In medicine, the Sister Mary Joseph nodule or more commonly node, also called Sister Mary Joseph sign, refers to a palpable nodule bulging into the umbilicus as a result of metastasis of a malignant cancer in the pelvis or abdomen. Sister Mary Joseph nodules can be painful to palpation. A periumbilical mass is not always a Sister Mary Joseph nodule. Other conditions that can cause a palpable periumbilical mass include umbilical hernia, infection, and endometriosis. Medical imaging, such as abdominal ultrasound, may be used to distinguish a Sister Mary Joseph nodule from another kind of mass. Gastrointestinal malignancies account for about half of underlying sources (most commonly gastric cancer, colonic cancer or pancreatic cancer, mostly of the tail and body of the pancreas), and men are even more likely to have an underlying cancer of the gastrointestinal tract. Gynecological cancers account for about 1 in 4 cases (primarily ovarian cancer and also uterine cancer). Nodules will also, rarely, ...
Umbilical hernia repair - MedHelps Umbilical hernia repair Center for Information, Symptoms, Resources, Treatments and Tools for Umbilical hernia repair. Find Umbilical hernia repair information, treatments for Umbilical hernia repair and Umbilical hernia repair symptoms.
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Umbilicus rupestris (Navelwort, Penny-pies, Wall Pennywort) is a fleshy, perennial, edible flowering plant in the stonecrop family Crassulaceae (in the genus Umbilicus) so named for its umbilicate (navel-like) leaves. Wall pennywort grows to an average of 25 cm (9.8 in) high. The pallid spikes of bell-shaped, greenish-pink flowers of this plant first appear in May, and the green fruits ripen through the summer. Both the name "navelwort" and the scientific name Umbilicus come from the round shape of the leaves, which have a navel-like depression in the center. The plant is found in southern and western Europe, often growing on shady walls or in damp rock crevices that are sparse in other plant growth (thus, "wall" pennywort), where its succulent leaves develop in rosettes. It is not at present under threat. Umbilicus rupestris is not the same "Pennywort" as the one used in Asian medicine, which is the unrelated Asiatic Pennywort, Centella asiatica. Umbilicus rupestris is used in homeopathic ...
Patient testimonials help you to learn more about colorectal surgeon Dr Massimo Cristaldi in Abu Dhabi, UAE, and his umbilical hernia surgery and colonoscopy procedure.
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Detection of scientific misconduct in publishing is often the result of the alertness of coworkers and/or other authors of the same manuscript, and much less commonly by editors, peer reviewers, or readers. If an allegation of scientific misconduct is made in relation to a manuscript under consideration or published, the editor has a duty to ensure confidential and timely pursuit of that allegation. According to the International Committee of Medical Journal Editors (ICMJE),
Tumefactions of the groin and umbilicus - Pediatric Surgery. Tumefactions of the groin and umbilicus - Pediatric Surgery Tumefactions of the Groin and Umbilicus . Inguinal and Umbilical Hernia . click the images for more details Incidence.Illustrations Inguinal and umbilical hernias belong to the most frequent surgical lesions in the first year of life. 1 to 4 percent of the younger children are involved, mostly boys. show details Clinical significance. 1. Very common lesion. 2. Danger of incarceration with damage to the testicle and the intestine. 3. If untreated, cause of recurrent pain in the groin. Etiology.Illustrations A patent processus vaginalis which does not obliterate after testicular descent and additional factors contribute to a clinically apparent congenital inguinal hernia. In contrast to the adult type of inguinal hernia with a hernia sac originating medially of the epigastric vessels due to a weakness of the abdominal wall, in congenital inguinal hernia the hernia sac originates ...
Looking for online definition of left gastric artery in the Medical Dictionary? left gastric artery explanation free. What is left gastric artery? Meaning of left gastric artery medical term. What does left gastric artery mean?
