Two new 24-homoscalarane sesterterpenoids, felixins F (1) and G (2), were isolated from the sponge Ircinia felix. The structures of new homoscalaranes 1 and 2 were elucidated by extensive spectroscopic methods, particularly with one-dimensional (1D) and two-dimensional (2D) NMR, and, by comparison, the spectral data with those of known analogues. The cytotoxicity of 1 and 2 against the proliferation of a limited panel of tumor cell lines was evaluated and 1 was found to show cytotoxicity toward the leukemia K562, MOLT-4, and SUP-T1 cells (IC50 ≤ 5.0 μM).

Meroterpenoids are a class of fungal natural products that are produced from polyketide and terpenoid precursors. An understanding of meroterpenoid biosynthesis at the genetic level should facilitate engineering of second-generation molecules and increasing production of first-generation compounds. …

Chen, Q.; Jiang, T.; Liu, Y.-X.; Liu, H.; Zhao, T.; Liu, Z.; Gan, X.; Hallab, A.; Wang, X.; He, J. et al.; Ma, Y.; Zhang, F.; Jin, T.; Schranz, M. E.; Wang, Y.; Bai, Y.; Wang, G.: Recently duplicated sesterterpene (C25) gene clusters in Arabidopsis thaliana modulate root microbiota. SCIENCE CHINA-LIFE SCIENCES 62 (7), S. 947 - 958 (2019 ...

Stimulating encounter: The intimate, physical interaction between the soil-derived bacterium Streptomyces rapamycinicus and the human pathogenic fungus Aspergillus fumigatus led to the activation of an otherwise silent polyketide synthase (PKS) gene cluster coding for an unusual prenylated polyphenol (fumicycline A). The meroterpenoid pathway is regulated by a pathway-specific activator gene as well as by epigenetic factors.. ...

Figure 9. Substrate-docking simulation of RdPT1. A to C, Putative substrate-binding cavities docked with FPP (A), GPP (B), and GGPP (C) in the presence of OSA and magnesium ions, which are shown in the closeup views. In each part, OSA is shown in yellow and prenyl diphosphate in light orange as a stick model. Magnesium ions are presented as dark gray spheres. Only selected amino acid residues that are predicted to participate in substrate binding are shown as white stick models, with nitrogen atoms colored blue and oxygen atoms colored red. Hydrogen bonds are shown as green dotted lines. The distance between OSA C-3 and prenyl diphosphate C-1 is indicated with a red dotted line, while that between each terminal carbon of prenyl diphosphate and Ala-149 is shown with a blue dotted line. D, Protein surface representation of the active site cavity docked with GGPP and OSA as in C. ...

A screening program designed to find new antiinflammatory agents has identified the sponge meroterpenoid pelorol (1) as an in vitro activator of the inositol-5-phosphatase SHIP. Pelorol (1) and several functional group analogues have been synthesized from sclareolide (4).. ...

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was found in FFP, PS or Carprofen treated animals (p,0.05). In a sTNFR1 blocking experiment, incubation of HFP with anti-sTNFR1 antibody resulted in significant increases in neutrophil numbers and TNFα levels, which suggests that the anti-TNFα activity observed in HFP may be due to elevated levels of sTNFR1. The data also revealed a significant inverse correlation between total leukocyte counts and sTNFR1 levels present in pouch fluid (r=−0.73, p,0.0001). Our observations suggest that HFP warrants further investigation as a possible means for modulating acute inflammatory processes where TNFα is a key mediator.. ...

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dr. LeFever, you might have simply posted to ask me if i were being sarcastic in posting back your statment rather than repeating it yourself (below) although using different words. please see the top of that repost of your original and edited message, where i wrote the following: point well-taken (both times). i am not sure i have ever heard this phrase used in a sarcastic light. i am sorry that i had to snip all of your examples of my ignorance below (my server will not let me respond to a post where the response has less text than the post it is a response to). and this is much less text. colleen specht ...

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Domain: Eukaryota • Regnum: Chromista • Phylum: Ochrophyta • Classis: Phaeophyceae • Ordo: Fucales • Familia: Fucaceae • Genus: Pelvetia • Species: Pelvetia canaliculata (L.) Dcne. et Thur. ...

