Dengue virus is a human pathogen that causes dengue fever, which can either resolve after mild fever or lead to severe dengue hemorrhagic fever/dengue shock syndrome. The role of dengue virus levels in the blood and the kinetics of infection and immune response that results in severe dengue disease in humans is not well characterized. In this study, we analyzed 97 children with varying degrees of dengue disease, and we show that the dengue virus quantity in blood does not show any significant association with severe disease. However, most severe dengue patients had lower levels of interferons and Th1 cytokines and increased levels of secreted factors such as IL-6, IL-8 and IL-10 that could potentially cause leakage in blood capillaries. Our results indicate that monocytes, which are infected with dengue virus in patients, could possibly play a major role in dengue pathogenesis. Furthermore, using computational analysis we identified association of some of the secreted factors with severe disease ...

TY - JOUR. T1 - Role of cognitive parameters in dengue hemorrhagic fever and dengue shock syndrome. AU - Tsai, Jih Jin. AU - Chokephaibulkit, Kulkanya. AU - Chen, Po Chih. AU - Liu, Li Teh. AU - Hsiao, Hui Mien. AU - Lo, Yu Chih. AU - Perng, Guey Chuen. PY - 2013/12/5. Y1 - 2013/12/5. N2 - Dengue is becoming recognized as one of the most important vector-borne human diseases. It is predominant in tropical and subtropical zones but its geographical distribution is progressively expanding, making it an escalating global health problem of today. Dengue presents with spectrum of clinical manifestations, ranging from asymptomatic, undifferentiated mild fever, dengue fever (DF), to dengue hemorrhagic fever (DHF) with or without shock (DSS), a life-threatening illness characterized by plasma leakage due to increased vascular permeability. Currently, there are no antiviral modalities or vaccines available to treat and prevent dengue. Supportive care with close monitoring is the standard clinical ...

Medical information, Dengue hemorrhagic fever. Definition of Dengue hemorrhagic fever, symptoms of Dengue hemorrhagic fever, treatment of Dengue hemorrhagic fever, and prevention of Dengue hemorrhagic fever. Exams and Tests Dengue hemorrhagic fever.

The dengue viruses are spread by mosquitoes and infect up to 390 million individuals annually in sub-tropical and tropical regions of the world. Dengue disease has emerged as the most important arthropod-borne viral disease of humans. Dengue virus infection generally results in dengue fever, a debilitating but self limited febrile disease. However, complications may arise, leading to the potentially fatal dengue haemorrhagic fever/dengue shock syndromes (DHF/DSS). Despite intensive research over recent years, the pathogenesis of DHF/DSS is still poorly understood and there is neither a safe and effective vaccine nor suitable anti-viral treatments to control dengue disease.. Current investigations in the laboratory focus on understanding the role of specific viral proteins in the virus lifecycle and the role they play in perturbing host cellular processes. Our studies use a dengue virus reverse genetic system, in combination with structural, biochemical and high throughput transcriptomic and ...

TY - JOUR. T1 - The exploration of risk factors of concurrent bacteraemia in patients critically ill with severe dengue. AU - Chen, Chin Ming. AU - Chan, Khee Siang. AU - Cheng, Kuo Chen. AU - Chou, Willy. AU - Chao, Hui Chun. AU - Yeh, Chiu Yin. AU - Yu, Wen Liang. PY - 2016/12/1. Y1 - 2016/12/1. N2 - We investigated the clinical features of intensive care unit (ICU) patients with concomitant severe dengue infection and bacteraemia to identify risk factors for this comorbidity. The records of all ICU dengue patients admitted during the period of 31 July-30 November 2015 were reviewed. Patients with concurrent bacteremia (positive bacterial blood culture within 72 h of ICU admission) were identified. ICU admission was required for 142 patients, of which 22 (15.5%) had concurrent bacteraemia. Species of the genus Streptococcus was the most common pathogens, followed by Escherichia coli then species of the genus Staphylococcus. Patients with a severe dengue infection and bacteraemia had higher ...

Dengue fever (DF) and dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS) are considered the most medically important and widespread mosquito-bor...

In a prospective study in the outpatients department of three large hospitals in Ho Chi Minh City, Viet Nam, we will determine the early diagnostic sensitivity, specificity, positive and negative predictive values of two NS1 diagnostic tests in severe dengue cases.. The study is intended to develop a prognostic algorithm for the early identification of severe dengue cases.. Routine demographic, haematological and biochemical laboratory markers will be utilized to derive a prognostic algorithm that is clinically-useful for guiding patient triage and interventions.. We hope to discover and evaluate new early biomarkers of severe dengue and will evaluate candidate host response molecules and virological markers for their prognostic value.. We further plan to understand the phylogeography of DENV in the super-urban setting of HCMC.. We will use genome scale sequencing of DENV together with geospatial information on the residential addresses of patients to better understand transmission dynamics in ...

The immunopathology of severe dengue remains incompletely understood. Most patients who develop severe dengue have had prior infection with one or more dengue serotypes. When an individual is infected... more

The immunopathology of severe dengue remains incompletely understood. Most patients who develop severe dengue have had prior infection with one or more dengue serotypes. When an individual is infected... more

Dengue shock syndrome: A syndrome due to the dengue virus that tends to affect children under 10, causing abdominal pain, hemorrhage (bleeding) and circulatory collapse (shock). Known also as dengue hemorrhagic fever (DHF), it starts abruptly with high continuous fever and headache plus respiratory and intestinal symptoms with sore throat, cough, nausea, vomiting, and abdominal pain. Shock occurs after 2 to 6 days with sudden collapse, cool clammy extremities, weak thready pulse, and blueness around the mouth (circumoral cyanosis). There is bleeding with easy bruising, blood spots in the skin (petechiae), spitting up blood (hematemesis), blood in the stool (melena), bleeding gums and nosebleeds (epistaxis). Pneumonia and heart inflammation (myocarditis) may be present. The mortality is appreciable ranging from 6 to 30%. Most deaths occur in children. Infants under a year of age are especially at risk of death. It is also called Philippine or Southeast Asian hemorrhagic fever. ...

In 2002, an outbreak of dengue fever (DF) in Taiwan caused mortality in some patients with chronic renal failure (CRF). We report three cases of CRF who died of dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS) despite an intensive care process. The difficulty in diagnosis and the treatment dilemma attributable to ambiguity in symptoms and signs between CRF and DF may delay the diagnosis, contributing to a high risk of mortality. The narrow window of fluid tolerance in patients with CRF further hampers the success of resuscitation in DHF and DSS. Continuous venous to venous hemodialysis (CVVHD) is helpful in managing a condition with unstable hemodynamics. However, to decrease mortality, the physician must pay great attention to ensure an early awareness of DHF/DSS and deliver a prompt and aggressive treatment of patients of dengue viral infections with chronic renal failure.

Dengue can cause plasma leakage that may lead to dengue shock syndrome (DSS). In approximately 30% of DSS cases, recurrent episodes of shock occur. These patients have a higher risk of fluid overload, respiratory distress and poor outcomes. We investigated the association of echocardiographically-derived cardiac function and intravascular volume parameters plus lactate levels, with the outcomes of recurrent shock and respiratory distress in severe dengue.We performed a prospective observational study in Paediatric and adult ICU, at the Hospital for Tropical Diseases (HTD), Ho Chi Minh City, Vietnam. Patients with dengue were enrolled within 12 hours of admission to paediatric or adult ICU. A haemodynamic assessment and portable echocardiograms were carried out daily for 5 days from enrolment and all interventions recorded. 102 patients were enrolled; 22 patients did not develop DSS, 48 had a single episode of shock and 32 had recurrent shock. Patients with recurrent shock had a higher enrolment pulse

Dengue virus rarely causes death. However, the infection can progress into a more serious condition known as severe dengue or dengue hemorrhagic fever.