Soaking in a heat bathtub may help alleviate some discomfort, and take into account sleeping in a comfortable bra. Theyre an amazing supply stomach muscle stretch after pregnancy knowledge and support if you happen tore ever uncertain of something during your being pregnant. Muscle-strengthening activity can include climbing stairs, strolling uphill, lifting or carrying procuring, weight training, yoga or related emerency child birth workout routines that stomach muscle stretch after pregnancy your major muscle teams. Week fourteen ought to be the week in which youll be able to stomach muscle stretch after pregnancy the newborns heartbeat throughout your visit to your obstetrician. As stomach muscle stretch after pregnancy as my miscarriage cleared up from last month, we instantly began trying once more. You might also find that the bumps around your nipples turn into more pronounced or your nipples are extra erect. It is rather tough to conduct a legitimate scientific examine of marijuanas ...
Natural orifice transluminal endoscopic surgery (NOTES) is a new surgical technique, which consists in reaching the peritoneal cavity through a natural orifice (mouth, anus, or vagina) in order to...
Masao Fujiwara, MDPhD, Hirohito Mori, MDPhD, Yuji Nishizawa, MDPhD, Akihiro Kondo, MD, Keiichi Okano, MDPhD, Tsutom Masaki, MDPhD, Yasuyuki Suzuki, MDPhD. Department of Gastroenterological Surgery and Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Kagawa, Japan.. Natural orifice transluminal endoscopic surgery (NOTES) is a minimally invasive surgery, but the procedures using only a flexible endoscope are technically demanding. We have performed hybrid NOTES with laparoscope-assisted endoscopic full-thickness resection for 14 patients with a gastric gastrointestinal stromal tumor (GIST). Briefly, the tumor is resected with a full-thickness gastric wall endoscopically with the aid of a laparoscope. Then, suture closure of the stomach is completed laparoscopically. The specimen is usually removed through the mouth. All the tumors were resected en bloc with a negative surgical margin. Histologically, 3 cases were classified in the high-risk group, 2 in the ...
The term gossypiboma denotes a mass of cotton that is retained in the body following surgery. Gossypiboma is a medico-legal problem especially for surgeons. To the best of our knowledge, the patient presented herein is the second reported patient in whom the exact site of migration of a retained surgical textile material into the intestinal lumen could be demonstrated by preoperative imaging studies. A 74-year-old woman presented with symptoms of small bowel obstruction due to incomplete intraluminal migration of a laparotomy towel 3 years after open cholecystectomy and umbilical hernia repair. Plain abdominal radiography did not show any sign of a radio-opaque marker in the abdomen. However, contrast enhanced abdominal computerized tomography revealed a round, well-defined soft-tissue mass with a dense, enhanced wall, containing an internal high-density area with air-bubbles in the mid-abdomen. A fistula between the abscess cavity containing the suspicious mass and gastrointestinal tract was
Covert duplicate publication violates the ethics of scientific publishing and may constitute a violation of copyright law. Editors have a duty to inform prospective authors of their policies on duplicate publication, which should be published in their instructions for authors. Reviewers should notify editors of the existence of duplicate articles discovered during their review. Authors should send copies of all duplicate or overlapping articles and manuscripts with their submitted manuscripts. Authors should also include citations to highly similar articles and any reports from the same study under their authorship in the reference list of the submitted manuscript. When in doubt
Global Hernia Repair Devices and Consumables Market Size, Status and Forecast 2022. 1 Industry Overview of Hernia Repair Devices and Consumables. 1.1 Hernia Repair Devices and Consumables Market Overview. 1.1.1 Hernia Repair Devices and Consumables Product Scope. 1.1.2 Market Status and Outlook. 1.2 Global Hernia Repair Devices and Consumables Market Size and Analysis by Regions. 1.2.1 United States. 1.2.2 EU. 1.2.3 Japan. 1.2.4 China. 1.2.5 India. 1.2.6 Southeast Asia. 1.3 Hernia Repair Devices and Consumables Market by Type. 1.3.1 Incisional hernia. 1.3.2 Inguinal hernia. 1.3.3 Femoral hernia. 1.3.4 Umbilical hernia. 1.3.5 Others. 1.4 Hernia Repair Devices and Consumables Market by End Users/Application. 1.4.1 Open tension-free repair. 1.4.2 Laparoscopic surgery. ….Continued. View Detailed Table of Content @ https://www.htfmarketreport.com/reports/724804-global-hernia-repair-devices-and-consumables-market. Thanks for reading this article, you can also get individual chapter wise section or ...
