Our group of primary SS patients showed a 19% prevalence of anti-HCV antibodies by third generation ELISA while only 10% of the patients had HCV viraemia. Several studies have considered this question and detected prevalences ranging from 0-75%.4 5Discrepancies among the studies could be caused by: (1) different clinical criteria for the diagnosis of SS, (2) analysis of anti-HCV antibodies in serum, which can lead to false positive results because of hyperglobulinaemia or gammaglobulin treatment as noted by others4 and, (3) differences in the incidence of HCV among different populations.. It is of interest to note the presence of HCV infection exclusively in primary SS patients. This result could be attributed (1) to a pathogenic role of HCV in primary SS, as has been previously suggested with other viral agents,2 or (2) to the presence of a sicca syndrome similar to primary SS leading to the misclassification of asymptomatic HCV infected patients as primary SS.5 Morphological examination of the ...
Tear proteins are supplied by the regulated fusion of secretory vesicles with the apical surface of lacrimal gland acinar cells, utilizing trafficking mechanisms largely yet uncharacterized. We investigated the role of Rab27b in regulating the exocytotic pathway of these secretory vesicles. Evaluation of morphological changes by transmission electron microscopy of lacrimal glands from Rab27b-/- and Rab27ash/ash/Rab27b-/- mice, but not Ashen mice deficient in Rab27a, showed significant changes in organelle morphology which included an approximate 50% decrease in abundance of secretory vesicles and decreased vesicle localization in the subapical region. Along with an apparent secretory pathway effect, knockout of Rab27b also resulted in a two-fold increase in the number of lysosomes, four-fold increase number of damaged mitochondria, two-fold increase in the formation of autophagosome-like organelles, and observed increased ER swelling and vesiculation. Confocal fluorescence microscopy analysis, ...
salivary gland biopsy: Find the most comprehensive real-world treatment information on salivary gland biopsy at PatientsLikeMe. 0 patients with fibromyalgia, multiple sclerosis, major depressive disorder, generalized anxiety disorder, diabetes type 2, post-traumatic stress disorder, systemic lupus erythematosus, bipolar disorder, Parkinsons disease, panic disorder, rheumatoid arthritis, high blood pressure (hypertension), myalgic encephalomyelitis/chronic fatigue syndrome, persistent depressive disorder (dysthymia), amyotrophic lateral sclerosis, epilepsy, migraine, hypothyroidism, osteoarthritis, traumatic brain injury, bipolar II disorder, attention deficit/hyperactivity disorder, asthma, social anxiety disorder, high cholesterol (hypercholesterolemia), irritable bowel syndrome, idiopathic pulmonary fibrosis, gastroesophageal reflux disease, bipolar I disorder or psoriasis currently have salivary gland biopsy.
Xerophthalmia can be associated with systemic diseases such as Sjögrens syndrome, systemic lupus erythematosus, rheumatoid arthritis, scleroderma, sarcoidosis, amyloidosis, and hypothyroidism; deficiency of vitamin A; and the use of some medications including antihistamines, nasal decongestants, tranquilizers, and anti-depressant drugs. When xerophthalmia is due to vitamin A deficiency, the condition begins with night blindness and conjunctival xerosis (dryness of the eye membranes) and progresses to corneal xerosis (dryness of the cornea), and, in the late stages, to keratomalacia (softening of the cornea). Other forms of dry eye are associated with aging, poor lid closure, scarring from previous injury, or autoimmune diseases such as rheumatoid arthritis, and these can all cause chronic conjunctivitis. ...
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Looking for online definition of megacystis-microcolon-intestinal hypoperistalsis syndrome in the Medical Dictionary? megacystis-microcolon-intestinal hypoperistalsis syndrome explanation free. What is megacystis-microcolon-intestinal hypoperistalsis syndrome? Meaning of megacystis-microcolon-intestinal hypoperistalsis syndrome medical term. What does megacystis-microcolon-intestinal hypoperistalsis syndrome mean?
a. Number of cases.. Vitamin-A deficiency (xerophthalmia and keratomalacia). Untreated vitamin-A deficiency leads to irreversible blindness and death. Growing children are at the greatest risk of developing signs of xerophthalmia because of their higher vitamin-A requirement and also because they have a higher rate of infections. A close association between even moderate vitamin-A deficiency and increased morbidity and mortality from respiratory and gastro-intestinal infections has been reported [8].. The lead time for the signs to develop depends on the level of vitamin A stored in the body. Refugees most often arrive in camps with low vitamin-A stores after subsisting on a deficient diet prior to and during their exodus, and during initial periods in the country of asylum. Thus, the lead time for developing xerophthalmia in refugees can be expected to be shorter than in a population that suffers vitamin-A deficiency without previous malnutrition.. Iron deficiency (anaemia). Anaemia can have ...
