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This study aimed to evaluate the chemical stability of sincalide at 2 common storage conditions-room temperature and refrigeration-in an attempt to simulate the conditions faced during centralized reconstitution and subsequent distribution to regional clinical facilities. Sincalide is a peptide hormone product administered parenterally as an aid for diagnostic imaging of hepatobiliary conditions. With an estimated postreconstitution shelf-life of 8 h (updated by the manufacturer in 2014 with limited supporting data) and frequent shortages due to an intermittent supply, there is both clinical and economic value in the experimental determination of the true chemical stability of this agent. Methods: Sincalide was reconstituted and stored at both temperatures (n = 4 each), and samples were collected at predetermined time points. A validated high-performance liquid chromatography analytic method was used for quantification of the active ingredient in these samples. Results: Little to no chemical ...
TY - JOUR. T1 - Effects of 1-oleoyl-2-acetyl glycerol are distinct from those of phorbol ester in rat pancreatic acini. AU - Scott Brockenbrough, J.. AU - Korc, Murray. PY - 1987/4/20. Y1 - 1987/4/20. N2 - 1-oleoyl-2-acetyl glycerol (OAG), a potent activator of protein kinase C, inhibited the binding of 125I-labelled epidermal growth factor (EGF) in isolated rat pancreatic acini. Unlike cholecystokinin-octapeptide (CCK8) and the C-kinase activator 12-0-tetradecanoyl phorbol-13-acetate (TPA), two inhibitors of 125I-EGF endocytosis in the pancreas, OAG had no effect on the distribution of bound ligand between the cell surface and intracellular compartments. Unlike TPA, OAG failed to potentiate the inhibitory effects of the calcium ionophore A23187 on 125I-EGF cell-associated radioactivity and had no effect on either basal or carbachol-stimulated amylase release in acini. These data suggest that the actions of the synthetic diacylglycerol OAG are not fully equivalent with the action of other known ...
Y , StdInChIKey = , bioavailability = 100% , protein_bound = , metabolism = proteaze plazme , elimination_half-life = 13 minuta , excretion = N/A , pregnancy_AU = , pregnancy_US = , pregnancy_category= , legal_AU = , legal_CA = , legal_UK = , legal_US = , legal_status = , routes_of_administration = IV }} CCK-4 (holecistokininski tetrapeptid, Trp-Met-Asp-Phe-NH2; ili PTK7) je peptidni fragment izveden iz većeg peptidnog hormona holecistokinina. Za razliku od holecistokina koji ima niz uloga u gastrointestinalnom sistemu kao i u centralnom nervnom sistemu, CCK-4 deluje prvenstveno u mozgu kao stimulator anksioznosti. On pokazuje slabe GI efekte, za razliku od CCK-8 ili polipeptida pune dužine, CCK-58. CCK-4 proizvodi jake simptome anksioznosti u malim dozama, kao što je 50 μg,[1] i često se koristi u naučnim istraživanjima za indukovanje paničnih napada s ciljem testiranja novih anksiolitika.[2][3][4][5] Pošto je on peptid, CCK-4 mora biti administriran putem injekcije. U telu se brzo ...
ProSpecs Peptide Hormones include: ACTH, Antide, Argipressin, Atosiban, Buserelin, Cetrorelix, DDAVP, Deslorelin, Elcatonin, Exenatide, Exendin-4, Ganirelix, GHRL, GHRP-2, GHRP-6, Goserelin, Hexarelin, Histrelin, Lanreotide, Lypressin, MT-II, NAF, PMSG, Secretin, Sincalide, Pramlintide, Somatostatin, Terlipressin, Triptorelin Acetate, Thymopentin, Thymosin- α1, Thymosin β4, Vasopressin
The accompanying paper (Bignon et al., 1999) on SR146131 describes the compounds effects as a potent and selective agonist at both human and rodent CCK1 receptors in vitro. The present paper evaluated the drugs effects in vivo, and shows clearly that SR146131 can mimic, in a variety of test systems and in several species, a wide range of the effects of sulfated cholecystokinin octapeptide (CCK8S), which have previously been attributed to the stimulation of CCK1 receptors but not those related to the stimulation of CCK2 receptors.. SR146131 inhibited gastric emptying in mice, and also decreased gallbladder volume in this species after administration of low oral doses. SR146131 also reduced food intake in two rodent and one primate species. The compound reduced food intake in fasted rats, and in nonfasted rats in which food intake had been highly stimulated by the administration of NPY(1-36). Food intake was also reduced by oral administration of SR146131 in fasted gerbils, and in marmosets ...