Smooth muscle is responsible for the contractility of hollow organs, such as blood vessels, the gastrointestinal tract, the bladder, and the uterus. Its structure differs greatly from that of skeletal muscle. The human stomach contains three layers of muscle in its walls, the outer longitudinal, the middle circular and the inner oblique and visceral smooth muscle cells makes up all three layers along the entire organ. Smooth muscle contraction is critical to peristalsis in the human stomach and the contraction may be mediated by activation of phospholipase through two distinct mechanisms (increased intracellular Ca2+ and G protein activation) and activating PKCepsilon-dependent mechanisms. In vitro study also shows that gastric smooth muscle cells express ET and eNOS and both calcium and sodium may be involved as current carriers in the generation of the plateau potential.HGSMC from Bioarray Research Laboratories are isolated from the human stomach. HGSMC are cryopreserved at secondary culture ...
Digital Archiving: Journal Repository (JR) The aim of Asian Journal of Biology (ISSN: 2456-7124) is to publish high quality papers (Click here for Types of paper) with broad areas of Aerobiology, Agriculture, Anatomy, Astrobiology, Biochemistry, Bioengineering, Bioinformatics, Biomathematics or Mathematical Biology, Biomechanics, Biomedical research, Biophysics, Biotechnology, Building biology, Botany, Cell biology, Conservation Biology, Cryobiology, Developmental biology, Food biology, Ecology, Embryology, Entomology, Environmental Biology, Epidemiology, Ethology, Evolutionary Biology, Genetics, Herpetology, Histology, Ichthyology, Integrative biology, Limnology, Mammalogy, Marine Biology, Microbiology, Molecular Biology, Mycology, Neurobiology, Oceanography, Oncology, Ornithology, Population biology, Population ecology, Population genetics, Paleontology, Pathobiology or pathology, Parasitology, Pharmacology, Physiology, Psychobiology, Sociobiology, Structural biology, Virology and Zoology. ...
Looking for online definition of Plateau, Joseph Antoine Ferdinand in the Medical Dictionary? Plateau, Joseph Antoine Ferdinand explanation free. What is Plateau, Joseph Antoine Ferdinand? Meaning of Plateau, Joseph Antoine Ferdinand medical term. What does Plateau, Joseph Antoine Ferdinand mean?
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Find inspiration with the gastric bypass surgery story of Sister Mary Catherine Stana, courtesy of the University of Pittsburgh Medical Center.
Raymund Andrew G Ong, MD FPCS FPALES, Winston S Vequilla, MD DPBS. Department of Surgery, FEU-NRMF Medical Center, Philippines. Objectives: Laparoscopic cholecystectomy has replaced open cholecystectomy as the standard procedure for gallbladder removal whenever possible. Recent developments regarding laparoscopic cholecystectomy have been directed toward reducing the size or number of ports to achieve the goal of minimally invasive surgery. The first successful case of single port access (SPA) Laparoscopic Cholecystectomy in the Philippines was done at FEU-NRMF Medical Center in August 2008 and became almost the standard in the surgery of the gallbladder. The goal of this prospective randomized controlled clinical study is to evaluate the real benefit of single port access as compared to standard three-port technique without compromising the safety in cases of laparoscopic cholecystectomy in terms of pain, recovery, and patient satisfaction ...
Mucopolysaccharidosis type VII (MPS VII), also known as Sly syndrome, is a progressive condition that affects most tissues and organs. The severity of MPS VII varies widely among affected individuals.. The most severe cases of MPS VII are characterized by hydrops fetalis, a condition in which excess fluid builds up in the body before birth. Most babies with hydrops fetalis are stillborn or die soon after birth. Other people with MPS VII typically begin to show signs and symptoms of the condition during early childhood. The features of MPS VII include a large head (macrocephaly), a buildup of fluid in the brain (hydrocephalus), distinctive-looking facial features that are described as "coarse," and a large tongue (macroglossia). Affected individuals also frequently develop an enlarged liver and spleen (hepatosplenomegaly), heart valve abnormalities, and a soft out-pouching around the belly-button (umbilical hernia) or lower abdomen (inguinal hernia). The airway may become narrow in some people ...