The dogma of the antibody-dependent enhancement model (ADE) for the development of dengue hemorrhagic fever (DHF) is being challenged by research published this week in PLoS Medicine.

Get natural cures for Dengue Hemorrhagic Fever that can make a difference in your life or the life of someone you love with alternative treatments.

Journal of Clinical and Diagnostic Research aims to publish findings of doctors at grass root level and post graduate students, so that all unique medical experiences are recorded in literature.

臺大位居世界頂尖大學之列，為永久珍藏及向國際展現本校豐碩的研究成果及學術能量，圖書館整合機構典藏（NTUR）與學術庫（AH）不同功能平台，成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。. To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of NTU Repository with Academic Hub to form NTU Scholars.. ...

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Giving red guava juice as a way to increase platelet arguably have become tradition in the community when stricken with dengue hemorrhagic fever (DHF). Because, during the treatment of DHF patients continues to be supportive, that is to overcome the plasma fluid loss due to increased permeability of capillary blood vessels. Doctor Ety from RS Mitra Keluarga states, red guava juice only improve your physical condition in order to keep fit, so avoid the attack of DHF. There was no correlation between red guava juice and DHF ...

This report describes a new, rapid, sensitive, and quantitative method for the detection of immune complexes, endotoxins, and other complement activating materials in patients sera utilizing the ability of these substances to react with isolated C1q. The procedure is based on the inhibition of radiolabeled C1q binding to sensitized sheep erythrocytes by C1q-reactive substances in pathological sera. The C1q deviation test may be performed on 50 mu1 of serum, using 1 mug of radiolabeled C1q per sample. The procedure may be completed in 1.5-2 h, it is capable of detecting 5 mug of aggregated human IgG per ml of serum, and its coefficient of variation is 4.2%. Application of the test to the study of 193 sera from 43 patients with Dengue hemorrhagic fever showed a positive correlation between degree of C1q deviation and severity of disease. ...

Libraty DH, Zhang L, Woda M, Giaya K, Kathivu CL, Acosta LP, Tallo V, Segubre-Mercado E, Bautista A, Obcena A, Brion JD, Capeding RZ. Low adiposity during early infancy is associated with a low risk for developing dengue hemorrhagic fever: a preliminary model. PLoS One. 2014; 9(2):e88944 ...

High prevalence of hepatitis B virus (HBV) infection in China offers a unique setting to examine HBVs influence on the presentation of dengue fever. In 398 patients admitted for suspected dengue fever, 89% (353/398) were positive for dengue IgM antibodies. Among dengue-infected patients, 8% (29/353) had chronic HBV co-infection. Only dengue virus serotype 1 was identified by virus isolation and reverse transcriptase-polymerase chain reaction assays. No case of dengue hemorrhagic fever/dengue shock syndrome was diagnosed. In addition to routine clinical tests, inter-leukin 2 (IL-2), IL-4, IL-6, IL-10, interferon γ (IFNγ), and tumor necrosis factor α (TNFα) levels were measured in the sera of 95% (334/353) of dengue-infected subjects as well as controls. Surprisingly, HBV/dengue co-infected patients made less IL-6 (P < 0.05) and TNFα (P < 0.05) than patients with only dengue infection. Similar levels of IL-4, IL-10, and IFNγ were found in both groups. Thus, HBV co-infection seems to alter the

Scanning electron microscopy of the four larval instars of the Dengue fever vector Aedes aegypti (Diptera: Culicidae). Stefan Schaper1 & Francisco Hernández-Chavarría2. 1 Institute for Zoology, Tierärztliche Hochschule Hannover, Germany and Universidad Nacional, Heredia, Costa Rica.. 2 Centro de Investigación en Estructuras Microscópicas and Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica; [email protected]. Received 09-IV-2003. Corrected 16-IX-2005. Accepted 23-III-2006.. Abstract: Aedes aegypti is the main insect vector of Dengue fever and dengue hemorrhagic fever/dengue shock syndrome and represents the only vulnerable element in the control of this disease. Therefore, the identification and quantification of this mosquito is an important task; however, the majority of taxonomic keys are based on the 4th larval instar. For that reason, this study describes the four larval instars of A. aegypti using scanning electron microscopy. Morphological changes ...

Dengue has a broad spectrum of clinical symptoms, ranging from asymptomatic infection, undifferentiated fever and dengue fever (DF) to dengue hemorrhagic fever (DHF) or dengue shock syndrome (DSS). DHF and DSS are the most severe forms of the disease, as they involve bleeding and hypovolemic shock and may lead to death if they are not diagnosed early and treated correctly. Every year, about 36 million cases of DF, of which about 2.1 million cases are DHF/DSS resulting in 21,000 deaths among children and young adults, are reported. Dengue not only has negative effects on public health worldwide but also poses significant economic burden. However, no licensed vaccines or (specific) anti-viral therapies for prevention or treatment of dengue are available. Thus, timely diagnosis and an accurate prognosis of severe dengue in the first few days of illness for clinical triage, treatment management, disease surveillance and research activities are vital and very helpful. We conducted three studies ...

New results from an early-stage clinical trial of a dengue vaccine co-developed by researchers at the University of Vermont (UVM), Johns Hopkins University and the National Institutes of Health, bring positive news for the reported 50 to 100 million individuals infected annually with the deadly virus. According to the findings, the vaccine is safe and stimulates a strong immune response in most vaccine recipients.. The study appears in the March 15, 2013 issue of the Journal of Infectious Diseases.. Transmitted to humans by Aedes mosquitoes and prevalent in many tropical and subtropical regions of the world, dengue infection is caused by any of four related viruses: Dengue viruses (DENV) 1 through 4. Classically described dengue fever includes fever, headache, severe joint and muscle pain, and rash. Severe dengue infections, dengue hemorrhagic fever, and dengue shock syndrome include a higher risk of complications and death and are more commonly seen after a second infection with dengue viruses. ...

Effect of Dengue Hemorrhagic Fever on Thrombomodulin Level - Free download as PDF File (.pdf), Text File (.txt) or read online for free. Effect of Dengue Hemorrhagic Fever on Thrombomodulin Level

A novel coronavirus, SARS-CoV-2 was identified in Wuhan, China. The disease caused by the virus can range in severity from asymptomatic to acute respiratory distress syndrome (ARDS) and death. Primary dengue infection results in IgE mediated sensitization against dengue virus (DENV) proteins. These IgE bind to receptors on mast cells. Upon subsequent exposure to the antigen recognized by the IgE, mast cell degranulation occurs releasing mediators such as histamine. Therefore secondary dengue infection results in urticaria, increased vascular permeability, hypotension, dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). A case of

2) Haemoconcenteration (increase in haematocrit by 20% or more over baseline).. What are the clinical features of Dengue shock syndrome?. The patient with dengue shock syndrome presents with history of fever for 2-7 days Then the condition of the patient deteriorates as the fever begin to fall .The patient then may show signs of circulatory failure as the skin becomes cold ,blotchy and congested. Ultimately the patient may enter a critical stage of shock.. What are the factors responsible for dengue fever outbreaks?. The occurrence of DF outbreaks is linked to number of factors such as density of vector (Aedes aegypti), source (an infected febrile person) and presence of susceptible hosts in the community.. What factors increase the density of Aedes aegypti?. Aedes aegypti is commonly found in urban dwellings ,both indoors and outdoors. Therefore, fast urbanization and dense population facilitates the progress of outbreak. ...