As nouns the difference between octapeptide and octreotide is that octapeptide is an oligopeptide having eight amino acids while octreotide is...
Cholecystokinin and related peptides are involved in the control of intestinal motility and cholecystokinin receptor ligands might represent new pharmacological tools for the treatment of symptoms associated with functional bowel disorders. However, the respective roles played by cholecystokinin receptor subtypes and the mechanisms underlying these regulatory actions remain undetermined. This study was designed to examine the influence of cholecystokinin receptor subtypes on the motor activity of guinea-pig distal colon. The effects of drugs acting on CCK1 and CCK2 receptors were assessed in vitro on the contractile activity of longitudinal smooth muscle, both under basal conditions and in the presence of transmural electrical stimulation or KCl-induced contractions. The application of cholecystokinin octapeptide sulphate (cholecystokinin-8S) to colonic preparations induced concentration-dependent contractions which were prevented by devazepide (CCK1 receptor antagonist), enhanced by GV150013 ...
TY - JOUR. T1 - Multiple kinases phosphorylate the pancreatic cholecystokinin receptor in an agonist-dependent manner. AU - Gates, L. K.. AU - Ulrich, C. D.. AU - Miller, L. J.. PY - 1993/1/1. Y1 - 1993/1/1. N2 - The cholecystokinin (CCK) receptor on the rat pancreatic acinar cell is a guanine nucleotide-binding protein (G protein)-coupled receptor, which was recently demonstrated to be phosphorylated in response to agonist stimulation (Klueppelberg et al., J. Biol. Chem. 266: 17744-17746, 1991). In this work, we establish that this receptor is phosphorylated in response to a variety of homologous and heterologous secretagogues and that these phosphorylation events represent action by more than one protein kinase. One subgroup of kinases includes one or more isotype of protein kinase C (PKC), and is capable of playing a role in homologous and heterologous desensitization. A second subgroup of kinases that acts on the CCK receptor was defined by its resistance to 10 μM staurosporine, which was ...
TY - JOUR. T1 - A role for cholecystokinin-stimulated protein tyrosine phosphorylation in regulated secretion by the pancreatic acinar cell. AU - Lutz, M. P.. AU - Sutor, S. L.. AU - Abraham, R. T.. AU - Miller, L. J.. PY - 1993/1/1. Y1 - 1993/1/1. N2 - Cholecystokinin (CCK) is a gastrointestinal hormone that acts through a G protein-coupled receptor to stimulate pancreatic enzyme secretion. In this work, we demonstrate that CCK stimulation of dispersed pancreatic acini results in increased tyrosine phosphorylation of several cellular proteins. This is mediated via a calcium-dependent pathway, also activated by a phenethyl ester analogue of CCK and calcium ionophores, and by a protein kinase C-dependent cascade, also activated by the phorbol ester 12-O- tetradecanoylphorbol-13-acetate. All demonstrable stimulated tyrosine phosphorylation events were inhibited by genistein, with different subsets of proteins affected by staurosporine and H-7. The importance of tyrosine phosphorylation events in ...
The cat caudate nucleus has been reported to possess a rich and fairly even distribution of nerve endings, containing both dopamine- and cholecystokinin-like peptides. In this study, the effect of cholecystokinin-octapeptide (CCK-8) on basal and electrically evoked tritium outflow from slices of cat caudate nucleus previously labeled with [3H]dopamine was examined. Evoked tritium outflow from slices of cat caudate nucleus was Ca2+ dependent and abolished by tetrodotoxin, suggesting that it reflects action potential-induced [3H]dopamine release. In the presence of bovine serum albumin and bacitracin, the sulfated but not the unsulfated form of CCK-8 inhibited both basal and electrically evoked tritium outflow from slices of cat caudate nucleus at very low concentrations. CCK-8 sulfate was efficient in causing this effect in concentrations down to 10(-14) M, and the maximum effect was obtained with 10(-11) M. In contrast, without bovine serum albumin and bacitracin, no inhibitory effect of CCK-8 ...
The IUPHAR/BPS Guide to Pharmacology. desulfated cholecystokinin-8 ligand page. Quantitative data and detailed annnotation of the targets of licensed and experimental drugs.
