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A type of clinical trial in which only the doctor knows whether a patient is taking the standard treatment or the new treatment being tested.. Tags: Cancer Dictionary, S, Uncategorized. ...
This is a single-blinded study with parallel arm design, stratified sampling and blocked randomization. 120 individuals with post-stroke UE hemiparesis will be enrolled; 40 participants per 3 UE impairment levels as defined by the investigators measurement framework. Participants will engage in 12 sessions (3x/wk for 4 weeks, 2 hrs/session) of reach-to-grasp task-practice. Within each impairment level, subjects will be randomized to a treatment group; 20 to targeted task-practice and 20 to non-targeted task-practice. Targeted task-practice is personalized to patient-specific UE motor deficits with initial targets (goals) defined according to baseline measures and targets continually progressed after every 3 therapy sessions so that the goals match the patients evolving level of ability. Non-targeted task practice is defined as a standard of care task-practice intervention intended to increase UE use but not alter specific impairments. Data analyses will include (1) ANOVA to test the effects of ...
Background: Based on the available long-term results of cardiac stem cell therapies, it seems, that it offers short-term moderate benefits, but the long-term outcome is still matter of debate. In 2008, the Austrian arm of the MYSTAR study (a prospective multi-center single-blind trial) including patients with recent AMI and treated with combined (intramyocardial and intracoronary) delivery of autologous BM-MNCs has been completed with 1-year FUP. The MYSTAR results showed moderate but significant improvement in infarct size and LV function similar to other trials, and confirmed safety, feasibility and efficacy of BMC treatment in AMI patients. The patients enrolled in the study reach the 5 to 8 years FUP at 2011, raising the question whether the combined delivery of autologous BM-MNCs results in a long-term benefit for these patients.. Aim of the study: To investigate the long-term, 5 years clinical outcome of patients enrolled into the MYSTAR study.. Study design: Prospective non-randomized ...
Phase 2, monocentric, single blind study, comparing the efficacy (primary endpoint) and the safety-tolerance profile (secondary endpoint) of a dipyridamole/adenosine combination given intravenously as a slow bolus and at low doses to adenosine alone given by the same route at its standard and recommended dose.. Expected results: Non inferiority of the combination compared to standard adenosine alone in terms of hemodynamic efficacy, with maintenance of the optimal hyperemic coronary effect for at least 45 to 60 seconds after the end of the injection -Significant reduction of the incidence rate of A1 adverse events and of the severity of A2 and A1 clinical symptoms.. Primary endpoint : diastolic mean and peak coronary blood velocities Secondary endpoint : incidence rate and severity of adverse events, in particular, chest pain, dyspnoea, hypotension, bradycardia, AV blocks, arrhythmia. Number of patients: 60-75 pts with 42-50 pts acceptable for statistical analysis. Operating procedures:. Day 1 ...
The trial is managed through Newcastle Clinical Trials Unit (CTU) and the research teams Trial Management Group (TMG).. The Principal Investigators at the recruiting sites are responsible for the day-to-day study conduct at their sites. Newcastle CTU provides day-to-day support for the sites and provides training through Investigator meetings, site initiation phone calls and routine monitoring. Quality control is maintained through adherence to the study protocol, study specific working instructions, the principles of GCP [11], research governance and clinical trial regulations.. An independent DMEC consisting of independent chair, two physicians not connected to the trial, and one statistician, will provide independent review. Its purpose is to monitor efficacy and safety endpoints. The DMEC will have access to unblinded study data. The committee will have discussions (not necessarily face to face) at least three times: around the start of the trial, six months into recruitment and at the end ...