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Experiments on Pelvetia canaliculata re-colonization on the Isle of Man found growth rates varied between 1.8 - 4.8 cm /annum, with an average of 3.18 cm /annum (Subrahmanyan, 1960). Growth rates between 3-5 cm / annum have also been recorded by Schonbeck & Norton (1980) and Rugg & Norton (1987). Growth rates in Pelvetia canaliculata were found to differ depending on shore height and level of shore exposure (Subrahmanyan, 1960). Those individuals found higher in the Pelvetia zone were smaller than those found lower down. The reason for dwarfism in Pelvetia canaliculata higher up in the shore zone is thought to be directly connected to the levels of desiccation (Subrahmanyan, 1960). Subrahmanyan (1960) found that Pelvetia canaliculata grew faster on more wave sheltered shores. Pelvetia canaliculata abundances also correlate with summer temperatures (Yesson et al., 2015). Within Pelvetia canaliculata populations on the Isle of Man vegetative growth and reproductive activity cycle once per annum ...

Date: Wed, 10 Sep 1997 16:49:41 +0100 (BST) From: Dave Carter ,[email protected], To: marduk ,[email protected], cc: WWW-HTML Mailing List ,[email protected], In-Reply-To: ,[email protected], Message-ID: ,Pine.SOL.3.96.970910164556.5084F-100000@cass40, Subject: Re: HTML4.0 draft: comments re: inclusion of frames (fwd) On Wed, 10 Sep 1997, marduk wrote: , , MZ writes: , , I completely disagree. Personally I think the 3.0 proposal was bloated , , with more worthless crap that 3.2 or 4.0. , , I just joined this list, so I dont knwo whther this has been discussed , before, but I see the 4.0 proposal as doing exactly what I felt the 3.2 , proposal did, mainly to keep up with what has already been implemented by , Netscape and Microsoft and generally already accepted as standard. The only thing I would disagree with here is the notion that implementing what Netscape and Microsoft want is in any sense keeping up. Keeping up implies with something worthwhile. , , It ...

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Autotaxin is the enzyme responsible for the production of lysophosphatidic acid (LPA) from lysophosphatidyl choline (LPC) and is upregulated in many inflammatory conditions, including but not limited to cancer, arthritis and multiple sclerosis. LPA signaling causes angiogenesis, mitosis, cell proliferation and cytokine secretion. Inhibition of autotaxin may have anti-inflammatory properties in a variety of diseases, however, this hypothesis has not been tested pharmacologically due to the lack of potent inhibitors. Here we report the development of a potent autotaxin inhibitor (PF-8380) with an IC50 of 2.8 nM in isolated enzyme assay and 101 nM inhuman whole blood. PF-8380 has adequate oral bioavailability and exposures required for in vivo testing of autotaxin inhibition. Autotaxins role to produce LPA in plasma and at the site of inflammation was tested in a rat air pouch model. The specific inhibitor PF-8380, dosed orally at 30 mg/kg, provided , 95% reduction in both plasma and air pouch LPA ...

Biochemical disorders induced by cytotoxic marine natural products in breast cancer cells as revealed by proton NMR spectroscopy-based metabolomics. - Mathilde Bayet-Robert, Suzanne Lim, Chantal Barthomeuf, Daniel Morvan

Forwarded message ---------- Date: Tue, 14 Jun 1994 19:58:00 +0800 (WST) From: Philip OBrien ,obrien at csuvax1, To: methodsandreagents at net.bio.net Subject: Returned mail: User unknown (fwd) ---------- Forwarded message ---------- Date: Tue, 14 Jun 94 19:54:55 +0800 From: Mail Delivery Subsystem ,MAILER-DAEMON at csuvax1, To: postmaster at csuvax1, obrien at csuvax1 Subject: Returned mail: User unknown ----- Transcript of session follows ----- 550 methods-and at csuvax1... User unknown ----- Unsent message follows ----- Received: by csuvax1.murdoch.edu.au (5.65/1.34) id AA24084; Tue, 14 Jun 94 19:54:55 +0800 Date: Tue, 14 Jun 1994 19:45:50 +0800 (WST) From: Philip OBrien ,obrien at csuvax1, Subject: DEGENERATE PCR To: methods-and at csuvax1 Message-Id: ,Pine.3.87.9406141950.A23910-0100000 at csuvax1, Mime-Version: 1.0 Content-Type: TEXT/PLAIN; charset=US-ASCII Dear netters In order to clone pectic enzyme genes from fungi we have identified conserved regions within the genes (from amino acid ...