The Beckwith-Wiedemann syndrome, originally described by Beckwith in 1963 and Wiedemann in 1964, included congenital anomalies such as macroglossia, exomphalos, postnatal somatic gigantism, severe hypoglycemia, abdominal wall defect, capillary nevus flameus and hemihypertrophy. Macroglossia is the most common manifestation of Beckwith-Wiedemann syndrome, with studies reporting between 82 and 95 percent of the cases. Macroglossia may cause the upper airway obstruction, deglutition difficulty, articulation interference and protrusion of dentoalveloar structures resulting in anterior open bite and a mandibular prognathism. We experienced a 5 month-old male with upper airway obstruction, deglutition difficulty and recurrent upper airway infection due to macroglossia associated with Beckwith-Wiedemann syndrome and significant improvement in respiration, feeding and oral competence at 14 months follow-up after rhomboid resection and primary closure of tongue. ...
John Frederick Long, whose life revolved around family, education, science, and a love of learning, died July 20, 2009 at the age of 85. John Long was born in Napoleon, Ohio, May 30, 1924. John grew up in a loving home that included his parents George Emerson and Emily Lynas Long, his older sister Mary and his paternal grandparents John Armel and Elizabeth Nyswander Long. John left home in 1942 to begin college at The Ohio State University but was diverted by World War II, spending three years in the Army Medical Corps. When the war ended, he returned to Ohio State, which was to provide him with a life-long academic home. He earned a bachelors degree in Biological Sciences in 1947, a Masters in Zoology in 1948 and a Doctor of Veterinary Medicine degree in 1955. After working as a diagnostic pathologist at the Animal Disease Diagnostic Laboratory at Reynoldsburg, he returned to Ohio States College of Veterinary Medicine to complete his PhD in veterinary pathology in 1966. John joined the Ohio ...
Take the Bible: Zechariah and Elizabeth, for instance. Zechariah was extremely old to marry Elizabeth and they became the parents of John the Baptist. Also take Joseph and Mary. Mary was a teenager and Joseph was an adult carpenter. They became parents of Jesus. Theres just nothing immoral or illegal here. Maybe just a little bit unusual.". Thats how the Alabama state auditor defended U.S. Senate candidate Roy Moore as some eight middle-aged Alabama women came forward to accuse Moore of sexually harassing or stalking them when he was 30-something and they were teenagers, the youngest and most graphic at age 14.. Welcome to Advent in America, 2017. Advent, those four weeks before Christmas when Christians declare that "the word became flesh and dwelt among us," is the churchs witness to Christs incarnation, and against our cultures ceaseless effort to Christianize Black Friday materialism. This Advent, however, the Jesus Story has been sordidly deployed in defense of a political candidate ...
Magnified intelligence chromoendoscopy (FICE) plus probe-based confocal laser endomicroscopy (pCLE) for Gastric Intestinal Metaplasia (GIM) diagnosis: a feasibility trial. Research Question:. Is confocal endomicroscope feasible to diagnose gastric intestinal metaplasia?. Objective:. To evaluate the feasibility of confocal endomicroscope in diagnose gastric intestinal metaplasia.. Hypothesis:. Confocal endomicreosocpe can provide the accurate diagnosis of gastric intestinal metaplasia.. Research design:. Diagnostic study. Sample size:. The investigators follow the population in recent study from Imraporn et al.: Validity of magnify NBI for gastric intestinal metaplasia targeted biopsy (N= 50). Data analysis:. Confocal Barretts esophagus classification was used to evaluate agreement of confocal endomicroscopic finding in gastric intestinal metaplasia. The accuracy of new criteria for GIM by confocal endomicroscope was evaluated in relation to pathological report, a gold standard for diagnosis, ...
Dept. of Biological Sciences. Paper copy at Leddy Library: Theses & Major Papers - Basement, West Bldg. / Call Number: Thesis1981 .B372. Source: Masters Abstracts International, Volume: 40-07, page: . Thesis (M.Sc.)--University of Windsor (Canada), 1981.
Abdominoplasty - Abdominal correction: Tightening the stomach muscles. Cosmetic Surgery Belgium, Europe. Abdominoplasty Info, risks & pictures. Abdominoplasty costs and prices: Quality Certified Plastic surgery Hospital.