CCKAR山羊多克隆抗体(ab77269)可与大鼠, 人样本反应并经WB, ELISA, IHC, ICC/IF实验严格验证,Abcam CCKAR抗体被1篇文献引用。所有产品均提供质保服务,中国75%以上现货。
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We have previously demonstrated [M. Campos-Toimil, T. Bagrij, J.M. Edwardson, P. Thomas, Two modes of secretion in pancreatic acinar cells: involvement of phosphatidylinositol 3-kinase and regulation by capacitative Ca2+ entry, Curr. Biol. 12 (2002) 211-215] that in rat pancreatic acinar cells, Gd3+-sensitive Ca2+ entry is instrumental in governing which second messenger pathways control secretory activity. However, in those studies, we were unable to demonstrate a significant increase in cytoplasmic [Ca2+] during agonist application as a result of this entry pathway. In the present study, we combined pharmacology with ratiometric imaging of fura-2 fluorescence to resolve this issue. We found that 2 μM Gd3+ significantly inhibits store-mediated Ca2+ entry. Furthermore, both the protonophore, CCCP (5 μM) and the mitochondrial Ca2+-uptake blocker, RU360 (10 μM), led to an enhancement of the plateau phase of the biphasic Ca2+ response induced by acetylcholine (1 μM). This enhancement was ...
Kiyama, H.; Shiosaka, S.; Kubota, Y.; Cho, H.J.; Takagi, H.; Tateishi, K.; Hashimura, E.; Hamaoka, T.; Tohyama, M., 1983: Ontogeny of cholecystokinin-8 containing neuron system of the rat: an immunohistochemical analysis--II. Lower brain stem
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TY - JOUR. T1 - Isolated pancreatic acini from suckling and weanling rats. T2 - Changes in amino acid incorporation and carbachol-stimulated amylase secretion with age. AU - Pollack, Paul F.. AU - Verbridge, Jill. AU - Thornburg, William. AU - Koldovsky, Otakar. AU - Korc, Murray. PY - 1986/1/1. Y1 - 1986/1/1. N2 - To characterize the changes in pancreatic function during postnatal development, isolated pancreatic acini were prepared from rats aged 8-9, 12-14 and 20 days and from adult rats. Isolated acini maintained a normal microscopic appearance and viability as judged by exclusion of trypan blue and linear incorporation of tritiated leucine into total protein. The rate of incorporation in 8-day-old acini was 20% of that observed in adult rats. Significant dose-dependent increases in amylase release in response to carbachol were observed in all age groups; stimulated amylase secretion was significantly less in the 8- to 9- and 12- to 14-day-old animals than in the 20-day-old and adult rats. ...
The gastric enterochromaffin-like (ECL) cell se cretes histamine in response to secretagogues (gastrin, acetylcholine) by calcium signaling-dependent exocytosis of intracellular vacuoles containing the hormone. ECL cells were isolated from rat fundic gastric mucosa by elutriation and density-gradient centrifugation. Currents across the plasma membrane were measured using whole cell patch-clamp methods. These cells had a low conductance of 0.5 nS and resting potential of -50 mV Depolarization activated a K+ current that was blocked by Ba2+. Steady-state current in absence of K+ was due to Cl- because of the magnitude of the reversal potential and the effects of Cl- removal. Stimulation of secretion by gastrin, cholecystokinin octapeptide (CCK-8), and the phorbol ester 12-O-tetradecanoylphorbol 13-acetate activated the Cl- conductance with a time course similar to that of histamine release. Therefore the ECL cell maintains a high resting potential, largely due to K+ currents, and stimulation of ...
Cell surface proteins that bind cholecystokinin (CCK) with high affinity and trigger intracellular changes influencing the behavior of cells. Cholecystokinin receptors are activated by GASTRIN as well as by CCK-4; CCK-8; and CCK-33. Activation of these receptors evokes secretion of AMYLASE by pancreatic acinar cells, acid and PEPSIN by stomach mucosal cells, and contraction of the PYLORUS and GALLBLADDER. The role of the widespread CCK receptors in the central nervous system is not well understood. . ...