Abstract: Human leukocyte antigen (HLA) alleles have been correlated with susceptibility or resistance to severe dengue; however, few immunogenetic studies have been performed in Latin American (LA) populations. We have conducted immunogenetic studies of HLA class I and II alleles in a cohort of 187 patients with DENV-3 infection and confirmed clinical diagnosis of either severe dengue, known as dengue hemorrhagic fever (DHF), or the less severe form, dengue fever (DF), in Recife, Pernambuco, Brazil. An association analysis was performed using Fishers association test, with odds ratios (ORs) calculated using conditional maximum likelihood estimates. HLA-B*44 (P=0.047, OR = 2.025, 95% CI = 0.97-4.24) was found to be associated with increased susceptibility to DHF in response to DENV-3 infection. In addition, HLA-B*07 (P=0.048, OR = 0.501, one-sided 95% CI = 0-0.99) and HLA-DR*13 (P=0.028, OR = 0.511, one-sided 95% CI = 0-0.91) were found to be associated with resistance to secondary dengue ...

Dengue virus (DENV) is an arthropod-borne virus (family Flaviviridae) causing dengue fever or dengue hemorrhagic fever. Here, we report the first fatal DENV infection imported into Germany. A female traveler was hospitalized with fever and abdominal pain after returning from Ecuador. Due to a suspec …

Dengue and Dengue Hemorrhagic Fever | Duane J. Gubler, Eng Eong Ooi, Subhash Vasudevan, Jeremy Farrar | download | B-OK. Download books for free. Find books

Since Dengue fever (DF) and its related forms, Dengue Hemorrhagic fever (DHF) and Dengue Shock Syndrome (DSS) have become important health concerns worldwide, it is also imperative to develop methods which will help in the analysis of the incidences. Dengue fever cases are growing in number as it also invades widely, affecting larger number of countries and crossing climatic boundaries. Considering that the disease as of now has neither an effective vaccine nor a cure, monitoring in order to prevent or control is the resorted alternative. GIS and its related technologies offer a wealth of interesting capabilities towards achieving this goal.. The intention of this study was to develop methods to describe dengue fever outbreaks taking Rio de Janeiro, Brazil as a case study. Careful study of Census data with appropriate attributes was made to find out their potential influence on dengue fever incidence in the various regions or census districts. Dengue incidence data from year 2000 to year 2008 ...

Dengue fever does not have a specific treatment plan. Symptoms of dehydration, fever, body pains, nausea, and vomiting may be present. These can be treated with rest, plenty of fluids, and Tylenol. However, if you become infected, you should visit a doctor, since conditions and resulting appropriate treatment can vary. Additionally, dengue can manifest in two severe forms, dengue hemorrhagic fever and dengue shock syndrome, which have more serious effects, like bleeding and shock, so getting medical attention is important.. ...

Vector-borne diseases continue to plague us. The worst is malaria, transmitted by anopheline mosquitoes, killing many hundreds of thousands of people every year, mostly infants and children in tropical Africa [1]. The best existing methods of control-artemisinin-based drug treatment and mosquito control with chemical sprays and treated bednets-can reduce the burden of disease substantially, and can even eliminate the disease in some regions, but are not thought capable of globally eradicating the disease [2,3]. It is not even clear that current levels of efficacy can be maintained, given the likelihood of parasites and mosquitoes evolving resistance, and immunity waning as a result of partial control [3,4]. Dengue fever is another important mosquito-borne disease: caused by a virus originating in the jungles of southeast Asia, more than 100 countries have now been affected by dengue outbreaks, and the incidence of its most severe forms (dengue haemorrhagic fever and dengue shock syndrome) has ...

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Abu Bakar, Maidin (1990) Nama-nama Melayu : masalah dalam penyusunan. Kekal Abadi.. Alias, M. (1990) Malay political and PAS political struggles. Jurnal Pengajian Melayu, 2. pp. 90-107. ISSN 1823-7622. Arokiasamy, J.T. (1990) Nutritional problems of Malaysian children and approaches taken to overcome them. Asia-Pacific journal of public health / Asia-Pacific Academic Consortium for Public Health, 4 (1). pp. 65-71. ISSN 1010-5395. Chan, S.N. (1990) Sources of consumer health information in Malaysia. Kekal Abadi, 9 (2).. Fong, M.Y.; Koh, C.L.; Samuel, S.; Pang, T.; Lam, S.K. (1990) Nucleotide sequences of the nonstructural protein NS1 gene of three dengue-2 viruses, M1, M2 and M3, isolated in Malaysia from patients with dengue haemorrhagic fever, dengue shock syndrome and dengue fever, respectively. Nucleic acids research, 18 (6). p. 1642. ISSN 0305-1048. Ghani, W.M.; Razak, I.A.; Yang, Y.H.; Talib, N.A.; Ikeda, N.; Axell, T.; Gupta, P.C.; Handa, Y.; Abdullah, N.; Zain, R.B. (1990) Factors ...

Results The PICU had 10 beds, 7 ventilators and 1 haemodialysis machine. There was a shortage of staff with only 1 doctor and 2 nurses at night. Routine investigations were available although microbiology culture was rarely performed.. 407 patients were admitted with the majority being infants (range 0-16 years). The furthest distance travelled was 907 Km for a child with lead poisoning. Most patients were admitted for less than 5 days. The peak admission period was during the rainy season which corresponds to the peak incidence of dengue. 64 patients (17.5%) presented with dengue shock syndrome or dengue haemorrhagic fever.. The principle reasons for admission included status epilepticus (26.5%); pneumonia (20%); dengue (17.5%); multi-organ failure (14.2%); septicaemic shock (11.7%); and encephalitis (9.5%). Other important reasons for admission were meningitis; gastroenteritis; post-measles complications; diphtheria; snake bite; Beriberi (including Wernicke´s encephalopathy); tetanus; rabies; ...

This book has been completely revised and practically rewritten reflecting the advances in the practice of pediatric emergency care. The book is divided into eight sections including those on Organization of Emergency Department, Resuscitation and Life-threatening Emergencies, Pediatric Medical Emergencies, Environmental Problems, Toxicological Emergencies, Neonatal Emergencies, Pediatric Surgical Emergencies, and Pediatric Emergency Procedures. Notable additions include chapters focussing on Ethical and Legal Issues in Emergency Care, Oxygen Therapy, Respiratory Failure, Approach to a Comatose Patient, Fluid and Electrolyte Disturbances, Blood Component Therapy, Initial Management of Life-threatening Problems in Severely Malnourished Children, Fever without a Focus, Dengue Hemorrhagic Fever and Dengue Shock Syndrome, Severe Falciparum Malaria and Acute Paralysis. New Chapter on Approach to a Child with Trauma, Gynecological, Rheumatological, Endocrine, Neonatal Surgical and Urological Emergencies

The symptoms are sore throat, gum bleeding, nose bleeding, abdominal pain and flat rashes, usually on the legs. Gatchalian cites the fever can last from two to seven days. If it persists, complications have occurred. Another characteristic is the saddleback fever. When you think the fever has gone, it comes back after 12 hours, she says.. The doctors request Dengue NS1, the standard test which includes the patients complete blood count, to check for blood plasma leakage, level of platelets and blood typing. Extremely low blood pressure can lead to dengue shock syndrome. Still, negative results dont rule out dengue. If the patient shows symptoms, he will be treated as a dengue case.. With dengue, the virus attacks the blood vessels. It increases the capillary permeability, that is, the fluid from the blood comes out. You need to hydrate. When the fever is gone, you need to observe the first 48 hours after it disappears. Sometimes the patient goes in shock, Gatchalian says.. Peak incidences ...