I agree that the semantic grid could be a good use case for our semantic enabled registry. If this is the case, we might need to look into how the semantics of things that grid computing is looking at such as dynamic provisioning. It seems like a lot to bite off, maybe the best path is to read enough to know that we can add the dynamics of OGSI later. -----Original Message----- From: Farrukh Najmi [mailto:[email protected]] Sent: Wednesday, January 07, 2004 3:48 PM To: [email protected] Subject: Re: [regrep] [Fwd: SemPGRID04: Call for Paper (DATE CORRECTIONS!)] Carl Mattocks wrote: ,I propose that the regrep-scm folk create a position paper stating that ,Federated Registries enable the semantic backbone of a grid , , I know very littleabout grid computing right now but my gut instinct is that ebXML Registry can play an important role as an enabling technology even today. This assumes that grid computing needs distributed content much like normal comuting needs a database. That ...

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Sou da opinião de que, neste tipo de meio, tirando certas regras bem básicas como ser colaborador do GNOME e não postar pornografia ou material violento ou discriminatório, o filtro deve caber ao leitor e não a um revisor. Se um assunto ou post não interessa simplesmente pule para o próximo, simples assim ...

John Erickson wrote: , +1 to Danbris emphasis on LINKs, because at the end of the day , linking is what its all about! , Of course, its about LINKs. EAV enables you to use LINKs to traverse the structured description of anything. Kingsley , John , , 2010/4/18 Ji Proch zka ,[email protected],: , ,, Why URL when it is pretty clearly defined and still significant portion of web users dont understand it. ,, ,, Id rather embrace web address - even non-tech users would understand ,, that. ,, ,, Best, ,, Jiri Prochazka ,, ,, On 04/18/2010 12:18 PM, Dan Brickley wrote: ,, ,,, So - Im serious. The term URI has never really worked as something ,,, most Web users encounter and understand. ,,, ,,, For RDF, SemWeb and linked data efforts, this is a problem as our data ,,, model is built around URIs. ,,, ,,, If URL can be brought back from limbo as a credible technical term, ,,, and rebranded around the concept of linkage, I think itll go a long ,,, way towards explaining what were up to with ...

Title:Thiazole: A Privileged Motif in Marine Natural Products. VOLUME: 16 ISSUE: 1. Author(s):Sunil Kumar* and Ranjana Aggarwal. Affiliation:Department of Chemistry, Kurukshetra University, Kurukshetra-136119, Department of Chemistry, Kurukshetra University, Kurukshetra-136119. Keywords:Marine natural products, thiazoles, alkaloids, cytotoxic activity, privileged, secondary metabolite.. Abstract:Marine natural products have proven to be a rich source of drugs and drug leads. These natural products are secondary metabolites and show biological activity against bacteria, fungi and viruses. Natural products containing thiazole ring occur often in marine sources. They exhibit diverse and remarkable biological activities, including antitumor, antibacterial, anti-inflammatory and cytotoxic activities, to name a few. This review surveys the natural thiazole derivatives that have been isolated from marine microorganisms, with emphasis on biological implications in last three decades.. ...

The aim of this study was to investigate possible regulation of the hyperpolarization-activated current (I(f)) by cytosolic calcium in guinea-pig sino-atrial (SA) node cells. Isolated SA node cells were superfused with physiological saline solution (36 degrees C) and the perforated patch voltage-clamp technique used to record I(f) activated by hyperpolarizing voltage steps. A 10-min loading of SA node cells with the calcium chelator BAPTA (using 10 microM BAPTA-AM) significantly reduced the amplitude of I(f) at all potentials studied (69+/-8% at -80 mV, n=6). BAPTA loading also shifted the voltage of half-activation (V(h)) of the conductance from -83+/-2 mV in control to -93+/-2 mV in BAPTA (n=6) without significantly altering the slope of activation. The calmodulin antagonists W-7 (10 microM), calmidazolium (25 microM) and ophiobolin A (20 microM) caused similar reductions in I(f) amplitude (73+/-4, 86+/-9 and 59+/-6% at -80 mV, n=6, 5 and 4, respectively) and shifts in V(h) (11+/-3, 14+/-3 and 8+/-2

Natural products have been a rich source of compounds with structural and chemical diversity for drug discovery. However, antibiotic resistance in bacteria has been reported for nearly every antibiotic once it is used in clinical practice. In the past decade, pharmaceutical companies have reduced their natural product discovery projects because of challenges, such as high costs, low return rates, and high rediscovery rates. The largely unexplored marine environment harbours substantial diversity and is a large resource to discover novel compounds with novel modes of action, which is essential for the treatment of drug-resistant bacterial infections. In this Review, we report compounds derived from marine sources that have shown in-vivo and in-vitro efficacy against drug-resistant bacteria. Analysis of the physicochemical properties of these marine natural products with activity against drug-resistant bacteria showed that 60% of the compounds have oral bioavailability potential. Their overall ...