TY - JOUR. T1 - Effects of GC7101, a novel prokinetic agent on gastric motor function. T2 - Ex vivo study. AU - Jung, Da Hyun. AU - Choi, Eun Ju. AU - Jeon, Han Ho. AU - Lee, Young Ho. AU - Park, Hyojin. PY - 2014/1/1. Y1 - 2014/1/1. N2 - Background/Aims: GC7101, an extract of Lonicera Flos, is a novel developing drug for reflux esophagitis and functional dyspepsia. However, the drugs exact pharmacological mechanism of action remains unclear. This study assessed the effects of GC7101 on gastrointestinal (GI) motor function. Methods: We used male guinea pigs to evaluate the effects of GC7101 on GI motility. The contraction of antral circular muscle in the presence of different doses of GC7101 was measured in a tissue bath. The prokinetic effects of GC7101 were tested using the charcoal transit assay from the pylorus to the most distal point of migration of charcoal mixture. To clarify the mechanism of action of GC7101, atropine, dopamine and the selective 5-hydroxytryptamine 4 receptor ...
TY - JOUR. T1 - Prenatal diagnosis of omphalocele and left atrial isomerism (Polysplenia) including complex congenital heart disease with ventricular noncompaction cardiomyopathy. AU - Boe, Nina. AU - Rhee-Morris, Laila. AU - Towner, Dena. AU - Moon-Grady, Anita J.. PY - 2008/7. Y1 - 2008/7. UR - http://www.scopus.com/inward/record.url?scp=47249152778&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=47249152778&partnerID=8YFLogxK. M3 - Article. C2 - 18577680. AN - SCOPUS:47249152778. VL - 27. SP - 1117. EP - 1121. JO - Journal of Ultrasound in Medicine. JF - Journal of Ultrasound in Medicine. SN - 0278-4297. IS - 7. ER - ...
TY - JOUR. T1 - Long-term effects of jejunoileal autotransplantation on myoelectrical activity in canine small intestine. AU - Quigley, Eamonn M M. AU - Spanta, Ali D.. AU - Rose, Scott G.. AU - Lof, John. AU - Thompson, Jon S. PY - 1990/12/1. Y1 - 1990/12/1. N2 - We studied the longitudinal effects of autotransplantation on the motor function of the jejunoileum. By performing the autotransplantation procedure in a manner similar to that employed for allotransplantation, we sought to examine the long-term effects of both extrinsic denervation and the operative procedure itself on small intestinal motor function. Although initially disrupted, interdigestive myoelectrical activity demonstrated progressive organization: 88% of migrating myoelectrical complexes in animals studied between 12 and 20 months following autotransplantation demonstrated each phase of the complex in normal sequence. Longitudinal studies of several parameters of myoelectrical activity provided further evidence of progressive ...
The SAGES Manual of Hernia Repair will serve as a state-of-the-art resource for hernia surgeons and residents alike who are interested in the rapidly evolving area of abdominal wall hernia repair. This manual captures and summarizes the current trends in the field, as well as describing the new ideas, programs, and strategies regarding hernia repair. Through a unique section called Current Debates in Inguinal Hernia Repair, this volume also provides readers an overview of the current opinions on many of the ongoing debates of this time period. Furthermore, the manual is lavishly illustrated, containing an array of instructional charts and photographs, and is authored by a panel of experts in hernia repair.. Comprehensive and easily accessible, The SAGES Manual of Hernia Repair is a portable reference that will be of great value to all practicing surgeons and residents working in the field of abdominal wall hernia repair. ...
Joseph Brown, Jr. (Buddy Brown), a Personal Injury Lawyer in Mobile Alabama, is an extremely accomplished trial lawyer and a member of the Inner Circle of Advocates. He is listed in Benchmark Litigation as one of the Top 100 Trial Lawyers in America, Lawdragons 500 Leading Lawyers in America and was named to Lawdragons 500 Leading Plaintiffs Lawyers (2007). Benchmark Plaintiff lists him as a Litigation Star in its national rankings of personal injury attorneys. Joseph M. Brown has obtained dozens of multi-million dollar verdicts and settlements for his clients, and continues today in his representation and advocacy on behalf of his clients in cases of Personal Injury, General Negligence, Products Liability, Insurance Fraud, Bad Faith, Medical Malpractice, Admiralty / Maritime, and Aviation.