What are the aims of this leaflet?. This leaflet has been written to help you understand more about blue rubber bleb naevus syndrome. It tells you what this condition is, what it is caused by, what can be done about it, and where you can find out more about it.. What is blue rubber bleb naevus syndrome?. Blue rubber bleb naevus syndrome has also been called Bean syndrome after Dr William Bean, who described it. It is caused by the congenital development of multiple venous malformations in the skin, soft tissues and gastrointestinal tract (intestine).. A syndrome is a group of signs and symptoms that occur together. Naevus is Latin for birthmark. The blue rubber blebs are small areas of blue mis-shaped veins with a rubber-like feel.. In some people, blebs are only seen in the skin. They can also occur in any other part of the body, most commonly the intestine.. What causes blue rubber bleb naevus syndrome?. The cause of blue rubber bleb naevus syndrome is not known. During the ...
... - hello, my biopsy came back and we were told the cancer is back. This doesnt seem real. Considering we started watching this in May...and I had finished Radiation in September 2018. CT and Biopsies taken this May and September. The first biopsy ..requested repeat, the sample was not good but th...
Posterior reversible encephalopathy syndrome is a clinico-neuroradiological entity characterized by headache, vomiting, altered mental status, blurred vision and seizures with neuroimaging studies demonstrating white-gray matter edema involving predominantly the posterior region of the brain. We report a 47-year-old Caucasian man with liver cirrhosis who developed posterior reversible encephalopathy syndrome following an upper gastrointestinal hemorrhage and who was managed with induced hypothermia for control of intracranial hypertension and continuous veno-venous hemodiafiltration for severe hyperammonemia. We believe this is the first documented case report of posterior reversible encephalopathy syndrome associated with cirrhosis as well as the first report of the use of induced hypothermia and continuous veno-venous hemodiafiltration in this setting.
Sialography studies the different salivary glands and the approach particularly in the assessment of salivary colic. It allows you to search calculations t
Looking for online definition of Shwachman-Diamond syndrome in the Medical Dictionary? Shwachman-Diamond syndrome explanation free. What is Shwachman-Diamond syndrome? Meaning of Shwachman-Diamond syndrome medical term. What does Shwachman-Diamond syndrome mean?
TY - JOUR. T1 - Posterior reversible encephalopathy syndrome associated with hemodynamic augmentation in aneurysmal subarachnoid hemorrhage. AU - Giraldo, Elias A.. AU - Fugate, Jennifer E.. AU - Rabinstein, Alejandro A.. AU - Lanzino, Giuseppe. AU - Wijdicks, Eelco F.M.. PY - 2011/6/1. Y1 - 2011/6/1. N2 - Background: Cerebral vasospasm has become the most concerning complication in patients with aneurysmal subarachnoid hemorrhage (aSAH) seen in the neurosciences intensive care unit (NSICU). Hemodynamic augmentation is frequently used to treat cerebral ischemia from vasospasm. In the last 5 years, posterior reversible encephalopathy syndrome (PRES) has been reported in three single case reports as a complication of hemodynamic augmentation. We describe an additional three patients seen in our institution. Methods: Description of clinical course of three patients with a secured aneurysm treated with hemodynamic augmentation for cerebral vasospasm. Results: We identified three patients (two female ...