In the present study, we characterized the metabolic profile of the recently described lean Cck1r−/− rat on a Fischer 344 background. With our unique animal model, we hypothesized that the lean Cck1r−/− rats would show increased meal size and energy expenditure relative to their Fischer 344 wild-type counterparts. Cck1r−/− rats consumed larger meals during the dark cycle and smaller meals during the light cycle. These effects were accompanied by increased total spontaneous activity and energy expenditure during the dark cycle, as well as an apparent shift toward increased fat utilization as demonstrated by the reduction in RQ during the light cycle. On the basis of the findings in the OLETF rats (3), we predicted that both Cck1r+/+ and Cck1r−/− rats would show increased weight gain during chronic exposure to a highly palatable, HFD. Indeed, both Cck1r+/+ and Cck1r−/− rats were prone to DIO when maintained on a HFD, which was associated with increased serum leptin levels. We ...
Cholecystokinin tetrapeptide (CCK-4, also PTK7) is a peptide fragment derived from the larger peptide hormone cholecystokinin. CCK-4 acts primarily in the brain as an anxiogenic, although it does retain some GI effects, but not as much as CCK-8 or the full length polypeptide CCK-58.
L-365260 is a selective cholecystokinin receptor 2 (CCK2) antagonist (IC50 values are 2 and 280 nM at CCK2 and CCK1 receptors respectively).
Complete information for CCKBR gene (Protein Coding), Cholecystokinin B Receptor, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
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tuftsinyltuftsin: octapeptide consisting of 2 moles of tufsin; better than tuftsin in prolonging life of syngeneic mice injected with L1210 leukemia cells
TY - JOUR. T1 - Cholecystokinin secretagogue-induced gastroprotection. T2 - Role of nitric oxide and blood flow. AU - West, Sonlee D.. AU - Helmer, Kenneth S.. AU - Chang, Lily K.. AU - Cui, Yan. AU - Greeley, George H.. AU - Mercer, David W.. PY - 2003/3/1. Y1 - 2003/3/1. N2 - This study was done to examine the role of CCK in gastric mucosal defense and to assess the gastroprotective roles of nitric oxide and blood flow. In rats, the CCK secretagogues oleate and soybean trypsin inhibitor augmented gastric mucosal blood flow and prevented gastric injury from luminal irritants. Type A CCK receptor blockade negated CCK secretagogue-induced gastroprotection and exacerbated gastric injury from bile and ethanol but did not block adaptive cytoprotection. CCK secretagogue-induced gastroprotection and hyperemia were negated by nonselective nitric oxide synthase (NOS) inhibition (nG-nitro-L-arginine methyl ester) but not by selective inducible NOS inhibition (aminoguanidine). Gastric mucosal ...
The mechanisms regulating the proliferation and differentiation processes that give rise to and maintain the gastric epithelium have not yet been completely elucidated.. In the present studies, in vitro models were established and the influence of growth factors and extracellular matrix proteins on these processes were investigated. Pentagastrin and hydrocortisone were found to accelerate the development of H,KTPase-positive parietal cells and other epithelial cells from undifferentiated gastric epithelial cells of foetal rats. These undifferentiated cells and also presumably immature epithelial cells in the progenitor zone of adult gastric glands were shown to express cholecystokinin-2 (CCK2) receptors and are therefore targets for the trophic action of gastrin.. H,K-ATPase-positive parietal cells in the progenitor zone of adult glands were also found to express CCK2 receptors, indicating that gastrin may stimulate maturation of the parietal cell lineage even during adult life. Parietal cells ...