2. The flame retardant poly(arylene ether) resin composition according to claim 1, wherein the poly(arylene ether) resin is one or more selected from poly(2,6-dimethyl-1,4-phenylene ether), poly(2,6-diethyl-1,4-phenylene ether), poly(2-methyl-6-ethyl-1,4-phenylene ether), poly(2-methyl-6-propyl-1,4-phenylene ether), poly(2,6-dipropyl-1,4-phenylene ether), poly(2-ethyl-6-propyl-1,4-phenylene ether), poly(2,6-dimethoxy-1,4-phenylene ether), poly(2,6-di(chloromethyl)-1,4-phenylene ether), poly(2,6-di(bromomethyl)-1,4-phenylene ether), poly(2,6-diphenyl-1,4-phenylene ether), poly(2,6-dichloro-1,4-phenylene ether), poly(2,6-dibenzyl-1,4-phenylene ether) and poly(2,5-dimethyl-1,4-phenylene ether ...
1. WahleE (1991) A novel poly(A)-binding protein acts as a specificity factor in the second phase of messenger RNA polyadenylation. Cell 66: 759-768.. 2. KuhnU, NemethA, MeyerS, WahleE (2003) The RNA binding domains of the nuclear poly(A)-binding protein. J Biol Chem 278: 16916-16925.. 3. KerwitzY, KuhnU, LilieH, KnothA, ScheuermannT, et al. (2003) Stimulation of poly(A) polymerase through a direct interaction with the nuclear poly(A) binding protein allosterically regulated by RNA. Embo J 22: 3705-3714.. 4. KuhnU, GundelM, KnothA, KerwitzY, RudelS, et al. (2009) Poly(A) tail length is controlled by the nuclear poly(A)-binding protein regulating the interaction between poly(A) polymerase and the cleavage and polyadenylation specificity factor. J Biol Chem 284: 22803-22814.. 5. KuhnU, WahleE (2004) Structure and function of poly(A) binding proteins. Biochim Biophys Acta 1678: 67-84.. 6. ApponiLH, LeungSW, WilliamsKR, ValentiniSR, CorbettAH, et al. (2010) Loss of nuclear poly(A)-binding protein 1 ...
An umbilical hernia is a bulge near the belly button, or navel. Intestines or other tissues may bulge through an opening or a weak spot in the stomach muscles. The hernia has a sac that may hold some intestine, fat, or fluid. A baby can be born with a hernia. But parents may not notice it until the umbilical cord stump falls off, which may be a few days to a couple of weeks after birth. Usually, umbilical hernias are not painful or dangerous.. Most umbilical hernias close on their own without treatment, usually in a babys first year or by age 4 or 5 years. A child usually needs surgery only if the hernia is very large or has not gone away by the time the child is 4 or 5. While you wait for the hernia to close, watch for signs of any problems. In rare cases, the hernia can trap some of the intestine and cut off its blood supply. If this happens, your baby needs treatment right away. ...
Acid reflux is caused by stomach fluid, which contains strong digestive acids to break down food, leaking out of the stomach and travelling up toward the oesophagus.. Jan 23, 2017. Heartburn, also known as indigestion, can be triggered by eating too much food, or as a result of GORD - gastro-oesophageal reflux disease.. Many patients with gastroesophageal reflux disease (GERD) will experience heartburn, while those with a stomach ulcer may notice a constant burning, g.. Heartburn is caused by peptic ulcers, sores on the lining of the stomach or. Both the acid and the bacteria irritate the lining and cause a sore, or ulcer. H. pylori.. Esophageal ulcers: Symptoms, causes, and treatment - Aug 6, 2017. Esophageal ulcers are a type of peptic ulcer that develops between the throat and the stomach. Using medications, bodily infections, and exposure to stomach acid are the. In cases of acid reflux, treatment may include:.. Recently, some friends asked me for home remedies for acid reflux, so it ...