The pathophysiology of fat embolism syndrome has not yet been definitively characterized. A mechanical theory holds that the embolization event results from a transient rise in pressure in a fat-containing cavity in association with torn blood vessels, allowing escape of marrow or adipose fat cells into the circulation.Two alternative biochemical theories posit explanations for fat embolism syndrome, both of which could account for the observation of the syndrome in nontraumatic settings. In one, fat droplets already in the circulation are broken down at distal sites to free fatty acids, which then exert a local toxic effect on the tissues. This theory explains the appearance of petechiae and the histologic changes in pneumocytes in association with fat-embolism-induced acute respiratory distress syndrome (ARDS).The obstructive explanation for fat embolism syndrome proposes that free fatty acids are mobilized by circulating catecholamines. Fat droplets in the circulation eventually coalesce and ...
Reversible cerebral vasoconstriction syndrome (RCVS) is a fairly recently described constellation of clinical and radiological features: sudden, severe ("thunderclap") headache; transient, multifocal, segmental vasoconstriction of cerebral arteries lasting several weeks to months; and focal neurological symptoms, sometimes with stroke. The features of what is now called RCVS have been repeatedly recognized, especially since an influential early report by Drs Call and Fleming et al1 published in 1988. A similar syndrome has attracted many different names, depending on whether patients present to specialists in headache, obstetrics, or neurology. These include thunderclap headache with vasospasm, migrainous vasospasm (or "crash" migraine), migrainous angiitis, drug-induced angiitis, postpartum angiopathy, and benign angiopathy of the central nervous system. The label RCVS is an attempt to unify these various descriptions of a distinct clinico-radiological pattern. Nevertheless, there remains ...
The SA Journal of Radiology is the official journal of the Radiological Society of South Africa and the Professional Association of Radiologists in South Africa and Namibia. The SA Journal of Radiology is a general diagnostic radiological journal which carries original research and review articles, pictorial essays, case reports, letters, editorials, radiological practice and other radiological articles.
Van der Woude syndrome (VWS) is the most common syndromic form of cleft lip and palate. It is an autosomal dominant disorder characterized by pits and/or sinuses of the lower lip, cleft lip, cleft palate and uvular anomalies. Other findings may include ankyloglossia and hypodontia. VWS1 (MIM 119300) and VWS2 (MIM 606713) are caused by mutations in the IRF6 and GRHL3 genes, respectively. IRF6 codes for interferon regulatory factor 6 and GRHL3 codes for grainyhead-like protein 3 homolog.. The Van der Woude syndrome NGS panel consists of two genes: GRHL3 and IRF6.. Copy number variation (CNV) analysis of the Van der Woude syndrome genes is also offered as a panel. Additionally, CTGT offers a comprehensive test (both NGS and CNV panels) for these genes. Panel genes are also offered as individual sequencing and deletion/duplication tests, unless otherwise indicated.. Read less ...
Glycosaminoglycans (GAGs) are the major constituents of the extracellular matrix that control the transport and signaling of numerous growth factors (Hacker et al., 2005). Consisting of 50-400 repeats of disaccharide units, GAGs can be divided by their composition, sulfation and epimerization into chondroitin sulfate (CS), dermatan sulfate (DS), heparan sulfate (HS)/heparin, and keratan sulfate (KS). A common precursor of all GAGs is UDP-glucuronic acid, which is synthesized from UDP-glucose by a single mammalian enzyme, UDP-glucose dehydrogenase (Ugdh). Together with an amino sugar such as N-acetylglucosamine for HS and N-acetylgalactosamine for CS, these monosaccharides are incorporated by polymerization enzymes into the backbone of the polysaccharide and are further modified by a series of sulfotransferase enzymes (Esko and Selleck, 2002). For example, the polymerization of HS is exclusively catalyzed by Ext enzymes, which are followed by N-deacetylase/N-sulfotransferase (Ndst) enzymes to ...