Agonist-specific cytosolic Ca2+ oscillation patterns can be observed in individual cells and these have been explained by the co-existence of separate oscillatory mechanisms. In pancreatic acinar cells activation of muscarinic receptors typically evokes sinusoidal oscillations whereas stimulation of cholecystokinin (CCK) receptors evokes transient oscillations consisting of Ca2+ waves with long intervals between them. We have monitored changes in the cytosolic Ca2+ concentration ([Ca2+]i) by measuring Ca2(+)-activated Cl- currents in single internally perfused mouse pancreatic acinar cells. With minimal intracellular Ca2+ buffering we found that low concentrations of both ACh (50 nM) and CCK (10 pM) evoked repetitive short-lasting Ca2+ spikes of the same duration and frequency, but the probability of a spike being followed by a longer and larger Ca2+ wave was low for ACh and high for CCK. The probability that the receptor-evoked shortlasting Ca2+ spikes would initiate more substantial Ca2+ waves was
A combination of autoradiographical techniques and computerized image analysis has been used to study the distribution and density of cholecystokinin receptors in the paraventricular and supraoptic nuclei of animals in which the magnocellular-posterior pituitary axis is activated, namely, in salt-lo …
To identify the molecular components of the vasoactive intestinal peptide (VIP) binding sites in the liver, 125I-labelled VIP was covalently linked to liver membranes by using the cleavable cross-linker dithiobis(succinimidylpropionate). Purified rat liver plasma membranes were incubated with 125I-VIP, washed and treated with 1 mM-cross-linker. Polyacrylamide-gel electrophoresis of membrane proteins followed by autoradiography revealed a major 125I-VIP-protein complex of Mr 51 000. A minor Mr 89 000 complex was also observed. An identical pattern of protein labelling was obtained using crude membranes from rat liver. Labelling of the Mr 51 000 and 89 000 species was specific in that it could be abolished by native VIP, but was unaffected by 1 microM-glucagon and cholecystokinin octapeptide. Densitometric scanning of autoradiographs indicated that the labelling of the two species was abolished by similar low VIP concentrations (0.1-100 nM). It was also reduced by two VIP agonists, peptide ...
Receptor ligands, identified as antagonists, based on the absence of stimulation of signaling, can rarely stimulate receptor internalization. d-Tyr-Gly-[(Nle(28,31),d-Trp(30))CCK-26-32]-2-phenylethyl ester (d-Trp-OPE) is such a ligand that binds to the cholecystokinin (CCK) receptor and stimulates internalization. Here, the molecular basis of this trafficking event is explored, with the assumption that ligand binding initiates conformational change, exposing an epitope to direct endocytosis. Ligand-stimulated internalization was studied morphologically using fluorescent CCK and d-Trp-OPE. d-Trp-OPE occupation of Chinese hamster ovary cell receptors stimulated internalization into the same region as CCK. Arrestin-biased action was ruled out using morphological translocation of fluorescent arrestin 2 and arrestin 3, moving to the membrane in response to CCK, but not d-Trp-OPE. Possible roles of the carboxyl terminus were studied using truncated receptor constructs, eliminating the proline-rich distal tail
Definition of cholecystokinin in the Financial Dictionary - by Free online English dictionary and encyclopedia. What is cholecystokinin? Meaning of cholecystokinin as a finance term. What does cholecystokinin mean in finance?
Cholecystokinin A Receptor: A subtype of cholecystokinin receptor found primarily in the PANCREAS; STOMACH; INTESTINE; and GALLBLADDER. It plays a role in regulating digestive functions such as gallbladder contraction, pancreatic enzyme secretion and absorption in the GASTROINTESTINAL TRACT.
Bombesin pseudo-peptide analogues containing a hydroxamide function on the C-terminal part of the molecule, e.g. H-D-Phe-Gln-Trp-Ala-Val-Gly-His-Leu-NHOBzl 1 and H-D-Phe-Gln-Trp-Ala-Val-Gly-His-Leu-NHOH 2 were synthesized. These compounds were tested for their ability to recognize the bombesin receptor on rat pancreatic acini and on 3T3 cells, to stimulate (i) amylase secretion from rat pancreatic ...
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Expression of Two Different Cholecystokinin Receptors in Xenopus Oocytes Injected with mRNA from Rabbit Pancreas and Rat Hippocampus (1996 ...
Caffeine inhibits a low affinity but not a high affinity mechanism for cholecystokinin-evoked Ca2+ signalling and amylase release from guinea pig pancreatic acini.Naunyn ...
TY - JOUR. T1 - Xanthine oxidase-mediated intracellular oxidative stress in response to cerulein in rat pancreatic acinar cells. AU - Suzuki, Hidekazu. AU - Suematsu, Makoto. AU - Miura, Soichiro. AU - Asako, Hiroshi. AU - Kurose, Iwao. AU - Ishii, Hiromasa. AU - Houzawa, Shigenari. AU - Tsuchiya, Masaharu. PY - 1993/7. Y1 - 1993/7. N2 - Intralobular oxygen radical formation was examined in cerulein-stimulated rat pancreatic acinar cells by digital imaging microscopic fluorography using a hy-droperoxide-sensitive fluorescent probe, dichlorofluores-cin (DCFH) diacetate. The isolated pancreatic acinar cells loaded with DCFH diacetate were microscopically observed, and the dichlorofluorescein (DCF) fluorescence yielded by DCFH oxidation via hydroperoxides was digitally processed. Within the initial 20 min after the application of cerulein (10 μM), intracellular oxidative stress was observed as indicated by the increase in DCF fluorescence intensity and reached its maximum at 60 min. DCF ...
