schneider, 2002). However, we still do not know which pathways hold greatest potential for therapeutic benefit. Although the signaling pathways that activate hypertrophy have been described in detail (McKinsey and Olson, 1999; Molkentin and Dorn, 2001), still very little is known of mechanisms ...
NF-kappaB transcription factor is activated upon ubiquitination and subsequent proteolysis of its inhibitor IkappaB. The phosphorylation-dependent ubiquitination is mediated by SCF E3 ubiquitin ligase. In this study, we identified a novel murine F-box/WD40 repeat-containing protein, mHOS (a homologue of HOS/betaTrCP2). mHOS efficiently binds Skp1 protein (a core component of SCF ubiquitin ligase), and phosphorylated IkappaB(alpha). We found that mHOS associates with SCF-ROC1 E3 ubiquitin ligase activity. We have also observed that mHOS is overexpressed in chemically-induced mouse skin tumors, and its overexpression (but not accelerated IkappaB phosphorylation) coincides with the accelerated degradation of IkappaB in vivo. The role of mHOS in the constitutive activation of NF-kappaB in skin carcinogenesis is discussed. ...
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Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the polyubiquitination and proteasomal degradation of CAMK1 leading to disruption of cyclin D1/CDK4 complex assembly which results in G1 cell cycle arrest in lung epithelia.
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Complete information for FBXO28 gene (Protein Coding), F-Box Protein 28, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
Complete information for FBXO48 gene (Protein Coding), F-Box Protein 48, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
FBXL10b, 0.4 ml. This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box.
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Plasmid pDONR223_FBXO16_p.T50K from Dr. Jesse Boehms lab contains the insert FBXO16 and is published in Cancer Discov. 2016 Jul;6(7):714-26. doi: 10.1158/2159-8290.CD-16-0160. Epub 2016 May 4. This plasmid is available through Addgene.
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F-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 aminoacid motif, the F box (so named because cyclin F was one of the first proteins in which this motif was identified) [1]. Some F-box proteins have been shown to be critical for the controlled degradation of cellular regulatory proteins [2] [3]. In fact, F-box proteins are one of the four subunits of ubiquitin protein ligases called SCFs. The other three subunits are the Skp1 protein; one of the cullin proteins (Cul1 in metazoans and Cdc53 or Cul A in the yeast Saccharomyces cerevisiae); and the recently identified Roc1 protein (also called Rbx1 or Hrt1). SCF ligases bring ubiquitin conjugating enzymes (either Ubc3 or Ubc4) to substrates that are specifically recruited by the different F-box proteins. The need for high substrate specificity and the large number of known F-box proteins in yeast and worms [2] [4] suggest the existence of a large family of mammalian F-box proteins. Using Skp1 as a ...
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the genes potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different ...
We report the map-based cloning of the SLY1 gene of Arabidopsis. SLY1 is a positive regulator of GA response. Recessive mutations in SLY1 affect the full range of GA phenotypes, including feedback regulation of the GA3ox1 biosynthetic gene (Figure 1). Thus, the fact that SLY1 encodes a putative F-box protein suggests that the GA signal is transmitted via an SCFSLY1 E3 ubiquitin ligase.. Ubiquitylation controls target protein activity at multiple levels, including proteolysis and the potentiation of transcriptional activation domains (Conaway et al., 2002). Major members of the SCF complex include homologs of SKP1, cullin, and the RING-finger domain protein Rbx1 (Zheng et al., 2002). The F-box subunit directs the interaction of the complex with a specific target for ubiquitylation. The conserved F-box domain allows the protein to interact with the SKP1 subunit of the SCF. SKP1 tethers the F-box protein to the N terminus of cullin. The RING-finger protein Rbx1 binds the C terminus of cullin and ...
Several experimental points support the proposal that p45SKP2 is a component of a potential human SCF‐type E3 ligase. First, two yeast F‐box proteins, CDC4 and GRR1, were shown to complex independently with CDC53 and SKP1 and function as specific SIC1 and CLN receptors, respectively (Skowyra et al., 1997). In fact, purified CDC4-CDC53-SKP1 complexes mixed together with CDC34 and an E1 were found to be necessary and sufficient for the multi‐ubiquitination of SIC1 in vitro. We found that p45SKP2 also interacts with a member of the cullin family, CUL‐1, in vivo. Association was established by direct co‐immunoprecipitation in vitro and in vivo (Figures 2 and 3). In addition, p45SKP2 was capable of relocalizing CUL‐1 to the nucleus when both proteins were co‐synthesized (Figure 2F). Although the exact function(s) of cullins remain to be determined, the yeast homolog of CUL‐1, CDC53, has been clearly implicated in the degradation of critical cell cycle regulatory proteins. Genetic ...