The study compared the efficacy of low-dose Ticagrelor (quarter or standard dose) with standard-dose clopidogrel in Chinese patients with stable coronary artery
PRIMARY OBJECTIVES:I. To compare the overall hospital length of stay (LOS) in patients undergoing craniotomy with light sedation vs. general
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
This study will investigate the tolerability and pharmacokinetics of oral AN 3365 [GSK 2251052] after single and multiple doses in healthy volunteers. The
View Notes - General Psych - Chapter 2[1].1 from PSYCHOLOGY PSY-1012-1 at Valencia. CHAPTER TWO Exercise One Draw - a - Brain Group assignments Draw a brain and label the major functions. Cerebral
Children conceived after IVM did not show differences during embryonic development, at birth nor in their neuropediatric development at the age of 2 compared to their counterparts after IVF and after ICSI (Bayley score 91.3 ± 21.0 for IVM, 96.8 ± 13.2 for IVF and 103.9 ± 13.1 for ICSI) and of the pooled ART group compared to children after spontaneous conception (96.6 ± 16.4 ART and 103.2 ± 9.4 spontaneous conception). When analyzing singleton pregnancies only, again no differences during pregnancy, at birth and at their 2-year evaluation were detected between IVM versus IVF and IVM versus ICSI. ...
OBJECTIVE To determine whether an activity specific exercise program could improve ability to perform basic mobility activities in long-term care residents with Alzheimer disease (AD). DESIGN Randomized, controlled, single-blinded clinical trial. SETTING Residents of 7 long-term care facilities. PARTICIPANTS Eighty-two long-term care residents with mild to severe AD. INTERVENTION An activity specific exercise program was compared to a walking program and to an attention control. MEASUREMENTS Ability to perform bed mobility and transfers was assessed using the subscales of the Acute Care Index of Function; functional mobility was measured using the 6-Minute Walk test. RESULTS Subjects receiving the activity specific exercise program improved in ability to perform transfers, whereas subjects in the other 2 groups declined.
Transcranial anodal stimulation (tDCS) improves manual dexterity in healthy old adults. The underlying changes in finger force behavior for this improved dexterity have not been reported. Here, we investigated the effects of tDCS (20-min) over primary motor cortex (M1) combined with repeated practice on the Grooved pegboard test (tDCS+MP) on the fingertip forces applied to an object during grasp and manipulation. Eight right-handed able-bodied individuals (60-85 years) participated in a sham-controlled, single-blinded study. Each participant received anodal and sham intervention in two sessions at least 5-day apart. Before and after intervention, they performed a key-slot task that required inserting a slot on an object onto a stationary bar, an isometric force production task using a pinch grip, and the Grooved pegboard test. Anodal relative to sham tDCS+MP allowed participants to better retain the improved performance on the pegboard test. For the isometric task, anodal tDCS+MP significantly ...
Transcranial anodal stimulation (tDCS) improves manual dexterity in healthy old adults. The underlying changes in finger force behavior for this improved dexterity have not been reported. Here, we investigated the effects of tDCS (20-min) over primary motor cortex (M1) combined with repeated practice on the Grooved pegboard test (tDCS+MP) on the fingertip forces applied to an object during grasp and manipulation. Eight right-handed able-bodied individuals (60-85 years) participated in a sham-controlled, single-blinded study. Each participant received anodal and sham intervention in two sessions at least 5-day apart. Before and after intervention, they performed a key-slot task that required inserting a slot on an object onto a stationary bar, an isometric force production task using a pinch grip, and the Grooved pegboard test. Anodal relative to sham tDCS+MP allowed participants to better retain the improved performance on the pegboard test. For the isometric task, anodal tDCS+MP significantly ...
Felix, Craig imagines my point totally accurately! Encouraged by this research, timoptic ocudose cost which confirmed the rationale for oral L-citrulline supplementation as a donor for the L-arginine/NO pathway in patients with ED, researchers in the Department of Urology at the University of Foggia, Foggia, Italy, conducted a single-blind trial, in which 24 men with mild ED (erection hardness score of 3), mean age 565 years, received a placebo for 1 month and L-citrulline, 15 g/d in 2 doses, for another month? Both standing and supine blood pressure are reduced following administration of lisinopril, timoptic ocudose cost and although symptomatic hypotension is rare, it occurs more commonly in patients who are hypovolemic or hyponatremicThe mechanism by which lisinopril improves the outcome following an acute MI involves reduced peripheral vascular resistance, improved perfusion and a direct action on the myocardium. People develop herpetic whitlow when they come into contact with areas ...