The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.. ...

Jeremy Farrar is director of the Wellcome Trust-funded Oxford University Clinical Research Unit. Over the past ten years he has created a remarkable research institute in which his own research productivity has been phenomenal and an impressive training program has been developed. Under his direction the research programme has conducted seminal work on malaria, dengue, typhoid, tetanus, pyogenic and tuberculous meningitis and has become the leading centre for clinical research on avian influenza. These Pivotal clinical and virological studies have identified the dual importance of viral burden and the cytokine response to the lethal pathogenesis of avian influenza, and have described the rapid emergence of resistance to neuraminidase inhibitors. The unit has also conducted important research into Dengue shock syndrome, conducting the only large prospective randomised trials of fluid replacement and has provided an evidence-base for revision of the World Health Organisation classification. His ...

The criteria in Surviving Sepsis Campaign Guideline for blood transfusion, i.e., hematocrit of ,30% is not applicable to severe dengue. In fact, blood transfusion is life-saving and should be given as soon as severe bleeding is suspected or recognized. Do not wait for the haematocrit to drop too low before deciding on blood transfusion. This is because, in dengue, bleeding usually occurs AFTER a period of prolonged shock that is preceded by plasma leakage. During the plasma leakage the hematocrit IN FACT, increases to relatively high values before the onset of severe bleeding. As a result, when bleeding occurs in the later stage, hematocrit will then drop from this higher level; and therefore, it may not be as low as in the absence of plasma leakage ...

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The baby died at around 7.30 PM and the cause of the babys death was bilateral pneumonia with septic shock in a case of severe Dengue, a senior doctor at the institute said quoting from the death certificate issued.. The baby, a resident of the Kareya area in the city, was admitted at the paediatric institute yesterday after being referred by a nursing home.. ...

Dengue Hemorrhagic Fever (DHF) - is a more severe form, seen only in a small proportion of those infected. DHF is a stereotypic illness characterized by 3 phases; febrile phase with high continuous fever usually lasting for less than 7 days; critical phase (plasma leaking) lasting 1-2 days usually apparent when fever comes down, leading to shock if not detected and treated early; convalescence phase lasting 2-5 days with improvement of appetite, bradycardia (slow heart rate), convalescent rash (white patches in red background), often accompanied by generalized itching (more intense in palms and soles), and diuresis (increase urine output ...

Principal Investigator：ISOMURA Shin, Project Period (FY)：1996, Research Category：Grant-in-Aid for international Scientific Research, Section：Field Research

Dengue, Influenza, Disease, Fever, Infection, Patients, Risk, Hiv, Epidemic, Dengue Hemorrhagic Fever, Pandemic, Infections, Health, Hospital, Virus, Hiv-1, Populations, PCR, Confidence Interval, Healthcare

The World Health Organization estimates that dengue virus causes more than 50 million cases of dengue fever a year. Dengue virus infection is the leading cause of hospitalization and death in children of most tropical Asian countries. There are four different serotypes of dengue virus. Most cases of dengue hemorrhagic fever/dengue shock syndrome are caused by secondary infection with a dengue serotype different from the first serotype the individual was infected with. A vaccine that would be effective in preventing infection by multiple dengue serotypes is desirable. The purpose of this study is to determine the safety of and immune response to two different dengue virus vaccines in individuals who have been previously vaccinated against a different serotype.. This study will last at least 42 days. Participants will be recruited from a database of previous dengue vaccine recipients and will be stratified by the type of vaccine previously received. Participants assigned to Cohort 1 and Cohort 2 ...

BACKGROUND: Dengue virus is endemic in tropical and sub-tropical resource-poor countries. Dengue illness can range from a nonspecific febrile illness to a severe disease, Dengue Shock Syndrome (DSS), in which patients develop circulatory failure. Earlier diagnosis of severe dengue illnesses would have a substantial impact on the allocation of health resources in endemic countries. METHODS AND FINDINGS: We compared clinical laboratory findings collected within 72 hours of fever onset from a prospective cohort children presenting to one of two hospitals (one urban and one rural) in Thailand. Classification and regression tree analysis was used to develop diagnostic algorithms using different categories of dengue disease severity to distinguish between patients at elevated risk of developing a severe dengue illness and those at low risk. A diagnostic algorithm using WBC count, percent monocytes, platelet count, and hematocrit achieved 97% sensitivity to identify patients who went on to develop DSS while

Last week the World Health Organization (WHO) reported that dengue is the worlds fastest-spreading tropical disease. As reported by Reuters, dengue is a threat that is present in more than 125 countries.. The WHO estimates that 50 and 100 million dengue infections occur worldwide every year, but acknowledges that this is likely a conservative figure. The CDC estimates that about 2.5 billion people, or 40% of the worlds population, live in areas where there is a risk of dengue transmission. The areas in which dengue is endemic include Asia, Africa and Latin America, but it is present on all continents.. Dengue fever is caused by any one of four dengue virus serotypes and is transmitted by the Aedes aegypti and Aedes albopictus mosquito species. Infection with one serotype does not provide immunity against other dengue serotypes, and multiple infections put people at risk for dengue hemorrhagic fever and dengue shock syndrome. Dengue symptoms typically begin four to seven days following the ...

|i|Introduction.|/i| Dengue fever is an arboviral disease, which is transmitted by mosquito vector and presents as varied clinical spectrum of dengue fever (DF), dengue hemorrhagic fever (DHF), dengue shock syndrome (DSS), and expanded dengue syndrome (EDS) with atypical presentations, thus posing a diagnostic dilemma. Unless we are aware of these presentations, diagnosis as well as early initiation of treatment becomes difficult. We studied the various clinical presentations of dengue infection during an outbreak of disease in 2015.|i| Materials and Methods|/i|. A total of 115 confirmed cases of dengue infection from Department of Medicine of Deen Dayal Upadhyay Hospital, New Delhi, were enrolled in this observational study.|i| Results.|/i| The common signs and symptoms of dengue infection were fever, headache, body ache, backache, retro-orbital pain, bleeding manifestations, and rash in 100%, 87%, 86%, 58%, 41%, 21%, and 21%, respectively. Nonspecific or warning

Dengue is not transmitted directly from person-to-person. Instead, it is transmitted by the bite of a mosquito infected with one of the four dengue virus serotypes. It is a febrile illness that affects infants, young children and adults. Symptoms range from mild fever to incapacitating high fever with rash, severe headache, pain behind the eyes, as well as muscle and joint pain. The disease is also known as breakbone fever due to the severe pain it can cause. Severe dengue (also known as dengue hemorrhagic fever) affects mainly children, and is characterized by fever, abdominal pain, persistent vomiting, bleeding and breathing difficulty - it is potentially deadly.. The WHO estimates that about half of the worlds population is now at risk. However, at this time, there is no licensed vaccine or any specific medicine to treat dengue. Fortunately, there is hope. Several vaccines are in the final steps of development, with the one produced by the French pharmaceutical company Sanofi Pasteur ...