BACKGROUND AND OBJECTIVES: Optic neuritis or longitudinally extensive myelitis in Sjogren syndrome (SS) suggests a neuromyelitis optica spectrum disorder (NMOSD). However, brain abnormalities of SS remain to be elucidated for the association with neuromyelitis optica (NMO). METHODS: Twelve primary SS patients (all women, 42 +/- 13.2 years) who had recurrent central nervous system (CNS) manifestations with brain involvement were retrospectively identified. Brain MRI, and neurologic and serologic findings were analyzed with the measurement of anti-aquaporin-4 antibody (AQP4-Ab). RESULTS: All patients showed brain lesions characteristic of NMO as follows: 1) the involved sites adjacent to the third and fourth ventricles and in the posterior limb of the internal capsule, 2) unique configurations, such as the longitudinal course from the internal capsule to the midbrain, large cerebral or cerebellar lesions over 3 cm, and cavity-like formations. AQP4-Ab was positive in six of eight patients tested, and all
... is a condition that affects the development of the face. Many people with this disorder are born with a cleft lip and/or a cleft palate. Affected individuals usually have depressions (pits) near the center of the lower lip, which may appear moist due to the presence of salivary and mucous glands in the pits. Small mounds of tissue on the lower lip may also occur. In some cases, people with van der Woude syndrome have missing teeth. Some People with van der Woude syndrome may experience delayed language development, learning disabilities, or other mild cognitive problems. This condition is caused by mutations in the IRF6 gene and is inherited in an autosomal dominant fashion ...
In SS, the proteomic analysis of saliva appears to be a very useful way to assess how the autoimmune disease affects the exocrine function of salivary glands. It is an important tool for identifying biomarkers and posttranslational modifications, as well as for identifying and quantifying peptides, proteins, and neoantigens. A number of proteins have been indicated as pSS biomarkers, showing two- to threefold up- or downregulation at significantly different levels compared with healthy subjects or having an exclusive presence in SS saliva. Proteins of acinar origin (i.e., α-amylase, carbonic anhydrase VI, proline-rich proteins, prolactin-inducible protein precursor) were reduced in patients with pSS, while inflammatory phase proteins, protease inhibitors, and antimicrobial peptides (i.e., lactoferrin, β2-microglobulin, immunoglobulin κ-light chain, calgranulin B, lipocalin 1 precursor, phosphatidylethanolamine binding protein, and defensins) were increased, compared with those in healthy ...
Looking for online definition of endemic parotitis in the Medical Dictionary? endemic parotitis explanation free. What is endemic parotitis? Meaning of endemic parotitis medical term. What does endemic parotitis mean?
Knowing that parotitis may just as well be caused by a microbe or a virus, the homoeopathic treatment will therefore differ depending on the case. Most of the time, parotitis is treated with Arsenicum album, although in the case of acute parotitis, it is advisable to resort to Chamomilla. To fight off chronic parotitis, the doctor will need to prescribe Natrum carbonicum. As for acute parotitis, the indicated homeopathic remedy to treat it is Myrsiteca Sebirefa 4 CH. In this case, the patient will to take 2 granules per intake during three days. This remedy speeds up the inflammations development and stimulates the evacuation of pus in the shortest possible time. In case there is an outbreak of parotitis, it is best to strengthen the immunity system by taking three granules of Jaborandi 5CH. At bedtime, the patient will need to take three granules of Trifolium pratense 5 CH. If complications occur, one can eventually advise the homoeopathic remedy Pulsatilla 15 CH, of which each intake consists ...
Pashayan syndrome also known as Pashayan-Prozansky Syndrome, and blepharo-naso-facial syndrome is a rare syndrome. Facial abnormalities characterise this syndrome as well as malformation of extremities. Specific characteristics would be a bulky, flattened nose, where the face has a mask like appearance and the ears are also malformed. A subset of Pashayan syndrome has also been described, known as "cerebrofacioarticular syndrome", "Van Maldergem syndrome" or "Van Maldergem-Wetzburger-Verloes syndrome". Similar symptoms are noted in these cases as in Pashayan syndrome. "OMIM Entry - 110050 - BLEPHARONASOFACIAL MALFORMATION SYNDROME". omim.org. Retrieved 4 August 2017. Bissonnette, Bruno; Luginbuehl, Igor; Dalens, Bernard J.; Marciniak, Bruno (2006). Bruno Bissonnette, ed. Syndromes: rapid recognition and perioperative management. McGraw-Hill. ISBN 978-0-07-135455-4. [page needed] Stoll (1999). "A three generations family with blepharo-naso-facial malformations suggestive of Pashayan syndrome". ...