TY - JOUR. T1 - Endogenous cholecystokinin is not a major regulator of food intake in the chicken. AU - Choi, Y. H.. AU - Furuse, M.. AU - Satoh, S.. AU - Okumura, J.. PY - 1994/1/1. Y1 - 1994/1/1. N2 - This study investigated whether or not endogenous cholecystokinin exerts satiety effects in chickens. After several doses (0, 1, 2 and 4 μg·kg body weight-1) of intravenous injection of caerulein, the bile flow was increased in a dose-dependent fashion. However, the pharmacological level of caerulein failed to suppress the food intake of chickens. Two potent stimulators of endogenous cholecystokinin, i.e., soybean trypsin inhibitor and phenylalanine were administered to chickens before feeding and food intake was determined over 2 h. The soybean trypsin inhibitor and phenylalanine did not alter food intake. Devazepide, a cholecystokinin-A receptor antagonist, significantly decreased amylase release from the dispersed chicken pancreatic acini stimulated by caerulein. However, devazepide did not ...
TY - JOUR. T1 - Transporter-mediated bile acid uptake causes Ca2+-dependent cell death in rat pancreatic acinar cells. AU - Kim, Joo Young. AU - Kim, Kyung Hwan. AU - Lee, Jin Ah. AU - Namkung, Wan. AU - Sun, An Qiang. AU - Ananthanarayanan, Meena. AU - Suchy, Frederick J.. AU - Shin, Dong Min. AU - Muallem, Shmuel. AU - Lee, Min Goo. PY - 2002. Y1 - 2002. N2 - Background & Aims: The mechanism by which cholelithiasis increases the risk of acute pancreatitis remains obscure. Because bile acids can enter the pancreas either by luminal diffusion or by interstitial leakage during gallstone impaction and pancreatitis is associated with impaired Ca2+ signaling, we examined the effect of bile acids on pancreatic acinar cell signaling and the associated intracellular events. Methods: Rat pancreatic acinar cells were isolated. by collagenase digestion and the effects of bile acids on [Ca2+]i signaling, cell survival, inflammatory signals, and the molecular and functional expressions of bile uptake ...
Gastrin is a peptide hormone that stimulates secretion of gastric acid by the parietal cells of the stomach. Gastrin binds to a G-protein coupled receptor encoded by the CCKBR gene that also binds cholecystokinin (CCK), a brain regulatory peptide. The receptor is therefore known as the gastrin/cholecystokinin type B receptor. It is also known as cholecystokinin B receptor, cholecystokinin-2 receptor, CCK-B, CCKB-R, CCKRB, CCK2R, and GASR. The gastrin/cholecystokinin receptor is expressed mostly in central nervous system and the gastrointestinal tract. A misspliced transcript variant of the CCKBR gene that includes an intron has been associated with colorectal and pancreatic tumors.. ...
CCK receptors significantly influence neurotransmission in the brain, regulating anxiety, feeding, and locomotion. CCK-B expression may correlate parallel to anxiety and depression phenotypes in humans. CCK-B receptors possess a complex regulation of dopamine activity in the brain. CCK-B activation appears to possess a general inhibitory action on dopamine activity in the brain, opposing the dopamine-enhancing effects of CCK-A. However, the effects of CCK-B on dopamine activity vary depending on location.[11] CCK-B antagonism enhances dopamine release in rat striatum.[12] Activation enhances GABA release in rat anterior nucleus accumbens.[13] CCK-B receptors modulate dopamine release, and influence the development of tolerance to opioids.[14] CCK-B activation decreases amphetamine-induced DA release, and contributes to individual variability in response to amphetamine.[15] In rats, CCK-B antagonism prevents the stress-induced reactivation of cocaine-induced conditioned place preference, and ...