The Philippines and Thailand share a common history when it comes to dengue because it was in these two countries where the dengue hemorrhagic fever, a lethal complication of dengue fever, was first reported and identified in the 1950s.. Fifty-eight years later, dengue fever has become a major international public health concern considering that majority of those affected are children ages between one and 10 years old.. Hospitalized. Though dengue fever is usually not a fatal disease, young patients are more likely to be hospitalized especially if they develop high fever, severe headache, strain in muscles and rashes.. If left unmanaged, dengue fever could kill up to 20 percent of those infected as the patient develops life-threatening conditions like bleeding, low levels of blood platelets and blood plasma leakage (dengue hemorrhagic fever) and circulatory failure (dengue shock syndrome).. According to Dr. Lyndon Lee Suy, program manager of the Department of Healths Emerging and Reemerging ...

In the 20th century dengue fever became one of the leading causes of morbidity and mortality throughout the tropics. The dengue virus is an arbovirus transmitted by Aedes mosquitoes. There are four distinct serotypes of dengue arbovirus (DENV-1, 2, 3, 4). According to the World Health Organization, a person infected by one of the dengue viruses can develop symptoms ranging from the classical self-limiting form characterized by high temperature, headache, myalgia, and arthralgia to the severe, potentially fatal, form known as dengue shock syndrome. For over 40 years the main explanation for the pathogenesis of dengue has been based on the antibody-dependent enhancement (ADE) concept stating that enhancing antibodies acquired during a primary infection increase the number of infected cells, and thus the level of viremia, during secondary infection. However the severity of dengue is not limited to dengue shock syndrome and there are many cases that do not conform to the ADE concept. A meta-analysis could

Dengue fever is a severe health problem in tropical areas, with two-thirds of the world population at risk of infection (24). Four virus serotypes and even more quasispecies can be differentiated both in the transmitting insect (A. aegypti) and in the blood of patients with acute dengue fever (26). During recent decades Europe has been free of dengue infections, but as a result of increasing tourism every year several thousand tourists return to European countries with acute dengue fever.. In the second half of 1998 we diagnosed 172 dengue patients. All patients were European tourists, most of whom had experienced a disease with high fever and headache for several days. Usually early serum samples were taken 4 to 8 days after the onset of symptoms. Therefore, early serum samples without dengue virus antibodies at all or with either IgG or IgM antibodies were obtained from only 25 patients (15%). In 20 early samples viral RNA could be demonstrated by TaqMan PCR, in one case even in the presence ...

TY - JOUR. T1 - Antibodies against thrombin in dengue patients contain both anti-thrombotic and pro-fibrinolytic activities. AU - Chuang, Yung Chun. AU - Lin, Yee Shin. AU - Liu, Hsiao Sheng. AU - Wang, Jen Reng. AU - Yeh, Trai Ming. PY - 2013. Y1 - 2013. N2 - Dengue virus (DENV) infection may result in severe life-threatening Dengue haemorrhagic fever (DHF). The mechanisms causing haemorrhage in those with DHF are unclear. In this study, we demonstrated that antibodies against human thrombin were increased in the sera of Dengue patients but not in that of patients infected with other viruses. To further characterise the properties of these antibodies, affinity-purified anti-thrombin antibodies (ATAs) were collected from Dengue patient sera by thrombin and protein A/L affinity columns. Most of the ATAs belonged to the IgG class and recognized DENV nonstructural protein 1 (NS1). In addition, we found that dengue patient ATAs also cross-reacted with human plasminogen (Plg). Functional studies in ...

Abstract. Dengue virus (DENV) infection usually presents with mild self-limiting dengue fever (DF). Few however, would present with the more severe form of the disease, dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). In the present study, the association between IL-12B, IL-10 and TNF-α gene polymorphisms and dengue severity was investigated. Methods: A case-control study was performed on a total of 120 unrelated controls, 86 DF patients and 196 DHF/DSS patients. The polymorphisms in IL-12B, IL-10 and TNF-α genes were genotyped using PCR-RFLP and PCR-sequencing methods. Results: A protective association of TNF-α -308A allele and -308GA genotype against DHF/DSS was observed, while TNF-α -238A allele and -238GA genotype were associated with DHF/DSS. A combination of TNF-α -308GA+AA genotype and IL-10 non-GCC haplotypes, IL-12B pro homozygotes (pro1/pro1, pro2/pro2) and IL-12B 3UTR AC were significantly correlated with protective effects against DHF/DSS. An association between ...

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AFUCOSYLATED MATERNAL ANTI-DENGUE IGGS ARE A BIOMARKER FOR SUSCEPTIBILITY TO SEVERE DENGUE DISEASE IN INFANTS. Researchers at Stanford, funded in part by the Chan Zuckerberg Biohub, have developed a method for determining infant susceptibility to severe dengue disease through measurement of maternal anti-dengue IgG. Mortality rates in severe dengue disease can exceed 20% when patients are not hospitalized but can be reduced to less than 1% with inpatient care. Therefore, the identification of biomarkers for increased susceptibility to dengue disease could dramatically reduce mortality rates by enabling early hospitalization of those at highest risk for disease progression. Here, the inventors conducted a global analysis of anti-dengue IgGs from mothers of infants with known disease severity during primary dengue infections in order to identify features of maternal IgGs that indicate dengue disease risk in infants.. Stage of Research The glycosylation state of the IgG Fc domain plays a role in ...

Death because of fever is increasing day by day. Dengue fever is the main type of fever which leads to this increased mortality rate It is important to prevent the disease. if the disease caused have to be treated properly. Proper medicine and the rest is the main defensive way to prevent dengue fever dengue fever is also called break bone fever. Dengue fever is a viral disease the dengue virus which is spread by mosquito is the main reason behind dengue fever.. If once dengue fever host it will make antibodies over the body for the lifetime the first time of dengue fever is known as Type 1 dengue fever is Dengue fever caused more than one time then then it would be type 2 dengue fever.. ...

Dengue is fast emerging pandemic-prone viral disease in many parts of the world. Dengue flourishes in urban poor areas, suburbs and the countryside but also affects more affluent neighbourhoods in tropical and subtropical countries.. Dengue is a mosquito-borne viral infection causing a severe flu-like illness and, sometimes causing a potentially lethal complication called severe dengue. The incidence of dengue has increased 30-fold over the last 50 years. Up to 50-100 million infections are now estimated to occur annually in over 100 endemic countries, putting almost half of the worlds population at risk.. Severe dengue (previously known as dengue haemorrhagic fever) was first recognized in the 1950s during dengue epidemics in the Philippines and Thailand. Today it affects Asian and Latin American countries and has become a leading cause of hospitalization and death among children and adults in these regions.. The full life cycle of dengue fever virus involves the role of mosquito as a ...

1 PengertianDengue Fever (DF) adalah penyakit demam akut selama 2-7 hari dengan dua atau lebih manifestasi berikut: nyeri skepala,nyeri perut, mual, muntah, nyeri retro orbital, myalgia, atralgia, ruam kulit, hepatomegali, manifestasi perdarahan, danlekopenia.Dengue Haemoragic Fever (DHF) adalah penyakit demam akut yang disertai dengan adanya manifestasi perdarahan, yangbertendensi mengakibatkan renjatan yang dapat menyebabkan kematian (Arief Mansjoer &Suprohaita; 2000).Dengue Haemoragic Fever (DHF) adalah infeksi akut yang disebabkan oleh Arbovirus (arthropodborn virus) dan ditularkanmelalui gigitan nyamuk Aedes Aegypti dan Aedes Albopictus. (Ngastiyah, 1995).Dengue Haemoragic Fever (DHF) adalah suatu penyakit infeksi yang disebabkan oleh virus dengue dengan tipe I - IVdengan infestasi klinis dengan 5 - 7 hari disertai gejala perdarahan dan jika timbul tengatan angka kematiannya cukuptinggi (UPF IKA, 1994).Dengue Hemoragik Fever (DHF) adalah kasus demam dengue dengan kecenderungan perdarahan ...