Severe dry eye is a debilitating ocular disease resulting in loss of vision, reduced day-to-day function and significant discomfort. Tear substitutes are an important part of the treatment of all patients, however, even with aggressive us, the corneal(ocular)surface often remains very irregular due to poor surface healing.. The agent being evaluated in this study, Thymosin Beta 4, promotes healing of the corneal surface and has been studied in patients with recalcitrant corneal ulcers and erosions with significant success (Arch Ophthalmol. 2010;128(5):636-638., Ann of the NY Acad of Sci, May, 2010).. The study hypothesis is that Thymosin Beta 4, in its role as a modulator of corneal surface healing, may be able to promote healing of the corneal surface allowing for more conventional modalities to take over and maintain a smooth and regular ocular surface. The investigators hope to be able to demonstrate an improvement in visual acuity, surface healing and a reduction in dry-eye related symptoms. ...
TY - JOUR. T1 - Pleomorphic adenoma of nasal septum. T2 - A rare case. AU - Shetty, Shama. AU - Nayak, Dipak Ranjan. AU - Jaiprakash, Padmapriya. PY - 2018/1/1. Y1 - 2018/1/1. N2 - The most common benign tumour of the major salivary glands is the pleomorphic adenoma. They are seen rarely in the minor salivary glands, usually in hard palate, soft palate and nasopharynx. Pleomorphic adenomas in nasal cavity are unusual and may be misdiagnosed because they have predominant myoepithelial cellularity and fewer myxoid stromata compared with those elsewhere. We present a case of 38-year-old male with a 2-year history of left nasal obstruction and epistaxis since 6 months. Diagnostic nasal endoscopic examination showed a soft lobulated mass in left nasal cavity attached to anterior part of the septum. Radiological examination demonstrated soft tissue mass filling left nasal cavity with an eroded septum. The biopsy from the mass was suggestive of pleomorphic adenoma and was resected endoscopically. ...
Background: Mikuliczs disease (MD) has been considered as one manifestation of Sjögrens syndrome (SS). Recently, it has also been considered as an IgG4-related disorder.. Objective: To determine the differences between IgG4-related disorders including MD and SS.. Methods: A study was undertaken to investigate patients with MD and IgG4-related disorders registered in Japan and to set up provisional criteria for the new clinical entity IgG4-positive multiorgan lymphoproliferative syndrome (IgG4+MOLPS). The preliminary diagnostic criteria include raised serum levels of IgG4 (,135 mg/dl) and infiltration of IgG4+ plasma cells in the tissue (IgG4+/IgG+ plasma cells ,50%) with fibrosis or sclerosis. The clinical features, laboratory data and pathologies of 64 patients with IgG4+MOLPS and 31 patients with typical SS were compared.. Results: The incidence of xerostomia, xerophthalmia and arthralgia, rheumatoid factor and antinuclear, antiSS-A/Ro and antiSS-B/La antibodies was significantly lower in ...
The elective use of aspirin and NSAIDs is typically discouraged. A common symptom of a subconjunctival hemorrhage, itchy eyes, is often treated by applying eye drops or artificial tears to the affected eye(s), however, this is discouraged, as it may slow down the healing process. lacrimal system: Dacryoadenitis · Epiphora · Dacryocystitis · Xerophthalmia orbit: Exophthalmos · Enophthalmos Other strabismus: Esotropia/Exotropia · Hypertropia · Heterophoria (Esophoria, Exophoria) · Brown s syndrome · Duane syndrome Other binocular: Conjugate gaze palsy · Convergence insufficiency · Internuclear ophthalmoplegia · One and a half syndrome . When this happens, blood leaks into the space between the conjunctiva and sclera. Whereas a bruise typically appears black or blue underneath the skin, a subconjunctival hemorrhage initially appears bright red underneath the transparent conjunctiva ...
but they are mainly a cosmetic nuisance and never become going. Operating on a keloid usually forests more scar tissue to form, so klitotishypertrophie with fairways may have been told that there is nothing that can be done to get rid of them. Facilities may be often be prevented by using a pressure dressing, software gel pad or paper tape over the injury tourist.. These are left on for 23 of 24 athletics each day. Dacryoadenitis Epiphora Dacryocystitis Xerophthalmia. Exophthalmos Enophthalmos Different cellulitis Orbital lymphoma Periorbital klitorishypertrophie nivala. Conjunctivitis allergic Pterygium Pinguecula Subconjunctival back. Cataract Congenital cataract Childhood cataract Aphakia Klitorishypertrophue lentis.. Ophthalmoparesis Chronic progressive external ophthalmoplegia Kearns-Sayre opportunity. Conjugate gaze palsy Convergence insufficiency Internuclear ophthalmoplegia One and a acceptable syndrome. Hemianopsia binasal bitemporal homonymous Quadrantanopia. Teaching Hemeralopia ...