From NCBI Gene:. This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It can function as an arginine methyltransferase that symmetrically dimethylates arginine residues, and it acts as an adaptor protein to mediate the neddylation of p53, which leads to the suppression of p53 function. This gene is known to be down-regulated in melanocytes from patients with vitiligo, a skin disorder that results in depigmentation. Polymorphisms in this gene are associated with chronic ...
the evolutionary conserved f-box motifs can be found in various organisms ranging from fungi, insects, fish, and mammals to plants. f-box proteins are subunits of SCF-type E3 ubiquitin ligases and selectively recruit target proteins via their protein-protein interaction domain for ubiquitination and subsequent proteasomal degradation. the arabidopsis genome encodes appr. 700 f-box proteins which makes this gene superfamily one of the largest in eukaryotes. however, a biological function has been assigned to less than 30 genes/proteins of the 700 members. We are generally interested in the evolution and selection patterns acting on f-box proteins (see Schumann et al., 2011 in press) and study a small sub-family to understand the molecular functions of each member. ...
Members of the F-box protein family, such as FBXL18, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data ...
In response to DNA damage, eukaryotic cells initiate a complex signalling pathway, termed the DNA damage response (DDR), which coordinates cell cycle arrest with DNA repair. Studies have shown that oncogene-induced senescence, which provides a barrier to tumour development, involves activation of the DDR. Using a genome-wide RNA interference (RNAi) screen, we have identified 17 factors required for oncogenic BRAF to induce senescence in primary fibroblasts and melanocytes. One of these factors is an F-box protein, FBXO31, a candidate tumour suppressor encoded in 16q24.3, a region in which there is loss of heterozygosity in breast, ovarian, hepatocellular and prostate cancers. Here we study the cellular role of FBXO31, identify its target substrate and determine the basis for its growth inhibitory activity. We show that ectopic expression of FBXO31 acts through a proteasome-directed pathway to mediate the degradation of cyclin D1, an important regulator of progression from G1 to S phase, resulting in
www.MOLUNA.de Oxidative Stress and Cardiorespiratory Function [4498550] - Cardiorespiratory function is prominently affected by oxidative stress. Cigarette smoking is the archetype of oxidative and nitrative stress and free radical formation. New adverse effects of smoking keep on propping up in research. The chapters provide the comprehensive view of new developments in this area regarding cardiovascular and lung function
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Role in neural transmission (By similarity).
The phytohormone gibberellin (GA) controls growth and development in plants. Previously, we identified a rice F-box protein, gibberellin-insensitive dwarf2 (GID2), which is essential for GA-mediated DELLA protein degradation. In this study, we analyzed the biological and molecular biological propert …
TY - JOUR. T1 - Atrogin-1 Pathway Activation in Cushing Syndrome Cardiomyopathy. AU - Frustaci, Andrea. AU - Letizia, Claudio. AU - Verardo, Romina. AU - Grande, Claudia. AU - Calvieri, Camilla. AU - Russo, Matteo Antonio. AU - Chimenti, Cristina. PY - 2016/1/5. Y1 - 2016/1/5. UR - http://www.scopus.com/inward/record.url?scp=84952900679&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=84952900679&partnerID=8YFLogxK. U2 - 10.1016/j.jacc.2015.10.040. DO - 10.1016/j.jacc.2015.10.040. M3 - Article. C2 - 26764074. AN - SCOPUS:84952900679. VL - 67. SP - 116. EP - 117. JO - Journal of the American College of Cardiology. JF - Journal of the American College of Cardiology. SN - 0735-1097. IS - 1. ER - ...
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Buy our Recombinant Human F Box G - Domain 3 protein. Ab161964 is a protein fragment produced in Wheat germ and has been validated in WB, ELISA. Abcam provides…