Currently, several assays can diagnose acute dengue infection. However, none of these assays can predict the severity of the disease. Biomarkers that predicts the likelihood that a dengue patient will develop a severe form of the disease could permit more efficient patient triage and allows better supportive care for the individual in need, especially during dengue outbreaks. We measured 20 plasma markers i.e. IFN-γ, IL-10, granzyme-B, CX3CL1, IP-10, RANTES, CXCL8, CXCL6, VCAM, ICAM, VEGF, HGF, sCD25, IL-18, LBP, sCD14, sCD163, MIF, MCP-1 and MIP-1β in 141 dengue patients in over 230 specimens and correlate the levels of these plasma markers with the development of dengue without warning signs (DWS−), dengue with warning signs (DWS+) and severe dengue (SD). Our results show that the elevation of plasma levels of IL-18 at both febrile and defervescence phase was significantly associated with DWS+ and SD; whilst increase of sCD14 and LBP at febrile phase were associated with severity of dengue disease

Dengue virus (DENV) is a mosquito-borne flavivirus responsible for life-threatening dengue haemorrhagic fever (DHF) and dengue shock syndrome (DSS). The viral replication machinery containing the core non-structural protein 5 (NS5) is implicated in severe dengue symptoms but molecular details remain obscure. To date, studies seeking to catalogue and characterize interaction networks between viral NS5 and host proteins have been limited to the yeast two-hybrid system, computational prediction and co-immunoprecipitation (IP) of ectopically expressed NS5. However, these traditional approaches do not reproduce a natural course of infection in which a number of DENV NS proteins colocalize and tightly associate during the replication process. Here, we demonstrate the development of a recombinant DENV that harbours a TAP tag in NS5 to study host-virus interactions in vivo. We show that our engineered DENV was infective in several human cell lines and that the tags were stable over multiple viral passages,

Dengue is a mosquito-borne disease caused by the dengue viruses. There are four distinct but related virus serotypes all of which can cause dengue fever or the more serious forms of the disease, dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS).

Dengue fever is a mosquito-borne tropical disease caused by the dengue virus. Symptoms typically begin three to fourteen days after infection. This may include a high fever, headache, vomiting, muscle and joint pains, and a characteristic skin rash. Recovery generally takes two to seven days. In a small proportion of cases, the disease develops into the life-threatening dengue hemorrhagic fever, resulting in bleeding, low levels of blood platelets and blood plasma leakage, or into dengue shock syndrome, where dangerously low blood pressure occurs. Dengue is spread by several species of mosquito of the Aedes type, principally A. aegypti. The virus has five different types; infection with one type usually gives lifelong immunity to that type, but only short-term immunity to the others. Subsequent infection with a different type increases the risk of severe complications. A number of tests are available to confirm the diagnosis including detecting antibodies to the virus or its RNA. A novel vaccine ...

As of Feb. 6, there were 12,904 suspected cases of dengue reported in 2016, including 49 deaths. This is slightly higher than that reported during the same period in 2015 when 12,766 cases were reported.. Dengue is an important arboviral infection that continues to cause a substantial public health burden in Asia and the Pacific.. Dengue is transmitted by the bite of a mosquito infected with one of the four dengue virus serotypes. It is a febrile illness that affects infants, young children and adults with symptoms appearing 3-14 days after the infective bite.. Dengue is not transmitted directly from person-to-person and symptoms range from mild fever, to incapacitating high fever, with severe headache, pain behind the eyes, muscle and joint pain, and rash.. Related: Dengvaxia now available in the Philippines: Sanofi Pasteur. Severe dengue (also known as dengue hemorrhagic fever) is characterized by fever, abdominal pain, persistent vomiting, bleeding and breathing difficulty and is a ...

Dengue fever and dengue hemorrhagic fever (DHF) are acute febrile diseases, found in the tropics and Africa, and caused by four closely related virus serotypes of the genus Flavivirus, family Flaviviridae.The geographical spread is similar to malaria, but unlike malaria, dengue is often found in urban areas of tropical nations, including Singapore, Taiwan, Indonesia, Philippines, India and Brazil. Each serotype is sufficiently different that there is no cross-protection and epidemics caused by multiple serotypes (hyperendemicity) can occur. Dengue is transmitted to humans by the Aedes aegypti (rarely Aedes albopictus) mosquito, which feeds during the day.. Dengue (DF) and dengue hemorrhagic fever (DHF) are caused by one of four closely related, but antigenically distinct, virus serotypes (DEN-1, DEN-2, DEN-3, and DEN-4), of the genus Flavivirus. Infection with one of these serotypes provides immunity to only that serotype for life, so persons living in a dengue-endemic area can have more than ...

Research recently published in PLoS Medicine challenges the dogma of the antibody-dependent enhancement model (ADE) for the development of dengue hemorrhagic fever (DHF). Dengue virus infection usually causes a severe flu like illness, although symptoms may be mild in young children. DHF, however, is a severe and sometimes fatal complication of dengue virus infection that affects about half a million people every year. DHF patients usually fall into two groups; children and adults who become infected with a second dengue virus serotype after an initial primary dengue virus infection with a different serotype, and infants with primary dengue virus infections born to mothers who have some dengue virus immunity. The current model for development of DHF in infants around 6 months old is that anti-dengue virus antibodies transferred from a dengue-immune mother to her child somehow enhance dengue virus infection, resulting in more severe symptoms (the antibody-dependent enhancement model). A ...

Schon mal was von dem gefährlichen Virus Denguefieber gehört? Mindestens genauso ansteckend ist der treibende Cumbia-Future-Sound des Duos Dengue Dengue Dengue! aus der peruanischen Millionenmetropole Lima. Mit wobbeligen Bässen ausgeliehen aus dem Dubstep, futuristischen Sounds seziert aus dem Techno und psychedelischen Sounds inspiriert aus der 70er Jahre Cumbia-Chicha hebt Dengue Dengue Dengue! den Cumbia-Digital Sound auf ein neues Level. Auf den Live-Shows von Dengue Dengue Dengue! bekommt man das Gefühl mit einem UFO direkt auf dem peruanischen Inkatempel Machu-Pichu zu landen - inmitten eines futuristischen Technoraves mit Ausblick über den amazonischen Urwald. Dengue Dengue Dengue! ist ein junges Duo bestehend aus Felipe Salmon und Rafael Pereira. Beide sind auch Teil des Colectivo Auxiliar, ein peruanisches Sound-Laboratorium. Der Name Dengue Dengue Dengue! entspringt einer Enrique Lynch Platte, der darauf einen Rhythmus spielt, der sich Dengue nennt. Das Projekt überzeugt von ...