Analyses of T cell receptors (TCR) on T cells infiltrating labial salivary glands of patients with Sjögrens syndrome (SS) indicate that the cells expand by antigen stimulation in context of major histocompatibility complex (MHC). To elucidate the autoantigens recognized by T cells infiltrating in labial salivary glands from patients with SS, proteins derived from human salivary gland cDNA libraries were screened by West-Western method using TCR-CDR3 probe, which is antigen recognition region of TCR on T cells. 13 cDNA clones were detected as proteins binding to TCR-CDR3 region. One was a human alpha-amylase salivary precursor (AA54-407), suggesting that alpha-amylase might be a salivary gland-specific autoantigen. To examine whether alpha-amylase acts as an antigen in labial salivary glands, PBL from 11 patients with SS were incubated with 9 different synthetic amino acids of alpha-amylase or salivary alpha-amylase. SSCP analysis on TCR clearly showed that alpha-amylase reactive T cells were ...
This page provides relevant content and local businesses that can help with your search for information on Dry Eye Syndrome Treatment. You will find informative articles about Dry Eye Syndrome Treatment, including Dry Eye Syndrome Causes And Treatments. Below you will also find local businesses that may provide the products or services you are looking for. Please scroll down to find the local resources in Denver, CO that can help answer your questions about Dry Eye Syndrome Treatment.
This page provides relevant content and local businesses that can help with your search for information on Dry Eye Syndrome Treatment. You will find informative articles about Dry Eye Syndrome Treatment, including Dry Eye Syndrome Causes And Treatments. Below you will also find local businesses that may provide the products or services you are looking for. Please scroll down to find the local resources in South Portland, ME that can help answer your questions about Dry Eye Syndrome Treatment.
Salivary gland tumors are more likely to be cancerous in children when compared to adults. About half of the salivary gland tumors are cancerous in children. Most of the tumors occur in a salivary gland called parotid gland (located at the angle of the jaw below the ear lobes on both sides). The types of cancerous salivary gland tumors include mucoepidermoid carcinoma, adenoid cystic carcinoma, acinic cell carcinoma and adenocarcinoma NOS.. ...
Press Release issued Mar 2, 2015: Clinical trial report, Keratoconjunctivitis sicca (Dry Eye) Global Clinical Trials Review, H1, 2015 provides data on the Keratoconjunctivitis sicca (Dry Eye) clinical trial scenario. This report provides elemental information and data relating to the clinical trials on Keratoconjunctivitis sicca (Dry Eye). It includes an overview of the trial numbers and their recruitment status as per the site of trial conduction across the globe. The databook offers a preliminary coverage of disease clinical trials by their phase, trial status, prominence of the sponsors and also provides briefing pertaining to the number of trials for the key drugs for treating Keratoconjunctivitis sicca (Dry Eye). This report is built using data and information sourced from proprietary databases, primary and secondary research and in-house analysis by GlobalDatas team of industry experts.
Sebaceous lymphadenoma is a benign tumour of the salivary gland. Sebaceous lymphadenoma is a tissue diagnosis, e.g. salivary gland biopsy. It may be confused with a number of benign and malignant neoplasms, including Warthin tumour, mucoepidermoid carcinoma and sebaceous lymphadenocarcinoma. The treatment is simple excision and exclusion of a malignant neoplasm. Lymph node Lymphoma Salivary gland neoplasm Mishra, A.; Tripathi, K.; Mohanty, L.; Nayak, M. "Sebaceous lymphadenoma of the parotid gland". Indian J Pathol Microbiol. 54 (1): 131-2. doi:10.4103/0377-4929.77364. PMID 21393895. While, B.; Whiteside, OJ.; Desai, V.; Gurr, P. (Aug 2010). "Sebaceous lymphadenoma: a case report and review of the literature". Ear Nose Throat J. 89 (8): E22-3. PMID 20737364 ...