UCL Discovery is UCLs open access repository, showcasing and providing access to UCL research outputs from all UCL disciplines.

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14 You do the math... Cre-mediated inversion yields 40% reverse orientation per trans-floxed allele Homozygosity for trans-floxed alleles should yield 40% loss of total copies of functional gene across tissue -20% of cells will remain unaffected and fwd/fwd -20% of cells will end up fwd/fwd after inversion -40% of cells will end up fwd/rev after inversion -20% of cells will end up rev/rev after inversion ...

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The first contemporary handbook to solely feature the broad field of marine product chemistry Handles all dimensions of the field and therefore suitable

Dont do it, Frank. Get your books from www.bookpool.com. OReilly books are routinely 35% off at Bookpool, and they feature a different publisher every few months for 44% off. Janine , -----Original Message----- , From: owner-lexington-pm-list at pm.org , [mailto:owner-lexington-pm-list at pm.org]On Behalf Of Frank Price , Sent: Wednesday, August 16, 2000 4:34 PM , To: lexington-pm-list at happyfunball.pm.org , Subject: Re: LPM: [Fwd: OReilly Needs Guinea Pigs...Any Volunteers?] , , , On Wed, Aug 16, 2000 at 04:29:33PM -0400, Rich Bowen wrote: , , FYI , , , , As a thank you for your time and insight, well give you a 25% discount , , on all OReilly books purchased through the OReilly Web site for one , , year (5% more than the regular UG discount), plus enter you in a drawing , , for one of 200 Official OReilly Guinea Pig T-shirts. , , So Im not really interested in taking this survey, but the 20% off , for UGs caught my eye. Do we, as individual members, get this, and if , so how do you ...

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In the early 80s, GM had grand plans to continue the downsizing process until it swtiched all cars to FWD. The plan was that all b-cars were to swtich to FWD around 1985-86, but in the end only the Olds and Buick did in 1986 followed by Pontiac in 1987. These cars became the GM H-body instead of replacing the B-body like they were intended. GM planned to have an intermediate step between the 1977 B-body and the 1986 H-car and that was to downsize the B-bodies to the G-body line. Originally, Chevrolet had planned for 1983 (approx) to have the Caprice Impala to be a rebadged Malibu. Of course, sales of big cars picked up and this plan never came to light as the B-body continued until 1996.. That said, Pontaic did carry out its plan to downsize the Bonneville to the smaller G-body which is why we had the small Bonneville for 1982. GM of Canada was not happy about this move, as for many years fullsize Pontiacs were big sellers in Canada, having unique Canadian models and being more of a entry level ...

with default-jdk and have default-jre as the first alternative. If it _does_ only work with openjdk then you should not depend on , java2-runtime. In any case you dont need to depend on , sun-java5-jre , sun-java6-jre given that they provide java2-runtime ...

On Tue, Aug 30, 2011 at 16:30, Michael Foord ,mfoord at python.org, wrote: , On 30/08/2011 14:35, Patrick Ben Koetter wrote: , ,, I live next to Gert. Should I go over and shake his hands… ;) ,, ,, But seriously, this seems to be a problem introduced by XS4all. Is there ,, anything we can/should do about? ,, , , I have no idea :-) , , The email came in to webmaster at python.org so I thought it should be sent , to this list, so that someone who understood it could decide whether or not , it needed our input. , noc at xs4all.nl at least (and peering at xs4all.nl probably as well) ends up with the right people, some of whom are very active in the IPv6 community, so Im sure theyll resolve it one way or another posthaste. , ,, p at rick ,, ,, ,, ,, ,, * Michael Foord,michael at voidspace.org.uk**,: ,, ,,, Begin forwarded message: ,,, ,,,, From: Mark Mahle,mm at VR.ORG, ,,,, Subject: XS4ALL strict IPv6 filtering ,,,, Date: 30 August 2011 13:19:54 GMT+01:00 ,,,, To: noc at xs4all.nl ,,,, Cc: ...

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Well, cant have 300hp at front wheels and 50hp and back with FWD based platform. It could be an e-axle? Where engine powers battery that then powers RWD...

With fall officially upon those in the northern hemisphere, cold weather camping season has arrived as well. Few images propel us into the outdoors quite like that of a warm campfire with friends. While classic flint and tinder fire-starters are a great resource, in wet conditions nothing beats the reliability and consistency of a basic Bic lighter. To keep this essential piece of survival equipment safe, outdoor brand Exotac recently introduced the FireSLEEVE, a reusable, waterproof rubber sleeve capable of extending the life of a lighter to ensure you have fire when you need it most.. ...