In some cases, Dengue infection is asymptomatic - persons do not exhibit symptoms. Those with symptoms get ill between 4 to 7 days after the bite. The infection is characterized by flu-like symptoms which include a sudden high fever coming in separate waves, pain behind the eyes, muscle, joint, and bone pain, severe headache, and a skin rash with red spots. Treatment includes supportive care of symptoms. There is no antiviral treatment available. The illness may progress to Dengue Hemorrhagic Fever (DHF). Symptoms include severe abdominal pain, vomiting, diarrhea, convulsions, bruising, and uncontrolled bleeding. High fever can last from 2 to 7 days. Complications can lead to circulatory system failure and shock, and can be fatal (also known as Dengue Shock Syndrome).. If you are infected with the same Dengue virus serotype you become immune to future infections. However, if you are infected subsequently with a different serotype, immunity wanes over time which increases the risk of developing ...

In some cases, Dengue infection is asymptomatic - persons do not exhibit symptoms. Those with symptoms get ill between 4 to 7 days after the bite. The infection is characterized by flu-like symptoms which include a sudden high fever coming in separate waves, pain behind the eyes, muscle, joint, and bone pain, severe headache, and a skin rash with red spots. Treatment includes supportive care of symptoms. There is no antiviral treatment available. The illness may progress to Dengue Hemorrhagic Fever (DHF). Symptoms include severe abdominal pain, vomiting, diarrhea, convulsions, bruising, and uncontrolled bleeding. High fever can last from 2 to 7 days. Complications can lead to circulatory system failure and shock, and can be fatal (also known as Dengue Shock Syndrome).. If you are infected with the same Dengue virus serotype you become immune to future infections. However, if you are infected subsequently with a different serotype, immunity wanes over time which increases the risk of developing ...

This page includes the following topics and synonyms: Dengue, Break-bone Fever, Dandy Fever, Duengero Fever, Seven-day Fever, Dengue Hemorrhagic Fever, Dengue Fever, Aden Fever, Dengue Shock Syndrome.

Dengue is a viral infection spread by mosquitoes. It is endemic in Malaysia, as it is in most tropical countries. Worldwide, dengue is also the fastest spreading mosquito-borne viral diseases. Symptoms can range from a mild fever to severe dengue fever with bleeding, accumulation of fluid in the lungs and abdomen, shock and death. Dengue doesnt choose who it affects, anybody can get dengue, whether young or old, woman or man. Health clinic staff and doctors would usually advise patients to drink more water if they are suspected to have dengue fever. Whether this is beneficial or not has not been well studied so far. If oral (by mouth) fluid intake is beneficial, the next question is how to improve the delivery of this advice to dengue patients who come to the primary health care clinics. A simple fluid chart has been designed that patients suspected of having dengue fever should complete every day for as long as they are being followed up by their doctor for the condition. The patient with ...

Infection with one virus does not protect a person against infection with another. A person can be infected by at least two, if not all four types of the dengue virus at different times during a life span, but only once by the same type. People contract dengue fever from the bite of an infected Aedes mosquito. Mosquitoes become infected when they bite infected humans, and later transmit infection to others.If not treated properly, dengue hemorrhagic fever may occur. Dengue hemorrhagic fever is severe and often fatal.Dengue fever can be caused by any one of four types of dengue virus:. ...

Objectives: The objective of this study was to identify clinical and neuroima-ing features and outcome of Patients with encephalitis and myelitis associated with dengue viral infection. Patients and methods: We retrospectively reviewed 225 cases of dengue viral infection. The diagnosis of dengue was confirmed by serology (presence of IgM antibodies). Results: Six Patients (3%) had evidence of neurological infection (encephalitis: 5 Patients, encephalomyelitis: I Patient). Age range was 18-35 years (Mean 27 years). Five Patients (83%) were women. All Patients (100%) had drowsiness, five Patients (83%) had fever, four Patients (67%) presented with seizures and one Patient presented with paraparesis (16%). All patients had elevated CSF cell count (range 25-102, mean 61) with predominant lymphocytes. Five Patients (83%) had abnormal CT or MRI scan. Cerebral edema was present in three Patients. Other findings included low density signals in right temporal and occipital lobe (1 Patient), bi temporal

TY - JOUR. T1 - Tri-phasic fever in dengue fever. AU - Pradeepa, H. D.. AU - Rao, Sathish B.. AU - Ganaraj, B.. AU - Bhat, Gopalakrishna. AU - Chakrapani, M.. PY - 2018/4/1. Y1 - 2018/4/1. N2 - Dengue fever is an acute febrile illness with a duration of 2-12 days. Our observational study observed the 24-h continuous tympanic temperature pattern of 15 patients with dengue fever and compared this with 26 others with fever due to a non-dengue aetiology. A tri-phasic fever pattern was seen among two-thirds of dengue fever patients, but in only one with an inflammatory disease. One-third of dengue fever patients exhibited a single peak temperature. Continuous temperature monitoring and temperature pattern analysis in clinical settings can aid in the early differentiation of dengue fever from non-dengue aetiology.. AB - Dengue fever is an acute febrile illness with a duration of 2-12 days. Our observational study observed the 24-h continuous tympanic temperature pattern of 15 patients with dengue ...

Ashish H. Bajaj, Yadav K.S. and Gomes Merlyn W.. ABSTRACT. Dengue fever, a mosquito-borne tropical disease and is also known as breakbone fever, caused by the dengue virus. Symptoms include fever, headache and joint pains and a characteristic skin rash that is similar to measles. In a minor proportion of cases, the disease develops into the life-threatening dengue hemorrhagic fever, resulting in bleeding, thrombocytopaenia and plasma leakage, or into dengue shock syndrome, where dangerously low blood pressure occurs. There are five strains of the virus, called serotypes, of which the first four are referred to as DENV-1, DENV-2, DENV-3 and DENV-4 (DENVDengue Virus). The fifth type (not named) was announced in 2013. The distinctions between the serotypes are based on their antigenicity. Dengue is one of the most rapidly spreading mosquito-borne viral diseases in the world. In the last 50 years, the incidence of dengue infection has increased almost 30-fold with increasing geographic expansion to ...

BACKGROUND Dengue infection is a major vector-borne disease. The classical sings and symptoms of this infection include high fever, violent headache, chill and rash. However, there are a number of atypical forms of dengue infection including those presented with liver dysfunction. However, there are only a few reports concerning the liver dysfunction among the patients with dengue infections. METHODS Here, the author presents a summative study on the liver dysfunction and its clinical correlation among Thai patients in the previous studies. A literature review on the prospective studies concerning liver function and dengue infection in Thailand was performed. RESULTS According to this study, there are 4 reports included covering 191 Thai pediatric patients with dengue infection. The overall rate of liver dysfunction among 191 subjects is 34.6 % (66/191). The rate of liver dysfunction among the patients without shock (36/120) is not significant different from those with shock. The rate of liver

The immune mechanisms involved in dengue fever and dengue hemorrhagic/dengue shock syndrome are not well understood. The ex vivo activation status of immune cells during the dengue disease in patients was examined. CD4 and CD8 T cells were reduced during the acute phase. Interestingly, CD8 T cells co-expressing activation marker HLA-DR, Q, P, and cytolytic granule protein-Tia-1 were significantly higher in dengue patients than in controls. Detection of adhesion molecules indicated that in dengue patients the majority of T cells (CD4 and CD8) express the activation/memory phenotype, characterized as CD44HIGH and lack the expression of the naïve cell marker, CD62LLOW. Also, the levels of T cells co-expressing ICAM-1 (CD54), VLA-4, and LFA-1 (CD11a) were significantly increased. CD8 T lymphocytes expressed predominantly low levels of anti-apoptotic molecule Bcl-2 in the acute phase, possibly leading to the exhibition of a phenotype of activated/effector cells. Circulating levels of IL-18, TGF-β1 ...