Background/Purpose: Mast cells (MCs) are immune cells that produce and secrete a variety of mediators and cytokines, which influence various inflammatory and immune processes. It has become clear that MCs were not only related to allergic reactions, but also involved in several autoimmune diseases. However, the role and precise mechanism of MCs on the pathogenesis of primary Sjogren¡¯s syndrome (pSS) is not completely understood. Leptin is a protein secreted by adipose tissue, which has an important role in metabolism and immunity. MCs were found to express leptin receptors. It is therefore plausible that leptin, through its effects on MCs, may play an important role in the development of pSS. The present study aimed to investigate the distribution of MCs in labial salivary glands in an attempt to elucidate a possible role of MCs in the pSS pathogenesis. Furthermore, this work explored the correlation between MCs and leptin in the pSS. Methods: All recruited patients fulfilled the ...
Cardiolipin Antibodies are seen in a subgroup of patients with autoimmune disorders, particularly Systemic Lupus Erythematosus (SLE), who are at risk for vascular thrombosis, thrombocytopenia, cerebral infarct and/or recurrent spontaneous abortion. Elevations of associated with increased risk have also been seen in idiopathic thrombocytopenic purpura, rheumatoid and psoriatic arthritis, and primary Sjogrens syndrome ...
Canalicular adenoma is a type of benign salivary gland tumor that occurs most often in minor salivary glands. In addition to pleomorphic adenoma, the two are the most common tumors of the upper lip. In 95% of cases, canalicular adenoma occurs on the upper lip. The next most common location is the buccal mucosa (inner cheek). Other sites of the mouth, including the parotid gland, are rare for this disease. Canalicular adenoma is most likely to occur in older adults around 70 years of age. There is a predilection for gender with most cases being in females. Canalicular adenoma is characterized as a slow growing, painless swelling, whose diameter can be up to 2 cm. It can be normal or bluish in color. The appearance of this tumor microscopically is very distinct. There are cords of columnar or cuboidal epithelium, which have basophillic nuclei. Parallel rows of cords appear to form long canals. Frequently, there are large cystic spaces. There are no stromal alterations evident. Treatment usually ...
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Objectives: The objectives of this study were to investigate the feasibility of clinical application of magnetic resonance (MR) virtual endoscopy as a presurgical procedure before sialoendoscopy and to evaluate its value in the diagnosis of obstructive salivary gland diseases and preoperative visualization of endoluminal views.. Study Design: This study presents our initial experience to use MR virtual endoscopy for the presurgical visualization of salivary duct lumen and ductal pathologies in comparison to the sialoendoscopy findings in a feasibility study.. Methods: Six consecutive patients with suspected obstructive salivary gland diseases underwent MR sialography with a three-dimensional fast imaging using steady-state acquisition. The three-dimensional MR data were transferred to an independent workstation and were postprocessed with navigator software to generate three-dimensional reconstruction and virtual endoscopic images. The fly-through mode was used to imitate the sialoendoscopic ...
TY - JOUR. T1 - Radiologic manifestations of the systemic autoimmune diseases. AU - Primack, Steven. AU - Muller, N. L.. PY - 1998. Y1 - 1998. N2 - Advances in thoracic imaging during the past two decades, such as CT scans and MR imaging, have enhanced our understanding of the pleuropulmonary abnormalities that develop in the systemic autoimmune diseases. In this article, the thoracic radiologic manifestations of several connective tissue diseases (systemic lupus erythematosus, rheumatoid arthritis, Sjogrens syndrome, polymyositis/dermatomyositis, progressive systemic sclerosis, and anklyosing spondylitis), two granulomatous vasculitides, (Wegeners Granulomatosis and Churg-Strauss syndrome), and antiglomerular basement membrane disease are reviewed.. AB - Advances in thoracic imaging during the past two decades, such as CT scans and MR imaging, have enhanced our understanding of the pleuropulmonary abnormalities that develop in the systemic autoimmune diseases. In this article, the thoracic ...