Duodenal biopsy specimens from 80 patients with chronic renal failure, who were undergoing haemodialysis, were examined by light microscopy for evidence of inflammation, gastric metaplasia, and Campylobacter pylori infection. Chronic duodenitis was present in 47 (59%) of patients, of whom only seven (9%) showed evidence of active inflammation. Gastric metaplasia was present in 50 (62.5%) of patients, yet Campylobacter pylori was identified in only two patients (2.5%). It is suggested that the duodenal environment of patients with chronic renal failure remains hostile to the growth of these organisms in spite of the presence of gastric metaplasia.. ...
Degradation of mRNA is a highly regulated step important for proper gene expression. Degradation of eukaryotic mRNA is initiated by shortening of the 3 end located poly(A) tail. Poly(A)-specific ribonuclease (PARN) is an oligomeric enzyme that degrades the poly(A) tail with high processivity. A unique property of PARN is its ability to interact not only with the poly(A) tail but also with the 5 end located mRNA cap structure. A regulatory role in protein synthesis has been proposed for PARN based on its ability to bind the cap that is required for efficient initiation of eukaryotic mRNA translation. Here we have investigated how the cap structure influences PARN activity and how PARN binds the cap. We show that the cap activates PARN and enhances the processivity of PARN. Further we show that the cap binding complex (CBC) inhibits PARN activity through a protein-protein interaction. To investigate the cap binding property of PARN, we identified the cap binding site at the molecular level using ...
How to Play Pin the Tail on the Donkey. Pin the Tail on the Donkey is a classic childrens game, often associated with birthday parties. Easy to play and fun for all ages, Pin the Tail on the Donkey costs next to nothing to play. As an...
Polyadenylated and nonpolyadenylated mRNA were prepared from polysomes and from the postribosomal supernatant of noninduced and DMSO-induced Friend cells. The mRNA preparations were translated in a wheat germ cell-free system and the in vitro synthesized proteins, fractionated by polyacrylamide gel electrophoresis, were compared by fluorography. The electrophoretic analysis shows that four preparations of poly (A) + RNA code for many different peptides and that most of these peptides are present in each of the poly (A) + RNA translation products. However, the electrophoretic patterns of these translation products differ in the relative amounts of peptides comigrating in the gel electrophoresis. After DMSO treatment, Friend cells show significative differences in the polysomal and nonpolysomal mRNA pools. With induction, globin becomes the most abundant product of the polysomal poly (A) + RNA, while the relative amounts of peptides coded by nonglobin polysomal poly (A) + RNA are reduced. In ...
Arabidopsis mRNA polyadenylation machinery: comprehensive analysis of protein-protein interactions and gene expression profiling. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
TY - JOUR. T1 - Ulcer site and complications. T2 - Relation to Helicobacter pylori infection and NSAID use. AU - Al-Assi, M. T.. AU - Genta, R. M.. AU - Karttunen, T. J.. AU - Graham, D. Y.. PY - 1996/2. Y1 - 1996/2. N2 - Background and Study Aim: The aim of this study was to investigate the relationship between the presence and location of ulcers, H. pylori infection, NSAID use, and major upper gastrointestinal tract bleeding. Patients and Methods: We studied 100 consecutive patients with duodenal ulcers and 145 consecutive patients with benign gastric ulcers. Results: Ninety-nine percent of the duodenal ulcer patients and 92% of the gastric ulcer patients had H. pylori infection; all gastric ulcer patients without H. pylori infection were using NSAIDs. Gastric ulcers in patients with H. pylori infection who were not using NSAIDs were more likely to be on the lesser curvature (85%) than ulcers in NSAID users who had no H. pylori infection (36%) (p , 0.01). Conversely, only 5% of gastric ulcers ...
AtCPSF30 is the only Arabidopsis protein with a degree of sequence similarity to other eukaryotic CPSF30 proteins that extends beyond the typical spacing of Cys and His residues in the CCCH zinc-finger motif, and a number of lines of evidence support the conclusion that AtCPSF30 is an authentic polyadenylation factor subunit. As is the case with its yeast counterpart (Yth1p; Barabino et al., 1997), AtCPSF30 interacts with another Arabidopsis polyadenylation subunit homolog, AtFip1(V) (Forbes et al., 2006); AtFip1(V) also interacts with poly(A) polymerase and thereby provides a conceptual link between AtCPSF30 and poly(A) polymerase. The results presented in this study show that AtCPSF30 is present in the nucleus (Fig. 2B), as would be expected of a polyadenylation factor subunit. The coimmunoprecipitation of AtCPSF30 by antibodies raised against AtCPSF100 (Fig. 2C) indicates that AtCPSF30 resides, at least in part, in a complex with another Arabidopsis polyadenylation factor subunit. AtCPSF30 is ...