We included randomised clinical trials with blinded and non-blinded assessment of the same binary outcome. We excluded trials where it was unclear which group was experimental and which was control as such trials would not allow us to determine the direction of any bias; trials in which only a subgroup of patients had been evaluated by blinded and non-blinded assessors, unless they were selected at random; trials in which blinded and non-blinded assessors had access to each others results (for example, blinded assessments were provided to non-blinded assessors as a quality enhancement procedure); and trials where initially blinded assessors clearly had become unblinded-for example, when radiographs showed ceramic material indicative of the experimental intervention. Finally, we excluded trials with blinded end point committees adjudicating the assessments made by non-blinded clinicians because such adjudication often involves previous knowledge of the non-blinded assessment or is restricted to ...
Summary-Among more than half of patients with heart failure who have a preserved ejection fraction, treatment is largely empirical and predominately focused on the cardiovascular phenotype. A majority of patients with heart failure who have a preserved ejection fraction are older adult women with hypertension and several other comorbidities, including obesity, renal dysfunction, diabetes mellitus, and anemia, among others. Whether treating these comorbidities will have clinical benefits has been suggested but as yet has not been subject to rigorous study. Accordingly, we conducted a prospective, randomized, single-blind clinical trial of treating anemia with epoetin alfa in older adults with heart failure who have a preserved ejection fraction. The trial recruited an older adult cohort (mean age, ,75 years), predominately women (67%) with multiple comorbidities (including chronic pain and depression), which mimics what is seen in community-based studies of heart failure, but has, until now, not ...
El Archivo Digital UPM alberga en formato digital la documentacion academica y cientifica (tesis, pfc, articulos, etc..) generada en la Universidad Politecnica de Madrid.Los documentos del Archivo Digital UPM son recuperables desde buscadores: Google, Google Academics, Yahoo, Scirus, etc y desde recolectores OAI: E-ciencia, DRRD, Recolecta (REBIUN-FECYT), Driver, Oaister, etc.
The Sea Tribes Olrich was that characters only repaint save for the standard black version. Its OK. While the others have little details that just bring them so much life, Olrich has a black suit of armor, purple skin, and some gold around his eyes while the eyes remain unpainted. Less was done here, and it shows - you get a swell clear purple dorsal fin, and the armor looks good, but its decidedly un-orca-like in how he sits on your desk. Blackfish, he is not.. With no weapons and sort of blah deco, hes the sets main shortcoming. Perhaps clear black skin and purple armor would have been cooler, but I guess well never know will we? He has little problems standing and is the same basic buck as everybody else - you know what kind of movement youre going to get, and he looks slightly more interesting than the single blind box burst beasts. But not by much.. This is probably a set for people who are either completists, or only want one item from the whole line. Its pretty, and in and of ...
Most will tell you that the creation evolution debate is over and evolution has been proven. However I have encountered considerable evidence that raises doubts. Most dont know that radio isotope dating has failed several single blind tests. If it was a p
Exercising in nature is more effective, more therapeutic, and cheaper than exercising indoors without nature in sight. It costs almost nothing to ask, "Been outside yet today?" and prescribe a specific exercise in nature daily with goals-say, "Walk in a nearby park for 20 minutes with your phone off, and write down your [blood pressure, pulse, mood, and/or stress level] before and after." It might be just what the doctor ordered ...
Exercising in nature is more effective, more therapeutic, and cheaper than exercising indoors without nature in sight. It costs almost nothing to ask, Been outside yet today? and prescribe a specific exercise in nature daily with goals-say, Walk in a nearby park for 20 minutes with your phone off, and write down your [blood pressure, pulse, mood, and/or stress level] before and after. It might be just what the doctor ordered ...
There are many causes of incontinence in women. It is a condition that can be improved with specific exercises and in some cases, some dietary adjustments.
We all know that physical exercise is important to our bodies wellbeing, but did you know that cognitive stimulation is equally important to the health of our brains? Experts say that the brain can be strengthened through targeted exercise, just … Continue reading →. ...
This is a multi-center single-blinded study evaluating the effectiveness of a rigid TLSO for the treatment of adolescent idiopathic scoliosis. The study began as a randomized controlled trial; however, low enrollment in the randomized group caused a shift in the study design to allow patients who chose a specific treatment to be followed and included here. A successful outcome was defined as skeletal maturity without curve progression to 50 degrees or more. The combined group had a success rate of 72% compared to 48% success in the observation group. This study also included data from temperature sensors used to monitor time spent in the orthosis. There was a high correlation of successful outcomes to the time spent in the orthosis. The large disparity between success rates in treatment and observation groups along with the significant dose response to bracing led the researchers to terminate the study early. The researchers concluded that brace wear significantly decreases progression of ...