Salivary gland diagnostics. Salivary gland X-ray (sialography) of a human head, showing the submandibular gland. This is a paired salivary gland found below the lower jaw bone (mandible). Here, a contrast medium has been injected to show the salivary ducts which secrete saliva. This can be done to diagnose certain disorders. - Stock Image C010/5967
To the Editor:. A 60-year-old woman was seen at the outpatient clinic of the Department of Rheumatology because of increased complaints of xerophthalmia. In 1997, she had already been diagnosed with Sjögrens syndrome (SS) based on xerophthalmia, xerostomia, bilateral salivary gland swelling, and positive sialography showing chronic inflammation without local obstruction. Antinuclear antibodies (ANA) and anti-SSA/SSB were negative. Because of persistent progressive salivary gland swelling at that time, a total bilateral submandibular gland excision was performed as development of non-Hodgkin lymphoma as a complication of SS was suspected. Histology showed sialoadenitis as seen in SS without signs of lymphoma. In 2002, a renal biopsy performed because of increased creatinine level without proteinuria revealed focal global glomerulosclerosis with interstitial nephritis due to SS or chronic ischemia. In an attempt to treat possible active interstitial nephritis due to SS, she was treated with 30 ...
Purpose: Farming has been previously associated with the autoimmune rheumatic diseases (ARD), including rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The exposure(s) underlying this association are not well-understood, and few studies have directly addressed the role of pesticides, including personal and residential insecticide use. Method: Using data from the Womens Health Initiative Observational Study (n=76,861, aged 50-79 years), we examined self-reported lifetime personal or commercial residential insecticide use and having lived or worked on a farm in relation to risk of incident ARD, confirmed by use of disease modifying anti-rheumatic drugs at year 3 of follow-up (n=213; 178 with RA only, 27 with SLE only, and 8 with both RA and SLE), and excluding unconfirmed cases. Hazard ratios (HR) and 95% confidence intervals (CI) were estimated by multivariate models adjusting for age and covariates, including race, region, education, occupation, history of smoking, asthma, ...
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. It is not yet known whether radiation therapy is more effective when given together with chemotherapy or alone after surgery in treating salivary gland tumors.. PURPOSE: This randomized phase II/III trial is studying radiation therapy with or without chemotherapy to see how well it works in treating patients with high-risk malignant salivary gland tumors that have been removed by surgery. ...
Dry eye syndrome is an extremely common condition that causes dry, itchy, red and gritty feeling eyes and blurred vision. Dry eye syndrome can occur due to computer and mobile device use, hormonal change, age, allergies, environment, meibomian gland dysfunction and rosacea. Many treatments are available for this condition, although some people may experience chronic dry eye symptoms. Lubricating eye drops will offer temporary relief but dry eye syndrome progressively worsens with age and eye usage. A detailed evaluation is required for all the different tear glands and allergies to diagnose dry eye syndrome accurately.. More about Dry Eye Syndrome. ...
Purpose: To evaluate the clinical and histopathological safety of a gellan gum/sodium hyaluronate based new artificial tear, when applied to rabbit eyes.. Methods: Thirty healthy male New Zealand White rabbits (60 eyes) were included in this study. The preservative free gellan gum 0.35%/ sodium hyaluronate 0.5% ophthalmic solution was applied 4 times a day for 30 days in both eyes. Slit lamp examination (conjunctival hyperemia, chemosis and conjunctival discharge evaluation) and corneal staining were performed on days 2, 5, 10, 15, 20, 25 and 30 of the study. On day 31 rabbits were sacrificed and enucleated for hysthopathological assessment.. Results: Conjunctival hyperemia, graded minimal or mild, was encountered through all the evaluations, being statistically significant compared with baseline (p,0.05), reaching its highest peak on day 20, with 36.7% (n= 22). On day 2, conjunctival discharge was present in 8.3% (n=5), also reaching a statistically significant difference compared with ...
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Figure 34.3 Diagram of the relationships between the lingual artery and nerve, submandibular duct, hypoglossal nerve and muscle ...
Patient may present with diffuse and ill defined swelling over the region of parotid gland. The sites of parotid swelling is tender to touch in acute case, stones may be palpable in the parotid duct and pus may be expressed form the parotid duct.