The Senate today approved on third and final reading a bill seeking to appropriate a P1.16 billion supplemental budget for the Department of Health (DOH) this year to fund medical assistance programs for dengue patients in the country.. House Bill No. 7449, sponsored by Senator Loren Legarda, chairperson of the Senate Committee on Finance and co-sponsored by Senator Richard Gordon, was approved with 18 affirmative votes, zero negative vote and no abstention.. According to Legarda, the supplemental budget of P1,161,710,000 for the DOH would be used exclusively to fund medical assistance programs for dengue patients, including those who are confined or are outpatients.. The above allocation will also be used to provide medical assistance for hospitalization, out-patient care services, procurement of supplies and medicine, she said.. The supplemental budget, Legarda said, would provide help and allay the fears of the almost 900,000 individuals, both children and adults, who were administered ...

Dengue fever is a painful, debilitating disease but is rarely fatal. Symptoms appear 3-14 days after the bite of an infected mosquito and include sudden onset of fever, severe headache, eye pain, muscle and joint pain (giving the disease the nickname breakbone fever), and bleeding. Gastrointestinal symptoms like vomiting and diarrhea may also be present in some cases. Dengue fever symptoms usually lasts 4-7 days. The disease is often diagnosed incorrectly because the symptoms are similar to influenza and other viruses. Dengue hemorrhagic fever is a rare but more severe form of dengue infection that can be fatal if not recognized and treated with supportive care. The primary risk factor for hemorrhagic fever is previous infection with a different dengue serotype (i.e. getting DENV-2 if you have already DENV-1 puts you at increased risk of hemorrhagic fever).SIMILAR STORIES: ...

Background Dengue pathogen (DENV) contamination may trigger serious hemorrhagic disease in human beings. when KU812 cells had been transfected with the autophagy-inhibiting Atg4BC74A mutant. Findings/Significance Our outcomes demonstrate a significant induction of autophagy in antibody-enhanced DENV contamination of pre-basophil-like KU812 and immature mast cell-like HMC-1 cells. Also, autophagy takes on an essential part in DENV contamination and duplication in these cells. Provided the importance of ADE and FcR-bearing cells such as monocytes, basophil/mast and macrophages cells in dengue disease, the outcomes offer information into dengue pathogenesis and restorative means of control. Intro Dengue disease is usually a serious wellness issue in exotic or subtropical areas of the globe [1], [2]. Dengue computer virus (DENV) contamination can trigger 1255517-77-1 supplier moderate dengue fever to serious life-threatening dengue hemorrhagic fever and dengue surprise symptoms [3]C[5]. Many systems ...

In the absence of an effective vaccine, vector control and surveillance of dengue fever (DF) and dengue hemorrhagic fever (DHF) are the most important strategies currently used to reduce the impact of these diseases in affected population. The objectives of this study were to estimate the incidence of symptomatic and asymptomatic dengue cases, the prevalence of antidengue antibodies, and to evaluate the laboratory and clinical aspects related to an active surveillance of dengue cases. In this study, active surveillance was incorporated as a part of the study design. At total of 3,255 people from four high risk neighborhoods were followed in a two years prospective study whereby the participants houses were visited three times a week. During these visits, dengue cases were characterized by identifying patients with fever as well as other symptoms that were compatible with dengue disease. In addition, a biannual blood sample was taken for each study participants, to establish the prevalence and six month

The first sign of dengue fever is a sudden, high grade fever and rash. The rash typically appears within two to five days, and may be followed by a second rash. General discomfort, headache, tiredness and skin sensitivity are common symptoms of dengue fever. Muscle pain and joint pain are usually present and may be severe enough to require medication. Nausea and vomiting frequently occur, and those with severe nausea or vomiting can easily become dehydrated. Excessive sweating is also a common symptom of the virus. Nosebleeds and bleeding gums are distinctive symptoms of dengue fever. People who bleed easily as a result of the infection may also bruise easily. A small number of people develop complications after becoming infected with dengue fever. Common complications include severe dehydration and febrile convulsions, which are seizures that are caused by a high fever. Febrile convulsions are most common in children under the age of five. Rarely, dengue hemorrhagic fever develops in some ...

Dengue viruses are members of the Flaviviridae, transmitted principally in a cycle involving humans and mosquito vectors. In the last 20 years the incidence of dengue fever epidemics has increased and hyperendemic transmission has been established over a geographically expanding area. A severe form, dengue hemorrhagic fever (DHF), is an immunopathologic disease occurring in persons who experience sequential dengue infections. The risk of sequential infections, and consequently the incidence of DHF, has risen dramatically, first in Asia and now in the Americas. At the root of the emergence of dengue as a major health problem are changes in human demography and behavior, leading to unchecked populations of and increased exposure to the principal domestic mosquito vector, Aedes aegypti. Virus-specified factors also influence the epidemiology of dengue. Speculations on future events in the epidemiology, evolution, and biological expression of dengue are presented.. ...

A reported 40 percent of the worlds population is at risk for dengue infection, with a rising number of home-grown cases occurring in the U.S. Dengue infection is caused by any of four related flaviviruses. Although some dengue infections are asymptomatic, severe infections of this flavivirus can cause hemorrhagic fever and dengue shock syndrome and have a higher risk of complications and death. Currently, no directed therapeutic options nor licensed vaccines.. In addition to UVM VTC investigators, the research team includes researchers from the Johns Hopkins Bloomberg School of Public Health, the National Institute of Allergy and Infectious Disease (NIAID), the La Jolla Institute for Allergy and Immunology, the University of North Carolina, and Atreca, Inc. A major focus of this study is the antibodies and T-cell responses produced in the blood in response to the dengue. The team is examining how the immune system recognizes dengue virus in an effort to confirm the protective effects of new ...

BACKGROUND: Dengue is one of the most important human diseases transmitted by an arthropod vector and the incidence of dengue virus infection has been increasing - over half the worlds population now live in areas at risk of infection. Most infections are asymptomatic, but a subset of patients experience a potentially fatal shock syndrome characterised by plasma leakage. Severe forms of dengue are epidemiologically associated with repeated infection by more than one of the four dengue virus serotypes. Generally attributed to the phenomenon of antibody-dependent enhancement, recent observations indicate that T-cells may also influence disease phenotype. METHODS AND FINDINGS: Virus-specific cytotoxic T lymphocytes (CTL) showing high level cross reactivity between dengue serotypes could be expanded from blood samples taken during the acute phase of secondary dengue infection. These could not be detected in convalescence when only CTL populations demonstrating significant serotype specificity were

There are 4 distinct, but closely related, serotypes of the virus that cause dengue (DEN-1, DEN-2, DEN-3 and DEN-4). Recovery from infection by one provides lifelong immunity against that particular serotype. However, a cross-immunity to the other serotypes after recovery is only partial and temporary. Subsequent infections by other serotypes increase the risk of developing a severe dengue. The incidence of dengue has grown dramatically around the world in recent decades.. The recent estimate indicates 400 million dengue infections per year. Dengue fever is a severe, flu-like illness that affects infants, young children and adults, but seldom causes death.. I was infected in Thailand. Ive been there for a few months, using repellents (I guess that not enough), and everything was ok until one day. The mosquitos bit me, but I didnt think about it much. It was hard to imagine that something can get wrong when everything around is so beautiful and the sun is shinning, right? I remember that one ...