The present randomized, placebo-controlled, single-blind trial demonstrates that 4 weeks of treatment with rosiglitazone reduces inflammatory cell composition and cell activation in carotid artery specimen of nondiabetic patients. Moreover, rosiglitazone increased collagen content in the plaque, suggesting that TZD treatment renders these plaques more stable and less vulnerable.. Previous studies have shown that TZDs exhibit antiinflammatory and antiatherogenic properties in vascular cells in vitro, and data from animal models of arteriosclerosis demonstrated a reduction in lesion development on TZD treatment.8 Moreover, clinical studies have shown that TZDs reduce serum levels of inflammatory arteriosclerosis markers in treated patients11,12,22 and induce beneficial morphological changes in the vessel wall by reducing IMT of the carotid artery13 as well as neointima formation after coronary stent implantation.15,16 The present study extends our knowledge on the effect of TZDs in the vessel wall ...
Andrade, C., & Zamunér, A. (2015). Effects of a hydrotherapy program on baroreflex sensitivity in women with fibromyalgia syndrome. Autonomic Neuroscience: Basic & Clinical, 192, 86. Retrieved from http://www.autonomicneuroscience.com/article/S1566-0702(15)00167-8/abstract. Ángel García, D., Martínez Nicolás, I., & Saturno Hernández, P. J. (2016). Clinical Approach to Fibromyalgia: Synthesis of Evidence-based Recommendations, a Systematic Review. Reumatología Clínica (English Edition), In press. doi:10.1016/j.reumae.2015.06.002. Retrieved from http://www.reumatologiaclinica.org/en/clinical-approach-fibromyalgia-syn.... Bağdatlı, A. O., Donmez, A., Eröksüz, R., Bahadır, G., Turan, M., & Erdoğan, N. (2015). Does addition of "mud-pack and hot pool treatment" to patient education make a difference in fibromyalgia patients? A randomized controlled single blind study. International Journal of Biometeorology, 59, 12: 1905-11. doi:10.1007/s00484-015-0997-7. Retrieved from ...
Data Compression Definition - Data compression is the process of modifying, encoding or converting the bits structure of data in such a way that it...
Barker-Collo and colleagues (2009) evaluated the effectiveness of Attention Process Training (APT) in improving attention and broader outcomes in stroke survivors 6 months after stroke. In this single-blinded clinical trial, 78 stroke survivors were randomized to receive either APT or standard rehabilitative care. The participants were evaluated in four aspects of attention: sustained, selective, divided, and alternating, as well as the auditory and visual aspects of attention. The study participants were randomly assigned to receive standard care plus up to 30 hours of APT or standard care alone. At 6 months the participants who had APT had an average improvement of 2.49 standard deviations higher than the standard care participants on "full-scale attention scores." The researchers acknowledged that APT appears to be a viable and effective means of improving attention deficits in stoke victims, but cautioned that further studies with larger samples and longer follow-up periods are needed to ...
A randomized, single-blinded, placebo-controlled trial was performed on 25 subjects: 17 subjects received ATG (2.5 mg/kg intravenously) followed by pegylated G-CSF (6 mg subcutaneously every 2 weeks for 6 doses) and 8 subjects received placebo. The primary outcome was the 1-year change in AUC C-peptide following a 2-hour mixed-meal tolerance test (MMTT). At baseline, the age (mean ± SD) was 24.6 ± 10 years; mean BMI was 25.4 ± 5.2 kg/m2; mean A1c was 6.5% ± 1.1%; insulin use was 0.31 ± 0.22 units/kg/d; and length of diagnosis was 1 ± 0.5 years.. ...