The peptide hormone cholecistokinin (CCK) plays a key role in the central and peripheral nervous system. It is known to be involved in the digestive physiology and in the regulation of food intake. Moreover, the CCK expression has also been detected in the retina of different vertebrates, including fish, although its biological activity in this tissue remains to be elucidated. In literature no data are yet available about the CCK-immunoreactivity in the zebrafish retina during development. Therefore, the aim of the study was to investigate the distribution of sulfated cholecystokinin octapeptide (CCK8-S) as a well preserved form during evolution in the zebrafish retina from 3days post hatching (dph) until adult stage, using immunohistochemistry in order to elucidate the potential role of this protein in the development and maintenance of normal retinal homeostasis. The cellular distribution of CCK in the retina was similar from 3 dph to 40days post fertilization (dpf) when immunoreactivity was ...
1. A scheme of synthesis was developped for cholecystokinin (CCK 26-33, using solid-phase methodology and successfully applied to the synthesis of its C- and N-terminal fragments. 2. Using CCK 30-33 as model, it was found that deprotection of the ?-phenacyl ester, with a 1 M solution of sodium thiophenoxide in DMF, leads to the formation of an aminosuccylnyl peptide, prior to ammonolysis. 3. Selenophenol reagent successfully removes the ?-phenacyl ester on protected CCK 32-33 and on protected CCK 30-33 polymer prior to ammonolytic cleavage of peptides from the resin. 4. Treatment of Boc-Asp(?-OPac)-Tyr(0-2,4-Dnp)-Met-Gly-Trp(Nin-For)-Met-Asp(?-OPac)-Phe-polymer with a 1 M solution of selenophenol in DMF, leads to irreversible rearrangement of the 0-2,4-dinitrophenyl ether. 5. Undesirable side-reactions can be avoided by sequential deprotections and cleavage. The 0-2,4-dinitrophenyl ether is removed by thiolysis following by selenolysis of the ?-phenacyl esters. Cleavage of the peptide from the ...
Looking for online definition of CCKAR or what CCKAR stands for? CCKAR is listed in the Worlds largest and most authoritative dictionary database of abbreviations and acronyms
This paper describes the chemical synthesis and CCK-B and CCK-A receptor binding affinities of a series of compounds in which the central amide bond of the CCK-B dipeptoid ligand tricyclo[3.3.1.1(3,7)]dec-2-yl [R-(R*,S*)]-[2-[[1-(hydroxymethyl)- 2-phenylethyl]amino]-1-(1H-indol-3-ylmethyl)-2-oxoet …
1. Niederau C, Lüthen R. The influence of CCK receptor antagonists on pancreatic feedback regulation. Internationales Symposium, Irsee, Bayern, Juni 1989. 2. Lüthen R, Niederau C, Niederau M, Borchard F, Strohmeyer G. Intrazelluläre Kompatimentierungsstörung bei experimenteller biliärer akuter Pankreatits. 44. Tagung der Dtsch. Ges. für Verdauungs- und Stoffwechselkrankheiten, Main, September 1989. Z Gastroentrol 1989, 27:536. 3. Niederau C, Lüthen R, Niederau M, Strohmeyer G. Langzeitwirkung von CCK-Stimulation und -Blockade auf Wachstum und Funktion des exokrinen Pankreas der Maus. 44. Tagung der Dtsch. Ges. für Verdauungs- und Stoffwechselkrankheiten, Mainz, September 1989. Z Gastroentrol 1989, 27:521. 4. Niederau M, Niederau C, Strohmeyer G, Lüthen R. Epidemiologie des Pankreaskarzinoms. 44. Tagung der Dt. Ges. f. Verdauungs- und Stoffwechselkrankheiten. September 89, Mainz. Z Gastroenterol 1989, 27:466. 5. Niederau C, Lüthen R, Niederau M, Strohmeyer G, Ferrell LD, Grendell JH. ...
TY - JOUR. T1 - Enzymatic Condensation of Cholecystikinin CCK-8(4-6) and CCK-8(7-8) Peptide Fragments in Organic Media. AU - Capellas, M.. AU - Caminal, G.. AU - López-Santín, J.. AU - Clapés, P.. AU - Gonzalez Anadon, Gloria. PY - 1997/1/1. Y1 - 1997/1/1. M3 - Article. VL - 56. SP - 456. EP - 463. IS - 4. ER - ...
GSK-7975A inhibits CRAC entry (Fura-2 340:380 normalized at 700 s). (A) Changes in mouse pancreatic acinar [Ca2+]C induced by CCK (1 nmol/L) with external physi
1KZW: Solution structure of human intestinal fatty acid binding protein with a naturally-occurring single amino acid substitution (A54T) that is associated with altered lipid metabolism