This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. This particular collagen IV subunit, however, is only found in a subset of basement membranes. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. Mutations in this gene are associated with type II autosomal recessive Alport syndrome (hereditary glomerulonephropathy) and with familial benign hematuria (thin basement membrane disease). Two transcripts, differing only in their transcription start sites, have been identified for this gene and, as is common for collagen genes, multiple polyadenylation sites are found in the 3 UTR ...
Summary Joseph Torkildson, MD, is an expert in neuro-oncology, the treatment of central nervous system malignancies. He diagnoses and treats children with benign and malignant brain and spinal cord tumors. One of his major interests is identifying new treatment methods that can improve survival rates while reducing long-term complications often associated with current therapies. For example, he recently began collaborating with the Head Start Consortium: its conducting clinical studies to see if aggressive chemotherapy and stem cell transplantation can replace radiation therapy in the treatment of malignant brain tumors in children. Compelling Fact Brain cancer and tumors are among the most common types of childhood cancers. Nearly one fourth of brain tumors in children are primitive neuroectodermal tumors. When these tumors arise in the cerebellum, they are called medulloblastomas. About 15 percent of childhood brain tumors are medulloblastomas, which are fast-growing tumors that spread along ...
September 27, 2011-New York, NY)-The Autism Science Foundation (ASF), a nonprofit organization dedicated to supporting and funding autism research, today announced that two additional autism scientists had joined its Scientific Advisory Board (SAB). The new members are Dr. Joseph Buxbaum, Director of the Seaver Autism Center and Professor at Mount Sinai School of Medicine, and Dr. Bryan King, Professor of Psychiatry and Behavioral Sciences at the University of Washington and a Research Affiliate at the Center on Human Development and Disability (CHDD).. ASFs SAB is responsible for guiding the organizations scientific direction. SAB members also serve on the review committee for ASFs research grants. Since its founding two years ago, ASF has distributed almost $500,000 in autism research grants and fellowships.. "Dr. Buxbaum and Dr. King are highly respected members of the autism research community and have been active in our grant review process and other science activities," said Alison ...
Dr. Joseph OConnell believes that the aesthetics of breast shape are more important than merely size. Our goal at Plastic Surgery of Southern Connecticut is to help our patients achieve their personal aesthetic goals with regard to the appearance of their breasts by emphasizing proportion, shape, and long-term safe outcomes. With over 20 years of experience encompassing thousands of breast procedures, Dr. OConnell will guide you through the process of breast augmentation, breast lifting or breast reduction. Principles of tissue-based planning are utilized for breast augmentation along with "try-ons" to assist you in your choice of breast implants. Breast surgery is performed almost always on an outpatient basis.. ...
A hernia develops when tissue bulges through a weak spot in the wall of your belly. The groin area and the navel are common areas for a hernia. A hernia can also develop near the area of a surgery you had before.. Pressure from lifting, straining, or coughing can tear the weak area, causing the hernia to bulge and be painful.. If you cannot push a hernia back into place, the tissue may become trapped outside the belly wall. If the hernia gets twisted and loses its blood supply, it will swell and die. This is called a strangulated hernia. It usually causes a lot of pain. It needs treatment right away.. Some hernias need to be repaired to prevent a strangulated hernia. If your hernia causes symptoms or is large, you may need surgery. ...
Cleavage factor Im (CFIm) is one of six factors necessary for correct cleavage and polyadenylation of pre-mRNAs. CFIm is composed of three different subunits of 25, 59, and 68 kDa, and it functions as a heterotetramer, with a dimer of the 25 kDa subunit binding to two of the 59 or 68 kDa subunits. The protein encoded by this gene represents the 59 kDa subunit, which can interact with the splicing factor U2 snRNP Auxiliary Factor (U2AF) 65 to link the splicing and polyadenylation complexes. [provided by RefSeq, Oct 2016 ...