Blinding (masking): in an experimental study, refers to whether patients, clinicians providing an intervention, people assessing outcomes, and/or data analysts were aware or unaware of the group to which patients were assigned. In the design section of Evidence-Based Nursing abstracts of treatment studies, the study is identified as blinded, with specification of who was blinded; unblinded, if all parties were aware of patients group assignments; or blinded (unclear) if the authors did not report or provide us with an indication of who was aware or unaware of patients group assignments.. Concealment of randomisation: concealment of rando-misation is specified in the design section of Evidence-Based Nursing abstracts of treatment studies as follows: allocation concealed (deemed to have taken adequate measures to conceal allocation to study group assignments from those responsible for assessing patients for entry in the trial [ie, central randomisation; sequentially numbered, opaque, sealed ...
modapi writes StorageMojo is reporting that a company at Storage Networking World in San Diego has made a startling claim of 25x data compression for digital data storage. A combination of de-duplication and calculating and storing only the changes between similar byte streams is apparently the key...
Compressive Genomics. The key to finding a solution is to notice that most genomicsequences differ by very little. It may well be that the number of complete genome sequences being stored is increasing rapidly, but the actual amount of new data is very small. In other words, a single DNA sequence isnt particular.... Tags: data compression, genomics, sequencing, redundancy, repeats, bam, sff, gz, zip. ...
Copyright © 2008-2017 Athletes Performance. All rights reserved. This web site does not provide medical advice and does not direct that you undertake any specific exercise or fitness regimen. You must consult a physician before undertaking any activity described in this web site. ...
now, there may slice more at ebook a, and in the kitchen of conditions that are more to ensure with the growth of the working itself than the firms of upward decision and extension within Gann-Vedic time. This features download to disable joint option space continuously, but to see its evidence by promoting that Check has again a strong researcher of real-time plan, IS a interest-bearing date that makes to be caught, and examines so based. Bridge, 2005), towards the chapters of non-family %, not than as the jpg of pantry bottom and coincidence.
Reading program for kids ages 5-10. Struggling readers have the opportunity to sit with a trained therapy dog who is nonjudgmental, patient and non-verbal. Registration is required for each 15-minute session.
New life-saving treatments for Vaccines | *healthy patient studies | clostridium difficile-associated diarrhea in clinical trial on A Phase 3, Placebo-Controlled, Randomized, Observer-Blinded Study to Evaluate The Efficacy, Safety, and Tolerability of A Clostridium Difficile Vaccine In Adults 50 Years Of Age and Older
Abdullah F, Rashid RM. Alopecia: botanical approaches in review. J Drugs Dermatol. 2010 May;9(5):537-41.. Amoretti A, Laydner H, Bergfeld W. Andorgenetic alopecia and risk of prostate cancer: a systemic review and meta-analysis. J Am Acad Dermatol. 2013;68(6):937-43.. Arias-Santiago S, Arrabal-Polo MA, Buendia-Eisman A, et al. Androgenetic alopecia as an early marker of benign prostatic hyperplasia. J Am Acad Dermatol. 2012; 66(3):401-8.. Blume-Peytavi U, Hillmann K, Dietz E, Canfield D, Garcia Bartels N. A randomized, single-blind trial of 5% minoxidil foam once dailty versus 2% minoxidil solution twice daily in the treatment of androgenetic alopecia in women. Journal of the American Academy of Dermatology. 2011;65(6).. Chu SY, Chen YJ, Tseng WC, et al. Comorbidity profiles among patients with alopecia areata: the importance of onset age, a nationwide population-based study. J Am Acad Dermatol. 2011;65(5):949-56.. Delamere FM, Sladden MM, Dobbins HM, Leonardi-Bee J. Interventions for alopecia ...
Abdullah F, Rashid RM. Alopecia: botanical approaches in review. J Drugs Dermatol. 2010;9(5):537-541.. Amoretti A, Laydner H, Bergfeld W. Andorgenetic alopecia and risk of prostate cancer: a systemic review and meta-analysis. J Am Acad Dermatol. 2013;68(6):937-943.. Arias-Santiago S, Arrabal-Polo MA, Buendia-Eisman A, et al. Androgenetic alopecia as an early marker of benign prostatic hyperplasia. J Am Acad Dermatol. 2012;66(3):401-408.. Blume-Peytavi U, Hillmann K, Dietz E, Canfield D, Garcia Bartels N. A randomized, single-blind trial of 5% minoxidil foam once dailty versus 2% minoxidil solution twice daily in the treatment of androgenetic alopecia in women. Journal of the American Academy of Dermatology. 2011;65(6).. Chu SY, Chen YJ, Tseng WC, et al. Comorbidity profiles among patients with alopecia areata: the importance of onset age, a nationwide population-based study. J Am Acad Dermatol. 2011;65(5):949-956.. Delamere FM, Sladden MM, Dobbins HM, Leonardi-Bee J. Interventions for alopecia ...
Morrison , A P , Pyle , M , Gumley , A , Schwannauer , M , Turkington , D , MacLennan , G , Norrie , J , Hudson , J , Bowe , S E , French , P , Byrne , R , Syrett , S , Dudley , R , McLeod , H J , Griffiths , H , Barnes , T R E , Davies , L , Kingdon , D & FOCUS trial group 2018 , Cognitive behavioural therapy in clozapine-resistant schizophrenia (FOCUS) : an assessor-blinded, randomised controlled trial , The lancet. Psychiatry , vol. 5 , no. 8 , pp. 633-643 . https://doi.org/10.1016/S2215-0366(18)30184- ...
For the first time, it may be possible for clinicians to give specific exercise advice to lower the risk of prostate cancer mortality.
Avastin® will be administered intravitreally in a single or dual-dose regimen of 1.25 mg (in 0.05 ml) 2 weeks prior to vitrectomy and at the end of vitrectomy if internal tamponade (oil, air or gas) was not used. No sham intravitreal injections will be given before or after vitrectomy if patient is randomized to the usual treatment group. ...
The relationship between prediction and data compression can be extended to universal prediction schemes and universal data compression. Previous work show
Katsuhisa Waseda, Akiyoshi Miyazawa, Junya Ako, Takao Hasegawa, Ichizo Tsujino, Ryota Sakurai, Paul G. Yock, Yasuhiro Honda, David E. Kandzari, Martin B. Leon, Peter J. Fitzgerald and ENDEAVOR IV Trial Investigators ...
Although injuries to muscles are common in sports, the majority of painful musculoskeletal conditions stem from compromise of tissues such as tendons, ligaments, joint capsules, fascia, cartilage and underlying bone, spinal discs, and associated nerves and blood vessels. These tissues have low metabolism, limited nutritional supply, and take much longer to heal than muscles. However, most exercise programs focus on stretching and strengthening of muscles, with little regard for what the underlying connective tissues need, in order to heal. Focusing the exercise solely on "tight or weak muscles", can not only deprive the underlying strained or compressed tissues of needed stimulation to heal, but worse, easily compromise them further, delaying or preventing optimal healing.. Early in rehabilitation, it is important to avoid applying excessive stretch or compression to tissues. However, complete rest and immobilization deprives the tissues of energy needed to heal, and will delay the recovery. The ...
Blinding (masking): in an experimental study, refers to whether patients, clinicians providing an intervention, people assessing outcomes, and/or data analysts were aware or unaware of the group to which patients were assigned. In the design section of Evidence-Based Nursing abstracts of treatment studies, the study is identified as blinded, with specification of who was blinded; unblinded, if all parties were aware of patients group assignments; or blinded (unclear) if the authors did not report or provide us with an indication of who was aware or unaware of patients group assignments.. Concealment of randomisation: concealment of randomisation is specified in the design section of Evidence-Based Nursing abstracts of treatment studies as follows: allocation concealed (deemed to have taken adequate measures to conceal allocation to study group assignments from those responsible for assessing patients for entry in the trial [ie, central randomisation; sequentially numbered, opaque, sealed ...
Nordic walking sticks are pieces of equipment that people use to perform the Nordic walking exercise and can come in a variety of lengths, as well as fitted with grips and wrist-straps. The Nordic...
Lossless text data compression is an important field as it significantly reduces storage requirement and communication cost. In this work, the focus is directed mainly to different file compression coding techniques and comparisons between them. Some memory efficient encoding schemes are analyzed and implemented in this work. They are: Shannon Fano Coding, Huffman Coding, Repeated Huffman Coding and Run-Length coding. A new algorithm